Hub : Genes

MAF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.2080 0.0600 1.1e-05 0.098 NA 0.160 NA 0.122 4.2e-05 NA 1.4e-07 NA 4.9e-06
2 GTEx Whole Blood 0.0660 0.0250 2.2e-04 0.059 NA 0.047 NA 0.061 4.0e-06 NA 3.6e-05 NA 2.7e-06
3 ROSMAP Brain Pre-frontal Cortex 0.0642 0.0232 4.2e-06 0.040 0.049 0.029 0.047 0.040 5.8e-06 6.4e-07 1.0e-04 1.1e-06 6.9e-06
4 YFS Blood 0.0971 0.0203 0.0e+00 0.136 0.138 0.135 0.141 0.134 4.1e-42 7.8e-43 5.4e-42 7.0e-44 1.7e-41
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0172 0.0116 3.7e-03 0.025 0.013 0.015 NA 0.018 6.8e-04 1.1e-02 7.9e-03 NA 3.2e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.2 0.3 -0.2 -0.3 0.5 -0.5 -0.5
Bipolar Disorder or Schizophrenia 0.1 0.2 0.5 0.7 -0.2 0.5 -0.3 -0.2
Depressed Affect (Nagel 2018) 0.1 0.1 0.3 -0.0 0.0 -0.3 0.6 0.5
Depression (Nagel 2018) 0.7 1.0 2.1 -1.4 -1.0 0.2 -1.0 -1.0
Intelligence (Savage-Jansen 2018) 5.6 17.3 21.2 4.4 3.7 -3.4 4.6 4.6
Neuroticism (Nagel 2018) 0.7 1.6 2.3 1.0 1.0 -1.5 1.4 1.3
Schizophrenia (2018) 0.1 0.1 0.7 0.8 0.0 0.3 0.0 0.1
Schizophrenia vs Biploar Disorder 1.0 1.3 6.7 0.0 0.0 0.0 2.6 0.0
Worry (Nagel 2018) 0.4 0.7 2.2 0.7 0.2 -1.5 0.7 0.6
Alzheimer’s Disease (in mother) 0.1 0.1 0.4 -0.3 -0.1 0.6 -0.4 -0.2
Alzheimer’s Disease (in father) 0.3 0.3 0.5 -0.7 -0.5 -0.1 -0.6 -0.6
Alzheimer’s Disease (including proxy) 0.5 0.7 1.2 -0.8 -0.7 0.6 -1.1 -0.9
Crohns Disease (2017) 0.5 1.2 2.4 -0.7 -0.6 1.2 -1.6 -1.1
Irritable Bowel Disease (IBD) 0.4 1.0 2.0 -0.5 -0.5 1.1 -1.4 -1.1
Ulcerative Colitis (UC) 0.0 0.0 0.0 0.0 -0.0 0.1 -0.2 -0.2
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.1 0.2 0.8 -0.1 -0.1 0.9 -0.3 -0.2
Verbal and Numeric Reasoning (VNR) 5.3 12.7 16.6 3.5 2.9 -3.2 4.1 4.0
Breast Cancer 0.2 0.5 1.7 -1.3 0.2 0.6 -0.3 -0.5
Ovarian Cancer 0.1 0.1 0.2 0.3 0.2 0.2 0.5 0.4
Prostate Cancer 2.2 3.0 3.8 1.2 1.9 -1.9 1.7 1.8
Age at First Birth 0.0 0.0 0.1 -0.1 0.3 -0.4 -0.1 -0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.4 0.0 0.0 -0.6 0.6 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.9 1.5 2.3 1.3 1.4 -1.5 1.2 0.0
Mean Putamen Volume 0.8 0.9 1.9 1.4 0.9 -0.4 0.8 0.9
Fasting Glucose 4.3 5.1 5.7 2.4 2.3 -2.3 2.1 2.1
HbA1C 0.2 0.2 0.6 -0.8 -0.1 0.2 -0.5 -0.3
HDL Cholesterol 0.4 0.6 1.6 -0.4 -0.8 1.3 -0.8 0.0
LDL Cholesterol 0.7 1.0 2.4 -0.8 -1.3 0.7 -1.6 0.0
Lupus 0.2 0.2 1.1 0.3 -0.0 -1.0 0.0 0.1
Neuroticism (2016) 0.1 0.1 0.3 0.1 0.0 -0.4 0.5 0.3
Primary Biliary Cirrhosis 0.1 0.1 0.4 0.0 0.0 -0.6 -0.3 0.0
Rheumatoid Arthritis 0.1 0.2 0.6 0.3 -0.0 -0.7 0.3 0.0
Schizophrenia (2014) 0.5 1.1 3.3 1.8 0.7 -0.9 0.8 0.6
Triglycerides 0.1 0.1 0.4 -0.2 0.2 -0.6 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.1 0.1 0.3 -0.1 -0.3 -0.3 -0.6 0.0
Blood Eosinophil Count 2.8 21.5 25.5 -4.4 -4.7 4.0 -5.0 -5.0
