Hub : Genes

ME1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0550	0.0260	2.9e-03	0.009	0.006	-0.002	0.007	0.000	0.0270	4.9e-02	9.5e-01	4.5e-02	2.7e-01
2	GTEx	Adrenal Gland	0.1221	0.0582	6.5e-03	0.024	NA	-0.004	NA	0.038	0.0460	NA	4.9e-01	NA	1.7e-02
3	GTEx	Artery Tibial	0.1401	0.0449	1.2e-05	0.049	NA	0.054	NA	0.065	0.0001	NA	4.7e-05	NA	7.8e-06
4	GTEx	Cells Transformed fibroblasts	0.0590	0.0300	9.1e-03	0.006	NA	0.001	NA	0.001	0.1000	NA	2.4e-01	NA	2.5e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0851	0.0303	5.3e-04	0.008	0.037	0.026	0.039	0.015	0.0270	1.2e-05	2.5e-04	8.8e-06	4.0e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0338	0.0199	3.3e-03	-0.002	0.009	0.001	NA	-0.002	0.7700	2.9e-02	2.5e-01	NA	6.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	3.3	5.3	9.2	-2.4	-3.0	1.4	2.7	-0.7	-2.6
Bipolar Disorder or Schizophrenia	5.8	14.1	29.4	-3.3	-5.4	3.6	5.1	0.6	-2.2
Depressed Affect (Nagel 2018)	5.1	10.7	16.7	2.8	4.1	-3.6	-4.0	-1.0	3.2
Depression (Nagel 2018)	2.7	4.0	8.4	1.8	2.2	-1.1	-2.6	-0.0	2.9
Intelligence (Savage-Jansen 2018)	0.5	1.4	6.4	2.5	0.5	-0.9	-0.9	-0.3	0.1
Neuroticism (Nagel 2018)	4.5	10.6	15.4	2.8	3.9	-3.6	-3.9	0.3	3.5
Schizophrenia (2018)	4.9	10.1	20.2	-2.3	-4.5	3.6	4.5	1.3	-0.7
Schizophrenia vs Biploar Disorder	0.4	0.5	2.1	0.3	0.8	1.4	-0.4	-0.3	0.4
Worry (Nagel 2018)	2.2	4.6	8.9	2.0	2.2	-1.9	-3.0	1.4	2.1
Alzheimer’s Disease (in mother)	1.1	1.2	3.5	-0.1	1.7	-0.8	-1.9	0.2	-0.5
Alzheimer’s Disease (in father)	0.8	0.9	1.6	0.5	1.2	0.9	-1.2	0.1	1.0
Alzheimer’s Disease (including proxy)	0.8	1.1	3.2	-0.2	1.8	0.4	-1.7	-0.6	-0.1
Crohns Disease (2017)	0.1	0.3	0.7	-0.6	0.5	-0.8	-0.4	-0.5	-0.1
Irritable Bowel Disease (IBD)	0.3	0.7	1.5	0.3	1.0	-1.0	-0.9	-1.2	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.9	0.5	0.6	-0.5	-0.6	-1.4	0.1
Major Depression (MDD)	1.2	1.4	2.4	0.4	1.2	-1.5	-1.5	0.4	1.4
Reaction Time	1.1	2.0	5.9	-2.4	-1.9	0.5	0.8	0.6	-1.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	1.7	1.1	-0.7	-1.6	-0.4	0.1
Breast Cancer	0.4	1.0	3.1	1.1	-0.3	0.8	0.8	1.8	0.8
Ovarian Cancer	0.5	0.7	1.5	0.5	1.2	-1.0	-0.4	0.4	1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.2	0.3	0.9	-0.3	0.7	-0.2	-0.9	-0.5	-0.2
Bipolar Disorder (2011)	4.4	4.2	11.2	-0.9	-3.4	1.2	3.3	0.6	-0.8
Body Mass Index (BMI) (2010)	0.2	0.2	0.7	0.4	-0.9	0.6	0.0	-0.2	-0.2
Coronary Artery Disease (CAD)	3.6	4.3	8.0	1.0	2.8	-2.6	-2.8	-1.4	-0.7
Crohns Disease (2012)	0.0	0.1	0.2	0.0	-0.1	-0.2	-0.1	0.2	-0.5
Mean Putamen Volume	1.0	1.1	2.9	0.9	0.9	-0.2	-1.7	1.3	0.6
Fasting Glucose	0.1	0.1	0.4	0.2	0.1	-0.5	-0.2	-0.6	0.2
HbA1C	0.7	0.7	2.6	1.1	0.1	0.7	-0.1	0.1	1.6
HDL Cholesterol	0.8	1.4	3.1	-0.4	1.8	-1.6	-1.5	-0.5	0.1
LDL Cholesterol	0.7	1.1	5.6	0.8	0.4	-0.2	0.5	-2.4	0.2
Lupus	0.7	1.1	5.2	-0.7	0.0	-0.1	-0.4	2.3	0.9
Neuroticism (2016)	0.3	0.4	1.7	-0.4	-0.2	-0.7	-0.1	1.3	0.4
Primary Biliary Cirrhosis	0.6	0.9	3.0	0.9	0.0	-0.8	-0.3	-1.0	-1.7
Rheumatoid Arthritis	0.1	0.2	0.6	-0.3	0.0	0.7	0.3	0.5	-0.3
Schizophrenia (2014)	3.8	8.4	15.1	-2.7	-3.9	3.8	3.4	1.0	-1.2
