TWAS hub - MED13

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0240	2.2e-05	0.064	0.042	0.043	0.05	0.054	2.7e-08	6.9e-06	5.6e-06	8.8e-07	3.8e-07
2	GTEx	Adipose Subcutaneous	0.0750	0.0310	3.5e-03	-0.003	NA	0.014	NA	-0.001	7.3e-01	NA	2.2e-02	NA	4.4e-01
3	GTEx	Breast Mammary Tissue	0.0960	0.0410	3.3e-03	-0.005	NA	0.009	NA	-0.005	8.6e-01	NA	1.1e-01	NA	6.8e-01
4	GTEx	Breast Mammary Tissue (Male)	0.1516	0.0895	3.1e-02	-0.007	NA	-0.007	NA	0.001	4.8e-01	NA	5.2e-01	NA	3.1e-01
5	GTEx	Breast Mammary Tissue (Female)	0.0979	0.0626	3.3e-02	0.030	NA	0.060	NA	0.071	4.4e-02	NA	7.5e-03	NA	3.7e-03
6	GTEx	Cells Transformed fibroblasts	0.0650	0.0350	8.0e-03	0.034	NA	0.004	NA	0.014	1.4e-03	NA	1.4e-01	NA	3.1e-02
7	GTEx	Nerve Tibial	0.1384	0.0492	4.0e-04	0.005	NA	0.026	NA	0.021	1.3e-01	NA	5.6e-03	NA	1.2e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7
Breast Cancer	3.3	7.9	15.7	-3.7	-3.0	-1.4	-0.9	-3.8	-4.0
Medication: Seretide 50 evohaler	3.2	3.7	10.8	3.3	1.4	0.7	1.3	3.2	1.1
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	7.3	2.7	2.1	-0.3	0.0	2.6	2.0
Medication: Atorvastatin	2.7	3.4	8.2	-2.6	-1.7	-0.4	-0.7	-2.9	-2.3
Severe depression (siblings)	2.4	2.7	7.6	-1.5	-1.5	-1.8	-1.1	-1.6	-2.8
Qualifications: College or University degree	2.4	7.7	19.8	3.9	2.0	3.0	0.8	4.4	2.2
Qualifications: None of the above	2.3	4.9	16.3	-2.5	-1.4	-4.0	0.0	-2.6	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	2.3	4.7	8.3	2.8	2.1	1.3	2.5	2.9	2.1
Average weekly red wine intake	2.3	3.4	8.0	2.6	1.3	1.0	1.7	2.8	1.8
Triglycerides	2.2	3.6	7.2	-2.4	-2.7	-0.3	-0.9	-2.4	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	12.2	3.3	1.4	1.3	0.6	3.5	2.9
Supplements: Zinc	2.1	2.3	5.0	-2.0	0.3	-1.3	2.2	-2.2	0.8
Forced expiratory volume in 1-second (FEV1)	2.1	7.2	16.2	3.1	2.3	4.0	2.3	2.4	2.9
Exposure to tobacco smoke outside home	2.1	2.8	8.9	-2.8	-1.2	-1.2	0.4	-3.0	-0.5
Breast cancer (self-reported)	2.0	2.4	7.0	1.5	2.6	1.6	-0.5	1.2	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	12.2	2.7	2.8	3.5	2.5	2.2	2.1
Glaucoma (self-reported)	1.9	2.2	4.0	1.7	2.0	1.6	-0.4	1.9	1.4
Forced vital capacity (FVC)	1.8	7.1	10.5	3.2	2.0	2.9	2.9	2.9	3.1
Financial situation satisfaction	1.8	2.2	9.7	1.1	3.1	0.7	0.0	1.4	1.3
Schizophrenia vs Biploar Disorder	1.7	2.3	7.7	-2.8	-0.5	-0.8	-0.9	-2.5	0.4
Blood Red Count	1.7	16.2	33.1	-5.1	-3.4	-1.8	-3.1	-5.8	-5.5
Relative age voice broke	1.7	2.6	7.7	2.7	1.0	0.7	1.2	2.8	0.8
Systolic blood pressure, automated reading	1.6	4.5	11.5	-2.9	-1.9	-1.4	-0.4	-3.4	-2.4
Medication: Cholesterol lowering	1.6	2.4	4.8	-2.0	-2.2	-0.7	0.1	-2.2	-1.7
Peak expiratory flow (PEF)	1.6	3.7	11.6	2.5	1.4	3.4	0.4	1.8	1.6
Migraine (self-reported)	1.6	2.0	3.7	-1.6	-0.5	0.6	-1.8	-1.9	-1.8
Ever taken oral contraceptive pill	1.6	1.8	5.1	-0.7	-1.3	1.2	1.8	-1.1	-2.3
Diabetes (mother)	1.5	1.9	3.4	1.9	1.8	1.6	-0.3	1.8	0.9
Forced vital capacity (FVC), Best measure	1.5	5.6	11.5	2.6	2.2	2.2	3.4	2.3	2.4
Loneliness, isolation	1.5	2.1	4.5	-1.9	-2.1	-0.8	-1.3	-1.9	-0.2
Ulcerative Colitis	1.4	2.0	4.8	1.6	2.2	-1.9	0.7	1.2	-1.0