Blood Platelet Count 8.0 92.2 110.2 -9.4 -10.3 8.7 -10.5 -9.0
Blood Red Count 2.0 19.6 23.6 4.7 4.2 -4.0 4.9 4.4
Blood White Count 1.5 11.1 14.0 -3.6 -3.0 2.6 -3.7 -3.6
Heel T-Score 0.0 0.2 0.5 0.7 0.1 -0.5 0.5 0.4
BMI 1.2 7.2 11.0 -3.3 -2.4 2.3 -2.6 -2.7
Height 2.1 40.3 61.3 4.3 6.6 -7.8 6.7 5.7
Waist Hip Ratio (WHR) 4.4 19.9 26.5 4.0 4.1 -5.1 4.6 4.4
Systolic Blood Pressure 0.8 4.2 8.4 1.1 1.6 -2.9 2.2 2.1
Smoking Status 0.5 1.1 1.8 0.6 1.3 -1.2 0.9 1.1
Allergy or Eczema 0.2 0.5 0.7 0.8 0.3 -0.8 0.7 0.8
Cardiovascular Disease 0.7 2.2 2.9 1.7 1.2 -1.3 1.7 1.6
Hypothyroidism (self reported) 0.1 0.1 0.4 0.1 0.5 0.6 0.0 -0.2
Respiratory disease 0.1 0.3 0.9 -0.9 0.3 0.0 -0.4 -0.5
Type 2 Diabetes (T2D) (2018) 1.8 3.5 4.2 2.0 2.0 -2.0 1.6 1.6
Lung FEV1/FVC ratio 0.1 0.4 0.6 -0.2 -0.5 0.8 -0.7 -0.7
Lung FVC 1.4 7.0 11.4 -2.5 -2.3 3.4 -2.5 -2.4
Neuroticism 0.1 0.2 0.8 -0.2 -0.4 -0.9 0.3 0.2
Chronotype (morning person) 0.2 0.4 0.7 -0.1 -0.8 -0.0 -0.8 -0.7
Hair Pigment 0.0 0.3 0.3 -0.6 -0.6 -0.5 -0.5 -0.4
Tanning 0.0 0.1 0.3 -0.2 0.5 0.0 0.2 -0.2
Hand grip strength (left) 0.3 0.7 1.5 0.1 0.9 -1.2 0.8 0.9
Number of treatments/medications taken 1.1 2.0 3.6 -1.9 -1.6 0.3 -1.3 -1.4
Average weekly spirits intake 2.0 2.5 4.1 -2.0 -1.3 1.0 -1.7 -1.7
Sensitivity / hurt feelings 0.0 0.1 0.3 -0.5 0.0 0.2 0.1 0.1
Frequency of depressed mood in last 2 weeks 0.1 0.2 0.3 -0.6 -0.3 -0.1 -0.5 -0.5
Hearing difficulty/problems: Yes 4.0 6.1 8.3 1.8 2.5 -2.2 2.8 2.9
Relative age of first facial hair 2.6 5.4 10.1 3.2 1.8 -1.9 2.4 2.0
Other serious medical condition/disability diagnosed by doctor 5.3 6.9 10.2 -2.0 -2.3 2.4 -3.0 -3.2
Ever used hormone-replacement therapy (HRT) 4.1 5.3 6.7 -2.4 -2.1 1.8 -2.6 -2.5
Ever had hysterectomy (womb removed) 5.6 6.3 8.9 2.5 2.2 -3.0 2.4 2.4
Systolic blood pressure, automated reading 0.3 0.8 2.9 -0.3 0.3 -1.7 0.7 0.7
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 -0.3 -0.1 0.4 -0.0 0.0
Angina 0.8 1.1 1.9 -1.4 -1.0 0.2 -1.1 -1.1
Medication for hormone replacement therapy 4.4 4.9 5.3 -2.3 -2.0 2.2 -2.3 -2.3
Vitamin and mineral supplements 2.3 3.1 3.9 -1.6 -1.9 1.5 -2.0 -1.9
Supplements: Zinc 1.3 1.4 2.0 0.7 1.1 -1.4 1.2 1.3
Medication: Co-codamol 0.5 0.6 1.2 -0.9 -1.1 0.0 -0.7 -0.7
Medication: Metformin 0.6 0.9 2.5 0.8 0.9 -1.6 0.6 0.6
Diabetes (father) 0.5 0.6 1.8 0.5 0.5 -1.3 0.6 0.5
Diabetes (mother) 0.7 0.9 1.5 -0.6 -1.2 0.7 -1.2 -1.0
Severe depression (siblings) 0.3 0.3 0.5 0.7 0.6 -0.2 0.6 0.7
Pack years adult smoking proportion 0.2 0.3 0.6 0.1 0.3 -0.8 0.6 0.6
Impedance of leg (right) 1.3 6.4 9.5 2.0 2.4 -3.1 2.5 2.5
Leg fat-free mass (left) 0.0 0.2 0.4 -0.1 0.1 -0.6 0.6 0.1
Trunk fat percentage 0.2 0.8 2.2 -1.5 -0.9 -0.2 -0.6 -0.7
Hand grip strength (right) 1.7 4.6 5.9 2.0 2.2 -1.6 2.4 2.3
