Hub : Genes

MASP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1820	0.0520	4.2e-04	0.107	NA	0.103	NA	0.101	4.7e-09	NA	9.0e-09	NA	1.2e-08
2	GTEx	Adrenal Gland	0.4219	0.1090	4.9e-04	0.061	NA	0.153	NA	0.113	3.1e-03	NA	4.0e-06	NA	7.3e-05
3	GTEx	Brain Hypothalamus	0.4240	0.1360	6.5e-03	0.016	NA	0.017	NA	-0.004	1.3e-01	NA	1.3e-01	NA	4.1e-01
4	GTEx	Brain Nucleus accumbens basal ganglia	0.6480	0.1330	6.1e-04	-0.011	NA	0.113	NA	0.129	8.7e-01	NA	6.2e-04	NA	2.5e-04
5	GTEx	Lung	0.2463	0.0510	5.1e-07	0.099	NA	0.158	NA	0.152	5.7e-08	NA	3.8e-12	NA	9.7e-12
6	TCGA	Lung Adenocarcinoma	0.0516	0.0189	1.0e-04	0.043	0.036	0.034	NA	0.034	7.8e-06	3.7e-05	7.0e-05	NA	7.4e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	2.2	-0.9	0.0	0.0	-0.5	-1.5	0.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.3	0.9	0.0	-1.0	-0.3	0.1
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	0.0	1.2	0.0	-0.5	-0.5	-1.0
Depression (Nagel 2018)	0.7	1.0	2.8	-1.6	-0.1	0.0	0.4	-0.9	-1.7
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.0	1.4	0.6	0.0	-0.0	-0.3	0.7
Neuroticism (Nagel 2018)	0.2	0.6	1.7	0.2	1.3	0.0	-0.9	-0.9	-0.5
Schizophrenia (2018)	0.3	0.6	1.3	1.1	1.1	0.0	-0.8	0.8	-0.2
Schizophrenia vs Biploar Disorder	0.6	0.8	2.4	-0.1	-0.6	0.0	1.2	1.5	-0.5
Worry (Nagel 2018)	0.2	0.3	1.3	-0.4	-0.3	0.0	-1.2	-0.4	0.6
Alzheimer’s Disease (in mother)	0.2	0.3	0.6	0.3	0.8	-0.4	0.0	-0.6	-0.6
Alzheimer’s Disease (in father)	0.8	0.9	2.7	-0.4	0.3	-1.1	0.9	0.6	-1.6
Alzheimer’s Disease (including proxy)	0.5	0.7	2.0	-0.1	0.4	-0.3	0.9	-0.9	-1.4
Crohns Disease (2017)	0.8	1.7	4.9	-1.5	1.0	-0.3	0.9	-2.2	-1.1
Irritable Bowel Disease (IBD)	1.2	3.0	5.4	-2.0	1.9	-1.2	0.2	-2.3	-1.8
Ulcerative Colitis (UC)	1.1	2.1	3.2	-1.3	1.8	-1.4	-0.6	-1.5	-1.7
Major Depression (MDD)	0.7	0.9	2.3	-1.5	0.9	0.0	0.7	-1.3	0.1
Reaction Time	0.4	0.8	2.4	0.7	-1.6	1.2	-0.2	0.4	0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.8	0.9	1.2	-1.7	-0.3	-0.3	0.8
Breast Cancer	0.3	0.7	1.3	0.8	-0.9	0.4	-0.6	-1.1	0.8
Ovarian Cancer	0.3	0.4	0.9	0.3	0.7	-0.4	-0.6	-0.9	-0.6
Prostate Cancer	1.0	1.3	3.3	-1.8	-0.1	1.4	-1.2	-0.8	-0.8
Age at First Birth	1.0	1.4	3.2	-1.8	-1.3	1.7	-0.8	0.3	0.2
Bipolar Disorder (2011)	0.7	0.7	3.8	-0.3	-0.2	0.0	-2.0	-0.0	0.1
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	1.4	-0.7	0.0	-0.6	0.8	0.1
Coronary Artery Disease (CAD)	0.5	0.6	1.6	0.7	0.9	0.0	-0.7	0.5	-1.3
Crohns Disease (2012)	0.2	0.3	1.0	-1.0	-0.1	0.0	0.4	-0.4	-0.5
Mean Putamen Volume	0.1	0.1	0.2	0.4	0.4	0.0	-0.3	0.1	-0.3
Fasting Glucose	1.0	1.1	2.3	1.4	-0.6	-1.3	-0.4	1.5	0.6
HbA1C	0.7	0.8	1.6	0.9	-1.1	1.0	-0.2	-0.1	1.2
HDL Cholesterol	0.6	1.0	4.8	0.4	0.9	0.0	-0.4	2.2	0.2
LDL Cholesterol	0.4	0.6	2.2	-0.7	-0.1	0.0	1.1	-1.5	-0.0
Lupus	2.4	3.7	9.1	0.7	-3.0	0.0	0.6	2.4	2.5
Neuroticism (2016)	0.3	0.4	2.0	1.4	-0.2	0.2	-0.3	0.7	0.2
Primary Biliary Cirrhosis	0.6	0.9	3.0	-0.4	1.2	0.6	-0.3	-0.4	-1.7
Rheumatoid Arthritis	0.8	1.1	3.2	0.4	-0.8	0.0	1.8	1.4	0.5
Schizophrenia (2014)	0.2	0.4	1.1	0.5	1.1	0.0	-0.7	0.1	-0.8
