Hub : Genes

MAL2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0487	0.0189	0.00096	0.000	0.005	-0.001	0.003	0.001	3.8e-01	0.07400	0.42000	0.11	0.19000
2	TCGA	Lung Squamous Cell Carcinoma	0.0720	0.0342	0.00097	0.007	0.021	0.012	NA	0.030	4.4e-02	0.00160	0.01600	NA	0.00022
3	TCGA	Prostate Adenocarcinoma	0.0899	0.0406	0.00034	0.005	0.042	0.029	NA	0.012	8.8e-02	0.00003	0.00049	NA	0.01800
4	TCGA	Skin Cutaneous Melanoma	0.2600	0.1130	0.00900	-0.010	0.004	0.017	NA	-0.002	7.5e-01	0.25000	0.11000	NA	0.36000
5	TCGA	Thyroid Carcinoma	0.0850	0.0370	0.00098	0.040	0.015	0.022	NA	0.032	7.6e-05	0.01300	0.00300	NA	0.00039

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.2	1.9	3.6	-0.9	-1.7	1.0	-1.1	-1.9
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	-0.1	-0.6	0.8	-0.6	-1.2
Depressed Affect (Nagel 2018)	1.1	2.3	8.1	0.8	-2.9	0.0	0.8	-1.4
Depression (Nagel 2018)	1.1	1.6	4.4	-0.2	-2.1	1.0	1.0	-1.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	3.3	-0.1	1.8	-0.8	1.3	0.9
Neuroticism (Nagel 2018)	1.6	3.7	14.1	0.8	-3.8	1.0	0.0	-1.6
Schizophrenia (2018)	0.1	0.2	0.5	0.5	0.7	0.3	0.1	0.0
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	-0.3	0.2	-0.0	-0.3	0.7
Worry (Nagel 2018)	1.0	2.2	5.3	1.7	-2.3	0.6	-0.7	-1.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.5	-1.2	-0.9	-0.6	-1.1	0.0
Alzheimer’s Disease (in father)	1.2	1.3	2.4	1.5	-0.9	-1.6	-1.0	0.4
Alzheimer’s Disease (including proxy)	0.7	0.9	2.1	-0.3	-1.2	-1.0	-1.4	-0.0
Crohns Disease (2017)	0.6	1.4	3.9	-1.7	-0.1	2.0	0.4	0.1
Irritable Bowel Disease (IBD)	1.4	3.3	6.8	-2.5	-1.1	2.6	-0.9	-1.2
Ulcerative Colitis (UC)	1.9	3.5	6.3	-2.5	-1.7	2.0	-1.5	-1.5
Major Depression (MDD)	1.0	1.2	1.7	1.1	-1.2	1.1	-0.6	-1.3
Reaction Time	1.0	1.8	6.1	1.1	-2.5	0.1	-0.5	-1.2
Verbal and Numeric Reasoning (VNR)	1.0	2.4	5.8	0.5	2.4	-1.3	1.2	1.7
Breast Cancer	0.4	1.0	4.8	-2.2	-0.2	-0.1	-0.4	0.1
Ovarian Cancer	0.9	1.2	2.6	0.3	1.6	-1.5	-0.4	0.8
Prostate Cancer	0.9	1.3	4.0	0.6	1.1	-2.0	-0.5	0.9
Age at First Birth	0.5	0.7	1.4	-0.9	0.5	0.2	1.2	1.1
Bipolar Disorder (2011)	2.1	2.0	5.0	0.4	-2.1	0.8	-0.2	-2.2
Body Mass Index (BMI) (2010)	0.9	1.2	2.6	-1.3	0.6	-0.3	1.0	1.6
Coronary Artery Disease (CAD)	0.6	0.8	2.3	-0.2	1.5	-1.1	0.5	-0.0
Crohns Disease (2012)	0.5	0.9	3.9	-0.5	0.3	2.0	-0.2	-0.4
Mean Putamen Volume	0.8	1.0	3.1	-0.2	-1.8	1.0	-0.7	-0.3
Fasting Glucose	2.4	2.8	7.4	1.1	-2.3	0.1	-0.3	-2.7
HbA1C	0.6	0.6	1.4	0.7	-1.2	0.6	0.8	-0.5
HDL Cholesterol	1.1	1.8	5.9	1.2	-0.4	1.2	2.4	0.5
LDL Cholesterol	0.2	0.2	0.6	0.2	0.8	0.5	0.3	-0.5
Lupus	0.5	0.7	1.9	0.7	-0.0	1.4	-1.1	0.1
Neuroticism (2016)	0.2	0.3	0.7	0.9	-0.2	-0.6	0.1	-0.6
Primary Biliary Cirrhosis	0.6	0.8	1.8	-0.4	-1.4	-0.7	0.2	-1.3
Rheumatoid Arthritis	1.7	2.4	8.0	0.2	-1.4	-0.5	-2.8	-1.3
Schizophrenia (2014)	0.2	0.3	0.9	0.4	-0.5	0.6	0.1	-0.9
