Hub : Genes

MAPRE2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Hippocampus	0.2814	0.0825	2.5e-04	-0.002	NA	0.017	NA	0.053	3.5e-01	NA	1.3e-01	NA	2.2e-02
2	GTEx	Cells Transformed fibroblasts	0.1600	0.0510	6.5e-05	0.046	NA	0.099	NA	0.067	2.1e-04	NA	7.7e-08	NA	8.8e-06
3	GTEx	Esophagus Gastroesophageal Junction	0.3370	0.1190	1.5e-03	-0.002	NA	0.043	NA	0.014	3.8e-01	NA	1.1e-02	NA	1.0e-01
4	NTR	Blood	0.0199	0.0073	7.5e-04	0.021	0.015	0.018	0.02	0.020	1.6e-07	1.1e-05	1.0e-06	2.7e-07	2.4e-07
5	TCGA	Cervical Squamous Cell Carcinoma	0.1080	0.0470	3.4e-03	0.079	0.017	0.049	NA	0.054	1.1e-04	4.7e-02	1.9e-03	NA	1.2e-03
6	TCGA	Brain Lower Grade Glioma	0.0532	0.0255	3.0e-03	-0.001	0.013	0.000	NA	-0.001	5.2e-01	1.1e-02	3.3e-01	NA	3.9e-01
7	TCGA	Liver Hepatocellular Carcinoma	0.0570	0.0310	6.6e-03	0.017	0.053	0.028	NA	0.028	5.1e-02	1.7e-03	1.7e-02	NA	1.8e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.9	3.1	10.4	0.8	-3.2	0.9	-0.7	-2.9	-0.9	-0.5
Bipolar Disorder or Schizophrenia	0.7	1.8	6.8	0.6	-2.6	0.4	-1.0	-1.9	0.4	0.6
Depressed Affect (Nagel 2018)	0.7	1.5	3.7	-0.6	-1.7	0.4	1.4	-1.1	0.4	-1.9
Depression (Nagel 2018)	0.4	0.6	1.6	1.3	0.2	-0.5	-1.0	0.5	0.8	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.0	-0.7	0.6	1.0	0.8	0.4	0.7	-0.6
Neuroticism (Nagel 2018)	0.4	1.1	2.9	0.1	-1.7	0.4	0.2	-1.3	-0.6	-1.5
Schizophrenia (2018)	0.3	0.6	1.5	0.2	-0.8	-0.1	-0.7	-0.1	1.2	1.2
Schizophrenia vs Biploar Disorder	0.3	0.3	2.0	0.0	0.4	-1.4	0.1	0.4	0.2	-0.0
Worry (Nagel 2018)	1.1	2.2	5.0	0.3	-2.2	-0.3	-0.3	-2.0	-1.8	-1.8
Alzheimer’s Disease (in mother)	0.7	0.9	2.2	-1.5	-0.0	0.5	0.8	0.1	-0.9	-1.5
Alzheimer’s Disease (in father)	0.4	0.5	1.0	0.6	0.6	-0.8	-0.5	0.1	-0.7	1.0
Alzheimer’s Disease (including proxy)	0.5	0.7	2.5	0.5	-0.5	-1.1	-0.8	-0.6	-1.6	0.2
Crohns Disease (2017)	0.1	0.3	1.1	0.1	0.0	-1.0	-0.4	-0.2	-0.7	-0.4
Irritable Bowel Disease (IBD)	0.3	0.7	1.6	-0.0	1.2	-1.0	-0.8	0.8	-1.0	0.4
Ulcerative Colitis (UC)	0.5	1.0	3.6	-0.5	1.9	-0.6	-0.5	1.2	-0.7	0.7
Major Depression (MDD)	0.2	0.2	0.7	0.2	-0.3	-0.6	-0.8	-0.2	-0.6	-0.4
Reaction Time	0.9	1.6	5.1	0.8	1.0	-0.9	0.2	1.1	2.3	1.6
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	0.5	0.9	0.4	0.3	0.7	1.0	0.3
Breast Cancer	2.2	5.3	11.8	-3.4	1.3	2.5	2.6	2.1	1.7	-1.9
Ovarian Cancer	1.4	1.8	3.5	-1.2	-1.7	0.8	1.5	-1.3	0.7	-1.9
Prostate Cancer	1.3	1.9	4.4	-1.4	0.5	2.1	1.7	1.3	0.1	-1.4
Age at First Birth	0.6	0.9	2.4	-0.4	-1.0	-0.2	0.9	-0.1	-1.6	-1.5
Bipolar Disorder (2011)	0.5	0.5	0.9	-0.0	-1.0	0.9	0.8	-0.9	-0.5	-0.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	-1.1	0.7	-0.1	-0.0	0.4	-0.7	-0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.7	0.3	-1.0	-0.2	-0.1	-1.1	1.6	0.3
Crohns Disease (2012)	0.2	0.4	1.7	-0.2	-0.1	0.3	-0.8	-0.4	-1.3	-0.2
Mean Putamen Volume	1.3	1.5	4.7	0.2	1.4	0.2	1.6	1.2	2.2	0.3
Fasting Glucose	1.3	1.6	3.8	0.1	-1.3	1.9	-0.7	-1.0	2.0	-0.5
HbA1C	1.2	1.3	2.6	0.7	-1.6	0.4	-1.4	-1.5	1.2	0.3
HDL Cholesterol	0.6	1.0	2.4	1.0	-0.4	-0.9	-1.1	-1.2	0.2	1.6
LDL Cholesterol	0.7	1.1	3.6	0.8	-0.5	0.9	-1.9	-0.1	-1.2	1.0
Lupus	0.6	0.9	1.6	-1.1	1.3	-1.1	-0.3	0.9	-0.9	-0.6
Neuroticism (2016)	0.3	0.4	1.3	0.3	-0.3	1.0	-0.2	-0.0	-1.1	-0.5
Primary Biliary Cirrhosis	0.2	0.2	0.7	-0.8	0.2	0.5	0.6	-0.1	-0.5	-0.1
