Hub : Genes

MACROD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Prostate Adenocarcinoma 0.0294 0.016 0.0052 0.038 0.018 0.027 NA 0.029 6.8e-05 0.0053 0.00067 NA 0.00046
2 TCGA Uterine Corpus Endometrial Carcinoma 0.2170 0.107 0.0053 0.027 0.056 0.049 NA 0.084 6.0e-02 0.0120 0.01700 NA 0.00240

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.7 2.7 4.8 0.8 -2.2
Bipolar Disorder or Schizophrenia 1.7 4.2 7.0 1.1 -2.6
Depressed Affect (Nagel 2018) 1.4 2.9 5.8 -0.2 2.4
Depression (Nagel 2018) 0.1 0.2 0.3 0.6 -0.1
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.4 -0.6 -1.2
Neuroticism (Nagel 2018) 0.8 1.8 3.5 -0.0 1.9
Schizophrenia (2018) 0.9 1.8 2.9 0.8 -1.7
Schizophrenia vs Biploar Disorder 0.5 0.7 0.7 -0.8 -0.8
Worry (Nagel 2018) 1.2 2.6 3.4 1.8 1.4
Alzheimer’s Disease (in mother) 0.6 0.7 1.4 1.2 -0.0
Alzheimer’s Disease (in father) 0.6 0.7 1.2 -0.4 1.1
Alzheimer’s Disease (including proxy) 1.0 1.5 2.8 1.7 -0.4
Crohns Disease (2017) 2.8 6.2 7.6 -2.2 -2.8
Irritable Bowel Disease (IBD) 1.2 2.8 3.3 -1.5 -1.8
Ulcerative Colitis (UC) 0.1 0.2 0.3 -0.5 -0.3
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0
Reaction Time 7.3 13.9 27.4 5.2 -0.6
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.1 -0.2 -1.1
Breast Cancer 1.4 3.3 4.2 -2.1 -1.5
Ovarian Cancer 0.7 0.9 1.4 -1.2 -0.7
Prostate Cancer 1.7 2.4 2.8 1.7 1.5
Age at First Birth 0.1 0.2 0.3 0.6 -0.1
Bipolar Disorder (2011) 1.0 1.0 1.9 1.4 0.2
Body Mass Index (BMI) (2010) 0.8 1.1 2.0 -1.4 0.5
Coronary Artery Disease (CAD) 0.2 0.3 0.4 0.4 -0.7
Crohns Disease (2012) 1.6 2.6 4.0 -2.0 -1.1
Mean Putamen Volume 0.3 0.4 0.7 0.8 0.1
Fasting Glucose 0.1 0.1 0.2 0.4 -0.0
HbA1C 0.1 0.2 0.3 0.1 -0.5
HDL Cholesterol 0.4 0.7 1.3 -1.2 0.1
LDL Cholesterol 0.7 1.1 1.4 -1.2 -0.8
Lupus 0.3 0.5 0.5 -0.7 -0.7
Neuroticism (2016) 0.4 0.5 0.7 -0.8 -0.6
Primary Biliary Cirrhosis 0.9 1.3 2.4 -1.5 0.4
Rheumatoid Arthritis 0.2 0.3 0.5 0.4 0.7
Schizophrenia (2014) 1.0 2.3 3.5 1.0 -1.9
Triglycerides 0.4 0.7 1.3 -0.2 1.1
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.6 0.8 0.2
Ulcerative Colitis 0.2 0.3 0.3 -0.6 -0.5
Blood Eosinophil Count 0.6 4.6 8.6 2.9 0.8
Blood Platelet Count 5.2 60.3 104.0 -10.2 -4.1
Blood Red Count 0.0 0.1 0.1 -0.4 -0.2
Blood White Count 0.1 0.7 1.4 0.0 -1.2
Heel T-Score 1.2 9.3 12.8 -2.4 -3.6
BMI 1.6 9.3 15.1 -3.9 1.9
Height 0.2 3.6 4.9 -1.5 2.2
Waist Hip Ratio (WHR) 0.3 1.2 2.2 1.5 0.4
Systolic Blood Pressure 3.0 15.0 17.2 3.6 4.2
Smoking Status 1.4 3.4 4.0 -1.6 2.0
Allergy or Eczema 0.6 1.6 3.3 -1.8 -0.0
Cardiovascular Disease 0.6 2.0 3.6 -0.6 1.9
Hypothyroidism (self reported) 0.2 0.5 0.5 0.7 0.7
Respiratory disease 0.2 0.4 0.8 -0.9 0.2
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.2 -0.1 -0.5
Lung FEV1/FVC ratio 1.3 6.4 7.9 -2.8 -2.2
Lung FVC 0.9 4.7 8.5 -0.9 -2.9
Neuroticism 1.7 4.1 6.5 1.3 2.6
Chronotype (morning person) 1.7 3.8 6.9 2.6 -0.9
Hair Pigment 0.1 2.4 3.2 -1.3 1.8
Tanning 0.1 1.1 1.7 0.8 -1.3
