Hub : Genes

ME2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0848 0.0324 1.2e-03 0.055 NA 0.043 NA 0.052 3.6e-05 NA 2.4e-04 NA 6.1e-05
2 GTEx Muscle Skeletal 0.0854 0.0323 7.3e-04 0.031 NA 0.031 NA 0.035 4.8e-04 NA 5.0e-04 NA 2.2e-04
3 GTEx Testis 0.3640 0.0730 1.5e-09 0.280 NA 0.240 NA 0.277 7.5e-13 NA 5.2e-11 NA 1.1e-12
4 GTEx Whole Blood 0.3370 0.0610 1.3e-11 0.128 NA 0.167 NA 0.194 8.3e-12 NA 3.4e-15 NA 1.1e-17
5 NTR Blood 0.0588 0.0129 4.4e-15 0.057 0.051 0.058 0.056 0.059 1.1e-17 4.1e-16 3.5e-18 2.1e-17 2.7e-18
6 YFS Blood 0.1067 0.0194 4.4e-16 0.053 0.064 0.090 0.086 0.092 6.0e-17 3.9e-20 6.4e-28 1.2e-26 2.4e-28

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.1 0.2 0.9 -0.3 -1.0 -0.3 0.2 0.2 0.2
Bipolar Disorder or Schizophrenia 0.1 0.2 0.3 -0.5 -0.3 -0.5 0.6 0.6 0.2
Depressed Affect (Nagel 2018) 1.1 2.3 3.6 1.9 1.8 -1.4 1.3 1.8 0.3
Depression (Nagel 2018) 0.9 1.3 2.8 1.5 1.7 -1.1 0.5 1.1 -0.4
Intelligence (Savage-Jansen 2018) 0.9 2.9 4.9 -2.0 -1.5 2.2 -1.0 -1.9 1.2
Neuroticism (Nagel 2018) 1.4 3.4 5.2 2.0 2.3 -2.0 1.5 2.2 -0.3
Schizophrenia (2018) 0.1 0.2 0.3 -0.4 0.4 -0.4 0.6 0.6 0.1
Schizophrenia vs Biploar Disorder 0.2 0.3 1.3 -0.5 1.1 0.1 0.3 0.4 0.2
Worry (Nagel 2018) 0.1 0.3 0.9 0.5 0.9 -0.4 -0.1 0.5 -0.4
Alzheimer’s Disease (in mother) 1.9 2.2 3.7 1.5 1.5 -1.6 1.6 1.9 0.2
Alzheimer’s Disease (in father) 0.1 0.1 0.2 -0.2 0.3 -0.1 -0.1 0.4 -0.3
Alzheimer’s Disease (including proxy) 1.1 1.6 3.1 1.0 1.5 -1.4 0.8 1.8 -0.3
Crohns Disease (2017) 2.5 5.6 9.3 -3.0 -2.0 3.0 -0.8 -2.5 2.0
Irritable Bowel Disease (IBD) 4.5 10.6 17.0 -3.9 -3.1 4.1 -2.4 -3.8 1.4
Ulcerative Colitis (UC) 4.2 7.9 12.0 -3.1 -2.7 3.5 -2.5 -3.4 0.7
Major Depression (MDD) 0.1 0.1 0.3 0.6 -0.3 -0.2 0.2 0.0 -0.1
Reaction Time 1.1 2.1 3.4 -1.8 -1.2 0.8 -1.7 -1.1 -1.8
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.4 -1.2 -0.8 1.6 -0.4 -1.4 1.1
Breast Cancer 0.1 0.3 1.1 0.0 1.1 0.3 -0.2 -0.1 0.5
Ovarian Cancer 1.2 1.5 3.4 1.9 0.2 -1.4 1.5 1.2 0.4
Prostate Cancer 1.6 2.3 8.0 0.9 -1.4 0.1 1.7 -0.0 2.8
Age at First Birth 2.1 3.1 5.8 1.8 1.5 -1.5 2.4 1.8 1.2
Bipolar Disorder (2011) 0.7 0.7 1.6 -1.3 -1.0 0.8 -0.3 -0.7 0.5
Body Mass Index (BMI) (2010) 0.4 0.6 1.9 -0.2 -1.4 0.4 0.3 -0.6 0.9
Coronary Artery Disease (CAD) 1.2 1.4 2.8 1.1 1.3 -1.4 1.0 1.7 -0.2
Crohns Disease (2012) 1.4 2.2 4.0 -1.9 -1.1 2.0 -0.5 -1.4 1.5
Mean Putamen Volume 0.6 0.7 2.7 -0.3 0.8 -0.4 -0.7 0.5 -1.6
Fasting Glucose 0.7 0.9 2.8 0.6 0.7 -0.3 -1.2 -0.1 -1.7
HbA1C 1.8 2.0 4.6 0.6 1.3 -1.7 1.6 2.1 -0.0
HDL Cholesterol 0.1 0.2 0.6 0.8 0.1 0.0 -0.0 -0.2 0.5
LDL Cholesterol 0.2 0.4 1.2 0.5 1.1 -0.5 0.2 0.6 -0.5
Lupus 1.2 1.9 4.3 1.7 -0.7 -2.1 1.3 1.4 -0.4
Neuroticism (2016) 1.2 1.7 3.1 1.8 1.3 -1.5 0.8 1.5 -0.4
Primary Biliary Cirrhosis 0.9 1.3 3.1 0.9 -0.9 -0.8 1.7 0.6 1.4
Rheumatoid Arthritis 0.2 0.3 1.2 -0.1 -0.3 -0.6 -0.5 0.3 -1.1
Schizophrenia (2014) 0.1 0.3 1.5 -1.2 0.1 0.0 -0.2 0.1 -0.5
Triglycerides 0.1 0.2 0.3 0.4 0.6 -0.4 0.1 0.6 -0.5
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.3 0.6 0.3 -0.4 0.1 0.4 -0.4