Triglycerides	0.1	0.2	0.4	0.4	-0.6	0.5	0.5	0.6	0.2
Type 2 Diabetes (T2D) (2012)	1.0	1.2	2.9	-1.7	-0.1	-0.8	-0.3	-1.4	-1.2
Ulcerative Colitis	0.9	1.2	1.7	1.2	1.2	-1.1	-1.3	-1.3	-0.2
Blood Eosinophil Count	0.1	0.5	1.5	0.6	1.0	-1.2	-0.3	0.4	-0.0
Blood Platelet Count	0.4	5.2	11.4	2.2	3.4	-1.5	-2.5	-1.6	1.9
Blood Red Count	0.1	1.1	2.7	0.2	-1.5	0.6	1.0	1.6	0.2
Blood White Count	0.2	1.2	3.0	1.7	0.1	-0.7	0.8	-1.6	0.6
Heel T-Score	1.1	8.6	23.9	0.1	2.0	-1.9	-1.2	4.3	4.9
BMI	0.6	3.3	7.4	2.0	2.4	-2.7	-1.1	-1.1	0.7
Height	0.3	5.6	15.4	3.3	0.9	0.3	-0.6	-2.5	3.9
Waist Hip Ratio (WHR)	0.7	3.1	8.9	2.0	2.1	-0.8	-0.2	0.4	3.0
Systolic Blood Pressure	0.6	2.8	7.7	-1.8	-1.5	1.3	1.3	0.5	-2.8
Smoking Status	2.8	6.7	13.6	3.7	2.8	-3.0	-1.9	-2.3	0.9
Allergy or Eczema	0.4	1.2	3.6	0.5	-1.0	0.4	0.7	1.9	1.2
Cardiovascular Disease	0.2	0.6	1.2	1.1	1.0	-0.6	-1.0	-0.2	-0.2
Hypothyroidism (self reported)	0.3	0.6	1.5	0.6	-0.4	0.9	0.7	0.5	-1.2
Respiratory disease	0.3	0.8	2.2	-1.5	0.4	0.8	-1.1	-0.6	0.4
Type 2 Diabetes (T2D) (2018)	0.6	1.2	2.2	1.5	1.3	-1.0	-1.0	-0.3	1.0
Lung FEV1/FVC ratio	0.9	4.4	10.0	2.4	2.6	-3.2	-1.9	-0.1	0.5
Lung FVC	0.7	3.7	7.3	2.1	1.8	-2.7	-1.1	-1.8	1.7
Neuroticism	3.0	7.1	12.7	2.5	3.4	-2.8	-3.6	-0.4	2.0
Chronotype (morning person)	0.9	2.1	8.6	-2.9	-1.5	0.0	0.6	0.1	-1.2
Hair Pigment	0.1	1.5	2.5	-0.9	-1.2	1.2	1.5	-0.7	-1.6
Tanning	0.1	0.9	2.1	0.2	1.0	-0.6	-1.4	-1.3	0.6
Hand grip strength (left)	1.8	4.6	9.6	2.5	2.2	-2.1	-1.2	-0.9	3.1
Number of treatments/medications taken	0.4	0.6	1.5	-0.1	1.2	-0.3	-1.1	-1.0	0.4
Average weekly spirits intake	0.4	0.4	1.0	0.4	1.0	-0.2	-0.9	-0.8	0.1
Sensitivity / hurt feelings	1.1	1.8	4.2	2.1	1.6	-1.3	-1.4	-0.4	-0.6
Frequency of depressed mood in last 2 weeks	5.5	7.7	13.0	2.7	3.0	-2.5	-3.6	-0.5	3.2
Hearing difficulty/problems: Yes	2.7	4.1	7.2	2.2	2.2	-2.7	-2.4	1.2	-0.3
Relative age of first facial hair	0.5	1.0	2.0	0.9	1.4	-1.3	-0.8	-0.2	0.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	4.1	2.0	1.2	-0.7	-1.8	0.7	1.3
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.1	1.2	0.7	-0.8	-0.4	1.8	1.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.1	-0.2	-0.7	0.2	0.5	0.1
Systolic blood pressure, automated reading	0.3	0.8	2.3	-1.2	0.1	-0.8	0.5	-0.3	-1.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.5	0.9	-0.4	-0.6	0.8	0.1
Angina	0.6	0.8	1.7	1.1	1.2	-0.1	-0.6	-1.3	-0.0
Medication for hormone replacement therapy	1.0	1.1	3.1	-0.6	-1.8	1.3	0.9	0.2	-0.7
Vitamin and mineral supplements	1.0	1.3	3.1	-1.0	-1.1	-0.1	1.2	-1.1	-1.8
Supplements: Zinc	0.2	0.2	0.6	0.6	0.0	0.4	-0.0	0.8	0.4
Medication: Co-codamol	0.5	0.6	1.2	-0.7	-0.7	0.4	0.3	-1.0	-1.1
Medication: Metformin	0.9	1.3	3.0	1.2	1.0	-0.6	-1.0	0.9	1.7
Diabetes (father)	1.6	1.9	6.5	-0.3	-1.8	0.3	2.5	1.3	0.1
Diabetes (mother)	0.2	0.3	1.1	-0.2	0.5	1.0	0.2	-0.5	-0.1
Severe depression (siblings)	1.6	1.8	4.6	0.7	1.2	-0.4	-2.1	1.8	0.9
Pack years adult smoking proportion	1.1	1.7	4.8	-1.0	-1.3	1.3	0.6	2.2	0.9
Impedance of leg (right)	0.4	1.9	3.7	-1.9	-1.2	1.8	1.0	1.0	-1.0
