Hub : Genes

ME1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0550 0.0260 2.9e-03 0.009 0.006 -0.002 0.007 0.000 0.0270 4.9e-02 9.5e-01 4.5e-02 2.7e-01
2 GTEx Adrenal Gland 0.1221 0.0582 6.5e-03 0.024 NA -0.004 NA 0.038 0.0460 NA 4.9e-01 NA 1.7e-02
3 GTEx Artery Tibial 0.1401 0.0449 1.2e-05 0.049 NA 0.054 NA 0.065 0.0001 NA 4.7e-05 NA 7.8e-06
4 GTEx Cells Transformed fibroblasts 0.0590 0.0300 9.1e-03 0.006 NA 0.001 NA 0.001 0.1000 NA 2.4e-01 NA 2.5e-01
5 ROSMAP Brain Pre-frontal Cortex 0.0851 0.0303 5.3e-04 0.008 0.037 0.026 0.039 0.015 0.0270 1.2e-05 2.5e-04 8.8e-06 4.0e-03
6 TCGA Head and Neck Squamous Cell Carcinoma 0.0338 0.0199 3.3e-03 -0.002 0.009 0.001 NA -0.002 0.7700 2.9e-02 2.5e-01 NA 6.0e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 3.3 5.3 9.2 -2.4 -3.0 1.4 2.7 -0.7 -2.6
Bipolar Disorder or Schizophrenia 5.8 14.1 29.4 -3.3 -5.4 3.6 5.1 0.6 -2.2
Depressed Affect (Nagel 2018) 5.1 10.7 16.7 2.8 4.1 -3.6 -4.0 -1.0 3.2
Depression (Nagel 2018) 2.7 4.0 8.4 1.8 2.2 -1.1 -2.6 -0.0 2.9
Intelligence (Savage-Jansen 2018) 0.5 1.4 6.4 2.5 0.5 -0.9 -0.9 -0.3 0.1
Neuroticism (Nagel 2018) 4.5 10.6 15.4 2.8 3.9 -3.6 -3.9 0.3 3.5
Schizophrenia (2018) 4.9 10.1 20.2 -2.3 -4.5 3.6 4.5 1.3 -0.7
Schizophrenia vs Biploar Disorder 0.4 0.5 2.1 0.3 0.8 1.4 -0.4 -0.3 0.4
Worry (Nagel 2018) 2.2 4.6 8.9 2.0 2.2 -1.9 -3.0 1.4 2.1
Alzheimer’s Disease (in mother) 1.1 1.2 3.5 -0.1 1.7 -0.8 -1.9 0.2 -0.5
Alzheimer’s Disease (in father) 0.8 0.9 1.6 0.5 1.2 0.9 -1.2 0.1 1.0
Alzheimer’s Disease (including proxy) 0.8 1.1 3.2 -0.2 1.8 0.4 -1.7 -0.6 -0.1
Crohns Disease (2017) 0.1 0.3 0.7 -0.6 0.5 -0.8 -0.4 -0.5 -0.1
Irritable Bowel Disease (IBD) 0.3 0.7 1.5 0.3 1.0 -1.0 -0.9 -1.2 0.2
Ulcerative Colitis (UC) 0.3 0.5 1.9 0.5 0.6 -0.5 -0.6 -1.4 0.1
Major Depression (MDD) 1.2 1.4 2.4 0.4 1.2 -1.5 -1.5 0.4 1.4
Reaction Time 1.1 2.0 5.9 -2.4 -1.9 0.5 0.8 0.6 -1.2
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.7 1.7 1.1 -0.7 -1.6 -0.4 0.1
Breast Cancer 0.4 1.0 3.1 1.1 -0.3 0.8 0.8 1.8 0.8
Ovarian Cancer 0.5 0.7 1.5 0.5 1.2 -1.0 -0.4 0.4 1.1
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.2 0.3 0.9 -0.3 0.7 -0.2 -0.9 -0.5 -0.2
Bipolar Disorder (2011) 4.4 4.2 11.2 -0.9 -3.4 1.2 3.3 0.6 -0.8
Body Mass Index (BMI) (2010) 0.2 0.2 0.7 0.4 -0.9 0.6 0.0 -0.2 -0.2
Coronary Artery Disease (CAD) 3.6 4.3 8.0 1.0 2.8 -2.6 -2.8 -1.4 -0.7
Crohns Disease (2012) 0.0 0.1 0.2 0.0 -0.1 -0.2 -0.1 0.2 -0.5
Mean Putamen Volume 1.0 1.1 2.9 0.9 0.9 -0.2 -1.7 1.3 0.6
Fasting Glucose 0.1 0.1 0.4 0.2 0.1 -0.5 -0.2 -0.6 0.2
HbA1C 0.7 0.7 2.6 1.1 0.1 0.7 -0.1 0.1 1.6
HDL Cholesterol 0.8 1.4 3.1 -0.4 1.8 -1.6 -1.5 -0.5 0.1
LDL Cholesterol 0.7 1.1 5.6 0.8 0.4 -0.2 0.5 -2.4 0.2
Lupus 0.7 1.1 5.2 -0.7 0.0 -0.1 -0.4 2.3 0.9
Neuroticism (2016) 0.3 0.4 1.7 -0.4 -0.2 -0.7 -0.1 1.3 0.4
Primary Biliary Cirrhosis 0.6 0.9 3.0 0.9 0.0 -0.8 -0.3 -1.0 -1.7
Rheumatoid Arthritis 0.1 0.2 0.6 -0.3 0.0 0.7 0.3 0.5 -0.3
Schizophrenia (2014) 3.8 8.4 15.1 -2.7 -3.9 3.8 3.4 1.0 -1.2
