TWAS hub - MECOM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.129	0.042	0.0017	0.096	NA	0.066	NA	0.083	8.1e-08	NA	9.1e-06	NA	6.1e-07
2	TCGA	Thyroid Carcinoma	0.102	0.044	0.0044	0.070	0.009	0.051	NA	0.053	2.2e-07	0.041	9.2e-06	NA	6.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Neuroticism	5.6	13.5	14.5	-3.8	-3.5
Blood Platelet Count	5.4	62.5	93.5	5.6	9.7
Pain all over the body in last month	5.2	5.6	5.9	-2.4	-2.3
Neuroticism (2016)	4.3	6.2	9.0	-1.8	-3.0
Lung cancer (father)	4.3	5.0	6.1	2.0	2.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.8	4.8	2.2	2.2
Mean Putamen Volume	3.9	4.4	5.9	-1.7	-2.4
Frequency of tiredness / lethargy in last 2 weeks	3.9	6.3	6.8	-2.4	-2.6
Serious illness, injury or assault to yourself	3.7	4.5	6.6	-1.6	-2.6
Noisy workplace	3.7	4.5	6.0	-1.8	-2.5
Pulse wave peak to peak time	3.6	4.2	5.2	1.8	2.3
Number of operations (self-reported)	3.5	5.2	6.2	-2.0	-2.5
Pain experienced in last month	3.5	5.8	6.3	2.5	2.3
Rheumatoid Arthritis	3.4	4.6	6.1	-2.5	-1.8
Maternal smoking around birth	3.4	4.9	5.1	-2.2	-2.3
Pulse wave Arterial Stiffness index	3.4	4.0	4.7	-1.8	-2.2
Illness, injury, bereavement, stress in last 2 years	3.4	4.1	4.9	2.2	1.8
Number of full sisters	3.1	3.8	4.8	-1.7	-2.2
Worry (Nagel 2018)	3.0	6.4	6.7	-2.6	-2.5
Bipolar Disorder (2011)	3.0	2.9	3.1	1.8	1.6
Alcohol intake versus 10 years previously	3.0	4.6	7.3	-1.4	-2.7
Stomach or abdominal pain in last month	2.9	3.6	4.5	-1.6	-2.1
Diabetes (mother)	2.8	3.5	4.5	2.1	1.6
Wears glasses or contact lenses	2.7	3.2	5.8	-0.8	-2.4
Neuroticism (Nagel 2018)	2.6	6.2	7.9	-2.1	-2.8
Coronary Artery Disease (CAD)	2.6	3.1	5.3	-0.9	-2.3
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	3.9	-2.0	-1.6
Commuting to job workplace: Walk	2.5	2.7	3.4	1.8	1.4
HDL Cholesterol	2.4	4.0	4.5	-1.9	-2.1
Depressed Affect (Nagel 2018)	2.3	4.9	6.5	-1.8	-2.5
Hearing difficulty/problems with background noise	2.3	3.7	4.1	-2.0	-1.8
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.6	2.9	-1.7	-1.5
Length of working week for main job	2.3	2.5	3.1	-1.4	-1.8
Myopia	2.3	3.3	5.3	2.3	1.1
Fed-up feelings	2.2	4.0	5.4	-1.6	-2.3
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	3.6	-1.9	-1.8
Hypothyroidism/myxoedema (self-reported)	2.2	4.2	4.4	2.0	2.1
Angina (self-reported)	2.2	2.9	3.3	1.6	1.8
Medication for hormone replacement therapy	2.1	2.3	3.5	-1.1	-1.9
Number of children fathered	2.1	2.4	4.3	-0.7	-2.1
Pain type(s) experienced in last month: Hip pain	2.1	2.6	4.2	-2.0	-1.0
Ulcerative Colitis (UC)	2.0	3.8	6.1	-2.5	-1.3
Waist Hip Ratio (WHR)	2.0	9.2	11.0	2.7	3.3
Qualifications: CSEs or equivalent	2.0	2.6	2.8	-1.5	-1.7
Neuroticism score	2.0	4.2	4.9	-1.8	-2.2
Diverticular disease/diverticulitis (self-reported)	1.9	2.3	2.5	-1.6	-1.4
Father’s age at death	1.9	2.6	3.3	-1.8	-1.4
Headache pain in last month	1.9	3.2	3.7	-1.9	-1.7
Migraine (self-reported)	1.9	2.4	3.3	-1.8	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	2.9	-1.7	-1.3
