Hub : Genes

ME2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0848	0.0324	1.2e-03	0.055	NA	0.043	NA	0.052	3.6e-05	NA	2.4e-04	NA	6.1e-05
2	GTEx	Muscle Skeletal	0.0854	0.0323	7.3e-04	0.031	NA	0.031	NA	0.035	4.8e-04	NA	5.0e-04	NA	2.2e-04
3	GTEx	Testis	0.3640	0.0730	1.5e-09	0.280	NA	0.240	NA	0.277	7.5e-13	NA	5.2e-11	NA	1.1e-12
4	GTEx	Whole Blood	0.3370	0.0610	1.3e-11	0.128	NA	0.167	NA	0.194	8.3e-12	NA	3.4e-15	NA	1.1e-17
5	NTR	Blood	0.0588	0.0129	4.4e-15	0.057	0.051	0.058	0.056	0.059	1.1e-17	4.1e-16	3.5e-18	2.1e-17	2.7e-18
6	YFS	Blood	0.1067	0.0194	4.4e-16	0.053	0.064	0.090	0.086	0.092	6.0e-17	3.9e-20	6.4e-28	1.2e-26	2.4e-28

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.1	0.2	0.9	-0.3	-1.0	-0.3	0.2	0.2	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.5	-0.3	-0.5	0.6	0.6	0.2
Depressed Affect (Nagel 2018)	1.1	2.3	3.6	1.9	1.8	-1.4	1.3	1.8	0.3
Depression (Nagel 2018)	0.9	1.3	2.8	1.5	1.7	-1.1	0.5	1.1	-0.4
Intelligence (Savage-Jansen 2018)	0.9	2.9	4.9	-2.0	-1.5	2.2	-1.0	-1.9	1.2
Neuroticism (Nagel 2018)	1.4	3.4	5.2	2.0	2.3	-2.0	1.5	2.2	-0.3
Schizophrenia (2018)	0.1	0.2	0.3	-0.4	0.4	-0.4	0.6	0.6	0.1
Schizophrenia vs Biploar Disorder	0.2	0.3	1.3	-0.5	1.1	0.1	0.3	0.4	0.2
Worry (Nagel 2018)	0.1	0.3	0.9	0.5	0.9	-0.4	-0.1	0.5	-0.4
Alzheimer’s Disease (in mother)	1.9	2.2	3.7	1.5	1.5	-1.6	1.6	1.9	0.2
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.2	0.3	-0.1	-0.1	0.4	-0.3
Alzheimer’s Disease (including proxy)	1.1	1.6	3.1	1.0	1.5	-1.4	0.8	1.8	-0.3
Crohns Disease (2017)	2.5	5.6	9.3	-3.0	-2.0	3.0	-0.8	-2.5	2.0
Irritable Bowel Disease (IBD)	4.5	10.6	17.0	-3.9	-3.1	4.1	-2.4	-3.8	1.4
Ulcerative Colitis (UC)	4.2	7.9	12.0	-3.1	-2.7	3.5	-2.5	-3.4	0.7
Major Depression (MDD)	0.1	0.1	0.3	0.6	-0.3	-0.2	0.2	0.0	-0.1
Reaction Time	1.1	2.1	3.4	-1.8	-1.2	0.8	-1.7	-1.1	-1.8
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.4	-1.2	-0.8	1.6	-0.4	-1.4	1.1
Breast Cancer	0.1	0.3	1.1	0.0	1.1	0.3	-0.2	-0.1	0.5
Ovarian Cancer	1.2	1.5	3.4	1.9	0.2	-1.4	1.5	1.2	0.4
Prostate Cancer	1.6	2.3	8.0	0.9	-1.4	0.1	1.7	-0.0	2.8
Age at First Birth	2.1	3.1	5.8	1.8	1.5	-1.5	2.4	1.8	1.2
Bipolar Disorder (2011)	0.7	0.7	1.6	-1.3	-1.0	0.8	-0.3	-0.7	0.5
Body Mass Index (BMI) (2010)	0.4	0.6	1.9	-0.2	-1.4	0.4	0.3	-0.6	0.9
Coronary Artery Disease (CAD)	1.2	1.4	2.8	1.1	1.3	-1.4	1.0	1.7	-0.2
Crohns Disease (2012)	1.4	2.2	4.0	-1.9	-1.1	2.0	-0.5	-1.4	1.5
Mean Putamen Volume	0.6	0.7	2.7	-0.3	0.8	-0.4	-0.7	0.5	-1.6
Fasting Glucose	0.7	0.9	2.8	0.6	0.7	-0.3	-1.2	-0.1	-1.7
HbA1C	1.8	2.0	4.6	0.6	1.3	-1.7	1.6	2.1	-0.0
HDL Cholesterol	0.1	0.2	0.6	0.8	0.1	0.0	-0.0	-0.2	0.5
LDL Cholesterol	0.2	0.4	1.2	0.5	1.1	-0.5	0.2	0.6	-0.5
Lupus	1.2	1.9	4.3	1.7	-0.7	-2.1	1.3	1.4	-0.4
Neuroticism (2016)	1.2	1.7	3.1	1.8	1.3	-1.5	0.8	1.5	-0.4
Primary Biliary Cirrhosis	0.9	1.3	3.1	0.9	-0.9	-0.8	1.7	0.6	1.4
Rheumatoid Arthritis	0.2	0.3	1.2	-0.1	-0.3	-0.6	-0.5	0.3	-1.1
Schizophrenia (2014)	0.1	0.3	1.5	-1.2	0.1	0.0	-0.2	0.1	-0.5
Triglycerides	0.1	0.2	0.3	0.4	0.6	-0.4	0.1	0.6	-0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.6	0.3	-0.4	0.1	0.4	-0.4
