Hub : Genes

MDN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.051	0.021	0.00220	0.031	0.013	0.034	0.016	0.027	1.1e-04	0.009	5.3e-05	0.0041	2.6e-04
2	GTEx	Artery Aorta	0.112	0.048	0.00810	0.013	NA	0.028	NA	0.053	5.8e-02	NA	1.0e-02	NA	6.6e-04
3	GTEx	Liver	0.296	0.095	0.00044	0.277	NA	0.250	NA	0.254	2.2e-08	NA	1.3e-07	NA	9.8e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.7	0.9	1.0	0.9	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.7	1.0	-0.2
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	0.3	0.9	-0.7
Depression (Nagel 2018)	0.7	1.1	1.7	-1.3	1.0	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	0.2	-0.1	1.1
Neuroticism (Nagel 2018)	0.2	0.5	1.2	0.3	0.5	-1.1
Schizophrenia (2018)	0.1	0.1	0.3	0.1	0.6	0.3
Schizophrenia vs Biploar Disorder	0.8	1.1	1.8	-1.3	0.8	0.9
Worry (Nagel 2018)	0.6	1.2	1.9	1.4	0.1	-1.4
Alzheimer’s Disease (in mother)	1.8	2.1	5.7	-0.4	-2.4	0.6
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.4	0.1	-0.2
Alzheimer’s Disease (including proxy)	0.6	0.8	2.4	0.1	-1.6	0.1
Crohns Disease (2017)	0.5	1.0	1.1	-1.1	1.0	1.0
Irritable Bowel Disease (IBD)	0.1	0.3	0.8	-0.4	0.9	0.2
Ulcerative Colitis (UC)	0.1	0.2	0.3	0.4	0.5	-0.4
Major Depression (MDD)	0.2	0.2	0.4	-0.5	0.6	-0.0
Reaction Time	1.2	2.2	3.4	-1.6	-0.7	1.8
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.6	0.5	0.8	0.5
Breast Cancer	0.4	1.1	3.2	-0.0	-1.8	0.3
Ovarian Cancer	0.4	0.6	0.9	0.8	-0.4	-1.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	0.7	-0.4	-0.6	0.8
Bipolar Disorder (2011)	0.4	0.4	0.9	-0.2	1.0	-0.4
Body Mass Index (BMI) (2010)	0.9	1.3	2.8	-1.7	0.0	1.1
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.2	0.3	-0.4
Crohns Disease (2012)	0.9	1.5	3.3	-0.9	0.5	1.8
Mean Putamen Volume	0.3	0.3	0.5	0.6	0.5	-0.7
Fasting Glucose	0.0	0.0	0.1	-0.3	0.1	0.2
HbA1C	0.7	0.7	1.2	-1.0	1.1	0.2
HDL Cholesterol	0.5	0.8	1.2	1.1	-0.3	-1.1
LDL Cholesterol	0.1	0.1	0.2	0.3	0.5	-0.4
Lupus	1.4	2.1	2.6	-1.5	-1.6	1.2
Neuroticism (2016)	0.6	0.9	1.0	1.0	1.0	-0.9
Primary Biliary Cirrhosis	2.4	3.4	3.8	2.0	1.9	-1.6
Rheumatoid Arthritis	2.8	3.8	9.8	-0.8	-3.1	1.0
Schizophrenia (2014)	0.3	0.7	2.2	0.0	1.5	0.1
Triglycerides	0.1	0.2	0.5	-0.7	-0.3	0.1
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.2	1.2	1.5	-1.3
Ulcerative Colitis	0.2	0.4	0.6	0.7	-0.1	-0.8
Blood Eosinophil Count	2.2	17.3	31.1	-4.5	-0.7	5.6
Blood Platelet Count	0.0	0.4	1.0	1.0	0.4	-0.4
Blood Red Count	0.3	2.4	5.4	0.8	2.3	-1.1
Blood White Count	0.8	6.0	9.8	-3.1	0.1	2.8
Heel T-Score	0.1	0.7	1.9	-1.4	0.5	0.3
BMI	1.3	7.8	12.7	-3.6	-2.0	2.6
Height	0.4	7.5	8.8	-3.0	-2.3	2.9
Waist Hip Ratio (WHR)	0.1	0.6	0.9	0.9	0.3	-0.8
Systolic Blood Pressure	0.7	3.6	5.5	2.3	0.8	-2.1
Smoking Status	0.1	0.3	0.8	-0.9	0.2	-0.2