Rheumatoid Arthritis	0.5	0.7	2.8	-0.2	-0.4	-0.6	0.5	-0.3	-1.7	-1.0
Schizophrenia (2014)	0.3	0.6	2.3	0.0	-1.5	-0.2	-0.8	-0.8	0.4	0.5
Triglycerides	0.6	1.0	3.7	-1.0	-0.7	0.9	0.3	-0.1	-0.9	-1.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.2	-0.1	-1.0	0.7	0.3	-1.0	0.5	-1.5
Ulcerative Colitis	1.1	1.6	3.2	0.6	1.4	-0.5	-1.8	0.7	-1.6	1.5
Blood Eosinophil Count	0.1	1.1	2.3	-0.2	1.5	0.3	1.4	1.4	0.9	0.8
Blood Platelet Count	0.2	2.7	10.0	0.8	-2.7	0.5	0.4	-3.2	0.8	0.0
Blood Red Count	0.3	2.9	5.3	-1.6	2.2	-0.4	1.5	2.3	2.3	0.5
Blood White Count	0.2	1.4	7.3	-0.1	-0.7	2.7	1.0	-0.8	0.5	-0.2
Heel T-Score	0.5	4.2	26.0	0.4	-1.4	-5.1	-0.2	-1.0	0.7	-0.3
BMI	0.4	2.4	6.6	-1.0	2.6	1.1	-0.5	1.9	1.1	1.7
Height	0.1	2.4	5.9	1.2	1.8	0.7	-0.6	0.8	-2.2	2.4
Waist Hip Ratio (WHR)	0.2	0.8	1.7	0.4	1.3	-0.5	-0.6	1.2	-0.5	1.3
Systolic Blood Pressure	0.3	1.7	6.4	0.3	-2.5	0.2	0.7	-1.9	0.3	-1.1
Smoking Status	0.1	0.3	1.5	-0.1	0.0	0.1	0.4	0.3	-1.2	-0.7
Allergy or Eczema	0.6	1.5	2.8	0.5	-1.4	-1.7	1.7	-1.2	0.6	-0.7
Cardiovascular Disease	0.1	0.3	1.2	0.2	-1.1	-0.0	0.0	-0.9	-0.3	0.0
Hypothyroidism (self reported)	0.3	0.8	2.1	0.8	1.0	-1.4	-0.8	0.4	-0.6	0.8
Respiratory disease	0.2	0.5	1.1	1.0	-1.0	0.4	-0.3	-0.9	0.5	-0.1
Type 2 Diabetes (T2D) (2018)	1.1	2.1	4.9	-0.7	2.2	1.0	1.3	2.0	1.5	0.5
Lung FEV1/FVC ratio	1.8	8.9	21.5	-3.2	4.6	-1.2	2.2	4.6	1.8	-0.5
Lung FVC	0.3	1.5	3.7	0.4	1.4	-1.9	-0.4	1.6	-0.4	1.4
Neuroticism	0.9	2.1	6.2	0.4	-2.5	0.1	-0.3	-1.9	-1.5	-1.4
Chronotype (morning person)	1.2	2.7	6.1	0.5	-2.5	2.4	-1.1	-1.7	-1.7	-0.3
Hair Pigment	0.0	0.3	1.5	-0.0	-0.3	-0.3	0.6	0.1	1.2	-0.4
Tanning	0.2	2.3	5.1	-0.3	2.3	1.0	-1.0	2.1	0.8	1.9
Hand grip strength (left)	1.2	3.0	7.6	-2.2	2.8	0.0	1.2	2.8	-0.1	-0.3
Number of treatments/medications taken	0.7	1.2	3.0	0.5	-1.7	-0.7	0.8	-1.5	-1.2	-0.6
Average weekly spirits intake	1.3	1.6	2.9	-1.5	1.2	0.2	1.6	1.3	-0.6	-1.7
Sensitivity / hurt feelings	1.0	1.7	4.7	-0.2	2.2	1.2	-0.6	2.0	-0.8	0.8
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	0.6	-0.4	-0.5	-0.8	-0.2	-0.1	-0.1
Hearing difficulty/problems: Yes	0.5	0.7	1.1	0.8	-0.8	-0.8	1.0	-1.0	-0.6	-0.8
Relative age of first facial hair	0.3	0.7	1.0	0.9	-0.8	-1.0	-1.0	-1.0	-0.8	-0.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.3	1.6	0.3	-1.0	0.3	-0.3	1.9	2.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	-0.6	0.4	0.5	1.0	0.8	0.4	-0.4
Ever had hysterectomy (womb removed)	3.6	4.0	7.0	-2.2	1.8	2.0	1.5	2.6	2.0	-1.5
Systolic blood pressure, automated reading	0.2	0.6	2.0	0.3	-1.4	-0.6	0.0	-0.9	0.7	-0.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.0	0.1	0.5	0.1	-0.6	0.8	1.4	-0.0
Angina	0.8	1.0	2.3	1.4	-0.9	0.8	-0.6	-1.5	0.8	0.5
Medication for hormone replacement therapy	0.7	0.8	3.9	0.6	0.1	-0.5	-1.0	-0.2	-2.0	0.3
Vitamin and mineral supplements	0.7	1.0	1.9	-1.0	-0.4	0.7	1.4	-0.8	1.1	-1.3
Supplements: Zinc	0.2	0.3	0.7	-0.2	-0.8	0.7	0.2	-0.3	0.1	-0.7
Medication: Co-codamol	1.0	1.1	2.8	-1.2	0.4	1.7	1.6	0.5	0.8	-0.4
Medication: Metformin	1.2	1.7	4.2	-0.7	1.5	0.4	2.1	1.3	1.7	-0.1
Diabetes (father)	0.8	1.0	2.3	-0.2	0.8	1.2	1.5	0.6	1.5	0.3
Diabetes (mother)	0.3	0.4	1.1	-1.1	-0.4	-0.2	0.9	-0.1	-0.2	-0.9
Severe depression (siblings)	1.3	1.5	3.8	-1.9	1.7	0.0	1.1	1.5	-0.1	-0.4