Triglycerides	0.4	0.6	1.4	-0.9	0.7	-0.4	1.2	0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.3	1.2	0.7	-0.1	0.8	0.1
Ulcerative Colitis	1.3	2.0	4.5	-0.7	0.4	2.0	-2.1	-0.7
Blood Eosinophil Count	0.8	5.8	25.4	1.6	0.2	-5.0	-0.9	-0.6
Blood Platelet Count	0.1	1.2	5.8	-2.4	0.5	0.0	0.3	0.0
Blood Red Count	0.3	3.3	11.0	1.1	3.3	0.3	0.6	1.9
Blood White Count	0.2	1.4	5.2	-2.3	0.9	-0.3	-0.0	1.0
Heel T-Score	1.7	13.3	44.9	-6.7	-2.4	-2.8	2.7	0.9
BMI	0.7	4.1	14.2	-1.0	3.8	-0.6	0.4	2.1
Height	0.3	5.7	16.2	0.9	2.3	1.7	1.8	4.0
Waist Hip Ratio (WHR)	0.1	0.5	1.7	-0.5	-0.2	-0.7	-1.3	-0.4
Systolic Blood Pressure	0.7	3.4	12.3	3.5	0.5	0.9	1.6	-0.9
Smoking Status	0.6	1.3	3.1	-1.3	0.3	1.2	1.8	0.5
Allergy or Eczema	0.1	0.3	0.7	0.5	0.9	0.5	0.2	0.5
Cardiovascular Disease	0.7	2.4	5.8	0.3	-2.0	1.1	2.4	-0.8
Hypothyroidism (self reported)	1.5	3.4	11.3	1.1	1.0	-1.9	-0.0	3.4
Respiratory disease	1.8	4.1	8.9	-2.0	-1.4	3.0	-1.5	-1.8
Type 2 Diabetes (T2D) (2018)	1.4	2.6	9.3	0.6	-3.0	-0.2	0.1	-1.8
Lung FEV1/FVC ratio	0.2	0.8	1.9	1.4	0.8	-1.0	-0.2	0.8
Lung FVC	0.5	2.5	4.5	-2.1	-2.0	1.8	0.7	-0.5
Neuroticism	0.9	2.2	8.0	0.8	-2.8	0.6	-0.7	-1.2
Chronotype (morning person)	0.6	1.5	2.7	1.6	-0.3	-1.6	1.3	0.5
Hair Pigment	0.0	1.1	3.8	-0.9	0.4	1.9	-0.7	-0.2
Tanning	0.1	1.8	6.4	-1.4	-0.7	-2.5	-0.2	0.2
Hand grip strength (left)	1.1	2.9	5.6	-0.2	2.0	-1.9	1.1	2.4
Number of treatments/medications taken	0.4	0.7	2.2	0.3	-1.5	0.4	-0.9	-0.7
Average weekly spirits intake	0.6	0.7	1.5	-0.1	-0.3	-1.2	-0.9	-1.0
Sensitivity / hurt feelings	0.5	0.8	2.9	0.6	-1.7	-0.6	0.7	-0.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.9	-0.8	-1.4	1.0	1.2	-0.5
Hearing difficulty/problems: Yes	1.7	2.6	9.9	-3.1	-0.4	1.7	0.3	0.3
Relative age of first facial hair	0.3	0.6	1.1	1.1	1.1	0.7	0.1	0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.9	-1.7	-1.1	-0.7	1.1	-0.0
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	0.9	0.5	-0.6	-0.4	0.1
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	-0.0	-1.2	-0.6	-0.5	-1.0
Systolic blood pressure, automated reading	0.9	2.6	10.5	3.2	1.3	-0.3	0.3	-0.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	6.7	-1.4	-2.6	-0.1	1.0	-1.1
Angina	0.8	1.0	3.6	-0.5	-1.9	0.8	0.1	-0.7
Medication for hormone replacement therapy	1.6	1.8	4.1	1.2	0.8	2.0	-1.4	1.0
Vitamin and mineral supplements	0.5	0.7	2.9	-0.6	1.7	0.1	0.6	0.3
Supplements: Zinc	0.8	0.9	1.9	-1.3	-1.4	0.6	0.5	-0.2
Medication: Co-codamol	0.3	0.3	0.8	0.7	0.0	0.6	-0.1	-0.9
Medication: Metformin	1.4	1.9	5.3	1.1	-2.3	-0.1	0.1	-1.8
Diabetes (father)	0.8	1.0	3.5	1.9	-0.3	-0.0	1.0	0.7
Diabetes (mother)	0.7	0.9	1.9	1.4	-0.8	1.4	-0.2	-0.4
Severe depression (siblings)	0.9	1.0	2.7	0.1	1.6	-0.4	-0.7	1.2
Pack years adult smoking proportion	1.2	1.9	5.2	0.6	-1.1	2.3	0.2	-1.6
Impedance of leg (right)	0.1	0.7	3.1	0.4	-1.8	-0.3	-0.3	-0.3