Hand grip strength (left) 1.5 4.0 5.3 -2.3 -1.6
Number of treatments/medications taken 0.4 0.6 1.3 -0.1 1.1
Average weekly spirits intake 0.6 0.7 0.9 0.9 -0.7
Sensitivity / hurt feelings 0.4 0.7 0.9 0.7 -1.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.5 -0.1 -0.7
Hearing difficulty/problems: Yes 1.8 2.8 5.5 -0.4 2.3
Relative age of first facial hair 3.3 6.7 9.7 -3.1 -1.9
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 1.9 -0.1 -1.4
Ever used hormone-replacement therapy (HRT) 3.8 4.8 9.3 -3.1 -0.5
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.4 -0.6
Systolic blood pressure, automated reading 0.9 2.6 5.2 -0.1 2.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 0.9 0.7 -0.9
Angina 0.8 1.0 1.9 -1.4 0.2
Medication for hormone replacement therapy 0.8 0.8 1.4 -1.2 -0.6
Vitamin and mineral supplements 0.2 0.2 0.3 -0.6 -0.3
Supplements: Zinc 2.5 2.7 5.4 2.3 0.1
Medication: Co-codamol 3.1 3.6 7.1 -2.7 -0.2
Medication: Metformin 0.6 0.8 1.2 -1.1 -0.7
Diabetes (father) 0.5 0.7 0.8 -0.8 0.9
Diabetes (mother) 1.4 1.8 2.6 -1.0 -1.6
Severe depression (siblings) 0.1 0.1 0.2 -0.4 -0.1
Pack years adult smoking proportion 0.2 0.3 0.3 0.6 0.4
Impedance of leg (right) 0.1 0.7 1.4 1.2 0.1
Leg fat-free mass (left) 1.1 5.8 7.9 -2.8 1.9
Trunk fat percentage 2.8 11.3 21.4 -4.6 1.1
Hand grip strength (right) 1.0 2.8 3.8 -1.3 -2.0
Townsend deprivation index at recruitment 0.9 1.3 2.5 -0.4 1.6
Current tobacco smoking 0.6 1.0 1.5 -1.2 0.6
Average weekly fortified wine intake 0.6 0.7 1.4 1.2 -0.2
Maternal smoking around birth 1.4 2.0 3.1 -0.9 1.8
Fed-up feelings 4.4 8.0 16.0 -0.2 4.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 2.8 -0.3 1.7
Relative age voice broke 2.5 3.8 6.2 -2.5 -1.2
Taking other prescription medications 0.1 0.2 0.3 0.3 0.5
Age when periods started (menarche) 2.6 6.3 9.3 -3.0 -1.8
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.7 0.4 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 2.1 0.6 -1.4
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.5 0.6 0.7
Qualifications: CSEs or equivalent 0.4 0.6 1.1 -1.1 -0.1
Serious illness, injury or assault to yourself 0.3 0.4 0.8 0.1 0.9
High blood pressure 1.2 3.3 6.5 -0.4 2.5
Hayfever, allergic rhinitis or eczema 0.6 1.2 2.2 -1.5 0.4
Multivitamins +/- minerals 0.1 0.1 0.1 0.4 -0.3
Stomach or abdominal pain in last month 1.0 1.2 1.4 -1.2 -1.0
Supplements: Glucosamine 0.2 0.3 0.6 0.1 -0.8
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 0.2 -0.1
Medication: Atenolol 0.2 0.2 0.5 0.0 0.7
Medication: Levothyroxine sodium 1.1 1.9 3.6 0.5 1.9
Sitting height 0.3 1.8 3.6 -0.2 1.9
Chronic bronchitis/emphysema (father) 1.6 1.9 2.8 -1.0 -1.7
High blood pressure (mother) 1.0 1.3 2.6 -0.2 1.6
Body mass index (BMI) 2.2 9.3 18.1 -4.3 0.6
Impedance of leg (left) 0.3 1.2 2.4 1.6 -0.2
Leg predicted mass (left) 1.1 6.0 8.1 -2.9 1.9
Trunk fat mass 2.6 11.1 19.7 -4.4 1.6
Waist circumference 1.3 4.7 8.5 -2.9 0.9
