TWAS hub - MED27

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Whole Blood	0.1210	0.0370	7.9e-05	0.050	NA	0.035	NA	0.041	2.2e-05	NA	3.4e-04	NA	1.1e-04
2	YFS	Blood	0.0544	0.0127	4.4e-12	0.061	0.047	0.063	0.059	0.062	3.8e-19	4.7e-15	1.0e-19	1.1e-18	1.3e-19

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Frequency of depressed mood in last 2 weeks	10.0	14.0	15.1	3.6	3.9
Depression (Nagel 2018)	9.5	14.3	14.5	3.8	3.7
Age started oral contraceptive pill	9.0	11.3	11.7	-3.3	-3.4
Length of working week for main job	8.9	9.8	11.2	3.3	2.9
Depressed Affect (Nagel 2018)	8.0	16.7	17.2	4.0	4.2
Alcohol usually taken with meals	7.9	12.8	13.0	-3.6	-3.5
Breastfed as a baby	7.9	9.9	10.2	-3.1	-3.2
Leg fat percentage (right)	7.9	28.7	29.1	5.3	5.4
Frequency of tenseness / restlessness in last 2 weeks	7.8	12.1	13.2	3.3	3.6
Type 2 Diabetes (T2D) (2012)	7.3	8.5	9.6	2.7	3.1
Neuroticism (Nagel 2018)	7.0	16.4	17.0	4.0	4.1
Supplements: Zinc	7.0	7.6	8.0	2.7	2.8
Fed-up feelings	7.0	12.7	13.8	3.4	3.7
Medication: Aspirin	7.0	9.1	9.2	3.0	3.0
Intelligence (Savage-Jansen 2018)	6.9	21.3	21.7	-4.7	-4.6
Fluid intelligence score	6.8	14.1	14.4	-3.7	-3.8
Prospective memory result	6.8	8.4	8.9	2.8	3.0
Qualifications: None of the above	6.6	14.2	15.7	3.6	4.0
Leg fat mass (right)	6.6	25.7	26.0	5.0	5.1
Leg fat percentage (left)	6.6	24.1	24.3	4.9	4.9
Neuroticism (2016)	6.5	9.3	9.4	3.0	3.1
Father’s age at death	6.4	8.6	8.9	-2.9	-3.0
Loneliness, isolation	6.4	8.9	9.5	2.9	3.1
Qualifications: College or University degree	6.3	19.8	20.7	-4.5	-4.3
Smoking Status	6.2	14.9	17.6	4.2	3.5
Body mass index (BMI)	6.2	26.3	26.6	5.1	5.2
Qualifications: A levels/AS levels or equivalent	6.2	13.8	14.2	-3.8	-3.7
Leg fat mass (left)	6.2	24.2	24.5	4.9	5.0
Medication: Co-codamol	6.1	7.0	7.4	2.7	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.1	7.2	8.2	2.5	2.9
Cholesterol lowering medication	6.0	8.8	9.5	3.1	2.9
Maternal smoking around birth	5.9	8.6	8.7	2.9	3.0
Waist circumference	5.9	21.6	22.3	4.6	4.7
Medication: Aspirin	5.8	7.6	7.7	2.8	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	5.6	7.5	8.0	2.6	2.8
Pack years adult smoking proportion	5.5	8.4	8.9	2.8	3.0
Qualifications: nursing, teaching	5.5	8.5	9.0	-3.0	-2.8
BMI	5.3	30.8	31.4	5.5	5.6
Smoking status: Current	5.3	8.3	8.7	3.0	2.8
Current tobacco smoking	5.2	8.5	9.1	3.0	2.8
Pain all over the body in last month	5.0	5.4	5.5	2.4	2.3
Serious illness, injury or assault of a close relative in last 2 years	5.0	5.8	6.6	-2.2	-2.6
Depression (self-reported)	5.0	6.0	6.2	2.4	2.5
Neuroticism	4.9	11.7	12.5	3.3	3.5
Diabetes (self-reported)	4.9	7.6	7.8	2.8	2.7
Medication: Simvastatin	4.8	7.1	7.8	2.5	2.8
Mood swings	4.8	8.7	9.1	2.9	3.0
Noisy workplace	4.7	5.7	6.1	2.3	2.5
Overall health rating	4.7	10.1	11.0	3.0	3.3
Pack years of smoking	4.7	7.0	7.5	2.5	2.7
Shortness of breath walking on level ground	4.5	5.3	5.4	2.3	2.3
Alzheimer’s Disease (in father)	4.4	4.8	5.1	-2.2	-2.1