Leg fat-free mass (left)	0.9	4.9	9.1	3.0	2.2	-1.7	-1.5	-2.1	2.4
Trunk fat percentage	0.6	2.4	5.2	0.6	1.9	-1.4	-1.1	-2.3	-1.4
Hand grip strength (right)	1.7	4.5	5.8	2.2	2.4	-2.3	-1.7	-1.7	2.3
Townsend deprivation index at recruitment	0.9	1.3	3.0	0.8	1.2	-1.7	-0.5	-1.6	-0.4
Current tobacco smoking	2.2	3.6	6.2	2.2	2.0	-2.5	-2.1	-1.0	1.2
Average weekly fortified wine intake	1.5	1.8	4.1	-0.9	-1.6	1.0	0.6	2.0	-1.3
Maternal smoking around birth	2.9	4.2	9.4	0.8	2.5	-2.1	-3.1	-2.0	-0.8
Fed-up feelings	5.5	10.0	14.9	3.8	3.9	-2.8	-3.8	-0.4	2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.0	0.7	1.7	-0.5	-2.0	-0.7	0.7
Relative age voice broke	0.2	0.3	1.1	0.4	0.5	-0.3	-1.1	-0.4	0.5
Taking other prescription medications	0.6	1.0	2.9	-1.7	0.4	0.3	-0.9	-0.3	-1.3
Age when periods started (menarche)	0.4	1.0	2.7	-0.0	0.6	1.5	-0.8	0.2	1.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	-0.3	-0.4	-0.6	0.3	-0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.3	0.1	1.0	-1.5	-0.7	-0.2	2.3
Tinnitus: Yes, but not now, but have in the past	0.9	0.9	2.5	1.6	0.5	-0.9	0.1	-1.1	0.9
Qualifications: CSEs or equivalent	0.9	1.2	3.6	0.6	-1.1	1.2	1.9	-0.5	0.4
Serious illness, injury or assault to yourself	0.8	1.0	1.8	-0.7	-1.2	0.9	1.1	0.3	-1.3
High blood pressure	0.6	1.8	2.7	1.6	1.6	-1.4	-1.4	-1.1	-0.6
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.6	0.1	-0.2	0.2	-0.1	0.8	0.8
Multivitamins +/- minerals	1.2	1.6	3.2	1.2	1.1	-0.7	-1.0	1.4	1.8
Stomach or abdominal pain in last month	0.4	0.5	1.9	0.1	0.4	-0.7	-0.6	-1.4	-0.2
Supplements: Glucosamine	1.0	1.2	3.9	0.6	0.6	0.6	-0.5	2.0	1.5
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.8	-0.4	-0.5	-0.9	0.9	0.3	-0.2
Medication: Atenolol	0.3	0.4	0.9	-0.5	-0.8	-0.6	0.9	0.7	0.2
Medication: Levothyroxine sodium	0.3	0.4	1.4	1.2	-0.1	0.4	-0.1	0.5	-0.9
Sitting height	0.6	4.0	8.2	2.1	1.8	-1.4	-1.6	-1.9	2.9
Chronic bronchitis/emphysema (father)	3.6	4.2	6.0	2.0	2.5	-2.1	-2.0	-2.2	1.4
High blood pressure (mother)	2.0	2.8	7.3	-0.5	-2.7	1.3	2.1	1.3	-1.2
Body mass index (BMI)	0.9	3.8	6.4	1.6	2.5	-2.5	-1.4	-2.3	-0.7
Impedance of leg (left)	0.3	1.2	2.1	-1.5	-0.9	1.4	0.8	1.0	-0.8
Leg predicted mass (left)	0.9	4.9	9.1	3.0	2.2	-1.8	-1.4	-2.1	2.4
Trunk fat mass	1.0	4.1	6.9	1.8	2.6	-2.3	-1.6	-2.6	-0.0
Waist circumference	1.0	3.8	7.4	2.1	2.7	-2.3	-0.9	-2.0	0.8
Number of incorrect matches in round	0.8	1.3	2.7	-0.1	1.0	-1.6	-1.1	1.2	1.2
Past tobacco smoking	0.9	1.7	4.0	-2.0	-1.4	1.7	0.8	0.6	-0.3
Alcohol usually taken with meals	1.6	2.7	3.3	1.7	1.7	-1.7	-1.6	-1.8	1.2
Nervous feelings	0.7	1.3	6.2	-0.2	-0.2	0.9	-0.4	2.5	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.3	0.5	0.4	-0.3	-0.8	-0.1	1.1
Hearing difficulty/problems with background noise	4.0	6.5	12.2	2.4	3.0	-3.5	-3.4	0.4	0.6
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	0.7	0.5	-0.2	-0.6	-0.1	-0.6
Had menopause	0.3	0.4	1.5	0.5	0.2	-0.3	-0.1	1.2	0.6
Had other major operations	1.2	1.5	3.4	-1.4	-1.8	0.8	1.1	1.1	-0.6