Townsend deprivation index at recruitment 0.7 1.0 2.5 -0.4 -0.9 1.6 -0.8 -0.8
Current tobacco smoking 1.0 1.6 2.5 1.2 1.6 -1.0 1.2 1.3
Average weekly fortified wine intake 4.3 5.0 6.6 2.6 2.3 -2.1 2.3 1.9
Maternal smoking around birth 1.3 1.8 6.3 0.9 0.6 -2.5 1.0 0.8
Fed-up feelings 0.4 0.8 1.4 -0.6 -1.0 1.2 -0.6 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 -0.7 -0.4 0.1 -0.5 -0.5
Relative age voice broke 2.4 3.6 6.3 2.5 1.9 -1.7 1.8 1.5
Taking other prescription medications 2.2 3.5 6.2 -2.5 -1.7 1.2 -1.8 -1.8
Age when periods started (menarche) 1.5 3.7 5.2 1.8 1.8 -2.3 1.9 1.8
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.1 0.1 0.6 -0.2 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.7 1.3 0.5 0.2 0.5 0.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 1.6 -0.3 -0.0 -1.3 0.6 0.3
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -0.3 -0.6 1.0 -0.7 -0.8
Serious illness, injury or assault to yourself 1.5 1.9 2.9 -1.7 -1.2 0.9 -1.6 -1.3
High blood pressure 0.4 1.1 1.7 0.7 0.8 -1.1 1.3 1.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 1.4 1.2 0.7 -0.6 1.0 1.0
Multivitamins +/- minerals 2.5 3.2 3.7 1.6 1.6 -1.9 1.9 1.9
Stomach or abdominal pain in last month 0.1 0.2 0.5 0.7 -0.2 0.4 -0.0 -0.2
Supplements: Glucosamine 0.9 1.2 2.0 0.7 0.8 -1.1 1.4 1.4
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.7 -0.3 -0.4 0.8 -0.2 -0.4
Medication: Atenolol 0.2 0.2 0.7 0.5 -0.0 -0.8 0.4 0.3
Medication: Levothyroxine sodium 0.1 0.1 0.4 -0.3 0.7 0.0 -0.0 -0.0
Sitting height 1.2 8.4 15.9 2.5 2.6 -4.0 2.9 2.2
Chronic bronchitis/emphysema (father) 1.6 1.9 2.9 -1.7 -1.2 1.0 -1.4 -1.4
High blood pressure (mother) 5.7 8.0 9.1 -2.8 -3.0 2.8 -2.8 -2.7
Body mass index (BMI) 1.3 5.5 6.8 -2.6 -2.3 2.3 -2.2 -2.3
Impedance of leg (left) 1.5 7.1 8.8 2.2 2.8 -3.0 2.7 2.7
Leg predicted mass (left) 0.0 0.1 0.4 -0.2 0.1 -0.6 0.5 0.1
Trunk fat mass 0.1 0.6 1.8 -1.4 -0.7 -0.4 -0.3 -0.6
Waist circumference 0.0 0.1 0.2 -0.1 0.1 -0.3 0.4 0.2
Number of incorrect matches in round 2.8 4.7 5.8 -1.8 -2.2 2.2 -2.2 -2.4
Past tobacco smoking 0.0 0.1 0.3 0.5 0.0 -0.3 0.2 0.1
Alcohol usually taken with meals 0.1 0.2 1.1 -0.2 -1.0 0.1 -0.2 -0.2
Nervous feelings 1.4 2.7 3.8 1.9 1.3 -1.4 1.8 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.1 -1.0 -1.1 0.8 -1.1 -0.9
Hearing difficulty/problems with background noise 2.3 3.6 5.7 1.1 2.4 -1.8 2.0 2.0
Hair/balding pattern: Pattern 2 0.2 0.2 0.4 -0.5 0.6 -0.4 0.4 0.3
Had menopause 1.5 1.8 2.4 -0.9 -1.2 1.4 -1.5 -1.6
Had other major operations 0.1 0.1 0.2 -0.4 0.2 -0.4 -0.3 -0.4
Forced vital capacity (FVC) 0.1 0.5 0.8 0.7 0.9 -0.3 0.9 0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 6.1 2.5 1.7 -0.5 1.7 1.3
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.5 -0.4 -0.7 0.6 -0.4 -0.4