Arm fat mass (right)	4.4	18.3	19.0	4.2	4.4
Chronic bronchitis/emphysema (mother)	4.4	5.2	5.4	2.2	2.3
Diabetes (mother)	4.2	5.3	5.8	2.4	2.2
Impedance of arm (left)	4.2	19.6	21.1	-4.6	-4.3
Arm fat mass (left)	4.2	17.4	18.0	4.1	4.2
Bilateral oophorectomy (both ovaries removed)	4.1	4.7	5.2	2.1	2.3
Whole body fat mass	4.1	17.2	17.7	4.1	4.2
Verbal and Numeric Reasoning (VNR)	3.9	9.3	9.6	-3.0	-3.1
Medication: Paracetamol	3.8	6.3	6.8	2.6	2.4
Body fat percentage	3.8	14.9	15.6	3.8	4.0
Ever highly irritable/argumentative for 2 days	3.7	4.5	4.8	2.0	2.2
Suffer from ‘nerves’	3.7	5.8	5.9	2.4	2.4
Weight	3.6	17.6	18.0	4.2	4.2
Impedance of arm (right)	3.6	16.9	18.6	-4.3	-3.9
Age at last live birth	3.6	5.2	5.7	-2.2	-2.4
Arm predicted mass (left)	3.6	18.2	18.7	4.3	4.2
Mother’s age at death	3.5	4.4	5.0	-2.0	-2.2
Medication: Paracetamol	3.5	5.4	6.0	2.4	2.2
Lupus	3.4	5.1	5.6	2.2	2.4
Type 2 Diabetes (T2D) (2018)	3.4	6.5	7.3	2.7	2.4
Serious illness, injury or assault to yourself	3.4	4.1	4.7	1.9	2.2
Multivitamins +/- minerals	3.4	4.4	5.1	2.3	1.9
Neuroticism score	3.4	7.0	7.6	2.5	2.8
Arm fat percentage (right)	3.4	13.3	14.0	3.5	3.7
Falls in the last year	3.4	4.6	5.9	2.4	1.8
Medication for pain relief, constipation, heartburn	3.4	5.8	6.6	-2.6	-2.2
Arm fat percentage (left)	3.4	13.4	13.9	3.6	3.7
Diabetes diagnosed by doctor	3.4	5.6	5.9	2.4	2.3
Arm fat-free mass (left)	3.4	17.1	17.4	4.2	4.1
Trunk fat mass	3.3	14.0	14.7	3.6	3.8
Handedness (chirality/laterality): Left-handed	3.3	4.0	4.3	-1.9	-2.1
Arm predicted mass (right)	3.2	16.4	17.1	4.1	4.0
Tense / ‘highly strung’	3.1	5.2	5.3	2.2	2.3
Long-standing illness, disability or infirmity	3.1	4.7	4.8	2.2	2.2
Number of self-reported non-cancer illnesses	3.1	5.5	6.2	2.5	2.2
Unable to work because of sickness or disability	3.1	4.0	4.2	1.9	2.0
Heart disease (siblings)	3.1	3.7	4.8	1.6	2.2
Pulse wave Arterial Stiffness index	3.0	3.5	3.7	1.9	1.8
Chronic bronchitis/emphysema (father)	2.9	3.3	3.9	2.0	1.7
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	4.4	-1.8	-2.1
Arm fat-free mass (right)	2.9	14.7	15.4	3.9	3.7
Chest pain or discomfort	2.9	4.1	4.4	2.1	2.0
Pulse wave peak to peak time	2.8	3.3	3.5	-1.9	-1.8
Average weekly red wine intake	2.8	4.2	4.4	-2.1	-2.0
Osteoporosis (self-reported)	2.8	3.4	3.6	1.9	1.8
Deep venous thrombosis (DVT) (self-reported)	2.8	3.6	3.6	-1.9	-1.9
Worry (Nagel 2018)	2.7	5.8	6.3	2.3	2.5
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	3.6	1.9	1.5
Wheeze or whistling in the chest in last year	2.7	4.8	4.8	2.2	2.2
Emphysema/chronic bronchitis	2.7	3.1	3.4	1.8	1.7
Body Mass Index (BMI) (2010)	2.6	3.6	4.1	2.0	1.7
Waist Hip Ratio (WHR)	2.6	11.6	12.6	3.3	3.5
Age at first live birth	2.6	4.6	4.6	-2.2	-2.1
Fractured/broken bones in last 5 years	2.6	3.4	3.7	-1.7	-1.9
Illnesses of siblings	2.5	3.4	4.2	-1.6	-2.1
Basal metabolic rate	2.5	13.7	13.8	3.7	3.7
Impedance of whole body	2.5	12.6	13.5	-3.7	-3.4