Falls in the last year	1.4	1.9	7.8	0.9	1.9	-0.6	0.1	1.0	2.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	5.2	1.2	2.3	0.0	0.0	1.0	2.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	7.5	2.4	0.8	0.9	-0.9	2.7	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	8.0	0.4	2.2	2.8	2.3	0.5	1.5
Bipolar Disorder (2018)	1.3	2.1	3.5	1.9	1.6	0.1	1.7	1.8	1.5
Alzheimer’s Disease (in father)	1.3	1.4	2.8	-1.5	-1.3	-0.1	-0.7	-1.7	-1.7
Heel T-Score	1.3	10.2	24.6	4.2	0.9	2.8	1.0	4.3	5.0
Medication for hormone replacement therapy	1.3	1.4	4.1	1.6	-0.9	0.7	-2.0	1.3	-0.7
Mouth/teeth dental problems: Dentures	1.3	2.2	4.5	-2.1	-1.6	-1.6	-0.6	-2.1	-1.2
Family relationship satisfaction	1.3	1.6	4.7	1.8	2.2	-0.7	1.1	1.0	0.6
Alcohol drinker status: Never	1.3	1.5	5.2	-0.6	-1.4	2.3	-1.7	-0.3	0.3
Average weekly spirits intake	1.2	1.5	3.9	2.0	0.8	-0.8	0.2	1.7	1.5
Medication: Co-codamol	1.2	1.3	6.0	0.4	-0.7	1.5	-2.5	0.3	0.4
Age when periods started (menarche)	1.2	2.8	9.0	3.0	0.9	0.5	-0.4	2.8	1.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.5	1.0	1.5	1.5	-0.6	1.5	1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.7	0.7	-0.2	-2.2	1.9	0.7	0.2
Commuting to job workplace: Walk	1.2	1.3	5.6	-0.7	-0.1	-0.4	-1.4	-0.9	-2.4
Medication: Gliclazide	1.2	1.3	3.8	1.4	0.9	-0.8	-0.6	1.2	1.9
Body Mass Index (BMI) (2010)	1.1	1.5	3.3	-1.3	-1.8	0.4	-1.2	-1.6	-1.1
LDL Cholesterol	1.1	1.8	3.4	-1.5	-1.8	-0.5	-0.4	-1.8	-1.9
Lupus	1.1	1.6	3.3	1.6	0.7	1.6	1.1	1.8	1.3
Townsend deprivation index at recruitment	1.1	1.6	4.8	-1.2	0.8	0.1	-1.7	-1.2	2.2
Supplements: Glucosamine	1.1	1.5	4.4	-2.1	0.2	-1.7	0.3	-1.7	-0.0
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	6.6	-0.7	1.3	1.8	0.2	-0.4	2.6
Pain all over the body in last month	1.1	1.2	4.4	-2.1	-0.8	-0.7	0.1	-1.1	-1.3
Diabetes (self-reported)	1.1	1.6	3.9	1.3	1.1	-0.2	-1.5	1.5	2.0
Length of working week for main job	1.1	1.3	2.6	-1.5	-1.2	0.6	0.5	-1.6	-1.4
Wheeze or whistling in the chest in last year	1.1	1.9	3.7	1.5	1.8	0.9	-0.7	1.9	1.7
Supplements: Vitamin C	1.1	1.3	3.8	-2.0	-0.7	-1.3	-0.4	-1.7	-0.5
Guilty feelings	1.1	1.6	3.5	-0.7	-1.5	-1.9	1.1	-1.1	1.6
Eye problems/disorders: Glaucoma	1.1	1.3	4.1	1.7	1.5	-0.1	0.0	2.0	0.1
Commuting to job workplace: Cycle	1.1	1.3	4.6	1.1	1.1	0.2	-1.0	1.0	2.1
Alzheimer’s Disease (in mother)	1.0	1.2	4.6	2.1	-0.6	0.2	0.4	1.7	0.6
Hand grip strength (right)	1.0	2.8	9.7	3.1	0.4	1.1	-0.2	2.9	0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.3	6.5	2.3	0.1	1.1	-0.1	2.5	1.8
Alcohol usually taken with meals	1.0	1.6	4.0	1.9	1.0	-0.0	0.7	2.0	1.6
Had menopause	1.0	1.2	3.6	-1.4	-1.1	-1.9	-0.0	-1.1	-0.6
Medication: Lansoprazole	1.0	1.2	2.4	-1.0	-0.4	1.2	-1.5	-0.9	-1.6
Standing height	1.0	9.9	29.5	5.4	0.8	1.0	2.7	5.0	2.4
Blood clot in the leg (DVT)	1.0	1.3	5.6	0.4	-1.0	-0.4	-2.4	0.4	-1.4
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	4.2	1.2	2.1	1.3	1.0	1.5	1.1
Heart disease (mother)	1.0	1.2	2.5	1.1	1.4	-1.2	1.0	1.6	0.5
Alcohol intake frequency.	1.0	2.4	6.1	-2.5	-1.6	0.5	-1.0	-2.5	-1.0