Hearing difficulty/problems: Yes	1.8	2.8	4.0	-1.3	-2.0
Lung FEV1/FVC ratio	1.7	8.7	10.9	-3.3	-2.6
Pulse wave reflection index	1.7	2.1	2.8	-1.2	-1.7
Health satisfaction	1.7	2.2	2.3	-1.5	-1.5
Ever had bowel cancer screening	1.7	1.9	2.5	-1.2	-1.6
Angina	1.6	2.1	2.3	1.4	1.5
Severe depression (siblings)	1.6	1.8	1.8	-1.3	-1.3
Mouth/teeth dental problems	1.6	2.4	2.7	1.7	1.4
Medication: Omeprazole	1.6	1.9	2.5	-1.6	-1.1
Age at First Birth	1.5	2.1	2.4	-1.5	-1.4
Birth weight of first child	1.5	2.6	3.0	-1.7	-1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	2.4	-1.5	-1.2
Long-standing illness, disability or infirmity	1.5	2.3	3.3	-1.2	-1.8
Risk taking	1.5	2.1	3.3	-1.0	-1.8
Hand grip strength (left)	1.4	3.6	4.3	-2.1	-1.7
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.4	1.5	1.1
Financial difficulties in last 2 years	1.4	1.8	2.7	-1.7	-1.0
Irritable Bowel Disease (IBD)	1.3	3.1	4.7	-2.2	-1.2
Ulcerative Colitis	1.3	2.0	3.2	-1.8	-0.8
Hypothyroidism (self reported)	1.3	3.0	3.8	1.5	1.9
Tense / ‘highly strung’	1.3	2.1	2.1	-1.5	-1.4
Worry too long after embarrassment	1.3	2.1	2.9	-1.1	-1.7
Overall health rating	1.3	2.7	3.9	-1.2	-2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	3.8	1.3	1.9
Mood swings	1.3	2.3	2.7	-1.4	-1.7
Medication: Ramipril	1.2	1.5	2.0	-1.0	-1.4
Mouth/teeth dental problems: Dentures	1.2	2.0	2.2	-1.5	-1.3
Ever highly irritable/argumentative for 2 days	1.2	1.5	2.9	0.3	-1.7
Average weekly red wine intake	1.2	1.8	1.9	1.3	1.4
Mother’s age at death	1.2	1.5	1.8	1.1	1.3
Diastolic blood pressure, automated reading	1.2	3.7	5.6	-1.3	-2.4
Basal cell carcinoma (self-reported)	1.2	1.4	1.9	-1.4	-1.0
Medication: Simvastatin	1.1	1.6	2.6	1.6	0.8
Body Mass Index (BMI) (2010)	1.0	1.3	1.7	-1.3	-1.0
Ever had hysterectomy (womb removed)	1.0	1.2	1.9	-1.4	-0.6
Systolic blood pressure, automated reading	1.0	2.9	4.7	-1.1	-2.2
Miserableness	1.0	1.7	2.2	-1.1	-1.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	1.8	1.4	0.9
Commuting to job workplace: Cycle	1.0	1.2	2.3	0.4	1.5
Medication: Metformin	0.9	1.3	1.7	-0.9	-1.3
High blood pressure (mother)	0.9	1.2	1.6	-1.3	-0.9
Pulse rate, automated reading	0.9	2.9	4.3	1.2	2.1
Chest pain or discomfort	0.9	1.3	1.4	-1.2	-1.1
Medication: Gliclazide	0.9	1.1	1.5	-1.2	-0.8
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.1	-1.0	-1.0
Medication: Bendroflumethiazide	0.9	1.3	1.7	1.0	1.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	1.1	-1.1	-1.0
Crohns Disease (2017)	0.8	1.7	2.3	-1.5	-1.0
Heel T-Score	0.8	6.2	8.8	-3.0	-1.9
Relative age of first facial hair	0.8	1.6	2.4	-1.5	-0.9
Diabetes (father)	0.8	1.0	1.6	-1.3	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	3.1	-1.8	-0.7
Number of incorrect matches in round	0.8	1.3	2.2	-0.6	-1.5
Qualifications: None of the above	0.8	1.7	2.1	-1.1	-1.5
Medication: Cholesterol lowering	0.8	1.3	2.3	1.5	0.5
Suffer from ‘nerves’	0.8	1.2	1.4	-1.2	-1.0