Number of treatments/medications taken	2.4	4.4	4.7	2.2	2.0
Ever unenthusiastic/disinterested for a whole week	2.4	2.9	3.1	1.8	1.6
Financial difficulties in last 2 years	2.4	3.2	3.7	1.9	1.7
Medication: Lansoprazole	2.4	2.7	3.0	1.7	1.6
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.8	4.0	1.9	2.0
Sensitivity / hurt feelings	2.2	3.7	3.9	2.0	1.9
Trunk fat percentage	2.2	8.8	9.5	2.9	3.1
Miserableness	2.2	3.7	3.8	1.9	1.9
Pain experienced in last month	2.2	3.7	4.0	-2.0	-1.8
Heart attack	2.1	2.7	3.1	1.8	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.3	3.3	1.8	1.8
Blood clot in the leg (DVT)	2.1	2.7	2.8	-1.7	-1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	3.4	1.8	1.2
Osteoarthritis (self-reported)	2.1	2.7	2.9	1.7	1.6
Irritability	2.1	3.6	4.0	2.0	1.8
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	3.2	1.8	1.3
Whole body fat-free mass	2.0	11.3	11.7	3.4	3.3
Ever taken oral contraceptive pill	2.0	2.2	2.4	1.6	1.4
Trunk predicted mass	1.9	10.7	11.3	3.4	3.2
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	2.6	-1.5	-1.6
Health satisfaction	1.9	2.5	2.7	1.5	1.7
Medication: Omeprazole	1.9	2.3	3.0	1.7	1.3
Whole body water mass	1.9	10.8	11.2	3.3	3.2
Rheumatoid Arthritis	1.8	2.4	2.6	1.5	1.6
Trunk fat-free mass	1.8	10.2	10.8	3.3	3.1
Migraine (self-reported)	1.8	2.2	2.3	-1.5	-1.4
Financial situation satisfaction	1.8	2.2	2.5	1.4	1.6
Illnesses of father: High blood pressure	1.8	2.2	2.3	1.5	1.5
Heart attack/myocardial infarction (self-reported)	1.8	2.4	2.8	1.7	1.4
Allergy or Eczema	1.7	4.6	4.8	-2.2	-2.1
Average weekly spirits intake	1.7	2.1	2.5	1.6	1.3
Leg fat-free mass (left)	1.7	8.8	8.9	3.0	3.0
Leg predicted mass (left)	1.7	9.2	9.3	3.0	3.1
Tinnitus: Yes, now most or all of the time	1.7	1.9	2.2	-1.3	-1.5
Angina	1.6	2.1	2.1	1.5	1.4
Medication for hormone replacement therapy	1.6	1.8	1.9	1.4	1.3
Qualifications: CSEs or equivalent	1.6	2.1	2.3	1.5	1.4
Hayfever, allergic rhinitis or eczema	1.6	3.5	3.8	-1.9	-1.8
Back pain experienced in last month	1.6	2.4	2.7	1.6	1.4
Major Depression (MDD)	1.5	1.8	1.9	1.3	1.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	2.7	-1.5	-1.6
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	3.1	-1.3	-1.8
Number of full sisters	1.5	1.8	1.9	1.4	1.3
Hearing difficulty/problems with background noise	1.4	2.2	2.8	-1.7	-1.3
Time employed in main current job	1.4	1.6	2.0	1.4	1.1
High blood pressure (siblings)	1.4	2.0	2.6	1.2	1.6
Supplements: Calcium	1.4	1.6	1.7	1.2	1.3
Alzheimer’s Disease (including proxy)	1.3	1.9	2.3	-1.5	-1.2
Worrier / anxious feelings	1.3	2.4	2.7	1.4	1.7
Hair/balding pattern: Pattern 3	1.3	1.9	2.4	-1.2	-1.6
Medication: Cholesterol lowering	1.3	2.0	2.5	1.3	1.6
Exposure to tobacco smoke at home	1.3	1.5	1.7	1.3	1.1
Illnesses of siblings: Diabetes	1.3	1.6	1.9	1.1	1.4
Vitamin and mineral supplements	1.2	1.6	2.0	-1.4	-1.1
Hand grip strength (right)	1.2	3.2	3.6	1.9	1.7
Hip circumference	1.2	5.2	5.4	2.3	2.3