Number of incorrect matches in round 2.4 3.9 7.3 2.7 -0.7
Past tobacco smoking 0.9 1.6 1.9 1.1 -1.4
Alcohol usually taken with meals 2.1 3.5 5.3 -1.3 -2.3
Nervous feelings 0.7 1.4 2.6 0.4 1.6
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.8 3.2 -1.8 -0.6
Hearing difficulty/problems with background noise 0.4 0.7 1.0 -1.0 -0.6
Hair/balding pattern: Pattern 2 1.3 1.6 2.1 -1.1 -1.4
Had menopause 7.1 8.8 8.9 -3.0 -3.0
Had other major operations 0.1 0.2 0.3 -0.0 0.6
Forced vital capacity (FVC) 0.3 1.2 2.1 0.6 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.6 3.1 0.3 -1.8
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.6 -0.4 -0.8
Qualifications: None of the above 0.8 1.8 2.5 -1.1 1.6
Financial difficulties in last 2 years 0.3 0.4 0.6 -0.4 0.8
Mouth/teeth dental problems 2.7 4.1 8.1 2.9 -0.4
Heart attack 0.4 0.5 0.8 0.9 -0.3
Allergy 0.9 2.0 3.8 2.0 -0.4
Pain all over the body in last month 0.3 0.4 0.7 -0.0 0.8
Diabetes (self-reported) 0.3 0.4 0.6 -0.8 -0.5
Hayfever/allergic rhinitis (self-reported) 0.3 0.3 0.6 -0.7 -0.4
Medication: Ramipril 0.7 0.9 1.0 -1.0 1.0
Medication: Simvastatin 1.5 2.2 4.2 -2.1 -0.5
Fluid intelligence score 0.3 0.7 0.9 0.7 -1.0
Illnesses of siblings 0.1 0.2 0.2 0.4 0.4
Neuroticism score 0.7 1.5 2.5 0.8 1.6
Weight 1.9 9.3 16.8 -4.1 1.3
Impedance of arm (right) 0.0 0.2 0.2 -0.4 -0.4
Arm fat percentage (right) 2.8 11.0 21.1 -4.6 0.9
Trunk fat-free mass 0.5 2.9 4.6 -1.1 2.1
Hip circumference 1.5 6.5 12.2 -3.5 0.9
Time employed in main current job 2.1 2.4 3.3 1.2 1.8
Alcohol intake versus 10 years previously 0.5 0.8 1.5 1.2 0.3
Father’s age at death 0.3 0.4 0.9 0.1 -0.9
Worrier / anxious feelings 0.5 0.9 1.3 1.1 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.2 -1.1 0.3
Falls in the last year 0.2 0.3 0.5 -0.7 -0.0
Hair/balding pattern: Pattern 3 1.8 2.7 3.4 1.8 1.4
Number of live births 8.6 12.2 22.2 -4.7 -1.5
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 3.5 -0.6 -1.9
Pulse rate 1.7 2.9 5.6 -2.4 -0.4
Happiness 0.2 0.3 0.5 -0.3 0.7
Noisy workplace 0.5 0.6 0.8 -0.9 0.6
Qualifications: A levels/AS levels or equivalent 1.0 2.2 2.9 1.7 -1.3
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 1.7 1.2 1.3
Mouth/teeth dental problems: Dentures 1.7 2.9 5.6 -2.4 0.4
Asthma 1.2 2.4 4.6 -2.1 -0.5
Medication: Ibuprofen (e.g. Nurofen) 2.6 3.3 4.8 1.4 2.2
Medication: Cholesterol lowering 0.3 0.5 0.8 -0.4 -0.9
Depression (self-reported) 1.4 1.7 1.8 -1.3 -1.3
Medication: Lansoprazole 1.1 1.3 2.1 -1.5 -0.7
Prospective memory result 0.1 0.1 0.3 -0.1 -0.5
Lung cancer (father) 0.2 0.3 0.5 0.2 0.7
Illnesses of mother 0.1 0.1 0.1 0.2 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.4 3.4 -1.1 -1.9
Pulse wave Arterial Stiffness index 0.5 0.6 0.6 -0.8 0.8
Impedance of arm (left) 0.0 0.1 0.1 0.1 -0.3
Arm fat mass (right) 2.8 11.7 22.2 -4.7 1.1
Trunk predicted mass 0.5 2.9 4.5 -1.1 2.1
Standing height 0.2 1.5 3.1 -0.0 1.8
