Hub : Genes

MAPK4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.2040 0.0690 0.0014 0.172 NA 0.140 NA 0.175 9.4e-10 NA 4.0e-08 NA 6.1e-10
2 TCGA Prostate Adenocarcinoma 0.0516 0.0239 0.0038 -0.002 0.018 0.003 NA -0.001 5.5e-01 0.0049 1.6e-01 NA 3.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.1 0.2 0.4 0.6 0.1
Bipolar Disorder or Schizophrenia 0.4 1.0 1.7 1.3 0.6
Depressed Affect (Nagel 2018) 0.2 0.4 0.5 -0.7 0.4
Depression (Nagel 2018) 0.0 0.0 0.0 0.1 0.1
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.1 -1.1 -0.7
Neuroticism (Nagel 2018) 0.2 0.5 0.9 -0.4 -0.9
Schizophrenia (2018) 0.5 1.0 1.4 1.2 0.8
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 -0.2 0.4
Worry (Nagel 2018) 1.4 3.0 4.9 -1.1 -2.2
Alzheimer’s Disease (in mother) 0.1 0.2 0.3 -0.1 0.6
Alzheimer’s Disease (in father) 0.0 0.0 0.1 0.3 0.1
Alzheimer’s Disease (including proxy) 0.1 0.1 0.1 0.3 -0.2
Crohns Disease (2017) 0.1 0.2 0.3 0.3 -0.5
Irritable Bowel Disease (IBD) 0.1 0.2 0.3 0.6 -0.4
Ulcerative Colitis (UC) 0.0 0.1 0.1 0.3 0.2
Major Depression (MDD) 0.5 0.6 0.8 0.7 0.9
Reaction Time 1.4 2.6 3.3 -1.8 -1.4
Verbal and Numeric Reasoning (VNR) 0.2 0.4 0.7 -0.8 -0.2
Breast Cancer 0.0 0.1 0.1 -0.2 0.4
Ovarian Cancer 1.1 1.4 2.9 -1.7 0.1
Prostate Cancer 0.6 0.8 1.2 1.1 0.7
Age at First Birth 0.5 0.7 1.4 1.2 -0.1
Bipolar Disorder (2011) 0.2 0.2 0.4 0.6 0.3
Body Mass Index (BMI) (2010) 0.4 0.5 0.9 0.2 1.0
Coronary Artery Disease (CAD) 1.8 2.2 2.8 -1.2 -1.7
Crohns Disease (2012) 0.0 0.0 0.0 0.0 0.2
Mean Putamen Volume 0.6 0.7 1.4 -0.1 1.2
Fasting Glucose 0.6 0.7 1.3 0.1 1.1
HbA1C 1.1 1.2 1.7 1.3 0.9
HDL Cholesterol 1.0 1.6 1.8 1.3 1.2
LDL Cholesterol 0.1 0.1 0.2 -0.5 -0.2
Lupus 0.5 0.7 1.4 0.2 -1.2
Neuroticism (2016) 0.3 0.5 0.8 0.9 -0.4
Primary Biliary Cirrhosis 2.5 3.6 5.3 -2.3 -1.4
Rheumatoid Arthritis 0.0 0.0 0.1 -0.0 0.3
Schizophrenia (2014) 0.9 2.0 2.8 1.7 1.1
Triglycerides 0.3 0.4 0.8 -0.9 0.3
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.9 -0.9 -0.4
Ulcerative Colitis 0.3 0.4 0.7 0.2 0.8
Blood Eosinophil Count 0.9 7.3 13.8 -3.7 -0.9
Blood Platelet Count 0.0 0.3 0.5 -0.7 0.4
Blood Red Count 0.5 4.8 8.6 -2.9 -1.0
Blood White Count 0.8 5.9 5.9 -2.4 2.4
Heel T-Score 0.0 0.4 0.7 -0.8 -0.2
BMI 0.4 2.2 3.2 -1.1 1.8
Height 0.0 0.0 0.0 0.2 -0.2
Waist Hip Ratio (WHR) 0.1 0.6 1.0 0.3 1.0
Systolic Blood Pressure 4.8 23.8 44.4 -6.7 -1.8
Smoking Status 1.0 2.3 3.1 1.2 1.8
Allergy or Eczema 1.2 3.1 5.2 -2.3 -1.0
Cardiovascular Disease 0.6 2.0 2.8 -1.7 -1.1
Hypothyroidism (self reported) 0.7 1.5 2.9 0.5 -1.7
Respiratory disease 1.8 3.9 5.6 1.5 2.4
Type 2 Diabetes (T2D) (2018) 0.1 0.1 0.1 0.3 -0.3
Lung FEV1/FVC ratio 2.1 10.5 15.1 -3.9 -2.4
Lung FVC 0.9 4.8 7.2 -2.7 -1.5
Neuroticism 0.4 0.9 1.1 -0.8 -1.0
Chronotype (morning person) 0.5 1.1 2.2 1.5 -0.2
Hair Pigment 0.0 0.2 0.3 -0.6 0.1
Tanning 0.2 2.4 4.1 0.9 2.0
Hand grip strength (left) 0.1 0.2 0.3 0.5 -0.3