Illnesses of father: Heart disease	0.8	1.1	2.0	-0.5	-1.4
Friendships satisfaction	0.8	1.0	1.5	1.2	0.7
Irritability	0.8	1.3	2.6	-0.3	-1.6
HbA1C	0.7	0.7	1.5	-0.1	-1.2
LDL Cholesterol	0.7	1.2	2.3	-0.1	1.5
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	1.2	-0.3
Fluid intelligence score	0.7	1.5	1.9	1.1	1.4
Exposure to tobacco smoke outside home	0.7	0.9	1.3	-1.2	-0.6
Neck or shoulder pain in last month	0.7	1.0	1.3	-0.8	-1.1
Comparative height size at age 10	0.7	3.7	4.5	1.7	2.1
Supplements: Vitamin C	0.7	0.9	1.7	1.3	0.1
Medication for cholesterol	0.7	1.1	1.1	1.1	1.0
Alcohol drinker status: Never	0.7	0.8	1.1	0.7	1.1
Schizophrenia (2014)	0.6	1.4	2.5	0.5	1.6
Chronotype (morning person)	0.6	1.5	2.7	1.6	-0.5
Average weekly spirits intake	0.6	0.7	1.4	0.2	1.2
Sensitivity / hurt feelings	0.6	1.1	1.7	-0.7	-1.3
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.0	-1.0	-0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	-0.4	-1.1
Medication: Lansoprazole	0.6	0.6	0.7	-0.7	-0.9
Comparative body size at age 10	0.6	1.5	2.2	1.5	0.9
Eye problems/disorders: None of the above	0.6	0.7	0.7	-0.9	0.8
Alcohol drinker status: Previous	0.6	0.6	1.0	-1.0	-0.5
Major Depression (MDD)	0.5	0.6	0.7	-0.7	-0.8
Type 2 Diabetes (T2D) (2012)	0.5	0.6	0.8	0.9	0.6
Height	0.5	10.0	13.3	2.6	3.6
Medication: Co-codamol	0.5	0.5	0.9	-0.5	0.9
Supplements: Glucosamine	0.5	0.7	1.1	-0.5	-1.0
Had other major operations	0.5	0.6	0.7	-0.7	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.6	0.8	0.8
Shortness of breath walking on level ground	0.5	0.6	0.6	0.8	0.8
Emphysema/chronic bronchitis	0.5	0.6	1.1	-1.0	0.3
Medication: Blood pressure	0.5	0.9	1.6	-0.4	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	1.0	-0.3
Had major operations	0.5	0.6	0.6	-0.8	-0.8
Knee pain experienced in last month	0.5	0.7	0.8	-0.8	-0.9
Illnesses of father: High blood pressure	0.5	0.6	0.8	-0.9	-0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	0.6	-0.8	-0.7
Depression (Nagel 2018)	0.4	0.6	0.9	-1.0	-0.4
Schizophrenia vs Biploar Disorder	0.4	0.6	1.1	-1.0	-0.3
Primary Biliary Cirrhosis	0.4	0.5	1.0	1.0	0.3
Lung FVC	0.4	2.0	2.7	-1.6	-1.1
Impedance of leg (right)	0.4	2.1	2.7	1.6	1.2
Hand grip strength (right)	0.4	1.2	1.7	-1.3	-0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.8	-0.9	0.0
Multivitamins +/- minerals	0.4	0.5	0.5	-0.7	-0.7
Medication: Levothyroxine sodium	0.4	0.6	0.9	0.9	0.6
Impedance of leg (left)	0.4	1.7	2.0	1.4	1.2
Hair/balding pattern: Pattern 2	0.4	0.6	0.6	-0.8	0.7
Allergy	0.4	0.9	1.1	1.1	0.9
Pulse rate	0.4	0.6	1.2	0.2	1.1
Standing height	0.4	3.6	4.2	1.7	2.0
Loud music exposure frequency	0.4	0.5	0.7	-0.5	-0.8
Glaucoma (self-reported)	0.4	0.4	0.9	0.9	-0.0
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	0.3	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-1.0	0.1
Medication: Ibuprofen	0.4	0.5	0.6	0.8	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	0.5	0.6	0.7