Diabetes diagnosed by doctor	1.0	1.6	6.3	1.3	0.7	-0.4	-0.7	1.5	2.5
Eye problems/disorders: Cataract	1.0	1.1	3.8	-0.1	1.4	-1.9	-1.1	0.5	0.8
Osteoporosis (self-reported)	1.0	1.3	4.1	-1.3	0.7	0.1	-2.0	-0.9	-1.4
Hearing aid user	1.0	1.1	5.6	-0.7	-0.2	-1.2	-0.5	-0.3	-2.4
Risk taking	1.0	1.4	4.8	-0.0	-0.0	2.2	2.1	0.0	0.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	5.5	0.0	-1.1	-0.3	-2.4	-0.1	-1.3
Alzheimer’s Disease (including proxy)	0.9	1.2	6.7	-0.4	-2.6	-0.1	-0.2	-0.8	-1.0
HbA1C	0.9	1.0	3.5	-1.9	-0.7	0.1	0.1	-1.6	0.1
HDL Cholesterol	0.9	1.4	6.4	0.3	0.9	-2.5	1.1	0.4	1.1
Height	0.9	16.6	48.3	7.0	0.7	0.2	3.6	6.3	3.8
Waist Hip Ratio (WHR)	0.9	3.9	8.7	-2.8	-2.2	-1.2	-0.0	-3.0	-2.2
Smoking Status	0.9	2.2	6.0	-0.1	-1.7	-1.0	-2.5	0.3	-2.3
Ever had hysterectomy (womb removed)	0.9	1.0	3.5	-0.5	-1.6	0.0	-0.1	-0.8	-1.9
Allergy	0.9	2.2	5.2	-1.8	-1.4	1.7	-1.4	-2.3	-0.1
Lung cancer (father)	0.9	1.1	3.1	0.9	0.1	1.7	-0.5	0.6	1.8
Illnesses of mother	0.9	1.2	3.6	-0.4	-1.6	0.0	-1.3	-0.5	-1.9
Had major operations	0.9	1.0	2.2	-1.3	-1.5	-0.4	1.3	-1.1	-0.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.3	-1.8	-1.2	-1.0	-0.4	-1.4	0.9
Number of operations (self-reported)	0.9	1.4	3.0	-1.7	-1.3	-0.8	0.7	-1.6	-1.2
Diastolic blood pressure, automated reading	0.9	2.8	10.8	-2.5	-0.8	-1.2	0.3	-3.3	-0.5
Myopia	0.9	1.3	6.8	0.1	0.4	2.6	1.1	0.1	0.9
Heart disease (siblings)	0.9	1.1	2.3	0.8	1.5	-1.4	0.9	1.2	0.1
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.5	1.9	1.5	0.9	-1.8	1.9	0.8
Fasting Glucose	0.8	1.0	3.6	1.1	-0.7	0.9	-0.6	0.8	1.9
Frequency of depressed mood in last 2 weeks	0.8	1.1	3.0	-1.3	0.1	0.6	-1.3	-1.0	1.7
Average weekly fortified wine intake	0.8	1.0	1.7	1.1	1.3	1.0	0.4	1.3	1.1
Multivitamins +/- minerals	0.8	1.0	2.8	0.4	1.2	-0.7	1.2	0.7	1.7
Chronic bronchitis/emphysema (father)	0.8	1.0	4.0	0.8	-2.0	-0.0	-1.4	0.3	-0.5
Hair/balding pattern: Pattern 2	0.8	1.1	2.6	1.6	1.0	0.9	0.1	1.6	-0.8
Loud music exposure frequency	0.8	0.9	4.7	0.5	0.1	-2.2	1.0	0.1	0.6
High blood pressure (siblings)	0.8	1.1	2.5	-1.2	-1.4	-0.4	0.8	-1.1	-1.6
Leg fat percentage (right)	0.8	2.7	7.1	-2.7	-0.3	-1.5	-1.0	-2.5	-1.6
Eye problems/disorders: None of the above	0.8	0.9	4.1	0.3	-0.8	2.0	-0.4	-0.4	-1.1
Medication: Ibuprofen	0.8	1.0	2.6	0.9	1.6	-0.2	0.2	1.0	1.5
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	2.1	-1.4	-0.9	1.0	-0.6	-1.5	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.0	-1.7	-1.1	0.2	0.7	-1.4	0.2
Mood swings	0.8	1.5	5.3	0.4	2.3	-0.3	-0.7	0.8	1.9
Qualifications: nursing, teaching	0.8	1.2	5.3	-0.6	0.9	0.6	2.3	0.1	1.2
Back pain experienced in last month	0.8	1.2	3.3	1.1	1.4	0.8	-0.5	0.8	1.8
Mother’s age at death	0.8	1.0	4.1	-0.5	-1.5	-0.4	0.0	-0.4	-2.0
Ever smoked	0.8	1.3	4.9	1.2	0.5	-0.8	-2.2	1.3	-0.3
Bipolar Disorder (2011)	0.7	0.6	1.9	1.1	1.4	-0.4	0.0	1.0	-0.5
Lung FEV1/FVC ratio	0.7	3.6	14.4	2.0	1.8	3.8	-1.2	1.4	0.1
Chronotype (morning person)	0.7	1.5	4.1	-2.0	-0.9	-1.1	0.3	-2.0	-0.6
Maternal smoking around birth	0.7	1.0	3.8	-0.5	-1.3	0.0	-1.9	-0.7	-0.8
Fed-up feelings	0.7	1.3	3.3	0.7	1.3	0.5	-1.6	0.9	1.8