Number of treatments/medications taken 0.6 1.1 1.3 1.0 1.1
Average weekly spirits intake 0.2 0.2 0.5 -0.0 0.7
Sensitivity / hurt feelings 0.3 0.5 0.7 -0.8 -0.5
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.1 1.1 0.6
Hearing difficulty/problems: Yes 1.9 2.9 5.5 2.3 -0.6
Relative age of first facial hair 1.2 2.5 2.6 1.6 1.6
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 1.1 1.0 0.9
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.1 1.1 0.4
Ever had hysterectomy (womb removed) 3.4 3.9 6.1 1.3 2.5
Systolic blood pressure, automated reading 3.9 11.3 22.4 -4.7 -0.5
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 0.8 -0.9 0.8
Angina 0.1 0.1 0.2 -0.2 -0.5
Medication for hormone replacement therapy 0.1 0.1 0.1 0.3 0.3
Vitamin and mineral supplements 0.1 0.1 0.2 0.3 -0.5
Supplements: Zinc 0.6 0.6 1.2 -1.1 -0.0
Medication: Co-codamol 7.4 8.6 10.5 2.6 3.2
Medication: Metformin 0.0 0.1 0.1 0.3 0.0
Diabetes (father) 0.4 0.5 1.0 0.1 -1.0
Diabetes (mother) 1.4 1.8 2.0 1.3 1.4
Severe depression (siblings) 0.7 0.8 1.4 -1.2 -0.5
Pack years adult smoking proportion 0.3 0.4 0.6 -0.6 0.7
Impedance of leg (right) 0.1 0.6 0.6 -0.8 -0.7
Leg fat-free mass (left) 0.1 0.4 0.7 0.3 0.8
Trunk fat percentage 0.4 1.7 2.4 -1.6 1.0
Hand grip strength (right) 0.0 0.1 0.1 -0.3 -0.3
Townsend deprivation index at recruitment 0.0 0.0 0.0 0.2 -0.1
Current tobacco smoking 0.3 0.5 0.6 0.8 0.7
Average weekly fortified wine intake 0.2 0.2 0.4 -0.3 0.6
Maternal smoking around birth 0.1 0.2 0.2 0.5 0.3
Fed-up feelings 0.1 0.3 0.4 0.6 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 -0.7 -0.1
Relative age voice broke 0.0 0.0 0.0 -0.2 -0.1
Taking other prescription medications 0.4 0.6 0.7 0.9 0.7
Age when periods started (menarche) 0.5 1.3 2.4 0.4 1.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.2 -0.2 1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.1 5.5 -2.4 -0.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 0.3 0.1
Qualifications: CSEs or equivalent 0.5 0.7 1.3 -0.0 1.1
Serious illness, injury or assault to yourself 1.7 2.0 3.6 0.7 1.9
High blood pressure 0.4 1.1 1.8 -1.4 0.5
Hayfever, allergic rhinitis or eczema 2.1 4.6 8.5 -2.9 -0.8
Multivitamins +/- minerals 0.6 0.7 1.1 0.6 1.0
Stomach or abdominal pain in last month 0.9 1.2 1.3 1.1 1.0
Supplements: Glucosamine 0.4 0.5 0.9 -0.2 1.0
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.6 0.8 0.0
Medication: Atenolol 1.2 1.4 1.9 1.4 1.0
Medication: Levothyroxine sodium 0.5 0.9 1.7 -0.2 -1.3
Sitting height 0.1 1.0 1.4 0.8 -1.2
Chronic bronchitis/emphysema (father) 2.3 2.7 2.7 1.6 1.7
High blood pressure (mother) 2.0 2.8 3.8 -2.0 -1.3
Body mass index (BMI) 0.5 2.0 2.3 -1.3 1.5
Impedance of leg (left) 0.1 0.6 0.6 -0.7 -0.8
Leg predicted mass (left) 0.1 0.4 0.8 0.3 0.9
Trunk fat mass 0.4 1.5 1.9 -1.4 1.1
Waist circumference 0.5 2.0 3.8 -0.4 2.0
Number of incorrect matches in round 0.0 0.0 0.0 0.2 -0.2