Ulcerative Colitis 5.2 7.6 10.4 -3.2 -2.4 3.2 -3.0 -3.2 -0.2
Blood Eosinophil Count 2.6 20.4 34.5 -5.9 -4.4 4.9 -4.4 -5.0 -0.1
Blood Platelet Count 0.3 3.8 6.5 2.5 1.9 -2.1 2.0 2.0 0.1
Blood Red Count 0.1 1.4 3.6 0.9 0.4 -0.4 1.8 0.8 1.9
Blood White Count 0.3 2.2 5.9 -2.4 -0.2 1.9 -1.1 -1.6 0.2
Heel T-Score 0.7 5.7 11.0 -2.2 -1.9 2.2 -3.3 -2.6 -1.8
BMI 0.2 1.2 2.1 1.4 0.3 -1.5 0.7 1.0 -1.2
Height 0.5 10.2 18.1 -3.6 -2.5 4.3 -1.3 -3.3 3.4
Waist Hip Ratio (WHR) 0.1 0.4 0.8 0.5 0.5 -0.9 0.2 0.7 -0.8
Systolic Blood Pressure 0.7 3.4 4.9 -2.2 -1.8 1.6 -2.2 -1.9 -1.3
Smoking Status 0.1 0.3 1.5 1.2 0.1 -0.5 0.2 0.2 -0.1
Allergy or Eczema 6.1 16.2 30.0 -5.5 -3.0 4.7 -4.0 -4.4 -0.4
Cardiovascular Disease 1.3 4.4 7.4 -2.0 -2.3 0.8 -2.5 -1.6 -2.7
Hypothyroidism (self reported) 1.3 2.9 5.4 1.9 1.0 -2.3 1.7 2.1 -0.2
Respiratory disease 3.5 7.7 13.5 -3.7 -2.3 3.5 -2.3 -2.9 1.0
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.8 0.5 0.4 -0.9 0.9 0.9 -0.1
Lung FEV1/FVC ratio 0.0 0.1 0.5 -0.1 0.1 0.7 -0.2 -0.3 -0.1
Lung FVC 0.1 0.7 2.2 -0.9 -0.2 0.3 0.9 0.2 1.5
Neuroticism 1.4 3.3 5.7 2.0 2.4 -1.8 1.6 2.1 0.3
Chronotype (morning person) 0.0 0.1 0.2 -0.2 -0.4 -0.1 0.4 -0.2 0.4
Hair Pigment 0.1 3.3 6.2 1.7 1.5 -2.5 1.2 2.2 -1.5
Tanning 0.0 0.1 0.2 0.2 -0.1 -0.0 0.3 -0.2 0.5
Hand grip strength (left) 0.4 1.0 1.8 -1.3 0.0 1.2 -1.1 -1.1 -0.3
Number of treatments/medications taken 0.7 1.3 3.2 -1.6 -0.3 0.2 -1.2 -0.4 -1.8
Average weekly spirits intake 2.6 3.3 8.2 1.7 2.9 -1.6 1.3 2.1 -0.2
Sensitivity / hurt feelings 1.9 3.3 5.1 1.5 2.1 -2.2 1.7 2.3 -0.3
Frequency of depressed mood in last 2 weeks 3.5 4.9 8.2 2.9 2.3 -2.5 1.7 2.5 -0.5
Hearing difficulty/problems: Yes 0.4 0.7 1.2 -0.8 -0.2 1.1 -1.0 -1.1 -0.0
Relative age of first facial hair 1.0 2.0 3.6 1.9 1.4 -1.2 1.5 1.4 0.7
Other serious medical condition/disability diagnosed by doctor 0.3 0.3 0.9 0.2 -0.4 -0.9 0.5 0.5 -0.6
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.5 -0.1 0.6 -0.3 0.1 0.7 -0.2
Ever had hysterectomy (womb removed) 0.4 0.4 1.0 -0.1 -0.6 0.5 -1.0 -0.7 -0.8
Systolic blood pressure, automated reading 0.1 0.2 0.3 -0.2 -0.6 0.1 -0.4 -0.3 -0.6
Eye problems/disorders: Diabetes related eye disease 4.8 5.3 7.9 2.6 2.4 -2.6 0.3 2.1 -2.8
Angina 0.6 0.8 2.6 -0.3 -0.6 0.1 -1.1 -0.5 -1.6
Medication for hormone replacement therapy 2.6 2.9 4.1 1.7 1.7 -2.0 0.3 1.9 -1.9
Vitamin and mineral supplements 0.1 0.1 0.5 0.7 -0.2 -0.4 0.0 0.2 -0.2
Supplements: Zinc 0.1 0.1 0.3 0.3 0.5 0.1 0.1 -0.2 0.0
Medication: Co-codamol 0.8 1.0 4.7 0.2 0.3 -0.6 -0.8 0.1 -2.2
Medication: Metformin 0.7 1.0 3.8 0.1 0.6 -0.2 -1.3 0.1 -1.9
Diabetes (father) 0.2 0.2 0.4 -0.1 -0.6 -0.2 0.7 -0.0 0.6
Diabetes (mother) 0.2 0.3 0.7 -0.6 -0.8 0.3 0.2 -0.4 0.6
Severe depression (siblings) 0.1 0.1 0.2 0.4 -0.4 -0.3 0.4 0.1 0.3
Pack years adult smoking proportion 0.4 0.6 1.3 -0.9 0.2 0.8 -1.1 -0.6 -0.8
Impedance of leg (right) 0.1 0.3 1.4 0.1 0.4 0.4 0.2 0.1 1.2
Leg fat-free mass (left) 0.0 0.2 0.9 -0.1 -1.0 0.2 -0.0 -0.6 -0.1