Triglycerides	1.0	1.6	4.0	-0.5	0.8	0.0	2.0	-1.6	-1.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.7	-0.1	-0.9	0.0	-1.6	0.7	-0.3
Ulcerative Colitis	0.1	0.1	0.6	-0.4	0.8	0.0	0.3	-0.0	-0.1
Blood Eosinophil Count	0.2	1.5	3.4	-1.3	0.2	1.2	1.3	-1.0	-1.8
Blood Platelet Count	0.1	0.9	5.0	-0.3	-0.4	0.1	0.2	-2.2	0.2
Blood Red Count	0.0	0.4	1.3	-0.8	0.2	-1.2	0.4	0.3	-0.6
Blood White Count	0.4	2.9	5.9	-1.8	1.9	0.3	0.0	-2.4	-2.2
Heel T-Score	0.1	1.1	4.0	-2.0	0.1	0.7	0.3	1.3	0.7
BMI	0.1	0.6	2.4	0.6	-0.8	0.2	1.5	-0.1	-0.2
Height	0.4	8.1	43.3	1.2	-0.6	1.8	0.6	-6.6	-0.2
Waist Hip Ratio (WHR)	0.1	0.4	1.0	-0.1	-0.5	-0.4	-1.0	0.6	0.8
Systolic Blood Pressure	0.7	3.6	9.2	-3.0	1.8	0.7	-1.9	-0.4	-2.3
Smoking Status	0.9	2.1	8.8	-0.3	1.5	-0.3	0.9	-3.0	-0.6
Allergy or Eczema	0.8	2.2	11.5	0.3	-0.2	0.4	0.1	-3.4	1.2
Cardiovascular Disease	0.1	0.4	0.7	-0.4	-0.1	-0.7	-0.3	0.9	-0.8
Hypothyroidism (self reported)	0.5	1.2	4.1	-0.9	-1.3	-2.0	-0.3	0.7	-0.2
Respiratory disease	2.2	5.0	13.9	-0.9	0.8	-0.7	3.0	-3.7	-2.2
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.7	-0.2	0.6	-1.3	-0.4	0.7	-0.3
Lung FEV1/FVC ratio	0.5	2.7	7.3	0.9	-1.7	1.0	1.3	1.6	2.7
Lung FVC	0.2	1.2	3.3	1.1	0.6	-1.5	-0.3	1.8	0.3
Neuroticism	0.3	0.6	2.1	-0.8	0.9	-0.1	0.4	-1.4	0.1
Chronotype (morning person)	0.5	1.1	4.7	0.4	-0.5	0.8	-2.2	0.4	0.8
Hair Pigment	0.2	5.5	18.0	-0.9	4.2	0.5	-0.0	-2.1	-3.1
Tanning	0.0	0.1	0.6	-0.0	-0.8	-0.3	0.0	0.1	0.0
Hand grip strength (left)	0.1	0.2	0.9	-0.4	-0.2	0.0	-0.1	-0.4	1.0
Number of treatments/medications taken	0.2	0.4	0.9	0.9	0.5	0.0	-0.0	0.9	-0.4
Average weekly spirits intake	0.6	0.8	2.9	0.7	0.3	0.0	-0.7	1.7	0.9
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.4	0.5	0.0	-0.7	-0.2	0.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	-1.1	-0.7	0.0	0.8	-0.4	-0.9
Hearing difficulty/problems: Yes	0.1	0.1	0.5	0.5	-0.3	0.0	-0.1	0.1	0.7
Relative age of first facial hair	0.1	0.3	0.8	-0.4	-0.4	0.0	-0.6	-0.9	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.5	0.7	0.0	0.6	-0.3	0.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.4	1.9	0.1	0.0	-0.3	-0.9	-1.1
Ever had hysterectomy (womb removed)	0.5	0.5	1.8	-1.3	-0.2	0.0	-1.1	-0.1	-0.4
Systolic blood pressure, automated reading	0.3	1.0	2.6	-1.1	0.5	0.0	-1.6	1.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.0	1.0	-0.9	0.0	-1.4	1.4	0.0
Angina	1.3	1.8	3.6	1.7	1.9	0.0	0.6	1.3	-1.4
Medication for hormone replacement therapy	0.2	0.3	1.1	-0.1	0.5	0.0	-1.1	-0.5	-0.2
Vitamin and mineral supplements	0.5	0.7	2.1	1.5	0.1	0.0	0.8	0.8	0.7
Supplements: Zinc	0.3	0.3	1.2	0.6	-0.1	0.0	0.6	1.1	0.2
Medication: Co-codamol	1.6	1.8	4.9	-0.3	2.2	0.0	2.0	-0.2	-1.4
Medication: Metformin	0.9	1.2	3.5	1.3	1.9	0.0	-0.9	0.1	-1.2
Diabetes (father)	0.6	0.7	2.9	1.0	0.6	0.0	-1.7	-0.4	0.0
Diabetes (mother)	2.1	2.7	8.0	-2.8	1.1	0.0	0.0	-1.6	-2.0
Severe depression (siblings)	0.4	0.4	1.2	0.8	0.7	0.0	0.6	-0.0	-1.1
Pack years adult smoking proportion	0.4	0.6	1.2	1.1	0.6	0.0	-0.4	0.8	-1.0
Impedance of leg (right)	0.2	1.0	3.9	-0.2	1.1	0.0	-2.0	-0.3	0.9