Qualifications: None of the above 0.6 1.2 2.5 -0.8 -1.0 1.6 -1.1 -0.9
Financial difficulties in last 2 years 4.0 5.4 9.9 -3.1 -2.3 1.4 -2.2 -2.2
Mouth/teeth dental problems 0.2 0.4 0.6 -0.6 -0.3 0.5 -0.8 -0.7
Heart attack 0.3 0.3 0.5 -0.5 -0.7 0.1 -0.7 -0.7
Allergy 0.0 0.1 0.2 -0.3 -0.5 -0.1 -0.4 -0.3
Pain all over the body in last month 1.2 1.3 2.4 -1.6 -1.0 0.6 -1.1 -1.3
Diabetes (self-reported) 1.2 1.9 2.6 1.6 1.6 -1.4 1.2 1.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.1 -0.2 -0.7 1.0 -0.7 -0.8
Medication: Ramipril 0.2 0.3 0.8 0.9 -0.5 -0.4 0.5 0.3
Medication: Simvastatin 0.1 0.1 0.2 0.2 0.4 -0.3 -0.1 0.2
Fluid intelligence score 4.3 9.0 11.6 3.0 2.4 -2.8 3.4 3.3
Illnesses of siblings 0.5 0.7 1.8 1.1 1.3 -0.4 0.5 0.5
Neuroticism score 0.2 0.4 0.8 0.3 0.1 -0.9 0.9 0.8
Weight 0.0 0.1 0.4 -0.6 -0.0 -0.5 0.2 -0.2
Impedance of arm (right) 0.5 2.3 6.0 1.4 0.7 -2.5 1.2 1.3
Arm fat percentage (right) 1.2 4.7 6.7 -2.6 -2.4 1.5 -2.1 -2.1
Trunk fat-free mass 0.4 2.5 3.8 1.0 1.8 -1.7 2.0 1.4
Hip circumference 0.3 1.1 1.4 -1.2 -1.1 1.1 -0.8 -1.1
Time employed in main current job 0.5 0.5 0.8 -0.5 -0.9 0.9 -0.7 -0.6
Alcohol intake versus 10 years previously 1.2 1.8 3.8 -1.6 -0.7 1.9 -1.1 -0.9
Father’s age at death 0.5 0.6 1.6 -1.3 -0.5 0.1 -0.8 -0.7
Worrier / anxious feelings 0.0 0.1 0.2 0.0 -0.2 -0.5 0.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.2 0.2 -0.4 0.4 0.3
Falls in the last year 0.1 0.1 0.3 0.3 -0.5 0.4 -0.1 -0.2
Hair/balding pattern: Pattern 3 0.0 0.1 0.2 -0.2 -0.5 0.1 -0.1 -0.1
Number of live births 0.9 1.3 1.8 -0.6 -1.4 1.2 -1.1 -1.3
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.1 0.4 0.1 0.3 0.2 0.1
Pulse rate 0.8 1.4 3.2 -1.8 -0.8 0.1 -1.2 -1.2
Happiness 0.2 0.2 0.4 -0.2 -0.6 0.6 -0.3 -0.3
Noisy workplace 0.8 0.9 3.1 -0.5 -0.8 1.8 -0.7 -0.5
Qualifications: A levels/AS levels or equivalent 4.3 9.4 10.6 3.2 2.9 -2.7 3.3 3.2
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.0 0.8 0.7 -0.5 1.0 0.9
Mouth/teeth dental problems: Dentures 0.3 0.4 1.5 -1.2 -0.3 0.7 -0.3 -0.2
Asthma 0.5 1.0 2.2 -1.5 -0.2 0.7 -0.9 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.4 -0.3 -0.0 -0.6 0.1 0.1
Medication: Cholesterol lowering 2.2 3.4 4.9 -2.2 -1.7 1.0 -2.2 -1.8
Depression (self-reported) 0.2 0.2 0.4 -0.2 0.4 -0.2 0.5 0.7
Medication: Lansoprazole 0.4 0.4 1.2 -0.3 1.1 -0.3 0.5 0.6
Prospective memory result 1.0 1.3 1.7 -0.9 -0.9 1.3 -1.3 -1.2
Lung cancer (father) 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.1
Illnesses of mother 1.3 1.6 2.8 1.1 1.7 -1.2 1.3 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.0 0.1 0.2 -0.1 -0.4 0.5 -0.0 -0.2
Pulse wave Arterial Stiffness index 0.6 0.7 1.3 -1.2 -0.8 0.6 -0.8 -0.8
Impedance of arm (left) 0.4 2.0 5.3 1.3 0.6 -2.3 1.1 1.2
Arm fat mass (right) 0.5 2.0 3.6 -1.9 -1.5 0.9 -1.2 -1.4