Average weekly champagne plus white wine intake	0.4	0.5	0.8	-0.9	-0.4
Medication: Paracetamol	0.4	0.7	1.3	-0.2	-1.1
Average weekly beer plus cider intake	0.4	0.6	0.6	-0.8	-0.8
Heart disease (siblings)	0.4	0.5	0.8	0.5	-0.9
Pack years of smoking	0.4	0.5	0.9	0.4	0.9
Schizophrenia (2018)	0.3	0.6	1.2	0.1	1.1
Ovarian Cancer	0.3	0.4	0.9	-0.9	-0.0
Prostate Cancer	0.3	0.4	0.7	0.9	0.1
Blood Red Count	0.3	3.1	4.6	2.1	1.2
Pack years adult smoking proportion	0.3	0.5	0.8	0.3	0.9
Taking other prescription medications	0.3	0.5	0.9	-0.0	-1.0
Age when periods started (menarche)	0.3	0.6	0.8	-0.7	-0.9
Body mass index (BMI)	0.3	1.5	1.7	-1.1	-1.3
Alcohol usually taken with meals	0.3	0.4	0.8	-0.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.2	-1.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.5	0.5	0.7	0.7
Arm fat percentage (right)	0.3	1.1	1.2	-1.1	-1.0
Time employed in main current job	0.3	0.3	0.4	0.5	-0.7
Falls in the last year	0.3	0.4	0.7	-0.3	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	0.7	-0.8	0.9
Depression (self-reported)	0.3	0.3	0.6	0.8	-0.2
Prospective memory result	0.3	0.3	0.5	0.7	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.8	-1.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	-0.9	0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.7	-0.5	0.8
Medication: Paracetamol	0.3	0.5	1.1	-0.0	-1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	-0.5	0.9
Gout (self-reported)	0.3	0.4	0.7	0.8	-0.3
Wheeze or whistling in the chest in last year	0.3	0.6	1.1	1.1	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.4	-0.8
Family relationship satisfaction	0.3	0.4	0.5	-0.7	-0.5
Arm fat percentage (left)	0.3	1.0	1.2	-1.1	-0.9
Qualifications: nursing, teaching	0.3	0.4	0.7	-0.8	-0.4
Eye problems/disorders: Cataract	0.3	0.4	0.6	0.8	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.8	-0.1	-0.9
Osteoporosis (self-reported)	0.3	0.4	0.8	0.0	-0.9
Medication: Atorvastatin	0.3	0.4	0.6	0.3	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.7	0.3	1.3
Reaction Time	0.2	0.4	0.6	-0.8	0.4
Crohns Disease (2012)	0.2	0.3	0.3	-0.6	-0.6
Lupus	0.2	0.2	0.5	-0.1	-0.7
Triglycerides	0.2	0.3	0.6	0.0	0.8
Smoking Status	0.2	0.6	1.1	-1.1	-0.1
Cardiovascular Disease	0.2	0.5	0.9	-0.4	-0.9
Trunk fat percentage	0.2	0.7	0.8	-0.9	-0.7
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.8	0.3
Average weekly fortified wine intake	0.2	0.2	0.3	0.5	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.6	-0.8	0.1
Relative age voice broke	0.2	0.4	0.4	-0.6	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.5	-0.2
High blood pressure	0.2	0.6	1.1	-0.3	-1.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.6	-0.8	-0.4
Nervous feelings	0.2	0.3	0.3	-0.6	-0.6
Diabetes (self-reported)	0.2	0.4	0.6	-0.4	-0.8
Trunk fat-free mass	0.2	1.0	1.1	1.1	0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.5	-1.2	0.1
Trunk predicted mass	0.2	0.9	1.1	1.1	0.9
Hair/balding pattern: Pattern 4	0.2	0.5	0.8	0.3	-0.9