Trunk fat percentage 1.1 4.2 6.7 2.2 1.9 -2.6 1.3 2.5 -1.5
Hand grip strength (right) 0.1 0.2 0.4 -0.6 -0.5 0.4 0.3 -0.5 0.5
Townsend deprivation index at recruitment 3.4 4.8 8.8 -2.0 -3.0 2.4 -0.5 -2.0 2.4
Current tobacco smoking 0.2 0.4 1.7 0.1 -0.5 0.1 0.7 -0.2 1.3
Average weekly fortified wine intake 0.3 0.4 0.5 0.5 0.7 -0.5 0.6 0.7 0.5
Maternal smoking around birth 0.1 0.1 0.4 -0.2 0.3 0.5 -0.6 -0.3 -0.1
Fed-up feelings 1.0 1.8 2.6 1.6 1.5 -1.3 1.2 1.6 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 1.9 1.4 1.3 -1.3 0.7 1.2 -0.4
Relative age voice broke 0.3 0.5 2.1 0.4 1.4 -0.4 0.3 0.7 -0.2
Taking other prescription medications 0.3 0.4 1.5 -0.6 0.2 -0.5 -0.0 0.5 -1.2
Age when periods started (menarche) 0.1 0.3 1.3 -0.1 -0.2 0.1 0.7 0.1 1.1
Bilateral oophorectomy (both ovaries removed) 3.7 4.3 6.8 2.1 2.3 -2.4 0.3 1.8 -2.6
Heel bone mineral density (BMD) T-score, automated (left) 2.9 6.7 12.5 -2.9 -3.5 2.8 -1.3 -2.8 1.3
Tinnitus: Yes, but not now, but have in the past 3.2 3.4 6.3 -2.1 -1.3 2.5 -1.7 -2.1 0.6
Qualifications: CSEs or equivalent 0.1 0.1 0.4 0.0 0.6 -0.2 0.0 0.3 0.0
Serious illness, injury or assault to yourself 1.1 1.3 4.5 1.1 0.4 -0.9 -0.8 0.4 -2.1
High blood pressure 1.3 3.7 5.7 -2.1 -2.3 0.7 -2.1 -1.4 -2.4
Hayfever, allergic rhinitis or eczema 5.1 11.1 22.9 -4.8 -2.6 4.0 -2.9 -3.5 0.4
Multivitamins +/- minerals 0.3 0.4 0.7 -0.9 0.1 0.6 -0.8 -0.4 -0.4
Stomach or abdominal pain in last month 0.2 0.2 1.0 0.3 0.1 -0.2 -0.4 -0.3 -1.0
Supplements: Glucosamine 0.2 0.2 0.6 -0.3 0.8 0.5 -0.5 -0.1 -0.2
Diverticular disease/diverticulitis (self-reported) 2.1 2.5 4.3 -2.1 -1.3 1.9 -0.2 -1.5 1.7
Medication: Atenolol 0.4 0.5 1.5 -0.4 -1.2 -0.1 -0.5 -0.6 -0.9
Medication: Levothyroxine sodium 0.1 0.2 0.5 0.2 0.7 -0.4 -0.0 0.5 -0.5
Sitting height 0.4 2.9 5.9 -1.8 -0.8 2.4 -0.9 -2.0 1.6
Chronic bronchitis/emphysema (father) 1.0 1.1 2.1 1.1 1.3 -1.0 0.9 1.4 0.2
High blood pressure (mother) 0.6 0.8 1.7 1.3 -0.1 -0.9 1.2 0.7 0.6
Body mass index (BMI) 0.4 1.7 3.1 1.5 0.6 -1.8 0.6 1.2 -1.7
Impedance of leg (left) 0.1 0.3 0.7 -0.4 0.2 0.8 -0.4 -0.3 0.8
Leg predicted mass (left) 0.0 0.2 0.8 -0.0 -0.9 0.1 0.1 -0.5 -0.1
Trunk fat mass 0.5 2.3 3.7 1.7 1.3 -1.9 1.0 1.8 -1.2
Waist circumference 0.4 1.4 2.4 1.2 1.0 -1.4 0.3 1.2 -1.5
Number of incorrect matches in round 2.8 4.6 6.9 2.6 2.5 -2.4 1.1 2.4 -1.2
Past tobacco smoking 0.4 0.8 1.7 -1.3 -0.7 1.0 -0.2 -0.9 0.8
Alcohol usually taken with meals 0.4 0.6 2.2 0.0 -0.3 -0.1 1.0 0.5 1.5
Nervous feelings 0.6 1.2 3.6 0.7 1.9 -1.0 0.6 1.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.9 2.9 4.8 1.8 1.9 -1.9 -0.1 1.5 -2.2
Hearing difficulty/problems with background noise 1.0 1.6 3.3 1.3 1.8 -1.2 1.1 1.4 0.0
Hair/balding pattern: Pattern 2 1.0 1.2 3.8 -0.3 2.0 -0.7 -0.2 0.9 -1.4
Had menopause 1.2 1.5 2.6 1.2 1.5 -1.3 0.0 1.1 -1.6
Had other major operations 3.2 4.0 6.9 2.2 1.4 -2.6 2.1 2.3 -0.0
Forced vital capacity (FVC) 0.3 1.3 4.2 -2.1 -0.4 1.3 -0.2 -0.9 0.9