Past tobacco smoking 0.5 0.8 1.4 -0.5 -1.2
Alcohol usually taken with meals 0.2 0.4 0.6 0.8 -0.4
Nervous feelings 0.1 0.2 0.3 0.3 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.2 0.4 -0.5
Hearing difficulty/problems with background noise 0.6 1.0 2.0 1.4 -0.2
Hair/balding pattern: Pattern 2 3.7 4.7 5.1 -2.1 -2.3
Had menopause 0.5 0.6 1.2 1.1 0.2
Had other major operations 0.2 0.2 0.4 0.6 -0.1
Forced vital capacity (FVC) 1.4 5.2 8.3 -2.9 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 1.8 4.2 7.1 -2.7 -1.1
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 2.1 1.4 1.3
Qualifications: None of the above 0.7 1.4 2.9 -0.1 1.7
Financial difficulties in last 2 years 0.1 0.2 0.4 -0.6 -0.1
Mouth/teeth dental problems 0.7 1.0 1.9 1.4 0.2
Heart attack 0.9 1.2 2.3 -1.5 -0.1
Allergy 0.7 1.6 3.0 1.7 -0.4
Pain all over the body in last month 0.8 0.9 1.7 1.3 -0.2
Diabetes (self-reported) 0.3 0.4 0.8 0.9 -0.0
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 0.8 -0.9 -0.6
Medication: Ramipril 0.9 1.2 1.8 -0.7 1.4
Medication: Simvastatin 0.5 0.7 0.8 -0.9 -0.8
Fluid intelligence score 0.1 0.2 0.5 -0.7 0.1
Illnesses of siblings 0.1 0.1 0.2 0.4 0.3
Neuroticism score 0.8 1.7 1.9 -1.4 -1.3
Weight 0.2 1.0 1.3 -0.9 1.1
Impedance of arm (right) 0.1 0.5 1.0 -0.1 -1.0
Arm fat percentage (right) 0.3 1.4 1.4 -1.2 1.2
Trunk fat-free mass 0.1 0.4 0.9 0.1 0.9
Hip circumference 0.3 1.1 1.6 -1.3 0.8
Time employed in main current job 0.1 0.1 0.1 -0.3 -0.0
Alcohol intake versus 10 years previously 0.1 0.1 0.2 0.5 0.1
Father’s age at death 1.5 2.1 2.7 1.6 1.2
Worrier / anxious feelings 1.7 3.3 3.9 -1.6 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 1.1 -0.6 1.0
Falls in the last year 0.2 0.3 0.5 -0.7 0.2
Hair/balding pattern: Pattern 3 0.7 1.0 1.6 1.3 0.6
Number of live births 0.2 0.2 0.4 -0.3 -0.6
Forced expiratory volume in 1-second (FEV1) 2.1 7.2 9.9 -3.1 -2.1
Pulse rate 1.0 1.7 3.0 1.7 0.7
Happiness 0.3 0.4 0.4 0.6 0.6
Noisy workplace 0.3 0.3 0.4 -0.5 -0.6
Qualifications: A levels/AS levels or equivalent 0.8 1.7 2.0 1.4 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.2 -1.5 0.3
Mouth/teeth dental problems: Dentures 1.0 1.6 2.0 -1.4 -1.1
Asthma 0.4 0.9 1.0 0.9 1.0
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 1.3 -1.1 -0.9
Medication: Cholesterol lowering 1.0 1.6 3.0 -1.7 -0.5
Depression (self-reported) 3.4 4.1 7.3 0.9 2.7
Medication: Lansoprazole 0.9 1.0 1.5 -0.8 -1.2
Prospective memory result 1.0 1.3 1.5 -1.2 -1.1
Lung cancer (father) 0.2 0.3 0.3 -0.4 -0.6
Illnesses of mother 0.7 0.8 1.5 -0.4 -1.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.3 7.2 10.8 -3.3 -1.9
Pulse wave Arterial Stiffness index 0.2 0.2 0.4 0.1 -0.6
Impedance of arm (left) 0.2 0.7 1.3 -0.3 -1.1
Arm fat mass (right) 0.4 1.5 2.0 -1.0 1.4
Trunk predicted mass 0.1 0.5 1.0 0.1 1.0
Standing height 0.0 0.4 0.6 0.4 -0.8
Length of working week for main job 2.5 2.7 3.3 -1.8 -1.5
