Hub : Genes

MAN1A2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.2230	0.0510	3.3e-06	0.108	NA	0.143	NA	0.154	1.8e-08	NA	6.8e-11	NA	1.2e-11
2	GTEx	Muscle Skeletal	0.0647	0.0268	8.9e-03	0.072	NA	0.065	NA	0.067	1.5e-07	NA	5.5e-07	NA	3.9e-07
3	GTEx	Pancreas	0.1810	0.0640	4.4e-03	0.004	NA	-0.007	NA	0.001	2.1e-01	NA	8.5e-01	NA	2.7e-01
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1490	0.0450	6.6e-04	0.158	NA	0.147	NA	0.152	5.5e-09	NA	1.9e-08	NA	1.1e-08
5	GTEx	Skin Sun Exposed Lower leg	0.1480	0.0390	1.9e-05	0.077	NA	0.095	NA	0.085	6.4e-07	NA	3.0e-08	NA	1.5e-07
6	METSIM	Adipose	0.0398	0.0177	8.3e-03	0.004	0.009	-0.002	0.009	0.001	7.1e-02	0.0140	8.7e-01	0.0120	1.8e-01
7	YFS	Blood	0.0247	0.0099	1.4e-03	0.018	0.007	0.009	0.007	0.012	9.0e-07	0.0022	3.5e-04	0.0024	7.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.1	1.8	3.5	-1.6	1.3	-0.2	1.7	1.2	-1.9	0.7
Bipolar Disorder or Schizophrenia	0.5	1.3	3.5	-0.1	1.3	0.2	0.8	0.9	-1.7	1.9
Depressed Affect (Nagel 2018)	1.4	2.9	6.8	-1.5	-1.3	-1.8	1.6	1.6	-2.6	-1.0
Depression (Nagel 2018)	2.0	3.0	7.0	-1.4	-0.8	-1.7	2.2	2.7	-1.9	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.9	8.2	0.7	0.7	1.2	-0.9	-1.2	2.9	0.2
Neuroticism (Nagel 2018)	3.1	7.4	15.5	-3.2	0.6	-2.2	3.0	2.9	-3.9	1.8
Schizophrenia (2018)	0.4	0.8	3.3	1.2	0.5	0.5	-0.3	0.2	-0.6	1.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	0.0	-0.2	-1.3	-0.4	-0.9	-0.6	0.2
Worry (Nagel 2018)	7.7	16.2	27.4	-4.9	2.8	-2.0	4.1	3.5	-5.2	4.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.8	-0.0	0.2	0.8	0.4	0.9	0.1	0.1
Alzheimer’s Disease (in father)	0.2	0.3	1.0	-0.3	0.1	0.4	0.1	-0.2	-1.0	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	-0.3	0.3	0.6	0.2	0.4	-0.2	-0.4
Crohns Disease (2017)	0.3	0.7	2.0	-1.0	1.4	-0.2	1.1	0.7	-0.3	0.4
Irritable Bowel Disease (IBD)	0.2	0.5	2.1	0.3	0.5	0.2	0.3	0.2	0.9	-1.5
Ulcerative Colitis (UC)	1.0	1.9	8.5	1.4	-0.9	0.4	-0.4	0.1	1.3	-2.9
Major Depression (MDD)	2.9	3.6	6.9	-2.2	1.0	0.2	2.3	2.6	-2.6	0.5
Reaction Time	0.3	0.6	1.7	-0.7	1.3	0.5	0.4	0.2	-1.0	0.5
Verbal and Numeric Reasoning (VNR)	0.6	1.4	6.9	0.1	1.0	1.3	-0.3	-0.6	2.6	0.4
Breast Cancer	0.5	1.2	2.9	0.2	0.5	0.1	-1.1	-1.7	-1.5	1.3
Ovarian Cancer	0.5	0.6	1.8	-1.3	1.1	0.8	0.7	0.2	0.3	0.6
Prostate Cancer	2.2	3.1	5.7	-2.1	2.1	0.9	2.4	1.9	-1.8	-0.1
Age at First Birth	1.8	2.7	9.5	1.1	0.1	1.2	-1.5	-2.0	3.1	0.3
Bipolar Disorder (2011)	1.1	1.0	3.0	-0.2	1.0	1.1	0.3	0.2	-1.7	1.4
Body Mass Index (BMI) (2010)	1.0	1.4	2.8	-1.0	1.4	1.1	1.6	1.7	-0.4	0.6
Coronary Artery Disease (CAD)	3.1	3.8	7.0	-1.9	2.3	0.8	2.6	2.2	-1.7	1.4
Crohns Disease (2012)	0.5	0.8	2.4	-0.9	1.6	0.5	1.1	0.7	0.3	0.5
Mean Putamen Volume	0.7	0.8	2.7	-0.6	0.8	1.2	0.3	0.1	1.7	-0.7
Fasting Glucose	1.0	1.2	6.3	0.5	-0.7	-1.0	-0.2	0.3	-2.5	-0.5
HbA1C	1.5	1.6	4.7	-1.0	1.3	1.0	1.3	1.1	-2.2	-0.0
HDL Cholesterol	5.0	8.4	12.8	3.4	-3.6	-1.6	-3.5	-2.9	2.7	-2.1
LDL Cholesterol	1.8	2.8	6.8	-1.5	2.1	0.5	1.5	1.0	-1.6	2.6
Lupus	0.9	1.3	2.4	-1.5	0.4	-1.0	1.2	1.2	-1.5	0.7
Neuroticism (2016)	4.7	6.8	12.1	-3.1	1.1	-1.0	3.3	3.2	-3.5	1.6
Primary Biliary Cirrhosis	1.8	2.5	6.2	2.0	-2.3	-0.6	-1.2	-0.5	-0.1	-2.5
Rheumatoid Arthritis	1.1	1.5	4.1	-0.7	0.9	1.9	1.0	0.9	2.0	0.1
Schizophrenia (2014)	0.5	1.1	4.0	-0.2	0.9	-0.7	0.7	0.7	-2.0	1.2