Heel bone mineral density (BMD) T-score, automated (right) 2.4 5.4 11.7 -2.5 -3.4 2.4 -0.8 -2.6 1.4
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 -0.3 -0.1 0.5 -1.1 -0.8 -1.0
Qualifications: None of the above 0.3 0.6 1.3 1.2 0.2 -1.1 -0.0 0.8 -0.8
Financial difficulties in last 2 years 0.1 0.1 0.1 -0.1 0.1 0.2 -0.4 -0.3 -0.4
Mouth/teeth dental problems 0.9 1.3 2.7 1.6 1.1 -1.4 0.9 1.1 -0.4
Heart attack 1.5 1.9 2.8 -1.7 -1.6 1.3 -1.0 -1.7 -0.4
Allergy 5.4 12.4 26.5 5.2 3.0 -3.9 3.4 3.5 0.2
Pain all over the body in last month 0.8 0.8 1.9 -0.9 -1.4 0.8 -0.8 -1.0 -0.1
Diabetes (self-reported) 0.6 0.9 1.4 1.0 1.0 -1.1 0.0 1.1 -1.2
Hayfever/allergic rhinitis (self-reported) 1.4 1.9 5.1 -1.8 -0.6 1.4 0.4 -0.7 2.3
Medication: Ramipril 0.4 0.6 1.2 0.1 -0.2 -1.1 0.4 1.0 -1.0
Medication: Simvastatin 1.6 2.4 4.3 1.5 1.5 -1.7 -0.1 1.5 -2.1
Fluid intelligence score 0.1 0.1 0.3 -0.6 -0.1 0.4 0.1 -0.3 0.4
Illnesses of siblings 1.0 1.5 4.8 -0.6 -2.2 0.9 0.3 -1.2 1.2
Neuroticism score 2.3 4.7 6.7 2.2 2.6 -2.3 2.1 2.6 0.3
Weight 0.0 0.1 0.3 0.3 -0.2 -0.2 0.1 0.0 -0.5
Impedance of arm (right) 0.3 1.5 3.2 1.1 1.8 -1.0 1.0 1.6 0.5
Arm fat percentage (right) 0.8 3.1 4.8 1.9 1.6 -2.2 0.8 1.9 -1.9
Trunk fat-free mass 0.5 3.0 4.9 -1.8 -2.1 2.0 -1.2 -2.2 0.4
Hip circumference 0.1 0.3 1.3 0.3 0.3 -0.3 -0.3 0.1 -1.1
Time employed in main current job 0.3 0.4 1.9 -0.3 1.4 0.3 0.0 0.2 0.4
Alcohol intake versus 10 years previously 0.4 0.6 1.4 1.2 0.1 -1.0 0.8 0.6 -0.2
Father’s age at death 1.3 1.7 4.7 1.1 2.2 -0.7 1.2 1.3 1.0
Worrier / anxious feelings 0.3 0.6 1.4 -1.2 0.1 0.9 -1.0 -0.8 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.0 1.4 0.9 -0.7 1.2 0.8 0.9
Falls in the last year 0.2 0.2 0.3 0.6 0.4 -0.5 0.3 0.6 -0.3
Hair/balding pattern: Pattern 3 0.7 1.1 2.0 -0.7 -0.6 1.4 -1.2 -1.4 0.1
Number of live births 1.5 2.1 9.0 0.5 0.4 -0.9 -1.6 0.3 -3.0
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.1 -1.4 -0.7 1.0 0.4 -0.7 1.4
Pulse rate 0.8 1.3 5.8 -0.3 -0.0 1.0 0.8 -0.4 2.4
Happiness 0.5 0.7 1.7 -0.6 -1.1 0.3 0.7 -0.3 1.3
Noisy workplace 0.0 0.0 0.0 0.1 -0.2 0.1 0.1 -0.2 0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.0 -1.0 -0.5 0.5 -0.9 -0.6 -1.0
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 5.0 1.0 2.2 -1.1 -0.6 1.3 -2.2
Mouth/teeth dental problems: Dentures 0.0 0.1 0.2 0.5 0.2 -0.1 0.2 0.2 0.3
Asthma 4.3 8.5 15.2 -3.9 -2.7 3.6 -2.3 -3.0 1.1
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 2.6 -1.2 -1.6 1.2 -0.6 -1.5 0.5
Medication: Cholesterol lowering 1.4 2.2 9.0 -0.3 0.2 -0.1 -2.0 -0.2 -3.0
Depression (self-reported) 0.2 0.2 0.5 -0.3 -0.7 -0.4 -0.2 -0.3 -0.7
Medication: Lansoprazole 0.3 0.3 0.9 -1.0 0.7 0.5 -0.4 0.0 -0.2
Prospective memory result 1.0 1.2 2.6 1.6 0.2 -1.5 0.8 1.1 -0.5
Lung cancer (father) 1.3 1.5 2.9 1.5 0.2 -0.7 1.6 0.9 1.7
Illnesses of mother 3.3 4.1 6.3 -2.2 -0.9 2.4 -2.5 -2.4 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 4.0 -1.0 -1.3 1.0 0.6 -0.6 2.0
Pulse wave Arterial Stiffness index 1.2 1.4 2.5 -1.1 -0.4 1.5 -1.5 -1.6 -0.3