Pack years adult smoking proportion	0.3	0.4	1.3	-0.6	0.4	-0.5	1.1	0.7	-0.7	-0.0
Impedance of leg (right)	1.0	4.6	15.9	-0.2	-4.0	0.7	0.9	-2.8	1.0	-2.4
Leg fat-free mass (left)	0.9	4.6	15.6	-0.4	4.0	-0.1	-0.7	2.9	-0.4	2.6
Trunk fat percentage	0.2	0.8	2.3	-1.5	0.7	0.7	0.8	0.6	1.2	-0.4
Hand grip strength (right)	0.8	2.2	5.8	-2.0	2.4	-0.0	0.4	2.4	-0.1	-0.2
Townsend deprivation index at recruitment	1.4	1.9	5.0	-1.3	0.2	0.4	2.2	1.5	1.0	-1.8
Current tobacco smoking	0.3	0.4	0.7	0.7	0.8	0.6	0.3	0.8	-0.1	0.8
Average weekly fortified wine intake	1.4	1.6	4.3	0.7	-2.0	-1.2	0.0	-2.1	-1.0	-0.0
Maternal smoking around birth	0.3	0.4	1.1	-0.5	0.0	0.3	1.0	-0.0	-0.3	-1.1
Fed-up feelings	0.3	0.6	1.6	0.1	-1.3	0.6	0.2	-1.1	-0.6	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.4	2.9	1.4	1.2	-0.0	-0.6	1.7	1.4	1.1
Relative age voice broke	0.3	0.4	0.9	0.6	-1.0	0.2	0.5	-0.2	-0.3	-1.0
Taking other prescription medications	0.2	0.3	0.8	0.0	-0.9	-0.7	0.2	-0.8	-0.3	-0.4
Age when periods started (menarche)	1.1	2.6	4.7	-1.8	2.2	2.1	0.9	2.0	1.1	0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	-0.3	0.4	0.7	0.8	1.2	0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.8	-1.7	-0.4	-1.5	0.9	-0.7	-0.4	-2.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	3.2	-0.1	1.3	-1.2	0.6	1.4	1.8	0.4
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.6	-0.2	0.1	0.2	-0.3	-0.3	0.0
Serious illness, injury or assault to yourself	0.4	0.5	1.3	0.1	0.7	-0.4	0.5	0.9	1.1	-0.4
High blood pressure	0.2	0.6	1.2	-1.1	-0.7	0.5	0.6	-0.6	-0.3	-1.1
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	0.4	-0.7	-1.3	0.8	-0.6	0.4	-0.2
Multivitamins +/- minerals	1.5	2.0	5.5	1.7	0.2	-0.3	-1.9	-0.3	-1.2	2.3
Stomach or abdominal pain in last month	0.6	0.8	3.2	0.7	-0.4	0.4	1.2	-0.1	1.8	-0.2
Supplements: Glucosamine	0.5	0.6	2.7	-0.3	-0.0	-1.6	1.1	0.2	-0.4	0.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	0.8	-0.7	-0.1	-0.0	-0.9	0.8	0.4
Medication: Atenolol	1.5	1.8	4.6	-1.6	-0.1	0.2	2.1	0.6	0.9	-2.1
Medication: Levothyroxine sodium	1.4	2.4	6.2	-2.0	2.5	0.8	1.2	1.9	-0.1	-0.6
Sitting height	0.4	3.0	12.3	-1.3	-0.3	3.5	0.5	-0.1	-2.4	-1.2
Chronic bronchitis/emphysema (father)	0.9	1.1	3.2	-1.0	1.6	-0.2	0.7	1.8	-0.6	-0.5
High blood pressure (mother)	0.3	0.4	1.1	-0.2	1.0	-0.6	-0.1	1.0	0.2	-0.6
Body mass index (BMI)	0.8	3.5	11.4	-1.1	3.4	0.3	0.4	2.6	1.5	1.5
Impedance of leg (left)	1.2	5.9	20.7	-0.0	-4.6	1.1	0.8	-3.3	0.1	-2.8
Leg predicted mass (left)	0.9	4.9	16.4	-0.4	4.0	-0.1	-0.9	3.0	-0.4	2.8
Trunk fat mass	0.3	1.1	3.0	-1.2	1.7	0.6	0.5	1.3	0.9	0.5
Waist circumference	0.5	1.7	5.7	-0.9	2.4	0.9	-0.2	1.7	0.2	1.3
Number of incorrect matches in round	0.9	1.6	6.3	-0.3	-0.7	2.5	0.4	-1.2	1.5	-0.4
Past tobacco smoking	0.7	1.4	3.9	0.9	1.2	-0.7	-0.4	0.7	1.5	2.0
Alcohol usually taken with meals	1.3	2.2	6.9	0.0	-2.4	0.1	0.3	-2.6	-0.8	-1.2
Nervous feelings	1.4	2.6	4.7	1.1	-2.0	-1.0	-1.8	-1.9	-2.2	-0.6
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	6.3	2.5	-0.4	-0.8	-2.4	-0.1	-0.6	1.9
Hearing difficulty/problems with background noise	0.9	1.4	2.8	0.1	-1.7	-1.1	0.5	-1.5	-1.3	-1.1
Hair/balding pattern: Pattern 2	1.2	1.6	2.7	-1.0	-1.7	1.3	1.6	-1.3	-0.2	-1.1
Had menopause	0.1	0.2	0.3	0.4	-0.5	-0.5	-0.1	-0.2	0.6	0.3
