Hub : Genes

MAST4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1814	0.0515	1.1e-04	0.101	NA	0.117	NA	0.103	2.5e-08	NA	1.9e-09	NA	1.8e-08
2	GTEx	Cells Transformed fibroblasts	0.1600	0.0470	3.2e-04	0.062	NA	0.086	NA	0.080	1.9e-05	NA	5.6e-07	NA	1.3e-06
3	GTEx	Colon Transverse	0.2490	0.0820	3.5e-03	0.065	NA	0.020	NA	0.039	5.0e-04	NA	3.6e-02	NA	6.0e-03
4	GTEx	Heart Left Ventricle	0.2653	0.0603	1.4e-06	0.275	NA	0.244	NA	0.284	5.4e-15	NA	3.2e-13	NA	1.8e-15
5	GTEx	Muscle Skeletal	0.1578	0.0351	5.6e-07	0.113	NA	0.132	NA	0.140	3.8e-11	NA	6.3e-13	NA	1.2e-13
6	GTEx	Skin Sun Exposed Lower leg	0.3110	0.0690	1.4e-04	-0.003	NA	-0.003	NA	-0.002	9.8e-01	NA	7.8e-01	NA	5.8e-01
7	GTEx	Whole Blood	0.1380	0.0570	6.6e-03	0.061	NA	0.004	NA	0.031	2.5e-06	NA	1.3e-01	NA	7.3e-04
8	METSIM	Adipose	0.0763	0.0255	6.1e-04	-0.001	0.021	0.008	0.021	0.000	4.0e-01	0.00032	1.8e-02	0.00032	2.7e-01
9	ROSMAP	Brain Pre-frontal Cortex	0.0501	0.0255	3.3e-02	0.006	0.003	0.000	0.013	0.010	5.4e-02	0.14000	3.6e-01	0.00690	1.4e-02
10	TCGA	Thyroid Carcinoma	0.0790	0.0280	2.9e-04	0.026	0.027	0.012	NA	0.030	1.3e-03	0.00098	2.3e-02	NA	5.5e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	2.0	3.1	9.9	2.6	2.0	3.1	0.6	2.9	1.3	0.3	-0.0	0.1	0.1
Bipolar Disorder or Schizophrenia	0.5	1.2	4.2	2.0	0.7	1.9	-0.9	1.3	0.0	0.1	-0.4	0.5	0.8
Depressed Affect (Nagel 2018)	0.4	0.9	3.8	0.3	0.0	0.1	2.0	0.0	-0.4	0.6	0.4	-1.9	-0.4
Depression (Nagel 2018)	0.7	1.0	4.8	0.5	-0.5	-0.0	0.9	0.1	1.3	-0.5	1.4	-2.2	0.3
Intelligence (Savage-Jansen 2018)	2.4	7.4	26.6	2.4	2.6	2.5	0.5	3.3	-0.4	5.2	2.3	1.8	3.0
Neuroticism (Nagel 2018)	0.5	1.2	3.9	0.4	-0.5	0.1	1.7	0.1	0.3	-1.2	-0.8	-2.0	-1.6
Schizophrenia (2018)	0.3	0.7	2.8	0.5	-0.8	-0.1	-1.7	-0.6	-1.2	-0.1	-0.6	0.6	0.9
Schizophrenia vs Biploar Disorder	0.6	0.8	2.2	-0.4	-1.1	-1.4	-0.9	-1.2	-1.5	-0.3	-0.2	-0.3	0.1
Worry (Nagel 2018)	1.0	2.1	5.8	1.2	-0.7	1.3	1.3	1.1	0.8	-1.5	-1.4	-1.9	-2.4
Alzheimer’s Disease (in mother)	0.7	0.8	4.4	-0.3	-0.0	-0.4	0.9	1.0	0.4	2.1	-0.6	-0.5	-1.0
Alzheimer’s Disease (in father)	0.6	0.7	4.2	-0.9	0.0	-0.2	-0.8	-0.5	0.5	-0.1	0.9	2.1	0.3
Alzheimer’s Disease (including proxy)	0.5	0.7	3.4	-0.9	0.1	-0.5	-0.2	0.4	0.7	1.0	-0.6	1.8	-0.4
Crohns Disease (2017)	0.5	1.1	5.6	-0.3	0.6	-0.8	-0.6	-0.9	0.2	-0.3	0.3	2.4	-1.6
Irritable Bowel Disease (IBD)	0.9	2.2	5.4	-1.2	-0.2	-2.3	0.0	-2.1	0.4	-1.1	0.8	2.3	-1.8
Ulcerative Colitis (UC)	1.0	1.8	5.7	-1.0	-0.4	-2.4	0.3	-2.0	0.9	-1.0	1.1	1.8	-1.0
Major Depression (MDD)	0.7	0.9	5.9	-0.1	-0.5	0.2	-2.4	0.1	-0.5	-0.1	0.9	-1.2	-0.4
Reaction Time	0.3	0.6	2.0	-0.8	-0.2	-0.9	-0.4	-0.4	0.4	0.4	0.8	1.4	1.0
Verbal and Numeric Reasoning (VNR)	2.7	6.4	19.7	2.6	3.1	2.3	0.5	3.2	-0.2	4.4	2.2	2.1	1.9
Breast Cancer	0.3	0.7	3.6	-0.1	-0.4	0.4	-0.9	0.4	0.1	1.9	0.3	-0.4	-1.2
Ovarian Cancer	1.6	2.1	6.4	0.2	-0.5	1.0	-2.3	0.5	1.6	2.5	-0.5	-0.9	1.9
Prostate Cancer	2.2	3.1	6.1	2.4	1.6	2.4	2.2	2.5	0.1	1.5	0.7	-1.9	0.0
Age at First Birth	1.8	2.6	7.6	2.8	1.2	1.9	-0.6	2.4	0.3	0.4	0.6	-2.1	-1.5
Bipolar Disorder (2011)	4.4	4.3	14.1	2.6	1.8	3.8	-1.6	3.4	1.2	1.1	0.0	-0.5	1.3
Body Mass Index (BMI) (2010)	0.6	0.9	1.9	-1.2	-0.5	-1.3	1.1	-1.2	-0.0	-1.4	0.4	-0.2	-0.7
Coronary Artery Disease (CAD)	1.9	2.3	6.7	1.4	1.8	2.6	1.2	2.0	0.9	1.0	1.3	-1.3	0.4
Crohns Disease (2012)	0.5	0.7	3.1	0.1	-0.0	-0.2	-1.8	-0.2	0.3	-0.1	-0.1	1.1	-1.7
Mean Putamen Volume	1.1	1.2	6.3	-0.9	-0.1	-0.8	1.0	-0.5	0.2	-0.6	-1.0	1.3	2.5
Fasting Glucose	1.0	1.2	8.0	-0.2	0.3	-0.0	2.8	-0.1	-0.0	-0.6	-0.7	-1.6	-0.2
HbA1C	0.6	0.6	2.1	-0.7	-0.8	-0.6	0.8	-0.4	-1.5	0.3	-0.9	-0.9	-0.4
HDL Cholesterol	0.3	0.5	1.7	0.3	-0.7	0.4	-1.3	0.4	-0.7	-0.8	-0.8	-0.3	0.3
LDL Cholesterol	1.6	2.6	12.1	-0.2	1.0	0.2	0.7	0.5	-2.8	3.5	1.8	-0.4	0.2
Lupus	0.7	1.0	3.1	-0.7	-0.3	-1.2	-1.3	-1.0	0.1	-1.8	0.5	-0.9	-1.2
Neuroticism (2016)	0.1	0.2	0.7	-0.5	-0.2	0.4	-0.1	-0.3	0.7	-0.5	-0.0	-0.1	0.8