Impedance of arm (left) 0.4 1.8 3.1 1.2 1.6 -1.1 1.3 1.8 0.8
Arm fat mass (right) 0.3 1.3 2.1 1.3 0.7 -1.5 0.5 1.1 -1.4
Trunk predicted mass 0.5 3.0 4.9 -1.8 -2.0 2.0 -1.2 -2.2 0.3
Standing height 0.5 4.8 9.4 -2.3 -1.5 3.1 -1.0 -2.3 2.3
Length of working week for main job 0.8 0.9 2.6 -0.4 -1.2 0.4 0.9 -0.3 1.6
Exposure to tobacco smoke at home 1.0 1.2 3.5 1.9 1.2 -0.9 0.2 0.9 -0.6
Breastfed as a baby 2.1 2.6 4.4 2.1 1.4 -2.0 1.2 1.8 -0.8
Tense / ‘highly strung’ 1.5 2.5 4.5 1.3 2.1 -1.9 1.3 1.9 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.2 -0.1 0.3 -0.1 -0.7 0.0 -1.1
Hair/balding pattern: Pattern 4 1.1 2.8 5.3 1.9 0.5 -2.3 1.8 1.9 -0.3
Birth weight of first child 0.5 1.0 2.6 1.6 1.1 -0.9 0.4 0.9 -0.5
Peak expiratory flow (PEF) 0.2 0.6 1.0 -1.0 -1.0 0.8 -0.3 -0.6 0.5
Pulse wave reflection index 0.1 0.1 0.4 -0.1 0.2 -0.1 -0.3 -0.2 -0.6
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.7 -0.1 0.8 0.4 0.0 0.1 0.4
Loud music exposure frequency 0.3 0.3 0.9 0.9 0.6 -0.4 0.4 0.3 0.1
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.5 -0.7 -0.3 0.1 0.4 0.1 0.5
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.5 -1.1 -1.2 0.2 -0.6 -0.6 -0.9
Blood clot in the leg (DVT) 1.8 2.4 3.8 -1.3 -1.8 1.4 -2.0 -1.6 -0.8
Medication: Paracetamol 0.4 0.7 1.7 -0.2 -1.2 0.1 0.8 -0.4 1.3
Headache pain in last month 0.5 0.8 1.5 0.5 1.2 -1.0 0.9 1.1 -0.2
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 5.5 1.6 1.4 -0.4 1.9 0.9 2.3
Glaucoma (self-reported) 0.2 0.3 1.0 -1.0 -0.3 0.4 0.0 -0.2 0.6
Gout (self-reported) 1.3 1.7 7.0 -0.3 -0.4 -0.0 -1.7 -0.5 -2.6
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 4.1 1.4 1.4 -2.0 1.1 1.8 -0.8
Medication: Amlodipine 2.5 3.4 5.5 -2.3 -1.2 1.7 -2.3 -1.8 -1.5
Medication: Ventolin 100micrograms inhaler 1.2 1.6 5.5 -2.4 -0.0 1.5 -0.4 -0.7 1.1
Birth weight 1.2 2.5 4.4 -2.1 -1.2 2.1 -1.2 -1.7 0.8
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.3 0.3 0.7 -0.6 -0.3 0.6 -1.1
High blood pressure (siblings) 1.2 1.8 3.4 1.3 1.8 -1.1 -0.5 1.3 -1.6
Forced vital capacity (FVC), Best measure 0.5 1.9 3.5 -1.9 -1.3 1.6 -0.1 -1.1 1.6
Body fat percentage 0.9 3.7 6.1 2.2 1.6 -2.5 1.2 2.2 -1.5
Leg fat percentage (right) 1.0 3.5 6.1 2.5 1.5 -2.3 1.4 2.1 -1.0
Arm fat-free mass (right) 0.3 1.7 3.4 -1.3 -1.8 1.4 -0.8 -1.7 0.2
Exposure to tobacco smoke outside home 0.5 0.6 1.0 -0.8 -0.9 1.0 -0.5 -0.9 0.5
Comparative body size at age 10 0.2 0.5 2.3 -0.6 -1.5 0.2 0.0 -0.5 0.3
Number of full brothers 0.1 0.1 0.2 -0.4 -0.4 0.3 -0.4 -0.3 0.1
Worry too long after embarrassment 3.0 5.0 10.9 2.4 3.3 -2.2 1.4 2.4 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.6 -0.9 -1.3 0.9 -1.1 -1.0 -0.5
Wheeze or whistling in the chest in last year 0.3 0.5 1.4 -1.2 -0.8 0.7 -0.0 -0.7 0.4
Number of children fathered 2.3 2.6 8.3 -1.7 -1.4 1.1 1.1 -0.5 2.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.7 -0.7 0.1 0.1 -0.6 0.0 -0.9
Age at first live birth 0.5 0.9 2.0 -0.7 -1.0 1.1 0.0 -0.9 1.4
Pulse wave peak to peak time 0.8 1.0 1.8 0.8 0.4 -1.2 1.3 1.3 0.4