Forced vital capacity (FVC)	0.6	2.4	7.9	1.6	0.4	-0.2	-0.1	-2.8	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.3	-0.6	0.3	-1.4	0.0	0.4	2.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	7.3	1.0	1.2	-1.6	-1.1	0.5	2.7
Qualifications: None of the above	1.2	2.6	7.0	-2.5	-0.8	0.4	0.3	-1.2	-2.6
Financial difficulties in last 2 years	1.3	1.8	5.6	1.9	0.4	-0.1	-0.8	-2.4	0.9
Mouth/teeth dental problems	1.6	2.5	7.1	-0.1	-1.5	2.7	1.4	-1.1	-1.6
Heart attack	0.4	0.6	1.6	0.8	1.3	-0.6	-0.6	0.4	0.4
Allergy	0.2	0.4	2.1	1.5	0.1	-0.3	0.1	-0.3	-0.2
Pain all over the body in last month	1.2	1.3	2.8	-1.1	-1.2	0.5	1.7	-0.3	-1.4
Diabetes (self-reported)	0.7	1.1	1.5	1.2	1.1	-1.2	-1.0	0.6	0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.0	1.0	0.1	-0.9	0.0	-0.0	0.6
Medication: Ramipril	0.2	0.2	0.6	0.5	0.2	0.7	-0.2	0.4	-0.7
Medication: Simvastatin	0.7	1.1	2.4	1.3	1.5	-0.5	-0.8	-1.0	0.7
Fluid intelligence score	1.7	3.5	6.9	2.6	2.0	-1.6	-2.5	-0.7	0.7
Illnesses of siblings	1.6	2.3	4.2	2.0	1.6	-1.3	-0.8	-1.0	1.9
Neuroticism score	2.2	4.5	8.9	2.4	2.8	-1.8	-3.0	-0.5	1.2
Weight	1.2	5.9	8.9	3.0	2.9	-2.6	-1.7	-2.6	1.5
Impedance of arm (right)	2.2	10.3	17.1	-3.4	-3.9	4.1	2.7	0.7	-3.2
Arm fat percentage (right)	0.4	1.7	4.5	0.3	0.9	-0.8	-0.1	-2.1	-2.1
Trunk fat-free mass	1.2	7.0	14.1	3.5	2.3	-2.5	-1.1	-1.6	3.8
Hip circumference	0.5	2.0	4.7	1.2	1.4	-1.7	-0.7	-2.2	-0.4
Time employed in main current job	0.3	0.3	0.8	0.4	-0.6	0.9	-0.1	0.6	0.5
Alcohol intake versus 10 years previously	0.7	1.0	3.6	1.2	0.4	-0.8	-0.5	0.4	1.9
Father’s age at death	0.4	0.6	1.1	-1.0	-0.7	0.7	0.8	0.9	-0.3
Worrier / anxious feelings	2.4	4.6	9.7	2.5	2.3	-1.5	-3.1	0.9	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.7	1.4	1.0	-0.7	-1.9	-1.4	-0.0
Falls in the last year	0.6	0.8	1.0	0.9	0.8	-1.0	-0.9	0.8	1.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.4	-0.8	-0.5	0.8	0.1	-0.3
Number of live births	0.9	1.3	2.8	-0.2	-1.6	1.2	1.7	0.8	-0.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	6.9	2.4	1.4	-1.5	-0.8	-2.6	2.0
Pulse rate	0.6	1.0	2.1	1.4	-0.1	1.0	0.9	0.0	1.5
Happiness	2.2	2.6	8.5	0.2	1.9	-1.0	-2.9	-1.4	0.8
Noisy workplace	0.9	1.1	2.4	-0.2	-0.2	1.6	0.7	-1.5	-1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.5	0.4	0.2	-0.5	-0.6	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	1.2	1.1	-0.6	1.0	-0.0	-0.2	0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	0.5	0.6	-1.2	-0.4	0.7	0.5
Asthma	0.3	0.6	1.8	-1.4	-0.3	1.2	-0.3	-0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.9	-0.4	0.3	0.0	0.4	0.0	1.0
Medication: Cholesterol lowering	0.4	0.6	2.0	0.0	0.4	1.1	0.2	-1.4	-0.2
Depression (self-reported)	2.8	3.4	5.8	2.4	1.5	0.3	-1.7	-1.8	2.4
Medication: Lansoprazole	0.6	0.7	1.6	-0.9	-0.7	-0.2	1.3	-0.8	-0.9
Prospective memory result	1.1	1.3	4.2	-0.2	-0.9	-0.0	1.6	2.0	0.4
Lung cancer (father)	0.9	1.0	2.4	1.4	0.8	-0.7	-1.6	0.3	0.7
Illnesses of mother	0.5	0.6	1.4	0.4	0.8	-1.2	-1.1	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	3.9	1.9	1.0	-1.8	-0.4	-1.7	2.0
Pulse wave Arterial Stiffness index	1.4	1.7	3.8	2.0	1.0	-1.4	-1.5	0.3	0.9
