Hub : Genes

MAF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.2080	0.0600	1.1e-05	0.098	NA	0.160	NA	0.122	4.2e-05	NA	1.4e-07	NA	4.9e-06
2	GTEx	Whole Blood	0.0660	0.0250	2.2e-04	0.059	NA	0.047	NA	0.061	4.0e-06	NA	3.6e-05	NA	2.7e-06
3	ROSMAP	Brain Pre-frontal Cortex	0.0642	0.0232	4.2e-06	0.040	0.049	0.029	0.047	0.040	5.8e-06	6.4e-07	1.0e-04	1.1e-06	6.9e-06
4	YFS	Blood	0.0971	0.0203	0.0e+00	0.136	0.138	0.135	0.141	0.134	4.1e-42	7.8e-43	5.4e-42	7.0e-44	1.7e-41
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0172	0.0116	3.7e-03	0.025	0.013	0.015	NA	0.018	6.8e-04	1.1e-02	7.9e-03	NA	3.2e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.2	-0.3	0.5	-0.5	-0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.7	-0.2	0.5	-0.3	-0.2
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.0	0.0	-0.3	0.6	0.5
Depression (Nagel 2018)	0.7	1.0	2.1	-1.4	-1.0	0.2	-1.0	-1.0
Intelligence (Savage-Jansen 2018)	5.6	17.3	21.2	4.4	3.7	-3.4	4.6	4.6
Neuroticism (Nagel 2018)	0.7	1.6	2.3	1.0	1.0	-1.5	1.4	1.3
Schizophrenia (2018)	0.1	0.1	0.7	0.8	0.0	0.3	0.0	0.1
Schizophrenia vs Biploar Disorder	1.0	1.3	6.7	0.0	0.0	0.0	2.6	0.0
Worry (Nagel 2018)	0.4	0.7	2.2	0.7	0.2	-1.5	0.7	0.6
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.3	-0.1	0.6	-0.4	-0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.5	-0.7	-0.5	-0.1	-0.6	-0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	-0.8	-0.7	0.6	-1.1	-0.9
Crohns Disease (2017)	0.5	1.2	2.4	-0.7	-0.6	1.2	-1.6	-1.1
Irritable Bowel Disease (IBD)	0.4	1.0	2.0	-0.5	-0.5	1.1	-1.4	-1.1
Ulcerative Colitis (UC)	0.0	0.0	0.0	0.0	-0.0	0.1	-0.2	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.1	0.2	0.8	-0.1	-0.1	0.9	-0.3	-0.2
Verbal and Numeric Reasoning (VNR)	5.3	12.7	16.6	3.5	2.9	-3.2	4.1	4.0
Breast Cancer	0.2	0.5	1.7	-1.3	0.2	0.6	-0.3	-0.5
Ovarian Cancer	0.1	0.1	0.2	0.3	0.2	0.2	0.5	0.4
Prostate Cancer	2.2	3.0	3.8	1.2	1.9	-1.9	1.7	1.8
Age at First Birth	0.0	0.0	0.1	-0.1	0.3	-0.4	-0.1	-0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	0.0	0.0	-0.6	0.6	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.9	1.5	2.3	1.3	1.4	-1.5	1.2	0.0
Mean Putamen Volume	0.8	0.9	1.9	1.4	0.9	-0.4	0.8	0.9
Fasting Glucose	4.3	5.1	5.7	2.4	2.3	-2.3	2.1	2.1
HbA1C	0.2	0.2	0.6	-0.8	-0.1	0.2	-0.5	-0.3
HDL Cholesterol	0.4	0.6	1.6	-0.4	-0.8	1.3	-0.8	0.0
LDL Cholesterol	0.7	1.0	2.4	-0.8	-1.3	0.7	-1.6	0.0
Lupus	0.2	0.2	1.1	0.3	-0.0	-1.0	0.0	0.1
Neuroticism (2016)	0.1	0.1	0.3	0.1	0.0	-0.4	0.5	0.3
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.0	0.0	-0.6	-0.3	0.0
Rheumatoid Arthritis	0.1	0.2	0.6	0.3	-0.0	-0.7	0.3	0.0
Schizophrenia (2014)	0.5	1.1	3.3	1.8	0.7	-0.9	0.8	0.6
Triglycerides	0.1	0.1	0.4	-0.2	0.2	-0.6	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.1	0.1	0.3	-0.1	-0.3	-0.3	-0.6	0.0