Triglycerides	1.9	3.1	7.1	-1.3	1.9	1.9	1.7	1.6	-2.7	0.4
Type 2 Diabetes (T2D) (2012)	1.4	1.6	6.8	-1.5	1.1	-0.3	0.9	0.2	-2.6	0.7
Ulcerative Colitis	0.7	1.0	2.3	1.0	-0.8	-0.2	-0.8	-0.6	1.5	-1.5
Blood Eosinophil Count	0.4	3.0	7.1	-1.9	1.4	2.7	1.8	1.3	1.4	-0.9
Blood Platelet Count	0.5	5.5	17.1	-1.8	0.3	1.1	2.1	1.8	4.1	-3.1
Blood Red Count	0.4	3.5	11.8	1.2	-2.3	-0.0	-0.9	-0.8	2.1	-3.4
Blood White Count	0.4	2.8	13.5	-1.0	-0.9	-1.3	0.7	0.4	-3.7	-1.4
Heel T-Score	0.5	3.6	8.1	1.6	-2.8	-1.1	-2.2	-1.8	-0.8	-2.2
BMI	0.9	5.2	17.1	-1.9	0.5	0.3	3.4	4.1	-1.9	0.6
Height	0.2	3.9	15.6	-0.5	2.8	0.5	1.2	1.4	0.2	4.0
Waist Hip Ratio (WHR)	0.1	0.4	0.7	-0.8	0.7	-0.6	0.8	-0.1	-0.3	-0.8
Systolic Blood Pressure	0.3	1.4	6.2	0.3	-0.5	-0.5	1.3	2.5	-0.3	-1.1
Smoking Status	4.0	9.7	15.4	-3.9	2.1	-2.4	3.9	3.1	-3.8	1.8
Allergy or Eczema	0.2	0.6	1.7	-0.4	-0.5	0.9	0.1	0.1	1.1	-1.3
Cardiovascular Disease	0.8	2.5	7.9	-1.0	0.8	0.5	2.3	2.8	-1.6	-0.1
Hypothyroidism (self reported)	0.2	0.4	1.8	0.4	0.6	-0.2	-0.3	-0.5	0.1	1.3
Respiratory disease	0.1	0.2	0.6	-0.8	0.1	0.2	0.7	0.6	0.5	0.1
Type 2 Diabetes (T2D) (2018)	1.3	2.5	5.6	-0.0	1.7	2.4	1.1	1.5	-2.3	0.2
Lung FEV1/FVC ratio	0.2	0.8	2.5	-0.1	0.2	0.6	1.2	1.6	0.7	-0.7
Lung FVC	0.3	1.6	6.3	0.2	-0.1	-1.4	-1.5	-2.5	0.5	0.1
Neuroticism	4.1	9.8	17.0	-3.7	1.3	-2.0	3.8	3.6	-4.1	2.0
Chronotype (morning person)	0.8	1.8	6.7	-0.1	2.0	1.2	0.2	-0.0	0.7	2.6
Hair Pigment	0.2	5.9	12.1	-3.0	2.7	0.6	3.5	3.1	-0.8	1.5
Tanning	0.7	8.3	16.0	3.5	-2.4	-0.2	-4.0	-3.6	3.0	-1.6
Hand grip strength (left)	1.2	3.1	6.9	2.3	-1.4	-1.2	-2.6	-2.2	1.0	0.6
Number of treatments/medications taken	2.7	4.9	11.3	-2.6	0.4	-0.5	3.4	3.2	-2.4	-0.0
Average weekly spirits intake	0.6	0.7	2.7	0.2	-0.5	1.1	0.5	0.8	0.0	-1.6
Sensitivity / hurt feelings	1.3	2.2	5.8	-1.2	0.9	-0.6	1.6	1.6	-2.4	1.4
Frequency of depressed mood in last 2 weeks	1.0	1.3	2.5	-1.1	-1.1	-1.3	1.2	1.6	-0.7	-0.9
Hearing difficulty/problems: Yes	0.3	0.4	1.3	0.5	-0.4	0.5	0.5	1.1	0.5	-0.6
Relative age of first facial hair	0.7	1.5	3.7	-1.9	0.6	0.3	1.7	1.5	-0.5	-1.0
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	3.9	-1.7	1.1	-0.2	1.6	1.2	-2.0	0.7
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.1	-0.8	1.3	1.4	0.1	-0.8	0.0	0.4
Ever had hysterectomy (womb removed)	1.4	1.6	4.5	-1.1	2.1	1.2	1.3	1.1	-0.1	0.8
Systolic blood pressure, automated reading	0.6	1.7	6.0	-0.8	0.0	-0.4	1.9	2.5	-1.1	0.2
Eye problems/disorders: Diabetes related eye disease	3.4	3.7	7.2	-2.1	1.7	1.3	2.7	2.5	-1.8	0.3
Angina	1.7	2.2	4.5	-2.1	0.1	-1.7	1.6	1.4	-1.6	0.7
Medication for hormone replacement therapy	0.6	0.7	1.6	0.1	-0.7	-0.4	-0.9	-1.2	-0.5	-1.2
Vitamin and mineral supplements	1.4	2.0	7.2	0.3	2.0	2.7	0.5	0.9	1.1	-0.5
Supplements: Zinc	0.6	0.6	2.4	-0.7	0.1	-0.7	-0.6	-1.6	0.6	0.4
Medication: Co-codamol	0.9	1.0	3.5	-0.6	0.1	0.2	1.1	1.3	0.3	-1.9
Medication: Metformin	1.4	2.0	4.9	-0.8	1.2	1.1	1.6	1.8	-2.2	0.5
Diabetes (father)	0.5	0.6	1.8	0.0	0.2	1.3	0.6	1.1	-0.7	-0.6
Diabetes (mother)	1.8	2.3	10.5	-0.8	0.6	0.4	1.3	1.7	-3.2	0.5
Severe depression (siblings)	2.0	2.2	4.3	-2.0	0.4	-0.5	2.1	1.8	-1.8	-0.2
Pack years adult smoking proportion	0.2	0.3	1.4	-0.5	0.3	0.3	0.4	0.2	-1.2	-0.3
Impedance of leg (right)	0.2	0.9	1.8	0.2	0.8	1.1	-0.7	-1.4	1.1	-0.9