Had other major operations	1.4	1.7	9.8	0.4	-0.9	-3.1	-0.4	-0.8	-0.7	0.1
Forced vital capacity (FVC)	0.1	0.5	0.8	0.2	0.7	-0.8	-0.4	0.8	-0.6	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.8	-1.6	-0.2	-1.7	1.1	-0.7	-0.5	-2.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	-1.0	0.3	-0.4	0.4	0.4	-0.4	-0.8
Qualifications: None of the above	0.1	0.2	0.6	-0.3	0.0	-0.4	0.5	0.0	-0.7	-0.8
Financial difficulties in last 2 years	1.7	2.2	5.3	0.3	2.3	1.5	0.0	2.3	1.4	0.9
Mouth/teeth dental problems	0.2	0.3	1.4	-0.3	-0.0	0.1	0.4	-0.0	1.2	0.6
Heart attack	0.6	0.7	3.3	-0.2	0.4	0.7	0.9	-0.4	1.8	0.1
Allergy	0.2	0.5	1.0	-0.7	1.0	0.9	-0.2	0.8	-0.1	0.4
Pain all over the body in last month	0.5	0.6	1.4	0.9	-1.2	0.3	0.7	-1.0	0.3	-0.1
Diabetes (self-reported)	0.5	0.7	2.3	-0.2	1.0	0.8	0.6	0.7	1.5	0.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.8	0.9	-0.9	-0.5	-0.6	0.1	-0.6	0.5
Medication: Ramipril	0.3	0.4	0.8	-0.7	0.9	-0.1	0.8	0.5	-0.7	-0.6
Medication: Simvastatin	0.7	1.1	2.3	0.1	-1.5	-0.5	0.6	-1.4	-1.1	-1.2
Fluid intelligence score	0.2	0.4	0.8	0.8	-0.5	-0.9	-0.1	-0.8	-0.1	0.1
Illnesses of siblings	0.7	1.0	2.6	0.8	0.7	-0.7	-1.4	0.7	0.2	1.6
Neuroticism score	0.2	0.5	1.3	0.3	-1.2	0.4	-0.2	-0.9	-0.8	-0.7
Weight	0.6	2.7	9.5	-0.7	3.1	0.6	-0.0	2.2	0.4	1.9
Impedance of arm (right)	1.2	5.6	18.2	-0.4	-4.3	0.7	1.2	-2.8	0.8	-3.2
Arm fat percentage (right)	0.4	1.6	3.0	-1.4	1.7	0.5	1.0	1.4	1.7	0.2
Trunk fat-free mass	0.9	5.0	13.8	0.9	3.7	-0.1	-1.1	2.8	-0.7	3.3
Hip circumference	0.3	1.5	5.3	-0.8	2.3	1.0	-0.5	1.4	-0.1	1.2
Time employed in main current job	1.3	1.5	3.4	-0.9	-1.0	1.8	1.0	-1.2	1.4	-1.0
Alcohol intake versus 10 years previously	0.8	1.2	3.1	-0.5	1.8	-1.3	0.3	1.5	0.6	0.9
Father’s age at death	3.8	5.1	14.1	1.1	-3.7	-1.6	-0.8	-3.8	-1.8	-0.5
Worrier / anxious feelings	0.5	0.9	2.9	0.6	-1.7	0.3	-0.1	-1.5	0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.3	1.0	0.9	-0.5	0.4	1.1	0.7	0.5
Falls in the last year	0.5	0.7	2.1	1.0	-1.5	-0.7	-0.0	-0.9	0.6	-0.7
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	-0.1	0.3	-0.7	-0.5	0.1	-0.9	-0.4
Number of live births	0.3	0.4	1.0	0.8	0.4	-0.6	-0.6	0.6	0.1	1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	5.2	-0.9	2.2	-0.9	0.2	2.3	-0.1	0.7
Pulse rate	0.3	0.5	1.0	0.3	0.8	-0.7	-1.0	0.8	-0.6	0.2
Happiness	0.7	0.9	2.0	-0.3	-1.4	1.1	-0.0	-1.2	0.9	-0.7
Noisy workplace	0.6	0.8	2.9	-0.8	0.7	0.5	0.9	0.7	1.7	-0.1
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.3	0.9	-2.3	0.5	-0.3	-1.9	0.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.1	0.1	-0.6	1.5	-0.2	-0.0	0.9	0.9
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.1	-0.4	0.5	0.2	-0.2	-0.3	-0.3
Asthma	0.3	0.6	1.7	0.9	-1.3	-0.2	-0.4	-1.2	0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-0.5	0.7	0.5	0.3	0.4	0.4	1.0
Medication: Cholesterol lowering	0.3	0.5	0.9	0.6	-0.9	0.5	0.0	-0.8	-0.9	-0.7
Depression (self-reported)	0.6	0.7	1.9	-0.6	-0.3	0.5	1.4	-0.6	0.6	-1.3
Medication: Lansoprazole	0.7	0.7	3.3	-0.0	-0.7	1.8	0.5	-0.6	0.9	-0.4
Prospective memory result	0.5	0.6	1.2	0.9	-0.9	-0.1	-0.5	-1.1	0.9	-0.2
Lung cancer (father)	3.5	4.1	12.7	0.2	3.6	-0.3	-0.7	3.1	0.4	2.4
Illnesses of mother	0.4	0.4	1.8	0.1	-0.7	1.4	0.0	-0.7	-0.2	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	6.0	-0.5	2.3	-0.5	0.4	2.5	0.7	1.3