Health satisfaction 1.1 1.5 3.3 -1.8 -1.3 1.3 -0.9 -1.3 0.0
Shortness of breath walking on level ground 0.4 0.4 1.5 -1.2 0.1 0.8 -0.6 -0.3 -0.2
Qualifications: College or University degree 1.1 3.6 5.6 -2.2 -1.2 2.4 -2.1 -2.2 -0.4
Eye problems/disorders: None of the above 0.7 0.9 2.7 -0.1 -1.2 0.2 1.0 -0.0 1.6
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.7 0.2 0.2 -0.2 -0.6 -0.0 -0.9
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.0 0.4 0.4 0.0 -0.1 0.3
Medication for pain relief, constipation, heartburn 0.6 1.0 2.0 1.4 1.4 -0.8 0.3 1.0 -0.3
Neck or shoulder pain in last month 1.2 1.7 4.0 -0.1 1.1 -0.3 1.9 1.1 2.0
Medication: Blood pressure 1.9 3.3 5.5 -2.3 -2.3 1.3 -1.8 -1.6 -1.1
Angina (self-reported) 0.6 0.8 2.4 -0.4 -0.7 0.2 -1.1 -0.6 -1.6
Migraine (self-reported) 1.2 1.5 5.4 -1.1 -0.4 0.8 1.1 -0.3 2.3
Medication: Ibuprofen 0.5 0.6 1.9 -0.8 -1.4 0.5 -0.1 -0.9 0.4
Medication: Allopurinol 0.6 0.8 3.4 0.2 0.2 0.0 -1.2 -0.1 -1.9
Medication: Omeprazole 0.9 1.1 2.5 -0.4 -0.3 0.8 -1.6 -1.0 -1.5
Medication: Seretide 50 evohaler 1.0 1.2 2.0 -1.1 -1.0 1.3 -1.1 -1.4 -0.2
Mean time to correctly identify matches 0.7 1.3 3.4 -1.1 -0.7 0.3 -1.4 -0.7 -1.8
Heart disease (mother) 1.3 1.6 2.5 1.4 1.0 -1.5 1.4 1.6 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.2 4.7 -0.1 -0.3 0.1 1.5 0.1 2.2
Whole body fat mass 0.4 1.5 2.4 1.5 0.9 -1.6 0.7 1.3 -1.2
Leg fat mass (right) 0.4 1.7 3.2 1.8 0.7 -1.7 1.0 1.3 -1.0
Arm predicted mass (right) 0.3 1.6 3.2 -1.1 -1.8 1.4 -0.8 -1.6 0.2
Pulse rate, automated reading 0.1 0.3 0.8 -0.6 0.3 0.2 0.6 0.1 0.9
Alcohol intake frequency. 0.1 0.3 0.7 0.7 0.0 -0.1 0.7 0.1 0.8
Comparative height size at age 10 0.4 2.4 4.2 -2.0 -1.2 2.0 -0.4 -1.3 1.7
Number of full sisters 0.2 0.2 0.5 0.7 0.2 -0.5 0.1 0.4 -0.4
Suffer from ‘nerves’ 0.1 0.1 0.3 0.2 0.6 -0.1 -0.4 0.2 -0.5
Overall health rating 0.4 0.8 1.5 -1.2 -1.2 0.4 0.7 -0.3 1.0
Chest pain or discomfort 0.1 0.2 0.4 -0.4 -0.7 -0.1 -0.3 -0.3 -0.6
Had major operations 0.7 0.8 2.1 -1.4 -0.4 1.0 -0.8 -1.0 -0.2
Age at last live birth 0.6 0.9 1.7 -1.1 -0.7 1.3 -0.7 -1.0 0.8
Family relationship satisfaction 0.3 0.4 1.0 -0.2 0.2 0.3 -1.0 -0.3 -1.0
Leg pain on walking 0.1 0.1 0.2 -0.2 0.1 -0.0 -0.4 0.2 -0.4
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.6 0.2 0.9 0.0 1.2 0.8 1.6
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.5 -0.0 0.7 -0.2 0.6 0.6 0.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 1.8 -0.5 -1.3 0.4 0.5 -0.4 1.3
Medication: Aspirin 0.8 1.1 2.4 0.8 0.6 -1.6 1.2 1.2 -0.5
Supplements: Vitamin C 0.7 0.8 1.6 -1.2 -0.6 1.0 0.1 -0.9 0.9
Knee pain experienced in last month 0.2 0.3 0.8 -0.9 -0.4 0.3 -0.6 -0.2 -0.8
Hypertension (Self-reported) 1.7 4.8 7.6 -2.5 -2.8 1.2 -2.3 -1.9 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 3.9 -2.0 -0.9 1.5 -0.8 -1.4 0.4
Illnesses of father: Heart disease 0.3 0.5 1.9 0.5 -0.0 -0.6 -0.4 0.1 -1.4
Illnesses of siblings: Diabetes 0.2 0.2 0.8 -0.1 0.9 0.4 -0.6 0.1 -0.2