Leg fat-free mass (left)	1.1	5.8	15.3	-0.6	3.9	-0.2	1.0	3.5
Trunk fat percentage	0.1	0.4	1.0	0.2	0.8	-0.5	0.3	1.0
Hand grip strength (right)	1.1	3.0	4.8	-1.2	2.0	-1.3	1.8	2.2
Townsend deprivation index at recruitment	0.8	1.2	2.3	-1.0	-0.6	1.4	-1.5	-0.6
Current tobacco smoking	1.1	1.7	3.2	1.3	-1.7	0.9	0.4	-1.8
Average weekly fortified wine intake	1.4	1.6	4.7	1.1	1.5	-0.3	-2.2	-0.1
Maternal smoking around birth	1.3	1.8	3.1	-1.6	1.7	-0.7	0.3	1.8
Fed-up feelings	2.7	5.0	14.1	1.7	-3.7	0.5	0.4	-2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	7.3	-1.0	-2.7	1.2	1.1	-1.7
Relative age voice broke	0.2	0.3	0.8	0.0	-0.1	0.7	-0.9	-0.2
Taking other prescription medications	0.8	1.3	3.2	0.5	-1.8	1.4	-0.3	-0.8
Age when periods started (menarche)	0.3	0.8	1.9	-0.2	1.4	-0.9	-0.8	0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.7	0.9	-0.7	-0.2	-0.6	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.3	-2.7	-2.3	-1.1	0.8	-1.3
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.1	-0.7	-1.4	2.0	0.7	-0.2
Qualifications: CSEs or equivalent	0.4	0.6	2.4	-0.4	-1.5	-0.3	-0.4	0.1
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.9	-0.3	0.6	0.9	0.1
High blood pressure	0.4	1.2	3.2	1.2	-0.9	0.3	1.8	-0.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	-0.2	1.0	-0.1	0.7	1.3
Multivitamins +/- minerals	0.6	0.7	3.2	0.6	-1.8	0.1	-0.2	-0.3
Stomach or abdominal pain in last month	1.6	2.0	4.2	-1.0	-1.5	2.1	-1.4	-0.5
Supplements: Glucosamine	0.5	0.7	1.1	0.7	1.0	-0.5	-1.0	0.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	-1.2	0.9	0.3	0.3	0.6
Medication: Atenolol	0.4	0.5	1.3	1.1	0.8	-0.5	-0.3	0.4
Medication: Levothyroxine sodium	0.8	1.4	6.4	0.5	0.3	-0.6	0.1	2.5
Sitting height	0.7	4.7	11.6	0.4	1.5	-3.4	1.9	2.4
Chronic bronchitis/emphysema (father)	0.1	0.2	0.5	-0.4	-0.4	-0.2	0.0	-0.7
High blood pressure (mother)	0.5	0.6	1.7	1.3	0.3	-0.8	0.6	-0.6
Body mass index (BMI)	0.4	1.7	5.4	-0.3	2.3	-0.7	0.2	1.6
Impedance of leg (left)	0.3	1.6	6.9	0.7	-2.6	-0.2	0.2	-0.8
Leg predicted mass (left)	1.1	5.9	15.4	-0.6	3.9	-0.2	1.0	3.5
Trunk fat mass	0.4	1.6	3.9	-0.2	2.0	-0.5	0.4	1.9
Waist circumference	0.9	3.3	11.1	-0.2	3.3	-0.6	0.8	2.1
Number of incorrect matches in round	0.9	1.5	3.6	-0.4	-1.9	-0.2	0.1	-1.9
Past tobacco smoking	1.9	3.6	4.2	2.0	-1.4	-1.9	-2.0	-2.0
Alcohol usually taken with meals	1.0	1.7	4.9	-2.2	0.6	-1.2	0.5	1.3
Nervous feelings	0.4	0.7	2.2	0.1	-0.3	1.5	-0.8	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	5.5	-0.3	-0.6	0.6	2.3	0.5
Hearing difficulty/problems with background noise	0.8	1.3	5.9	-2.4	-0.4	0.4	0.0	0.5
Hair/balding pattern: Pattern 2	2.6	3.3	13.4	-1.3	-0.1	3.7	-0.5	-1.1
Had menopause	1.0	1.3	2.3	1.5	1.1	-0.7	-1.3	-0.9
Had other major operations	0.5	0.6	1.2	0.4	0.4	-0.9	-1.1	-0.9
Forced vital capacity (FVC)	0.8	3.1	6.0	-1.6	0.1	2.5	2.1	1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	6.0	-2.5	-1.9	-1.7	1.4	-0.4