Triglycerides 0.1 0.2 0.4 0.4 -0.6 0.5 0.5 0.6 0.2
Type 2 Diabetes (T2D) (2012) 1.0 1.2 2.9 -1.7 -0.1 -0.8 -0.3 -1.4 -1.2
Ulcerative Colitis 0.9 1.2 1.7 1.2 1.2 -1.1 -1.3 -1.3 -0.2
Blood Eosinophil Count 0.1 0.5 1.5 0.6 1.0 -1.2 -0.3 0.4 -0.0
Blood Platelet Count 0.4 5.2 11.4 2.2 3.4 -1.5 -2.5 -1.6 1.9
Blood Red Count 0.1 1.1 2.7 0.2 -1.5 0.6 1.0 1.6 0.2
Blood White Count 0.2 1.2 3.0 1.7 0.1 -0.7 0.8 -1.6 0.6
Heel T-Score 1.1 8.6 23.9 0.1 2.0 -1.9 -1.2 4.3 4.9
BMI 0.6 3.3 7.4 2.0 2.4 -2.7 -1.1 -1.1 0.7
Height 0.3 5.6 15.4 3.3 0.9 0.3 -0.6 -2.5 3.9
Waist Hip Ratio (WHR) 0.7 3.1 8.9 2.0 2.1 -0.8 -0.2 0.4 3.0
Systolic Blood Pressure 0.6 2.8 7.7 -1.8 -1.5 1.3 1.3 0.5 -2.8
Smoking Status 2.8 6.7 13.6 3.7 2.8 -3.0 -1.9 -2.3 0.9
Allergy or Eczema 0.4 1.2 3.6 0.5 -1.0 0.4 0.7 1.9 1.2
Cardiovascular Disease 0.2 0.6 1.2 1.1 1.0 -0.6 -1.0 -0.2 -0.2
Hypothyroidism (self reported) 0.3 0.6 1.5 0.6 -0.4 0.9 0.7 0.5 -1.2
Respiratory disease 0.3 0.8 2.2 -1.5 0.4 0.8 -1.1 -0.6 0.4
Type 2 Diabetes (T2D) (2018) 0.6 1.2 2.2 1.5 1.3 -1.0 -1.0 -0.3 1.0
Lung FEV1/FVC ratio 0.9 4.4 10.0 2.4 2.6 -3.2 -1.9 -0.1 0.5
Lung FVC 0.7 3.7 7.3 2.1 1.8 -2.7 -1.1 -1.8 1.7
Neuroticism 3.0 7.1 12.7 2.5 3.4 -2.8 -3.6 -0.4 2.0
Chronotype (morning person) 0.9 2.1 8.6 -2.9 -1.5 0.0 0.6 0.1 -1.2
Hair Pigment 0.1 1.5 2.5 -0.9 -1.2 1.2 1.5 -0.7 -1.6
Tanning 0.1 0.9 2.1 0.2 1.0 -0.6 -1.4 -1.3 0.6
Hand grip strength (left) 1.8 4.6 9.6 2.5 2.2 -2.1 -1.2 -0.9 3.1
Number of treatments/medications taken 0.4 0.6 1.5 -0.1 1.2 -0.3 -1.1 -1.0 0.4
Average weekly spirits intake 0.4 0.4 1.0 0.4 1.0 -0.2 -0.9 -0.8 0.1
Sensitivity / hurt feelings 1.1 1.8 4.2 2.1 1.6 -1.3 -1.4 -0.4 -0.6
Frequency of depressed mood in last 2 weeks 5.5 7.7 13.0 2.7 3.0 -2.5 -3.6 -0.5 3.2
Hearing difficulty/problems: Yes 2.7 4.1 7.2 2.2 2.2 -2.7 -2.4 1.2 -0.3
Relative age of first facial hair 0.5 1.0 2.0 0.9 1.4 -1.3 -0.8 -0.2 0.8
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 4.1 2.0 1.2 -0.7 -1.8 0.7 1.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 3.1 1.2 0.7 -0.8 -0.4 1.8 1.6
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 -0.1 -0.2 -0.7 0.2 0.5 0.1
Systolic blood pressure, automated reading 0.3 0.8 2.3 -1.2 0.1 -0.8 0.5 -0.3 -1.5
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.8 0.5 0.9 -0.4 -0.6 0.8 0.1
Angina 0.6 0.8 1.7 1.1 1.2 -0.1 -0.6 -1.3 -0.0
Medication for hormone replacement therapy 1.0 1.1 3.1 -0.6 -1.8 1.3 0.9 0.2 -0.7
Vitamin and mineral supplements 1.0 1.3 3.1 -1.0 -1.1 -0.1 1.2 -1.1 -1.8
Supplements: Zinc 0.2 0.2 0.6 0.6 0.0 0.4 -0.0 0.8 0.4
Medication: Co-codamol 0.5 0.6 1.2 -0.7 -0.7 0.4 0.3 -1.0 -1.1
Medication: Metformin 0.9 1.3 3.0 1.2 1.0 -0.6 -1.0 0.9 1.7
Diabetes (father) 1.6 1.9 6.5 -0.3 -1.8 0.3 2.5 1.3 0.1
Diabetes (mother) 0.2 0.3 1.1 -0.2 0.5 1.0 0.2 -0.5 -0.1
Severe depression (siblings) 1.6 1.8 4.6 0.7 1.2 -0.4 -2.1 1.8 0.9
Pack years adult smoking proportion 1.1 1.7 4.8 -1.0 -1.3 1.3 0.6 2.2 0.9
Impedance of leg (right) 0.4 1.9 3.7 -1.9 -1.2 1.8 1.0 1.0 -1.0