Primary Biliary Cirrhosis	0.4	0.5	2.7	-0.2	0.3	0.3	-0.6	-0.5	0.8	-0.3	1.6	0.0	1.0
Rheumatoid Arthritis	0.4	0.5	2.1	0.4	1.4	0.4	1.2	0.2	0.4	0.3	0.4	0.6	0.8
Schizophrenia (2014)	0.3	0.7	5.2	0.3	-0.2	0.1	-2.3	-0.5	-0.1	-1.0	-0.5	0.5	-0.1
Triglycerides	0.6	0.9	2.3	-1.2	1.0	-0.9	0.4	-1.5	0.1	0.7	1.3	0.2	-1.1
Type 2 Diabetes (T2D) (2012)	3.6	4.2	11.3	-3.1	-3.4	-2.8	-0.2	-2.6	1.4	-0.9	-1.4	0.0	1.0
Ulcerative Colitis	0.3	0.4	1.6	0.1	-0.7	-1.2	-0.1	-0.3	0.2	-1.2	0.2	-0.2	-0.1
Blood Eosinophil Count	0.5	3.8	11.2	-1.8	-2.0	-2.8	0.4	-1.8	2.1	-3.4	-0.5	-1.9	-0.6
Blood Platelet Count	1.3	14.7	82.4	-2.6	-1.9	-2.4	3.7	-2.2	9.1	-3.0	-3.1	0.1	-3.4
Blood Red Count	0.2	1.5	4.7	-1.6	-1.5	-2.2	0.3	-1.4	-0.4	1.9	0.1	0.0	-0.4
Blood White Count	0.2	1.6	8.8	-0.9	0.2	-0.9	-0.4	-0.6	-0.5	-0.7	-1.0	-3.0	-1.9
Heel T-Score	0.7	5.3	13.6	-2.8	-2.9	-1.6	-0.3	-3.7	-1.5	-1.5	-3.6	-0.1	1.5
BMI	0.8	4.4	13.1	-2.1	-1.9	-3.0	0.0	-2.6	1.7	-1.2	0.6	-1.7	-3.6
Height	0.2	4.3	16.5	2.3	2.1	1.1	1.8	1.5	-0.5	1.6	2.6	-0.8	-4.1
Waist Hip Ratio (WHR)	1.5	6.9	18.1	-4.2	-3.8	-3.7	1.8	-3.6	-0.1	0.6	-2.3	1.0	-0.3
Systolic Blood Pressure	2.3	11.4	25.3	3.2	3.9	4.1	-3.2	3.0	0.1	1.9	5.0	-2.9	-3.8
Smoking Status	1.0	2.3	6.7	-1.5	-2.6	-2.3	-0.4	-1.9	-0.3	-1.7	-1.1	0.7	-0.0
Allergy or Eczema	1.0	2.7	7.3	1.4	1.3	1.1	2.2	1.3	-2.7	0.9	0.1	-1.2	-2.4
Cardiovascular Disease	1.1	3.7	13.7	0.5	1.1	1.1	0.4	0.3	1.8	0.3	1.9	-3.6	-3.7
Hypothyroidism (self reported)	0.8	1.8	4.8	0.9	-0.6	0.4	-1.9	-0.3	-0.7	1.0	1.9	-2.2	-1.6
Respiratory disease	0.1	0.2	0.8	0.0	0.7	-0.0	0.9	0.1	-0.4	0.8	0.1	-0.4	0.1
Type 2 Diabetes (T2D) (2018)	1.8	3.3	8.6	-2.9	-1.9	-2.5	0.8	-2.9	-0.5	-0.5	-1.1	-0.1	-1.8
Lung FEV1/FVC ratio	0.2	0.8	2.6	0.7	1.0	-0.0	-0.4	1.1	0.7	0.3	1.6	-0.8	1.2
Lung FVC	0.7	3.7	18.2	-1.8	-0.9	-2.1	1.8	-1.9	1.5	0.2	0.6	4.3	1.2
Neuroticism	0.4	0.8	3.6	-0.3	-0.4	-0.1	1.3	-0.1	-0.8	-0.5	-0.5	-1.9	-1.3
Chronotype (morning person)	2.1	4.8	9.9	-1.5	-2.3	-3.0	2.8	-2.0	1.1	-2.0	-1.4	-1.8	-3.1
Hair Pigment	0.4	10.2	38.4	6.2	2.9	4.3	-0.9	4.4	0.9	0.5	-1.6	-3.5	-0.1
Tanning	0.5	6.5	16.3	-3.2	-3.1	-4.0	1.2	-3.3	0.1	-1.9	-1.5	3.1	0.1
Hand grip strength (left)	0.7	1.9	4.7	-1.6	-2.2	-1.1	-0.1	-1.7	-0.2	-0.8	-1.8	0.9	-1.6
Number of treatments/medications taken	1.2	2.1	5.1	2.3	2.2	1.7	0.5	1.6	0.4	-0.4	0.7	-0.4	-2.0
Average weekly spirits intake	1.6	2.0	6.1	-2.2	-1.1	-2.5	0.1	-2.1	0.0	-0.4	-0.9	1.6	-0.2
Sensitivity / hurt feelings	0.6	1.1	3.9	-0.8	-0.9	-1.1	0.5	-0.6	0.5	0.2	-0.4	-2.0	-1.9
Frequency of depressed mood in last 2 weeks	0.9	1.2	6.8	-0.4	-1.1	-1.2	-0.1	-0.7	0.7	-1.0	-0.3	-2.6	0.7
Hearing difficulty/problems: Yes	0.7	1.1	2.8	1.6	0.8	1.3	-1.4	1.7	0.2	0.7	0.8	-0.1	-0.2
Relative age of first facial hair	0.6	1.2	2.6	1.4	1.3	1.6	0.0	1.1	0.5	1.6	0.8	0.1	0.9
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	6.2	-0.0	1.4	0.4	2.5	0.1	-1.1	1.7	0.7	0.4	0.2
Ever used hormone-replacement therapy (HRT)	1.0	1.3	3.7	1.4	0.6	1.9	-1.9	1.0	-1.1	-0.7	0.3	-0.1	0.8
Ever had hysterectomy (womb removed)	0.7	0.8	5.9	0.1	0.8	0.5	0.5	0.1	-0.3	-0.4	-0.7	2.4	-0.5
Systolic blood pressure, automated reading	1.8	5.1	10.4	2.3	2.6	3.0	-3.2	2.2	0.1	1.6	2.2	-1.9	-1.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	-0.7	-0.4	-0.6	1.6	-0.5	0.9	1.4	-0.1	-0.9	-1.1
Angina	4.7	6.2	15.7	3.3	4.0	3.5	0.4	3.0	-1.3	1.0	3.2	-0.0	-1.1
Medication for hormone replacement therapy	1.0	1.1	2.7	1.4	1.1	1.5	-0.4	1.6	0.6	1.0	-0.8	0.4	0.6
Vitamin and mineral supplements	2.2	3.0	7.4	-2.2	-2.5	-2.6	-1.5	-2.7	-0.1	-1.1	1.2	-0.2	-0.4
Supplements: Zinc	1.2	1.3	7.7	-0.3	1.1	0.0	0.7	0.5	-2.8	1.6	1.0	0.3	0.1
Medication: Co-codamol	0.7	0.8	2.1	1.5	1.1	1.3	0.1	0.8	-0.7	0.9	0.8	-0.2	-0.8
Medication: Metformin	1.9	2.7	5.7	-2.4	-1.7	-2.1	1.5	-2.3	-0.9	0.4	-1.1	0.6	-1.9
Diabetes (father)	2.0	2.5	5.6	-2.0	-2.4	-1.3	1.7	-2.0	1.5	-0.1	-0.9	1.3	1.4
Diabetes (mother)	1.0	1.3	4.1	-1.6	-1.5	-1.3	-0.0	-2.0	-0.0	0.2	-0.6	1.3	-0.7