Impedance of arm (left)	1.6	7.6	12.3	-3.1	-3.2	3.5	2.2	1.0	-2.6
Arm fat mass (right)	0.7	2.8	5.9	1.6	2.0	-1.8	-0.9	-2.4	-0.6
Trunk predicted mass	1.2	7.1	14.0	3.6	2.4	-2.5	-1.1	-1.6	3.7
Standing height	0.5	5.2	18.5	3.0	1.1	-0.5	-0.7	-1.2	4.3
Length of working week for main job	0.8	0.9	3.3	0.0	0.8	-1.2	-0.3	-0.2	1.8
Exposure to tobacco smoke at home	0.1	0.2	0.6	-0.7	-0.0	0.1	0.0	0.3	-0.5
Breastfed as a baby	0.9	1.1	3.8	-0.7	0.5	-1.3	-0.4	-0.5	-2.0
Tense / ‘highly strung’	3.6	6.0	10.5	1.9	3.2	-2.7	-3.2	-0.4	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	8.1	1.9	2.8	-1.5	-2.9	-0.5	1.0
Hair/balding pattern: Pattern 4	0.0	0.1	0.2	0.3	-0.1	0.0	-0.1	0.4	0.3
Birth weight of first child	0.4	0.8	1.5	1.2	1.1	-0.8	-0.1	0.3	1.1
Peak expiratory flow (PEF)	1.7	3.9	6.7	1.6	2.2	-2.6	-1.6	-2.2	1.3
Pulse wave reflection index	1.9	2.4	4.4	0.2	1.5	-2.0	-1.9	-2.1	-0.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.5	0.4	1.1	-1.1	-1.2	-0.7	0.6
Loud music exposure frequency	2.9	3.1	6.6	2.6	1.1	-1.9	-0.2	-1.2	2.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.6	1.3	-1.2	1.0	1.9	0.8	1.3
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	3.5	-0.6	1.6	-1.3	-1.9	-1.2	0.4
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.0	0.3	-0.7	-0.0	-0.9	0.4
Medication: Paracetamol	0.5	0.8	2.1	-1.0	0.5	-0.1	-0.6	-0.9	-1.5
Headache pain in last month	2.0	3.4	7.0	2.6	1.7	-0.6	-2.3	-2.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.6	0.5	-0.6	-0.8	0.4	0.7	0.5
Glaucoma (self-reported)	1.7	1.9	6.3	-1.6	-0.7	1.5	-0.1	-0.4	-2.5
Gout (self-reported)	0.2	0.3	0.6	-0.7	-0.1	-0.5	0.5	-0.7	-0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.5	0.9	-0.9	1.1	1.2	1.0	-1.0
Medication: Amlodipine	0.4	0.6	1.3	0.3	0.0	-1.1	-0.1	-1.0	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	-0.7	0.6	0.8	-0.8	-0.2	0.6
Birth weight	0.9	1.9	6.0	2.5	0.4	-1.0	0.7	0.2	2.0
Chronic bronchitis/emphysema (mother)	1.3	1.6	4.2	-2.1	-0.6	0.7	-0.1	2.0	-0.2
High blood pressure (siblings)	1.9	2.7	5.7	-2.0	-1.5	1.4	0.6	1.4	-2.4
Forced vital capacity (FVC), Best measure	0.5	1.9	4.8	1.2	0.4	-0.9	-0.0	-2.1	2.2
Body fat percentage	0.8	3.0	5.7	1.2	2.2	-1.7	-1.3	-2.4	-1.3
Leg fat percentage (right)	1.3	4.8	8.5	1.9	2.9	-2.6	-2.0	-2.3	-0.5
Arm fat-free mass (right)	2.5	12.6	20.3	4.5	3.9	-3.6	-2.4	-1.7	4.3
Exposure to tobacco smoke outside home	0.2	0.3	0.8	0.2	-0.4	-0.3	0.6	0.9	0.6
Comparative body size at age 10	0.3	0.7	2.6	-0.3	-0.3	-1.1	0.7	-0.3	-1.6
Number of full brothers	0.2	0.3	1.1	-0.2	0.2	-0.2	-1.1	-0.4	-0.4
Worry too long after embarrassment	0.4	0.6	1.4	0.2	1.1	-0.5	-1.2	-0.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	7.9	0.8	2.1	-1.2	-2.8	-0.0	0.6
Wheeze or whistling in the chest in last year	0.5	0.9	2.1	1.1	0.5	-0.0	-1.4	-1.4	-0.2
Number of children fathered	0.7	0.8	2.7	-1.6	0.1	1.0	-0.8	-0.1	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.4	0.6	-0.2	-0.5	0.8	0.1
Age at first live birth	0.5	1.0	3.2	1.0	0.9	-0.8	-0.3	-1.8	0.3