Exposure to tobacco smoke at home 0.7 0.8 1.0 -0.8 -1.0
Breastfed as a baby 0.5 0.7 0.8 0.7 0.9
Tense / ‘highly strung’ 0.7 1.1 1.8 -0.6 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.8 1.7 0.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 -0.6 0.4
Birth weight of first child 0.2 0.4 0.6 0.5 -0.7
Peak expiratory flow (PEF) 1.6 3.7 4.5 -2.1 -1.7
Pulse wave reflection index 0.2 0.3 0.4 0.5 0.6
Ever highly irritable/argumentative for 2 days 0.1 0.2 0.3 -0.2 0.6
Loud music exposure frequency 1.5 1.6 3.2 0.0 -1.8
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 2.9 1.7 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.3 -1.1 -0.1
Blood clot in the leg (DVT) 0.3 0.3 0.7 -0.8 0.0
Medication: Paracetamol 0.5 0.9 1.6 -0.3 1.3
Headache pain in last month 0.1 0.3 0.5 -0.7 0.1
Medication for cholesterol, blood pressure or diabetes 1.2 2.0 2.2 1.4 1.5
Glaucoma (self-reported) 0.8 0.9 1.9 -1.4 -0.0
Gout (self-reported) 0.6 0.9 1.6 -1.3 -0.3
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.2 -0.4 -1.1
Medication: Amlodipine 0.3 0.4 0.5 -0.7 -0.6
Medication: Ventolin 100micrograms inhaler 2.8 3.6 3.6 1.9 1.9
Birth weight 0.2 0.4 0.7 0.0 -0.9
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 0.2 0.5
High blood pressure (siblings) 1.0 1.5 2.6 -1.6 -0.5
Forced vital capacity (FVC), Best measure 1.2 4.4 6.9 -2.6 -1.4
Body fat percentage 0.5 1.9 2.6 -1.6 1.1
Leg fat percentage (right) 0.6 2.0 3.3 -1.8 0.9
Arm fat-free mass (right) 0.1 0.5 0.8 0.3 0.9
Exposure to tobacco smoke outside home 0.8 1.0 2.0 -1.4 -0.2
Comparative body size at age 10 0.4 1.1 2.1 0.3 1.4
Number of full brothers 0.0 0.0 0.1 0.2 0.2
Worry too long after embarrassment 0.7 1.2 2.4 -0.3 -1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 0.5 0.7 0.5
Wheeze or whistling in the chest in last year 0.5 0.9 1.7 -0.4 1.3
Number of children fathered 0.2 0.2 0.5 0.7 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 1.6 -1.3 -0.9
Age at first live birth 1.6 2.9 4.5 -2.1 -1.1
Pulse wave peak to peak time 0.1 0.2 0.3 -0.1 0.6
Health satisfaction 1.6 2.1 2.3 1.3 1.5
Shortness of breath walking on level ground 0.3 0.3 0.6 -0.1 0.8
Qualifications: College or University degree 0.1 0.2 0.2 0.3 -0.5
Eye problems/disorders: None of the above 0.1 0.1 0.1 0.3 -0.2
Mouth/teeth dental problems: Loose teeth 3.0 3.6 5.6 -2.4 1.3
Emphysema/chronic bronchitis 1.4 1.5 2.7 0.6 1.6
Medication for pain relief, constipation, heartburn 0.6 1.1 1.9 1.4 -0.5
Neck or shoulder pain in last month 0.9 1.3 2.3 -1.5 0.5
Medication: Blood pressure 0.3 0.6 0.7 -0.7 -0.9
Angina (self-reported) 0.0 0.0 0.1 -0.0 -0.3
Migraine (self-reported) 1.1 1.3 2.4 -1.5 -0.6
Medication: Ibuprofen 1.2 1.4 1.5 -1.1 -1.2
Medication: Allopurinol 0.4 0.5 0.8 -0.9 -0.4
Medication: Omeprazole 0.1 0.1 0.2 -0.4 0.2
Medication: Seretide 50 evohaler 1.3 1.5 1.6 -1.2 1.3
Mean time to correctly identify matches 0.8 1.6 2.0 -1.1 -1.4