Leg fat-free mass (left)	0.7	3.9	10.0	-0.0	-0.1	0.0	3.1	-3.2	-2.0
Trunk fat percentage	0.3	1.2	4.4	2.1	1.0	0.0	0.8	-0.1	-1.1
Hand grip strength (right)	0.3	0.9	2.1	-0.1	-1.0	0.0	1.4	-0.6	1.5
Townsend deprivation index at recruitment	1.0	1.4	3.2	-1.3	1.1	0.0	-0.7	-1.8	-1.1
Current tobacco smoking	0.1	0.2	0.8	0.5	0.3	0.0	0.1	-0.9	-0.2
Average weekly fortified wine intake	0.5	0.5	1.1	-1.0	0.9	0.0	-0.6	-1.0	-0.1
Maternal smoking around birth	0.9	1.2	4.0	-0.7	1.4	0.0	0.4	-2.0	-0.9
Fed-up feelings	0.1	0.2	0.8	0.9	0.2	0.0	-0.4	0.4	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.5	-0.3	1.2	0.0	1.9	-0.5	-1.6
Relative age voice broke	0.5	0.8	1.9	-1.0	1.3	0.0	0.4	-1.4	-0.4
Taking other prescription medications	0.4	0.6	1.7	1.0	0.2	0.0	0.7	0.5	-1.3
Age when periods started (menarche)	0.1	0.2	0.8	0.9	0.3	0.0	-0.5	-0.5	-0.2
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.5	-0.8	-0.9	0.0	-1.9	0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.3	-0.2	1.1	0.0	0.3	-0.3	-0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.9	0.2	1.4	0.0	-0.6	-0.3	-1.2
Qualifications: CSEs or equivalent	1.3	1.7	5.3	-2.3	0.7	0.0	-1.1	-1.7	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	1.9	-1.4	-0.0	0.0	0.8	-0.4	-0.2
High blood pressure	0.3	0.9	3.6	-0.0	0.1	0.0	-0.8	0.9	-1.9
Hayfever, allergic rhinitis or eczema	0.9	1.9	7.0	-0.5	-0.8	0.0	-0.5	-2.6	1.8
Multivitamins +/- minerals	1.3	1.6	4.5	-1.8	0.4	0.0	-2.1	-1.3	-0.6
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.1	-0.4	0.0	0.6	0.7	0.1
Supplements: Glucosamine	0.3	0.4	1.9	-0.5	-0.4	0.0	-1.4	-0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.1	-0.5	0.4	0.0	-0.1	1.0	-0.4
Medication: Atenolol	2.6	3.2	13.0	-0.0	3.6	0.0	0.2	-2.1	-1.3
Medication: Levothyroxine sodium	0.3	0.5	1.0	-1.0	0.0	0.0	-0.9	0.3	-0.9
Sitting height	0.6	4.0	18.4	0.2	0.2	0.0	1.8	-4.3	-1.5
Chronic bronchitis/emphysema (father)	1.3	1.6	8.5	0.9	-0.2	0.0	2.9	0.3	0.0
High blood pressure (mother)	0.3	0.4	1.3	0.3	0.9	0.0	0.5	0.2	-1.1
Body mass index (BMI)	0.2	0.9	3.0	1.1	0.4	0.0	1.7	0.3	-1.1
Impedance of leg (left)	0.3	1.5	7.1	0.1	0.5	0.0	-2.7	0.1	1.3
Leg predicted mass (left)	0.7	3.7	9.5	-0.0	-0.3	0.0	3.0	-3.1	-1.9
Trunk fat mass	0.3	1.3	3.1	1.8	0.5	0.0	1.4	-0.9	-1.3
Waist circumference	0.3	1.3	2.5	1.6	0.6	0.0	1.2	-1.0	-1.5
Number of incorrect matches in round	0.2	0.4	1.9	1.4	-0.3	0.0	-0.2	0.3	-0.3
Past tobacco smoking	0.3	0.6	2.8	0.1	-1.7	0.0	-0.2	0.9	0.2
Alcohol usually taken with meals	0.6	1.0	2.3	1.0	-1.5	0.0	0.7	-0.7	1.3
Nervous feelings	0.5	1.0	2.5	-0.0	-1.5	0.0	-0.4	1.1	1.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.5	-0.1	0.1	0.0	-0.2	0.5	0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.3	1.1	0.3	0.0	-0.6	-1.0	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	2.1	1.4	-0.2	0.0	-0.8	-0.4	0.4
Had menopause	1.4	1.7	9.1	3.0	-0.8	0.0	-0.1	0.8	-0.1
Had other major operations	0.3	0.3	0.9	0.4	-0.9	0.0	-0.4	1.0	0.2