Blood Eosinophil Count	2.8	21.5	25.5	-4.4	-4.7	4.0	-5.0	-5.0
Blood Platelet Count	8.0	92.2	110.2	-9.4	-10.3	8.7	-10.5	-9.0
Blood Red Count	2.0	19.6	23.6	4.7	4.2	-4.0	4.9	4.4
Blood White Count	1.5	11.1	14.0	-3.6	-3.0	2.6	-3.7	-3.6
Heel T-Score	0.0	0.2	0.5	0.7	0.1	-0.5	0.5	0.4
BMI	1.2	7.2	11.0	-3.3	-2.4	2.3	-2.6	-2.7
Height	2.1	40.3	61.3	4.3	6.6	-7.8	6.7	5.7
Waist Hip Ratio (WHR)	4.4	19.9	26.5	4.0	4.1	-5.1	4.6	4.4
Systolic Blood Pressure	0.8	4.2	8.4	1.1	1.6	-2.9	2.2	2.1
Smoking Status	0.5	1.1	1.8	0.6	1.3	-1.2	0.9	1.1
Allergy or Eczema	0.2	0.5	0.7	0.8	0.3	-0.8	0.7	0.8
Cardiovascular Disease	0.7	2.2	2.9	1.7	1.2	-1.3	1.7	1.6
Hypothyroidism (self reported)	0.1	0.1	0.4	0.1	0.5	0.6	0.0	-0.2
Respiratory disease	0.1	0.3	0.9	-0.9	0.3	0.0	-0.4	-0.5
Type 2 Diabetes (T2D) (2018)	1.8	3.5	4.2	2.0	2.0	-2.0	1.6	1.6
Lung FEV1/FVC ratio	0.1	0.4	0.6	-0.2	-0.5	0.8	-0.7	-0.7
Lung FVC	1.4	7.0	11.4	-2.5	-2.3	3.4	-2.5	-2.4
Neuroticism	0.1	0.2	0.8	-0.2	-0.4	-0.9	0.3	0.2
Chronotype (morning person)	0.2	0.4	0.7	-0.1	-0.8	-0.0	-0.8	-0.7
Hair Pigment	0.0	0.3	0.3	-0.6	-0.6	-0.5	-0.5	-0.4
Tanning	0.0	0.1	0.3	-0.2	0.5	0.0	0.2	-0.2
Hand grip strength (left)	0.3	0.7	1.5	0.1	0.9	-1.2	0.8	0.9
Number of treatments/medications taken	1.1	2.0	3.6	-1.9	-1.6	0.3	-1.3	-1.4
Average weekly spirits intake	2.0	2.5	4.1	-2.0	-1.3	1.0	-1.7	-1.7
Sensitivity / hurt feelings	0.0	0.1	0.3	-0.5	0.0	0.2	0.1	0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.6	-0.3	-0.1	-0.5	-0.5
Hearing difficulty/problems: Yes	4.0	6.1	8.3	1.8	2.5	-2.2	2.8	2.9
Relative age of first facial hair	2.6	5.4	10.1	3.2	1.8	-1.9	2.4	2.0
Other serious medical condition/disability diagnosed by doctor	5.3	6.9	10.2	-2.0	-2.3	2.4	-3.0	-3.2
Ever used hormone-replacement therapy (HRT)	4.1	5.3	6.7	-2.4	-2.1	1.8	-2.6	-2.5
Ever had hysterectomy (womb removed)	5.6	6.3	8.9	2.5	2.2	-3.0	2.4	2.4
Systolic blood pressure, automated reading	0.3	0.8	2.9	-0.3	0.3	-1.7	0.7	0.7
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.3	-0.1	0.4	-0.0	0.0
Angina	0.8	1.1	1.9	-1.4	-1.0	0.2	-1.1	-1.1
Medication for hormone replacement therapy	4.4	4.9	5.3	-2.3	-2.0	2.2	-2.3	-2.3
Vitamin and mineral supplements	2.3	3.1	3.9	-1.6	-1.9	1.5	-2.0	-1.9
Supplements: Zinc	1.3	1.4	2.0	0.7	1.1	-1.4	1.2	1.3
Medication: Co-codamol	0.5	0.6	1.2	-0.9	-1.1	0.0	-0.7	-0.7
Medication: Metformin	0.6	0.9	2.5	0.8	0.9	-1.6	0.6	0.6
Diabetes (father)	0.5	0.6	1.8	0.5	0.5	-1.3	0.6	0.5
Diabetes (mother)	0.7	0.9	1.5	-0.6	-1.2	0.7	-1.2	-1.0
Severe depression (siblings)	0.3	0.3	0.5	0.7	0.6	-0.2	0.6	0.7
Pack years adult smoking proportion	0.2	0.3	0.6	0.1	0.3	-0.8	0.6	0.6
Impedance of leg (right)	1.3	6.4	9.5	2.0	2.4	-3.1	2.5	2.5
Leg fat-free mass (left)	0.0	0.2	0.4	-0.1	0.1	-0.6	0.6	0.1
Trunk fat percentage	0.2	0.8	2.2	-1.5	-0.9	-0.2	-0.6	-0.7