Allergy or Eczema	0.3	0.7	0.8	0.9	-0.7	-0.9
Cardiovascular Disease	0.4	1.2	2.8	-0.9	-1.7	0.2
Hypothyroidism (self reported)	0.0	0.1	0.2	0.2	-0.1	0.5
Respiratory disease	0.0	0.1	0.1	0.2	0.3	-0.2
Type 2 Diabetes (T2D) (2018)	0.3	0.7	1.7	-0.3	-1.3	-0.4
Lung FEV1/FVC ratio	0.1	0.4	1.1	-0.1	-1.0	-0.1
Lung FVC	0.5	2.6	3.4	1.8	-1.2	-1.7
Neuroticism	0.5	1.3	2.0	1.3	0.5	-1.4
Chronotype (morning person)	4.1	9.4	13.3	3.7	1.5	-3.6
Hair Pigment	0.0	0.2	0.6	-0.3	-0.8	0.1
Tanning	0.0	0.1	0.1	-0.3	0.1	-0.3
Hand grip strength (left)	0.2	0.5	0.7	-0.8	0.5	0.8
Number of treatments/medications taken	0.3	0.6	1.0	-0.5	-0.8	1.0
Average weekly spirits intake	2.0	2.5	4.9	-0.9	-1.3	2.2
Sensitivity / hurt feelings	0.2	0.4	0.6	0.8	-0.1	-0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.2	-1.1	0.8	1.1
Hearing difficulty/problems: Yes	1.5	2.3	5.5	2.3	0.5	-1.0
Relative age of first facial hair	1.9	3.9	6.8	-1.2	-2.6	1.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.6	-0.1	-1.3	0.0
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.7	0.8	-0.9	-0.3
Ever had hysterectomy (womb removed)	1.4	1.6	2.7	1.3	0.7	-1.6
Systolic blood pressure, automated reading	0.6	1.6	2.0	1.4	1.4	-0.9
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.2	-0.6	-0.4
Angina	0.5	0.6	1.5	-0.4	1.2	-0.4
Medication for hormone replacement therapy	0.5	0.5	1.4	0.0	-1.2	0.4
Vitamin and mineral supplements	0.4	0.6	0.9	-0.9	0.3	0.9
Supplements: Zinc	0.4	0.5	1.0	-1.0	0.2	0.6
Medication: Co-codamol	0.7	0.8	2.0	-0.5	-1.4	-0.2
Medication: Metformin	0.2	0.2	0.7	0.0	0.1	-0.8
Diabetes (father)	4.0	4.9	5.6	-2.4	-2.1	2.2
Diabetes (mother)	0.1	0.1	0.2	-0.2	0.4	-0.4
Severe depression (siblings)	0.2	0.2	0.3	-0.1	-0.6	-0.5
Pack years adult smoking proportion	0.2	0.4	0.7	-0.2	0.6	0.8
Impedance of leg (right)	1.0	4.7	7.2	2.7	0.7	-2.5
Leg fat-free mass (left)	2.0	10.4	16.2	-4.0	-1.4	3.6
Trunk fat percentage	0.6	2.4	3.5	-1.9	-1.2	1.5
Hand grip strength (right)	0.1	0.3	0.5	-0.6	-0.0	0.7
Townsend deprivation index at recruitment	3.1	4.3	5.5	-2.4	-1.6	2.2
Current tobacco smoking	0.2	0.3	0.7	-0.8	-0.3	0.4
Average weekly fortified wine intake	1.7	2.0	2.3	1.4	1.3	-1.5
Maternal smoking around birth	0.1	0.2	0.4	0.0	0.3	-0.6
Fed-up feelings	0.1	0.1	0.3	0.0	0.6	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	-0.9	0.7	0.4
Relative age voice broke	1.1	1.7	3.1	-1.3	-0.4	1.8
Taking other prescription medications	0.5	0.7	0.9	0.8	1.0	-0.7
Age when periods started (menarche)	1.6	3.9	7.1	2.7	1.2	-1.8
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	2.8	1.5	0.1	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.1	-1.4	-0.6	0.6
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.9	-0.1	1.0	-0.5