Length of working week for main job 0.2 0.2 0.4 -0.2 -0.6
Exposure to tobacco smoke at home 1.8 2.0 2.0 -1.4 1.4
Breastfed as a baby 1.2 1.5 3.1 -0.0 -1.8
Tense / ‘highly strung’ 0.3 0.5 0.8 0.9 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 4.5 -1.4 -2.1
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 0.8 0.4
Birth weight of first child 2.9 5.3 8.1 -1.6 -2.8
Peak expiratory flow (PEF) 1.4 3.3 4.6 -2.1 -1.4
Pulse wave reflection index 2.1 2.6 4.2 1.0 2.0
Ever highly irritable/argumentative for 2 days 0.2 0.3 0.3 -0.5 0.5
Loud music exposure frequency 0.2 0.3 0.5 -0.7 0.1
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 4.2 -0.2 -2.1
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 2.0 -1.4 -0.3
Blood clot in the leg (DVT) 1.1 1.4 2.8 0.3 1.7
Medication: Paracetamol 0.0 0.1 0.1 -0.2 0.2
Headache pain in last month 0.4 0.7 1.1 -0.5 1.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.4 0.1 -0.7
Glaucoma (self-reported) 1.3 1.5 1.9 -1.0 1.4
Gout (self-reported) 0.4 0.6 0.9 -0.5 -0.9
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.1 -0.3 1.0
Medication: Amlodipine 1.3 1.8 3.5 0.4 1.9
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.2 -0.5 -0.3
Birth weight 4.3 9.3 11.2 -2.7 -3.3
Chronic bronchitis/emphysema (mother) 1.7 2.0 2.3 -1.3 -1.5
High blood pressure (siblings) 1.1 1.6 2.3 1.0 1.5
Forced vital capacity (FVC), Best measure 0.2 0.8 1.6 -0.1 -1.3
Body fat percentage 2.8 11.0 20.8 -4.6 1.1
Leg fat percentage (right) 2.1 7.7 14.1 -3.8 1.2
Arm fat-free mass (right) 0.6 3.1 3.1 -1.8 1.8
Exposure to tobacco smoke outside home 1.0 1.4 1.7 -1.3 1.0
Comparative body size at age 10 0.0 0.1 0.2 -0.5 0.2
Number of full brothers 6.1 7.7 7.8 -2.8 -2.8
Worry too long after embarrassment 0.5 0.8 1.2 -1.1 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 2.7 1.6 -1.6
Wheeze or whistling in the chest in last year 0.3 0.5 0.9 -0.4 0.9
Number of children fathered 1.6 1.9 3.6 -0.3 -1.9
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 2.7 -1.6 -1.2
Age at first live birth 1.7 3.0 5.9 2.4 -0.3
Pulse wave peak to peak time 0.4 0.5 0.6 0.8 -0.6
Health satisfaction 0.5 0.7 1.3 -1.1 0.3
Shortness of breath walking on level ground 1.7 2.1 3.1 -1.8 -1.0
Qualifications: College or University degree 1.7 5.3 10.4 -0.5 -3.2
Eye problems/disorders: None of the above 0.0 0.0 0.0 0.0 -0.0
Mouth/teeth dental problems: Loose teeth 3.4 4.0 7.9 -0.3 2.8
Emphysema/chronic bronchitis 0.9 1.0 1.5 1.2 0.7
Medication for pain relief, constipation, heartburn 0.4 0.7 1.4 -1.2 -0.2
Neck or shoulder pain in last month 1.0 1.5 2.6 -1.6 0.6
Medication: Blood pressure 0.6 1.1 1.7 0.8 1.3
Angina (self-reported) 0.5 0.6 1.2 -1.1 0.3
Migraine (self-reported) 2.0 2.5 3.7 1.9 -1.1
Medication: Ibuprofen 1.5 1.8 2.0 1.4 1.3
Medication: Allopurinol 0.0 0.1 0.1 -0.3 0.2
Medication: Omeprazole 0.1 0.1 0.2 0.0 -0.5
Medication: Seretide 50 evohaler 1.1 1.3 2.2 -1.5 -0.6