Severe depression (siblings)	0.4	0.5	2.2	-0.2	0.0	0.6	-1.5	0.2	-0.1	-0.1	-0.3	-1.4	-0.2
Pack years adult smoking proportion	1.0	1.5	4.9	-1.0	-1.8	-2.2	0.8	-1.4	-1.0	0.1	-0.8	-1.0	-0.4
Impedance of leg (right)	0.6	2.9	7.1	1.4	1.5	2.7	0.5	2.0	0.2	2.0	1.3	-1.4	2.4
Leg fat-free mass (left)	0.7	3.7	20.2	-1.0	-1.1	-2.8	1.6	-1.8	0.4	-0.8	0.2	0.6	-4.5
Trunk fat percentage	1.2	4.8	14.1	2.5	2.5	1.2	2.0	1.7	0.9	1.0	1.3	-3.8	-3.0
Hand grip strength (right)	0.6	1.6	4.2	-0.1	-1.7	-0.2	0.0	-0.5	1.5	-1.5	-1.9	0.8	-2.0
Townsend deprivation index at recruitment	0.5	0.7	2.4	0.5	-0.4	-0.1	0.4	-0.5	-1.3	0.7	1.2	0.0	-1.6
Current tobacco smoking	0.8	1.3	3.3	-0.8	-1.8	-1.1	-0.0	-1.7	-1.0	0.6	-0.8	-0.8	1.4
Average weekly fortified wine intake	1.2	1.4	2.1	0.5	1.4	1.3	0.8	1.1	-1.3	1.5	0.9	-1.1	1.4
Maternal smoking around birth	0.7	1.0	2.1	-1.4	-0.7	-1.3	-0.7	-0.7	-1.4	0.5	-0.5	-0.3	-1.4
Fed-up feelings	0.2	0.4	1.3	-0.4	-0.6	-0.3	1.1	-0.5	0.3	0.7	0.4	-0.5	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.4	0.9	0.4	0.5	1.0	0.5	0.2	0.5	1.6	-1.5	-0.3
Relative age voice broke	0.8	1.2	3.9	0.2	0.5	0.7	1.1	1.1	0.9	1.8	-0.1	0.9	2.0
Taking other prescription medications	1.3	2.0	4.6	2.1	2.1	1.5	-0.7	1.7	-0.7	0.7	1.8	-0.0	-1.0
Age when periods started (menarche)	0.4	0.9	4.2	-0.3	-0.6	-0.9	-0.8	-1.1	-0.3	0.0	0.0	1.1	2.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	-0.8	-0.4	0.3	-0.2	-0.6	-0.0	-0.8	-0.9	-1.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	3.0	-0.4	-1.5	-0.2	-1.1	-1.6	-0.9	-1.7	-0.0	0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.5	-0.7	-0.6	0.0	0.2	-0.5	0.2	-0.1	0.4	0.1	-0.3
Qualifications: CSEs or equivalent	0.6	0.8	3.8	-0.9	-1.9	-0.6	-0.8	-0.9	-0.3	-0.8	-0.4	-1.1	0.0
Serious illness, injury or assault to yourself	1.1	1.3	4.5	0.3	0.8	1.2	-1.3	0.7	-1.2	1.6	2.1	0.2	0.5
High blood pressure	1.0	2.8	6.4	0.2	1.7	1.4	-0.7	0.5	1.1	1.9	2.2	-2.5	-2.5
Hayfever, allergic rhinitis or eczema	0.6	1.4	4.5	0.8	0.6	0.3	2.1	0.5	-1.7	0.1	0.4	-0.7	-2.1
Multivitamins +/- minerals	1.8	2.3	6.9	2.0	2.1	2.1	1.3	2.6	-0.2	0.3	-1.0	-0.5	0.1
Stomach or abdominal pain in last month	0.7	0.9	2.3	1.1	0.3	0.8	-0.7	1.0	0.2	1.1	-1.3	-1.5	-0.6
Supplements: Glucosamine	1.4	1.9	4.5	1.6	1.9	1.3	-0.3	2.1	0.8	1.0	0.2	1.6	1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.1	0.3	0.5	0.3	-0.6	-0.6	-0.7	1.4	1.0	-0.3	0.5
Medication: Atenolol	1.0	1.3	5.8	-0.2	0.2	0.2	-0.4	-0.8	0.0	-1.5	1.7	-1.0	-2.4
Medication: Levothyroxine sodium	0.5	0.9	3.2	1.2	0.6	1.1	-0.7	0.9	-0.2	1.8	0.7	-0.6	-0.4
Sitting height	0.8	5.4	13.0	3.6	2.8	2.7	0.2	3.4	-1.1	1.3	2.6	-0.5	-2.2
Chronic bronchitis/emphysema (father)	0.7	0.8	3.7	0.0	0.4	0.5	-1.9	0.2	1.1	0.0	-1.4	-0.2	-0.8
High blood pressure (mother)	0.4	0.6	1.8	-0.3	0.6	0.8	1.1	-0.1	-0.6	0.6	0.9	-0.4	-1.4
Body mass index (BMI)	0.5	1.9	7.7	-0.5	-0.6	-1.9	0.6	-1.3	1.4	-1.1	0.0	-1.4	-2.8
Impedance of leg (left)	1.0	5.0	11.7	2.2	2.3	3.4	0.6	2.7	0.1	2.6	1.8	-2.7	1.8
Leg predicted mass (left)	0.7	3.9	21.0	-1.1	-1.2	-2.9	1.4	-1.8	0.5	-0.8	0.3	0.6	-4.6
Trunk fat mass	0.8	3.4	12.7	1.7	1.6	0.1	2.0	0.9	0.9	0.7	1.1	-2.9	-3.6
Waist circumference	0.7	2.7	13.1	-0.7	-1.0	-2.5	1.6	-1.5	0.8	-0.2	0.2	-0.9	-3.6
Number of incorrect matches in round	1.2	2.0	5.2	-1.2	-1.7	-1.2	-2.3	-1.1	1.3	-1.3	-0.6	-0.0	-2.0
Past tobacco smoking	0.3	0.6	2.7	0.2	0.6	0.4	0.9	-0.3	-0.5	0.9	0.4	-1.6	0.7
Alcohol usually taken with meals	1.7	2.7	7.4	1.9	2.7	1.7	0.9	2.7	-0.8	1.2	0.4	-0.2	1.6
Nervous feelings	0.4	0.7	2.1	-0.1	-0.3	1.2	0.5	0.7	0.1	-1.1	-0.7	-1.5	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	2.0	0.1	-0.7	0.2	0.9	-0.1	1.2	-0.0	-0.1	-1.4	1.1
Hearing difficulty/problems with background noise	0.7	1.1	4.0	0.5	0.6	0.5	-0.4	1.4	-0.4	0.4	1.0	-1.8	-2.0
Hair/balding pattern: Pattern 2	1.8	2.3	12.0	1.3	1.2	1.0	0.9	1.6	-1.2	1.4	0.3	-3.5	-0.2