Ulcerative Colitis	5.2	7.6	10.4	-3.2	-2.4	3.2	-3.0	-3.2	-0.2
Blood Eosinophil Count	2.6	20.4	34.5	-5.9	-4.4	4.9	-4.4	-5.0	-0.1
Blood Platelet Count	0.3	3.8	6.5	2.5	1.9	-2.1	2.0	2.0	0.1
Blood Red Count	0.1	1.4	3.6	0.9	0.4	-0.4	1.8	0.8	1.9
Blood White Count	0.3	2.2	5.9	-2.4	-0.2	1.9	-1.1	-1.6	0.2
Heel T-Score	0.7	5.7	11.0	-2.2	-1.9	2.2	-3.3	-2.6	-1.8
BMI	0.2	1.2	2.1	1.4	0.3	-1.5	0.7	1.0	-1.2
Height	0.5	10.2	18.1	-3.6	-2.5	4.3	-1.3	-3.3	3.4
Waist Hip Ratio (WHR)	0.1	0.4	0.8	0.5	0.5	-0.9	0.2	0.7	-0.8
Systolic Blood Pressure	0.7	3.4	4.9	-2.2	-1.8	1.6	-2.2	-1.9	-1.3
Smoking Status	0.1	0.3	1.5	1.2	0.1	-0.5	0.2	0.2	-0.1
Allergy or Eczema	6.1	16.2	30.0	-5.5	-3.0	4.7	-4.0	-4.4	-0.4
Cardiovascular Disease	1.3	4.4	7.4	-2.0	-2.3	0.8	-2.5	-1.6	-2.7
Hypothyroidism (self reported)	1.3	2.9	5.4	1.9	1.0	-2.3	1.7	2.1	-0.2
Respiratory disease	3.5	7.7	13.5	-3.7	-2.3	3.5	-2.3	-2.9	1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.5	0.8	0.5	0.4	-0.9	0.9	0.9	-0.1
Lung FEV1/FVC ratio	0.0	0.1	0.5	-0.1	0.1	0.7	-0.2	-0.3	-0.1
Lung FVC	0.1	0.7	2.2	-0.9	-0.2	0.3	0.9	0.2	1.5
Neuroticism	1.4	3.3	5.7	2.0	2.4	-1.8	1.6	2.1	0.3
Chronotype (morning person)	0.0	0.1	0.2	-0.2	-0.4	-0.1	0.4	-0.2	0.4
Hair Pigment	0.1	3.3	6.2	1.7	1.5	-2.5	1.2	2.2	-1.5
Tanning	0.0	0.1	0.2	0.2	-0.1	-0.0	0.3	-0.2	0.5
Hand grip strength (left)	0.4	1.0	1.8	-1.3	0.0	1.2	-1.1	-1.1	-0.3
Number of treatments/medications taken	0.7	1.3	3.2	-1.6	-0.3	0.2	-1.2	-0.4	-1.8
Average weekly spirits intake	2.6	3.3	8.2	1.7	2.9	-1.6	1.3	2.1	-0.2
Sensitivity / hurt feelings	1.9	3.3	5.1	1.5	2.1	-2.2	1.7	2.3	-0.3
Frequency of depressed mood in last 2 weeks	3.5	4.9	8.2	2.9	2.3	-2.5	1.7	2.5	-0.5
Hearing difficulty/problems: Yes	0.4	0.7	1.2	-0.8	-0.2	1.1	-1.0	-1.1	-0.0
Relative age of first facial hair	1.0	2.0	3.6	1.9	1.4	-1.2	1.5	1.4	0.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	0.2	-0.4	-0.9	0.5	0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.5	-0.1	0.6	-0.3	0.1	0.7	-0.2
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	-0.1	-0.6	0.5	-1.0	-0.7	-0.8
Systolic blood pressure, automated reading	0.1	0.2	0.3	-0.2	-0.6	0.1	-0.4	-0.3	-0.6
Eye problems/disorders: Diabetes related eye disease	4.8	5.3	7.9	2.6	2.4	-2.6	0.3	2.1	-2.8
Angina	0.6	0.8	2.6	-0.3	-0.6	0.1	-1.1	-0.5	-1.6
Medication for hormone replacement therapy	2.6	2.9	4.1	1.7	1.7	-2.0	0.3	1.9	-1.9
Vitamin and mineral supplements	0.1	0.1	0.5	0.7	-0.2	-0.4	0.0	0.2	-0.2
Supplements: Zinc	0.1	0.1	0.3	0.3	0.5	0.1	0.1	-0.2	0.0
Medication: Co-codamol	0.8	1.0	4.7	0.2	0.3	-0.6	-0.8	0.1	-2.2
Medication: Metformin	0.7	1.0	3.8	0.1	0.6	-0.2	-1.3	0.1	-1.9
Diabetes (father)	0.2	0.2	0.4	-0.1	-0.6	-0.2	0.7	-0.0	0.6
Diabetes (mother)	0.2	0.3	0.7	-0.6	-0.8	0.3	0.2	-0.4	0.6
Severe depression (siblings)	0.1	0.1	0.2	0.4	-0.4	-0.3	0.4	0.1	0.3
Pack years adult smoking proportion	0.4	0.6	1.3	-0.9	0.2	0.8	-1.1	-0.6	-0.8
Impedance of leg (right)	0.1	0.3	1.4	0.1	0.4	0.4	0.2	0.1	1.2
Leg fat-free mass (left)	0.0	0.2	0.9	-0.1	-1.0	0.2	-0.0	-0.6	-0.1