Mean time to correctly identify matches 6.4 12.3 24.3 4.9 -0.5
Heart disease (mother) 1.2 1.4 1.7 -1.3 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.3 1.8 -1.3 -0.8
Whole body fat mass 2.5 10.6 19.3 -4.4 1.4
Leg fat mass (right) 2.4 9.5 15.8 -4.0 1.8
Arm predicted mass (right) 0.7 3.5 3.6 -1.9 1.9
Pulse rate, automated reading 2.0 6.5 10.9 -3.3 -1.4
Alcohol intake frequency. 1.1 2.6 5.0 -2.2 -0.4
Comparative height size at age 10 0.4 2.3 2.5 1.4 1.6
Number of full sisters 1.7 2.1 3.3 -1.8 -0.9
Suffer from ‘nerves’ 0.6 0.9 1.7 -0.2 1.3
Overall health rating 2.6 5.5 11.0 -0.2 3.3
Chest pain or discomfort 2.8 4.0 7.6 -2.8 0.6
Had major operations 3.0 3.5 4.1 -1.7 -2.0
Age at last live birth 0.1 0.2 0.4 -0.6 0.0
Family relationship satisfaction 0.0 0.0 0.0 -0.0 0.2
Leg pain on walking 0.1 0.1 0.1 -0.4 -0.0
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 0.5 -0.7 -0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.8 -0.2 -0.9
Illness, injury, bereavement, stress in last 2 years 1.2 1.4 2.6 -0.5 -1.6
Medication: Aspirin 0.5 0.6 0.9 1.0 -0.5
Supplements: Vitamin C 0.6 0.7 0.7 0.8 0.8
Knee pain experienced in last month 1.4 2.1 3.9 -0.6 2.0
Hypertension (Self-reported) 1.1 3.1 6.0 -0.5 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 2.9 -1.7 -1.0
Illnesses of father: Heart disease 0.7 0.9 1.7 1.3 0.3
Illnesses of siblings: Diabetes 1.5 1.9 3.5 -0.4 -1.9
Smoking status: Previous 0.4 0.6 0.9 -1.0 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.6 0.7 -0.6
Whole body fat-free mass 0.7 3.8 4.4 -1.8 2.1
Leg fat-free mass (right) 0.7 4.0 5.4 -2.3 1.6
Arm fat percentage (left) 2.5 10.0 18.8 -4.3 1.1
Average weekly red wine intake 1.3 1.9 3.2 1.8 -0.7
Handedness (chirality/laterality): Left-handed 2.1 2.5 3.5 1.2 1.9
Mood swings 1.3 2.4 4.7 -0.3 2.2
Loneliness, isolation 1.2 1.7 3.3 -0.4 1.8
Long-standing illness, disability or infirmity 0.5 0.7 1.3 -0.2 1.2
Ever had bowel cancer screening 0.4 0.5 0.9 -1.0 0.2
Diabetes diagnosed by doctor 0.8 1.3 1.9 -1.4 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 2.7 -0.3 1.6
Friendships satisfaction 0.1 0.1 0.2 0.0 0.4
Qualifications: nursing, teaching 0.5 0.8 1.5 -0.1 -1.2
Commuting to job workplace: Walk 0.1 0.1 0.2 -0.4 -0.3
Eye problems/disorders: Cataract 0.8 0.9 1.3 0.8 -1.1
Mouth/teeth dental problems: Mouth ulcers 1.6 2.6 5.1 0.2 -2.3
Medication for cholesterol 0.7 1.1 1.7 1.3 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.8 2.4 -1.1 -1.5
Back pain experienced in last month 2.8 4.1 8.2 -0.2 2.9
Mineral and other dietary supplements 1.8 2.4 4.7 -2.2 -0.4
Breast cancer (self-reported) 0.4 0.5 0.6 -0.8 -0.6
Asthma (self-reported) 0.8 1.6 3.1 -1.8 -0.1
Osteoporosis (self-reported) 0.1 0.1 0.2 0.5 0.1
Osteoarthritis (self-reported) 0.4 0.5 0.9 -0.9 -0.4
Medication: Aspirin 0.5 0.6 1.1 1.1 -0.3
Medication: Gliclazide 0.1 0.1 0.2 0.0 -0.5
Illnesses of father: None of the above (group 1) 0.6 0.7 1.3 -1.2 0.2