Pulse wave Arterial Stiffness index	3.9	4.5	9.3	3.1	0.1	-2.6	-2.6	-0.3	-1.1	2.7
Impedance of arm (left)	1.6	7.5	25.9	-0.2	-5.1	0.6	0.9	-3.6	0.5	-3.4
Arm fat mass (right)	0.5	2.2	6.3	-1.2	2.5	0.9	0.4	2.0	1.3	1.1
Trunk predicted mass	0.9	4.9	13.8	0.9	3.7	-0.1	-1.0	2.8	-0.7	3.3
Standing height	0.1	1.3	5.0	0.9	-0.2	0.6	-1.0	-0.3	-2.2	1.2
Length of working week for main job	1.2	1.4	2.5	1.1	1.5	0.1	-0.2	1.1	1.5	1.6
Exposure to tobacco smoke at home	1.1	1.3	2.2	-1.0	-0.1	1.5	1.5	0.5	1.3	-1.3
Breastfed as a baby	3.6	4.4	10.7	1.5	-0.6	-2.7	-2.3	-1.5	-3.3	1.7
Tense / ‘highly strung’	0.7	1.2	4.1	0.9	-0.8	-1.4	-0.7	-0.6	-2.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.0	-0.4	-0.2	-0.5	0.6	0.6	-1.0	-2.0
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	-0.6	1.1	0.6	-1.0	0.9	0.3	0.6
Birth weight of first child	1.4	2.5	6.4	-1.6	2.4	0.9	0.2	2.5	1.0	-0.9
Peak expiratory flow (PEF)	1.8	4.1	11.6	-1.9	3.4	0.5	0.6	3.4	1.1	0.4
Pulse wave reflection index	2.4	2.9	7.8	2.4	0.5	-2.2	-1.3	-0.4	-0.2	2.8
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.7	-0.9	1.2	1.9	0.1	1.6	1.1	-0.4
Loud music exposure frequency	0.6	0.7	1.7	-0.8	0.6	-0.4	0.8	1.3	-0.2	-1.1
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.9	1.4	-0.9	0.4	-0.3	-0.7	2.0	1.3
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	4.4	1.4	0.1	-1.7	-2.1	-0.1	-1.9	0.6
Blood clot in the leg (DVT)	1.3	1.6	4.5	0.7	1.2	-2.1	-0.8	1.4	-1.4	0.7
Medication: Paracetamol	0.5	0.8	3.7	0.5	-0.7	-0.5	-0.2	-0.7	-1.9	0.2
Headache pain in last month	2.8	4.8	11.1	2.5	-1.1	-3.3	-2.6	-2.2	-0.4	1.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	3.0	-0.4	1.7	-0.9	0.3	1.7	1.5	1.0
Glaucoma (self-reported)	2.2	2.5	4.0	-1.9	-1.6	1.4	1.3	-1.2	-1.6	-2.0
Gout (self-reported)	0.5	0.7	2.7	-0.2	-0.4	-1.6	-0.6	-0.2	-1.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	-0.3	1.1	-1.5	-0.1	0.5	-1.3	0.2
Medication: Amlodipine	0.4	0.5	1.2	-0.6	-0.7	0.3	1.1	-0.6	0.1	-0.9
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.9	-0.5	-1.4	-0.7	0.8	-0.4	-0.2	-1.1
Birth weight	0.6	1.3	3.2	0.9	0.7	-0.5	-1.8	0.1	-1.2	1.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	0.7	-0.3	0.5	0.4	-0.2	-0.9	-0.4
High blood pressure (siblings)	1.1	1.5	2.8	-0.9	-1.3	1.5	1.3	-1.2	0.1	-1.7
Forced vital capacity (FVC), Best measure	0.1	0.4	1.6	0.3	0.5	-0.6	-0.2	0.7	0.1	1.3
Body fat percentage	0.2	0.8	1.9	-1.3	0.8	0.7	0.9	0.6	1.4	-0.1
Leg fat percentage (right)	0.5	1.8	4.0	-1.4	1.6	0.7	1.4	1.1	2.0	0.2
Arm fat-free mass (right)	0.9	4.9	14.1	0.5	3.8	-0.2	-1.3	2.5	-0.7	3.4
Exposure to tobacco smoke outside home	0.3	0.4	1.7	-0.2	0.4	1.3	0.0	0.6	0.3	-0.3
Comparative body size at age 10	0.6	1.8	3.4	0.1	1.8	-0.3	-1.7	0.7	-1.6	1.8
Number of full brothers	2.0	2.5	5.6	1.6	0.5	-2.4	-1.3	0.2	-2.3	1.4
Worry too long after embarrassment	1.0	1.6	4.8	-0.2	-1.9	1.3	-0.1	-2.2	-0.5	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	3.9	0.2	-2.0	0.3	0.5	-1.4	-1.1	-1.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.6	0.8	-0.1	0.1	-0.0	-0.1	0.1	0.1
Number of children fathered	1.3	1.5	3.0	1.4	1.7	-1.2	-0.3	0.9	0.4	1.7
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	8.3	-0.8	-2.9	-0.6	0.7	-2.1	-2.0	-2.6