Trunk fat percentage	1.1	4.2	6.7	2.2	1.9	-2.6	1.3	2.5	-1.5
Hand grip strength (right)	0.1	0.2	0.4	-0.6	-0.5	0.4	0.3	-0.5	0.5
Townsend deprivation index at recruitment	3.4	4.8	8.8	-2.0	-3.0	2.4	-0.5	-2.0	2.4
Current tobacco smoking	0.2	0.4	1.7	0.1	-0.5	0.1	0.7	-0.2	1.3
Average weekly fortified wine intake	0.3	0.4	0.5	0.5	0.7	-0.5	0.6	0.7	0.5
Maternal smoking around birth	0.1	0.1	0.4	-0.2	0.3	0.5	-0.6	-0.3	-0.1
Fed-up feelings	1.0	1.8	2.6	1.6	1.5	-1.3	1.2	1.6	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.9	1.4	1.3	-1.3	0.7	1.2	-0.4
Relative age voice broke	0.3	0.5	2.1	0.4	1.4	-0.4	0.3	0.7	-0.2
Taking other prescription medications	0.3	0.4	1.5	-0.6	0.2	-0.5	-0.0	0.5	-1.2
Age when periods started (menarche)	0.1	0.3	1.3	-0.1	-0.2	0.1	0.7	0.1	1.1
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	6.8	2.1	2.3	-2.4	0.3	1.8	-2.6
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.7	12.5	-2.9	-3.5	2.8	-1.3	-2.8	1.3
Tinnitus: Yes, but not now, but have in the past	3.2	3.4	6.3	-2.1	-1.3	2.5	-1.7	-2.1	0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.0	0.6	-0.2	0.0	0.3	0.0
Serious illness, injury or assault to yourself	1.1	1.3	4.5	1.1	0.4	-0.9	-0.8	0.4	-2.1
High blood pressure	1.3	3.7	5.7	-2.1	-2.3	0.7	-2.1	-1.4	-2.4
Hayfever, allergic rhinitis or eczema	5.1	11.1	22.9	-4.8	-2.6	4.0	-2.9	-3.5	0.4
Multivitamins +/- minerals	0.3	0.4	0.7	-0.9	0.1	0.6	-0.8	-0.4	-0.4
Stomach or abdominal pain in last month	0.2	0.2	1.0	0.3	0.1	-0.2	-0.4	-0.3	-1.0
Supplements: Glucosamine	0.2	0.2	0.6	-0.3	0.8	0.5	-0.5	-0.1	-0.2
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	4.3	-2.1	-1.3	1.9	-0.2	-1.5	1.7
Medication: Atenolol	0.4	0.5	1.5	-0.4	-1.2	-0.1	-0.5	-0.6	-0.9
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.2	0.7	-0.4	-0.0	0.5	-0.5
Sitting height	0.4	2.9	5.9	-1.8	-0.8	2.4	-0.9	-2.0	1.6
Chronic bronchitis/emphysema (father)	1.0	1.1	2.1	1.1	1.3	-1.0	0.9	1.4	0.2
High blood pressure (mother)	0.6	0.8	1.7	1.3	-0.1	-0.9	1.2	0.7	0.6
Body mass index (BMI)	0.4	1.7	3.1	1.5	0.6	-1.8	0.6	1.2	-1.7
Impedance of leg (left)	0.1	0.3	0.7	-0.4	0.2	0.8	-0.4	-0.3	0.8
Leg predicted mass (left)	0.0	0.2	0.8	-0.0	-0.9	0.1	0.1	-0.5	-0.1
Trunk fat mass	0.5	2.3	3.7	1.7	1.3	-1.9	1.0	1.8	-1.2
Waist circumference	0.4	1.4	2.4	1.2	1.0	-1.4	0.3	1.2	-1.5
Number of incorrect matches in round	2.8	4.6	6.9	2.6	2.5	-2.4	1.1	2.4	-1.2
Past tobacco smoking	0.4	0.8	1.7	-1.3	-0.7	1.0	-0.2	-0.9	0.8
Alcohol usually taken with meals	0.4	0.6	2.2	0.0	-0.3	-0.1	1.0	0.5	1.5
Nervous feelings	0.6	1.2	3.6	0.7	1.9	-1.0	0.6	1.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	4.8	1.8	1.9	-1.9	-0.1	1.5	-2.2
Hearing difficulty/problems with background noise	1.0	1.6	3.3	1.3	1.8	-1.2	1.1	1.4	0.0
Hair/balding pattern: Pattern 2	1.0	1.2	3.8	-0.3	2.0	-0.7	-0.2	0.9	-1.4
Had menopause	1.2	1.5	2.6	1.2	1.5	-1.3	0.0	1.1	-1.6
Had other major operations	3.2	4.0	6.9	2.2	1.4	-2.6	2.1	2.3	-0.0
Forced vital capacity (FVC)	0.3	1.3	4.2	-2.1	-0.4	1.3	-0.2	-0.9	0.9