Leg fat-free mass (left) 0.9 4.9 9.1 3.0 2.2 -1.7 -1.5 -2.1 2.4
Trunk fat percentage 0.6 2.4 5.2 0.6 1.9 -1.4 -1.1 -2.3 -1.4
Hand grip strength (right) 1.7 4.5 5.8 2.2 2.4 -2.3 -1.7 -1.7 2.3
Townsend deprivation index at recruitment 0.9 1.3 3.0 0.8 1.2 -1.7 -0.5 -1.6 -0.4
Current tobacco smoking 2.2 3.6 6.2 2.2 2.0 -2.5 -2.1 -1.0 1.2
Average weekly fortified wine intake 1.5 1.8 4.1 -0.9 -1.6 1.0 0.6 2.0 -1.3
Maternal smoking around birth 2.9 4.2 9.4 0.8 2.5 -2.1 -3.1 -2.0 -0.8
Fed-up feelings 5.5 10.0 14.9 3.8 3.9 -2.8 -3.8 -0.4 2.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 4.0 0.7 1.7 -0.5 -2.0 -0.7 0.7
Relative age voice broke 0.2 0.3 1.1 0.4 0.5 -0.3 -1.1 -0.4 0.5
Taking other prescription medications 0.6 1.0 2.9 -1.7 0.4 0.3 -0.9 -0.3 -1.3
Age when periods started (menarche) 0.4 1.0 2.7 -0.0 0.6 1.5 -0.8 0.2 1.6
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 -0.3 -0.4 -0.6 0.3 -0.2 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 5.3 0.1 1.0 -1.5 -0.7 -0.2 2.3
Tinnitus: Yes, but not now, but have in the past 0.9 0.9 2.5 1.6 0.5 -0.9 0.1 -1.1 0.9
Qualifications: CSEs or equivalent 0.9 1.2 3.6 0.6 -1.1 1.2 1.9 -0.5 0.4
Serious illness, injury or assault to yourself 0.8 1.0 1.8 -0.7 -1.2 0.9 1.1 0.3 -1.3
High blood pressure 0.6 1.8 2.7 1.6 1.6 -1.4 -1.4 -1.1 -0.6
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.6 0.1 -0.2 0.2 -0.1 0.8 0.8
Multivitamins +/- minerals 1.2 1.6 3.2 1.2 1.1 -0.7 -1.0 1.4 1.8
Stomach or abdominal pain in last month 0.4 0.5 1.9 0.1 0.4 -0.7 -0.6 -1.4 -0.2
Supplements: Glucosamine 1.0 1.2 3.9 0.6 0.6 0.6 -0.5 2.0 1.5
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.8 -0.4 -0.5 -0.9 0.9 0.3 -0.2
Medication: Atenolol 0.3 0.4 0.9 -0.5 -0.8 -0.6 0.9 0.7 0.2
Medication: Levothyroxine sodium 0.3 0.4 1.4 1.2 -0.1 0.4 -0.1 0.5 -0.9
Sitting height 0.6 4.0 8.2 2.1 1.8 -1.4 -1.6 -1.9 2.9
Chronic bronchitis/emphysema (father) 3.6 4.2 6.0 2.0 2.5 -2.1 -2.0 -2.2 1.4
High blood pressure (mother) 2.0 2.8 7.3 -0.5 -2.7 1.3 2.1 1.3 -1.2
Body mass index (BMI) 0.9 3.8 6.4 1.6 2.5 -2.5 -1.4 -2.3 -0.7
Impedance of leg (left) 0.3 1.2 2.1 -1.5 -0.9 1.4 0.8 1.0 -0.8
Leg predicted mass (left) 0.9 4.9 9.1 3.0 2.2 -1.8 -1.4 -2.1 2.4
Trunk fat mass 1.0 4.1 6.9 1.8 2.6 -2.3 -1.6 -2.6 -0.0
Waist circumference 1.0 3.8 7.4 2.1 2.7 -2.3 -0.9 -2.0 0.8
Number of incorrect matches in round 0.8 1.3 2.7 -0.1 1.0 -1.6 -1.1 1.2 1.2
Past tobacco smoking 0.9 1.7 4.0 -2.0 -1.4 1.7 0.8 0.6 -0.3
Alcohol usually taken with meals 1.6 2.7 3.3 1.7 1.7 -1.7 -1.6 -1.8 1.2
Nervous feelings 0.7 1.3 6.2 -0.2 -0.2 0.9 -0.4 2.5 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.3 0.5 0.4 -0.3 -0.8 -0.1 1.1
Hearing difficulty/problems with background noise 4.0 6.5 12.2 2.4 3.0 -3.5 -3.4 0.4 0.6
Hair/balding pattern: Pattern 2 0.2 0.3 0.5 0.7 0.5 -0.2 -0.6 -0.1 -0.6
Had menopause 0.3 0.4 1.5 0.5 0.2 -0.3 -0.1 1.2 0.6
Had other major operations 1.2 1.5 3.4 -1.4 -1.8 0.8 1.1 1.1 -0.6
Forced vital capacity (FVC) 0.6 2.4 7.9 1.6 0.4 -0.2 -0.1 -2.8 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 4.3 -0.6 0.3 -1.4 0.0 0.4 2.1
