TWAS hub - MEG3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0478	0.0175	0.0013	0.009	0.021	0.017	0.022	0.022	1.5e-02	2.9e-04	1.2e-03	2.7e-04	2.4e-04
2	YFS	Blood	0.1463	0.0214	0.0000	0.141	0.125	0.151	0.144	0.154	6.6e-44	8.4e-39	4.2e-47	8.4e-45	4.6e-48

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Platelet Count	31.2	361.9	470.9	15.9	21.7
Osteoarthritis (self-reported)	11.3	14.6	17.6	-3.4	-4.2
Age when periods started (menarche)	8.5	20.4	21.3	-4.6	-4.4
Smoking status: Previous	6.6	9.8	10.2	-3.1	-3.2
Past tobacco smoking	5.8	10.7	14.6	2.6	3.8
Leg fat mass (right)	5.8	22.3	23.5	-4.8	-4.6
Leg fat mass (left)	5.8	22.5	23.8	-4.9	-4.6
Multivitamins +/- minerals	5.7	7.3	10.6	3.3	2.0
Back pain experienced in last month	5.7	8.4	10.1	-2.6	-3.2
Wears glasses or contact lenses	5.5	6.4	8.1	2.8	2.2
Waist circumference	5.4	19.8	22.0	-4.2	-4.7
Neck or shoulder pain in last month	5.3	7.5	8.1	-2.8	-2.6
Whole body fat mass	5.3	22.3	23.4	-4.8	-4.6
Medication: Co-codamol	5.2	6.0	7.0	-2.6	-2.2
Medication: Paracetamol	5.2	8.6	8.7	-2.9	-2.9
Weight	5.0	24.8	27.5	-4.7	-5.2
Hip circumference	5.0	21.6	21.6	-4.7	-4.6
Arm fat mass (right)	5.0	20.5	20.9	-4.5	-4.6
Illnesses of siblings: Diabetes	5.0	6.1	7.5	-2.2	-2.7
Arm fat mass (left)	5.0	20.4	20.5	-4.5	-4.5
Leg fat percentage (left)	5.0	18.2	24.0	-4.9	-3.5
Ovarian Cancer	4.9	6.5	10.9	-1.4	-3.3
Medication: Paracetamol	4.9	7.6	9.5	-3.1	-2.4
Diabetes (self-reported)	4.8	7.5	11.2	-1.9	-3.3
Leg fat percentage (right)	4.8	17.5	22.9	-4.8	-3.5
Trunk fat mass	4.6	19.6	21.3	-4.6	-4.2
Body fat percentage	4.4	17.2	22.7	-4.8	-3.4
Body mass index (BMI)	4.2	17.9	19.0	-4.4	-4.1
Number of incorrect matches in round	4.2	7.0	7.4	2.6	2.7
Ever smoked	4.2	7.4	12.4	-1.6	-3.5
Alzheimer’s Disease (in father)	4.0	4.3	8.6	2.9	0.2
Pain experienced in last month	3.9	6.4	6.4	2.5	2.5
Trunk fat percentage	3.8	15.2	19.1	-4.4	-3.4
Blood White Count	3.6	26.3	45.2	2.7	6.7
High blood pressure (mother)	3.6	5.0	6.9	2.6	1.8
Arm fat percentage (left)	3.6	14.5	18.4	-4.3	-3.2
Bilateral oophorectomy (both ovaries removed)	3.5	4.1	5.8	-1.5	-2.4
Arm fat percentage (right)	3.5	13.7	16.9	-4.1	-3.2
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	8.9	3.0	1.5
Medication: Amlodipine	3.5	4.9	5.6	2.0	2.4
Overall health rating	3.5	7.6	10.3	-3.2	-2.2
Long-standing illness, disability or infirmity	3.5	5.4	6.5	-2.5	-2.1
Diabetes diagnosed by doctor	3.5	5.8	8.6	-1.7	-2.9
Medication: Lisinopril	3.5	4.5	5.7	1.8	2.4
Number of operations (self-reported)	3.5	5.1	7.1	-1.8	-2.7
Type 2 Diabetes (T2D) (2018)	3.4	6.4	9.4	-1.9	-3.1
Migraine (self-reported)	3.4	4.3	5.4	1.8	2.3
Townsend deprivation index at recruitment	3.2	4.6	7.6	-1.2	-2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	3.2	4.1	4.6	-2.1	-1.9
Arm predicted mass (right)	3.2	16.1	23.7	-2.9	-4.9
Pulse rate, automated reading	3.2	10.3	13.5	-3.7	-2.6
Leg pain on walking	3.2	4.0	4.5	-2.1	-1.9