Heel bone mineral density (BMD) T-score, automated (right)	2.4	5.4	11.7	-2.5	-3.4	2.4	-0.8	-2.6	1.4
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-0.3	-0.1	0.5	-1.1	-0.8	-1.0
Qualifications: None of the above	0.3	0.6	1.3	1.2	0.2	-1.1	-0.0	0.8	-0.8
Financial difficulties in last 2 years	0.1	0.1	0.1	-0.1	0.1	0.2	-0.4	-0.3	-0.4
Mouth/teeth dental problems	0.9	1.3	2.7	1.6	1.1	-1.4	0.9	1.1	-0.4
Heart attack	1.5	1.9	2.8	-1.7	-1.6	1.3	-1.0	-1.7	-0.4
Allergy	5.4	12.4	26.5	5.2	3.0	-3.9	3.4	3.5	0.2
Pain all over the body in last month	0.8	0.8	1.9	-0.9	-1.4	0.8	-0.8	-1.0	-0.1
Diabetes (self-reported)	0.6	0.9	1.4	1.0	1.0	-1.1	0.0	1.1	-1.2
Hayfever/allergic rhinitis (self-reported)	1.4	1.9	5.1	-1.8	-0.6	1.4	0.4	-0.7	2.3
Medication: Ramipril	0.4	0.6	1.2	0.1	-0.2	-1.1	0.4	1.0	-1.0
Medication: Simvastatin	1.6	2.4	4.3	1.5	1.5	-1.7	-0.1	1.5	-2.1
Fluid intelligence score	0.1	0.1	0.3	-0.6	-0.1	0.4	0.1	-0.3	0.4
Illnesses of siblings	1.0	1.5	4.8	-0.6	-2.2	0.9	0.3	-1.2	1.2
Neuroticism score	2.3	4.7	6.7	2.2	2.6	-2.3	2.1	2.6	0.3
Weight	0.0	0.1	0.3	0.3	-0.2	-0.2	0.1	0.0	-0.5
Impedance of arm (right)	0.3	1.5	3.2	1.1	1.8	-1.0	1.0	1.6	0.5
Arm fat percentage (right)	0.8	3.1	4.8	1.9	1.6	-2.2	0.8	1.9	-1.9
Trunk fat-free mass	0.5	3.0	4.9	-1.8	-2.1	2.0	-1.2	-2.2	0.4
Hip circumference	0.1	0.3	1.3	0.3	0.3	-0.3	-0.3	0.1	-1.1
Time employed in main current job	0.3	0.4	1.9	-0.3	1.4	0.3	0.0	0.2	0.4
Alcohol intake versus 10 years previously	0.4	0.6	1.4	1.2	0.1	-1.0	0.8	0.6	-0.2
Father’s age at death	1.3	1.7	4.7	1.1	2.2	-0.7	1.2	1.3	1.0
Worrier / anxious feelings	0.3	0.6	1.4	-1.2	0.1	0.9	-1.0	-0.8	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.0	1.4	0.9	-0.7	1.2	0.8	0.9
Falls in the last year	0.2	0.2	0.3	0.6	0.4	-0.5	0.3	0.6	-0.3
Hair/balding pattern: Pattern 3	0.7	1.1	2.0	-0.7	-0.6	1.4	-1.2	-1.4	0.1
Number of live births	1.5	2.1	9.0	0.5	0.4	-0.9	-1.6	0.3	-3.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.1	-1.4	-0.7	1.0	0.4	-0.7	1.4
Pulse rate	0.8	1.3	5.8	-0.3	-0.0	1.0	0.8	-0.4	2.4
Happiness	0.5	0.7	1.7	-0.6	-1.1	0.3	0.7	-0.3	1.3
Noisy workplace	0.0	0.0	0.0	0.1	-0.2	0.1	0.1	-0.2	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.0	-1.0	-0.5	0.5	-0.9	-0.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	5.0	1.0	2.2	-1.1	-0.6	1.3	-2.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.5	0.2	-0.1	0.2	0.2	0.3
Asthma	4.3	8.5	15.2	-3.9	-2.7	3.6	-2.3	-3.0	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.6	-1.2	-1.6	1.2	-0.6	-1.5	0.5
Medication: Cholesterol lowering	1.4	2.2	9.0	-0.3	0.2	-0.1	-2.0	-0.2	-3.0
Depression (self-reported)	0.2	0.2	0.5	-0.3	-0.7	-0.4	-0.2	-0.3	-0.7
Medication: Lansoprazole	0.3	0.3	0.9	-1.0	0.7	0.5	-0.4	0.0	-0.2
Prospective memory result	1.0	1.2	2.6	1.6	0.2	-1.5	0.8	1.1	-0.5
Lung cancer (father)	1.3	1.5	2.9	1.5	0.2	-0.7	1.6	0.9	1.7
Illnesses of mother	3.3	4.1	6.3	-2.2	-0.9	2.4	-2.5	-2.4	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.0	-1.0	-1.3	1.0	0.6	-0.6	2.0
Pulse wave Arterial Stiffness index	1.2	1.4	2.5	-1.1	-0.4	1.5	-1.5	-1.6	-0.3