Forced vital capacity (FVC)	0.2	0.9	2.4	-0.1	-0.7	0.0	1.5	-1.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.1	0.1	-0.3	0.2	0.0	0.1	0.3	0.4
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	1.0	0.4	0.0	0.1	0.7	0.3
Qualifications: None of the above	0.8	1.8	6.2	1.4	2.5	0.0	-1.1	0.6	-0.9
Financial difficulties in last 2 years	0.8	1.1	2.2	-1.2	0.9	0.0	0.2	-1.5	-1.5
Mouth/teeth dental problems	0.3	0.4	1.1	-1.0	-0.6	0.0	0.2	0.9	0.6
Heart attack	1.2	1.6	7.1	-0.1	2.7	0.0	0.4	-0.3	-1.5
Allergy	0.8	1.9	6.9	1.2	1.3	0.0	-0.5	2.6	-1.1
Pain all over the body in last month	0.4	0.5	1.3	-1.1	0.4	0.0	-0.3	-1.1	0.3
Diabetes (self-reported)	0.4	0.7	1.8	1.4	0.3	0.0	-0.5	1.3	-0.1
Hayfever/allergic rhinitis (self-reported)	2.1	2.7	11.9	-1.4	-0.4	0.0	-1.5	-3.4	0.3
Medication: Ramipril	0.6	0.8	2.8	1.7	0.9	0.0	-0.4	1.0	-0.2
Medication: Simvastatin	0.8	1.1	2.7	-0.6	1.6	0.0	1.5	0.6	-1.0
Fluid intelligence score	0.1	0.2	0.8	0.2	0.5	0.0	0.5	-0.9	-0.1
Illnesses of siblings	1.4	2.0	6.1	-1.6	1.6	0.0	-0.4	-2.5	-0.5
Neuroticism score	0.1	0.2	1.3	0.1	-0.2	0.0	0.3	-0.2	1.1
Weight	0.5	2.4	5.7	0.7	0.2	0.0	2.2	-2.4	-1.9
Impedance of arm (right)	0.2	1.1	4.3	0.6	0.7	0.0	-2.1	0.5	1.0
Arm fat percentage (right)	0.2	0.6	2.0	1.4	0.4	0.0	0.5	0.9	-0.7
Trunk fat-free mass	0.6	3.4	9.8	-0.3	-1.2	0.0	2.8	-3.1	-1.3
Hip circumference	0.8	3.3	6.1	1.1	1.1	0.0	2.3	-2.5	-2.5
Time employed in main current job	0.5	0.6	1.6	-1.2	0.0	0.0	1.3	-0.2	-0.8
Alcohol intake versus 10 years previously	0.7	1.0	3.7	-0.4	1.3	0.0	0.8	-0.3	-1.9
Father’s age at death	0.8	1.0	4.1	-0.0	-0.4	0.0	0.1	-1.4	2.0
Worrier / anxious feelings	0.5	0.9	3.0	1.1	-0.6	0.0	1.0	0.3	1.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.3	-1.6	0.1	0.0	-0.1	0.4	-1.8
Falls in the last year	0.4	0.6	2.5	0.5	-0.7	0.0	0.1	-1.6	-0.4
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	0.8	0.4	0.0	0.5	0.3	1.1
Number of live births	0.8	1.2	3.0	1.7	0.8	0.0	0.8	1.6	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.1	-0.1	-0.9	0.0	1.4	-1.0	0.0
Pulse rate	0.1	0.2	0.8	0.9	-0.5	0.0	-0.2	-0.1	-0.1
Happiness	0.5	0.6	1.5	1.2	-1.2	0.0	-0.1	0.3	0.6
Noisy workplace	1.1	1.3	4.8	2.2	-1.0	0.0	-0.3	0.8	1.3
Qualifications: A levels/AS levels or equivalent	0.7	1.5	5.4	-0.8	-2.3	0.0	0.7	0.2	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.9	-1.7	0.1	0.0	0.2	-0.8	0.2
Mouth/teeth dental problems: Dentures	0.7	1.2	4.5	2.1	1.2	0.0	0.7	0.3	-0.7
Asthma	2.2	4.3	11.0	-1.4	-0.2	0.0	3.3	-3.2	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	5.5	-2.3	0.6	0.0	-0.9	-0.5	-0.1
Medication: Cholesterol lowering	0.9	1.3	3.9	-1.2	2.0	0.0	0.3	-0.3	-1.6
Depression (self-reported)	0.2	0.2	0.4	-0.5	-0.6	0.0	0.4	-0.6	0.6
Medication: Lansoprazole	0.6	0.7	2.9	0.8	-0.0	0.0	0.7	1.7	-0.4
Prospective memory result	0.1	0.1	0.2	-0.4	0.3	0.0	0.0	-0.5	-0.2
Lung cancer (father)	0.7	0.8	3.3	1.8	1.1	0.0	-0.2	0.2	-0.6
Illnesses of mother	0.1	0.2	0.7	-0.8	-0.2	0.0	-0.1	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.7	0.1	-1.3	0.0	0.9	-0.8	1.0
Pulse wave Arterial Stiffness index	1.0	1.2	3.3	0.8	-1.0	0.0	1.8	0.1	1.5