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 7.3 1.0 1.2 -1.6 -1.1 0.5 2.7
Qualifications: None of the above 1.2 2.6 7.0 -2.5 -0.8 0.4 0.3 -1.2 -2.6
Financial difficulties in last 2 years 1.3 1.8 5.6 1.9 0.4 -0.1 -0.8 -2.4 0.9
Mouth/teeth dental problems 1.6 2.5 7.1 -0.1 -1.5 2.7 1.4 -1.1 -1.6
Heart attack 0.4 0.6 1.6 0.8 1.3 -0.6 -0.6 0.4 0.4
Allergy 0.2 0.4 2.1 1.5 0.1 -0.3 0.1 -0.3 -0.2
Pain all over the body in last month 1.2 1.3 2.8 -1.1 -1.2 0.5 1.7 -0.3 -1.4
Diabetes (self-reported) 0.7 1.1 1.5 1.2 1.1 -1.2 -1.0 0.6 0.8
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.0 1.0 0.1 -0.9 0.0 -0.0 0.6
Medication: Ramipril 0.2 0.2 0.6 0.5 0.2 0.7 -0.2 0.4 -0.7
Medication: Simvastatin 0.7 1.1 2.4 1.3 1.5 -0.5 -0.8 -1.0 0.7
Fluid intelligence score 1.7 3.5 6.9 2.6 2.0 -1.6 -2.5 -0.7 0.7
Illnesses of siblings 1.6 2.3 4.2 2.0 1.6 -1.3 -0.8 -1.0 1.9
Neuroticism score 2.2 4.5 8.9 2.4 2.8 -1.8 -3.0 -0.5 1.2
Weight 1.2 5.9 8.9 3.0 2.9 -2.6 -1.7 -2.6 1.5
Impedance of arm (right) 2.2 10.3 17.1 -3.4 -3.9 4.1 2.7 0.7 -3.2
Arm fat percentage (right) 0.4 1.7 4.5 0.3 0.9 -0.8 -0.1 -2.1 -2.1
Trunk fat-free mass 1.2 7.0 14.1 3.5 2.3 -2.5 -1.1 -1.6 3.8
Hip circumference 0.5 2.0 4.7 1.2 1.4 -1.7 -0.7 -2.2 -0.4
Time employed in main current job 0.3 0.3 0.8 0.4 -0.6 0.9 -0.1 0.6 0.5
Alcohol intake versus 10 years previously 0.7 1.0 3.6 1.2 0.4 -0.8 -0.5 0.4 1.9
Father’s age at death 0.4 0.6 1.1 -1.0 -0.7 0.7 0.8 0.9 -0.3
Worrier / anxious feelings 2.4 4.6 9.7 2.5 2.3 -1.5 -3.1 0.9 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.7 1.4 1.0 -0.7 -1.9 -1.4 -0.0
Falls in the last year 0.6 0.8 1.0 0.9 0.8 -1.0 -0.9 0.8 1.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 0.4 -0.8 -0.5 0.8 0.1 -0.3
Number of live births 0.9 1.3 2.8 -0.2 -1.6 1.2 1.7 0.8 -0.6
Forced expiratory volume in 1-second (FEV1) 1.1 3.6 6.9 2.4 1.4 -1.5 -0.8 -2.6 2.0
Pulse rate 0.6 1.0 2.1 1.4 -0.1 1.0 0.9 0.0 1.5
Happiness 2.2 2.6 8.5 0.2 1.9 -1.0 -2.9 -1.4 0.8
Noisy workplace 0.9 1.1 2.4 -0.2 -0.2 1.6 0.7 -1.5 -1.0
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.4 0.5 0.4 0.2 -0.5 -0.6 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 1.2 1.1 -0.6 1.0 -0.0 -0.2 0.8
Mouth/teeth dental problems: Dentures 0.3 0.5 1.4 0.5 0.6 -1.2 -0.4 0.7 0.5
Asthma 0.3 0.6 1.8 -1.4 -0.3 1.2 -0.3 -0.3 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.9 -0.4 0.3 0.0 0.4 0.0 1.0
Medication: Cholesterol lowering 0.4 0.6 2.0 0.0 0.4 1.1 0.2 -1.4 -0.2
Depression (self-reported) 2.8 3.4 5.8 2.4 1.5 0.3 -1.7 -1.8 2.4
Medication: Lansoprazole 0.6 0.7 1.6 -0.9 -0.7 -0.2 1.3 -0.8 -0.9
Prospective memory result 1.1 1.3 4.2 -0.2 -0.9 -0.0 1.6 2.0 0.4
Lung cancer (father) 0.9 1.0 2.4 1.4 0.8 -0.7 -1.6 0.3 0.7
Illnesses of mother 0.5 0.6 1.4 0.4 0.8 -1.2 -1.1 -0.5 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 3.9 1.9 1.0 -1.8 -0.4 -1.7 2.0
Pulse wave Arterial Stiffness index 1.4 1.7 3.8 2.0 1.0 -1.4 -1.5 0.3 0.9