Smoking status: Current 0.3 0.4 0.5 -0.7 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.5 4.9 -0.2 -2.2
Whole body water mass 0.7 3.8 4.1 -1.9 2.0
Leg predicted mass (right) 0.8 4.1 5.5 -2.4 1.6
Arm fat mass (left) 2.8 11.4 21.5 -4.6 1.1
Number of self-reported non-cancer illnesses 0.7 1.3 2.5 0.2 1.6
Average weekly champagne plus white wine intake 0.0 0.0 0.0 -0.2 0.1
Miserableness 0.7 1.2 1.8 -0.8 1.4
Guilty feelings 0.5 0.7 1.1 -1.0 -0.6
Wears glasses or contact lenses 0.8 1.0 1.4 -1.2 -0.7
Ever taken oral contraceptive pill 0.2 0.2 0.3 -0.6 -0.2
Hearing aid user 6.7 7.5 14.2 0.9 3.8
Mother’s age at death 0.1 0.1 0.1 -0.1 -0.4
Financial situation satisfaction 2.0 2.5 4.9 0.3 2.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.3 -1.1 0.2
Commuting to job workplace: Public transport 0.2 0.2 0.3 0.4 0.6
Eye problems/disorders: Glaucoma 0.9 1.0 1.6 -1.3 0.6
Medication: Blood pressure 1.0 1.9 3.0 -0.9 1.7
Pain type(s) experienced in last month: Hip pain 3.0 3.8 6.2 -2.5 1.1
Supplements: Fish oil (including cod liver oil) 0.6 0.8 1.4 1.2 0.4
High cholesterol (Self-reported) 0.3 0.5 1.0 -1.0 0.0
Medication: Bendroflumethiazide 0.5 0.7 1.4 0.2 1.2
Medication: Paracetamol 0.2 0.4 0.6 -0.8 -0.4
Medication: Lisinopril 1.0 1.3 2.4 -0.3 -1.6
Medication: Atorvastatin 0.6 0.8 1.5 -1.2 -0.2
Illnesses of father: High blood pressure 3.4 4.2 5.4 2.3 1.7
Alcohol drinker status: Never 1.5 1.8 2.7 -0.9 1.6
Ever smoked 1.4 2.5 5.0 0.1 2.2
Basal metabolic rate 1.0 5.3 6.5 -2.5 2.1
Leg fat percentage (left) 1.9 6.8 12.9 -3.6 0.8
Arm fat-free mass (left) 0.8 4.3 6.5 -2.5 1.5
Number of operations (self-reported) 0.4 0.6 1.0 -1.0 -0.4
Average weekly beer plus cider intake 3.7 5.3 8.3 1.5 2.9
Irritability 1.7 2.9 5.3 0.6 2.3
Risk taking 0.8 1.2 2.3 1.5 -0.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 -0.0 -0.5
Fractured/broken bones in last 5 years 1.3 1.7 2.9 -1.7 -0.8
Age started oral contraceptive pill 0.2 0.3 0.5 0.1 -0.7
Diastolic blood pressure, automated reading 0.4 1.3 2.5 0.1 1.6
Ever depressed for a whole week 1.5 1.9 3.1 -0.8 -1.8
Unable to work because of sickness or disability 0.3 0.4 0.8 -0.4 0.9
Commuting to job workplace: Cycle 1.9 2.3 4.7 2.2 0.2
Myopia 2.0 2.8 4.6 1.0 2.1
Vascular/heart problems diagnosed by doctor 0.7 2.0 3.8 0.4 -1.9
Cholesterol lowering medication 1.2 1.8 3.6 -1.9 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.1 -0.4
Pain experienced in last month 3.0 5.0 10.0 0.3 -3.2
Supplements: Calcium 0.1 0.1 0.2 0.5 -0.2
Basal cell carcinoma (self-reported) 1.9 2.3 3.6 1.0 1.9
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 0.7 -0.3
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.7 0.2 1.6
Heart disease (siblings) 2.9 3.5 3.6 -1.9 -1.9
Alcohol drinker status: Previous 0.4 0.5 1.0 0.1 -1.0
Pack years of smoking 0.5 0.8 1.0 0.7 1.0
Impedance of whole body 0.1 0.4 0.6 0.8 -0.3
Leg fat mass (left) 2.5 9.7 16.5 -4.1 1.7
Arm predicted mass (left) 0.9 4.7 6.9 -2.6 1.6