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	5.7	-2.4	1.4	0.6	0.4	2.1
Qualifications: None of the above	1.6	3.5	8.3	0.3	-2.9	0.8	-0.1	-2.9
Financial difficulties in last 2 years	0.4	0.6	2.0	-0.3	-0.4	1.4	-0.1	-0.8
Mouth/teeth dental problems	0.4	0.7	1.5	0.0	-0.2	-1.1	1.2	0.7
Heart attack	1.2	1.5	4.2	-0.1	-2.0	1.3	0.8	-1.0
Allergy	0.3	0.7	1.3	0.4	0.1	-1.1	-1.1	-0.9
Pain all over the body in last month	0.5	0.5	2.2	-0.5	-1.5	-0.1	0.2	-0.3
Diabetes (self-reported)	2.4	3.7	10.0	1.8	-3.2	1.1	0.6	-2.0
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.4	0.9	-0.3	0.5	0.9
Medication: Ramipril	0.6	0.7	3.0	0.3	-1.7	-0.3	-0.2	-0.5
Medication: Simvastatin	0.4	0.6	1.5	1.1	-1.2	-0.2	-0.2	-0.3
Fluid intelligence score	0.6	1.3	3.3	1.4	1.8	-0.5	0.8	0.7
Illnesses of siblings	1.2	1.7	4.9	-2.2	0.8	-1.1	0.4	1.2
Neuroticism score	0.7	1.4	5.8	0.3	-2.4	0.7	0.0	-0.7
Weight	1.1	5.3	14.4	-0.3	3.8	-0.7	0.9	3.3
Impedance of arm (right)	0.5	2.3	7.5	1.1	-2.7	1.1	0.4	-1.1
Arm fat percentage (right)	0.1	0.3	0.7	-0.0	0.8	-0.6	-0.3	0.6
Trunk fat-free mass	1.4	8.0	20.8	-0.8	4.6	-0.9	0.8	4.1
Hip circumference	1.1	4.6	10.1	-0.9	3.2	-0.4	1.8	2.9
Time employed in main current job	0.6	0.7	1.9	-0.2	-0.8	-0.8	-1.4	-0.6
Alcohol intake versus 10 years previously	0.5	0.8	2.2	-0.7	-1.5	0.6	-0.1	-1.0
Father’s age at death	0.6	0.9	1.9	0.7	1.4	1.3	-0.5	0.3
Worrier / anxious feelings	0.9	1.7	2.7	1.5	-1.6	-0.1	-1.4	-1.3
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.1	-0.4	-1.7	2.5	-0.8	-1.3
Falls in the last year	0.5	0.7	2.0	-0.7	-0.2	0.8	0.5	-1.4
Hair/balding pattern: Pattern 3	0.4	0.5	1.4	1.2	-0.5	-0.5	0.3	-0.9
Number of live births	0.7	1.0	3.5	-1.0	0.0	-1.9	-0.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	3.9	-1.9	-0.4	1.7	2.0	0.9
Pulse rate	0.5	0.8	1.1	0.4	0.9	-0.8	-1.0	1.0
Happiness	0.3	0.4	1.3	-1.1	-0.1	-0.0	-0.3	0.8
Noisy workplace	0.3	0.3	0.6	-0.6	-0.8	-0.5	-0.2	-0.6
Qualifications: A levels/AS levels or equivalent	2.3	5.0	12.7	-1.7	3.6	0.9	0.1	2.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.3	-0.8	0.4	0.9	0.5	1.1
Mouth/teeth dental problems: Dentures	0.4	0.7	1.2	0.7	-0.6	0.1	-1.1	-1.1
Asthma	1.3	2.5	8.4	-1.2	-1.5	2.9	-0.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.0	-1.2	0.6	-1.4	-1.0	1.2
Medication: Cholesterol lowering	0.8	1.3	3.5	0.2	-1.9	1.5	-0.2	-0.9
Depression (self-reported)	1.9	2.3	5.1	0.6	-2.2	1.6	-0.9	-1.6
Medication: Lansoprazole	1.0	1.2	3.4	-0.9	-0.5	0.8	-1.9	-0.8
Prospective memory result	0.2	0.2	0.5	0.3	-0.5	0.7	0.4	0.0
Lung cancer (father)	0.6	0.7	2.5	0.2	-1.6	0.4	-0.5	-0.6
Illnesses of mother	1.8	2.3	4.9	-2.2	0.8	0.9	0.6	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	4.2	-0.5	-0.6	2.0	2.1	0.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-1.1	0.3	1.2	-0.2	0.3