Pulse wave peak to peak time	1.2	1.4	3.1	-1.8	-0.9	1.4	1.4	-0.5	-0.7
Health satisfaction	0.2	0.3	1.3	0.3	-0.4	-0.2	-0.2	1.1	0.4
Shortness of breath walking on level ground	0.9	1.1	5.0	0.0	-0.6	0.9	0.1	2.2	-0.6
Qualifications: College or University degree	0.8	2.5	5.5	-0.1	2.1	-1.3	-2.4	-1.6	-0.8
Eye problems/disorders: None of the above	0.2	0.2	0.6	-0.1	-0.7	0.3	0.5	-0.2	0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.4	0.8	-0.5	-0.3	0.0	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.0	0.6	-0.2	-0.7	-0.4	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	1.0	-0.6	0.9	0.1	-0.5	0.3
Neck or shoulder pain in last month	0.5	0.8	3.6	0.1	-0.3	0.3	-0.7	0.5	1.9
Medication: Blood pressure	0.2	0.3	0.6	-0.7	0.8	0.0	-0.4	-0.5	-0.7
Angina (self-reported)	0.7	0.9	2.8	1.2	1.1	0.2	-0.4	-1.7	0.2
Migraine (self-reported)	0.3	0.4	1.3	-0.4	-0.4	0.2	0.7	1.1	-0.4
Medication: Ibuprofen	0.2	0.2	0.6	-0.4	-0.1	0.1	0.1	-0.7	0.7
Medication: Allopurinol	0.2	0.2	0.5	-0.7	-0.1	-0.3	0.5	-0.7	-0.2
Medication: Omeprazole	0.6	0.7	2.6	0.2	0.8	0.3	-1.6	-0.9	0.5
Medication: Seretide 50 evohaler	1.5	1.7	4.1	2.0	1.1	-1.9	-0.3	-0.6	0.9
Mean time to correctly identify matches	2.0	3.8	8.5	-2.9	-2.5	1.1	1.8	0.4	-1.8
Heart disease (mother)	0.1	0.1	0.1	-0.3	-0.3	0.0	0.3	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.4	-0.6	1.8	-1.3	-1.8	-0.3	-1.5
Whole body fat mass	1.2	5.0	8.6	2.0	2.9	-2.4	-1.6	-2.9	-0.1
Leg fat mass (right)	1.3	5.1	8.6	2.3	2.9	-2.6	-1.8	-2.5	0.4
Arm predicted mass (right)	2.7	13.9	20.7	4.5	4.1	-3.8	-2.5	-2.1	4.5
Pulse rate, automated reading	0.3	1.1	2.5	1.4	1.6	0.6	-0.8	-0.7	0.9
Alcohol intake frequency.	0.6	1.5	3.3	-1.1	-1.2	1.7	0.2	1.8	-0.1
Comparative height size at age 10	0.2	1.2	5.6	1.2	-0.2	-0.5	0.2	0.2	2.4
Number of full sisters	1.0	1.2	3.7	-1.9	-0.8	-0.1	-0.2	1.5	-0.8
Suffer from ‘nerves’	0.3	0.4	1.1	0.8	0.2	0.3	-0.7	1.0	-0.4
Overall health rating	0.4	0.8	2.1	1.2	0.9	-0.1	-1.4	0.3	0.6
Chest pain or discomfort	0.4	0.6	2.3	1.0	-0.1	-0.1	-0.3	1.5	0.6
Had major operations	1.8	2.1	5.2	-2.3	-0.8	1.4	0.5	-0.8	-2.0
Age at last live birth	1.0	1.4	2.2	1.5	1.4	-1.1	-1.1	-1.0	1.0
Family relationship satisfaction	0.5	0.7	1.5	0.2	0.4	-0.6	-1.2	0.7	1.2
Leg pain on walking	0.4	0.5	1.9	-0.6	-0.2	-0.3	0.7	0.5	-1.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.3	0.7	0.8	-1.1	-0.5	0.5	1.5
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.8	2.0	1.2	-0.5	-1.1	-0.2	0.8
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	7.7	-0.8	0.8	-2.0	-0.8	2.8	1.0
Medication: Aspirin	0.4	0.6	1.4	-0.2	0.6	-1.0	0.5	1.2	0.7
Supplements: Vitamin C	0.3	0.3	0.8	0.6	0.4	0.9	-0.6	0.1	0.3
Knee pain experienced in last month	1.2	1.8	4.7	0.1	1.9	-2.2	-0.7	-0.5	1.3
Hypertension (Self-reported)	0.5	1.5	3.1	1.8	1.3	-1.6	-1.2	-0.5	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	2.5	0.1	1.4	-0.1	-1.6	-1.3	-0.6
Illnesses of father: Heart disease	1.4	1.9	4.6	-2.0	-1.3	0.5	0.7	-0.4	-2.1
Illnesses of siblings: Diabetes	0.3	0.3	0.9	-0.5	-0.5	0.9	0.5	-0.4	0.4