Had menopause	2.0	2.5	6.5	2.5	1.7	2.2	-0.7	2.4	-1.3	-0.3	-0.1	1.4	1.0
Had other major operations	0.4	0.5	1.5	0.2	0.2	-0.8	0.4	0.2	-1.1	0.3	1.2	-0.6	0.8
Forced vital capacity (FVC)	0.4	1.4	3.2	-0.9	-0.7	-1.2	1.7	-1.0	0.9	0.4	0.7	1.6	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.0	0.5	-0.6	0.9	-0.2	-0.5	-0.6	-1.4	-0.5	-0.7	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.2	-0.5	0.2	-0.0	0.7	0.0	0.1	-0.4	0.2	-0.1	1.1
Qualifications: None of the above	1.8	3.9	10.6	-1.2	-1.9	-1.5	-2.7	-2.1	-1.4	-1.9	0.2	-2.0	-3.3
Financial difficulties in last 2 years	1.5	2.0	5.9	-1.5	-1.0	-2.4	1.1	-1.8	1.1	-0.5	1.7	-0.2	-1.3
Mouth/teeth dental problems	0.8	1.2	3.4	1.5	1.3	1.0	-0.2	1.9	0.9	-0.2	-0.7	-0.9	1.5
Heart attack	1.4	1.8	4.8	1.3	1.8	1.7	-0.2	1.3	-0.6	1.4	2.2	0.9	0.9
Allergy	0.3	0.7	2.4	-0.4	-0.3	-0.0	-1.5	-0.1	1.6	-0.8	-0.6	0.8	0.8
Pain all over the body in last month	1.4	1.5	6.2	-1.2	-0.6	-1.1	2.5	-1.0	0.9	-0.6	-1.3	0.8	0.7
Diabetes (self-reported)	0.6	1.0	2.2	-1.4	-1.0	-1.3	0.4	-1.5	0.3	0.4	-0.8	1.3	0.4
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.6	0.8	0.2	0.1	0.3	-0.2	-0.9	1.2	0.4	-0.6	0.0
Medication: Ramipril	1.6	2.1	4.1	1.4	1.6	2.0	0.5	1.9	-0.3	0.3	2.0	-1.7	-1.0
Medication: Simvastatin	0.9	1.3	4.3	1.4	1.2	2.1	0.6	0.8	1.2	-1.4	0.7	-0.7	0.6
Fluid intelligence score	2.4	4.9	15.8	1.8	3.0	2.1	0.7	2.8	-0.3	4.0	1.4	1.8	1.9
Illnesses of siblings	2.1	2.9	6.0	-1.1	-2.0	-2.4	1.2	-1.9	-0.1	-2.4	-2.3	1.2	0.5
Neuroticism score	0.6	1.3	4.8	0.7	0.1	0.7	2.1	0.9	-0.3	0.2	-0.3	-2.2	-1.2
Weight	0.6	2.8	16.8	-0.0	-0.2	-2.0	1.8	-0.9	1.2	-0.1	0.7	-1.0	-4.1
Impedance of arm (right)	1.9	9.0	17.2	3.8	4.1	3.9	1.9	4.1	-0.8	3.0	2.5	-1.6	2.0
Arm fat percentage (right)	0.5	1.8	4.3	1.7	1.4	0.1	1.4	0.9	1.3	0.6	1.1	-2.1	-1.8
Trunk fat-free mass	0.8	4.7	12.8	-2.1	-2.2	-3.6	0.7	-2.8	0.8	-1.3	0.2	2.1	-3.2
Hip circumference	0.6	2.4	8.3	2.0	1.9	0.1	1.1	1.1	1.3	0.1	1.5	-1.3	-2.9
Time employed in main current job	0.8	0.9	3.1	0.8	1.3	1.2	0.2	1.8	0.4	-0.3	-1.1	-0.2	0.6
Alcohol intake versus 10 years previously	0.3	0.5	2.7	-0.6	-0.3	0.2	0.4	-0.7	-0.7	0.2	-0.5	-1.6	-0.3
Father’s age at death	0.6	0.8	3.0	0.7	0.9	1.0	-0.4	1.1	0.3	0.6	0.7	0.7	1.7
Worrier / anxious feelings	0.4	0.8	2.7	0.4	-0.6	0.3	1.7	-0.1	1.0	-0.5	-0.8	-0.8	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.1	0.3	0.1	-0.2	1.4	0.0	-1.1	0.6	0.4	-0.1	1.2
Falls in the last year	0.5	0.7	3.4	-0.6	1.0	-0.5	0.7	-0.3	1.8	-0.7	0.4	0.8	-0.0
Hair/balding pattern: Pattern 3	0.4	0.6	2.5	-0.1	0.5	-0.2	-0.4	-1.1	-0.6	0.2	0.9	1.6	-0.7
Number of live births	1.0	1.5	4.3	-0.7	-1.2	-1.1	0.9	-1.2	-1.5	-1.5	-0.5	-0.4	2.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.4	-0.8	-1.0	-1.5	1.2	-0.8	1.1	0.3	0.7	0.9	-1.5
Pulse rate	0.3	0.5	1.5	-0.6	0.2	0.6	0.1	-0.4	0.6	1.2	-1.0	-0.1	1.0
Happiness	0.4	0.5	2.0	0.9	-0.0	0.1	0.6	0.9	-1.4	-0.4	0.1	0.9	-0.0
Noisy workplace	0.4	0.5	1.6	-0.3	-1.3	-0.5	0.3	-0.7	-0.1	-1.1	-0.4	-1.3	0.0
Qualifications: A levels/AS levels or equivalent	0.8	1.9	4.0	1.3	1.3	1.0	0.9	1.8	-0.6	2.0	1.1	0.8	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.6	0.3	1.2	0.7	0.4	0.3	-1.1	1.0	0.9	0.0	-1.1
Mouth/teeth dental problems: Dentures	0.2	0.3	1.2	-0.2	-0.9	-0.5	-0.1	-1.1	0.1	-0.5	-0.2	0.1	-0.6
Asthma	0.3	0.7	1.3	1.0	1.1	1.0	0.6	0.8	-0.2	1.1	0.9	-0.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.6	0.1	-0.0	-0.1	-0.1	-0.4	0.4	-0.3	-0.7	0.8	0.6
Medication: Cholesterol lowering	0.8	1.2	4.5	1.1	1.4	2.1	0.2	0.4	-0.2	-1.1	1.2	1.0	-0.6
Depression (self-reported)	0.7	0.8	4.0	0.3	0.3	0.6	0.6	-0.0	0.6	-0.2	1.2	-2.0	-1.2
Medication: Lansoprazole	1.3	1.4	3.8	-1.1	-1.2	-1.4	-0.2	-1.9	1.0	-1.6	-0.9	1.1	0.1
Prospective memory result	2.2	2.7	10.8	0.7	-0.3	-0.8	-1.3	-0.2	1.0	-3.3	-1.9	-1.4	-2.6
Lung cancer (father)	2.9	3.4	9.5	-2.0	-3.0	-2.5	0.5	-3.1	-0.2	-1.8	-1.2	-0.5	-0.6