Commuting to job workplace: Public transport	3.2	3.8	5.5	2.3	1.5
Heart disease (siblings)	3.2	3.9	4.2	-1.9	-2.1
Alzheimer’s Disease (including proxy)	3.1	4.4	7.2	2.7	1.3
Arm fat-free mass (right)	3.1	15.7	23.6	-2.8	-4.9
Arm predicted mass (left)	3.1	15.5	23.6	-2.7	-4.9
Rheumatoid Arthritis	3.0	4.1	4.3	-2.1	-2.0
Risk taking	3.0	4.4	5.3	-1.9	-2.3
Ever had hysterectomy (womb removed)	2.9	3.3	4.4	-1.5	-2.1
Relative age voice broke	2.9	4.5	4.6	-2.1	-2.1
Health satisfaction	2.9	3.8	6.1	-2.5	-1.3
Basal metabolic rate	2.9	16.3	24.1	-2.9	-4.9
Arm fat-free mass (left)	2.9	14.9	22.9	-2.6	-4.8
Systolic Blood Pressure	2.8	13.8	17.9	3.1	4.2
Serious illness, injury or assault of a close relative in last 2 years	2.7	3.1	3.9	1.5	2.0
Pulse rate	2.6	4.5	5.4	-1.9	-2.3
Eye problems/disorders: None of the above	2.6	3.0	3.5	1.6	1.9
Ever taken oral contraceptive pill	2.6	2.9	4.3	1.2	2.1
Myopia	2.6	3.8	4.6	2.2	1.7
Vitamin and mineral supplements	2.5	3.3	5.7	-2.4	-0.9
Qualifications: CSEs or equivalent	2.5	3.3	5.1	1.2	2.2
Medication: Metformin	2.4	3.4	4.8	-2.2	-1.4
Whole body water mass	2.4	13.5	21.7	-2.3	-4.7
Unable to work because of sickness or disability	2.4	3.1	4.2	-2.0	-1.4
Coronary Artery Disease (CAD)	2.3	2.7	5.2	0.5	2.3
Height	2.3	44.9	50.3	-6.3	-7.1
Number of full brothers	2.3	3.0	3.1	-1.8	-1.7
Whole body fat-free mass	2.3	13.2	21.2	-2.3	-4.6
Leg predicted mass (right)	2.3	12.0	18.9	-2.3	-4.3
Number of self-reported non-cancer illnesses	2.3	3.9	4.9	-1.7	-2.2
Financial situation satisfaction	2.3	2.8	3.9	-1.3	-2.0
Schizophrenia vs Biploar Disorder	2.2	3.0	3.8	2.0	1.4
Leg fat-free mass (left)	2.2	11.4	17.6	-2.3	-4.2
Leg predicted mass (left)	2.2	11.7	18.2	-2.3	-4.3
Knee pain experienced in last month	2.2	3.3	4.6	-1.4	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	5.0	-0.4	2.2
Leg fat-free mass (right)	2.2	11.5	18.2	-2.2	-4.3
HDL Cholesterol	2.1	3.5	5.2	-1.4	-2.3
Cardiovascular Disease	2.1	6.8	9.0	3.0	2.2
Relative age of first facial hair	2.1	4.3	6.3	-2.5	-1.5
Trunk fat-free mass	2.1	11.9	19.6	-2.0	-4.4
Trunk predicted mass	2.1	11.8	19.6	-2.0	-4.4
Medication: Blood pressure	2.1	3.9	5.3	2.3	1.6
BMI	2.0	11.4	12.4	-3.5	-3.2
Lung FVC	2.0	10.1	12.4	3.5	2.8
Chest pain or discomfort	2.0	2.9	4.4	-2.1	-1.2
Eye problems/disorders: Glaucoma	2.0	2.4	3.3	-1.2	-1.8
Allergy or Eczema	1.9	5.1	8.5	-1.3	-2.9
Angina	1.9	2.4	2.9	-1.4	-1.7
Stomach or abdominal pain in last month	1.9	2.4	3.4	-1.1	-1.8
Medication: Atenolol	1.9	2.3	2.8	1.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	2.9	3.2	-1.6	-1.8
Birth weight of first child	1.9	3.4	5.2	-2.3	-1.3
Peak expiratory flow (PEF)	1.9	4.3	5.1	2.2	1.9
Guilty feelings	1.9	2.9	4.8	-1.0	-2.2
Smoking Status	1.8	4.3	5.5	-1.8	-2.3
Gout (self-reported)	1.8	2.4	4.0	-0.9	-2.0
Medication: Blood pressure	1.8	3.2	3.8	2.0	1.6
Friendships satisfaction	1.8	2.3	3.1	1.8	1.2
Noisy workplace	1.7	2.1	2.9	-1.7	-1.2
Ever highly irritable/argumentative for 2 days	1.7	2.0	2.5	-1.6	-1.2