Trunk predicted mass 0.4 2.1 3.4 0.9 1.6 -1.6 1.8 1.2
Standing height 2.3 23.3 33.7 3.9 4.7 -5.8 5.2 4.3
Length of working week for main job 1.4 1.6 3.1 -1.8 -1.1 1.1 -1.1 -1.0
Exposure to tobacco smoke at home 3.8 4.3 5.8 -1.9 -2.4 1.6 -2.2 -2.1
Breastfed as a baby 0.7 0.9 1.5 0.5 1.2 -1.0 0.7 1.0
Tense / ‘highly strung’ 1.4 2.4 3.8 1.3 1.3 -1.9 1.6 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.0 1.8 0.7 1.4 -0.4 1.0 1.3
Hair/balding pattern: Pattern 4 2.7 6.6 11.0 -3.3 -2.5 1.8 -2.5 -2.6
Birth weight of first child 1.9 3.5 5.9 1.7 1.6 -2.4 1.8 1.8
Peak expiratory flow (PEF) 0.2 0.4 1.5 1.2 0.2 -0.3 0.3 0.1
Pulse wave reflection index 0.3 0.3 0.5 0.6 0.5 -0.7 0.4 0.5
Ever highly irritable/argumentative for 2 days 0.0 0.0 0.1 -0.1 -0.3 -0.0 -0.1 -0.1
Loud music exposure frequency 0.2 0.2 0.5 0.7 0.0 0.4 0.4 0.3
Qualifications: O levels/GCSEs or equivalent 2.1 3.3 6.1 2.5 1.1 -1.7 1.8 1.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.4 0.6 -0.3 -1.2 0.1 -0.0
Blood clot in the leg (DVT) 1.9 2.5 3.4 -1.7 -1.8 1.3 -1.5 -1.5
Medication: Paracetamol 0.1 0.2 0.7 -0.1 0.0 -0.9 0.0 -0.1
Headache pain in last month 0.0 0.0 0.1 -0.0 0.1 -0.4 0.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 1.4 1.2 0.3 0.5 0.1 -0.0
Glaucoma (self-reported) 0.1 0.1 0.1 -0.3 -0.2 -0.3 -0.3 -0.3
Gout (self-reported) 0.3 0.4 1.0 0.3 1.0 0.2 0.6 0.6
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.3 -0.2 0.1 0.6 -0.4 -0.5
Medication: Amlodipine 0.9 1.3 1.7 0.7 1.3 -1.3 1.1 1.1
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.4 -0.6 0.6 0.1 0.1 -0.0
Birth weight 1.5 3.3 5.2 1.8 2.3 -1.0 1.8 1.9
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.0 0.4 -0.5 0.4 0.4
High blood pressure (siblings) 0.7 1.0 1.5 -1.0 -1.2 0.9 -0.9 -0.9
Forced vital capacity (FVC), Best measure 0.0 0.1 0.2 0.2 0.1 -0.1 0.4 0.2
Body fat percentage 0.4 1.5 3.5 -1.9 -1.2 0.4 -1.0 -1.1
Leg fat percentage (right) 0.5 1.7 4.2 -2.0 -1.2 0.8 -1.1 -1.1
Arm fat-free mass (right) 0.4 2.0 3.1 0.7 1.7 -1.5 1.8 1.2
Exposure to tobacco smoke outside home 0.1 0.1 0.2 0.1 -0.5 0.2 -0.2 -0.3
Comparative body size at age 10 0.1 0.2 0.6 -0.4 -0.6 0.8 -0.1 -0.1
Number of full brothers 0.1 0.1 0.2 0.5 0.1 -0.3 -0.3 -0.3
Worry too long after embarrassment 2.1 3.6 4.7 1.1 2.0 -2.0 2.2 2.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.5 0.3 0.7 -0.0 0.6 0.7
Wheeze or whistling in the chest in last year 0.0 0.1 0.1 0.1 0.3 0.2 -0.2 -0.3
Number of children fathered 0.6 0.7 1.8 -1.3 -0.7 -0.0 -0.9 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 1.5 1.1 1.2 -0.2 0.9 0.8
Age at first live birth 0.7 1.2 1.9 1.0 1.0 -0.9 1.2 1.4
Pulse wave peak to peak time 0.9 1.1 1.7 1.3 0.9 -0.9 1.0 1.0
Health satisfaction 0.1 0.1 0.2 0.2 -0.1 -0.2 0.4 0.4