Leg fat-free mass (left)	0.4	2.3	5.5	-0.9	1.3	0.3	1.9	2.4	-1.0	2.0
Trunk fat percentage	0.9	3.7	10.8	-1.7	0.9	1.2	3.0	3.3	-1.0	0.0
Hand grip strength (right)	0.9	2.4	5.3	2.1	-0.9	-0.8	-2.3	-2.0	1.2	0.0
Townsend deprivation index at recruitment	1.7	2.4	7.6	-1.3	-0.4	-0.6	1.9	1.7	-0.6	-2.8
Current tobacco smoking	1.3	2.1	7.3	-1.8	0.4	-1.3	1.4	0.8	-2.7	-0.1
Average weekly fortified wine intake	0.6	0.7	3.3	-0.3	1.0	-0.1	0.3	0.5	-0.4	1.8
Maternal smoking around birth	0.7	1.0	3.7	-0.4	-0.5	1.2	0.6	0.7	-0.7	-1.9
Fed-up feelings	1.3	2.4	5.9	-0.3	-2.4	-1.8	0.6	0.8	-2.1	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	5.0	-0.4	-1.5	-1.5	1.3	2.0	-2.2	-0.1
Relative age voice broke	0.2	0.3	0.9	0.2	-0.2	1.0	-0.3	-0.4	0.7	-0.7
Taking other prescription medications	3.7	5.7	9.8	-3.1	1.4	-1.5	3.1	2.8	-2.7	1.2
Age when periods started (menarche)	0.7	1.6	3.7	1.4	-0.9	-1.1	-1.7	-1.9	0.2	-0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.1	-0.2	0.3	-1.0	0.2	0.0	-0.2	0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.6	1.7	-1.3	-0.3	-1.9	-1.7	-0.2	-0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.0	-0.4	1.0	0.4	0.4	0.2	-1.0	0.6
Qualifications: CSEs or equivalent	1.0	1.4	5.0	-0.9	-0.1	-1.2	1.0	1.0	-2.2	0.7
Serious illness, injury or assault to yourself	0.8	0.9	2.5	0.9	-0.7	-0.3	-1.0	-0.7	1.0	-1.6
High blood pressure	0.8	2.1	8.9	-0.4	0.3	1.1	2.0	3.0	-0.5	-0.3
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	-0.8	0.5	0.7	0.6	0.4	1.3	0.5
Multivitamins +/- minerals	2.0	2.6	9.8	-0.4	-1.6	-3.1	-0.6	-1.1	-1.2	1.4
Stomach or abdominal pain in last month	2.3	2.8	5.5	-1.2	-0.9	-2.1	1.8	2.0	-2.3	-0.3
Supplements: Glucosamine	0.6	0.8	2.1	-0.6	-1.4	-1.3	-0.1	-0.6	-1.0	-0.1
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.3	-1.5	0.7	0.2	1.5	1.5	-0.2	0.4
Medication: Atenolol	0.8	1.0	2.8	-0.9	0.6	-0.0	1.1	1.2	-1.7	0.7
Medication: Levothyroxine sodium	0.4	0.7	2.8	0.5	1.2	0.8	-0.0	0.1	-0.0	1.7
Sitting height	0.1	0.8	4.2	0.5	0.9	0.3	-0.1	0.5	-0.3	2.0
Chronic bronchitis/emphysema (father)	0.9	1.0	2.8	-0.8	-0.6	-0.9	1.0	1.0	-1.7	0.7
High blood pressure (mother)	0.9	1.3	2.9	-1.3	0.1	-0.8	1.7	1.7	-0.9	-0.1
Body mass index (BMI)	0.9	3.6	11.5	-1.6	0.2	0.8	3.0	3.4	-1.4	-0.4
Impedance of leg (left)	0.2	0.8	2.2	-0.0	0.4	1.1	-0.5	-1.0	0.6	-1.5
Leg predicted mass (left)	0.4	2.4	5.6	-0.9	1.3	0.2	1.9	2.4	-1.1	2.0
Trunk fat mass	0.9	3.9	11.8	-1.6	1.0	1.1	3.0	3.4	-1.3	0.4
Waist circumference	0.9	3.3	9.5	-1.8	0.5	0.7	2.9	3.1	-0.8	-0.5
Number of incorrect matches in round	1.0	1.6	4.2	-1.2	1.9	2.1	1.1	0.5	-0.8	-0.2
Past tobacco smoking	3.0	5.6	10.8	3.1	-1.3	2.4	-3.3	-2.6	1.7	-1.1
Alcohol usually taken with meals	2.5	4.1	11.8	1.8	0.6	1.9	-2.1	-2.0	3.4	1.0
Nervous feelings	4.3	8.1	14.7	-3.6	2.0	-0.9	3.4	2.9	-3.8	2.1
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	8.0	-2.8	0.2	-2.3	2.7	2.3	-2.5	0.8
Hearing difficulty/problems with background noise	0.8	1.3	4.4	-0.6	0.5	0.9	1.4	2.1	0.0	-1.0
Hair/balding pattern: Pattern 2	0.8	1.0	3.3	1.0	0.2	1.8	0.0	0.5	1.5	-0.2
Had menopause	0.9	1.1	2.4	-0.4	1.5	1.5	0.2	-0.2	1.6	1.0
Had other major operations	2.5	3.0	5.8	-2.3	1.2	-1.0	2.1	1.4	-2.4	1.1