Impedance of arm (left)	0.7	3.1	10.2	0.6	-3.2	1.3	0.7	-1.6
Arm fat mass (right)	0.4	1.7	4.5	-0.2	2.1	-0.8	0.1	1.7
Trunk predicted mass	1.3	7.7	20.9	-0.7	4.6	-0.9	0.7	4.0
Standing height	0.7	6.8	19.1	-0.0	3.6	-0.3	1.5	4.4
Length of working week for main job	0.7	0.8	3.0	1.7	0.1	-0.0	-0.9	-0.3
Exposure to tobacco smoke at home	1.0	1.1	1.9	1.1	-0.1	1.1	-1.1	-1.4
Breastfed as a baby	0.6	0.8	1.7	-0.9	-0.9	0.7	1.3	-0.1
Tense / ‘highly strung’	0.3	0.5	1.2	0.3	0.5	-0.3	-0.8	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.9	1.0	-0.2	-0.5	1.1
Hair/balding pattern: Pattern 4	0.5	1.2	4.9	-0.3	-0.5	-2.2	0.8	0.1
Birth weight of first child	0.9	1.7	5.4	0.1	1.7	0.4	0.2	2.3
Peak expiratory flow (PEF)	0.5	1.1	4.7	-2.2	-0.3	0.1	0.9	0.3
Pulse wave reflection index	0.6	0.7	1.9	-0.2	-1.4	1.1	0.1	-0.5
Ever highly irritable/argumentative for 2 days	0.3	0.3	1.3	-0.1	0.4	-0.2	-1.1	0.4
Loud music exposure frequency	0.9	1.0	3.8	-0.4	-0.5	0.6	1.9	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.7	0.1	1.2	-0.0	0.0	1.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.7	-1.2	1.6	0.7	-0.9	0.9
Blood clot in the leg (DVT)	1.1	1.4	5.0	1.3	-0.1	0.1	2.2	0.7
Medication: Paracetamol	1.0	1.6	4.2	-1.6	-0.9	-0.5	2.0	0.3
Headache pain in last month	0.2	0.3	1.0	-1.0	-0.2	-0.5	0.1	-0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.9	-0.5	1.4	-0.6	1.3	0.9
Glaucoma (self-reported)	0.5	0.6	1.5	-0.0	-0.9	-0.7	1.2	-0.6
Gout (self-reported)	1.1	1.5	4.5	-0.4	1.4	-0.8	0.3	2.1
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	5.2	0.2	-0.0	-1.6	0.0	2.3
Medication: Amlodipine	0.4	0.6	1.0	0.6	-0.6	1.0	0.9	-0.4
Medication: Ventolin 100micrograms inhaler	1.3	1.7	3.2	0.5	-1.2	1.8	-1.2	-1.5
Birth weight	0.4	0.8	1.6	1.3	-0.2	-1.1	-0.8	0.7
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.6	1.1	-0.9	-0.1	-0.7	-1.3
High blood pressure (siblings)	0.8	1.1	2.7	1.2	-0.9	1.6	0.2	-0.7
Forced vital capacity (FVC), Best measure	0.8	2.8	6.9	-0.5	-0.8	2.6	2.3	0.9
Body fat percentage	0.1	0.5	1.2	-0.2	1.0	-0.6	-0.1	1.1
Leg fat percentage (right)	0.4	1.3	3.4	-0.4	1.8	-0.7	-0.5	1.4
Arm fat-free mass (right)	1.2	5.9	16.0	-0.9	4.0	-1.2	0.5	3.4
Exposure to tobacco smoke outside home	0.9	1.2	2.9	-0.4	-0.8	1.7	-0.2	-1.6
Comparative body size at age 10	0.6	1.6	5.3	-0.3	2.3	-0.6	0.3	1.5
Number of full brothers	0.5	0.6	2.1	-1.4	-0.5	-0.6	-0.3	0.5
Worry too long after embarrassment	0.8	1.4	2.7	-0.5	-1.5	1.6	-1.3	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.2	-1.2	-0.6	2.3	1.3	-0.2
Wheeze or whistling in the chest in last year	2.1	3.7	11.0	-1.2	-1.9	3.3	1.4	-0.5
Number of children fathered	0.5	0.5	2.1	0.1	1.5	0.3	0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.8	3.2	6.1	1.2	-2.5	2.1	0.4	-2.0
Age at first live birth	1.2	2.2	7.2	-0.2	2.7	0.1	0.2	1.9
Pulse wave peak to peak time	0.4	0.5	1.3	1.1	0.0	-1.2	0.3	0.0