Impedance of arm (left) 1.6 7.6 12.3 -3.1 -3.2 3.5 2.2 1.0 -2.6
Arm fat mass (right) 0.7 2.8 5.9 1.6 2.0 -1.8 -0.9 -2.4 -0.6
Trunk predicted mass 1.2 7.1 14.0 3.6 2.4 -2.5 -1.1 -1.6 3.7
Standing height 0.5 5.2 18.5 3.0 1.1 -0.5 -0.7 -1.2 4.3
Length of working week for main job 0.8 0.9 3.3 0.0 0.8 -1.2 -0.3 -0.2 1.8
Exposure to tobacco smoke at home 0.1 0.2 0.6 -0.7 -0.0 0.1 0.0 0.3 -0.5
Breastfed as a baby 0.9 1.1 3.8 -0.7 0.5 -1.3 -0.4 -0.5 -2.0
Tense / ‘highly strung’ 3.6 6.0 10.5 1.9 3.2 -2.7 -3.2 -0.4 2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.8 8.1 1.9 2.8 -1.5 -2.9 -0.5 1.0
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 0.3 -0.1 0.0 -0.1 0.4 0.3
Birth weight of first child 0.4 0.8 1.5 1.2 1.1 -0.8 -0.1 0.3 1.1
Peak expiratory flow (PEF) 1.7 3.9 6.7 1.6 2.2 -2.6 -1.6 -2.2 1.3
Pulse wave reflection index 1.9 2.4 4.4 0.2 1.5 -2.0 -1.9 -2.1 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.5 0.4 1.1 -1.1 -1.2 -0.7 0.6
Loud music exposure frequency 2.9 3.1 6.6 2.6 1.1 -1.9 -0.2 -1.2 2.5
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 3.6 1.3 -1.2 1.0 1.9 0.8 1.3
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 3.5 -0.6 1.6 -1.3 -1.9 -1.2 0.4
Blood clot in the leg (DVT) 0.2 0.3 0.8 -0.0 0.3 -0.7 -0.0 -0.9 0.4
Medication: Paracetamol 0.5 0.8 2.1 -1.0 0.5 -0.1 -0.6 -0.9 -1.5
Headache pain in last month 2.0 3.4 7.0 2.6 1.7 -0.6 -2.3 -2.1 0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.6 0.5 -0.6 -0.8 0.4 0.7 0.5
Glaucoma (self-reported) 1.7 1.9 6.3 -1.6 -0.7 1.5 -0.1 -0.4 -2.5
Gout (self-reported) 0.2 0.3 0.6 -0.7 -0.1 -0.5 0.5 -0.7 -0.2
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.5 0.9 -0.9 1.1 1.2 1.0 -1.0
Medication: Amlodipine 0.4 0.6 1.3 0.3 0.0 -1.1 -0.1 -1.0 -1.2
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.6 -0.7 0.6 0.8 -0.8 -0.2 0.6
Birth weight 0.9 1.9 6.0 2.5 0.4 -1.0 0.7 0.2 2.0
Chronic bronchitis/emphysema (mother) 1.3 1.6 4.2 -2.1 -0.6 0.7 -0.1 2.0 -0.2
High blood pressure (siblings) 1.9 2.7 5.7 -2.0 -1.5 1.4 0.6 1.4 -2.4
Forced vital capacity (FVC), Best measure 0.5 1.9 4.8 1.2 0.4 -0.9 -0.0 -2.1 2.2
Body fat percentage 0.8 3.0 5.7 1.2 2.2 -1.7 -1.3 -2.4 -1.3
Leg fat percentage (right) 1.3 4.8 8.5 1.9 2.9 -2.6 -2.0 -2.3 -0.5
Arm fat-free mass (right) 2.5 12.6 20.3 4.5 3.9 -3.6 -2.4 -1.7 4.3
Exposure to tobacco smoke outside home 0.2 0.3 0.8 0.2 -0.4 -0.3 0.6 0.9 0.6
Comparative body size at age 10 0.3 0.7 2.6 -0.3 -0.3 -1.1 0.7 -0.3 -1.6
Number of full brothers 0.2 0.3 1.1 -0.2 0.2 -0.2 -1.1 -0.4 -0.4
Worry too long after embarrassment 0.4 0.6 1.4 0.2 1.1 -0.5 -1.2 -0.3 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 7.9 0.8 2.1 -1.2 -2.8 -0.0 0.6
Wheeze or whistling in the chest in last year 0.5 0.9 2.1 1.1 0.5 -0.0 -1.4 -1.4 -0.2
Number of children fathered 0.7 0.8 2.7 -1.6 0.1 1.0 -0.8 -0.1 0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 -0.4 0.6 -0.2 -0.5 0.8 0.1
Age at first live birth 0.5 1.0 3.2 1.0 0.9 -0.8 -0.3 -1.8 0.3
Pulse wave peak to peak time 1.2 1.4 3.1 -1.8 -0.9 1.4 1.4 -0.5 -0.7