Smoking status: Previous	0.2	0.3	0.6	0.6	0.6	-0.8	0.0	-0.4	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.6	6.6	0.2	-1.3	2.6	1.5	-0.0	2.2
Whole body fat-free mass	1.2	7.0	13.0	3.6	2.5	-2.4	-1.3	-1.8	3.5
Leg fat-free mass (right)	1.0	5.1	10.1	3.2	2.2	-1.8	-1.5	-1.9	2.6
Arm fat percentage (left)	0.5	2.0	4.5	0.6	1.4	-1.2	-0.7	-2.1	-1.8
Average weekly red wine intake	2.0	3.0	7.1	1.3	1.7	-2.7	-2.0	-1.4	-0.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.6	0.6	0.2	-0.6	0.8	0.3	0.7
Mood swings	3.7	6.7	12.4	1.8	3.4	-3.5	-2.9	-0.7	2.1
Loneliness, isolation	0.9	1.3	3.3	0.7	1.1	0.1	-1.6	-1.8	-0.2
Long-standing illness, disability or infirmity	0.1	0.2	0.5	-0.5	-0.5	0.7	-0.4	0.1	-0.4
Ever had bowel cancer screening	0.3	0.3	0.6	-0.1	0.6	-0.6	-0.8	-0.5	-0.6
Diabetes diagnosed by doctor	0.7	1.1	1.8	1.4	1.2	-1.2	-0.9	0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	3.6	0.7	-1.3	0.6	1.9	1.8	1.2
Friendships satisfaction	3.7	4.6	10.2	1.6	2.5	-2.6	-3.2	-0.3	1.3
Qualifications: nursing, teaching	1.2	1.9	3.5	1.8	1.1	-1.6	-1.9	-0.5	0.9
Commuting to job workplace: Walk	0.2	0.2	1.0	-1.0	0.2	-0.2	-0.3	-0.4	0.1
Eye problems/disorders: Cataract	1.2	1.4	3.8	1.0	1.4	-1.9	-1.1	-0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.7	-0.7	0.8	-1.3	-1.1	0.1	-0.3
Medication for cholesterol	0.3	0.4	1.7	-1.3	0.3	0.3	0.0	-0.1	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	-1.0	-0.5	0.4	0.5	-0.7	-0.6
Back pain experienced in last month	0.4	0.6	1.3	0.5	0.2	-0.1	-0.9	-1.1	1.1
Mineral and other dietary supplements	1.3	1.8	5.9	0.4	-1.0	0.2	0.7	-2.4	-1.8
Breast cancer (self-reported)	0.5	0.6	2.7	0.0	0.4	0.2	-0.5	-0.7	-1.6
Asthma (self-reported)	0.3	0.6	2.2	-1.5	-0.2	1.1	-0.5	-0.3	0.1
Osteoporosis (self-reported)	0.9	1.1	2.6	-1.6	0.7	-1.5	-0.7	0.4	-0.4
Osteoarthritis (self-reported)	0.3	0.4	0.8	-0.9	0.8	-0.7	-0.7	-0.4	0.4
Medication: Aspirin	0.5	0.7	1.7	-0.1	0.9	-1.0	-0.3	1.3	0.5
Medication: Gliclazide	1.0	1.1	2.9	1.7	1.0	-1.0	-0.6	-1.1	0.5
Illnesses of father: None of the above (group 1)	0.1	0.2	0.6	0.1	-0.2	0.8	-0.1	0.7	-0.2
Smoking status: Current	2.3	3.7	5.7	2.4	1.9	-2.4	-1.9	-1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.8	0.0	-0.7	0.0	0.1	-0.2
Whole body water mass	1.2	7.1	13.5	3.7	2.5	-2.3	-1.4	-1.9	3.4
Leg predicted mass (right)	0.9	5.0	10.4	3.2	2.2	-1.7	-1.5	-1.8	2.6
Arm fat mass (left)	0.9	3.7	6.5	1.8	2.5	-2.1	-1.3	-2.5	-0.1
Number of self-reported non-cancer illnesses	0.5	0.8	1.4	0.7	1.0	-1.2	-1.2	-0.7	-0.5
Average weekly champagne plus white wine intake	0.5	0.7	2.1	0.3	-0.7	1.5	0.8	-0.8	-0.6
Miserableness	4.1	7.2	12.2	2.4	3.5	-2.7	-3.1	-2.0	2.1
Guilty feelings	1.6	2.4	3.3	1.8	1.8	-1.7	-1.6	-1.3	0.9
Wears glasses or contact lenses	1.5	1.7	5.8	0.7	1.1	-2.4	-1.5	0.3	0.5
Ever taken oral contraceptive pill	0.7	0.8	1.5	1.1	1.2	0.2	-1.2	0.2	0.9
Hearing aid user	1.4	1.6	2.7	1.3	1.3	-1.6	-1.6	-1.0	0.4
Mother’s age at death	0.8	1.0	3.2	0.8	1.2	-0.2	-0.7	-0.4	1.8
Financial situation satisfaction	3.9	4.8	10.0	1.7	2.6	-1.3	-3.2	-0.9	2.6
Tinnitus: Yes, now most or all of the time	1.4	1.6	3.6	1.2	1.1	-1.0	-1.9	1.1	1.1