Qualifications: CSEs or equivalent	0.7	0.9	1.5	-1.2	-1.1	-0.4	1.1	-1.2	-0.8
Serious illness, injury or assault to yourself	0.7	0.8	2.1	-0.7	0.2	-1.4	1.4	-0.3	-1.1
Hair/balding pattern: Pattern 3	0.7	1.0	2.7	1.1	1.6	-0.2	0.7	0.8	1.4
Happiness	0.7	0.9	2.6	1.2	1.6	0.2	-0.3	0.2	1.4
Mouth/teeth dental problems: Bleeding gums	0.7	1.0	2.3	1.5	0.7	-0.4	0.0	1.3	1.5
Headache pain in last month	0.7	1.2	5.2	0.6	0.8	1.3	0.1	0.7	2.3
Comparative body size at age 10	0.7	1.8	6.2	-2.5	-0.8	-0.2	0.7	-2.2	-0.6
Worry too long after embarrassment	0.7	1.2	7.2	-0.4	0.1	1.0	0.5	-0.2	2.7
Mouth/teeth dental problems: Loose teeth	0.7	0.9	2.0	1.2	0.5	-0.8	-1.4	1.1	-0.6
Emphysema/chronic bronchitis	0.7	0.8	1.9	1.3	1.4	-0.9	0.2	1.2	0.1
Long-standing illness, disability or infirmity	0.7	1.1	2.9	1.1	0.6	-0.1	-1.7	1.4	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.1	-0.1	-0.5	-1.4	1.1	0.1	1.5
Average weekly champagne plus white wine intake	0.7	1.0	2.4	1.5	1.1	0.2	1.0	1.5	0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.1	-0.4	1.6	-0.0	-0.2	-0.1	1.8
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.3	1.1	0.4	1.5	-0.2	0.8	1.3
Leg fat percentage (left)	0.7	2.6	7.1	-2.7	-0.4	-1.3	-0.6	-2.5	-1.6
Average weekly beer plus cider intake	0.7	1.0	3.3	0.8	1.8	-0.2	1.4	0.6	0.8
Schizophrenia (2018)	0.6	1.3	3.3	-1.4	-1.4	1.0	0.7	-1.8	-0.7
Ulcerative Colitis (UC)	0.6	1.1	3.4	1.0	1.8	-1.1	0.9	0.4	-1.1
Age at First Birth	0.6	0.9	3.6	-1.1	-0.2	0.8	1.9	-0.7	0.7
Neuroticism (2016)	0.6	0.8	1.7	1.2	-0.7	-0.8	-0.7	1.1	1.3
Relative age of first facial hair	0.6	1.2	3.1	1.8	0.6	0.4	0.6	1.6	1.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	3.4	0.7	-0.4	0.0	-1.8	0.4	0.8
Stomach or abdominal pain in last month	0.6	0.8	2.8	-0.5	-1.5	-0.1	-1.7	-0.5	0.2
High blood pressure (mother)	0.6	0.8	1.6	1.2	0.8	0.8	1.1	0.5	1.3
Past tobacco smoking	0.6	1.1	4.0	-1.1	0.4	0.8	2.0	-1.0	1.0
Nervous feelings	0.6	1.1	3.6	1.5	0.5	0.3	-0.8	1.0	1.9
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.7	-0.5	0.7	0.1	-1.6	-0.4	1.9
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.5	1.3	1.0	-0.2	1.0	1.2	1.9
Asthma	0.6	1.2	5.9	0.8	-0.3	-2.4	0.7	1.0	-0.4
Depression (self-reported)	0.6	0.7	2.6	-1.6	0.3	0.2	-0.4	-1.1	-0.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.2	-1.2	0.3	-0.8	-0.1	-1.5	0.4
Mean time to correctly identify matches	0.6	1.0	2.8	-1.5	-0.7	-0.8	1.0	-1.7	0.5
Leg pain on walking	0.6	0.7	3.3	0.4	1.0	0.5	-0.8	0.2	1.8
Medication: Aspirin	0.6	0.7	1.5	-0.6	-1.2	-0.7	-1.1	-0.5	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.8	-0.0	-0.0	0.4	-1.7	-0.3	-1.3
Medication for cholesterol	0.6	0.8	3.8	-0.4	0.1	-1.9	1.4	-0.3	-0.1
Asthma (self-reported)	0.6	1.3	6.2	0.7	-0.5	-2.5	1.0	1.0	-0.4
Commuting to job workplace: Public transport	0.6	0.7	3.6	0.3	0.3	-1.9	0.3	0.3	1.0
Fractured/broken bones in last 5 years	0.6	0.8	2.5	0.6	0.1	-1.6	1.1	0.4	1.1
Age started oral contraceptive pill	0.6	0.7	3.9	-0.4	0.6	-2.0	-0.2	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	0.5	1.4	2.2	1.4	1.5	1.2	-0.2	1.4	1.5