Health satisfaction 0.2 0.3 1.3 0.3 -0.4 -0.2 -0.2 1.1 0.4
Shortness of breath walking on level ground 0.9 1.1 5.0 0.0 -0.6 0.9 0.1 2.2 -0.6
Qualifications: College or University degree 0.8 2.5 5.5 -0.1 2.1 -1.3 -2.4 -1.6 -0.8
Eye problems/disorders: None of the above 0.2 0.2 0.6 -0.1 -0.7 0.3 0.5 -0.2 0.4
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 -0.4 0.8 -0.5 -0.3 0.0 0.1
Emphysema/chronic bronchitis 0.2 0.2 0.5 0.0 0.6 -0.2 -0.7 -0.4 -0.4
Medication for pain relief, constipation, heartburn 0.2 0.4 1.0 1.0 -0.6 0.9 0.1 -0.5 0.3
Neck or shoulder pain in last month 0.5 0.8 3.6 0.1 -0.3 0.3 -0.7 0.5 1.9
Medication: Blood pressure 0.2 0.3 0.6 -0.7 0.8 0.0 -0.4 -0.5 -0.7
Angina (self-reported) 0.7 0.9 2.8 1.2 1.1 0.2 -0.4 -1.7 0.2
Migraine (self-reported) 0.3 0.4 1.3 -0.4 -0.4 0.2 0.7 1.1 -0.4
Medication: Ibuprofen 0.2 0.2 0.6 -0.4 -0.1 0.1 0.1 -0.7 0.7
Medication: Allopurinol 0.2 0.2 0.5 -0.7 -0.1 -0.3 0.5 -0.7 -0.2
Medication: Omeprazole 0.6 0.7 2.6 0.2 0.8 0.3 -1.6 -0.9 0.5
Medication: Seretide 50 evohaler 1.5 1.7 4.1 2.0 1.1 -1.9 -0.3 -0.6 0.9
Mean time to correctly identify matches 2.0 3.8 8.5 -2.9 -2.5 1.1 1.8 0.4 -1.8
Heart disease (mother) 0.1 0.1 0.1 -0.3 -0.3 0.0 0.3 0.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.4 -0.6 1.8 -1.3 -1.8 -0.3 -1.5
Whole body fat mass 1.2 5.0 8.6 2.0 2.9 -2.4 -1.6 -2.9 -0.1
Leg fat mass (right) 1.3 5.1 8.6 2.3 2.9 -2.6 -1.8 -2.5 0.4
Arm predicted mass (right) 2.7 13.9 20.7 4.5 4.1 -3.8 -2.5 -2.1 4.5
Pulse rate, automated reading 0.3 1.1 2.5 1.4 1.6 0.6 -0.8 -0.7 0.9
Alcohol intake frequency. 0.6 1.5 3.3 -1.1 -1.2 1.7 0.2 1.8 -0.1
Comparative height size at age 10 0.2 1.2 5.6 1.2 -0.2 -0.5 0.2 0.2 2.4
Number of full sisters 1.0 1.2 3.7 -1.9 -0.8 -0.1 -0.2 1.5 -0.8
Suffer from ‘nerves’ 0.3 0.4 1.1 0.8 0.2 0.3 -0.7 1.0 -0.4
Overall health rating 0.4 0.8 2.1 1.2 0.9 -0.1 -1.4 0.3 0.6
Chest pain or discomfort 0.4 0.6 2.3 1.0 -0.1 -0.1 -0.3 1.5 0.6
Had major operations 1.8 2.1 5.2 -2.3 -0.8 1.4 0.5 -0.8 -2.0
Age at last live birth 1.0 1.4 2.2 1.5 1.4 -1.1 -1.1 -1.0 1.0
Family relationship satisfaction 0.5 0.7 1.5 0.2 0.4 -0.6 -1.2 0.7 1.2
Leg pain on walking 0.4 0.5 1.9 -0.6 -0.2 -0.3 0.7 0.5 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.3 0.7 0.8 -1.1 -0.5 0.5 1.5
Commuting to job workplace: Car/motor vehicle 1.1 1.3 3.8 2.0 1.2 -0.5 -1.1 -0.2 0.8
Illness, injury, bereavement, stress in last 2 years 2.0 2.5 7.7 -0.8 0.8 -2.0 -0.8 2.8 1.0
Medication: Aspirin 0.4 0.6 1.4 -0.2 0.6 -1.0 0.5 1.2 0.7
Supplements: Vitamin C 0.3 0.3 0.8 0.6 0.4 0.9 -0.6 0.1 0.3
Knee pain experienced in last month 1.2 1.8 4.7 0.1 1.9 -2.2 -0.7 -0.5 1.3
Hypertension (Self-reported) 0.5 1.5 3.1 1.8 1.3 -1.6 -1.2 -0.5 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.1 2.5 0.1 1.4 -0.1 -1.6 -1.3 -0.6
Illnesses of father: Heart disease 1.4 1.9 4.6 -2.0 -1.3 0.5 0.7 -0.4 -2.1
Illnesses of siblings: Diabetes 0.3 0.3 0.9 -0.5 -0.5 0.9 0.5 -0.4 0.4