Age at first live birth	0.8	1.5	4.6	-0.2	-1.4	-1.1	-0.9	-0.8	-2.1	-1.1
Pulse wave peak to peak time	3.5	4.2	8.2	-2.9	-0.1	2.6	2.5	0.2	1.0	-2.5
Health satisfaction	0.3	0.4	1.1	1.1	-0.7	0.5	-0.6	-0.6	0.5	0.4
Shortness of breath walking on level ground	0.6	0.8	1.9	1.1	1.4	-0.2	-0.2	0.5	-0.3	1.3
Qualifications: College or University degree	0.6	1.8	6.9	0.5	-2.6	-0.2	0.2	-2.2	0.4	-0.9
Eye problems/disorders: None of the above	0.8	0.9	3.4	-0.8	-0.8	1.8	0.8	-0.1	0.4	-1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.2	0.5	-0.7	-0.1	-0.5	-0.5	0.3
Emphysema/chronic bronchitis	0.5	0.5	2.3	0.1	-0.7	1.5	-0.2	-0.4	0.5	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	1.5	0.6	0.2	-0.7	-1.2	0.1	-0.0	0.7
Neck or shoulder pain in last month	1.1	1.6	6.0	1.3	-1.3	0.0	-2.5	-1.2	-0.4	0.5
Medication: Blood pressure	0.4	0.8	2.3	-0.2	-1.0	0.6	-0.0	-1.5	-0.9	-0.9
Angina (self-reported)	0.7	1.0	2.5	1.3	-1.1	0.8	-0.4	-1.6	0.6	0.3
Migraine (self-reported)	0.3	0.3	0.8	-0.5	0.2	0.9	0.5	0.8	0.4	-0.2
Medication: Ibuprofen	0.2	0.2	1.1	0.3	0.3	0.4	0.2	-0.3	0.4	1.0
Medication: Allopurinol	0.8	1.1	3.9	0.3	-0.5	-2.0	-0.6	-0.5	-1.6	-0.2
Medication: Omeprazole	0.5	0.6	1.6	0.4	-0.8	1.2	0.4	-1.3	-0.0	-0.4
Medication: Seretide 50 evohaler	1.5	1.7	3.6	1.8	-1.9	-1.0	-1.0	-1.8	0.4	0.5
Mean time to correctly identify matches	0.5	0.9	3.6	0.6	0.4	-0.7	0.2	0.6	1.9	1.1
Heart disease (mother)	0.3	0.4	0.8	-0.9	0.3	-0.5	0.6	-0.4	0.6	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.8	0.2	-0.4	-0.3	-0.7	-0.3	0.9	-0.0
Whole body fat mass	0.4	1.5	4.3	-1.2	2.1	0.7	0.4	1.6	1.0	0.9
Leg fat mass (right)	0.6	2.1	5.7	-1.4	2.4	0.7	0.9	1.8	1.4	0.9
Arm predicted mass (right)	1.0	5.0	15.2	0.1	3.9	0.1	-1.0	2.9	-0.7	3.1
Pulse rate, automated reading	0.1	0.4	1.3	-0.6	-0.3	0.5	0.5	-0.6	-1.1	-0.6
Alcohol intake frequency.	0.6	1.4	3.4	1.3	1.6	-1.0	-0.0	1.2	0.1	1.8
Comparative height size at age 10	0.7	4.1	7.3	2.2	0.2	-2.1	-2.1	-1.0	-2.7	2.5
Number of full sisters	1.0	1.2	3.0	-0.9	1.7	1.3	1.1	1.4	-0.1	0.1
Suffer from ‘nerves’	1.1	1.7	6.4	0.9	-1.1	-0.6	-1.0	-1.2	-2.5	-0.7
Overall health rating	0.5	1.0	3.0	0.4	-0.9	1.7	1.1	-0.8	0.8	-0.8
Chest pain or discomfort	1.6	2.3	6.6	1.3	-2.6	-0.7	-0.4	-2.2	-0.5	-1.5
Had major operations	0.5	0.6	2.1	-0.1	-0.4	-1.2	-0.2	-0.6	-1.4	-0.0
Age at last live birth	0.8	1.2	4.5	0.3	-0.9	-1.1	-1.1	-0.6	-2.1	-0.2
Family relationship satisfaction	0.1	0.1	0.2	0.3	-0.4	0.2	0.3	-0.4	0.3	0.4
Leg pain on walking	2.3	2.9	6.6	2.0	-1.0	-2.6	-1.3	-1.3	-1.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	3.5	0.2	1.1	-1.9	-0.3	0.3	0.2	0.3
Commuting to job workplace: Car/motor vehicle	2.4	2.8	6.4	2.5	1.0	-1.0	-2.2	0.3	0.2	2.5
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	4.5	-1.3	-2.1	-1.0	1.1	-1.5	-1.0	-2.1
Medication: Aspirin	1.0	1.3	4.1	-0.6	0.7	0.6	2.0	1.1	1.3	-0.9
Supplements: Vitamin C	0.8	0.9	3.2	-0.5	-1.0	1.2	0.6	-0.2	-0.4	-1.8
Knee pain experienced in last month	1.1	1.7	3.3	1.1	-1.8	-1.6	-0.8	-1.1	-1.7	0.4
Hypertension (Self-reported)	0.3	0.9	2.0	-1.3	-0.9	0.3	1.0	-0.7	-0.3	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	2.3	-0.1	-0.8	1.5	1.5	-0.6	1.4	-0.9
Illnesses of father: Heart disease	1.9	2.6	7.3	-2.1	-0.5	1.1	2.7	-0.3	1.1	-1.9
Illnesses of siblings: Diabetes	0.4	0.5	1.8	-0.2	1.3	0.2	1.0	0.8	0.0	0.3