Schizophrenia (2014)	0.5	1.0	3.8	-1.5	-0.8	-0.2	0.7	-1.9	-0.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.9	0.2	0.6	1.7	0.8	0.5	-0.2
Blood Platelet Count	0.5	5.9	12.4	-3.5	-2.2	-3.3	0.9	-3.1	-1.7
Hearing difficulty/problems: Yes	0.5	0.8	2.7	-0.8	-0.4	-1.6	1.2	-0.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.8	1.1	0.7	-0.6	0.1	0.6	1.3
Medication: Metformin	0.5	0.7	1.8	1.0	-0.1	-0.8	-0.6	1.0	1.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.2	0.7	0.1	1.1	-1.1	0.5	-0.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.9	0.0	-1.4	-1.2	-0.1	0.1	-0.3
Hearing difficulty/problems with background noise	0.5	0.9	4.8	-0.6	0.1	-0.2	2.2	-0.4	0.8
Illnesses of siblings	0.5	0.7	2.2	0.4	0.6	0.9	-1.1	0.4	1.5
Arm fat percentage (right)	0.5	1.8	4.8	-2.2	0.8	-1.5	-0.1	-2.1	-0.9
Trunk fat-free mass	0.5	2.8	7.1	2.7	0.9	1.1	1.2	2.5	1.7
Trunk predicted mass	0.5	2.9	7.0	2.6	1.0	1.1	1.1	2.5	1.8
Birth weight of first child	0.5	0.9	2.7	0.1	0.8	0.4	1.7	0.3	1.6
Medication: Paracetamol	0.5	0.9	2.8	-1.7	-0.2	-0.7	0.2	-1.5	0.8
Body fat percentage	0.5	2.1	4.5	-2.1	-0.2	-1.6	-0.4	-2.1	-1.7
Pulse wave peak to peak time	0.5	0.5	2.8	0.5	1.7	0.1	-0.7	0.2	0.4
Health satisfaction	0.5	0.6	1.9	0.5	0.7	-1.4	1.2	-0.0	0.2
Shortness of breath walking on level ground	0.5	0.6	1.8	-0.3	1.1	-1.3	0.5	-0.5	0.9
Medication for pain relief, constipation, heartburn	0.5	0.9	2.9	1.7	0.6	0.6	-0.2	1.5	-0.4
Neck or shoulder pain in last month	0.5	0.7	2.8	-0.4	0.6	-1.7	-0.2	-0.9	0.7
Age at last live birth	0.5	0.7	1.8	-1.1	-1.0	1.4	0.0	-0.8	-0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.6	0.1	1.1	0.5	1.2	0.0	1.0
Knee pain experienced in last month	0.5	0.7	2.4	-0.3	1.6	-1.0	-0.1	-0.4	1.1
Arm fat percentage (left)	0.5	1.9	4.8	-2.2	0.6	-1.3	-0.4	-2.1	-1.2
Medication: Aspirin	0.5	0.7	1.6	-0.5	-1.0	-0.9	-1.1	-0.2	-1.3
Wears glasses or contact lenses	0.5	0.6	1.0	-1.0	0.4	-0.7	0.9	-1.0	0.7
Alcohol drinker status: Previous	0.5	0.6	1.3	-1.1	0.4	-0.5	0.3	-1.2	1.1
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	0.1	1.6	-0.6	-0.9	0.6	1.6
Depression (Nagel 2018)	0.4	0.6	2.2	-1.5	-0.0	-0.5	-0.3	-1.2	0.5
Coronary Artery Disease (CAD)	0.4	0.4	1.3	0.8	0.5	0.7	0.7	1.1	-0.1
Mean Putamen Volume	0.4	0.5	1.0	-1.0	-0.4	-0.8	0.0	-0.9	1.0
Blood White Count	0.4	2.7	7.2	-2.7	-1.3	0.2	-1.2	-2.4	-1.6
BMI	0.4	2.3	5.8	-2.1	0.3	-1.3	-1.0	-2.4	-1.6
Systolic Blood Pressure	0.4	2.2	6.3	-2.0	-0.6	-0.3	-0.6	-2.5	-2.1
Allergy or Eczema	0.4	1.1	3.3	1.0	1.4	0.1	1.3	1.8	0.0
Hand grip strength (left)	0.4	1.0	2.3	1.5	-0.9	0.7	-0.8	1.3	-1.0
Vitamin and mineral supplements	0.4	0.5	0.7	0.8	-0.7	0.8	-0.8	0.5	-0.8
Diabetes (father)	0.4	0.5	1.9	0.7	0.3	1.4	-0.1	0.9	-0.1
Pack years adult smoking proportion	0.4	0.5	1.5	0.4	0.1	-1.2	-0.6	0.6	1.2
Trunk fat percentage	0.4	1.5	2.8	-1.7	-0.1	-1.7	-0.3	-1.7	-1.5
Medication: Atenolol	0.4	0.5	1.5	-0.3	1.0	-1.2	0.5	-0.3	0.6
Sitting height	0.4	2.7	8.2	2.9	0.5	1.0	1.0	2.8	0.8
Waist circumference	0.4	1.3	4.3	-2.1	-0.2	-0.4	-0.1	-1.8	-1.2