Smoking status: Previous 0.2 0.3 0.6 0.6 0.6 -0.8 0.0 -0.4 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 6.6 0.2 -1.3 2.6 1.5 -0.0 2.2
Whole body fat-free mass 1.2 7.0 13.0 3.6 2.5 -2.4 -1.3 -1.8 3.5
Leg fat-free mass (right) 1.0 5.1 10.1 3.2 2.2 -1.8 -1.5 -1.9 2.6
Arm fat percentage (left) 0.5 2.0 4.5 0.6 1.4 -1.2 -0.7 -2.1 -1.8
Average weekly red wine intake 2.0 3.0 7.1 1.3 1.7 -2.7 -2.0 -1.4 -0.3
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.6 0.6 0.2 -0.6 0.8 0.3 0.7
Mood swings 3.7 6.7 12.4 1.8 3.4 -3.5 -2.9 -0.7 2.1
Loneliness, isolation 0.9 1.3 3.3 0.7 1.1 0.1 -1.6 -1.8 -0.2
Long-standing illness, disability or infirmity 0.1 0.2 0.5 -0.5 -0.5 0.7 -0.4 0.1 -0.4
Ever had bowel cancer screening 0.3 0.3 0.6 -0.1 0.6 -0.6 -0.8 -0.5 -0.6
Diabetes diagnosed by doctor 0.7 1.1 1.8 1.4 1.2 -1.2 -0.9 0.7 1.0
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.8 3.6 0.7 -1.3 0.6 1.9 1.8 1.2
Friendships satisfaction 3.7 4.6 10.2 1.6 2.5 -2.6 -3.2 -0.3 1.3
Qualifications: nursing, teaching 1.2 1.9 3.5 1.8 1.1 -1.6 -1.9 -0.5 0.9
Commuting to job workplace: Walk 0.2 0.2 1.0 -1.0 0.2 -0.2 -0.3 -0.4 0.1
Eye problems/disorders: Cataract 1.2 1.4 3.8 1.0 1.4 -1.9 -1.1 -0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.7 -0.7 0.8 -1.3 -1.1 0.1 -0.3
Medication for cholesterol 0.3 0.4 1.7 -1.3 0.3 0.3 0.0 -0.1 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.9 -1.0 -0.5 0.4 0.5 -0.7 -0.6
Back pain experienced in last month 0.4 0.6 1.3 0.5 0.2 -0.1 -0.9 -1.1 1.1
Mineral and other dietary supplements 1.3 1.8 5.9 0.4 -1.0 0.2 0.7 -2.4 -1.8
Breast cancer (self-reported) 0.5 0.6 2.7 0.0 0.4 0.2 -0.5 -0.7 -1.6
Asthma (self-reported) 0.3 0.6 2.2 -1.5 -0.2 1.1 -0.5 -0.3 0.1
Osteoporosis (self-reported) 0.9 1.1 2.6 -1.6 0.7 -1.5 -0.7 0.4 -0.4
Osteoarthritis (self-reported) 0.3 0.4 0.8 -0.9 0.8 -0.7 -0.7 -0.4 0.4
Medication: Aspirin 0.5 0.7 1.7 -0.1 0.9 -1.0 -0.3 1.3 0.5
Medication: Gliclazide 1.0 1.1 2.9 1.7 1.0 -1.0 -0.6 -1.1 0.5
Illnesses of father: None of the above (group 1) 0.1 0.2 0.6 0.1 -0.2 0.8 -0.1 0.7 -0.2
Smoking status: Current 2.3 3.7 5.7 2.4 1.9 -2.4 -1.9 -1.1 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.6 0.8 0.0 -0.7 0.0 0.1 -0.2
Whole body water mass 1.2 7.1 13.5 3.7 2.5 -2.3 -1.4 -1.9 3.4
Leg predicted mass (right) 0.9 5.0 10.4 3.2 2.2 -1.7 -1.5 -1.8 2.6
Arm fat mass (left) 0.9 3.7 6.5 1.8 2.5 -2.1 -1.3 -2.5 -0.1
Number of self-reported non-cancer illnesses 0.5 0.8 1.4 0.7 1.0 -1.2 -1.2 -0.7 -0.5
Average weekly champagne plus white wine intake 0.5 0.7 2.1 0.3 -0.7 1.5 0.8 -0.8 -0.6
Miserableness 4.1 7.2 12.2 2.4 3.5 -2.7 -3.1 -2.0 2.1
Guilty feelings 1.6 2.4 3.3 1.8 1.8 -1.7 -1.6 -1.3 0.9
Wears glasses or contact lenses 1.5 1.7 5.8 0.7 1.1 -2.4 -1.5 0.3 0.5
Ever taken oral contraceptive pill 0.7 0.8 1.5 1.1 1.2 0.2 -1.2 0.2 0.9
Hearing aid user 1.4 1.6 2.7 1.3 1.3 -1.6 -1.6 -1.0 0.4
Mother’s age at death 0.8 1.0 3.2 0.8 1.2 -0.2 -0.7 -0.4 1.8
Financial situation satisfaction 3.9 4.8 10.0 1.7 2.6 -1.3 -3.2 -0.9 2.6
Tinnitus: Yes, now most or all of the time 1.4 1.6 3.6 1.2 1.1 -1.0 -1.9 1.1 1.1