Illnesses of mother	1.0	1.2	6.0	0.1	-1.0	-0.4	-0.4	0.2	-0.8	-0.8	-1.4	-1.2	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.7	0.1	-0.3	-0.9	1.6	0.0	1.3	0.7	1.6	1.0	-1.2
Pulse wave Arterial Stiffness index	1.2	1.4	5.8	-0.8	-1.1	-1.4	1.2	-1.2	1.1	-0.1	-0.8	-0.1	-2.4
Impedance of arm (left)	2.0	9.2	19.2	3.8	4.1	4.2	1.3	4.4	-1.5	3.0	2.1	-2.3	1.5
Arm fat mass (right)	0.4	1.7	7.5	0.9	0.6	-0.7	1.4	0.1	1.6	0.1	0.6	-1.8	-2.7
Trunk predicted mass	0.9	4.9	13.6	-2.2	-2.3	-3.7	0.7	-2.9	0.8	-1.4	0.2	2.1	-3.2
Standing height	0.3	2.6	9.3	1.2	0.9	-0.1	2.7	0.8	-0.4	1.7	1.8	0.7	-3.0
Length of working week for main job	0.8	0.9	2.7	0.7	-1.0	-0.3	-1.3	-0.5	-0.5	-1.0	0.2	-1.6	-1.2
Exposure to tobacco smoke at home	0.9	1.0	4.6	-0.8	-1.2	-0.8	-2.2	-0.9	0.8	0.5	0.2	0.1	-1.1
Breastfed as a baby	1.1	1.3	4.1	-1.3	0.0	-0.9	1.2	-1.1	-2.0	1.0	1.1	1.3	0.3
Tense / ‘highly strung’	0.6	1.0	2.5	1.2	0.5	0.8	1.0	1.2	-0.3	-0.5	-1.6	-1.0	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	7.3	0.6	-0.5	0.6	-0.1	0.5	0.5	0.1	-0.5	-2.7	1.0
Hair/balding pattern: Pattern 4	1.0	2.5	13.8	-0.2	-1.0	-1.0	0.2	-0.4	-0.7	-1.9	-2.1	0.6	-3.7
Birth weight of first child	0.6	1.0	3.3	-0.7	-0.5	-1.8	1.8	-1.0	-0.6	-1.2	-0.3	-0.4	-0.2
Peak expiratory flow (PEF)	0.2	0.6	2.9	-0.4	-0.4	-0.4	-0.1	0.3	1.1	0.3	0.8	-0.6	-1.7
Pulse wave reflection index	0.7	0.8	2.0	-1.3	-1.0	-1.1	1.4	-1.0	-0.7	0.4	0.1	0.6	0.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.2	-1.2	0.3	-1.5	1.1	-1.2	-1.1	0.0	0.8	1.0	-0.2
Loud music exposure frequency	0.8	0.9	3.9	0.9	0.4	0.9	-2.0	0.8	-1.3	-0.2	-0.8	0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.2	0.1	0.2	0.6	0.5	0.8	1.4	1.5	0.8	0.3	0.8
Mouth/teeth dental problems: Bleeding gums	3.3	4.2	14.7	-3.8	-1.9	-3.0	0.0	-3.2	-0.6	0.5	0.4	1.5	-1.3
Blood clot in the leg (DVT)	0.5	0.7	3.2	-0.7	-0.7	-0.7	-0.4	-0.8	-0.9	0.4	1.8	-0.5	-0.2
Medication: Paracetamol	0.4	0.7	3.0	0.1	0.5	-0.1	1.5	0.0	0.4	-0.5	-1.0	-0.7	-1.7
Headache pain in last month	1.2	2.0	8.4	1.2	0.2	0.4	2.9	1.2	-1.8	0.4	-1.2	-2.1	-0.0
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	3.2	-1.1	-1.3	-1.8	0.1	-0.8	-0.1	0.5	-0.8	-0.5	1.2
Glaucoma (self-reported)	0.8	0.9	5.1	-0.4	0.5	0.1	-1.3	0.1	1.4	0.4	2.3	0.3	0.3
Gout (self-reported)	0.7	0.9	4.4	-0.3	-0.2	-0.1	-0.4	-0.4	0.6	-0.7	-0.1	1.8	2.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	3.6	1.3	-0.4	0.9	-1.9	0.2	-0.8	0.8	1.1	-1.7	-1.4
Medication: Amlodipine	0.5	0.7	1.9	-1.4	-0.2	-0.7	0.3	-1.2	-0.2	-0.7	0.0	-1.0	1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.4	0.0	0.5	0.3	-0.1	-0.0	-1.6	0.9	0.7	-0.2	-0.6
Birth weight	0.3	0.6	1.9	0.7	-0.2	0.4	0.4	1.4	0.6	0.8	0.5	-1.0	1.1
Chronic bronchitis/emphysema (mother)	1.8	2.0	8.9	0.1	0.9	0.5	-2.0	0.2	0.1	2.4	3.0	0.4	0.5
High blood pressure (siblings)	1.7	2.4	6.1	0.7	1.4	1.5	-0.9	1.2	-0.4	2.5	2.3	-2.3	-0.7
Forced vital capacity (FVC), Best measure	0.5	1.7	3.9	-0.6	-0.8	-1.2	2.0	-0.9	1.2	0.7	1.2	1.8	-1.8
Body fat percentage	1.0	4.0	11.8	2.4	2.1	0.9	1.6	1.6	1.1	1.1	1.4	-3.4	-2.8
Leg fat percentage (right)	0.3	1.2	3.5	1.2	0.5	-0.2	0.9	0.3	1.6	0.5	0.7	-1.9	-1.6
Arm fat-free mass (right)	0.8	4.2	17.6	-2.0	-1.7	-3.0	0.4	-2.4	0.7	-1.0	-0.1	0.4	-4.2
Exposure to tobacco smoke outside home	0.6	0.9	4.6	-0.2	0.1	-0.2	1.1	-0.6	0.1	-1.4	0.5	0.4	-2.1
Comparative body size at age 10	1.3	3.6	19.6	-0.4	-0.5	-1.1	-0.5	-0.2	2.3	-2.4	-0.0	-1.8	-4.4
Number of full brothers	0.3	0.4	1.7	-0.0	-1.3	0.1	-0.2	-0.3	0.7	0.9	-0.0	0.9	-0.5
Worry too long after embarrassment	0.5	0.9	6.0	-0.9	0.3	-0.1	2.5	0.0	-0.3	-0.8	-1.1	0.5	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.2	1.0	1.3	1.5	-0.1	0.8	0.4	1.0	0.3	-1.2	0.2
Wheeze or whistling in the chest in last year	1.1	2.0	4.9	2.1	2.2	1.6	1.2	1.4	-1.1	1.2	1.4	0.3	-0.7
Number of children fathered	0.9	1.0	3.7	0.4	0.0	0.0	-1.2	-0.6	0.0	-1.9	-0.4	1.4	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.2	3.2	1.4	0.7	1.8	0.2	1.0	-1.8	-0.7	-1.0	0.8	0.8