Shortness of breath walking on level ground 0.8 0.9 1.4 0.7 1.0 -0.6 1.2 1.2
Qualifications: College or University degree 1.4 4.4 6.2 2.2 1.6 -2.5 2.1 1.9
Eye problems/disorders: None of the above 1.4 1.6 3.6 -0.0 -1.3 1.9 -1.2 -1.2
Mouth/teeth dental problems: Loose teeth 1.5 1.8 3.4 -0.4 -1.1 1.8 -1.3 -1.6
Emphysema/chronic bronchitis 2.5 2.8 3.9 1.6 2.0 -1.6 1.6 1.6
Medication for pain relief, constipation, heartburn 0.6 1.0 1.9 1.1 1.4 -0.2 0.9 0.9
Neck or shoulder pain in last month 0.2 0.3 0.8 0.0 -0.5 0.9 -0.4 -0.5
Medication: Blood pressure 0.3 0.5 1.4 -0.7 0.2 -1.2 0.6 0.5
Angina (self-reported) 0.9 1.2 2.1 -1.4 -1.1 0.2 -1.2 -1.2
Migraine (self-reported) 0.5 0.7 1.7 -1.3 -0.8 0.5 -0.7 -0.6
Medication: Ibuprofen 0.4 0.5 1.2 -1.1 -0.7 -0.1 -0.6 -0.6
Medication: Allopurinol 0.7 0.9 1.9 1.1 1.4 -0.1 0.8 0.8
Medication: Omeprazole 1.1 1.3 2.4 -1.0 -1.6 0.9 -1.1 -1.2
Medication: Seretide 50 evohaler 0.0 0.1 0.2 -0.2 -0.0 -0.4 -0.2 0.0
Mean time to correctly identify matches 0.1 0.1 0.5 0.0 0.0 0.7 -0.2 -0.1
Heart disease (mother) 0.1 0.1 0.2 -0.0 -0.4 0.2 0.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.3 0.9 1.1 -0.9 0.7 0.8
Whole body fat mass 0.2 0.9 2.7 -1.6 -0.8 0.2 -0.6 -0.9
Leg fat mass (right) 0.3 1.0 3.0 -1.7 -0.9 0.3 -0.6 -0.8
Arm predicted mass (right) 0.3 1.6 2.6 0.5 1.6 -1.3 1.6 1.1
Pulse rate, automated reading 0.2 0.6 1.5 -0.3 0.9 -1.2 0.5 0.3
Alcohol intake frequency. 0.1 0.2 0.6 0.4 -0.5 0.7 -0.0 0.1
Comparative height size at age 10 1.6 8.6 14.4 2.1 2.7 -3.8 3.2 2.6
Number of full sisters 0.1 0.1 0.3 -0.3 0.5 0.1 0.1 0.3
Suffer from ‘nerves’ 0.1 0.2 0.6 -0.8 -0.2 0.3 -0.3 -0.3
Overall health rating 0.4 0.9 2.0 -0.4 -0.8 1.4 -0.9 -1.0
Chest pain or discomfort 1.0 1.5 2.2 1.5 1.3 -1.2 1.0 1.0
Had major operations 2.3 2.7 4.9 -1.3 -2.2 1.2 -1.6 -1.6
Age at last live birth 0.9 1.4 2.0 1.2 0.8 -1.1 1.3 1.4
Family relationship satisfaction 0.0 0.0 0.1 0.2 0.2 0.0 0.2 0.1
Leg pain on walking 0.4 0.5 0.9 -1.0 -0.9 0.5 -0.6 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.2 -0.8 -1.1 1.1 -0.5 -0.6
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.6 -0.6 -0.8 0.6 -0.6 -0.4
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.7 0.8 0.5 -0.7 0.6 0.5
Medication: Aspirin 0.5 0.6 1.3 -1.1 -0.9 -0.1 -0.7 -0.7
Supplements: Vitamin C 4.2 5.0 7.0 1.8 2.6 -2.1 2.3 2.3
Knee pain experienced in last month 0.3 0.4 1.1 0.2 0.8 -1.0 0.4 0.4
Hypertension (Self-reported) 0.5 1.4 2.1 0.9 1.0 -1.2 1.5 1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.1 -0.6 -1.0 0.7 -0.5 -0.6
Illnesses of father: Heart disease 0.0 0.0 0.2 0.4 -0.1 0.1 0.1 0.1
Illnesses of siblings: Diabetes 0.5 0.6 1.1 -1.1 -0.3 -0.0 -0.9 -0.9
Smoking status: Previous 0.3 0.4 0.8 -0.9 -0.4 0.6 -0.6 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.7 0.7 1.0 -1.3 1.0 0.7