Angina (self-reported)	1.2	1.5	1.6	1.3	1.2
Medication: Allopurinol	1.2	1.6	2.0	-1.1	-1.4
Eye problems/disorders: Cataract	1.2	1.3	1.4	-1.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	2.9	-1.5	-1.7
Guilty feelings	1.2	1.8	2.0	1.3	1.4
Hearing aid user	1.2	1.4	1.5	-1.1	-1.2
High cholesterol (Self-reported)	1.2	2.2	2.7	1.3	1.6
Gout (self-reported)	1.1	1.5	1.9	-1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	2.3	1.5	1.5
Leg fat-free mass (right)	1.1	5.7	5.7	2.4	2.4
Friendships satisfaction	1.1	1.3	1.7	1.0	1.3
Commuting to job workplace: Walk	1.1	1.2	1.6	-1.3	-0.9
Leg predicted mass (right)	1.1	5.7	5.8	2.4	2.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	1.6	-1.1	-1.3
Vascular/heart problems diagnosed by doctor	1.1	2.9	3.0	-1.7	-1.7
Ever had hysterectomy (womb removed)	1.0	1.1	1.1	1.0	1.1
Illnesses of father: None of the above (group 1)	1.0	1.2	1.4	-1.2	-1.0
Diastolic blood pressure, automated reading	1.0	3.2	3.3	1.8	1.8
Past tobacco smoking	0.9	1.7	2.3	-1.5	-1.0
Nervous feelings	0.9	1.6	1.9	1.1	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	1.4	1.2	1.0
Number of children fathered	0.9	1.0	1.1	1.0	1.0
Medication: Blood pressure	0.9	1.6	1.9	1.1	1.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	1.6	1.3	0.7
Crohns Disease (2017)	0.8	1.7	2.2	1.5	1.1
Bipolar Disorder (2011)	0.8	0.8	1.0	1.0	0.8
Coronary Artery Disease (CAD)	0.8	0.9	1.4	1.2	0.6
Fasting Glucose	0.8	1.0	1.1	0.9	1.1
Triglycerides	0.8	1.3	1.4	1.2	1.0
Blood Eosinophil Count	0.8	6.0	6.2	2.5	2.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.1	1.1	1.0
Medication: Metformin	0.8	1.1	1.2	1.1	1.0
High blood pressure	0.8	2.2	2.5	1.4	1.6
Irritable Bowel Disease (IBD)	0.7	1.6	1.9	1.4	1.2
Chronotype (morning person)	0.7	1.6	1.6	1.2	1.3
Townsend deprivation index at recruitment	0.7	0.9	1.0	0.9	1.0
Taking other prescription medications	0.7	1.1	1.3	1.1	1.0
Age at First Birth	0.6	0.9	1.3	-1.1	-0.7
Blood Platelet Count	0.6	7.2	7.6	2.8	2.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.0	1.0	0.8
Stomach or abdominal pain in last month	0.6	0.8	0.9	1.0	0.8
Mouth/teeth dental problems	0.6	1.0	1.1	1.0	1.0
Alcohol intake frequency.	0.6	1.3	1.3	1.2	1.1
Blood White Count	0.5	3.5	3.8	1.9	1.8
Cardiovascular Disease	0.5	1.6	2.1	1.0	1.5
Respiratory disease	0.5	1.1	1.3	1.1	1.0
Lung FEV1/FVC ratio	0.5	2.4	3.0	-1.7	-1.4
Hand grip strength (left)	0.5	1.4	1.5	1.2	1.1
Severe depression (siblings)	0.5	0.5	0.6	0.7	0.8
Mouth/teeth dental problems: Dentures	0.5	0.8	0.9	0.9	0.9
Forced vital capacity (FVC), Best measure	0.5	1.7	2.0	-1.2	-1.4
Family relationship satisfaction	0.5	0.7	0.7	-0.9	-0.8
Hypertension (Self-reported)	0.5	1.3	1.5	1.1	1.2
Commuting to job workplace: Public transport	0.5	0.6	0.7	-0.8	-0.8
Alcohol drinker status: Never	0.5	0.6	0.8	0.9	0.6
Commuting to job workplace: Cycle	0.5	0.6	0.8	-0.9	-0.7
Ulcerative Colitis (UC)	0.4	0.7	0.7	0.8	0.8
Crohns Disease (2012)	0.4	0.7	1.0	1.0	0.6