Commuting to job workplace: Public transport	0.7	0.9	2.6	-0.7	-1.6	1.1	0.9	0.3	0.2
Eye problems/disorders: Glaucoma	3.3	3.9	12.0	-2.2	-1.3	1.0	1.1	-1.7	-3.5
Medication: Blood pressure	0.6	1.1	3.0	1.7	0.4	-0.6	-0.8	-0.5	-1.6
Pain type(s) experienced in last month: Hip pain	0.9	1.2	3.7	1.1	0.5	-1.4	-0.0	0.3	1.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	5.2	-0.1	1.0	-0.9	-0.7	2.3	2.2
High cholesterol (Self-reported)	0.3	0.6	1.9	0.2	0.4	0.9	0.6	-1.4	-0.4
Medication: Bendroflumethiazide	0.4	0.6	1.4	1.1	0.8	-0.0	-1.2	0.4	0.4
Medication: Paracetamol	0.7	1.1	3.0	-0.8	0.6	-0.5	-0.7	-1.7	-1.4
Medication: Lisinopril	0.3	0.4	1.4	1.2	0.1	0.6	-0.6	0.1	0.3
Medication: Atorvastatin	0.2	0.2	0.8	0.3	-0.0	0.6	0.9	-0.2	-0.1
Illnesses of father: High blood pressure	0.5	0.6	2.4	-0.4	-0.8	-0.2	0.7	1.6	-0.2
Alcohol drinker status: Never	1.4	1.7	3.1	-1.2	-1.8	1.7	1.4	0.1	-0.7
Ever smoked	1.9	3.4	6.8	2.4	1.8	-2.6	-1.2	-0.8	1.6
Basal metabolic rate	1.2	6.6	12.4	3.5	2.5	-2.3	-1.4	-2.0	3.1
Leg fat percentage (left)	1.5	5.4	9.6	2.2	3.1	-2.9	-2.1	-2.2	-0.4
Arm fat-free mass (left)	1.8	8.9	15.4	3.9	3.2	-2.8	-1.8	-1.8	3.7
Number of operations (self-reported)	0.9	1.3	4.2	-2.1	-0.9	-0.3	0.8	0.2	-1.5
Average weekly beer plus cider intake	0.5	0.7	1.5	-1.0	-0.3	0.3	0.5	-1.2	-1.2
Irritability	2.2	3.8	8.0	0.9	1.8	-1.4	-2.3	1.7	2.8
Risk taking	0.5	0.8	1.2	0.3	0.9	-1.1	-0.6	-1.1	1.1
Ever had prostate specific antigen (PSA) test	1.7	2.0	5.7	-1.4	0.4	-0.6	-1.1	-1.6	-2.4
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.2	-0.5	0.5	0.5	0.5	-0.4
Age started oral contraceptive pill	3.4	4.3	8.5	1.9	2.9	-2.2	-2.6	-1.0	1.0
Diastolic blood pressure, automated reading	0.7	2.2	6.6	-2.5	-0.3	0.4	0.1	-0.7	-2.6
Ever depressed for a whole week	0.5	0.6	1.9	-0.1	0.8	-0.5	-0.7	-0.0	1.4
Unable to work because of sickness or disability	0.2	0.3	0.7	0.1	-0.5	0.2	0.4	-0.8	-0.7
Commuting to job workplace: Cycle	0.7	0.8	2.2	-0.4	-0.8	0.4	1.3	-0.1	-1.5
Myopia	0.3	0.4	1.4	-0.6	-0.4	1.2	-0.2	0.0	-0.6
Vascular/heart problems diagnosed by doctor	0.6	1.7	3.3	-1.8	-1.8	1.2	1.3	0.8	0.3
Cholesterol lowering medication	1.4	2.0	3.8	1.8	2.0	-1.7	-1.1	-0.1	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	-0.0	0.2	0.8	-0.9	-0.9	-0.0
Pain experienced in last month	1.3	2.2	3.5	-1.3	-1.7	1.9	1.4	0.9	-1.4
Supplements: Calcium	1.6	1.8	5.0	-1.8	0.2	1.1	-0.9	2.2	-0.7
Basal cell carcinoma (self-reported)	1.8	2.1	5.5	1.1	1.4	-2.3	-1.2	-0.2	1.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	0.7	1.1	-0.5	-0.4	0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	1.0	0.2	0.4	-0.8	-0.2	-1.0	0.3
Heart disease (siblings)	0.7	0.9	2.3	-1.2	-0.6	1.1	-0.1	-0.1	-1.5
Alcohol drinker status: Previous	0.4	0.4	1.0	0.7	-0.3	-0.5	-0.6	0.5	1.0
Pack years of smoking	1.3	2.0	4.8	-1.3	-1.4	1.5	0.9	2.2	0.7
Impedance of whole body	0.8	4.0	7.2	-2.5	-2.2	2.7	1.3	1.1	-1.8
Leg fat mass (left)	1.4	5.4	9.0	2.5	3.0	-2.7	-1.9	-2.5	0.3
Arm predicted mass (left)	1.6	8.0	14.4	3.8	3.1	-2.6	-1.6	-1.9	3.4