Respiratory disease	1.6	3.5	4.1	-2.0	-1.7
Type 2 Diabetes (T2D) (2012)	1.5	1.8	2.6	-1.0	-1.6
Chronotype (morning person)	1.5	3.5	4.7	-2.2	-1.5
Pack years adult smoking proportion	1.5	2.2	3.1	-1.8	-1.1
Loud music exposure frequency	1.5	1.6	2.5	1.6	0.9
Shortness of breath walking on level ground	1.5	1.8	2.6	-1.6	-1.0
Blood Red Count	1.4	13.8	26.9	0.9	5.2
Qualifications: None of the above	1.4	3.0	4.3	-2.1	-1.3
Medication: Simvastatin	1.4	2.0	2.6	-1.2	-1.6
Father’s age at death	1.4	1.9	2.8	-1.7	-1.0
Pulse wave reflection index	1.4	1.7	2.3	1.1	1.5
High blood pressure (siblings)	1.4	2.0	3.2	1.8	0.9
Alcohol intake frequency.	1.4	3.2	6.0	0.7	2.4
Number of full sisters	1.4	1.7	2.3	-1.5	-1.0
Mother’s age at death	1.4	1.7	3.5	-0.1	-1.9
Major Depression (MDD)	1.3	1.6	1.7	1.3	1.2
Blood Eosinophil Count	1.3	10.0	14.2	2.4	3.8
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.2	-1.5	-0.9
Angina (self-reported)	1.3	1.8	2.5	-1.0	-1.6
Medication: Ibuprofen	1.3	1.5	3.0	0.1	-1.7
Eye problems/disorders: Cataract	1.3	1.5	2.7	1.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	4.2	1.1	2.0
Miserableness	1.3	2.3	2.3	1.5	1.5
Pain type(s) experienced in last month: Hip pain	1.3	1.6	2.3	-1.0	-1.5
Impedance of arm (right)	1.2	5.7	9.4	1.4	3.1
Suffer from ‘nerves’	1.2	1.8	2.3	1.2	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.1	-1.4	-0.8
Mean Putamen Volume	1.1	1.2	1.6	1.3	0.9
Hypothyroidism (self reported)	1.1	2.5	2.6	-1.6	-1.6
Mouth/teeth dental problems	1.1	1.7	3.0	0.7	1.7
Allergy	1.1	2.5	4.7	0.5	2.2
Happiness	1.1	1.4	1.8	-1.0	-1.3
Lung cancer (father)	1.1	1.3	1.8	-0.9	-1.3
Exposure to tobacco smoke outside home	1.1	1.4	1.6	1.1	1.3
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.4	-1.2	-0.9
Supplements: Zinc	1.0	1.1	1.2	1.1	0.9
Hand grip strength (right)	1.0	2.6	3.7	-1.2	-1.9
Average weekly fortified wine intake	1.0	1.2	1.6	-1.3	-0.8
Taking other prescription medications	1.0	1.6	1.9	-1.4	-1.1
Falls in the last year	1.0	1.3	2.5	-0.4	-1.6
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	5.7	2.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	2.4	-0.2	-1.6
Wheeze or whistling in the chest in last year	1.0	1.7	2.0	-1.4	-1.2
Comparative height size at age 10	1.0	5.3	7.2	2.7	1.9
Commuting to job workplace: Walk	1.0	1.1	2.0	1.4	0.3
Medication: Aspirin	1.0	1.4	2.3	1.5	-0.6
Illnesses of father: High blood pressure	1.0	1.2	1.3	1.1	1.1
Pack years of smoking	1.0	1.5	1.8	-1.3	-1.1
Maternal smoking around birth	0.9	1.3	2.1	-0.7	-1.4
Had other major operations	0.9	1.0	1.7	-0.6	-1.3
Medication: Lansoprazole	0.9	1.0	1.4	-0.8	-1.2
Impedance of arm (left)	0.9	4.3	7.5	1.0	2.7
Breastfed as a baby	0.9	1.1	1.5	-1.2	-0.8
Glaucoma (self-reported)	0.9	1.0	1.7	-0.6	-1.3
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.1	-0.1	-1.4
Commuting to job workplace: Car/motor vehicle	0.9	1.1	2.0	-1.4	-0.4
Hypertension (Self-reported)	0.9	2.4	4.4	2.1	0.6