Heart disease (mother) 0.4 0.5 1.0 -0.1 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 -0.3 -0.4
Whole body fat mass 0.4 1.7 1.8 -1.2 1.3
Leg fat mass (right) 0.3 1.3 1.5 -1.1 1.2
Arm predicted mass (right) 0.2 0.8 1.5 -0.0 1.2
Pulse rate, automated reading 1.3 4.3 4.5 2.0 2.1
Alcohol intake frequency. 0.9 2.1 4.0 0.4 -2.0
Comparative height size at age 10 0.3 1.6 1.9 -1.4 -1.1
Number of full sisters 0.2 0.2 0.5 0.0 0.7
Suffer from ‘nerves’ 0.5 0.7 0.8 -0.9 -0.8
Overall health rating 0.8 1.7 2.9 -0.6 1.7
Chest pain or discomfort 0.4 0.5 0.7 0.8 0.6
Had major operations 2.1 2.5 4.0 2.0 1.0
Age at last live birth 9.8 14.2 20.4 -4.5 -2.8
Family relationship satisfaction 0.2 0.2 0.4 0.6 0.3
Leg pain on walking 0.0 0.0 0.1 0.0 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 0.8 -0.5 -0.9
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.7 -1.3 0.2
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.5 0.1 -1.2
Medication: Aspirin 0.0 0.0 0.0 0.0 -0.1
Supplements: Vitamin C 1.4 1.7 3.3 -1.8 -0.2
Knee pain experienced in last month 1.2 1.8 3.5 -1.9 -0.3
Hypertension (Self-reported) 0.5 1.4 1.9 -1.4 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.1 0.1 -0.3 0.1
Illnesses of father: Heart disease 0.9 1.3 2.3 -1.5 -0.6
Illnesses of siblings: Diabetes 1.4 1.7 2.2 1.5 1.1
Smoking status: Previous 0.4 0.5 1.0 -0.2 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.8 -0.2 -0.9
Whole body fat-free mass 0.1 0.6 1.1 0.2 1.1
Leg fat-free mass (right) 0.1 0.5 0.8 0.5 0.9
Arm fat percentage (left) 0.4 1.5 1.7 -1.3 1.1
Average weekly red wine intake 0.3 0.4 0.5 0.6 0.7
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.3 0.1 0.6
Mood swings 1.1 2.1 2.4 -1.3 1.5
Loneliness, isolation 0.5 0.7 1.3 -1.1 0.1
Long-standing illness, disability or infirmity 1.4 2.2 2.5 1.6 1.4
Ever had bowel cancer screening 0.1 0.1 0.1 0.2 -0.3
Diabetes diagnosed by doctor 0.2 0.4 0.6 0.7 0.5
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 0.2 0.0
Friendships satisfaction 0.5 0.6 1.0 -0.5 1.0
Qualifications: nursing, teaching 0.6 0.9 1.6 1.3 0.5
Commuting to job workplace: Walk 0.4 0.4 0.7 0.9 -0.3
Eye problems/disorders: Cataract 1.3 1.5 3.0 -0.2 -1.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.2 -0.3 -0.5
Medication for cholesterol 0.4 0.6 1.1 -0.2 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 1.7 0.7 1.3
Back pain experienced in last month 0.8 1.1 1.7 -0.7 1.3
Mineral and other dietary supplements 0.2 0.3 0.6 -0.1 -0.8
Breast cancer (self-reported) 0.1 0.1 0.1 -0.2 -0.3
Asthma (self-reported) 0.7 1.4 2.0 0.9 1.4
Osteoporosis (self-reported) 7.7 9.5 14.6 2.1 3.8
Osteoarthritis (self-reported) 0.6 0.7 1.3 -1.1 -0.4
Medication: Aspirin 0.2 0.2 0.4 0.7 0.0
Medication: Gliclazide 1.9 2.2 2.5 -1.6 -1.4
Illnesses of father: None of the above (group 1) 0.4 0.4 0.7 0.4 -0.8