Whole body fat-free mass 0.2 1.2 2.1 0.5 1.1 -1.2 1.4 0.9
Leg fat-free mass (right) 0.0 0.2 0.5 0.1 0.3 -0.7 0.7 0.3
Arm fat percentage (left) 1.1 4.4 6.2 -2.5 -2.3 1.5 -2.0 -2.0
Average weekly red wine intake 3.9 5.7 7.1 2.3 2.3 -2.3 2.7 2.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.2 -1.1 -0.7 0.1 -0.8 -0.5
Mood swings 0.1 0.2 0.4 -0.6 -0.3 0.4 -0.5 -0.6
Loneliness, isolation 0.0 0.1 0.1 -0.1 0.3 0.2 0.3 0.4
Long-standing illness, disability or infirmity 0.5 0.7 1.7 -1.3 -0.5 0.2 -1.0 -0.8
Ever had bowel cancer screening 0.6 0.7 1.5 -1.2 -0.4 0.1 -1.0 -0.8
Diabetes diagnosed by doctor 1.3 2.1 2.7 1.6 1.6 -1.6 1.2 1.2
Ever had stillbirth, spontaneous miscarriage or termination 2.8 2.9 4.8 1.7 2.2 -1.8 1.4 1.4
Friendships satisfaction 0.6 0.7 1.6 1.3 0.5 -0.0 0.9 0.8
Qualifications: nursing, teaching 0.3 0.5 1.1 1.0 0.4 -0.9 0.5 0.5
Commuting to job workplace: Walk 4.2 4.6 6.4 2.5 1.9 -1.8 2.2 2.1
Eye problems/disorders: Cataract 0.4 0.4 1.7 -0.5 0.4 -1.3 0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 6.8 10.8 13.7 3.7 2.9 -3.2 3.4 3.2
Medication for cholesterol 0.4 0.6 1.0 0.4 0.8 -1.0 0.8 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.3 1.6 2.6 -1.4 -1.6 -0.2 -1.4 -1.2
Back pain experienced in last month 1.0 1.4 3.7 -1.9 -0.7 1.1 -1.0 -0.9
Mineral and other dietary supplements 0.8 1.1 1.8 -0.9 -0.8 0.8 -1.3 -1.2
Breast cancer (self-reported) 1.2 1.4 2.0 0.8 1.2 -1.4 1.2 1.2
Asthma (self-reported) 0.3 0.7 2.0 -1.4 0.1 0.6 -0.7 -0.8
Osteoporosis (self-reported) 1.9 2.4 3.4 -1.3 -1.2 1.8 -1.7 -1.6
Osteoarthritis (self-reported) 0.1 0.1 0.3 -0.5 0.4 -0.1 0.3 0.4
Medication: Aspirin 1.2 1.6 3.0 -1.7 -1.4 0.2 -1.2 -1.2
Medication: Gliclazide 0.5 0.6 0.9 -1.0 -0.7 0.0 -0.8 -0.9
Illnesses of father: None of the above (group 1) 0.6 0.7 0.9 1.0 0.9 -0.3 1.0 0.9
Smoking status: Current 1.3 2.0 3.2 1.3 1.8 -1.2 1.4 1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.7 -0.4 -0.8 0.8 -0.7 -0.5
Whole body water mass 0.2 1.0 1.8 0.5 1.1 -1.1 1.4 0.8
Leg predicted mass (right) 0.0 0.2 0.4 0.0 0.3 -0.6 0.6 0.2
Arm fat mass (left) 0.7 3.0 4.8 -2.2 -1.8 1.2 -1.6 -1.7
Number of self-reported non-cancer illnesses 0.3 0.5 0.9 -0.7 -0.7 1.0 -0.6 -0.7
Average weekly champagne plus white wine intake 0.5 0.7 1.7 -1.3 -0.7 0.1 -0.8 -0.8
Miserableness 1.8 3.0 3.8 1.5 1.7 -1.5 2.0 2.0
Guilty feelings 0.1 0.1 0.3 0.5 0.5 0.2 0.4 0.2
Wears glasses or contact lenses 0.3 0.3 0.9 -0.0 0.9 -0.8 0.2 0.0
Ever taken oral contraceptive pill 0.4 0.4 1.2 -1.1 -0.4 -0.3 -0.6 -0.5
Hearing aid user 0.1 0.1 0.2 -0.4 -0.4 -0.0 -0.2 -0.0
Mother’s age at death 1.3 1.7 2.4 1.0 1.2 -1.2 1.5 1.4
Financial situation satisfaction 0.2 0.2 0.6 -0.8 -0.4 -0.4 -0.4 -0.4
Tinnitus: Yes, now most or all of the time 1.2 1.3 1.7 -1.1 -1.3 1.2 -1.2 -1.0