Impedance of arm (left)	0.2	0.9	2.6	0.8	1.0	0.0	-1.6	0.4	1.0
Arm fat mass (right)	0.2	0.9	2.6	1.1	0.1	0.0	1.6	-0.5	-1.1
Trunk predicted mass	0.6	3.5	10.2	-0.4	-1.2	0.0	2.8	-3.2	-1.3
Standing height	0.6	6.3	33.6	-0.5	-0.6	0.0	1.3	-5.8	-1.4
Length of working week for main job	0.3	0.3	0.8	-0.9	-0.3	0.0	0.8	-0.2	-0.5
Exposure to tobacco smoke at home	0.2	0.2	0.9	-0.5	-0.3	0.0	0.9	-0.1	-0.1
Breastfed as a baby	0.8	1.0	4.0	-2.0	0.1	0.0	1.0	-0.3	-1.0
Tense / ‘highly strung’	0.1	0.2	0.6	-0.8	0.3	0.0	-0.6	0.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	5.5	-0.4	2.3	0.0	0.8	-1.7	-1.7
Hair/balding pattern: Pattern 4	0.4	1.0	3.1	0.1	-1.6	0.0	-0.1	1.8	0.4
Birth weight of first child	1.6	2.8	5.1	0.3	1.6	0.0	2.1	-2.1	-2.2
Peak expiratory flow (PEF)	0.5	1.2	3.5	-1.1	-0.7	0.0	1.9	-1.4	-0.2
Pulse wave reflection index	1.2	1.5	5.2	-0.6	1.0	0.0	2.3	-1.6	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.8	-0.8	0.0	-0.6	0.4	0.6
Loud music exposure frequency	1.1	1.2	2.6	1.0	1.6	0.0	-0.2	-1.3	-1.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.7	6.8	-1.3	-2.6	0.0	-0.4	-0.0	1.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.2	0.1	0.0	0.0	1.1	-0.3	-0.6
Blood clot in the leg (DVT)	0.1	0.2	0.7	0.0	-0.8	0.0	-0.2	-0.3	0.3
Medication: Paracetamol	1.2	2.1	4.6	-2.1	0.9	0.0	0.8	-2.1	-1.3
Headache pain in last month	0.5	0.8	2.6	-1.6	0.6	0.0	0.1	-1.1	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.7	0.2	-1.6	0.0	-0.2	-0.0	1.2
Glaucoma (self-reported)	0.6	0.7	2.4	1.0	-0.4	0.0	0.2	1.5	0.6
Gout (self-reported)	1.2	1.6	3.5	-1.9	1.6	0.0	0.4	-0.7	-1.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.5	-0.9	-1.2	0.0	-0.5	0.9	0.2
Medication: Amlodipine	0.5	0.7	1.8	-1.3	0.2	0.0	-0.1	-0.9	-1.3
Medication: Ventolin 100micrograms inhaler	1.7	2.2	8.1	-0.9	1.0	0.0	1.6	-2.8	-1.0
Birth weight	0.4	0.8	3.5	-0.4	-0.3	0.0	0.8	-1.9	0.6
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.6	-1.3	-1.0	0.0	-0.9	0.2	-0.1
High blood pressure (siblings)	1.0	1.4	5.6	0.3	-1.3	0.0	0.9	2.4	0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	2.4	0.3	-1.1	0.0	0.9	-1.6	0.7
Body fat percentage	0.3	1.0	3.6	1.9	1.0	0.0	0.7	0.3	-1.0
Leg fat percentage (right)	0.2	0.7	1.9	1.4	0.8	0.0	0.8	1.0	-0.5
Arm fat-free mass (right)	0.7	3.6	9.2	-0.1	-0.7	0.0	2.9	-3.0	-1.9
Exposure to tobacco smoke outside home	0.6	0.8	2.1	1.1	1.4	0.0	-0.5	-0.1	-1.1
Comparative body size at age 10	0.2	0.6	2.0	-1.4	-0.9	0.0	0.7	0.6	-0.2
Number of full brothers	0.4	0.5	1.5	-0.8	-1.2	0.0	0.6	0.4	-0.2
Worry too long after embarrassment	0.2	0.3	1.1	0.2	0.2	0.0	0.5	0.5	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.4	0.6	1.1	0.0	1.6	-1.1	-1.1
Wheeze or whistling in the chest in last year	0.7	1.2	6.0	0.1	-2.4	0.0	1.0	-0.5	-0.2
Number of children fathered	0.5	0.5	1.6	-0.6	0.2	0.0	1.1	-1.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.0	1.4	1.0	0.0	1.1	1.3	-0.2
Age at first live birth	1.1	1.9	7.0	-1.9	-2.6	0.0	0.2	-0.8	0.4