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.0	-0.7
High blood pressure (siblings)	0.2	0.4	0.4	-0.6	-0.6
Body fat percentage	0.2	0.7	0.7	-0.8	-0.8
Whole body fat mass	0.2	0.7	0.7	-0.8	-0.8
Age at last live birth	0.2	0.3	0.6	-0.8	0.0
Leg pain on walking	0.2	0.2	0.3	-0.5	-0.3
Diabetes diagnosed by doctor	0.2	0.2	0.4	-0.3	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.3	-0.4	-0.6
Back pain experienced in last month	0.2	0.3	0.5	0.7	0.3
Breast cancer (self-reported)	0.2	0.2	0.4	0.6	-0.3
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.7	-0.3
Guilty feelings	0.2	0.4	0.7	-0.2	-0.8
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.7	0.1
Medication: Blood pressure	0.2	0.3	0.4	0.6	0.6
Ever depressed for a whole week	0.2	0.3	0.3	-0.5	-0.6
Cholesterol lowering medication	0.2	0.3	0.4	0.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.3	0.3	-0.6
Leg fat mass (left)	0.2	0.6	1.0	-0.5	-1.0
Bipolar Disorder (2018)	0.1	0.2	0.4	-0.6	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	-0.3	0.8
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.4	0.6	0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.2	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.1	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	0.4	0.5
Breast Cancer	0.1	0.2	0.3	0.5	0.2
Blood Eosinophil Count	0.1	0.4	0.7	0.8	0.3
Blood White Count	0.1	0.4	0.6	0.3	0.8
Systolic Blood Pressure	0.1	0.5	0.9	0.4	-0.9
Allergy or Eczema	0.1	0.2	0.4	-0.6	0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.4	0.3	-0.7
Number of treatments/medications taken	0.1	0.2	0.3	0.0	-0.6
Supplements: Zinc	0.1	0.1	0.1	0.3	-0.0
Current tobacco smoking	0.1	0.2	0.3	-0.6	-0.3
Medication: Atenolol	0.1	0.2	0.3	-0.2	-0.5
Trunk fat mass	0.1	0.2	0.3	-0.6	-0.4
Waist circumference	0.1	0.3	0.4	0.6	0.6
Forced vital capacity (FVC)	0.1	0.5	0.7	-0.5	0.8
Heart attack	0.1	0.1	0.1	0.4	0.1
Illnesses of siblings	0.1	0.1	0.2	-0.1	0.5
Worrier / anxious feelings	0.1	0.2	0.2	0.3	0.4
Illnesses of mother	0.1	0.1	0.2	0.5	-0.2
Arm fat mass (right)	0.1	0.5	0.6	-0.7	-0.7
Breastfed as a baby	0.1	0.1	0.1	-0.3	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.4	-0.5	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.5	0.1
Medication: Amlodipine	0.1	0.2	0.2	0.4	-0.4
Birth weight	0.1	0.1	0.2	-0.4	0.2
Forced vital capacity (FVC), Best measure	0.1	0.4	0.4	-0.6	0.6
Leg fat percentage (right)	0.1	0.4	0.8	-0.0	-0.9
Arm fat-free mass (right)	0.1	0.3	0.4	0.6	0.6
Number of full brothers	0.1	0.2	0.4	-0.0	0.6
Age at first live birth	0.1	0.2	0.2	-0.5	-0.3
Qualifications: College or University degree	0.1	0.3	0.5	0.7	0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.6	0.1
Medication: Allopurinol	0.1	0.1	0.1	0.4	-0.4
Mean time to correctly identify matches	0.1	0.2	0.4	0.0	0.7
Leg fat mass (right)	0.1	0.5	0.9	-0.4	-0.9
Arm predicted mass (right)	0.1	0.4	0.4	0.6	0.6
Alcohol intake frequency.	0.1	0.2	0.2	-0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.1	0.5