Smoking status: Current 0.4 0.7 0.8 0.9 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.5 2.5 -1.6 -0.7
Whole body water mass 0.1 0.6 1.1 0.2 1.1
Leg predicted mass (right) 0.1 0.6 0.8 0.6 0.9
Arm fat mass (left) 0.4 1.7 2.2 -1.5 1.1
Number of self-reported non-cancer illnesses 0.3 0.6 0.8 -0.9 0.7
Average weekly champagne plus white wine intake 0.4 0.6 1.0 -0.3 1.0
Miserableness 0.4 0.7 1.4 0.1 1.2
Guilty feelings 0.0 0.0 0.0 -0.2 0.2
Wears glasses or contact lenses 0.2 0.2 0.3 0.3 0.5
Ever taken oral contraceptive pill 0.6 0.7 1.2 -1.1 -0.5
Hearing aid user 0.9 1.0 1.1 1.0 -0.9
Mother’s age at death 0.3 0.4 0.5 0.7 0.4
Financial situation satisfaction 0.3 0.3 0.4 0.6 -0.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.8 0.5 0.9
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.4 0.2
Eye problems/disorders: Glaucoma 0.4 0.5 0.9 -1.0 -0.1
Medication: Blood pressure 0.1 0.1 0.2 -0.5 0.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.2 -1.1 0.0
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.2 0.4 -0.4
High cholesterol (Self-reported) 0.8 1.4 2.7 -0.4 -1.6
Medication: Bendroflumethiazide 0.0 0.1 0.1 -0.4 0.1
Medication: Paracetamol 0.0 0.0 0.0 -0.1 0.2
Medication: Lisinopril 0.7 0.8 1.7 -0.1 -1.3
Medication: Atorvastatin 0.3 0.3 0.4 0.5 0.7
Illnesses of father: High blood pressure 0.6 0.8 1.2 -0.6 -1.1
Alcohol drinker status: Never 1.4 1.7 2.1 -1.2 -1.5
Ever smoked 0.7 1.2 2.1 0.6 1.4
Basal metabolic rate 0.1 0.6 1.2 -0.1 1.1
Leg fat percentage (left) 0.6 2.2 3.7 -1.9 0.8
Arm fat-free mass (left) 0.2 0.8 1.6 -0.3 1.2
Number of operations (self-reported) 0.5 0.8 1.4 1.2 0.4
Average weekly beer plus cider intake 0.6 0.9 1.0 -1.0 -0.9
Irritability 0.1 0.2 0.3 -0.3 0.6
Risk taking 1.9 2.7 4.8 -2.2 -0.8
Ever had prostate specific antigen (PSA) test 1.6 1.9 3.6 0.4 -1.9
Fractured/broken bones in last 5 years 1.4 1.9 2.1 1.3 1.5
Age started oral contraceptive pill 0.0 0.0 0.0 -0.1 0.1
Diastolic blood pressure, automated reading 1.1 3.5 4.3 -2.1 1.7
Ever depressed for a whole week 0.4 0.5 0.6 0.8 0.7
Unable to work because of sickness or disability 1.4 1.8 2.9 0.8 1.7
Commuting to job workplace: Cycle 0.1 0.2 0.3 0.2 0.5
Myopia 0.3 0.4 0.4 0.6 0.7
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.2 1.5 -0.4
Cholesterol lowering medication 0.3 0.5 0.7 0.9 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.0 0.1 0.1 -0.2 0.2
Pain experienced in last month 0.7 1.2 2.4 1.6 0.1
Supplements: Calcium 0.8 0.9 1.5 0.5 1.2
Basal cell carcinoma (self-reported) 2.4 2.9 4.2 2.1 1.3
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.7 -1.3 0.0
Deep venous thrombosis (DVT) (self-reported) 0.1 0.1 0.2 -0.5 0.2
Heart disease (siblings) 0.8 1.0 1.2 -1.1 -0.8
Alcohol drinker status: Previous 2.1 2.4 3.3 -1.8 -1.2
Pack years of smoking 0.2 0.3 0.4 -0.4 0.7
Impedance of whole body 0.1 0.6 1.0 -0.4 -1.0
Leg fat mass (left) 0.3 1.4 1.4 -1.2 1.1
Arm predicted mass (left) 0.1 0.6 1.2 -0.3 1.1