Hand grip strength (right)	1.7	4.6	5.9	2.0	2.2	-1.6	2.4	2.3
Townsend deprivation index at recruitment	0.7	1.0	2.5	-0.4	-0.9	1.6	-0.8	-0.8
Current tobacco smoking	1.0	1.6	2.5	1.2	1.6	-1.0	1.2	1.3
Average weekly fortified wine intake	4.3	5.0	6.6	2.6	2.3	-2.1	2.3	1.9
Maternal smoking around birth	1.3	1.8	6.3	0.9	0.6	-2.5	1.0	0.8
Fed-up feelings	0.4	0.8	1.4	-0.6	-1.0	1.2	-0.6	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.5	-0.7	-0.4	0.1	-0.5	-0.5
Relative age voice broke	2.4	3.6	6.3	2.5	1.9	-1.7	1.8	1.5
Taking other prescription medications	2.2	3.5	6.2	-2.5	-1.7	1.2	-1.8	-1.8
Age when periods started (menarche)	1.5	3.7	5.2	1.8	1.8	-2.3	1.9	1.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.1	0.1	0.6	-0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	1.3	0.5	0.2	0.5	0.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.6	-0.3	-0.0	-1.3	0.6	0.3
Qualifications: CSEs or equivalent	0.4	0.5	1.0	-0.3	-0.6	1.0	-0.7	-0.8
Serious illness, injury or assault to yourself	1.5	1.9	2.9	-1.7	-1.2	0.9	-1.6	-1.3
High blood pressure	0.4	1.1	1.7	0.7	0.8	-1.1	1.3	1.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.4	1.2	0.7	-0.6	1.0	1.0
Multivitamins +/- minerals	2.5	3.2	3.7	1.6	1.6	-1.9	1.9	1.9
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.7	-0.2	0.4	-0.0	-0.2
Supplements: Glucosamine	0.9	1.2	2.0	0.7	0.8	-1.1	1.4	1.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	-0.3	-0.4	0.8	-0.2	-0.4
Medication: Atenolol	0.2	0.2	0.7	0.5	-0.0	-0.8	0.4	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.4	-0.3	0.7	0.0	-0.0	-0.0
Sitting height	1.2	8.4	15.9	2.5	2.6	-4.0	2.9	2.2
Chronic bronchitis/emphysema (father)	1.6	1.9	2.9	-1.7	-1.2	1.0	-1.4	-1.4
High blood pressure (mother)	5.7	8.0	9.1	-2.8	-3.0	2.8	-2.8	-2.7
Body mass index (BMI)	1.3	5.5	6.8	-2.6	-2.3	2.3	-2.2	-2.3
Impedance of leg (left)	1.5	7.1	8.8	2.2	2.8	-3.0	2.7	2.7
Leg predicted mass (left)	0.0	0.1	0.4	-0.2	0.1	-0.6	0.5	0.1
Trunk fat mass	0.1	0.6	1.8	-1.4	-0.7	-0.4	-0.3	-0.6
Waist circumference	0.0	0.1	0.2	-0.1	0.1	-0.3	0.4	0.2
Number of incorrect matches in round	2.8	4.7	5.8	-1.8	-2.2	2.2	-2.2	-2.4
Past tobacco smoking	0.0	0.1	0.3	0.5	0.0	-0.3	0.2	0.1
Alcohol usually taken with meals	0.1	0.2	1.1	-0.2	-1.0	0.1	-0.2	-0.2
Nervous feelings	1.4	2.7	3.8	1.9	1.3	-1.4	1.8	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.1	-1.0	-1.1	0.8	-1.1	-0.9
Hearing difficulty/problems with background noise	2.3	3.6	5.7	1.1	2.4	-1.8	2.0	2.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.5	0.6	-0.4	0.4	0.3
Had menopause	1.5	1.8	2.4	-0.9	-1.2	1.4	-1.5	-1.6
Had other major operations	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.3	-0.4
Forced vital capacity (FVC)	0.1	0.5	0.8	0.7	0.9	-0.3	0.9	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	6.1	2.5	1.7	-0.5	1.7	1.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	-0.4	-0.7	0.6	-0.4	-0.4