Pulse wave peak to peak time	1.1	1.2	3.1	-0.8	1.0	0.0	-1.6	-0.5	-1.7
Health satisfaction	0.2	0.3	1.3	1.1	-0.2	0.0	0.2	-0.3	-0.3
Shortness of breath walking on level ground	1.0	1.2	3.6	-1.0	1.4	0.0	0.1	-1.9	-0.6
Qualifications: College or University degree	0.2	0.8	2.6	-0.5	-1.1	0.0	1.6	-0.5	0.6
Eye problems/disorders: None of the above	0.4	0.5	1.5	-0.9	0.5	0.0	-0.5	-0.3	-1.2
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.2	0.0	0.3	0.0	0.0	-1.0	-1.1
Emphysema/chronic bronchitis	0.2	0.2	0.9	0.0	0.1	0.0	-0.9	0.2	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	3.0	1.7	-0.7	0.0	-0.9	-0.2	0.6
Neck or shoulder pain in last month	0.8	1.2	3.1	1.8	1.5	0.0	0.3	-0.5	-1.2
Medication: Blood pressure	0.3	0.5	1.0	0.4	0.8	0.0	-0.7	0.8	-1.0
Angina (self-reported)	1.2	1.6	4.0	1.4	2.0	0.0	0.1	0.9	-1.7
Migraine (self-reported)	0.1	0.1	0.3	-0.1	-0.0	0.0	-0.1	-0.3	-0.6
Medication: Ibuprofen	0.8	1.0	4.4	-2.1	0.5	0.0	-1.0	-0.4	-0.2
Medication: Allopurinol	0.5	0.7	1.8	-1.3	1.2	0.0	-0.3	-0.1	-1.0
Medication: Omeprazole	1.1	1.3	3.1	-1.8	0.2	0.0	1.2	-1.7	-0.5
Medication: Seretide 50 evohaler	1.8	2.1	5.9	-2.3	-1.1	0.0	0.3	-2.4	-0.4
Mean time to correctly identify matches	0.2	0.5	1.6	1.3	-0.9	0.0	-0.7	0.1	-0.1
Heart disease (mother)	1.4	1.7	3.1	1.8	-0.0	0.0	1.3	1.5	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.0	-1.0	-0.9	0.0	-0.4	-0.1	0.1
Whole body fat mass	0.3	1.1	2.6	1.6	0.4	0.0	1.6	-0.5	-1.1
Leg fat mass (right)	0.2	0.9	2.1	1.0	0.5	0.0	1.4	-0.5	-1.2
Arm predicted mass (right)	0.7	3.7	10.9	-0.3	-0.7	0.0	2.8	-3.3	-1.7
Pulse rate, automated reading	0.3	0.9	2.8	0.5	-0.7	0.0	-1.7	-0.2	-1.4
Alcohol intake frequency.	0.9	2.1	5.0	-1.4	0.5	0.0	1.4	-1.8	-2.2
Comparative height size at age 10	0.1	0.7	3.2	-0.7	-0.4	0.0	0.1	-1.8	-0.2
Number of full sisters	2.1	2.5	6.4	-2.5	1.5	0.0	0.1	-2.5	-0.1
Suffer from ‘nerves’	0.4	0.6	1.7	-0.9	-1.3	0.0	-0.9	0.2	0.6
Overall health rating	0.4	0.8	1.9	-1.4	-0.0	0.0	0.6	-1.1	-1.1
Chest pain or discomfort	0.2	0.4	1.6	-0.5	-0.2	0.0	0.4	-0.3	-1.3
Had major operations	0.5	0.6	3.4	0.1	1.9	0.0	0.4	-0.4	-0.1
Age at last live birth	0.3	0.4	1.5	-1.2	-0.2	0.0	0.2	-1.0	-0.1
Family relationship satisfaction	0.9	1.1	3.2	-0.2	-1.8	0.0	-0.2	-1.3	1.4
Leg pain on walking	0.6	0.8	3.2	1.8	-0.4	0.0	-0.9	-0.4	0.8
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.8	1.1	-1.1	0.0	-0.9	1.7	1.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	0.3	0.9	0.0	0.2	-0.5	0.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.7	2.2	1.2	0.0	-0.0	0.9	-0.4
Medication: Aspirin	0.4	0.5	1.3	1.0	0.7	0.0	0.5	1.1	0.0
Supplements: Vitamin C	0.3	0.4	1.0	0.9	-0.3	0.0	0.5	1.0	-0.4
Knee pain experienced in last month	0.3	0.4	0.7	0.7	0.5	0.0	0.7	0.8	-0.7
Hypertension (Self-reported)	0.4	1.1	4.1	-0.5	0.3	0.0	-1.1	0.9	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.0	-1.4	-0.7	0.0	-1.1	-1.1	0.1
Illnesses of father: Heart disease	1.3	1.8	9.1	0.9	0.3	0.0	3.0	1.0	0.1
Illnesses of siblings: Diabetes	0.7	0.8	3.4	1.8	0.2	0.0	-0.9	0.3	-0.8