Forced vital capacity (FVC)	0.5	2.1	3.9	1.5	-0.3	-1.5	-2.0	-1.9	1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	6.4	2.5	-2.3	-0.6	-2.5	-2.0	0.6	-1.4
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.6	-0.7	0.8	0.3	1.1	1.3	-0.8	0.7
Qualifications: None of the above	1.5	3.1	7.5	-1.7	1.3	0.9	2.7	2.6	-1.2	-0.8
Financial difficulties in last 2 years	1.3	1.8	5.8	-0.0	-1.7	-1.5	-0.2	-0.6	-2.4	-1.1
Mouth/teeth dental problems	2.5	3.8	10.5	2.3	-1.1	0.3	-3.0	-3.2	-0.0	0.4
Heart attack	1.4	1.8	3.3	-1.8	0.4	-1.0	1.8	1.5	-1.4	0.6
Allergy	0.3	0.6	2.0	0.9	-0.4	-0.4	-0.8	-0.7	-1.4	-0.2
Pain all over the body in last month	0.5	0.5	0.9	-0.9	0.2	-0.5	0.9	0.9	0.8	0.4
Diabetes (self-reported)	2.8	4.4	7.3	-1.6	2.7	2.2	2.3	2.3	-2.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	3.6	0.3	-0.1	0.9	-0.2	-0.1	1.9	-0.7
Medication: Ramipril	0.7	0.9	2.1	-0.5	-0.6	-0.6	1.0	1.4	-0.7	-1.4
Medication: Simvastatin	1.3	2.0	4.4	-1.0	0.8	0.2	2.0	2.1	-1.3	1.4
Fluid intelligence score	0.4	0.9	3.4	-0.0	1.1	1.0	-0.0	-0.2	1.8	0.8
Illnesses of siblings	2.2	3.1	7.2	2.2	-1.5	-0.9	-2.7	-2.4	0.8	-0.2
Neuroticism score	2.7	5.7	12.1	-3.0	0.5	-2.0	2.7	2.4	-3.5	1.3
Weight	0.7	3.5	11.0	-1.4	1.0	0.8	2.8	3.3	-1.3	0.8
Impedance of arm (right)	0.3	1.2	2.6	0.9	0.6	0.4	-1.4	-1.6	1.6	-0.5
Arm fat percentage (right)	0.9	3.5	10.5	-1.7	0.5	0.9	3.0	3.2	-1.1	-0.4
Trunk fat-free mass	0.1	0.6	1.8	0.1	0.3	0.1	0.6	1.2	-0.5	1.4
Hip circumference	0.6	2.4	7.8	-1.3	0.6	1.1	2.4	2.8	-0.3	-0.3
Time employed in main current job	1.9	2.2	5.1	2.3	-2.0	-0.6	-2.0	-1.3	0.4	-0.8
Alcohol intake versus 10 years previously	1.7	2.6	5.7	-1.7	1.8	0.8	2.4	2.1	-0.8	0.5
Father’s age at death	2.4	3.2	6.8	2.6	-2.2	-1.5	-2.2	-1.3	1.3	-0.5
Worrier / anxious feelings	4.2	7.9	17.5	-3.6	1.4	-2.1	3.0	2.4	-4.2	2.0
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.9	14.2	-1.3	-0.5	-0.8	2.9	3.8	-1.0	-0.9
Falls in the last year	6.5	8.8	13.9	-3.7	2.2	-0.8	3.5	3.4	-3.1	2.9
Hair/balding pattern: Pattern 3	0.6	0.8	2.0	0.2	-0.6	-1.4	-0.6	-1.2	-0.8	0.9
Number of live births	8.4	11.8	18.8	-3.0	3.7	0.4	4.3	4.3	-3.0	3.7
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.0	1.5	-0.5	-0.5	-1.7	-1.6	1.6	0.2
Pulse rate	0.4	0.7	2.4	1.5	-0.9	-0.4	-0.8	-0.3	0.7	-0.8
Happiness	3.7	4.5	10.4	-2.1	-0.4	-2.7	2.0	1.9	-3.2	1.3
Noisy workplace	0.6	0.7	2.1	0.1	0.4	0.7	0.9	1.4	-1.2	0.2
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.8	1.2	-1.1	-0.8	-1.6	-1.9	0.6	-0.4
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	7.5	-2.6	1.7	0.5	2.7	2.4	-0.8	1.7
Mouth/teeth dental problems: Dentures	3.2	5.3	12.0	-1.9	2.4	1.4	3.2	3.5	0.3	2.0
Asthma	0.3	0.6	1.1	-1.1	0.5	-0.4	1.0	1.0	0.5	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.1	0.1	-2.0	-2.0	-0.1	0.4	-1.1	-0.4
Medication: Cholesterol lowering	0.2	0.4	1.1	-0.3	-0.1	-0.5	0.6	0.7	-1.1	0.6
Depression (self-reported)	2.7	3.2	9.6	-2.3	0.3	-2.0	1.6	1.0	-3.1	-0.3
Medication: Lansoprazole	1.7	2.0	4.8	-1.4	0.6	-0.4	1.9	2.2	-1.5	0.9
Prospective memory result	1.5	1.9	5.1	-1.3	1.0	-0.3	1.7	1.4	-2.3	-0.8
Lung cancer (father)	1.6	1.8	3.9	-1.7	1.0	-0.2	2.0	1.5	-1.2	1.2
Illnesses of mother	1.7	2.1	5.9	1.2	-0.9	0.1	-1.8	-2.4	1.8	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.1	1.4	-0.3	-0.4	-1.4	-1.4	0.7	0.7