Qualifications: None of the above	0.6	1.2	2.5	-0.8	-1.0	1.6	-1.1	-0.9
Financial difficulties in last 2 years	4.0	5.4	9.9	-3.1	-2.3	1.4	-2.2	-2.2
Mouth/teeth dental problems	0.2	0.4	0.6	-0.6	-0.3	0.5	-0.8	-0.7
Heart attack	0.3	0.3	0.5	-0.5	-0.7	0.1	-0.7	-0.7
Allergy	0.0	0.1	0.2	-0.3	-0.5	-0.1	-0.4	-0.3
Pain all over the body in last month	1.2	1.3	2.4	-1.6	-1.0	0.6	-1.1	-1.3
Diabetes (self-reported)	1.2	1.9	2.6	1.6	1.6	-1.4	1.2	1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-0.2	-0.7	1.0	-0.7	-0.8
Medication: Ramipril	0.2	0.3	0.8	0.9	-0.5	-0.4	0.5	0.3
Medication: Simvastatin	0.1	0.1	0.2	0.2	0.4	-0.3	-0.1	0.2
Fluid intelligence score	4.3	9.0	11.6	3.0	2.4	-2.8	3.4	3.3
Illnesses of siblings	0.5	0.7	1.8	1.1	1.3	-0.4	0.5	0.5
Neuroticism score	0.2	0.4	0.8	0.3	0.1	-0.9	0.9	0.8
Weight	0.0	0.1	0.4	-0.6	-0.0	-0.5	0.2	-0.2
Impedance of arm (right)	0.5	2.3	6.0	1.4	0.7	-2.5	1.2	1.3
Arm fat percentage (right)	1.2	4.7	6.7	-2.6	-2.4	1.5	-2.1	-2.1
Trunk fat-free mass	0.4	2.5	3.8	1.0	1.8	-1.7	2.0	1.4
Hip circumference	0.3	1.1	1.4	-1.2	-1.1	1.1	-0.8	-1.1
Time employed in main current job	0.5	0.5	0.8	-0.5	-0.9	0.9	-0.7	-0.6
Alcohol intake versus 10 years previously	1.2	1.8	3.8	-1.6	-0.7	1.9	-1.1	-0.9
Father’s age at death	0.5	0.6	1.6	-1.3	-0.5	0.1	-0.8	-0.7
Worrier / anxious feelings	0.0	0.1	0.2	0.0	-0.2	-0.5	0.1	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.2	0.2	-0.4	0.4	0.3
Falls in the last year	0.1	0.1	0.3	0.3	-0.5	0.4	-0.1	-0.2
Hair/balding pattern: Pattern 3	0.0	0.1	0.2	-0.2	-0.5	0.1	-0.1	-0.1
Number of live births	0.9	1.3	1.8	-0.6	-1.4	1.2	-1.1	-1.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.1	0.4	0.1	0.3	0.2	0.1
Pulse rate	0.8	1.4	3.2	-1.8	-0.8	0.1	-1.2	-1.2
Happiness	0.2	0.2	0.4	-0.2	-0.6	0.6	-0.3	-0.3
Noisy workplace	0.8	0.9	3.1	-0.5	-0.8	1.8	-0.7	-0.5
Qualifications: A levels/AS levels or equivalent	4.3	9.4	10.6	3.2	2.9	-2.7	3.3	3.2
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.0	0.8	0.7	-0.5	1.0	0.9
Mouth/teeth dental problems: Dentures	0.3	0.4	1.5	-1.2	-0.3	0.7	-0.3	-0.2
Asthma	0.5	1.0	2.2	-1.5	-0.2	0.7	-0.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.3	-0.0	-0.6	0.1	0.1
Medication: Cholesterol lowering	2.2	3.4	4.9	-2.2	-1.7	1.0	-2.2	-1.8
Depression (self-reported)	0.2	0.2	0.4	-0.2	0.4	-0.2	0.5	0.7
Medication: Lansoprazole	0.4	0.4	1.2	-0.3	1.1	-0.3	0.5	0.6
Prospective memory result	1.0	1.3	1.7	-0.9	-0.9	1.3	-1.3	-1.2
Lung cancer (father)	0.0	0.0	0.0	0.1	0.2	0.1	0.0	0.1
Illnesses of mother	1.3	1.6	2.8	1.1	1.7	-1.2	1.3	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.2	-0.1	-0.4	0.5	-0.0	-0.2
Pulse wave Arterial Stiffness index	0.6	0.7	1.3	-1.2	-0.8	0.6	-0.8	-0.8
Impedance of arm (left)	0.4	2.0	5.3	1.3	0.6	-2.3	1.1	1.2