Impedance of arm (left)	0.4	1.8	3.1	1.2	1.6	-1.1	1.3	1.8	0.8
Arm fat mass (right)	0.3	1.3	2.1	1.3	0.7	-1.5	0.5	1.1	-1.4
Trunk predicted mass	0.5	3.0	4.9	-1.8	-2.0	2.0	-1.2	-2.2	0.3
Standing height	0.5	4.8	9.4	-2.3	-1.5	3.1	-1.0	-2.3	2.3
Length of working week for main job	0.8	0.9	2.6	-0.4	-1.2	0.4	0.9	-0.3	1.6
Exposure to tobacco smoke at home	1.0	1.2	3.5	1.9	1.2	-0.9	0.2	0.9	-0.6
Breastfed as a baby	2.1	2.6	4.4	2.1	1.4	-2.0	1.2	1.8	-0.8
Tense / ‘highly strung’	1.5	2.5	4.5	1.3	2.1	-1.9	1.3	1.9	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.2	-0.1	0.3	-0.1	-0.7	0.0	-1.1
Hair/balding pattern: Pattern 4	1.1	2.8	5.3	1.9	0.5	-2.3	1.8	1.9	-0.3
Birth weight of first child	0.5	1.0	2.6	1.6	1.1	-0.9	0.4	0.9	-0.5
Peak expiratory flow (PEF)	0.2	0.6	1.0	-1.0	-1.0	0.8	-0.3	-0.6	0.5
Pulse wave reflection index	0.1	0.1	0.4	-0.1	0.2	-0.1	-0.3	-0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.7	-0.1	0.8	0.4	0.0	0.1	0.4
Loud music exposure frequency	0.3	0.3	0.9	0.9	0.6	-0.4	0.4	0.3	0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	-0.7	-0.3	0.1	0.4	0.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.5	-1.1	-1.2	0.2	-0.6	-0.6	-0.9
Blood clot in the leg (DVT)	1.8	2.4	3.8	-1.3	-1.8	1.4	-2.0	-1.6	-0.8
Medication: Paracetamol	0.4	0.7	1.7	-0.2	-1.2	0.1	0.8	-0.4	1.3
Headache pain in last month	0.5	0.8	1.5	0.5	1.2	-1.0	0.9	1.1	-0.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	5.5	1.6	1.4	-0.4	1.9	0.9	2.3
Glaucoma (self-reported)	0.2	0.3	1.0	-1.0	-0.3	0.4	0.0	-0.2	0.6
Gout (self-reported)	1.3	1.7	7.0	-0.3	-0.4	-0.0	-1.7	-0.5	-2.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.1	1.4	1.4	-2.0	1.1	1.8	-0.8
Medication: Amlodipine	2.5	3.4	5.5	-2.3	-1.2	1.7	-2.3	-1.8	-1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.6	5.5	-2.4	-0.0	1.5	-0.4	-0.7	1.1
Birth weight	1.2	2.5	4.4	-2.1	-1.2	2.1	-1.2	-1.7	0.8
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	0.3	0.7	-0.6	-0.3	0.6	-1.1
High blood pressure (siblings)	1.2	1.8	3.4	1.3	1.8	-1.1	-0.5	1.3	-1.6
Forced vital capacity (FVC), Best measure	0.5	1.9	3.5	-1.9	-1.3	1.6	-0.1	-1.1	1.6
Body fat percentage	0.9	3.7	6.1	2.2	1.6	-2.5	1.2	2.2	-1.5
Leg fat percentage (right)	1.0	3.5	6.1	2.5	1.5	-2.3	1.4	2.1	-1.0
Arm fat-free mass (right)	0.3	1.7	3.4	-1.3	-1.8	1.4	-0.8	-1.7	0.2
Exposure to tobacco smoke outside home	0.5	0.6	1.0	-0.8	-0.9	1.0	-0.5	-0.9	0.5
Comparative body size at age 10	0.2	0.5	2.3	-0.6	-1.5	0.2	0.0	-0.5	0.3
Number of full brothers	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.4	-0.3	0.1
Worry too long after embarrassment	3.0	5.0	10.9	2.4	3.3	-2.2	1.4	2.4	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.6	-0.9	-1.3	0.9	-1.1	-1.0	-0.5
Wheeze or whistling in the chest in last year	0.3	0.5	1.4	-1.2	-0.8	0.7	-0.0	-0.7	0.4
Number of children fathered	2.3	2.6	8.3	-1.7	-1.4	1.1	1.1	-0.5	2.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	-0.7	0.1	0.1	-0.6	0.0	-0.9
Age at first live birth	0.5	0.9	2.0	-0.7	-1.0	1.1	0.0	-0.9	1.4
Pulse wave peak to peak time	0.8	1.0	1.8	0.8	0.4	-1.2	1.3	1.3	0.4