Smoking status: Previous	0.5	0.8	3.3	-0.2	1.8	0.0	0.6	-0.8	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.6	-1.1	-0.5	0.0	-0.4	-1.6	0.2
Whole body fat-free mass	0.6	3.7	10.3	-0.2	-0.9	0.0	2.9	-3.2	-1.6
Leg fat-free mass (right)	0.6	3.4	9.4	-0.0	-0.6	0.0	2.8	-3.1	-1.7
Arm fat percentage (left)	0.2	0.9	2.6	1.6	0.8	0.0	0.9	0.7	-1.0
Average weekly red wine intake	0.3	0.4	1.8	1.4	-0.3	0.0	-0.0	0.6	0.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.3	0.6	-1.2	0.0	-0.5	1.5	1.2
Mood swings	0.4	0.7	1.9	-0.7	1.1	0.0	1.4	-0.4	-0.5
Loneliness, isolation	0.4	0.5	1.7	-0.1	-0.4	0.0	-1.3	0.5	0.9
Long-standing illness, disability or infirmity	0.8	1.2	4.9	2.2	-0.3	0.0	0.4	1.2	0.9
Ever had bowel cancer screening	0.9	1.1	2.2	1.4	0.5	0.0	-1.1	1.5	0.9
Diabetes diagnosed by doctor	0.5	0.9	2.3	1.5	1.1	0.0	-1.0	0.9	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	2.0	0.0	-0.4	0.0	-0.4	0.2	1.4
Friendships satisfaction	0.7	0.9	3.7	-0.2	-1.2	0.0	-1.9	-0.0	0.6
Qualifications: nursing, teaching	0.3	0.4	1.4	0.7	0.6	0.0	1.2	-0.4	-0.3
Commuting to job workplace: Walk	0.4	0.4	1.0	0.8	0.1	0.0	1.0	-0.1	-0.8
Eye problems/disorders: Cataract	0.7	0.8	3.9	0.0	-1.1	0.0	-0.2	0.1	2.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.5	-1.3	-0.2	0.0	-0.6	-1.6	0.1
Medication for cholesterol	0.8	1.2	6.1	0.1	-0.0	0.0	1.0	-2.5	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	0.3	0.4	0.0	0.8	0.0	-0.7
Back pain experienced in last month	0.5	0.7	2.5	0.9	-0.9	0.0	1.6	-0.4	0.1
Mineral and other dietary supplements	0.3	0.4	1.4	0.1	0.8	0.0	1.2	0.4	-0.6
Breast cancer (self-reported)	0.1	0.2	0.4	-0.6	0.3	0.0	0.3	0.6	0.4
Asthma (self-reported)	2.5	4.9	12.7	-1.8	0.0	0.0	3.6	-3.3	-1.5
Osteoporosis (self-reported)	0.1	0.2	0.9	0.1	-0.1	0.0	0.9	0.4	-0.1
Osteoarthritis (self-reported)	0.4	0.5	1.1	-0.2	-0.8	0.0	-1.0	-0.4	1.0
Medication: Aspirin	0.6	0.7	2.1	1.4	0.0	0.0	-0.0	1.5	0.5
Medication: Gliclazide	0.2	0.2	1.0	0.3	-0.3	0.0	-0.3	-0.5	-1.0
Illnesses of father: None of the above (group 1)	1.6	1.9	7.5	-1.3	-0.5	0.0	-2.7	-1.4	-0.4
Smoking status: Current	0.4	0.6	2.1	0.4	0.9	0.0	0.3	-1.5	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.2	0.7	-1.3	0.0	-0.9	1.8	0.9
Whole body water mass	0.6	3.5	9.5	-0.2	-1.0	0.0	2.8	-3.1	-1.6
Leg predicted mass (right)	0.6	3.3	9.1	0.0	-0.6	0.0	2.8	-3.0	-1.7
Arm fat mass (left)	0.3	1.2	3.6	1.3	0.2	0.0	1.9	-0.4	-1.2
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	0.2	1.0	0.0	1.2	-1.1	-0.9
Average weekly champagne plus white wine intake	2.2	3.1	7.1	-2.1	0.2	0.0	2.7	-2.6	0.1
Miserableness	0.4	0.7	2.0	1.2	1.4	0.0	-0.7	0.1	-0.6
Guilty feelings	0.5	0.7	3.1	1.8	0.5	0.0	-0.7	-0.1	0.7
Wears glasses or contact lenses	0.3	0.3	1.5	0.3	-1.2	0.0	0.0	-0.7	-0.2
Ever taken oral contraceptive pill	1.2	1.3	7.2	0.6	0.3	0.0	2.7	-0.6	0.0
Hearing aid user	0.3	0.3	1.0	0.5	0.0	0.0	-1.0	-0.1	0.9
Mother’s age at death	0.1	0.2	0.4	-0.6	-0.6	0.0	-0.0	0.1	0.5
Financial situation satisfaction	1.3	1.6	5.6	-0.1	1.2	0.0	-1.5	-2.4	-0.8
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.7	0.8	0.8	0.0	0.6	-0.3	0.1