Age at first live birth	0.9	1.5	6.2	0.2	0.9	0.4	-0.6	1.4	1.8	0.8	-0.5	2.5	1.3
Pulse wave peak to peak time	1.2	1.4	5.0	0.9	1.2	1.4	-1.0	1.2	-1.1	0.4	0.8	0.2	2.2
Health satisfaction	1.2	1.6	4.8	1.7	0.7	0.7	1.8	1.5	-0.2	0.8	-0.0	-1.0	-2.2
Shortness of breath walking on level ground	0.9	1.1	2.1	1.2	1.2	1.5	0.5	0.6	-1.0	0.6	1.4	-0.9	-0.9
Qualifications: College or University degree	1.0	3.3	7.1	1.6	2.1	2.4	0.9	2.3	-0.1	1.8	1.3	1.4	2.7
Eye problems/disorders: None of the above	0.9	1.1	4.1	1.4	1.1	2.0	0.7	1.3	-0.4	-0.2	0.3	-0.7	-0.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.6	-0.4	0.0	0.0	-1.9	-0.6	-1.5	-0.2	1.2	2.4	-1.1
Emphysema/chronic bronchitis	0.6	0.6	3.0	-0.5	0.4	-0.4	0.9	-0.2	-0.2	1.4	-0.1	0.1	1.7
Medication for pain relief, constipation, heartburn	0.4	0.7	3.6	-0.7	-0.7	-0.7	-0.8	0.0	-0.0	0.4	0.3	1.1	1.9
Neck or shoulder pain in last month	0.6	0.9	4.5	0.7	0.9	0.6	0.4	0.2	-1.1	-0.0	0.5	-2.1	-0.9
Medication: Blood pressure	0.3	0.5	1.2	0.3	0.8	1.1	-0.5	0.5	0.6	-0.5	0.8	-0.5	-0.8
Angina (self-reported)	4.8	6.3	15.8	3.4	4.0	3.4	0.7	3.1	-1.3	1.0	3.0	-0.1	-1.4
Migraine (self-reported)	1.9	2.4	5.3	-2.3	-0.9	-2.3	2.3	-1.7	0.8	0.6	-0.5	-1.0	-1.5
Medication: Ibuprofen	0.2	0.3	0.9	-0.1	-0.1	-0.2	-1.0	-0.5	0.4	-0.4	-0.4	0.7	0.8
Medication: Allopurinol	0.4	0.5	1.5	0.8	0.8	0.8	-0.6	0.3	-0.6	-0.3	0.5	1.2	0.5
Medication: Omeprazole	0.5	0.5	3.7	0.3	0.0	0.2	0.3	-0.6	0.4	-0.7	-0.7	-0.1	-1.9
Medication: Seretide 50 evohaler	0.2	0.3	0.9	0.7	-0.3	0.2	-0.5	-0.0	0.4	0.2	0.5	-0.8	-0.9
Mean time to correctly identify matches	0.1	0.2	0.6	0.2	0.5	0.0	-0.7	0.2	0.1	0.2	0.8	0.7	0.7
Heart disease (mother)	1.0	1.2	8.5	0.9	0.6	0.7	-0.6	0.7	0.4	-0.2	-0.1	0.8	-2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.6	5.1	1.4	2.2	1.7	0.8	1.6	-0.1	0.2	-0.2	-1.6	-0.4
Whole body fat mass	0.7	2.9	11.9	1.7	1.4	0.0	1.7	0.8	1.2	0.7	1.1	-2.3	-3.4
Leg fat mass (right)	0.5	1.7	8.8	0.7	0.2	-0.9	1.4	-0.2	1.5	0.0	0.7	-1.7	-3.0
Arm predicted mass (right)	0.9	4.5	18.2	-2.2	-1.9	-3.1	0.5	-2.5	0.9	-1.1	-0.1	0.6	-4.3
Pulse rate, automated reading	0.2	0.8	2.8	-0.2	-0.0	-0.7	1.7	-0.9	-1.0	0.0	-0.9	-1.3	-0.3
Alcohol intake frequency.	1.0	2.3	15.0	0.6	0.3	0.1	1.1	0.5	-0.6	-0.3	1.3	-3.9	-1.8
Comparative height size at age 10	0.3	1.8	11.5	-0.2	-0.3	-1.3	1.5	0.3	-0.1	1.3	0.8	0.1	-3.4
Number of full sisters	0.3	0.4	1.1	0.5	0.5	0.7	1.0	0.4	0.1	0.7	0.4	-0.9	0.4
Suffer from ‘nerves’	0.7	1.1	4.9	0.5	-0.7	1.0	0.3	0.7	1.2	-0.8	-0.1	-2.2	-1.2
Overall health rating	0.2	0.5	1.8	0.1	0.5	-0.3	1.3	-0.5	-0.5	-0.0	0.7	0.6	-1.0
Chest pain or discomfort	2.2	3.2	9.1	1.5	3.0	1.1	2.0	1.4	-1.4	2.4	2.2	-0.8	-0.8
Had major operations	1.1	1.3	4.9	0.6	1.4	0.1	-0.2	0.7	-1.2	2.2	1.2	1.2	1.0
Age at last live birth	0.7	1.1	3.1	0.7	1.1	0.9	0.7	1.4	0.4	0.8	-0.2	1.4	1.8
Family relationship satisfaction	0.8	0.9	4.5	0.4	-0.2	-0.4	2.1	-0.1	-1.6	0.1	-1.1	0.4	-0.7
Leg pain on walking	0.6	0.8	4.3	0.7	0.1	-0.1	-0.5	-0.2	1.0	-2.1	-0.5	-0.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	5.2	-1.4	-1.8	-2.0	1.1	-2.3	0.8	-1.1	-1.1	-0.2	-0.5
Commuting to job workplace: Car/motor vehicle	1.2	1.4	5.8	-1.6	-0.7	-1.0	0.9	-1.1	0.2	-1.0	-2.4	-0.4	0.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.5	0.2	-1.1	-0.4	-0.7	0.0	0.5	-1.3	-1.9	0.4	0.7
Medication: Aspirin	2.1	2.8	6.6	2.1	2.3	2.6	0.8	1.7	-0.6	1.0	1.2	-1.3	-1.9
Supplements: Vitamin C	1.1	1.3	3.1	0.5	1.3	1.5	1.8	1.0	-1.1	-0.1	-1.2	-1.3	-0.5
Knee pain experienced in last month	0.8	1.2	4.4	0.9	0.8	-0.5	0.4	-0.0	2.1	-0.6	-1.3	0.4	-1.9
Hypertension (Self-reported)	0.7	2.0	5.4	0.1	1.5	1.3	-0.1	0.1	0.8	1.6	1.6	-2.3	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.9	2.7	-1.0	-1.2	-1.1	0.7	-0.6	1.6	-1.1	-0.5	0.5	0.0
Illnesses of father: Heart disease	3.0	4.2	15.1	3.0	3.9	2.8	-0.5	2.7	0.0	-0.1	0.5	-1.3	-0.9
Illnesses of siblings: Diabetes	1.1	1.3	3.7	-1.1	-0.8	-1.0	-0.0	-0.9	1.9	0.8	0.3	1.4	-1.8