Health satisfaction	0.4	0.6	2.4	0.1	-0.6	1.6	0.1	0.1
Shortness of breath walking on level ground	1.9	2.2	6.4	0.6	-0.8	2.5	1.5	-1.2
Qualifications: College or University degree	1.7	5.2	19.8	-0.7	4.5	-0.3	-0.3	2.3
Eye problems/disorders: None of the above	2.7	3.2	7.1	-0.7	2.3	0.7	-1.5	2.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	-0.7	0.1	-0.0	0.4	-0.9
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.6	-0.4	0.4	0.1	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.1	1.2	0.8	-0.4	-1.4	-0.3
Neck or shoulder pain in last month	0.3	0.4	1.7	-0.2	-0.3	-0.6	-0.0	-1.3
Medication: Blood pressure	0.5	0.9	1.9	0.0	-1.4	-0.3	-1.1	-1.2
Angina (self-reported)	0.9	1.1	4.0	-0.4	-2.0	1.0	0.3	-0.7
Migraine (self-reported)	1.1	1.3	3.3	0.2	-1.8	0.1	-0.2	-1.8
Medication: Ibuprofen	0.8	0.9	2.3	-0.5	0.4	-1.5	-0.8	1.2
Medication: Allopurinol	1.3	1.7	4.1	-0.4	1.3	-1.6	-0.2	2.0
Medication: Omeprazole	0.8	1.0	2.4	-1.3	-0.2	1.6	0.6	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.5	-0.6	0.2	0.7	-0.0	-0.1
Mean time to correctly identify matches	0.6	1.1	2.2	1.1	-1.5	0.3	-1.3	-0.5
Heart disease (mother)	1.1	1.4	2.8	1.2	-1.2	0.2	-1.0	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	-0.7	-0.8	0.3	1.2	-0.4
Whole body fat mass	0.4	1.8	4.5	-0.4	2.1	-0.6	0.3	1.9
Leg fat mass (right)	0.7	2.8	7.6	-0.6	2.7	-0.5	0.1	2.4
Arm predicted mass (right)	1.2	6.1	14.9	-1.1	3.9	-1.3	0.8	3.5
Pulse rate, automated reading	0.1	0.5	0.9	-1.0	-0.1	-0.6	0.8	0.7
Alcohol intake frequency.	0.1	0.2	0.4	0.6	-0.5	-0.3	0.5	-0.2
Comparative height size at age 10	0.8	4.7	14.9	-0.2	2.5	0.6	1.2	3.9
Number of full sisters	2.0	2.4	11.2	-0.2	-0.2	3.3	-0.1	-0.9
Suffer from ‘nerves’	0.6	0.9	1.9	1.4	-0.3	1.4	-0.3	-0.8
Overall health rating	2.2	4.8	14.1	0.7	-3.8	1.7	-0.6	-2.5
Chest pain or discomfort	0.5	0.7	2.0	-0.2	-1.2	0.0	-1.4	0.5
Had major operations	0.6	0.7	1.9	-1.4	-0.2	1.1	-0.0	0.3
Age at last live birth	0.5	0.7	1.4	0.8	1.0	0.0	0.5	1.2
Family relationship satisfaction	1.4	1.8	5.8	-2.4	1.1	0.3	1.3	0.3
Leg pain on walking	0.3	0.4	0.9	0.2	-0.4	1.0	0.7	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.6	2.0	4.0	-0.7	-2.0	1.2	2.0	-0.2
Commuting to job workplace: Car/motor vehicle	1.2	1.4	3.6	1.1	-1.2	0.2	-1.9	-0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.3	0.4	0.2	-1.5	1.1	-0.5
Medication: Aspirin	0.6	0.7	1.1	1.0	0.7	1.0	0.7	0.8
Supplements: Vitamin C	1.1	1.3	5.3	0.4	-2.3	0.0	-0.5	-0.9
Knee pain experienced in last month	1.1	1.7	3.4	0.8	-1.0	-1.4	-1.1	-1.9
Hypertension (Self-reported)	0.4	1.2	3.2	1.4	-0.7	0.3	1.8	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.1	-0.5	0.2	1.4	-0.4	0.5
Illnesses of father: Heart disease	0.7	1.0	3.0	0.2	-0.0	0.7	-1.2	-1.7
Illnesses of siblings: Diabetes	0.7	0.8	1.6	0.8	-1.3	-0.0	1.1	-0.8