Arm fat mass (right)	0.5	2.0	3.6	-1.9	-1.5	0.9	-1.2	-1.4
Trunk predicted mass	0.4	2.1	3.4	0.9	1.6	-1.6	1.8	1.2
Standing height	2.3	23.3	33.7	3.9	4.7	-5.8	5.2	4.3
Length of working week for main job	1.4	1.6	3.1	-1.8	-1.1	1.1	-1.1	-1.0
Exposure to tobacco smoke at home	3.8	4.3	5.8	-1.9	-2.4	1.6	-2.2	-2.1
Breastfed as a baby	0.7	0.9	1.5	0.5	1.2	-1.0	0.7	1.0
Tense / ‘highly strung’	1.4	2.4	3.8	1.3	1.3	-1.9	1.6	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.8	0.7	1.4	-0.4	1.0	1.3
Hair/balding pattern: Pattern 4	2.7	6.6	11.0	-3.3	-2.5	1.8	-2.5	-2.6
Birth weight of first child	1.9	3.5	5.9	1.7	1.6	-2.4	1.8	1.8
Peak expiratory flow (PEF)	0.2	0.4	1.5	1.2	0.2	-0.3	0.3	0.1
Pulse wave reflection index	0.3	0.3	0.5	0.6	0.5	-0.7	0.4	0.5
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.1	-0.1	-0.3	-0.0	-0.1	-0.1
Loud music exposure frequency	0.2	0.2	0.5	0.7	0.0	0.4	0.4	0.3
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	6.1	2.5	1.1	-1.7	1.8	1.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	0.6	-0.3	-1.2	0.1	-0.0
Blood clot in the leg (DVT)	1.9	2.5	3.4	-1.7	-1.8	1.3	-1.5	-1.5
Medication: Paracetamol	0.1	0.2	0.7	-0.1	0.0	-0.9	0.0	-0.1
Headache pain in last month	0.0	0.0	0.1	-0.0	0.1	-0.4	0.1	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.4	1.2	0.3	0.5	0.1	-0.0
Glaucoma (self-reported)	0.1	0.1	0.1	-0.3	-0.2	-0.3	-0.3	-0.3
Gout (self-reported)	0.3	0.4	1.0	0.3	1.0	0.2	0.6	0.6
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.2	0.1	0.6	-0.4	-0.5
Medication: Amlodipine	0.9	1.3	1.7	0.7	1.3	-1.3	1.1	1.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	-0.6	0.6	0.1	0.1	-0.0
Birth weight	1.5	3.3	5.2	1.8	2.3	-1.0	1.8	1.9
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.0	0.4	-0.5	0.4	0.4
High blood pressure (siblings)	0.7	1.0	1.5	-1.0	-1.2	0.9	-0.9	-0.9
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	0.2	0.1	-0.1	0.4	0.2
Body fat percentage	0.4	1.5	3.5	-1.9	-1.2	0.4	-1.0	-1.1
Leg fat percentage (right)	0.5	1.7	4.2	-2.0	-1.2	0.8	-1.1	-1.1
Arm fat-free mass (right)	0.4	2.0	3.1	0.7	1.7	-1.5	1.8	1.2
Exposure to tobacco smoke outside home	0.1	0.1	0.2	0.1	-0.5	0.2	-0.2	-0.3
Comparative body size at age 10	0.1	0.2	0.6	-0.4	-0.6	0.8	-0.1	-0.1
Number of full brothers	0.1	0.1	0.2	0.5	0.1	-0.3	-0.3	-0.3
Worry too long after embarrassment	2.1	3.6	4.7	1.1	2.0	-2.0	2.2	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.3	0.7	-0.0	0.6	0.7
Wheeze or whistling in the chest in last year	0.0	0.1	0.1	0.1	0.3	0.2	-0.2	-0.3
Number of children fathered	0.6	0.7	1.8	-1.3	-0.7	-0.0	-0.9	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.5	1.1	1.2	-0.2	0.9	0.8
Age at first live birth	0.7	1.2	1.9	1.0	1.0	-0.9	1.2	1.4
Pulse wave peak to peak time	0.9	1.1	1.7	1.3	0.9	-0.9	1.0	1.0
Health satisfaction	0.1	0.1	0.2	0.2	-0.1	-0.2	0.4	0.4