Commuting to job workplace: Public transport 2.4 2.8 3.8 1.6 1.5 -1.5 1.9 1.8
Eye problems/disorders: Glaucoma 0.3 0.4 0.9 -0.4 0.7 -1.0 0.4 0.4
Medication: Blood pressure 0.1 0.3 1.1 1.0 -0.1 0.1 0.4 0.1
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.1 -0.5 0.1 0.2 0.2
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 0.5 0.6 -0.4 1.0 0.9
High cholesterol (Self-reported) 0.0 0.0 0.0 0.0 -0.1 -0.0 -0.1 0.1
Medication: Bendroflumethiazide 0.1 0.1 0.2 -0.1 -0.3 0.5 -0.0 -0.3
Medication: Paracetamol 0.5 0.7 1.1 -0.9 -0.8 -0.0 -1.0 -1.1
Medication: Lisinopril 0.2 0.3 0.6 -0.5 -0.5 0.8 -0.2 -0.5
Medication: Atorvastatin 0.0 0.0 0.2 -0.4 -0.0 -0.1 -0.1 0.1
Illnesses of father: High blood pressure 0.4 0.5 1.2 -1.1 -0.8 0.2 -0.7 -0.5
Alcohol drinker status: Never 0.3 0.4 0.7 0.6 0.5 -0.5 0.8 0.8
Ever smoked 0.1 0.2 0.5 -0.5 -0.3 0.7 -0.5 -0.3
Basal metabolic rate 0.1 0.8 1.4 0.3 0.9 -1.0 1.2 0.7
Leg fat percentage (left) 0.4 1.5 3.4 -1.8 -1.1 1.0 -1.0 -1.1
Arm fat-free mass (left) 0.2 1.0 1.8 0.4 1.2 -1.1 1.4 0.8
Number of operations (self-reported) 0.3 0.5 1.2 -1.1 -0.3 0.1 -0.8 -0.7
Average weekly beer plus cider intake 0.9 1.3 1.8 -1.2 -0.4 1.3 -1.3 -1.1
Irritability 0.7 1.2 1.8 0.5 0.8 -1.3 1.2 1.3
Risk taking 0.2 0.3 0.5 -0.3 -0.5 0.3 -0.7 -0.7
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.5 -0.4 -1.2 0.4 -0.9 -1.0
Fractured/broken bones in last 5 years 0.0 0.0 0.1 -0.2 0.3 0.1 0.0 -0.0
Age started oral contraceptive pill 2.3 2.9 3.6 1.5 1.7 -1.9 1.7 1.7
Diastolic blood pressure, automated reading 0.2 0.6 1.7 -1.3 -0.6 -0.6 -0.5 -0.3
Ever depressed for a whole week 0.9 1.1 1.8 -1.0 -1.0 1.3 -0.9 -0.9
Unable to work because of sickness or disability 0.1 0.2 0.4 -0.6 0.5 0.1 0.3 0.4
Commuting to job workplace: Cycle 0.5 0.6 1.0 1.0 0.7 -0.7 0.9 0.8
Myopia 0.3 0.4 1.0 0.8 -0.0 -1.0 0.5 0.3
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.1 -0.3 -0.3 1.0 -0.9 -0.8
Cholesterol lowering medication 0.0 0.0 0.1 0.2 0.3 0.3 0.0 0.0
Medication: Omeprazole (e.g. Zanprol) 1.8 2.3 3.6 -1.6 -1.9 1.0 -1.5 -1.4
Pain experienced in last month 0.4 0.6 0.8 0.9 0.9 -0.9 0.7 0.6
Supplements: Calcium 0.7 0.8 2.5 0.6 0.7 -1.6 0.6 0.6
Basal cell carcinoma (self-reported) 0.1 0.1 0.3 -0.5 -0.2 -0.6 -0.1 -0.3
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.4 -0.6 -0.5 0.0 -0.6 -0.6
Deep venous thrombosis (DVT) (self-reported) 2.5 3.2 4.1 -2.0 -2.0 1.5 -1.7 -1.6
Heart disease (siblings) 0.2 0.2 0.5 -0.7 -0.6 0.1 -0.2 -0.2
Alcohol drinker status: Previous 0.1 0.2 0.3 0.1 -0.5 0.6 -0.3 -0.3
Pack years of smoking 0.4 0.6 0.8 0.5 0.6 -0.8 0.9 0.9
Impedance of whole body 1.0 5.1 8.8 2.0 1.9 -3.0 2.1 2.2
Leg fat mass (left) 0.3 1.1 2.9 -1.7 -0.9 0.5 -0.7 -0.9
Arm predicted mass (left) 0.2 1.2 2.2 0.5 1.2 -1.1 1.5 1.0