Smoking status: Previous	0.6	0.9	3.2	-0.5	-0.4	-0.6	-1.1	-0.1	0.6	-1.5	0.1	1.0	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	4.9	0.9	0.5	-0.1	0.3	0.0	-0.3	0.5	2.2	-0.0	-0.7
Whole body fat-free mass	0.8	4.6	15.8	-1.8	-1.9	-3.5	1.1	-2.6	0.7	-1.1	0.2	1.4	-4.0
Leg fat-free mass (right)	0.7	3.7	22.8	-0.9	-0.8	-2.7	1.6	-1.6	0.4	-0.7	0.3	0.2	-4.8
Arm fat percentage (left)	0.5	1.9	6.5	1.4	1.3	0.0	1.2	0.8	1.0	0.6	0.8	-2.6	-2.2
Average weekly red wine intake	0.5	0.8	3.6	0.5	0.2	0.5	-1.1	0.8	-0.1	1.1	1.9	0.5	0.0
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.3	-0.3	0.3	-0.1	0.2	-0.2	-0.9	-1.1	-1.3	1.5	1.3
Mood swings	0.2	0.4	2.2	0.3	-0.1	0.5	1.1	0.2	0.1	0.4	0.3	-1.5	-0.4
Loneliness, isolation	1.2	1.7	4.5	-1.7	-0.5	-2.1	2.1	-1.9	-0.5	0.1	-0.7	-0.7	0.3
Long-standing illness, disability or infirmity	0.5	0.7	2.3	1.4	1.5	1.0	-0.3	0.2	-0.9	0.7	0.6	0.1	-0.6
Ever had bowel cancer screening	0.5	0.6	3.8	-0.8	0.1	-0.5	-0.1	-0.9	-0.2	-0.8	0.4	1.9	-0.0
Diabetes diagnosed by doctor	0.9	1.5	4.8	-1.9	-1.6	-1.8	0.4	-2.2	-0.3	0.1	-0.7	0.2	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.3	0.3	1.0	0.2	0.1	0.5	-1.5	1.4	-0.3	0.7	-0.1
Friendships satisfaction	0.4	0.5	1.4	1.0	0.4	0.4	0.8	1.2	-0.9	-0.1	0.1	-0.3	-0.5
Qualifications: nursing, teaching	3.6	5.7	16.4	4.0	3.4	2.4	1.5	4.0	1.2	1.0	-0.2	1.0	1.0
Commuting to job workplace: Walk	1.1	1.2	4.3	0.7	1.4	1.5	-0.9	1.0	0.4	0.8	2.1	0.7	0.7
Eye problems/disorders: Cataract	0.5	0.6	2.2	-0.1	0.1	-0.6	-1.5	-0.3	-0.0	0.6	-1.5	0.5	0.7
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	3.7	1.7	0.6	1.9	0.3	1.2	0.2	-0.1	-0.3	-1.9	0.0
Medication for cholesterol	1.2	1.8	5.2	-0.8	-1.4	-1.3	-1.2	-0.6	-1.7	-0.9	-0.7	1.5	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.9	-0.3	-0.7	-0.5	-0.7	-0.4	0.0	-0.1	-0.9	-1.7	-0.8
Back pain experienced in last month	0.7	1.1	4.2	-0.8	0.2	-1.2	0.4	-1.4	0.8	-0.3	1.3	0.5	-2.1
Mineral and other dietary supplements	1.5	2.1	6.5	-1.6	-2.0	-1.6	1.3	-2.5	-0.8	0.1	-0.2	-1.6	0.1
Breast cancer (self-reported)	1.3	1.6	4.6	2.1	1.6	1.1	-0.2	1.6	-0.1	-1.4	-0.5	0.7	-1.4
Asthma (self-reported)	0.6	1.3	2.6	1.4	1.6	1.3	0.8	1.1	-0.3	1.4	1.3	-0.9	-0.3
Osteoporosis (self-reported)	0.3	0.4	1.7	0.1	0.5	-0.5	-0.9	0.0	0.4	-0.5	0.3	-0.4	-1.3
Osteoarthritis (self-reported)	1.1	1.5	6.8	0.6	1.2	-0.6	1.1	-0.0	2.1	-0.3	0.1	0.6	-2.6
Medication: Aspirin	1.5	2.0	5.2	1.6	1.6	2.0	0.4	1.3	-0.4	1.3	0.8	-1.2	-2.3
Medication: Gliclazide	2.0	2.3	7.3	-2.2	-1.9	-2.1	0.7	-2.7	-1.3	-0.2	-0.7	0.3	0.5
Illnesses of father: None of the above (group 1)	2.4	3.0	9.9	-2.0	-3.2	-2.8	1.5	-2.4	0.5	0.0	-0.3	-0.0	-0.7
Smoking status: Current	0.8	1.3	3.7	-0.8	-1.9	-1.2	0.4	-1.6	-0.7	0.7	-0.7	-0.6	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	4.0	-0.6	-0.4	-1.6	1.6	-1.3	0.0	-0.3	0.3	2.0	-0.5
Whole body water mass	0.8	4.3	15.9	-1.7	-1.7	-3.3	1.1	-2.4	0.7	-1.1	0.2	1.3	-4.0
Leg predicted mass (right)	0.7	3.7	21.8	-0.9	-0.9	-2.8	1.6	-1.6	0.4	-0.7	0.2	0.1	-4.7
Arm fat mass (left)	0.4	1.7	8.4	0.5	0.5	-1.0	1.3	-0.2	1.4	-0.0	0.6	-1.7	-2.9
Number of self-reported non-cancer illnesses	1.3	2.2	5.8	0.9	1.4	1.4	0.3	0.4	-0.8	2.0	2.4	-2.0	-1.7
Average weekly champagne plus white wine intake	0.6	0.8	2.5	-0.4	1.1	-0.3	1.4	-0.1	0.4	-1.6	-0.4	1.2	0.5
Miserableness	1.0	1.7	6.7	0.8	0.8	0.7	0.3	0.7	0.5	1.9	1.5	-2.6	-1.5
Guilty feelings	0.5	0.8	2.3	0.8	-0.2	0.3	1.3	0.2	1.4	-0.5	-1.5	0.6	-0.9
Wears glasses or contact lenses	1.2	1.4	4.8	2.1	1.0	1.0	0.6	2.2	1.3	-0.3	-0.5	0.1	0.1
Ever taken oral contraceptive pill	1.0	1.1	2.5	-1.2	-1.6	-1.5	-0.4	-1.3	1.2	-0.5	-0.7	-0.1	0.7
Hearing aid user	0.7	0.8	3.2	-0.1	-0.3	0.3	-0.3	0.2	0.8	1.4	1.1	0.0	1.8
Mother’s age at death	0.5	0.7	3.9	0.4	-0.2	0.6	-0.1	0.3	-1.3	0.2	0.5	0.2	2.0
Financial situation satisfaction	1.3	1.6	4.1	2.0	0.9	0.5	0.6	1.1	-0.4	-0.5	1.9	-1.5	-1.7