Health satisfaction	1.1	1.5	3.3	-1.8	-1.3	1.3	-0.9	-1.3	0.0
Shortness of breath walking on level ground	0.4	0.4	1.5	-1.2	0.1	0.8	-0.6	-0.3	-0.2
Qualifications: College or University degree	1.1	3.6	5.6	-2.2	-1.2	2.4	-2.1	-2.2	-0.4
Eye problems/disorders: None of the above	0.7	0.9	2.7	-0.1	-1.2	0.2	1.0	-0.0	1.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	0.2	0.2	-0.2	-0.6	-0.0	-0.9
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.0	0.4	0.4	0.0	-0.1	0.3
Medication for pain relief, constipation, heartburn	0.6	1.0	2.0	1.4	1.4	-0.8	0.3	1.0	-0.3
Neck or shoulder pain in last month	1.2	1.7	4.0	-0.1	1.1	-0.3	1.9	1.1	2.0
Medication: Blood pressure	1.9	3.3	5.5	-2.3	-2.3	1.3	-1.8	-1.6	-1.1
Angina (self-reported)	0.6	0.8	2.4	-0.4	-0.7	0.2	-1.1	-0.6	-1.6
Migraine (self-reported)	1.2	1.5	5.4	-1.1	-0.4	0.8	1.1	-0.3	2.3
Medication: Ibuprofen	0.5	0.6	1.9	-0.8	-1.4	0.5	-0.1	-0.9	0.4
Medication: Allopurinol	0.6	0.8	3.4	0.2	0.2	0.0	-1.2	-0.1	-1.9
Medication: Omeprazole	0.9	1.1	2.5	-0.4	-0.3	0.8	-1.6	-1.0	-1.5
Medication: Seretide 50 evohaler	1.0	1.2	2.0	-1.1	-1.0	1.3	-1.1	-1.4	-0.2
Mean time to correctly identify matches	0.7	1.3	3.4	-1.1	-0.7	0.3	-1.4	-0.7	-1.8
Heart disease (mother)	1.3	1.6	2.5	1.4	1.0	-1.5	1.4	1.6	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.7	-0.1	-0.3	0.1	1.5	0.1	2.2
Whole body fat mass	0.4	1.5	2.4	1.5	0.9	-1.6	0.7	1.3	-1.2
Leg fat mass (right)	0.4	1.7	3.2	1.8	0.7	-1.7	1.0	1.3	-1.0
Arm predicted mass (right)	0.3	1.6	3.2	-1.1	-1.8	1.4	-0.8	-1.6	0.2
Pulse rate, automated reading	0.1	0.3	0.8	-0.6	0.3	0.2	0.6	0.1	0.9
Alcohol intake frequency.	0.1	0.3	0.7	0.7	0.0	-0.1	0.7	0.1	0.8
Comparative height size at age 10	0.4	2.4	4.2	-2.0	-1.2	2.0	-0.4	-1.3	1.7
Number of full sisters	0.2	0.2	0.5	0.7	0.2	-0.5	0.1	0.4	-0.4
Suffer from ‘nerves’	0.1	0.1	0.3	0.2	0.6	-0.1	-0.4	0.2	-0.5
Overall health rating	0.4	0.8	1.5	-1.2	-1.2	0.4	0.7	-0.3	1.0
Chest pain or discomfort	0.1	0.2	0.4	-0.4	-0.7	-0.1	-0.3	-0.3	-0.6
Had major operations	0.7	0.8	2.1	-1.4	-0.4	1.0	-0.8	-1.0	-0.2
Age at last live birth	0.6	0.9	1.7	-1.1	-0.7	1.3	-0.7	-1.0	0.8
Family relationship satisfaction	0.3	0.4	1.0	-0.2	0.2	0.3	-1.0	-0.3	-1.0
Leg pain on walking	0.1	0.1	0.2	-0.2	0.1	-0.0	-0.4	0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.6	0.2	0.9	0.0	1.2	0.8	1.6
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.5	-0.0	0.7	-0.2	0.6	0.6	0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.8	-0.5	-1.3	0.4	0.5	-0.4	1.3
Medication: Aspirin	0.8	1.1	2.4	0.8	0.6	-1.6	1.2	1.2	-0.5
Supplements: Vitamin C	0.7	0.8	1.6	-1.2	-0.6	1.0	0.1	-0.9	0.9
Knee pain experienced in last month	0.2	0.3	0.8	-0.9	-0.4	0.3	-0.6	-0.2	-0.8
Hypertension (Self-reported)	1.7	4.8	7.6	-2.5	-2.8	1.2	-2.3	-1.9	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	3.9	-2.0	-0.9	1.5	-0.8	-1.4	0.4
Illnesses of father: Heart disease	0.3	0.5	1.9	0.5	-0.0	-0.6	-0.4	0.1	-1.4
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.1	0.9	0.4	-0.6	0.1	-0.2