Qualifications: CSEs or equivalent	0.1	0.1	0.2	0.4	0.1	0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.2	0.6	-0.1
High blood pressure	0.4	1.1	1.3	-1.1	-1.1	1.0
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.0	0.4	-1.7	-0.6
Multivitamins +/- minerals	0.0	0.0	0.1	-0.0	-0.2	-0.3
Stomach or abdominal pain in last month	1.6	2.0	2.7	-0.9	-1.6	1.6
Supplements: Glucosamine	0.3	0.4	0.7	0.4	0.6	-0.8
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.7	0.1	1.6	0.2
Medication: Atenolol	0.2	0.2	0.5	-0.0	-0.7	0.2
Medication: Levothyroxine sodium	0.3	0.5	1.0	1.0	0.7	-0.3
Sitting height	0.7	4.8	6.9	-2.5	-1.2	2.6
Chronic bronchitis/emphysema (father)	1.1	1.2	2.0	-0.9	-1.0	1.4
High blood pressure (mother)	4.9	6.8	8.9	-2.3	-2.6	3.0
Body mass index (BMI)	1.1	4.7	8.3	-2.9	-1.1	2.2
Impedance of leg (left)	0.6	2.8	4.3	2.1	0.4	-2.0
Leg predicted mass (left)	2.1	11.0	17.0	-4.1	-1.5	3.7
Trunk fat mass	1.1	4.9	8.0	-2.8	-1.4	2.2
Waist circumference	0.9	3.1	5.4	-2.3	-1.2	1.6
Number of incorrect matches in round	1.1	1.9	3.9	1.3	-0.2	-2.0
Past tobacco smoking	0.1	0.2	0.3	0.3	-0.3	0.5
Alcohol usually taken with meals	2.4	3.9	6.0	2.5	-0.2	-2.4
Nervous feelings	0.6	1.2	1.8	1.2	0.4	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	0.3	1.1	-0.3
Hearing difficulty/problems with background noise	1.9	3.0	6.2	2.5	0.6	-1.6
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.4	0.3	-0.4
Had menopause	0.9	1.2	2.4	0.6	1.5	-0.9
Had other major operations	0.6	0.7	1.0	0.8	-1.0	-0.7
Forced vital capacity (FVC)	0.3	1.2	3.2	0.4	-1.8	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	2.9	-1.7	-1.6	1.0
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.2	0.1	0.2	-0.4
Qualifications: None of the above	0.1	0.3	0.6	-0.4	0.1	0.8
Financial difficulties in last 2 years	0.5	0.6	1.0	-1.0	0.2	0.9
Mouth/teeth dental problems	0.1	0.1	0.2	-0.1	0.4	-0.3
Heart attack	1.1	1.3	3.7	-0.5	1.9	-0.3
Allergy	0.3	0.8	2.1	-0.1	1.4	0.4
Pain all over the body in last month	1.3	1.4	3.1	1.0	-0.3	-1.8
Diabetes (self-reported)	0.8	1.3	2.7	-1.1	-1.6	0.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.0	1.7	-0.3	-1.4
Medication: Ramipril	0.4	0.6	1.0	0.7	1.0	-0.6
Medication: Simvastatin	1.2	1.7	2.6	0.7	1.4	-1.6
Fluid intelligence score	0.6	1.2	2.3	1.1	1.5	-0.2
Illnesses of siblings	1.1	1.5	2.9	1.7	1.0	-0.8
Neuroticism score	0.7	1.4	1.6	1.1	1.2	-1.3
Weight	1.9	9.2	15.3	-3.9	-1.5	3.2
Impedance of arm (right)	0.8	3.9	7.2	2.7	0.8	-2.0
Arm fat percentage (right)	0.5	1.9	3.3	-1.8	-0.9	1.3
Trunk fat-free mass	1.3	7.3	13.7	-3.7	-0.7	2.8
Hip circumference	1.0	4.4	6.3	-2.5	-1.9	1.8
Time employed in main current job	1.3	1.5	2.0	-1.4	-0.8	1.4
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.5	0.0	0.8
Father’s age at death	0.9	1.1	2.8	1.7	-0.0	-0.8