Smoking status: Previous	0.8	1.2	3.6	-1.2	-0.8	1.0	0.9	-0.4	-0.9	-1.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	5.2	-0.1	0.1	2.3	0.3	-0.0	0.7	0.7
Whole body fat-free mass	0.9	5.4	16.4	0.4	4.0	-0.1	-1.1	3.0	-0.6	3.3
Leg fat-free mass (right)	0.9	4.7	15.1	-0.1	3.9	-0.0	-1.1	2.8	-0.9	2.8
Arm fat percentage (left)	0.3	1.0	3.0	-1.1	1.2	0.3	0.8	0.9	1.7	0.3
Average weekly red wine intake	0.7	1.0	3.1	-1.1	-0.1	0.9	1.8	-0.0	0.8	-1.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.7	0.3	0.3	0.4	0.4	0.1	0.8	0.4
Mood swings	0.1	0.1	0.3	0.5	-0.3	-0.3	-0.3	-0.3	0.1	-0.6
Loneliness, isolation	1.1	1.5	2.9	-0.5	-1.7	0.8	0.9	-1.1	-1.5	-1.6
Long-standing illness, disability or infirmity	0.6	0.9	3.3	-0.5	-0.9	-0.0	1.8	-1.0	0.6	-1.0
Ever had bowel cancer screening	1.4	1.7	4.9	-0.0	-2.2	0.0	0.2	-2.0	-0.5	-1.6
Diabetes diagnosed by doctor	0.6	0.9	2.7	-0.4	1.3	0.4	0.7	0.9	1.6	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	1.3	-0.2	-0.7	-0.7	0.4	1.2	0.3
Friendships satisfaction	0.8	1.0	2.6	0.5	-1.6	0.8	0.4	-1.3	-0.8	-0.9
Qualifications: nursing, teaching	0.1	0.1	0.4	0.2	-0.6	0.4	0.0	-0.3	0.3	0.4
Commuting to job workplace: Walk	1.4	1.5	4.4	-0.7	-1.5	2.1	0.4	-1.3	0.2	-1.3
Eye problems/disorders: Cataract	0.8	0.9	2.5	1.2	0.3	-1.6	-0.5	-0.7	-0.7	1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.9	-0.7	-0.3	0.1	1.5	-0.3	1.1	-1.7
Medication for cholesterol	0.2	0.2	0.7	-0.1	0.2	0.8	0.1	0.6	-0.3	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.3	1.5	-1.0	-1.2	-1.2	-0.9	-0.1	0.5
Back pain experienced in last month	1.4	2.0	5.7	2.4	-0.6	-0.9	-2.0	-0.8	0.0	1.6
Mineral and other dietary supplements	0.6	0.8	3.2	0.2	-0.0	1.8	-1.2	-0.3	0.9	-0.1
Breast cancer (self-reported)	0.8	1.0	2.3	1.5	0.2	-1.4	-0.9	-0.4	-1.0	0.8
Asthma (self-reported)	0.4	0.8	2.0	1.1	-1.4	-0.4	-0.7	-1.4	-0.0	-0.0
Osteoporosis (self-reported)	0.4	0.5	1.7	1.3	0.6	-0.4	-0.2	0.6	0.5	1.0
Osteoarthritis (self-reported)	1.1	1.5	4.0	1.3	-1.6	-2.0	-0.4	-1.2	-0.8	0.1
Medication: Aspirin	0.7	0.9	3.1	-0.4	0.4	0.5	1.8	0.7	1.1	-0.9
Medication: Gliclazide	1.7	1.9	4.4	-0.7	1.9	1.5	0.6	1.6	2.1	-0.1
Illnesses of father: None of the above (group 1)	0.6	0.7	2.7	1.1	0.1	-0.2	-1.7	0.1	-0.8	0.7
Smoking status: Current	0.2	0.3	0.8	0.9	0.3	0.2	-0.1	0.5	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	6.1	-1.3	2.5	-0.7	0.6	2.2	-0.5	0.3
Whole body water mass	1.0	5.6	17.1	0.4	4.1	-0.2	-1.1	3.0	-0.7	3.3
Leg predicted mass (right)	0.9	4.7	15.1	-0.1	3.9	-0.0	-1.1	2.8	-0.9	2.8
Arm fat mass (left)	0.4	1.7	5.1	-1.1	2.2	0.5	0.4	1.7	1.2	1.0
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	0.7	-1.0	-0.5	-0.0	-0.4	-0.2	0.7
Average weekly champagne plus white wine intake	0.2	0.3	0.8	0.0	0.1	-0.8	-0.9	-0.3	-0.3	0.3
Miserableness	0.5	0.8	2.1	-0.7	-1.0	0.5	1.0	-0.9	-0.2	-1.4
Guilty feelings	0.2	0.3	1.0	0.0	-0.0	-1.0	0.0	0.2	-0.9	-0.3
Wears glasses or contact lenses	1.4	1.7	3.7	0.4	-1.9	-1.5	-0.0	-1.3	-1.9	-0.4
Ever taken oral contraceptive pill	0.4	0.4	1.2	0.2	-1.1	-0.1	-0.5	-1.1	-0.1	-0.0
Hearing aid user	0.9	1.0	2.4	0.0	1.4	0.2	-1.6	0.8	-0.9	1.1
Mother’s age at death	0.3	0.3	0.7	-0.3	-0.6	-0.4	0.5	-0.1	0.8	-0.8
Financial situation satisfaction	0.2	0.2	0.8	-0.3	0.7	0.2	0.3	0.9	0.0	0.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	-0.4	0.7	-0.2	-0.4	0.9	0.8	0.1