Loneliness, isolation	0.9	1.2	1.9	-1.4	-0.7
Depression (Nagel 2018)	0.8	1.2	1.3	1.1	1.1
Medication for hormone replacement therapy	0.8	0.9	1.8	-1.3	-0.0
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.4	-0.1	-1.9
Medication: Levothyroxine sodium	0.8	1.4	2.2	-1.5	-0.7
Forced vital capacity (FVC)	0.8	3.1	5.2	2.3	1.0
Birth weight	0.8	1.7	2.0	1.4	1.2
Medication for pain relief, constipation, heartburn	0.8	1.4	2.5	0.6	1.6
Medication: Aspirin	0.8	1.0	1.9	1.4	-0.3
Osteoporosis (self-reported)	0.8	1.0	1.5	-1.2	-0.7
Medication: Bendroflumethiazide	0.8	1.2	2.0	1.4	0.6
Impedance of whole body	0.8	3.9	7.3	0.8	2.7
Bipolar Disorder (2018)	0.7	1.1	1.3	-0.9	-1.1
Neuroticism (2016)	0.7	1.0	1.1	1.1	-0.9
Supplements: Glucosamine	0.7	0.9	1.0	-0.9	-1.0
Hair/balding pattern: Pattern 2	0.7	0.8	1.0	0.8	-1.0
Mouth/teeth dental problems: Dentures	0.7	1.2	1.3	-1.1	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	3.0	1.7	1.1
Emphysema/chronic bronchitis	0.7	0.8	1.2	-1.1	-0.6
Medication: Allopurinol	0.7	0.9	1.8	-0.3	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.1	-0.9	-1.0
Alcohol drinker status: Never	0.7	0.8	1.5	1.2	0.4
High blood pressure	0.6	1.5	3.0	1.7	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.2	0.9	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.7	0.2	-1.6
Pain all over the body in last month	0.6	0.6	1.2	-1.1	-0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.2	1.5	0.5
Depression (self-reported)	0.6	0.7	1.2	1.1	0.3
Prospective memory result	0.6	0.8	1.3	-1.2	-0.4
Length of working week for main job	0.6	0.7	1.3	1.2	0.2
Forced vital capacity (FVC), Best measure	0.6	2.3	3.5	1.9	1.0
Number of children fathered	0.6	0.7	1.0	1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	0.7	-0.8	-0.8
Asthma (self-reported)	0.6	1.3	2.0	-1.4	-0.7
Hearing aid user	0.6	0.7	1.1	-0.4	-1.1
Irritability	0.6	1.0	1.9	-0.2	-1.4
Fasting Glucose	0.5	0.6	1.2	-1.1	-0.1
LDL Cholesterol	0.5	0.7	1.5	0.0	-1.2
Average weekly spirits intake	0.5	0.6	1.1	-1.1	0.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	0.8	-0.7	-0.9
Diabetes (mother)	0.5	0.7	0.9	-0.7	-0.9
Impedance of leg (right)	0.5	2.3	4.4	0.3	2.1
Asthma	0.5	1.1	1.6	-1.3	-0.7
Illnesses of mother	0.5	0.6	1.1	-0.4	-1.0
Pulse wave Arterial Stiffness index	0.5	0.5	0.8	-0.9	-0.5
Standing height	0.5	5.3	9.7	-1.0	-3.1
Medication: Omeprazole	0.5	0.5	0.9	-0.9	0.4
Medication: Seretide 50 evohaler	0.5	0.6	1.3	-1.1	-0.1
Heart disease (mother)	0.5	0.6	1.1	-0.2	1.1
Mood swings	0.5	1.0	1.5	-1.2	-0.7
Medication for cholesterol	0.5	0.7	1.0	-1.0	-0.7
Alcohol drinker status: Previous	0.5	0.6	1.0	-0.4	1.0
Schizophrenia (2014)	0.4	1.0	1.5	-0.7	-1.2
Number of treatments/medications taken	0.4	0.8	1.3	-0.5	-1.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.6	0.6	0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-1.0	-0.1
Diabetes (father)	0.4	0.6	1.0	-0.3	-1.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.5	-0.5	-0.7