Worrier / anxious feelings	0.6	1.2	1.8	1.3	0.8	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	2.6	-1.6	0.0	1.6
Falls in the last year	0.1	0.1	0.3	0.5	0.1	-0.2
Hair/balding pattern: Pattern 3	0.6	0.9	1.3	1.1	0.4	-1.1
Number of live births	0.3	0.5	0.8	-0.9	-0.2	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	2.0	1.0	-1.4	-0.8
Pulse rate	1.4	2.3	4.4	1.2	2.1	-1.1
Happiness	0.4	0.5	1.3	-0.2	1.1	-0.1
Noisy workplace	1.0	1.3	3.3	-0.4	-1.8	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.7	-0.4	-0.8	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.1	-0.7	0.2	1.1
Mouth/teeth dental problems: Dentures	0.4	0.6	1.0	0.6	-0.7	-1.0
Asthma	0.1	0.2	0.5	-0.4	-0.3	0.7
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	8.5	-1.9	-1.8	2.9
Medication: Cholesterol lowering	0.2	0.4	0.8	-0.9	0.5	0.3
Depression (self-reported)	1.9	2.2	3.3	1.8	0.7	-1.7
Medication: Lansoprazole	1.3	1.5	2.1	-1.2	-1.5	0.9
Prospective memory result	0.1	0.1	0.2	-0.4	-0.2	0.2
Lung cancer (father)	1.1	1.3	1.5	-1.0	1.2	1.2
Illnesses of mother	2.0	2.5	4.2	1.1	2.1	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	1.0	1.0	-1.0	-0.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.4	0.5	-0.6	-0.4
Impedance of arm (left)	0.6	3.0	6.5	2.5	-0.1	-1.6
Arm fat mass (right)	1.3	5.5	9.4	-3.1	-1.3	2.3
Trunk predicted mass	1.4	7.9	14.7	-3.8	-0.7	2.9
Standing height	0.5	4.6	6.7	-2.6	-1.1	2.5
Length of working week for main job	0.2	0.3	0.4	-0.6	0.5	0.4
Exposure to tobacco smoke at home	0.6	0.7	1.1	1.0	-0.9	-0.5
Breastfed as a baby	0.1	0.2	0.4	0.7	0.1	-0.3
Tense / ‘highly strung’	0.2	0.3	0.5	0.6	0.7	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	5.9	2.4	0.7	-2.2
Hair/balding pattern: Pattern 4	0.7	1.6	1.8	-1.4	1.3	1.1
Birth weight of first child	0.2	0.3	0.5	0.6	-0.1	-0.7
Peak expiratory flow (PEF)	0.1	0.1	0.3	-0.1	-0.5	0.2
Pulse wave reflection index	2.9	3.5	3.6	-1.9	-1.9	1.9
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.1	0.9	-0.6
Loud music exposure frequency	0.1	0.1	0.1	0.3	0.2	0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.0	-0.6	-1.0	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.9	0.7	0.2
Blood clot in the leg (DVT)	1.1	1.4	2.6	0.6	-1.6	-1.1
Medication: Paracetamol	0.9	1.5	3.8	0.6	-2.0	0.5
Headache pain in last month	0.2	0.3	0.7	-0.3	0.8	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.4	-0.2	-0.2
Glaucoma (self-reported)	1.1	1.3	3.5	0.2	1.9	-0.5
Gout (self-reported)	0.4	0.6	1.4	-0.1	-1.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	0.4	-0.2	-0.2
Medication: Amlodipine	1.0	1.4	2.7	-1.1	-1.6	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	0.9	-0.1	-0.5
Birth weight	0.0	0.0	0.0	0.0	0.1	-0.0
Chronic bronchitis/emphysema (mother)	0.5	0.5	0.9	0.8	0.2	-1.0