Commuting to job workplace: Public transport	0.3	0.4	0.8	-0.9	-0.8	0.4	0.4	-0.6	0.7	-0.2
Eye problems/disorders: Glaucoma	1.1	1.3	2.0	-1.4	-1.3	1.0	0.4	-0.9	-1.4	-1.2
Medication: Blood pressure	0.9	1.6	5.1	-1.7	-0.0	0.4	2.2	0.3	1.7	-0.6
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.6	2.4	-0.8	-0.8	-1.7	-1.1	-0.5	1.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.0	0.2	-0.4	-1.4	0.1	-0.5	-1.1	0.4
High cholesterol (Self-reported)	0.8	1.3	3.2	1.1	-1.1	-1.8	-0.3	-1.2	-1.4	0.3
Medication: Bendroflumethiazide	1.0	1.5	4.7	-0.4	-1.9	0.7	-0.3	-2.2	-1.0	-0.6
Medication: Paracetamol	0.4	0.6	2.7	0.2	-0.6	-0.8	-0.1	-0.8	-1.6	-0.2
Medication: Lisinopril	2.2	2.9	5.9	-2.4	0.2	-0.3	2.4	0.4	2.0	-2.1
Medication: Atorvastatin	0.4	0.5	1.5	0.6	-0.6	-1.2	-0.2	-0.5	0.7	0.5
Illnesses of father: High blood pressure	0.2	0.2	0.6	-0.1	-0.4	0.8	-0.1	-0.6	0.0	-0.6
Alcohol drinker status: Never	0.7	0.9	4.4	-0.5	0.2	-0.9	2.1	-0.3	-0.4	-0.6
Ever smoked	1.8	3.1	6.6	-0.7	-2.5	0.3	-0.2	-1.8	-2.6	-2.3
Basal metabolic rate	0.8	4.7	14.9	0.0	3.9	0.1	-0.9	2.8	-0.4	3.0
Leg fat percentage (left)	0.4	1.3	2.1	-1.3	1.4	0.8	1.3	0.9	1.4	0.1
Arm fat-free mass (left)	1.1	5.6	17.0	0.2	4.1	0.2	-1.1	3.0	-0.5	3.3
Number of operations (self-reported)	1.1	1.6	9.2	-0.3	-0.4	-3.0	0.5	0.0	-1.3	-0.3
Average weekly beer plus cider intake	0.6	0.9	1.9	1.3	-0.3	-1.1	-1.4	-0.8	-0.4	0.8
Irritability	0.4	0.6	2.0	1.1	0.4	0.4	-0.6	0.2	0.6	1.4
Risk taking	2.1	3.1	8.7	1.2	2.4	-0.9	-0.5	1.9	1.2	3.0
Ever had prostate specific antigen (PSA) test	1.8	2.1	3.5	-0.2	-1.7	1.3	0.7	-1.6	-1.9	-1.9
Fractured/broken bones in last 5 years	0.3	0.4	1.2	0.2	0.4	-1.1	-0.2	0.9	-0.6	-0.2
Age started oral contraceptive pill	0.4	0.5	1.3	-1.1	0.8	0.9	0.4	0.1	0.7	-0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.8	0.0	-0.5	-0.9	0.4	0.0	0.7	-0.3
Ever depressed for a whole week	0.4	0.5	1.4	-0.9	-0.2	0.9	0.4	0.0	0.2	-1.2
Unable to work because of sickness or disability	0.8	1.0	2.2	1.5	-1.4	-0.3	-0.4	-1.3	-0.8	0.3
Commuting to job workplace: Cycle	0.5	0.6	1.6	0.4	-0.9	-0.3	0.1	-1.0	-1.3	-0.4
Myopia	0.7	0.9	2.0	-0.1	-1.1	-0.7	0.5	-1.2	-1.4	-1.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.9	0.7	0.8	-0.5	-0.4	0.9	0.1	0.8
Cholesterol lowering medication	0.3	0.5	1.0	0.5	-0.6	-1.0	0.6	-0.9	0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.1	-0.0	-0.7	0.8	0.5	-1.1	0.1	-0.8
Pain experienced in last month	1.8	3.0	6.0	-2.5	1.7	1.9	1.9	1.8	0.6	-0.9
Supplements: Calcium	0.4	0.4	1.7	-0.2	0.2	1.3	0.5	0.8	-0.6	-0.2
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	0.7	0.2	1.0	0.3	0.6	0.3	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	3.8	-0.2	0.7	0.7	0.9	-0.1	1.9	0.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.2	0.8	1.1	-2.0	-1.1	1.4	-1.5	0.7
Heart disease (siblings)	0.5	0.6	2.2	0.2	1.5	0.1	-0.6	0.8	-0.4	0.9
Alcohol drinker status: Previous	1.1	1.3	4.7	2.2	-1.2	0.7	-0.7	-1.1	-0.0	0.9
Pack years of smoking	0.4	0.5	1.3	-0.5	0.3	-0.7	1.2	0.6	-1.0	-0.2
Impedance of whole body	1.5	7.4	25.5	-0.2	-5.0	0.9	0.7	-3.7	0.1	-3.3
Leg fat mass (left)	0.4	1.6	4.9	-1.3	2.2	0.7	0.7	1.5	0.9	0.8
Arm predicted mass (left)	1.0	5.1	16.6	0.0	4.1	0.5	-0.7	3.0	-0.4	3.0