Financial difficulties in last 2 years	0.4	0.5	0.8	-0.9	-0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.7	0.8	0.6
Medication: Ramipril	0.4	0.5	0.5	0.7	0.7
Fluid intelligence score	0.4	0.8	1.4	0.5	1.2
Number of live births	0.4	0.5	0.6	-0.7	-0.8
Tense / ‘highly strung’	0.4	0.7	1.3	-1.1	-0.3
Headache pain in last month	0.4	0.7	1.1	-1.1	-0.6
Comparative body size at age 10	0.4	1.0	1.9	-0.3	-1.4
Age at first live birth	0.4	0.6	1.1	0.3	1.1
Qualifications: nursing, teaching	0.4	0.7	0.9	-1.0	-0.6
Medication: Atorvastatin	0.4	0.6	0.6	0.8	0.7
Fractured/broken bones in last 5 years	0.4	0.5	0.9	-1.0	-0.4
Commuting to job workplace: Cycle	0.4	0.4	0.7	0.9	0.4
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	-0.0	0.9
Worry (Nagel 2018)	0.3	0.7	0.9	0.9	0.8
Alzheimer’s Disease (in mother)	0.3	0.4	0.4	0.6	0.6
Waist Hip Ratio (WHR)	0.3	1.3	2.1	-0.7	-1.4
Hand grip strength (left)	0.3	0.9	1.7	0.4	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	0.7	0.8	0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	0.6	-0.5	-0.8
Impedance of leg (left)	0.3	1.4	2.9	-0.0	1.7
Hearing difficulty/problems with background noise	0.3	0.5	0.9	-0.1	-1.0
Illnesses of siblings	0.3	0.4	0.6	0.8	0.5
Medication: Cholesterol lowering	0.3	0.5	1.0	-0.3	-1.0
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	-0.4	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.6	0.8	-0.1
Age at last live birth	0.3	0.4	0.8	-0.9	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.5	0.4	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	0.8	0.4
Breast cancer (self-reported)	0.3	0.3	0.6	-0.7	-0.2
Medication: Gliclazide	0.3	0.4	0.7	0.2	0.9
Smoking status: Current	0.3	0.4	0.6	-0.5	-0.8
Average weekly champagne plus white wine intake	0.3	0.4	0.5	0.7	0.5
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.3	-1.0
Average weekly beer plus cider intake	0.3	0.4	0.6	-0.5	-0.8
Age started oral contraceptive pill	0.3	0.3	0.4	0.6	-0.5
Ever depressed for a whole week	0.3	0.4	0.5	-0.5	-0.7
Cholesterol lowering medication	0.3	0.4	0.8	0.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.5	-0.7	0.5
Crohns Disease (2017)	0.2	0.3	0.7	-0.0	0.8
Reaction Time	0.2	0.4	0.7	0.4	0.8
Crohns Disease (2012)	0.2	0.4	0.7	0.1	0.9
HbA1C	0.2	0.3	0.5	-0.7	-0.1
Lupus	0.2	0.3	0.5	0.7	0.2
Ulcerative Colitis	0.2	0.3	0.5	-0.7	0.4
Lung FEV1/FVC ratio	0.2	1.2	2.4	-1.5	-0.1
Systolic blood pressure, automated reading	0.2	0.5	1.0	0.0	1.0
Current tobacco smoking	0.2	0.4	0.4	-0.5	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.8	0.4	-0.9
Serious illness, injury or assault to yourself	0.2	0.3	0.6	-0.7	-0.0
Sitting height	0.2	1.5	2.9	-0.4	-1.7
Had menopause	0.2	0.2	0.4	0.6	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.4	0.4	0.6
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	-0.5	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	-0.7	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.9	-1.0	0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.4	0.5	0.6