Shortness of breath walking on level ground	0.8	0.9	1.4	0.7	1.0	-0.6	1.2	1.2
Qualifications: College or University degree	1.4	4.4	6.2	2.2	1.6	-2.5	2.1	1.9
Eye problems/disorders: None of the above	1.4	1.6	3.6	-0.0	-1.3	1.9	-1.2	-1.2
Mouth/teeth dental problems: Loose teeth	1.5	1.8	3.4	-0.4	-1.1	1.8	-1.3	-1.6
Emphysema/chronic bronchitis	2.5	2.8	3.9	1.6	2.0	-1.6	1.6	1.6
Medication for pain relief, constipation, heartburn	0.6	1.0	1.9	1.1	1.4	-0.2	0.9	0.9
Neck or shoulder pain in last month	0.2	0.3	0.8	0.0	-0.5	0.9	-0.4	-0.5
Medication: Blood pressure	0.3	0.5	1.4	-0.7	0.2	-1.2	0.6	0.5
Angina (self-reported)	0.9	1.2	2.1	-1.4	-1.1	0.2	-1.2	-1.2
Migraine (self-reported)	0.5	0.7	1.7	-1.3	-0.8	0.5	-0.7	-0.6
Medication: Ibuprofen	0.4	0.5	1.2	-1.1	-0.7	-0.1	-0.6	-0.6
Medication: Allopurinol	0.7	0.9	1.9	1.1	1.4	-0.1	0.8	0.8
Medication: Omeprazole	1.1	1.3	2.4	-1.0	-1.6	0.9	-1.1	-1.2
Medication: Seretide 50 evohaler	0.0	0.1	0.2	-0.2	-0.0	-0.4	-0.2	0.0
Mean time to correctly identify matches	0.1	0.1	0.5	0.0	0.0	0.7	-0.2	-0.1
Heart disease (mother)	0.1	0.1	0.2	-0.0	-0.4	0.2	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.3	0.9	1.1	-0.9	0.7	0.8
Whole body fat mass	0.2	0.9	2.7	-1.6	-0.8	0.2	-0.6	-0.9
Leg fat mass (right)	0.3	1.0	3.0	-1.7	-0.9	0.3	-0.6	-0.8
Arm predicted mass (right)	0.3	1.6	2.6	0.5	1.6	-1.3	1.6	1.1
Pulse rate, automated reading	0.2	0.6	1.5	-0.3	0.9	-1.2	0.5	0.3
Alcohol intake frequency.	0.1	0.2	0.6	0.4	-0.5	0.7	-0.0	0.1
Comparative height size at age 10	1.6	8.6	14.4	2.1	2.7	-3.8	3.2	2.6
Number of full sisters	0.1	0.1	0.3	-0.3	0.5	0.1	0.1	0.3
Suffer from ‘nerves’	0.1	0.2	0.6	-0.8	-0.2	0.3	-0.3	-0.3
Overall health rating	0.4	0.9	2.0	-0.4	-0.8	1.4	-0.9	-1.0
Chest pain or discomfort	1.0	1.5	2.2	1.5	1.3	-1.2	1.0	1.0
Had major operations	2.3	2.7	4.9	-1.3	-2.2	1.2	-1.6	-1.6
Age at last live birth	0.9	1.4	2.0	1.2	0.8	-1.1	1.3	1.4
Family relationship satisfaction	0.0	0.0	0.1	0.2	0.2	0.0	0.2	0.1
Leg pain on walking	0.4	0.5	0.9	-1.0	-0.9	0.5	-0.6	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-0.8	-1.1	1.1	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	-0.6	-0.8	0.6	-0.6	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.8	0.5	-0.7	0.6	0.5
Medication: Aspirin	0.5	0.6	1.3	-1.1	-0.9	-0.1	-0.7	-0.7
Supplements: Vitamin C	4.2	5.0	7.0	1.8	2.6	-2.1	2.3	2.3
Knee pain experienced in last month	0.3	0.4	1.1	0.2	0.8	-1.0	0.4	0.4
Hypertension (Self-reported)	0.5	1.4	2.1	0.9	1.0	-1.2	1.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	-0.6	-1.0	0.7	-0.5	-0.6
Illnesses of father: Heart disease	0.0	0.0	0.2	0.4	-0.1	0.1	0.1	0.1
Illnesses of siblings: Diabetes	0.5	0.6	1.1	-1.1	-0.3	-0.0	-0.9	-0.9
Smoking status: Previous	0.3	0.4	0.8	-0.9	-0.4	0.6	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.7	0.7	1.0	-1.3	1.0	0.7