High blood pressure (siblings)	0.7	1.0	1.9	-1.4	-0.9	0.6
Forced vital capacity (FVC), Best measure	0.2	0.6	1.6	0.3	-1.3	-0.2
Body fat percentage	0.7	2.7	4.1	-2.0	-1.3	1.5
Leg fat percentage (right)	0.4	1.6	3.3	-1.8	-0.8	0.8
Arm fat-free mass (right)	2.2	11.1	19.1	-4.4	-1.6	3.4
Exposure to tobacco smoke outside home	0.5	0.7	1.2	-0.2	-1.1	0.9
Comparative body size at age 10	1.6	4.4	8.9	-3.0	0.1	2.1
Number of full brothers	0.5	0.6	1.5	0.5	-0.4	-1.2
Worry too long after embarrassment	0.1	0.2	0.4	0.0	0.6	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.6	-0.2	0.4
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.1	0.1	-0.2
Number of children fathered	0.4	0.4	1.1	0.4	0.1	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	4.9	1.0	-0.1	-2.2
Age at first live birth	0.4	0.7	1.0	-1.0	-0.9	0.6
Pulse wave peak to peak time	0.3	0.4	0.6	-0.8	0.5	0.5
Health satisfaction	0.7	0.9	1.3	0.4	1.1	-1.1
Shortness of breath walking on level ground	5.6	6.6	10.4	3.2	1.5	-2.7
Qualifications: College or University degree	0.1	0.2	0.5	-0.0	-0.7	-0.3
Eye problems/disorders: None of the above	1.5	1.7	4.2	0.6	-2.0	0.7
Mouth/teeth dental problems: Loose teeth	1.9	2.3	4.2	-1.6	-0.3	2.0
Emphysema/chronic bronchitis	1.2	1.3	2.1	-1.5	-0.7	1.2
Medication for pain relief, constipation, heartburn	4.5	7.6	11.4	2.3	2.5	-3.4
Neck or shoulder pain in last month	2.0	2.8	3.5	-1.7	-1.4	1.9
Medication: Blood pressure	0.2	0.3	0.5	-0.4	-0.7	0.5
Angina (self-reported)	0.6	0.7	1.8	-0.4	1.4	-0.4
Migraine (self-reported)	0.1	0.2	0.3	-0.1	-0.6	0.4
Medication: Ibuprofen	2.7	3.2	4.6	-1.5	-1.6	2.1
Medication: Allopurinol	1.5	2.0	5.6	-0.4	-2.4	0.6
Medication: Omeprazole	1.3	1.5	2.4	-1.6	-0.8	1.2
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.4	1.0	-0.1
Mean time to correctly identify matches	0.5	1.0	1.7	-1.3	-0.5	1.0
Heart disease (mother)	0.4	0.5	0.9	-0.1	1.0	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.1	-0.1	-0.8
Whole body fat mass	1.4	5.9	9.4	-3.1	-1.7	2.3
Leg fat mass (right)	1.6	6.2	10.4	-3.2	-1.6	2.4
Arm predicted mass (right)	2.1	10.5	18.1	-4.3	-1.5	3.4
Pulse rate, automated reading	0.2	0.7	1.6	0.6	1.3	-0.1
Alcohol intake frequency.	1.7	4.1	6.5	-1.7	-1.7	2.6
Comparative height size at age 10	0.5	2.9	5.6	-2.4	-0.9	1.5
Number of full sisters	0.1	0.1	0.2	0.1	0.4	-0.4
Suffer from ‘nerves’	0.3	0.4	0.5	0.6	0.7	-0.7
Overall health rating	0.2	0.4	1.0	-1.0	-0.0	0.5
Chest pain or discomfort	0.0	0.1	0.2	-0.4	0.0	0.0
Had major operations	0.4	0.5	0.7	-0.3	0.8	0.7
Age at last live birth	2.0	2.9	3.9	-1.8	-2.0	1.3
Family relationship satisfaction	0.7	0.8	1.3	-1.1	-0.0	1.1
Leg pain on walking	0.0	0.1	0.1	0.2	0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	0.8	1.1	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.2	0.4	0.3	0.6	-0.0