Pulse wave Arterial Stiffness index	1.8	2.1	6.8	-0.8	0.4	-1.0	1.9	2.6	-0.9	1.4
Impedance of arm (left)	0.2	0.9	2.2	0.8	0.5	0.5	-1.1	-1.2	1.5	-0.6
Arm fat mass (right)	0.7	2.9	9.5	-1.4	0.4	0.7	2.7	3.1	-1.1	-0.2
Trunk predicted mass	0.1	0.6	1.9	0.0	0.3	0.1	0.6	1.2	-0.5	1.4
Standing height	0.1	1.2	5.7	0.6	1.5	0.1	-0.3	0.1	0.4	2.4
Length of working week for main job	0.7	0.8	1.8	0.0	-1.2	-1.4	-0.7	-1.3	-0.1	-0.0
Exposure to tobacco smoke at home	3.2	3.6	9.9	-3.1	0.9	-1.0	2.8	2.1	-1.0	0.6
Breastfed as a baby	0.9	1.1	4.3	0.3	-0.3	-1.5	-0.5	-0.2	1.0	2.1
Tense / ‘highly strung’	5.1	8.5	11.7	-3.4	2.9	-1.2	3.1	3.1	-2.9	3.3
Seen doctor (GP) for nerves, anxiety, tension or depression	3.4	5.2	9.7	-3.1	2.6	0.1	3.1	2.5	-1.7	1.0
Hair/balding pattern: Pattern 4	1.1	2.6	8.6	-1.1	1.6	1.0	1.4	0.9	-2.9	1.4
Birth weight of first child	0.9	1.6	6.4	0.3	-0.7	-1.9	-0.7	-0.3	-2.5	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.6	0.6	-0.7	-0.6	-0.6	-0.5	0.8	-0.2
Pulse wave reflection index	0.8	1.0	2.4	-1.0	0.6	-0.6	1.1	1.4	0.1	1.5
Ever highly irritable/argumentative for 2 days	4.7	5.6	9.1	-2.7	2.0	-0.5	3.0	2.5	-3.0	1.9
Loud music exposure frequency	0.1	0.1	0.5	0.1	-0.2	-0.0	0.3	0.7	-0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.4	0.3	-1.1	0.2	-0.9	-1.6	0.3	-1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	-0.3	-0.2	-1.3	0.1	0.2	-0.9	-1.3
Blood clot in the leg (DVT)	0.4	0.5	1.2	1.0	-0.6	0.6	-0.5	-0.0	0.8	-1.1
Medication: Paracetamol	1.5	2.4	6.2	-1.8	0.6	-0.4	2.5	2.3	-1.2	0.4
Headache pain in last month	0.6	1.0	3.4	-0.8	-0.0	-0.5	1.6	1.9	-0.5	-0.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.6	-0.5	0.8	-0.2	-0.6	-1.3	1.1	0.3
Glaucoma (self-reported)	0.5	0.6	2.3	1.5	-0.1	0.2	-1.1	-0.8	0.2	0.3
Gout (self-reported)	1.0	1.3	4.5	1.2	-0.5	2.1	-0.7	0.2	0.0	-1.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.5	0.9	0.5	-0.0	-0.3	-0.3	-0.1	1.2
Medication: Amlodipine	0.3	0.5	1.6	0.1	-0.5	0.2	0.6	0.8	-0.6	-1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.6	-0.6	1.7	0.9	1.4	1.9	-0.1	0.9
Birth weight	0.2	0.4	2.0	0.6	0.0	0.4	-0.3	-0.0	-1.4	0.2
Chronic bronchitis/emphysema (mother)	3.1	3.6	7.6	-1.5	2.5	2.8	1.9	2.0	-1.2	0.6
High blood pressure (siblings)	0.2	0.3	1.2	-0.1	-0.0	-0.0	0.6	1.1	0.6	-0.4
Forced vital capacity (FVC), Best measure	0.5	1.8	3.4	1.5	-0.4	-1.3	-1.8	-1.8	0.4	1.2
Body fat percentage	1.0	4.1	11.2	-1.9	0.8	1.3	3.2	3.3	-1.2	-0.4
Leg fat percentage (right)	1.5	5.5	12.9	-2.4	1.1	1.9	3.6	3.6	-1.3	-0.8
Arm fat-free mass (right)	0.3	1.7	4.6	-0.6	0.7	0.4	1.6	2.1	-1.2	1.4
Exposure to tobacco smoke outside home	1.3	1.7	3.3	-1.8	0.5	-0.7	1.8	1.2	-1.7	0.3
Comparative body size at age 10	0.1	0.4	1.3	-0.4	0.1	-1.1	-0.1	-0.3	0.8	0.8
Number of full brothers	1.6	2.1	6.4	-0.4	0.0	0.7	2.0	2.5	-1.7	0.5
Worry too long after embarrassment	0.5	0.8	2.1	-0.7	-0.3	-0.5	1.4	1.5	-0.8	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	4.0	-0.8	-0.7	-0.4	1.0	0.8	-2.0	-0.7
Wheeze or whistling in the chest in last year	2.7	4.8	11.2	-2.4	1.2	-0.1	2.9	3.3	-2.3	1.1
Number of children fathered	0.9	1.0	3.5	0.6	-0.7	-1.6	-0.5	0.1	0.3	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.4	0.1	-0.1	0.1	-1.1	-1.5	1.5	0.2
Age at first live birth	3.3	5.8	12.0	3.3	-1.5	0.1	-3.5	-3.0	2.4	-1.1