Smoking status: Previous	0.3	0.4	1.0	1.0	0.3	-0.6	-0.1	0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	4.1	8.6	14.3	-2.8	-3.1	3.8	-2.3	-3.5	1.3
Whole body fat-free mass	0.2	1.3	2.5	-1.0	-1.6	1.2	-0.8	-1.5	0.0
Leg fat-free mass (right)	0.1	0.4	1.1	-0.5	-1.1	0.5	-0.4	-0.8	-0.3
Arm fat percentage (left)	0.8	3.3	5.5	2.0	1.5	-2.4	1.1	2.1	-1.7
Average weekly red wine intake	0.3	0.4	1.8	0.1	-0.2	-0.3	-0.7	0.4	-1.3
Handedness (chirality/laterality): Left-handed	0.2	0.2	1.1	0.1	1.0	0.0	-0.2	-0.1	-0.5
Mood swings	0.5	0.8	1.6	1.2	1.3	-0.6	0.6	1.1	0.3
Loneliness, isolation	2.8	3.9	5.4	2.1	1.9	-2.1	2.3	2.3	0.6
Long-standing illness, disability or infirmity	0.4	0.6	2.0	-1.2	-1.4	0.2	-0.2	-0.4	-0.2
Ever had bowel cancer screening	0.2	0.2	0.5	-0.0	-0.1	-0.2	0.7	0.3	0.6
Diabetes diagnosed by doctor	0.6	1.1	2.0	1.1	0.6	-1.4	0.7	1.3	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.3	-0.0	-0.5	-0.3	0.0	-0.2	-0.3
Friendships satisfaction	0.2	0.3	0.8	-0.9	0.1	0.5	-0.7	-0.2	-0.4
Qualifications: nursing, teaching	0.4	0.6	2.6	0.2	-0.2	0.5	0.6	-0.0	1.6
Commuting to job workplace: Walk	1.7	1.8	2.5	-1.3	-1.6	1.6	-0.7	-1.4	1.2
Eye problems/disorders: Cataract	0.4	0.5	1.1	-0.7	0.0	1.1	-0.7	-0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.0	-0.1	0.4	0.3	0.7	0.2	1.0
Medication for cholesterol	0.9	1.4	4.7	-0.9	-0.8	1.1	0.7	-0.8	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.5	-0.8	-1.6	0.2	-0.9	-1.0	-1.2
Back pain experienced in last month	0.7	1.0	2.3	0.7	1.5	-1.1	0.7	1.2	-0.3
Mineral and other dietary supplements	0.1	0.2	0.5	-0.1	-0.5	-0.0	-0.6	-0.3	-0.7
Breast cancer (self-reported)	0.7	0.8	2.5	-0.4	0.2	0.3	-1.3	-0.5	-1.6
Asthma (self-reported)	3.9	7.7	14.0	-3.7	-2.4	3.4	-2.4	-2.9	0.8
Osteoporosis (self-reported)	1.0	1.2	2.2	0.9	1.1	-1.4	0.1	1.1	-1.5
Osteoarthritis (self-reported)	0.7	1.0	1.6	-1.0	-0.7	1.3	-0.1	-1.0	1.3
Medication: Aspirin	0.6	0.8	1.7	0.5	0.5	-1.3	1.2	1.1	-0.2
Medication: Gliclazide	0.7	0.8	1.7	-1.0	-0.3	1.3	-0.9	-0.9	0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.4	-0.8	-0.8	1.5	-0.7	-1.3	1.0
Smoking status: Current	0.1	0.2	0.8	0.1	-0.4	0.1	0.5	-0.2	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	5.3	-2.3	-1.2	1.4	-0.6	-1.2	0.4
Whole body water mass	0.3	1.6	2.8	-1.2	-1.7	1.4	-0.9	-1.7	0.0
Leg predicted mass (right)	0.1	0.4	1.1	-0.5	-1.1	0.5	-0.4	-0.8	-0.4
Arm fat mass (left)	0.4	1.5	2.6	1.4	0.8	-1.6	0.8	1.3	-1.2
Number of self-reported non-cancer illnesses	1.8	3.0	5.4	-2.3	-1.8	1.4	-1.9	-1.6	-1.3
Average weekly champagne plus white wine intake	1.3	1.8	3.3	-1.5	-0.8	1.4	-1.8	-1.4	-0.8
Miserableness	1.6	2.8	5.1	1.9	1.0	-1.4	2.3	1.5	1.6
Guilty feelings	2.1	3.2	5.9	1.9	2.4	-1.9	0.9	2.0	-0.9
Wears glasses or contact lenses	0.2	0.2	0.8	0.0	-0.0	-0.9	0.5	0.5	-0.4
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.5	0.4	-0.4	-0.1	0.3	-0.4
Hearing aid user	0.6	0.6	3.2	0.1	0.1	0.5	0.6	0.0	1.8
Mother’s age at death	0.4	0.5	1.0	1.0	0.1	-0.8	1.0	0.5	0.6
Financial situation satisfaction	0.5	0.6	0.8	-0.8	-0.8	0.9	-0.7	-0.9	0.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.5	0.1	-0.9	0.5	0.9	-0.3	1.9