Commuting to job workplace: Public transport	0.3	0.4	0.8	0.5	0.9	0.0	0.6	-0.2	-0.9
Eye problems/disorders: Glaucoma	0.5	0.6	1.4	1.2	-0.9	0.0	1.0	0.5	-0.0
Medication: Blood pressure	0.6	1.1	4.2	0.3	-0.9	0.0	-1.2	2.1	0.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.1	0.5	1.4	0.0	0.6	-0.0	-1.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	0.3	-0.2	0.0	-0.5	-0.7	0.6
High cholesterol (Self-reported)	0.5	1.0	3.8	-2.0	0.9	0.0	-0.3	0.8	-0.8
Medication: Bendroflumethiazide	0.1	0.2	1.0	0.4	0.2	0.0	0.1	-0.2	1.0
Medication: Paracetamol	0.7	1.1	3.0	-1.7	0.2	0.0	0.6	-1.6	-1.0
Medication: Lisinopril	0.8	1.1	5.7	0.0	-0.6	0.0	-0.4	2.4	0.3
Medication: Atorvastatin	0.3	0.4	1.4	-0.7	0.0	0.0	-0.7	1.2	-0.3
Illnesses of father: High blood pressure	0.6	0.8	1.4	0.6	-1.2	0.0	0.9	1.1	1.1
Alcohol drinker status: Never	1.7	2.1	8.4	-2.9	-1.0	0.0	0.8	-0.9	-1.3
Ever smoked	0.2	0.3	1.6	-0.2	1.3	0.0	-0.1	-0.3	0.5
Basal metabolic rate	0.6	3.5	9.7	-0.0	-0.6	0.0	2.8	-3.1	-1.8
Leg fat percentage (left)	0.2	0.7	2.2	1.5	0.2	0.0	0.3	1.3	-0.2
Arm fat-free mass (left)	0.8	4.0	11.2	-0.7	-0.8	0.0	2.8	-3.4	-1.8
Number of operations (self-reported)	0.7	1.0	2.3	0.7	1.5	0.0	0.9	-0.9	-1.3
Average weekly beer plus cider intake	0.4	0.5	1.6	-0.3	-0.2	0.0	-1.1	1.3	0.5
Irritability	0.4	0.7	3.9	0.5	-0.1	0.0	0.3	0.0	2.0
Risk taking	0.3	0.4	1.2	-0.1	-0.7	0.0	0.9	1.1	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	-0.9	0.4	0.0	0.4	0.5	-0.6
Fractured/broken bones in last 5 years	1.8	2.4	6.1	-0.3	0.6	0.0	1.3	-2.5	-2.5
Age started oral contraceptive pill	2.4	3.0	6.2	2.5	-1.0	0.0	0.2	2.3	2.3
Diastolic blood pressure, automated reading	0.1	0.5	1.4	-0.9	0.6	0.0	-0.0	-0.5	-1.2
Ever depressed for a whole week	0.9	1.1	2.8	0.8	-1.7	0.0	-0.8	0.9	1.3
Unable to work because of sickness or disability	0.6	0.7	1.2	-1.1	0.7	0.0	0.5	-1.1	-1.0
Commuting to job workplace: Cycle	0.9	1.0	2.6	-0.8	-1.4	0.0	-1.6	0.6	0.8
Myopia	0.3	0.4	1.6	-0.8	-0.2	0.0	-1.2	-0.6	0.1
Vascular/heart problems diagnosed by doctor	0.4	1.2	4.7	-0.5	-0.8	0.0	0.6	-1.1	2.2
Cholesterol lowering medication	1.0	1.5	8.1	0.2	-0.4	0.0	-0.1	2.8	0.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.0	-1.4	-0.8	0.0	1.0	-0.9	-0.5
Pain experienced in last month	0.5	0.8	1.6	-1.1	-1.1	0.0	-1.3	0.6	0.6
Supplements: Calcium	0.2	0.2	0.6	0.4	0.1	0.0	0.8	-0.4	-0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	0.8	-0.4	0.0	-0.0	0.8	-0.0
Heart attack/myocardial infarction (self-reported)	1.2	1.6	6.9	-0.2	2.6	0.0	0.3	-0.3	-1.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	0.2	-1.0	0.0	-0.3	-0.3	0.5
Heart disease (siblings)	1.0	1.3	4.9	1.2	-0.1	0.0	2.2	1.0	0.4
Alcohol drinker status: Previous	0.4	0.5	1.7	1.3	0.9	0.0	0.4	-0.1	-0.2
Pack years of smoking	0.5	0.7	1.6	1.3	0.8	0.0	-0.5	0.6	-1.2
Impedance of whole body	0.2	1.2	5.2	-0.0	1.2	0.0	-2.3	-0.3	0.8
Leg fat mass (left)	0.2	0.8	1.6	1.1	0.3	0.0	1.3	-0.4	-1.2
Arm predicted mass (left)	0.7	3.4	9.2	-0.5	-1.0	0.0	2.6	-3.0	-1.7