Pulse wave peak to peak time	1.6	1.9	6.2	0.7	-0.1	1.2	-1.8	-2.5	0.8	-1.3
Health satisfaction	3.0	3.9	9.2	-0.9	-0.7	-2.7	1.7	2.3	-3.0	1.1
Shortness of breath walking on level ground	0.4	0.5	1.0	-0.8	0.3	-0.2	1.0	1.0	-0.9	0.2
Qualifications: College or University degree	1.2	3.7	7.2	1.9	0.3	1.3	-2.5	-2.6	2.7	0.1
Eye problems/disorders: None of the above	0.7	0.8	1.4	1.1	-0.7	0.3	-0.9	-0.8	1.0	-1.2
Mouth/teeth dental problems: Loose teeth	1.8	2.2	9.2	-1.0	-1.2	-3.0	0.4	0.4	-1.5	-1.1
Emphysema/chronic bronchitis	0.4	0.5	2.7	-0.1	-0.3	0.0	0.3	0.6	0.1	-1.6
Medication for pain relief, constipation, heartburn	4.0	6.8	13.3	3.1	-0.3	1.4	-3.6	-3.6	2.9	-1.1
Neck or shoulder pain in last month	2.7	3.9	7.3	-2.6	0.7	-1.0	2.7	2.5	-2.1	-0.7
Medication: Blood pressure	0.9	1.5	5.4	-0.3	0.4	1.2	1.6	2.3	-0.8	-0.3
Angina (self-reported)	1.8	2.4	5.3	-2.3	0.1	-1.6	1.7	1.5	-1.7	0.6
Migraine (self-reported)	0.9	1.1	2.0	-1.1	0.5	1.0	1.2	1.0	0.6	-1.4
Medication: Ibuprofen	1.3	1.6	5.0	-0.5	-1.7	-2.2	0.1	0.3	-1.7	-0.2
Medication: Allopurinol	0.6	0.8	3.3	1.0	-0.0	1.8	-0.6	0.2	0.7	-0.9
Medication: Omeprazole	1.2	1.4	2.9	-1.5	1.3	0.4	1.7	1.4	-0.3	0.8
Medication: Seretide 50 evohaler	1.2	1.4	3.1	-1.6	0.4	-1.4	1.1	0.3	0.8	1.8
Mean time to correctly identify matches	0.2	0.3	1.3	-0.2	1.1	0.8	-0.0	-0.2	-0.3	0.4
Heart disease (mother)	0.4	0.5	1.3	0.3	0.1	0.5	0.4	1.0	-1.2	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.9	-0.7	-0.1	1.3	0.9	0.6	1.5	-2.0
Whole body fat mass	0.9	3.6	11.2	-1.6	0.7	1.0	2.9	3.3	-1.3	-0.1
Leg fat mass (right)	1.3	4.9	12.8	-2.0	1.2	1.4	3.4	3.6	-1.6	-0.0
Arm predicted mass (right)	0.3	1.8	5.2	-0.6	0.7	0.4	1.8	2.3	-1.2	1.2
Pulse rate, automated reading	0.4	1.2	5.2	0.3	0.5	0.6	1.5	2.3	0.3	-0.6
Alcohol intake frequency.	3.4	8.0	13.9	-2.2	3.2	3.6	3.5	3.7	-1.3	0.6
Comparative height size at age 10	0.2	1.2	3.1	0.4	1.8	1.1	0.4	1.0	0.6	1.6
Number of full sisters	2.0	2.4	5.6	-1.5	0.9	0.4	2.2	2.4	-1.8	-0.1
Suffer from ‘nerves’	5.4	8.5	20.2	-4.0	1.1	-2.5	3.0	2.2	-4.5	1.5
Overall health rating	7.6	16.3	42.3	-4.2	1.6	-0.7	5.9	6.5	-4.0	0.8
Chest pain or discomfort	5.4	7.8	20.6	-3.0	0.8	-1.3	4.0	4.5	-2.4	0.5
Had major operations	4.4	5.2	8.0	-2.1	1.9	-1.1	2.6	2.8	-2.8	2.1
Age at last live birth	0.5	0.8	2.5	0.9	0.3	-0.0	-1.3	-1.6	0.5	0.1
Family relationship satisfaction	1.4	1.8	5.7	-0.4	-0.7	-2.4	-0.9	-1.5	-1.6	0.8
Leg pain on walking	3.0	3.8	6.9	-2.6	1.0	-1.0	2.6	2.2	-2.0	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	5.5	-0.3	-0.8	-1.7	-0.1	-0.5	-2.3	0.0
Commuting to job workplace: Car/motor vehicle	1.1	1.2	2.8	0.6	-1.7	-1.3	-0.8	-0.5	-1.6	0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	-0.7	0.6	-0.0	0.0	-0.2	-0.5	0.9
Medication: Aspirin	1.4	1.8	3.7	-1.6	0.4	1.1	1.9	1.8	-0.9	-0.9
Supplements: Vitamin C	1.2	1.4	2.1	1.0	-1.4	-0.8	-1.4	-1.3	1.2	-1.1
Knee pain experienced in last month	3.9	6.1	12.4	-2.7	1.2	-0.2	3.5	3.5	-3.0	0.3
Hypertension (Self-reported)	1.1	3.0	11.4	-0.8	0.7	1.4	2.5	3.4	-0.8	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	4.8	-2.0	2.0	-0.5	2.1	2.2	-1.4	1.9
Illnesses of father: Heart disease	0.3	0.4	1.4	-0.8	-0.2	-0.9	0.2	0.2	-1.2	0.4
Illnesses of siblings: Diabetes	1.0	1.3	5.1	-0.2	1.2	2.3	1.0	0.9	-0.7	-0.4