Commuting to job workplace: Public transport 0.7 0.9 2.6 -0.7 -1.6 1.1 0.9 0.3 0.2
Eye problems/disorders: Glaucoma 3.3 3.9 12.0 -2.2 -1.3 1.0 1.1 -1.7 -3.5
Medication: Blood pressure 0.6 1.1 3.0 1.7 0.4 -0.6 -0.8 -0.5 -1.6
Pain type(s) experienced in last month: Hip pain 0.9 1.2 3.7 1.1 0.5 -1.4 -0.0 0.3 1.9
Supplements: Fish oil (including cod liver oil) 1.6 2.1 5.2 -0.1 1.0 -0.9 -0.7 2.3 2.2
High cholesterol (Self-reported) 0.3 0.6 1.9 0.2 0.4 0.9 0.6 -1.4 -0.4
Medication: Bendroflumethiazide 0.4 0.6 1.4 1.1 0.8 -0.0 -1.2 0.4 0.4
Medication: Paracetamol 0.7 1.1 3.0 -0.8 0.6 -0.5 -0.7 -1.7 -1.4
Medication: Lisinopril 0.3 0.4 1.4 1.2 0.1 0.6 -0.6 0.1 0.3
Medication: Atorvastatin 0.2 0.2 0.8 0.3 -0.0 0.6 0.9 -0.2 -0.1
Illnesses of father: High blood pressure 0.5 0.6 2.4 -0.4 -0.8 -0.2 0.7 1.6 -0.2
Alcohol drinker status: Never 1.4 1.7 3.1 -1.2 -1.8 1.7 1.4 0.1 -0.7
Ever smoked 1.9 3.4 6.8 2.4 1.8 -2.6 -1.2 -0.8 1.6
Basal metabolic rate 1.2 6.6 12.4 3.5 2.5 -2.3 -1.4 -2.0 3.1
Leg fat percentage (left) 1.5 5.4 9.6 2.2 3.1 -2.9 -2.1 -2.2 -0.4
Arm fat-free mass (left) 1.8 8.9 15.4 3.9 3.2 -2.8 -1.8 -1.8 3.7
Number of operations (self-reported) 0.9 1.3 4.2 -2.1 -0.9 -0.3 0.8 0.2 -1.5
Average weekly beer plus cider intake 0.5 0.7 1.5 -1.0 -0.3 0.3 0.5 -1.2 -1.2
Irritability 2.2 3.8 8.0 0.9 1.8 -1.4 -2.3 1.7 2.8
Risk taking 0.5 0.8 1.2 0.3 0.9 -1.1 -0.6 -1.1 1.1
Ever had prostate specific antigen (PSA) test 1.7 2.0 5.7 -1.4 0.4 -0.6 -1.1 -1.6 -2.4
Fractured/broken bones in last 5 years 0.2 0.2 0.3 -0.2 -0.5 0.5 0.5 0.5 -0.4
Age started oral contraceptive pill 3.4 4.3 8.5 1.9 2.9 -2.2 -2.6 -1.0 1.0
Diastolic blood pressure, automated reading 0.7 2.2 6.6 -2.5 -0.3 0.4 0.1 -0.7 -2.6
Ever depressed for a whole week 0.5 0.6 1.9 -0.1 0.8 -0.5 -0.7 -0.0 1.4
Unable to work because of sickness or disability 0.2 0.3 0.7 0.1 -0.5 0.2 0.4 -0.8 -0.7
Commuting to job workplace: Cycle 0.7 0.8 2.2 -0.4 -0.8 0.4 1.3 -0.1 -1.5
Myopia 0.3 0.4 1.4 -0.6 -0.4 1.2 -0.2 0.0 -0.6
Vascular/heart problems diagnosed by doctor 0.6 1.7 3.3 -1.8 -1.8 1.2 1.3 0.8 0.3
Cholesterol lowering medication 1.4 2.0 3.8 1.8 2.0 -1.7 -1.1 -0.1 0.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.9 -0.0 0.2 0.8 -0.9 -0.9 -0.0
Pain experienced in last month 1.3 2.2 3.5 -1.3 -1.7 1.9 1.4 0.9 -1.4
Supplements: Calcium 1.6 1.8 5.0 -1.8 0.2 1.1 -0.9 2.2 -0.7
Basal cell carcinoma (self-reported) 1.8 2.1 5.5 1.1 1.4 -2.3 -1.2 -0.2 1.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.2 0.7 1.1 -0.5 -0.4 0.5 0.3
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 1.0 0.2 0.4 -0.8 -0.2 -1.0 0.3
Heart disease (siblings) 0.7 0.9 2.3 -1.2 -0.6 1.1 -0.1 -0.1 -1.5
Alcohol drinker status: Previous 0.4 0.4 1.0 0.7 -0.3 -0.5 -0.6 0.5 1.0
Pack years of smoking 1.3 2.0 4.8 -1.3 -1.4 1.5 0.9 2.2 0.7
Impedance of whole body 0.8 4.0 7.2 -2.5 -2.2 2.7 1.3 1.1 -1.8
Leg fat mass (left) 1.4 5.4 9.0 2.5 3.0 -2.7 -1.9 -2.5 0.3
Arm predicted mass (left) 1.6 8.0 14.4 3.8 3.1 -2.6 -1.6 -1.9 3.4