Smoking status: Previous 0.3 0.4 1.0 1.0 0.3 -0.6 -0.1 0.6 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 4.1 8.6 14.3 -2.8 -3.1 3.8 -2.3 -3.5 1.3
Whole body fat-free mass 0.2 1.3 2.5 -1.0 -1.6 1.2 -0.8 -1.5 0.0
Leg fat-free mass (right) 0.1 0.4 1.1 -0.5 -1.1 0.5 -0.4 -0.8 -0.3
Arm fat percentage (left) 0.8 3.3 5.5 2.0 1.5 -2.4 1.1 2.1 -1.7
Average weekly red wine intake 0.3 0.4 1.8 0.1 -0.2 -0.3 -0.7 0.4 -1.3
Handedness (chirality/laterality): Left-handed 0.2 0.2 1.1 0.1 1.0 0.0 -0.2 -0.1 -0.5
Mood swings 0.5 0.8 1.6 1.2 1.3 -0.6 0.6 1.1 0.3
Loneliness, isolation 2.8 3.9 5.4 2.1 1.9 -2.1 2.3 2.3 0.6
Long-standing illness, disability or infirmity 0.4 0.6 2.0 -1.2 -1.4 0.2 -0.2 -0.4 -0.2
Ever had bowel cancer screening 0.2 0.2 0.5 -0.0 -0.1 -0.2 0.7 0.3 0.6
Diabetes diagnosed by doctor 0.6 1.1 2.0 1.1 0.6 -1.4 0.7 1.3 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.3 -0.0 -0.5 -0.3 0.0 -0.2 -0.3
Friendships satisfaction 0.2 0.3 0.8 -0.9 0.1 0.5 -0.7 -0.2 -0.4
Qualifications: nursing, teaching 0.4 0.6 2.6 0.2 -0.2 0.5 0.6 -0.0 1.6
Commuting to job workplace: Walk 1.7 1.8 2.5 -1.3 -1.6 1.6 -0.7 -1.4 1.2
Eye problems/disorders: Cataract 0.4 0.5 1.1 -0.7 0.0 1.1 -0.7 -0.8 0.3
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 1.0 -0.1 0.4 0.3 0.7 0.2 1.0
Medication for cholesterol 0.9 1.4 4.7 -0.9 -0.8 1.1 0.7 -0.8 2.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 2.5 -0.8 -1.6 0.2 -0.9 -1.0 -1.2
Back pain experienced in last month 0.7 1.0 2.3 0.7 1.5 -1.1 0.7 1.2 -0.3
Mineral and other dietary supplements 0.1 0.2 0.5 -0.1 -0.5 -0.0 -0.6 -0.3 -0.7
Breast cancer (self-reported) 0.7 0.8 2.5 -0.4 0.2 0.3 -1.3 -0.5 -1.6
Asthma (self-reported) 3.9 7.7 14.0 -3.7 -2.4 3.4 -2.4 -2.9 0.8
Osteoporosis (self-reported) 1.0 1.2 2.2 0.9 1.1 -1.4 0.1 1.1 -1.5
Osteoarthritis (self-reported) 0.7 1.0 1.6 -1.0 -0.7 1.3 -0.1 -1.0 1.3
Medication: Aspirin 0.6 0.8 1.7 0.5 0.5 -1.3 1.2 1.1 -0.2
Medication: Gliclazide 0.7 0.8 1.7 -1.0 -0.3 1.3 -0.9 -0.9 0.2
Illnesses of father: None of the above (group 1) 0.9 1.1 2.4 -0.8 -0.8 1.5 -0.7 -1.3 1.0
Smoking status: Current 0.1 0.2 0.8 0.1 -0.4 0.1 0.5 -0.2 0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.8 5.3 -2.3 -1.2 1.4 -0.6 -1.2 0.4
Whole body water mass 0.3 1.6 2.8 -1.2 -1.7 1.4 -0.9 -1.7 0.0
Leg predicted mass (right) 0.1 0.4 1.1 -0.5 -1.1 0.5 -0.4 -0.8 -0.4
Arm fat mass (left) 0.4 1.5 2.6 1.4 0.8 -1.6 0.8 1.3 -1.2
Number of self-reported non-cancer illnesses 1.8 3.0 5.4 -2.3 -1.8 1.4 -1.9 -1.6 -1.3
Average weekly champagne plus white wine intake 1.3 1.8 3.3 -1.5 -0.8 1.4 -1.8 -1.4 -0.8
Miserableness 1.6 2.8 5.1 1.9 1.0 -1.4 2.3 1.5 1.6
Guilty feelings 2.1 3.2 5.9 1.9 2.4 -1.9 0.9 2.0 -0.9
Wears glasses or contact lenses 0.2 0.2 0.8 0.0 -0.0 -0.9 0.5 0.5 -0.4
Ever taken oral contraceptive pill 0.1 0.1 0.3 0.5 0.4 -0.4 -0.1 0.3 -0.4
Hearing aid user 0.6 0.6 3.2 0.1 0.1 0.5 0.6 0.0 1.8
Mother’s age at death 0.4 0.5 1.0 1.0 0.1 -0.8 1.0 0.5 0.6
Financial situation satisfaction 0.5 0.6 0.8 -0.8 -0.8 0.9 -0.7 -0.9 0.2
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.5 0.1 -0.9 0.5 0.9 -0.3 1.9