Whole body fat-free mass	0.2	1.2	2.1	0.5	1.1	-1.2	1.4	0.9
Leg fat-free mass (right)	0.0	0.2	0.5	0.1	0.3	-0.7	0.7	0.3
Arm fat percentage (left)	1.1	4.4	6.2	-2.5	-2.3	1.5	-2.0	-2.0
Average weekly red wine intake	3.9	5.7	7.1	2.3	2.3	-2.3	2.7	2.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	-1.1	-0.7	0.1	-0.8	-0.5
Mood swings	0.1	0.2	0.4	-0.6	-0.3	0.4	-0.5	-0.6
Loneliness, isolation	0.0	0.1	0.1	-0.1	0.3	0.2	0.3	0.4
Long-standing illness, disability or infirmity	0.5	0.7	1.7	-1.3	-0.5	0.2	-1.0	-0.8
Ever had bowel cancer screening	0.6	0.7	1.5	-1.2	-0.4	0.1	-1.0	-0.8
Diabetes diagnosed by doctor	1.3	2.1	2.7	1.6	1.6	-1.6	1.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	2.8	2.9	4.8	1.7	2.2	-1.8	1.4	1.4
Friendships satisfaction	0.6	0.7	1.6	1.3	0.5	-0.0	0.9	0.8
Qualifications: nursing, teaching	0.3	0.5	1.1	1.0	0.4	-0.9	0.5	0.5
Commuting to job workplace: Walk	4.2	4.6	6.4	2.5	1.9	-1.8	2.2	2.1
Eye problems/disorders: Cataract	0.4	0.4	1.7	-0.5	0.4	-1.3	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	6.8	10.8	13.7	3.7	2.9	-3.2	3.4	3.2
Medication for cholesterol	0.4	0.6	1.0	0.4	0.8	-1.0	0.8	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	2.6	-1.4	-1.6	-0.2	-1.4	-1.2
Back pain experienced in last month	1.0	1.4	3.7	-1.9	-0.7	1.1	-1.0	-0.9
Mineral and other dietary supplements	0.8	1.1	1.8	-0.9	-0.8	0.8	-1.3	-1.2
Breast cancer (self-reported)	1.2	1.4	2.0	0.8	1.2	-1.4	1.2	1.2
Asthma (self-reported)	0.3	0.7	2.0	-1.4	0.1	0.6	-0.7	-0.8
Osteoporosis (self-reported)	1.9	2.4	3.4	-1.3	-1.2	1.8	-1.7	-1.6
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.5	0.4	-0.1	0.3	0.4
Medication: Aspirin	1.2	1.6	3.0	-1.7	-1.4	0.2	-1.2	-1.2
Medication: Gliclazide	0.5	0.6	0.9	-1.0	-0.7	0.0	-0.8	-0.9
Illnesses of father: None of the above (group 1)	0.6	0.7	0.9	1.0	0.9	-0.3	1.0	0.9
Smoking status: Current	1.3	2.0	3.2	1.3	1.8	-1.2	1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.7	-0.4	-0.8	0.8	-0.7	-0.5
Whole body water mass	0.2	1.0	1.8	0.5	1.1	-1.1	1.4	0.8
Leg predicted mass (right)	0.0	0.2	0.4	0.0	0.3	-0.6	0.6	0.2
Arm fat mass (left)	0.7	3.0	4.8	-2.2	-1.8	1.2	-1.6	-1.7
Number of self-reported non-cancer illnesses	0.3	0.5	0.9	-0.7	-0.7	1.0	-0.6	-0.7
Average weekly champagne plus white wine intake	0.5	0.7	1.7	-1.3	-0.7	0.1	-0.8	-0.8
Miserableness	1.8	3.0	3.8	1.5	1.7	-1.5	2.0	2.0
Guilty feelings	0.1	0.1	0.3	0.5	0.5	0.2	0.4	0.2
Wears glasses or contact lenses	0.3	0.3	0.9	-0.0	0.9	-0.8	0.2	0.0
Ever taken oral contraceptive pill	0.4	0.4	1.2	-1.1	-0.4	-0.3	-0.6	-0.5
Hearing aid user	0.1	0.1	0.2	-0.4	-0.4	-0.0	-0.2	-0.0
Mother’s age at death	1.3	1.7	2.4	1.0	1.2	-1.2	1.5	1.4
Financial situation satisfaction	0.2	0.2	0.6	-0.8	-0.4	-0.4	-0.4	-0.4
Tinnitus: Yes, now most or all of the time	1.2	1.3	1.7	-1.1	-1.3	1.2	-1.2	-1.0