Number of incorrect matches in round	0.4	0.6	1.8	-1.0	-1.2	0.1	0.1	-1.3	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.9	0.3	1.4	-0.5	-0.9	-0.1	-0.0
Fluid intelligence score	0.4	0.9	2.7	1.7	0.6	0.4	-0.1	1.4	1.0
Neuroticism score	0.4	0.7	4.4	-0.2	0.1	0.1	-0.8	0.1	2.1
Time employed in main current job	0.4	0.4	1.6	-0.6	-1.3	0.3	-0.0	-1.1	0.0
Father’s age at death	0.4	0.5	1.7	0.2	-0.7	-0.9	-1.3	0.3	-0.9
Pulse wave Arterial Stiffness index	0.4	0.5	2.8	-0.3	-1.7	-0.0	0.8	-0.1	-0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.8	1.4	0.7	0.3	-0.1	0.7	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.9	0.9	0.1	-1.0	1.4	0.8	1.1
Arm fat-free mass (right)	0.4	1.8	5.1	2.2	0.7	1.2	0.6	2.0	1.1
Number of children fathered	0.4	0.4	1.5	-0.2	-0.6	-1.2	-0.5	-0.4	-0.7
Medication: Allopurinol	0.4	0.5	1.8	-1.4	-0.6	-0.5	-0.3	-1.0	0.1
Chest pain or discomfort	0.4	0.6	2.3	-0.1	-0.3	-1.5	0.7	0.0	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	2.0	-0.6	-1.4	0.1	-0.2	-0.6	-0.6
Smoking status: Previous	0.4	0.6	1.4	1.0	-0.7	-0.4	-1.2	0.7	-0.9
Whole body fat-free mass	0.4	2.5	5.7	2.4	1.1	0.9	1.2	2.3	1.6
Leg fat-free mass (right)	0.4	2.2	4.0	2.0	1.3	0.8	1.6	1.9	1.8
Friendships satisfaction	0.4	0.5	1.5	0.1	1.2	-0.7	0.7	-0.0	1.2
Smoking status: Current	0.4	0.6	1.5	-0.5	-1.1	-0.5	-1.2	-0.1	-1.2
Whole body water mass	0.4	2.4	5.5	2.4	1.1	0.8	1.2	2.2	1.6
Leg predicted mass (right)	0.4	2.1	3.8	1.9	1.1	0.7	1.6	1.8	1.7
Medication: Paracetamol	0.4	0.7	2.4	-1.5	-0.1	-0.7	0.2	-1.2	0.5
Medication: Lisinopril	0.4	0.5	1.4	-0.7	0.3	-0.8	-1.2	-0.9	-0.6
Irritability	0.4	0.6	2.2	0.4	0.2	1.0	-0.7	0.7	1.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.5	-0.3	-0.1	0.7	0.2	-0.2	1.6
Pain experienced in last month	0.4	0.7	2.8	0.2	-1.3	-0.3	0.5	0.4	-1.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.1	-1.1	-0.8	0.7	0.0	-1.0	-0.7
Neuroticism (Nagel 2018)	0.3	0.7	2.7	0.2	0.4	-0.8	-1.1	0.5	1.6
Ovarian Cancer	0.3	0.4	1.0	-0.5	0.6	0.6	-0.5	-0.6	-1.0
Crohns Disease (2012)	0.3	0.5	1.9	-0.3	-1.0	0.3	-0.5	-0.6	-1.4
Primary Biliary Cirrhosis	0.3	0.4	1.4	-1.0	0.0	-0.0	-0.8	-1.2	0.0
Respiratory disease	0.3	0.8	3.8	0.3	-0.7	-1.9	-0.4	0.3	-0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	2.9	0.3	0.2	-0.6	-0.4	0.1	1.7
Neuroticism	0.3	0.7	3.7	-0.1	0.6	-0.1	-1.0	0.1	1.9
Angina	0.3	0.4	1.1	-0.1	-0.7	-0.9	0.7	0.3	1.1
Impedance of leg (right)	0.3	1.3	3.2	0.6	-1.8	0.0	-1.3	0.5	-1.8
Leg fat-free mass (left)	0.3	1.6	3.0	1.7	1.3	0.5	1.2	1.7	1.4
Current tobacco smoking	0.3	0.4	1.1	-0.4	-1.0	-0.1	-0.9	-0.1	-0.9
Taking other prescription medications	0.3	0.5	1.1	0.6	1.0	-0.7	0.1	1.1	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.3	0.1	1.2	-0.2	1.5	0.8	-0.0
Body mass index (BMI)	0.3	1.4	3.8	-1.9	0.4	-1.1	-0.5	-1.9	-1.0
Leg predicted mass (left)	0.3	1.6	3.1	1.8	1.3	0.4	1.1	1.7	1.4
Had other major operations	0.3	0.4	2.4	-0.1	-0.1	-0.2	-0.3	-0.0	-1.6
Alcohol intake versus 10 years previously	0.3	0.5	1.1	-0.8	1.0	-0.9	0.7	-0.7	-0.3
Worrier / anxious feelings	0.3	0.6	2.3	0.3	0.4	-1.0	-0.7	0.4	1.5