Smoking status: Previous	2.0	3.0	5.5	-2.3	0.7	-2.1	2.3	1.9	-0.4	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	0.4	-0.4	0.4	-0.3	-0.4	0.3	-0.7
Whole body fat-free mass	0.2	1.4	3.4	-0.5	0.8	0.2	1.3	1.8	-0.9	1.8
Leg fat-free mass (right)	0.4	2.1	5.5	-0.8	1.0	0.1	1.8	2.3	-1.2	1.7
Arm fat percentage (left)	1.0	3.8	11.4	-1.7	0.5	1.0	3.1	3.4	-1.2	-0.5
Average weekly red wine intake	0.4	0.6	2.1	-1.5	0.9	-0.7	0.2	-0.5	0.3	0.7
Handedness (chirality/laterality): Left-handed	2.6	3.2	5.4	1.8	-1.7	-0.1	-2.2	-2.1	2.3	-1.2
Mood swings	2.5	4.5	10.4	-2.5	0.5	-1.3	2.6	2.4	-3.2	0.1
Loneliness, isolation	0.5	0.7	2.3	-1.5	-0.1	0.1	1.2	0.9	-0.2	-0.5
Long-standing illness, disability or infirmity	2.6	4.0	8.4	-2.3	0.9	-0.6	2.9	2.8	-2.3	0.2
Ever had bowel cancer screening	3.3	3.9	6.6	-1.9	1.4	-0.5	2.4	2.6	-2.0	2.2
Diabetes diagnosed by doctor	2.6	4.3	7.1	-1.2	2.7	2.6	2.0	2.2	-2.1	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.4	-0.4	0.0	-1.5	0.1	-0.5	0.3	1.6
Friendships satisfaction	2.5	3.1	10.4	-1.1	-0.1	-2.9	0.5	0.2	-3.2	1.1
Qualifications: nursing, teaching	0.8	1.2	2.8	-1.3	1.7	0.7	0.6	0.0	-0.6	1.7
Commuting to job workplace: Walk	0.5	0.5	1.4	0.4	-0.3	-0.1	-0.8	-1.2	1.2	-0.3
Eye problems/disorders: Cataract	0.7	0.8	1.8	-1.4	0.4	-1.1	0.9	0.7	-0.5	0.9
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	4.0	-0.3	-0.4	0.2	1.4	2.0	0.7	-1.2
Medication for cholesterol	0.3	0.5	0.9	0.3	-0.8	-0.8	-0.7	-1.0	0.9	-0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	6.8	-1.6	0.4	-0.8	1.7	1.7	-2.6	0.8
Back pain experienced in last month	3.0	4.4	10.0	-3.2	0.1	-1.3	3.2	2.8	-1.1	0.5
Mineral and other dietary supplements	0.5	0.7	1.7	1.3	0.2	0.8	-0.3	0.3	1.0	-1.1
Breast cancer (self-reported)	3.1	3.7	5.9	-2.0	2.2	1.7	2.4	2.4	0.6	1.5
Asthma (self-reported)	0.2	0.5	0.9	-1.0	0.3	-0.4	0.9	0.9	0.4	0.7
Osteoporosis (self-reported)	1.4	1.8	5.9	-1.1	1.0	0.7	1.7	2.4	-0.8	0.4
Osteoarthritis (self-reported)	4.4	5.7	10.8	-3.3	1.1	-0.9	3.2	2.8	-2.9	0.8
Medication: Aspirin	1.0	1.2	2.6	-1.3	-0.1	0.5	1.5	1.6	-1.1	-0.9
Medication: Gliclazide	0.4	0.5	1.1	1.0	-1.1	-0.5	-0.3	0.2	-0.9	0.3
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.6	1.2	-0.3	0.8	0.4	-0.3	1.1
Smoking status: Current	1.4	2.2	7.3	-1.7	0.2	-1.4	1.5	0.9	-2.7	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.4	1.6	-0.1	0.9	-1.3	-1.0	1.2	-0.2
Whole body water mass	0.3	1.5	3.5	-0.5	0.9	0.2	1.3	1.9	-0.9	1.8
Leg predicted mass (right)	0.4	2.1	5.4	-0.8	1.1	0.1	1.8	2.3	-1.2	1.8
Arm fat mass (left)	1.0	4.0	12.6	-1.7	0.7	1.0	3.1	3.5	-1.2	-0.0
Number of self-reported non-cancer illnesses	4.6	8.0	17.4	-2.9	2.3	1.9	4.0	4.2	-2.4	0.3
Average weekly champagne plus white wine intake	1.7	2.3	5.7	1.8	0.7	2.4	-1.2	-0.4	1.9	1.0
Miserableness	1.0	1.7	5.7	-0.2	-1.8	-1.5	0.0	-0.1	-0.7	-2.4
Guilty feelings	2.7	4.1	6.8	-2.6	0.6	-1.8	2.6	2.2	-2.4	1.1
Wears glasses or contact lenses	2.1	2.5	4.8	1.6	-2.0	-1.3	-1.6	-1.3	2.2	-0.2
Ever taken oral contraceptive pill	2.2	2.5	8.5	1.0	-2.2	-2.9	-1.4	-1.2	0.1	-0.2
Hearing aid user	1.2	1.3	3.8	1.7	-1.9	-0.1	-0.6	0.4	-0.0	-1.4
Mother’s age at death	0.7	0.9	1.7	0.9	-0.2	-0.8	-1.3	-1.2	0.8	0.9
Financial situation satisfaction	1.4	1.8	5.5	-0.3	-1.8	-2.3	-0.0	-0.1	-1.7	-0.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.9	0.4	0.0	0.8	0.1	0.4	-0.1	-0.9