Worry too long after embarrassment	0.2	0.4	0.7	0.9	0.2
Pulse wave peak to peak time	0.2	0.2	0.5	0.7	0.0
Mean time to correctly identify matches	0.2	0.4	0.4	0.6	0.6
Average weekly red wine intake	0.2	0.4	0.5	-0.5	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.5	0.3
Ever had bowel cancer screening	0.2	0.3	0.4	0.6	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	0.5	0.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.3	-0.4	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.3	-1.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.5	0.1	0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.4	-0.4	-0.6
Depressed Affect (Nagel 2018)	0.1	0.1	0.2	-0.3	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.3	-0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.2	-0.1	0.5
Breast Cancer	0.1	0.3	0.4	-0.4	-0.6
Triglycerides	0.1	0.2	0.4	0.2	-0.6
Hair Pigment	0.1	3.3	5.7	0.9	2.4
Sensitivity / hurt feelings	0.1	0.1	0.1	0.3	-0.3
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	-0.1
Fed-up feelings	0.1	0.2	0.4	0.1	-0.6
Alcohol usually taken with meals	0.1	0.2	0.2	0.4	0.4
Nervous feelings	0.1	0.2	0.4	0.6	0.2
Heart attack	0.1	0.1	0.2	0.5	0.0
Neuroticism score	0.1	0.2	0.3	0.3	-0.5
Time employed in main current job	0.1	0.1	0.1	-0.3	-0.4
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.1	-0.4
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.2	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.0	0.5
Supplements: Vitamin C	0.1	0.2	0.2	-0.4	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	-0.1	-0.4
Supplements: Calcium	0.1	0.1	0.1	0.3	0.4
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.5	0.2
Neuroticism (Nagel 2018)	0.0	0.1	0.2	0.2	-0.4
Schizophrenia (2018)	0.0	0.0	0.1	0.3	0.1
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.3	0.2
Ulcerative Colitis (UC)	0.0	0.1	0.1	-0.2	-0.3
Prostate Cancer	0.0	0.1	0.1	-0.3	0.1
Age at First Birth	0.0	0.1	0.1	-0.3	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	0.3	0.1
Primary Biliary Cirrhosis	0.0	0.0	0.1	-0.3	-0.0
Heel T-Score	0.0	0.2	0.2	0.5	0.4
Neuroticism	0.0	0.1	0.2	0.4	-0.1
Tanning	0.0	0.2	0.3	0.6	-0.0
Severe depression (siblings)	0.0	0.0	0.1	0.3	0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.0	0.0
Worrier / anxious feelings	0.0	0.1	0.2	0.0	-0.4
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.1	0.1	0.4	0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.0	0.1	0.2
Qualifications: College or University degree	0.0	0.0	0.0	0.2	0.1
Had major operations	0.0	0.0	0.1	-0.3	-0.0
Family relationship satisfaction	0.0	0.1	0.1	0.3	-0.2
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.0	-0.1	0.0
Mineral and other dietary supplements	0.0	0.0	0.1	-0.2	0.3
Illnesses of father: None of the above (group 1)	0.0	0.0	0.1	-0.0	0.2
Diastolic blood pressure, automated reading	0.0	0.0	0.1	-0.3	0.1

Hub : Genes

MEG3

Models

Trait associations