Prospective memory result	0.3	0.4	1.0	-0.7	0.5	-0.9	-1.0	-0.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.5	1.0	0.2	0.6	-0.1	1.2	0.9
Hair/balding pattern: Pattern 4	0.3	0.8	1.9	-1.4	-1.1	-0.8	-0.6	-1.0	-0.7
Age at first live birth	0.3	0.6	3.2	-0.2	-0.6	1.8	0.3	0.3	0.3
Medication: Blood pressure	0.3	0.6	2.9	-0.0	-1.7	-1.0	-0.4	-0.1	-0.0
Angina (self-reported)	0.3	0.4	1.0	-0.0	-0.6	-1.0	0.8	0.4	1.0
Medication: Omeprazole	0.3	0.4	2.4	-0.2	0.3	0.4	0.2	-0.3	1.5
Arm predicted mass (right)	0.3	1.4	4.2	2.0	0.4	1.0	0.6	1.9	0.9
Comparative height size at age 10	0.3	1.9	8.4	1.0	-0.7	0.1	2.9	0.9	1.6
Overall health rating	0.3	0.6	2.6	-0.2	1.1	0.1	0.0	-0.3	1.6
Illnesses of father: Heart disease	0.3	0.5	1.1	0.9	1.1	-0.2	0.0	0.6	-1.0
Ever had bowel cancer screening	0.3	0.4	1.1	-1.1	0.1	-1.0	-0.2	-0.7	-0.5
Mineral and other dietary supplements	0.3	0.4	1.2	0.8	0.1	1.1	-0.2	0.5	-0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	1.2	-1.1	-0.3	-0.2	-0.3	-0.5	0.9
Illnesses of father: High blood pressure	0.3	0.3	1.4	0.4	-1.2	-0.3	0.4	0.2	-0.7
Basal metabolic rate	0.3	1.8	4.2	2.0	1.1	0.8	1.1	1.9	1.4
Arm fat-free mass (left)	0.3	1.4	3.4	1.9	0.7	0.7	0.8	1.7	1.2
Unable to work because of sickness or disability	0.3	0.4	1.0	-0.4	0.8	-1.0	0.8	-0.3	-0.0
Pack years of smoking	0.3	0.4	1.5	0.1	-0.1	-1.0	-0.6	0.2	1.2
Bipolar Disorder or Schizophrenia	0.2	0.5	2.6	0.0	-0.1	0.7	1.6	-0.3	0.5
Worry (Nagel 2018)	0.2	0.4	0.9	0.6	-0.6	-0.4	-0.8	0.6	0.9
Crohns Disease (2017)	0.2	0.4	0.9	-0.4	-0.5	-0.5	-1.0	-0.3	-1.0
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	0.4	1.0	-0.7	0.4	0.1	-1.1
Major Depression (MDD)	0.2	0.2	0.8	-0.7	-0.3	-0.0	0.9	-0.3	0.2
Prostate Cancer	0.2	0.3	0.6	0.6	0.7	0.6	0.2	0.5	0.5
Rheumatoid Arthritis	0.2	0.3	0.9	-0.8	-0.2	-0.2	0.2	-1.0	0.8
Blood Eosinophil Count	0.2	1.9	5.3	1.7	1.1	-0.1	-2.3	1.8	-0.9
Cardiovascular Disease	0.2	0.7	3.1	-0.6	-1.8	0.7	-0.7	-0.5	-0.5
Lung FVC	0.2	1.2	3.1	-1.2	0.9	0.6	1.2	-1.1	1.8
Sensitivity / hurt feelings	0.2	0.3	0.7	-0.1	0.7	-0.9	-0.3	0.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.7	0.3	0.2	-0.8	-0.4	0.8
Medication: Levothyroxine sodium	0.2	0.4	1.0	0.9	-0.2	-1.0	0.5	0.7	0.6
Impedance of leg (left)	0.2	1.0	3.6	0.5	-1.9	0.2	-0.7	0.4	-1.5
Financial difficulties in last 2 years	0.2	0.3	1.4	0.1	0.4	1.2	-0.3	0.1	0.4
Mouth/teeth dental problems	0.2	0.3	1.2	-0.0	-0.0	1.1	0.7	0.0	-0.3
Heart attack	0.2	0.3	0.9	-0.0	-0.0	0.6	-1.0	0.2	0.6
Medication: Ramipril	0.2	0.3	0.9	-0.3	-0.4	-1.0	0.3	-0.5	0.7
Medication: Simvastatin	0.2	0.3	0.8	0.4	-0.4	0.9	0.5	0.3	0.9
Noisy workplace	0.2	0.3	1.0	-0.1	-0.1	0.7	-0.5	0.3	1.0
Breastfed as a baby	0.2	0.2	0.6	0.1	-0.0	-0.4	0.8	0.2	0.8
Tense / ‘highly strung’	0.2	0.3	0.7	-0.7	-0.8	0.1	0.4	-0.7	0.6
Pulse wave reflection index	0.2	0.2	0.7	0.8	-0.0	0.6	-0.0	0.7	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.8	0.6	-0.3	1.3	-0.6	0.4	0.0
Gout (self-reported)	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.6	-0.3	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.7	0.9	0.1	-0.1	0.8	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.7	0.5	0.7	-0.8	0.4	0.5	0.3