Commuting to job workplace: Public transport	1.3	1.6	3.0	1.3	-1.5	-1.1	-1.1	-0.8	1.0	-1.7
Eye problems/disorders: Glaucoma	0.3	0.4	1.3	1.1	0.1	0.7	-0.7	-0.3	0.4	0.1
Medication: Blood pressure	0.6	1.1	3.7	-0.2	0.8	1.9	0.9	1.2	0.7	-1.0
Pain type(s) experienced in last month: Hip pain	2.2	2.7	7.5	-1.9	0.1	-1.3	1.9	1.5	-2.7	-0.3
Supplements: Fish oil (including cod liver oil)	1.0	1.3	2.8	0.8	-1.6	-1.1	-1.4	-1.7	0.0	-0.3
High cholesterol (Self-reported)	1.9	3.4	5.1	-1.9	2.0	-0.1	2.1	1.8	-1.9	2.3
Medication: Bendroflumethiazide	0.7	1.1	3.2	0.2	0.3	1.2	0.6	1.4	1.8	0.7
Medication: Paracetamol	1.8	2.8	5.8	-2.0	0.9	-0.8	2.4	2.2	-1.6	1.0
Medication: Lisinopril	1.9	2.5	7.0	-0.8	1.4	1.7	2.0	2.6	-0.9	0.1
Medication: Atorvastatin	0.3	0.4	1.3	0.3	0.4	0.4	-0.7	-0.8	-1.1	-0.5
Illnesses of father: High blood pressure	0.4	0.4	1.1	0.6	-0.7	-0.3	0.1	1.0	0.8	-0.7
Alcohol drinker status: Never	1.7	2.0	4.2	-0.5	1.7	2.0	1.3	2.1	0.1	0.9
Ever smoked	2.0	3.5	6.9	-2.6	1.3	-2.2	2.5	1.5	-1.1	1.2
Basal metabolic rate	0.3	1.8	5.3	-0.8	0.9	0.4	1.8	2.3	-1.0	1.4
Leg fat percentage (left)	1.6	5.9	14.4	-2.4	0.9	1.9	3.7	3.8	-1.6	-1.0
Arm fat-free mass (left)	0.4	1.8	4.6	-0.9	0.7	0.2	1.7	2.1	-1.2	1.4
Number of operations (self-reported)	2.0	2.9	6.2	-1.6	1.5	0.0	2.3	2.5	-2.0	0.3
Average weekly beer plus cider intake	2.6	3.8	8.4	0.7	-2.6	-2.9	-0.7	-0.2	-1.7	-2.7
Irritability	1.4	2.3	9.3	0.3	-1.9	-3.1	-0.8	-0.8	-1.4	-0.0
Risk taking	0.9	1.3	3.7	0.8	-1.1	-0.9	-1.7	-1.9	0.1	-0.2
Ever had prostate specific antigen (PSA) test	1.9	2.2	7.8	-0.8	-0.8	-2.8	-0.5	-1.1	-0.8	2.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.1	0.0	-0.4	-0.3	-0.3	-0.3	-0.4
Age started oral contraceptive pill	0.5	0.6	2.0	0.0	0.4	0.2	-0.8	-1.4	1.0	0.4
Diastolic blood pressure, automated reading	0.8	2.4	6.4	-1.2	0.3	-0.7	2.1	2.5	-1.8	0.9
Ever depressed for a whole week	2.1	2.6	7.9	-1.6	0.9	-0.9	1.8	1.6	-2.8	0.5
Unable to work because of sickness or disability	2.4	3.1	7.1	-1.7	-0.1	-0.3	2.7	2.6	-1.9	-1.1
Commuting to job workplace: Cycle	2.1	2.5	6.3	1.3	-0.2	0.1	-2.0	-2.4	2.5	-0.4
Myopia	0.6	0.9	1.7	0.9	-0.8	0.8	-0.8	-1.1	1.3	-0.9
Vascular/heart problems diagnosed by doctor	1.1	2.9	10.2	1.1	-0.6	-1.2	-2.5	-3.2	1.1	0.2
Cholesterol lowering medication	3.0	4.4	6.8	-2.4	2.1	0.5	2.6	2.3	-2.6	1.4
Medication: Omeprazole (e.g. Zanprol)	2.9	3.6	7.5	-2.6	1.9	0.0	2.7	2.1	-1.1	1.0
Pain experienced in last month	4.3	7.1	18.0	2.9	-0.5	1.8	-3.9	-4.2	2.0	-0.8
Supplements: Calcium	0.7	0.8	2.0	-1.4	0.5	0.9	1.3	1.0	-0.3	-0.2
Basal cell carcinoma (self-reported)	0.5	0.6	2.7	0.1	0.7	1.6	-0.5	-0.8	0.2	-0.2
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.5	-1.6	0.4	-0.7	1.6	1.4	-1.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.4	1.2	-0.5	0.9	-0.6	-0.1	1.0	-1.0
Heart disease (siblings)	2.7	3.4	8.4	-2.0	0.7	1.1	2.9	2.7	-1.2	-0.7
Alcohol drinker status: Previous	4.5	5.1	16.2	-2.0	3.0	4.0	2.0	1.5	-0.1	-0.4
Pack years of smoking	0.2	0.2	0.6	-0.4	0.4	0.6	0.4	0.2	-0.8	-0.2
Impedance of whole body	0.2	0.9	1.8	0.6	0.4	0.7	-1.0	-1.3	1.1	-1.1
Leg fat mass (left)	1.4	5.3	14.0	-2.1	1.2	1.5	3.5	3.7	-1.7	-0.2
Arm predicted mass (left)	0.3	1.7	4.8	-0.9	0.7	0.3	1.8	2.2	-1.2	1.2