Commuting to job workplace: Public transport 0.2 0.2 0.6 0.1 -0.2 0.4 -0.7 -0.5 -0.4
Eye problems/disorders: Glaucoma 0.1 0.2 0.4 -0.2 0.6 0.0 -0.5 0.2 -0.5
Medication: Blood pressure 1.1 2.2 4.5 -1.1 -1.1 0.9 -2.1 -1.2 -1.9
Pain type(s) experienced in last month: Hip pain 3.9 4.9 6.9 2.4 2.5 -2.6 1.0 2.6 -1.7
Supplements: Fish oil (including cod liver oil) 0.8 1.1 1.6 1.1 1.2 -1.2 1.0 1.3 0.1
High cholesterol (Self-reported) 1.2 2.1 8.0 0.6 0.9 -1.1 -1.2 0.7 -2.8
Medication: Bendroflumethiazide 2.0 3.0 11.6 -0.2 0.4 0.0 -2.5 -0.5 -3.4
Medication: Paracetamol 0.2 0.4 1.0 -0.2 -0.9 0.3 0.2 -0.5 1.0
Medication: Lisinopril 0.8 1.1 3.9 0.5 0.7 -0.9 -0.8 0.5 -2.0
Medication: Atorvastatin 3.3 4.1 7.0 -2.6 -1.8 1.8 -2.3 -2.1 -1.2
Illnesses of father: High blood pressure 1.4 1.7 3.0 1.2 1.3 -1.7 1.2 1.6 -0.5
Alcohol drinker status: Never 0.1 0.1 0.3 0.2 0.6 -0.3 0.4 0.4 0.1
Ever smoked 0.5 0.9 2.3 1.5 1.0 -0.9 0.2 0.8 -0.7
Basal metabolic rate 0.1 0.8 1.8 -0.7 -1.4 0.9 -0.5 -1.2 -0.1
Leg fat percentage (left) 0.9 3.4 5.2 2.3 1.5 -2.3 1.1 2.0 -1.5
Arm fat-free mass (left) 0.3 1.5 2.6 -1.1 -1.5 1.4 -0.9 -1.6 0.0
Number of operations (self-reported) 0.1 0.1 0.2 -0.5 0.4 -0.3 0.2 0.4 -0.3
Average weekly beer plus cider intake 0.1 0.1 0.4 -0.7 -0.1 0.3 0.2 -0.3 0.4
Irritability 1.0 1.7 2.8 0.9 1.4 -1.7 1.5 1.6 0.1
Risk taking 0.0 0.1 0.1 0.4 0.1 0.3 -0.3 -0.3 -0.0
Ever had prostate specific antigen (PSA) test 0.9 1.0 1.9 1.4 0.1 -1.2 0.9 1.3 0.3
Fractured/broken bones in last 5 years 1.7 2.2 7.5 -1.0 -2.7 1.1 -0.2 -1.5 1.1
Age started oral contraceptive pill 0.7 0.8 1.5 -0.8 -1.0 1.2 -0.1 -0.8 1.2
Diastolic blood pressure, automated reading 0.2 0.8 2.4 -0.9 -1.5 0.5 -0.2 -1.0 -0.0
Ever depressed for a whole week 0.3 0.3 0.8 -0.5 -0.0 0.9 -0.4 -0.9 0.4
Unable to work because of sickness or disability 0.5 0.7 1.3 0.9 -0.0 -1.1 0.0 0.9 -1.1
Commuting to job workplace: Cycle 0.3 0.4 1.2 1.1 0.9 -0.4 0.2 0.6 0.0
Myopia 2.3 3.3 6.6 -2.0 -2.6 1.8 -0.9 -2.1 0.9
Vascular/heart problems diagnosed by doctor 1.3 3.6 6.0 1.9 2.3 -0.6 2.0 1.4 2.5
Cholesterol lowering medication 0.0 0.1 0.1 0.0 -0.2 -0.2 0.3 0.2 0.4
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 3.9 -0.3 0.2 0.7 -1.9 -0.9 -2.0
Pain experienced in last month 0.2 0.3 0.7 0.5 -0.3 0.1 -0.8 -0.4 -0.7
Supplements: Calcium 1.4 1.6 3.1 -1.5 -1.0 1.8 -0.7 -1.3 1.0
Basal cell carcinoma (self-reported) 1.1 1.4 2.4 -1.2 -1.0 0.7 -1.5 -1.1 -1.3
Heart attack/myocardial infarction (self-reported) 1.8 2.3 3.5 -1.9 -1.8 1.6 -1.1 -1.8 -0.1
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 4.3 -1.1 -1.7 1.3 -2.1 -1.5 -1.1
Heart disease (siblings) 1.6 2.0 6.2 1.1 2.5 -1.2 0.8 1.5 -0.1
Alcohol drinker status: Previous 0.3 0.3 0.6 0.7 0.8 0.0 0.5 0.4 0.6
Pack years of smoking 0.3 0.5 1.2 -0.6 0.6 0.3 -1.0 -0.1 -1.1
Impedance of whole body 0.1 0.6 1.3 0.5 1.2 -0.3 0.6 0.9 0.9
Leg fat mass (left) 0.3 1.3 2.1 1.4 0.6 -1.4 0.5 1.0 -1.3
Arm predicted mass (left) 0.3 1.5 2.8 -1.1 -1.4 1.4 -1.1 -1.7 -0.3