Medication: Aspirin	0.1	0.1	0.1	0.3	-0.3
Hypertension (Self-reported)	0.1	0.3	0.7	-0.0	-0.8
Mineral and other dietary supplements	0.1	0.2	0.3	-0.6	-0.1
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.1
Smoking status: Current	0.1	0.2	0.2	-0.5	-0.3
Arm fat mass (left)	0.1	0.5	0.5	-0.7	-0.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.0	-0.7
Ever taken oral contraceptive pill	0.1	0.1	0.1	-0.4	0.2
Hearing aid user	0.1	0.1	0.1	0.0	-0.4
Financial situation satisfaction	0.1	0.2	0.2	-0.4	0.4
Commuting to job workplace: Public transport	0.1	0.2	0.3	0.1	0.6
High cholesterol (Self-reported)	0.1	0.1	0.3	0.5	0.0
Medication: Lisinopril	0.1	0.1	0.2	0.4	0.3
Leg fat percentage (left)	0.1	0.4	0.8	-0.1	-0.9
Age started oral contraceptive pill	0.1	0.1	0.1	-0.3	-0.3
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.1	0.5
Supplements: Calcium	0.1	0.1	0.1	-0.3	0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	0.6	0.2
Impedance of whole body	0.1	0.4	0.6	0.5	0.8
Alzheimer’s Disease (in mother)	0.0	0.1	0.1	0.2	0.3
Fasting Glucose	0.0	0.0	0.1	-0.1	0.3
BMI	0.0	0.2	0.3	-0.3	-0.5
Respiratory disease	0.0	0.1	0.2	-0.4	-0.2
Hair Pigment	0.0	0.4	0.8	0.3	0.9
Tanning	0.0	0.6	0.8	-0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	-0.4	0.1
Vitamin and mineral supplements	0.0	0.0	0.0	-0.1	0.0
Leg fat-free mass (left)	0.0	0.2	0.2	-0.5	-0.3
Sitting height	0.0	0.2	0.4	0.6	-0.0
Leg predicted mass (left)	0.0	0.1	0.2	-0.5	-0.3
Past tobacco smoking	0.0	0.0	0.0	-0.0	0.2
Had menopause	0.0	0.1	0.1	0.1	-0.3
Weight	0.0	0.1	0.1	-0.3	-0.4
Impedance of arm (right)	0.0	0.0	0.0	-0.1	-0.2
Hip circumference	0.0	0.1	0.1	-0.4	-0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	0.1	0.0
Number of live births	0.0	0.1	0.1	0.3	0.2
Happiness	0.0	0.1	0.1	-0.3	0.0
Asthma	0.0	0.1	0.1	0.4	-0.1
Impedance of arm (left)	0.0	0.1	0.1	-0.2	0.2
Exposure to tobacco smoke at home	0.0	0.0	0.0	0.2	-0.1
Medication: Ventolin 100micrograms inhaler	0.0	0.1	0.1	-0.3	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.0	0.1
Heart disease (mother)	0.0	0.0	0.0	0.0	0.0
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.0	-0.3
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.3	0.1
Smoking status: Previous	0.0	0.1	0.1	0.3	-0.0
Whole body fat-free mass	0.0	0.2	0.2	0.5	0.4
Leg fat-free mass (right)	0.0	0.3	0.4	-0.6	-0.3
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.2	0.0
Loneliness, isolation	0.0	0.1	0.1	-0.3	-0.2
Asthma (self-reported)	0.0	0.1	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.0	0.1	-0.3	0.0
Whole body water mass	0.0	0.2	0.2	0.5	0.4
Leg predicted mass (right)	0.0	0.2	0.3	-0.5	-0.2
Ever smoked	0.0	0.0	0.0	0.1	0.2
Basal metabolic rate	0.0	0.0	0.0	0.2	0.2
Arm fat-free mass (left)	0.0	0.2	0.4	0.6	0.3
Fractured/broken bones in last 5 years	0.0	0.1	0.1	-0.3	0.2
Arm predicted mass (left)	0.0	0.2	0.4	0.6	0.3

Hub : Genes

MECOM

Models

Trait associations