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.4	1.2	-0.0	-1.2
Medication: Aspirin	2.6	3.4	5.3	-2.3	-1.2	1.9
Supplements: Vitamin C	0.6	0.7	0.8	0.9	-0.9	-0.7
Knee pain experienced in last month	1.0	1.6	3.2	-0.7	1.8	1.0
Hypertension (Self-reported)	0.4	1.2	1.3	-1.1	-1.1	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.8	5.8	-2.4	-0.7	2.3
Illnesses of father: Heart disease	0.4	0.6	1.0	-1.0	0.3	0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.5	0.7	0.4	-0.7
Smoking status: Previous	0.4	0.6	1.6	0.4	0.4	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	5.0	-1.9	-1.6	2.2
Whole body fat-free mass	1.8	10.0	17.3	-4.2	-1.1	3.4
Leg fat-free mass (right)	2.2	11.9	18.3	-4.3	-1.6	3.9
Arm fat percentage (left)	0.7	2.9	4.1	-2.0	-1.5	1.5
Average weekly red wine intake	0.6	1.0	1.4	0.3	-1.2	-1.2
Handedness (chirality/laterality): Left-handed	1.4	1.7	4.1	-0.6	-2.0	0.8
Mood swings	1.5	2.7	3.8	1.3	1.9	-1.6
Loneliness, isolation	0.1	0.1	0.3	0.0	0.1	0.5
Long-standing illness, disability or infirmity	0.2	0.2	0.5	-0.4	-0.7	0.2
Ever had bowel cancer screening	0.6	0.7	1.3	1.2	-0.4	-0.7
Diabetes diagnosed by doctor	0.5	0.8	2.1	-0.4	-1.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	0.1	0.6	0.7
Friendships satisfaction	1.0	1.2	3.5	-0.1	1.9	-0.2
Qualifications: nursing, teaching	0.6	0.9	2.1	0.7	-1.4	-0.3
Commuting to job workplace: Walk	2.8	3.0	3.2	-1.8	-1.7	1.8
Eye problems/disorders: Cataract	0.5	0.6	1.3	-0.1	0.7	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.4	-0.6	-0.1	0.5
Medication for cholesterol	0.0	0.1	0.1	-0.0	-0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	0.8	-0.9	-0.9	0.6
Back pain experienced in last month	1.2	1.8	2.7	-1.6	-0.8	1.4
Mineral and other dietary supplements	0.1	0.1	0.1	-0.4	-0.4	0.4
Breast cancer (self-reported)	0.3	0.3	0.4	0.6	-0.3	-0.7
Asthma (self-reported)	0.1	0.1	0.2	-0.2	-0.2	0.5
Osteoporosis (self-reported)	1.5	1.9	5.5	0.1	2.3	0.3
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.4	0.6	0.1
Medication: Aspirin	2.8	3.6	6.2	-2.5	-1.0	1.9
Medication: Gliclazide	0.3	0.4	0.7	-0.4	0.8	-0.4
Illnesses of father: None of the above (group 1)	2.2	2.7	3.2	1.7	1.5	-1.8
Smoking status: Current	0.6	1.0	1.8	-1.3	-0.5	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.5	0.6	-0.7	-0.6
Whole body water mass	1.7	10.0	17.1	-4.1	-1.1	3.4
Leg predicted mass (right)	2.2	11.7	18.2	-4.3	-1.5	3.8
Arm fat mass (left)	1.3	5.4	8.7	-3.0	-1.5	2.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.0	0.9	0.7	-1.0
Average weekly champagne plus white wine intake	0.1	0.2	0.5	-0.1	-0.7	-0.1
Miserableness	0.3	0.6	1.1	-1.0	0.7	0.5
Guilty feelings	0.5	0.8	2.2	0.4	0.2	-1.5