Primary Biliary Cirrhosis	0.4	0.5	0.6	-0.8	-0.6
Lung FVC	0.4	1.9	2.6	-1.1	-1.6
Hearing difficulty/problems: Yes	0.4	0.6	0.8	-0.9	-0.6
Supplements: Glucosamine	0.4	0.5	0.7	-0.5	-0.8
Impedance of leg (left)	0.4	1.8	1.9	-1.4	-1.3
Allergy	0.4	0.9	0.9	1.0	1.0
Asthma	0.4	0.8	1.0	1.0	0.7
Pulse wave reflection index	0.4	0.5	0.7	0.8	0.6
Headache pain in last month	0.4	0.7	0.9	0.9	0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.7	0.5	0.8
Mean time to correctly identify matches	0.4	0.7	0.8	-0.8	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.6	-0.5	-0.8
Smoking status: Previous	0.4	0.6	1.0	1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.6	0.8	0.6
Medication: Gliclazide	0.4	0.5	0.7	0.5	0.9
Ever depressed for a whole week	0.4	0.6	0.6	0.7	0.8
Myopia	0.4	0.6	0.6	-0.8	-0.8
Breast Cancer	0.3	0.8	0.8	-0.9	-0.9
Ovarian Cancer	0.3	0.4	0.5	0.5	0.7
Medication: Atenolol	0.3	0.4	0.4	0.6	0.6
Forced vital capacity (FVC)	0.3	1.1	1.3	-0.9	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.5	0.7	0.5
Lung cancer (father)	0.3	0.3	0.4	0.6	0.5
Loud music exposure frequency	0.3	0.4	0.7	0.8	0.3
Exposure to tobacco smoke outside home	0.3	0.3	0.4	0.5	0.6
Pulse rate, automated reading	0.3	0.8	1.1	-1.1	-0.7
Ever had bowel cancer screening	0.3	0.3	0.4	-0.5	-0.6
Medication for cholesterol	0.3	0.4	0.4	-0.6	-0.6
Bipolar Disorder (2018)	0.2	0.4	0.5	0.7	0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.2	-0.4	-0.5
Blood Red Count	0.2	1.6	2.1	1.4	1.1
Hypothyroidism (self reported)	0.2	0.5	0.6	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.4	0.6	0.7
Alcohol intake versus 10 years previously	0.2	0.3	0.5	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	0.8	-0.7	-0.9
Happiness	0.2	0.2	0.4	0.2	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.6	-0.7	-0.8
Standing height	0.2	2.4	2.5	-1.6	-1.5
Glaucoma (self-reported)	0.2	0.2	0.2	-0.4	-0.5
Birth weight	0.2	0.5	0.6	0.8	0.6
Medication: Seretide 50 evohaler	0.2	0.2	0.3	0.5	0.4
Heart disease (mother)	0.2	0.2	0.3	0.5	0.3
Leg pain on walking	0.2	0.2	0.3	0.6	0.4
Illnesses of father: Heart disease	0.2	0.3	0.5	0.7	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.3	-0.6	-0.6
Mineral and other dietary supplements	0.2	0.3	0.4	0.4	0.6
Asthma (self-reported)	0.2	0.4	0.5	0.7	0.5
Wears glasses or contact lenses	0.2	0.2	0.2	0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.3	0.5	0.4
Medication: Bendroflumethiazide	0.2	0.3	0.5	-0.7	-0.4
Number of operations (self-reported)	0.2	0.3	0.6	0.8	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.3	-0.2	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	0.7	0.3
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.4	-0.2
LDL Cholesterol	0.1	0.1	0.1	0.3	0.3
Schizophrenia (2014)	0.1	0.3	0.6	0.7	0.3
Heel T-Score	0.1	0.4	0.8	0.9	0.2
Height	0.1	2.4	2.7	-1.6	-1.4
Impedance of leg (right)	0.1	0.5	0.6	-0.8	-0.6
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	0.3