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.1	0.5	0.8	0.4	-1.0	1.0	-1.3	1.8	0.4	0.0	-0.5
Commuting to job workplace: Public transport	0.2	0.2	0.5	0.7	0.4	0.6	0.0	0.2	-0.2	0.7	0.7	-0.2	0.5
Eye problems/disorders: Glaucoma	0.5	0.6	2.5	-1.0	0.0	-0.8	-0.1	-0.6	1.2	0.6	1.6	0.1	-0.4
Medication: Blood pressure	0.9	1.6	4.6	-0.6	0.2	-0.5	1.4	-0.6	1.1	1.3	1.4	-2.0	-2.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	3.8	-0.3	-0.4	-0.6	-1.9	-0.7	0.6	-0.5	-0.0	-1.0	-0.8
Supplements: Fish oil (including cod liver oil)	1.2	1.5	3.7	1.4	1.7	1.4	-0.8	1.9	0.1	-0.5	0.6	0.3	-1.8
High cholesterol (Self-reported)	0.7	1.2	5.6	1.2	0.3	1.5	0.5	0.7	1.3	-2.4	0.0	-0.2	-0.3
Medication: Bendroflumethiazide	0.5	0.8	3.9	-0.8	0.0	-1.0	0.6	-0.5	2.0	0.6	1.1	-0.4	-0.7
Medication: Paracetamol	0.5	0.8	3.9	-0.2	0.1	-0.4	0.0	-0.4	0.5	-0.4	-1.5	-0.8	-2.0
Medication: Lisinopril	1.1	1.5	4.2	-1.7	-0.9	-1.2	-0.6	-2.1	0.9	1.1	1.6	0.4	0.5
Medication: Atorvastatin	1.1	1.3	4.1	-1.4	-0.7	-0.0	-0.2	-0.3	0.9	2.0	1.6	1.4	-0.9
Illnesses of father: High blood pressure	0.8	0.9	3.3	0.9	1.4	1.8	0.1	1.0	0.2	-0.1	0.5	-1.0	1.0
Alcohol drinker status: Never	0.3	0.3	0.7	-0.4	0.2	-0.3	0.8	-0.1	0.8	-0.7	0.9	-0.6	-0.1
Ever smoked	0.2	0.3	1.8	0.1	-0.5	-0.2	-0.4	0.1	0.2	-0.1	-0.3	1.4	0.6
Basal metabolic rate	0.7	4.1	17.1	-1.5	-1.5	-3.2	1.3	-2.2	1.0	-0.8	0.3	0.7	-4.1
Leg fat percentage (left)	0.5	1.9	6.5	1.4	0.8	0.1	1.0	0.6	1.5	0.7	0.9	-2.5	-2.1
Arm fat-free mass (left)	0.7	3.8	12.7	-1.7	-1.5	-3.1	0.8	-2.4	1.6	-0.7	0.4	0.9	-3.6
Number of operations (self-reported)	0.6	0.9	2.3	-0.5	1.2	-1.1	-0.8	-0.5	-0.2	0.0	1.4	1.1	1.5
Average weekly beer plus cider intake	1.5	2.1	5.0	-1.8	-2.2	-1.3	-1.5	-1.7	0.7	-1.2	-2.0	-0.2	-0.4
Irritability	0.4	0.6	3.2	0.1	0.4	-0.3	1.8	0.6	0.6	-0.2	-1.3	0.8	0.3
Risk taking	1.1	1.6	7.2	-0.6	-0.3	-0.4	0.1	-0.5	-1.7	1.4	2.7	0.3	1.7
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.0	1.2	1.2	0.6	1.7	1.1	-0.6	-0.1	-0.7	0.8	-0.4
Fractured/broken bones in last 5 years	0.5	0.7	2.2	-0.1	-0.4	-0.8	-1.0	0.1	1.1	-0.8	-0.6	-0.8	1.5
Age started oral contraceptive pill	1.4	1.8	4.5	2.1	1.7	1.4	-1.0	1.5	-1.6	-0.1	1.1	-0.6	0.9
Diastolic blood pressure, automated reading	0.5	1.7	6.3	0.2	1.0	1.3	-2.0	0.0	-0.7	0.9	0.9	-2.5	-1.3
Ever depressed for a whole week	0.5	0.6	3.5	-0.1	0.5	-0.1	-0.2	0.4	-0.1	0.5	1.9	0.4	1.2
Unable to work because of sickness or disability	0.2	0.3	1.5	-0.4	-0.1	0.1	-0.0	-0.6	0.4	-1.2	-0.0	0.4	-0.6
Commuting to job workplace: Cycle	0.9	1.0	3.1	0.2	0.2	0.6	-0.8	0.9	1.7	0.4	-0.9	1.3	1.8
Myopia	1.1	1.6	4.8	-1.2	-1.1	-0.8	2.2	0.1	0.5	0.7	-1.9	-1.0	-1.5
Vascular/heart problems diagnosed by doctor	1.3	3.6	9.6	-0.9	-2.6	-1.9	0.5	-0.9	-0.3	-2.0	-3.1	2.0	2.6
Cholesterol lowering medication	0.8	1.1	3.6	-0.7	-0.4	0.2	1.1	-0.3	1.9	-0.9	0.1	-1.7	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	3.1	0.6	0.4	0.2	1.3	-0.2	0.4	-0.4	-0.6	-0.4	-1.8
Pain experienced in last month	0.5	0.8	2.9	-0.3	0.1	0.9	-1.1	0.6	-0.5	0.5	0.5	1.7	1.4
Supplements: Calcium	0.9	1.0	3.1	0.9	1.1	0.9	0.1	1.8	0.8	0.9	-0.8	1.2	-0.8
Basal cell carcinoma (self-reported)	0.6	0.7	2.0	0.5	1.0	1.3	0.5	0.5	0.5	0.0	1.0	-0.8	1.4
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.9	1.3	1.7	1.6	-0.1	1.2	-0.6	1.3	2.2	0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	3.1	-0.5	-0.6	-0.6	-0.3	-0.8	-0.8	1.0	1.8	-0.6	-0.3
Heart disease (siblings)	0.8	1.0	2.0	0.6	1.0	1.3	-0.6	1.2	0.1	1.1	1.4	1.1	-0.9
Alcohol drinker status: Previous	0.7	0.8	4.9	0.2	0.0	0.1	0.7	0.4	0.3	-1.2	-0.6	-2.2	-0.9
Pack years of smoking	0.9	1.3	4.2	-1.0	-1.9	-2.0	1.0	-1.4	-0.5	-0.1	-0.9	-0.6	-0.2
Impedance of whole body	1.6	8.0	17.7	3.2	3.4	4.2	1.1	3.8	-0.8	3.0	1.9	-2.9	1.7
Leg fat mass (left)	0.6	2.2	11.0	0.8	0.4	-0.8	1.5	-0.0	1.4	0.1	0.7	-2.1	-3.3
Arm predicted mass (left)	0.7	3.6	12.0	-1.6	-1.6	-3.0	0.5	-2.4	1.3	-0.9	0.5	1.1	-3.5