Smoking status: Previous	2.8	4.2	6.4	-2.3	1.4	1.9	2.5	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	9.7	-0.3	0.0	-0.1	3.1	1.8
Whole body fat-free mass	1.3	7.3	19.5	-0.6	4.4	-0.7	0.9	3.9
Leg fat-free mass (right)	0.9	5.0	12.2	-0.5	3.5	0.0	1.3	3.3
Arm fat percentage (left)	0.1	0.2	0.4	-0.6	0.6	-0.5	0.0	0.4
Average weekly red wine intake	1.4	2.0	3.8	-1.8	1.6	0.3	0.7	2.0
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	0.7	-0.7	0.5	-0.1	0.2
Mood swings	1.1	1.9	5.1	-0.4	-2.3	-0.4	2.0	-0.3
Loneliness, isolation	1.7	2.4	7.6	-0.7	-2.8	1.0	1.4	-0.9
Long-standing illness, disability or infirmity	0.8	1.2	2.5	-0.3	-1.2	1.3	-0.7	-1.6
Ever had bowel cancer screening	0.8	0.9	3.4	-1.9	0.1	-0.2	0.9	0.5
Diabetes diagnosed by doctor	2.1	3.5	9.5	1.7	-3.1	0.2	0.2	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.6	-1.0	1.1	-0.4	0.9	1.9
Friendships satisfaction	0.7	0.8	1.6	-1.2	-1.3	-0.2	1.1	0.0
Qualifications: nursing, teaching	0.7	1.1	4.2	0.6	2.1	-0.5	0.6	0.5
Commuting to job workplace: Walk	2.3	2.5	4.1	-0.1	1.4	-1.6	2.0	1.9
Eye problems/disorders: Cataract	0.5	0.6	1.8	0.5	-0.3	-0.7	1.3	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.7	-1.3	-0.9	0.8	-0.5	-1.1
Medication for cholesterol	0.7	1.0	2.3	-1.2	0.6	-1.5	-1.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.8	2.1	-1.5	-0.8	-0.1	-0.1	1.0
Back pain experienced in last month	0.3	0.4	1.0	0.4	-0.9	0.3	-0.3	-1.0
Mineral and other dietary supplements	0.1	0.2	0.8	-0.2	-0.1	-0.1	0.9	-0.1
Breast cancer (self-reported)	0.9	1.1	5.0	2.2	-0.1	-0.1	-0.0	-0.6
Asthma (self-reported)	1.6	3.2	12.1	-1.3	-1.4	3.5	0.3	-0.4
Osteoporosis (self-reported)	1.0	1.3	1.9	1.0	1.4	-1.2	-1.3	0.4
Osteoarthritis (self-reported)	2.9	3.8	6.6	2.6	-1.2	2.0	-2.0	-1.7
Medication: Aspirin	0.7	0.9	1.6	1.0	0.5	1.2	1.2	0.4
Medication: Gliclazide	0.7	0.8	1.4	1.1	-1.2	-0.7	-0.9	-0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	-1.2	0.0	0.8	0.5	1.1
Smoking status: Current	0.8	1.3	2.4	1.4	-1.3	0.5	-0.1	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	4.5	-0.5	-0.8	2.1	0.0	0.1
Whole body water mass	1.3	7.3	20.0	-0.6	4.5	-0.6	0.9	3.8
Leg predicted mass (right)	1.0	5.2	12.5	-0.6	3.5	-0.1	1.4	3.4
Arm fat mass (left)	0.4	1.5	4.2	-0.5	2.1	-0.6	0.5	1.6
Number of self-reported non-cancer illnesses	1.3	2.3	4.4	0.4	-1.9	2.1	0.7	-1.7
Average weekly champagne plus white wine intake	0.8	1.1	2.6	-0.1	1.6	-0.7	0.5	1.6
Miserableness	1.0	1.7	5.0	-1.1	-2.2	-0.6	0.2	-1.4
Guilty feelings	0.4	0.6	2.7	0.2	-1.6	0.3	0.6	-0.1
Wears glasses or contact lenses	0.4	0.5	1.1	1.0	-0.3	0.3	-0.2	-1.0
Ever taken oral contraceptive pill	1.1	1.2	2.5	-1.1	0.4	-0.5	1.6	1.4
Hearing aid user	2.7	3.1	11.8	-0.4	0.4	3.4	1.8	0.1
Mother’s age at death	0.7	0.9	2.9	0.8	0.2	-0.1	-1.7	-0.9
Financial situation satisfaction	0.4	0.4	0.6	-0.7	-0.2	0.7	0.8	0.7
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.2	-0.1	-1.1	0.2	1.2	-1.5