Medication: Levothyroxine sodium	0.1	0.1	0.1	-0.3	-0.4
Had other major operations	0.1	0.1	0.2	0.4	0.3
Number of live births	0.1	0.1	0.2	0.2	0.5
Pulse rate	0.1	0.1	0.1	-0.3	-0.3
Illnesses of mother	0.1	0.1	0.1	0.3	0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.3	0.5	0.6
Peak expiratory flow (PEF)	0.1	0.2	0.2	0.5	0.4
Medication: Amlodipine	0.1	0.2	0.3	0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.2	0.3	0.5
Medication: Ibuprofen	0.1	0.1	0.1	0.3	0.1
Had major operations	0.1	0.1	0.1	-0.3	-0.4
Supplements: Vitamin C	0.1	0.2	0.2	0.4	0.4
Medication: Lisinopril	0.1	0.1	0.2	0.2	0.4
Medication: Atorvastatin	0.1	0.1	0.2	0.4	0.2
Ever smoked	0.1	0.1	0.2	0.2	-0.4
Risk taking	0.1	0.2	0.3	0.6	-0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.1	-0.5
Schizophrenia (2018)	0.0	0.0	0.1	0.3	0.0
Reaction Time	0.0	0.0	0.0	-0.1	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.0	-0.1	0.1
HbA1C	0.0	0.1	0.1	0.3	0.1
HDL Cholesterol	0.0	0.0	0.0	-0.1	0.0
Ulcerative Colitis	0.0	0.1	0.1	-0.3	-0.2
Systolic Blood Pressure	0.0	0.1	0.1	-0.3	0.1
Hair Pigment	0.0	0.2	0.3	-0.3	-0.6
Tanning	0.0	0.3	0.4	-0.5	-0.6
Relative age of first facial hair	0.0	0.1	0.1	-0.3	-0.1
Systolic blood pressure, automated reading	0.0	0.0	0.1	0.1	0.3
Diabetes (father)	0.0	0.0	0.0	-0.2	-0.0
Relative age voice broke	0.0	0.0	0.0	0.1	-0.0
Age when periods started (menarche)	0.0	0.0	0.0	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.1	0.3
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.1	-0.3	-0.0
Sitting height	0.0	0.0	0.1	-0.3	-0.1
High blood pressure (mother)	0.0	0.1	0.1	-0.2	-0.3
Number of incorrect matches in round	0.0	0.1	0.1	0.1	0.3
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.2	0.1
Had menopause	0.0	0.0	0.1	-0.1	-0.3
Medication: Ramipril	0.0	0.0	0.0	-0.1	-0.2
Birth weight of first child	0.0	0.0	0.0	0.2	0.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Comparative body size at age 10	0.0	0.1	0.1	0.4	0.1
Number of full brothers	0.0	0.0	0.1	0.1	0.2
Worry too long after embarrassment	0.0	0.0	0.1	-0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.0	0.1	-0.0
Eye problems/disorders: None of the above	0.0	0.0	0.0	0.0	0.1
Neck or shoulder pain in last month	0.0	0.0	0.0	-0.2	-0.1
Comparative height size at age 10	0.0	0.1	0.1	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	0.1	0.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	-0.0	0.1
Knee pain experienced in last month	0.0	0.0	0.0	0.1	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.0	-0.1
Breast cancer (self-reported)	0.0	0.0	0.0	0.1	-0.2
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.2	0.2
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.2	0.1
Medication: Blood pressure	0.0	0.1	0.1	0.2	0.2
Average weekly beer plus cider intake	0.0	0.0	0.1	0.3	-0.1
Alcohol drinker status: Previous	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

MED27

Models

Trait associations