Wears glasses or contact lenses	3.0	3.5	4.5	1.3	2.1	-2.0
Ever taken oral contraceptive pill	1.8	2.0	2.9	1.7	0.5	-1.7
Hearing aid user	1.7	1.9	4.6	2.2	0.5	-0.9
Mother’s age at death	0.8	1.0	3.0	0.0	1.7	-0.1
Financial situation satisfaction	2.3	2.8	3.9	-2.0	1.2	1.7
Tinnitus: Yes, now most or all of the time	3.5	4.1	5.1	2.2	1.6	-2.3
Commuting to job workplace: Public transport	0.5	0.6	1.0	1.0	0.8	-0.4
Eye problems/disorders: Glaucoma	0.5	0.6	1.8	0.3	1.3	0.2
Medication: Blood pressure	0.1	0.1	0.2	-0.3	0.5	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	0.2	0.9	-0.2
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.1	0.7	-0.3
High cholesterol (Self-reported)	1.5	2.7	5.2	1.5	0.8	-2.3
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.2	0.2	-0.0
Medication: Paracetamol	0.8	1.2	3.0	0.3	-1.7	0.8
Medication: Lisinopril	2.3	3.0	4.8	-2.2	-0.2	2.0
Medication: Atorvastatin	0.2	0.2	0.3	-0.6	-0.2	0.5
Illnesses of father: High blood pressure	1.0	1.3	1.5	-1.0	-1.2	1.2
Alcohol drinker status: Never	1.5	1.7	2.1	-1.3	-1.4	1.2
Ever smoked	0.3	0.5	0.9	0.2	0.9	-0.8
Basal metabolic rate	1.9	10.4	17.6	-4.2	-1.3	3.5
Leg fat percentage (left)	0.6	2.2	4.5	-2.1	-1.0	1.0
Arm fat-free mass (left)	1.6	8.1	15.1	-3.9	-0.5	3.0
Number of operations (self-reported)	0.1	0.2	0.3	0.5	-0.4	-0.3
Average weekly beer plus cider intake	1.0	1.5	3.3	-1.0	-0.1	1.8
Irritability	0.1	0.2	0.3	-0.5	-0.5	0.2
Risk taking	0.1	0.2	0.5	0.2	-0.7	-0.2
Ever had prostate specific antigen (PSA) test	0.7	0.9	1.2	0.9	-0.7	-1.1
Fractured/broken bones in last 5 years	0.3	0.3	1.0	-0.1	1.0	0.0
Age started oral contraceptive pill	0.4	0.5	0.8	0.9	0.7	-0.5
Diastolic blood pressure, automated reading	1.6	4.8	8.0	-2.0	-1.5	2.8
Ever depressed for a whole week	1.3	1.6	3.1	-1.3	-0.2	1.8
Unable to work because of sickness or disability	0.3	0.4	0.9	0.4	-0.9	-0.4
Commuting to job workplace: Cycle	2.9	3.5	6.5	1.9	-0.2	-2.5
Myopia	0.1	0.2	0.3	-0.5	-0.1	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.2	1.1	0.5	-0.7
Cholesterol lowering medication	1.5	2.3	4.8	1.1	0.8	-2.2
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.7	-1.6	-0.7	1.4
Pain experienced in last month	0.4	0.6	0.8	0.8	0.9	-0.6
Supplements: Calcium	2.3	2.6	4.3	1.5	2.1	-1.0
Basal cell carcinoma (self-reported)	1.4	1.7	2.2	1.5	0.9	-1.5
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.2	-0.6	1.8	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.2	0.3	-1.5	-1.0
Heart disease (siblings)	2.8	3.5	5.1	-2.3	-0.9	2.1
Alcohol drinker status: Previous	0.9	1.0	2.8	0.5	1.7	0.3
Pack years of smoking	0.3	0.4	0.6	-0.1	0.7	0.8
Impedance of whole body	1.0	4.9	8.7	3.0	0.5	-2.4
Leg fat mass (left)	1.8	7.0	12.0	-3.5	-1.6	2.5
Arm predicted mass (left)	1.7	8.4	15.9	-4.0	-0.5	3.0