Whole body fat mass	0.2	0.7	1.4	-1.2	0.2	-1.0	0.1	-1.1	-1.0
Leg fat mass (right)	0.2	0.7	2.0	-1.4	0.2	-1.1	-0.1	-1.2	-0.7
Pulse rate, automated reading	0.2	0.7	1.8	-1.4	-0.3	-0.9	-0.9	-1.0	-0.6
Suffer from ‘nerves’	0.2	0.3	1.3	0.3	-0.4	-0.1	-1.1	0.1	0.5
Hypertension (Self-reported)	0.2	0.5	1.9	-0.6	-1.4	-0.1	-0.6	-0.7	-0.4
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.3	-0.8	-0.1	0.4	-0.7	0.1
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.3	0.3	-0.4	0.6	-0.7	0.4
Number of self-reported non-cancer illnesses	0.2	0.4	2.1	-0.5	-1.4	-0.5	-0.2	-0.3	0.1
Miserableness	0.2	0.4	0.9	0.2	0.5	-0.9	-0.6	0.4	0.9
High cholesterol (Self-reported)	0.2	0.3	1.9	-0.3	-1.4	0.1	-0.3	-0.4	0.2
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.6	-0.5	0.6	-0.3	-0.1	-0.5	-0.8
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.9	0.6	1.4	0.7	0.9	0.8	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.1	-0.1	-0.1	0.7	-1.0	0.1	0.7
Leg fat mass (left)	0.2	0.7	2.0	-1.4	0.1	-0.9	-0.1	-1.2	-0.8
Arm predicted mass (left)	0.2	1.2	3.5	1.9	0.7	0.5	0.6	1.7	0.9
Hypothyroidism (self reported)	0.1	0.3	0.6	0.6	-0.3	-0.7	0.2	0.6	0.8
Number of treatments/medications taken	0.1	0.2	1.3	-0.3	-0.1	-1.2	-0.2	-0.1	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	0.3	-0.4	-0.6	0.3	0.3	-0.5
High blood pressure	0.1	0.4	1.6	-0.5	-1.3	-0.1	-0.7	-0.6	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.7	0.3	0.0	-0.8	0.4	0.2	0.3
Trunk fat mass	0.1	0.5	1.6	-0.8	0.1	-1.3	0.1	-0.8	-0.8
Impedance of arm (right)	0.1	0.4	1.2	0.9	0.5	-0.4	0.7	1.1	-0.2
Number of live births	0.1	0.2	0.8	0.1	-0.2	-0.7	-0.1	0.2	-0.9
Arm fat mass (right)	0.1	0.6	1.3	-1.1	0.9	-0.9	0.1	-1.0	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	-0.1	0.2	0.1	-0.3	-0.3
Medication: Amlodipine	0.1	0.1	0.5	0.4	0.1	0.7	0.2	0.1	0.3
Birth weight	0.1	0.3	0.8	-0.1	-0.3	0.9	-0.8	-0.4	0.1
Number of full brothers	0.1	0.2	0.7	0.1	0.4	-0.9	0.3	0.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	0.1	0.2	0.6	-0.5	0.4	0.2
Number of full sisters	0.1	0.1	0.5	0.4	0.7	-0.3	0.1	0.1	-0.1
Osteoarthritis (self-reported)	0.1	0.1	0.6	-0.2	0.1	0.7	-0.2	-0.3	0.3
Arm fat mass (left)	0.1	0.6	1.1	-1.1	0.8	-0.9	-0.1	-1.1	-0.7
Medication: Blood pressure	0.1	0.2	1.0	-0.2	1.0	0.7	-0.1	-0.3	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.5	0.1	-0.5	-0.4	-0.7	-0.3
Ever depressed for a whole week	0.1	0.2	0.5	-0.1	-0.3	0.7	-0.6	-0.2	0.3
Cholesterol lowering medication	0.1	0.1	0.4	0.0	-0.2	0.6	0.2	0.0	0.7
Supplements: Calcium	0.1	0.2	0.6	0.3	0.4	0.5	0.8	0.3	0.1
Impedance of whole body	0.1	0.5	1.4	0.7	-1.0	-0.1	-0.5	0.6	-1.2
Reaction Time	0.0	0.1	0.1	0.3	-0.3	0.3	0.3	-0.1	0.3
Hair Pigment	0.0	0.3	0.8	0.9	0.7	-0.7	0.2	0.5	0.3
Tanning	0.0	0.4	1.3	-0.5	-0.2	-1.1	-0.7	-0.8	-0.0
Weight	0.0	0.2	0.5	0.5	0.7	-0.4	0.7	0.5	0.2
Hip circumference	0.0	0.1	0.5	-0.5	0.7	-0.1	0.1	-0.1	-0.4
Pulse rate	0.0	0.1	0.3	-0.1	0.6	-0.2	0.1	0.1	0.2
Impedance of arm (left)	0.0	0.2	0.4	0.6	0.1	-0.4	0.1	0.6	-0.5

Hub : Genes

MED13

Models

Trait associations