Commuting to job workplace: Public transport	0.2	0.2	0.6	0.1	-0.2	0.4	-0.7	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	-0.2	0.6	0.0	-0.5	0.2	-0.5
Medication: Blood pressure	1.1	2.2	4.5	-1.1	-1.1	0.9	-2.1	-1.2	-1.9
Pain type(s) experienced in last month: Hip pain	3.9	4.9	6.9	2.4	2.5	-2.6	1.0	2.6	-1.7
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.6	1.1	1.2	-1.2	1.0	1.3	0.1
High cholesterol (Self-reported)	1.2	2.1	8.0	0.6	0.9	-1.1	-1.2	0.7	-2.8
Medication: Bendroflumethiazide	2.0	3.0	11.6	-0.2	0.4	0.0	-2.5	-0.5	-3.4
Medication: Paracetamol	0.2	0.4	1.0	-0.2	-0.9	0.3	0.2	-0.5	1.0
Medication: Lisinopril	0.8	1.1	3.9	0.5	0.7	-0.9	-0.8	0.5	-2.0
Medication: Atorvastatin	3.3	4.1	7.0	-2.6	-1.8	1.8	-2.3	-2.1	-1.2
Illnesses of father: High blood pressure	1.4	1.7	3.0	1.2	1.3	-1.7	1.2	1.6	-0.5
Alcohol drinker status: Never	0.1	0.1	0.3	0.2	0.6	-0.3	0.4	0.4	0.1
Ever smoked	0.5	0.9	2.3	1.5	1.0	-0.9	0.2	0.8	-0.7
Basal metabolic rate	0.1	0.8	1.8	-0.7	-1.4	0.9	-0.5	-1.2	-0.1
Leg fat percentage (left)	0.9	3.4	5.2	2.3	1.5	-2.3	1.1	2.0	-1.5
Arm fat-free mass (left)	0.3	1.5	2.6	-1.1	-1.5	1.4	-0.9	-1.6	0.0
Number of operations (self-reported)	0.1	0.1	0.2	-0.5	0.4	-0.3	0.2	0.4	-0.3
Average weekly beer plus cider intake	0.1	0.1	0.4	-0.7	-0.1	0.3	0.2	-0.3	0.4
Irritability	1.0	1.7	2.8	0.9	1.4	-1.7	1.5	1.6	0.1
Risk taking	0.0	0.1	0.1	0.4	0.1	0.3	-0.3	-0.3	-0.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.9	1.4	0.1	-1.2	0.9	1.3	0.3
Fractured/broken bones in last 5 years	1.7	2.2	7.5	-1.0	-2.7	1.1	-0.2	-1.5	1.1
Age started oral contraceptive pill	0.7	0.8	1.5	-0.8	-1.0	1.2	-0.1	-0.8	1.2
Diastolic blood pressure, automated reading	0.2	0.8	2.4	-0.9	-1.5	0.5	-0.2	-1.0	-0.0
Ever depressed for a whole week	0.3	0.3	0.8	-0.5	-0.0	0.9	-0.4	-0.9	0.4
Unable to work because of sickness or disability	0.5	0.7	1.3	0.9	-0.0	-1.1	0.0	0.9	-1.1
Commuting to job workplace: Cycle	0.3	0.4	1.2	1.1	0.9	-0.4	0.2	0.6	0.0
Myopia	2.3	3.3	6.6	-2.0	-2.6	1.8	-0.9	-2.1	0.9
Vascular/heart problems diagnosed by doctor	1.3	3.6	6.0	1.9	2.3	-0.6	2.0	1.4	2.5
Cholesterol lowering medication	0.0	0.1	0.1	0.0	-0.2	-0.2	0.3	0.2	0.4
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.9	-0.3	0.2	0.7	-1.9	-0.9	-2.0
Pain experienced in last month	0.2	0.3	0.7	0.5	-0.3	0.1	-0.8	-0.4	-0.7
Supplements: Calcium	1.4	1.6	3.1	-1.5	-1.0	1.8	-0.7	-1.3	1.0
Basal cell carcinoma (self-reported)	1.1	1.4	2.4	-1.2	-1.0	0.7	-1.5	-1.1	-1.3
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.5	-1.9	-1.8	1.6	-1.1	-1.8	-0.1
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.3	-1.1	-1.7	1.3	-2.1	-1.5	-1.1
Heart disease (siblings)	1.6	2.0	6.2	1.1	2.5	-1.2	0.8	1.5	-0.1
Alcohol drinker status: Previous	0.3	0.3	0.6	0.7	0.8	0.0	0.5	0.4	0.6
Pack years of smoking	0.3	0.5	1.2	-0.6	0.6	0.3	-1.0	-0.1	-1.1
Impedance of whole body	0.1	0.6	1.3	0.5	1.2	-0.3	0.6	0.9	0.9
Leg fat mass (left)	0.3	1.3	2.1	1.4	0.6	-1.4	0.5	1.0	-1.3
Arm predicted mass (left)	0.3	1.5	2.8	-1.1	-1.4	1.4	-1.1	-1.7	-0.3