Commuting to job workplace: Public transport	0.6	0.8	2.1	-0.1	0.0	1.4	1.3	-0.2
Eye problems/disorders: Glaucoma	0.9	1.0	2.2	0.8	-1.4	-1.5	0.4	-0.6
Medication: Blood pressure	0.9	1.8	7.0	1.1	0.3	0.9	2.6	-0.2
Pain type(s) experienced in last month: Hip pain	1.8	2.2	5.1	-2.3	0.6	2.0	1.3	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.3	0.5	-0.0	-0.1	-0.2
High cholesterol (Self-reported)	0.4	0.7	2.0	-0.8	-0.1	1.4	1.0	0.1
Medication: Bendroflumethiazide	0.2	0.3	1.2	0.5	0.5	-1.1	-0.2	-0.0
Medication: Paracetamol	0.5	0.8	1.8	-1.4	-1.2	-0.2	1.0	0.1
Medication: Lisinopril	0.6	0.8	2.9	-0.7	-0.6	-0.0	-1.7	-0.5
Medication: Atorvastatin	1.1	1.4	4.7	-1.4	-0.1	2.2	-0.0	-0.4
Illnesses of father: High blood pressure	0.5	0.7	1.5	0.1	1.0	-0.7	-1.2	0.6
Alcohol drinker status: Never	0.6	0.8	2.4	0.4	-0.7	0.8	0.2	-1.6
Ever smoked	0.8	1.4	2.8	-1.7	0.3	1.6	1.1	0.7
Basal metabolic rate	1.2	6.8	18.1	-0.5	4.3	-0.5	1.0	3.8
Leg fat percentage (left)	0.2	0.7	2.0	-0.0	1.4	-0.6	-0.0	1.2
Arm fat-free mass (left)	1.3	6.4	19.1	-0.3	4.4	-1.0	0.6	3.4
Number of operations (self-reported)	1.2	1.7	5.7	-0.2	-1.4	0.2	-1.0	-2.4
Average weekly beer plus cider intake	4.5	6.5	11.5	1.0	-3.4	2.8	1.2	-3.3
Irritability	0.7	1.1	2.1	-1.4	-1.3	1.3	-0.5	0.1
Risk taking	0.3	0.5	1.3	-1.1	0.2	-0.1	0.4	1.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.4	-1.2	0.5	0.1	0.7	0.2
Fractured/broken bones in last 5 years	1.7	2.1	4.2	-0.3	2.1	-1.1	1.7	1.5
Age started oral contraceptive pill	0.8	0.9	2.1	0.9	-0.1	-1.5	-1.3	-0.3
Diastolic blood pressure, automated reading	0.3	0.9	3.4	0.1	1.8	-0.5	-0.3	1.0
Ever depressed for a whole week	0.6	0.7	1.1	-1.0	1.0	-0.1	-1.1	0.7
Unable to work because of sickness or disability	0.4	0.5	1.7	0.5	-1.3	0.3	-0.2	-0.7
Commuting to job workplace: Cycle	0.5	0.6	2.0	-0.3	-0.4	0.4	1.4	-0.6
Myopia	0.4	0.6	2.4	0.2	0.0	1.6	-0.8	0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	3.6	-0.7	1.1	-0.4	-1.9	0.3
Cholesterol lowering medication	0.5	0.8	2.3	0.1	-0.3	1.0	1.5	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.4	1.6	3.2	-1.3	-1.3	1.8	1.3	-0.2
Pain experienced in last month	0.5	0.8	2.7	0.7	0.4	-0.2	0.6	1.7
Supplements: Calcium	1.8	1.9	3.3	-1.8	1.2	-1.1	-1.1	1.6
Basal cell carcinoma (self-reported)	1.3	1.5	6.6	-2.6	-0.1	0.4	-1.0	-0.2
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.7	-0.3	-2.2	1.5	0.5	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.3	1.2	-0.1	0.1	2.3	0.6
Heart disease (siblings)	0.5	0.6	1.3	-0.4	-0.8	-1.2	-0.5	-0.8
Alcohol drinker status: Previous	1.0	1.1	2.6	1.6	-1.2	-0.6	0.5	-1.1
Pack years of smoking	0.9	1.3	3.5	0.6	-0.9	1.9	0.2	-1.4
Impedance of whole body	0.6	3.3	11.6	1.1	-3.4	0.5	0.4	-1.8
Leg fat mass (left)	0.6	2.3	6.3	-0.3	2.5	-0.6	0.2	2.2
Arm predicted mass (left)	1.2	6.1	18.3	-0.0	4.3	-1.2	0.4	3.2