Commuting to job workplace: Public transport	2.4	2.8	3.8	1.6	1.5	-1.5	1.9	1.8
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.4	0.7	-1.0	0.4	0.4
Medication: Blood pressure	0.1	0.3	1.1	1.0	-0.1	0.1	0.4	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.1	-0.5	0.1	0.2	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	0.5	0.6	-0.4	1.0	0.9
High cholesterol (Self-reported)	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.1	-0.3	0.5	-0.0	-0.3
Medication: Paracetamol	0.5	0.7	1.1	-0.9	-0.8	-0.0	-1.0	-1.1
Medication: Lisinopril	0.2	0.3	0.6	-0.5	-0.5	0.8	-0.2	-0.5
Medication: Atorvastatin	0.0	0.0	0.2	-0.4	-0.0	-0.1	-0.1	0.1
Illnesses of father: High blood pressure	0.4	0.5	1.2	-1.1	-0.8	0.2	-0.7	-0.5
Alcohol drinker status: Never	0.3	0.4	0.7	0.6	0.5	-0.5	0.8	0.8
Ever smoked	0.1	0.2	0.5	-0.5	-0.3	0.7	-0.5	-0.3
Basal metabolic rate	0.1	0.8	1.4	0.3	0.9	-1.0	1.2	0.7
Leg fat percentage (left)	0.4	1.5	3.4	-1.8	-1.1	1.0	-1.0	-1.1
Arm fat-free mass (left)	0.2	1.0	1.8	0.4	1.2	-1.1	1.4	0.8
Number of operations (self-reported)	0.3	0.5	1.2	-1.1	-0.3	0.1	-0.8	-0.7
Average weekly beer plus cider intake	0.9	1.3	1.8	-1.2	-0.4	1.3	-1.3	-1.1
Irritability	0.7	1.2	1.8	0.5	0.8	-1.3	1.2	1.3
Risk taking	0.2	0.3	0.5	-0.3	-0.5	0.3	-0.7	-0.7
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-0.4	-1.2	0.4	-0.9	-1.0
Fractured/broken bones in last 5 years	0.0	0.0	0.1	-0.2	0.3	0.1	0.0	-0.0
Age started oral contraceptive pill	2.3	2.9	3.6	1.5	1.7	-1.9	1.7	1.7
Diastolic blood pressure, automated reading	0.2	0.6	1.7	-1.3	-0.6	-0.6	-0.5	-0.3
Ever depressed for a whole week	0.9	1.1	1.8	-1.0	-1.0	1.3	-0.9	-0.9
Unable to work because of sickness or disability	0.1	0.2	0.4	-0.6	0.5	0.1	0.3	0.4
Commuting to job workplace: Cycle	0.5	0.6	1.0	1.0	0.7	-0.7	0.9	0.8
Myopia	0.3	0.4	1.0	0.8	-0.0	-1.0	0.5	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.1	-0.3	-0.3	1.0	-0.9	-0.8
Cholesterol lowering medication	0.0	0.0	0.1	0.2	0.3	0.3	0.0	0.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.3	3.6	-1.6	-1.9	1.0	-1.5	-1.4
Pain experienced in last month	0.4	0.6	0.8	0.9	0.9	-0.9	0.7	0.6
Supplements: Calcium	0.7	0.8	2.5	0.6	0.7	-1.6	0.6	0.6
Basal cell carcinoma (self-reported)	0.1	0.1	0.3	-0.5	-0.2	-0.6	-0.1	-0.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.4	-0.6	-0.5	0.0	-0.6	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.5	3.2	4.1	-2.0	-2.0	1.5	-1.7	-1.6
Heart disease (siblings)	0.2	0.2	0.5	-0.7	-0.6	0.1	-0.2	-0.2
Alcohol drinker status: Previous	0.1	0.2	0.3	0.1	-0.5	0.6	-0.3	-0.3
Pack years of smoking	0.4	0.6	0.8	0.5	0.6	-0.8	0.9	0.9
Impedance of whole body	1.0	5.1	8.8	2.0	1.9	-3.0	2.1	2.2
Leg fat mass (left)	0.3	1.1	2.9	-1.7	-0.9	0.5	-0.7	-0.9
Arm predicted mass (left)	0.2	1.2	2.2	0.5	1.2	-1.1	1.5	1.0