Hub : Genes

METTL22

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.0936	0.0342	3.2e-03	-0.003	NA	0.011	NA	0.003	8.6e-01	NA	4.3e-02	NA	1.9e-01
2	GTEx	Brain Cerebellar Hemisphere	0.3480	0.1090	4.8e-03	0.170	NA	0.130	NA	0.160	3.9e-05	NA	3.4e-04	NA	6.8e-05
3	GTEx	Brain Cerebellum	0.7260	0.0790	1.4e-08	0.321	NA	0.325	NA	0.323	3.2e-10	NA	2.4e-10	NA	2.8e-10
4	GTEx	Cells Transformed fibroblasts	0.1420	0.0430	3.1e-04	0.049	NA	0.149	NA	0.146	1.4e-04	NA	2.8e-11	NA	4.7e-11
5	GTEx	Heart Left Ventricle	0.1617	0.0534	2.2e-03	0.139	NA	0.143	NA	0.143	7.6e-08	NA	4.9e-08	NA	5.1e-08
6	GTEx	Muscle Skeletal	0.2063	0.0391	4.3e-09	0.166	NA	0.198	NA	0.196	4.7e-16	NA	3.7e-19	NA	5.9e-19
7	GTEx	Skin Sun Exposed Lower leg	0.0990	0.0400	9.5e-03	0.004	NA	-0.002	NA	-0.001	1.3e-01	NA	5.9e-01	NA	4.0e-01
8	GTEx	Testis	0.2880	0.0750	1.1e-03	0.240	NA	0.158	NA	0.216	5.2e-11	NA	1.6e-07	NA	6.2e-10
9	ROSMAP	Brain Pre-frontal Cortex	0.0510	0.0198	5.7e-03	0.063	0.01	0.046	0.041	0.056	1.6e-08	0.017	1.1e-06	5.1e-06	9.0e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	0.2	0.3	1.1	-0.3	1.0	0.1	0.9	-0.1	-0.5	0.3	0.1	0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	2.3	-1.5	1.2	0.1	-0.1	-0.5	-0.9	-0.7	0.5	1.1
Depressed Affect (Nagel 2018)	0.1	0.3	1.1	-0.0	-0.6	0.1	-0.8	-0.4	-0.0	-1.1	0.2	-0.1
Depression (Nagel 2018)	1.1	1.7	5.3	2.2	-1.7	-2.3	0.2	0.6	0.2	0.2	-0.3	-1.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.4	0.1	-2.1	-1.7	-1.2	-0.6	-0.7	-0.8	1.0	-0.6
Neuroticism (Nagel 2018)	0.4	1.0	1.9	0.3	-1.4	-1.1	-1.2	-0.4	-0.3	-1.4	0.8	-1.4
Schizophrenia (2018)	0.4	0.8	2.6	-1.6	0.7	0.1	-0.9	-0.6	-0.8	-1.1	0.6	0.8
Schizophrenia vs Biploar Disorder	0.4	0.5	2.8	-0.7	0.6	1.7	-0.2	0.1	0.6	-0.1	-0.2	0.7
Worry (Nagel 2018)	0.6	1.3	3.5	0.6	-1.8	-1.4	-0.8	-0.2	-0.4	-1.0	0.8	-1.9
Alzheimer’s Disease (in mother)	0.8	0.9	1.6	-0.9	1.2	-0.1	-1.3	-1.1	-0.5	-1.0	0.8	1.0
Alzheimer’s Disease (in father)	1.7	1.8	4.0	-0.2	-0.9	0.6	1.4	1.4	1.5	1.9	-2.0	-1.0
Alzheimer’s Disease (including proxy)	0.3	0.5	1.4	-0.4	-0.1	0.3	0.2	0.6	1.1	1.0	-1.2	-0.3
Crohns Disease (2017)	1.3	2.8	7.0	0.7	-0.1	0.6	1.0	2.5	2.6	2.4	-1.9	-0.3
Irritable Bowel Disease (IBD)	0.2	0.4	1.2	-1.1	0.8	0.8	-0.3	-0.0	-0.0	0.1	0.5	0.8
Ulcerative Colitis (UC)	1.5	2.8	4.7	-2.2	1.3	0.8	-1.0	-1.9	-2.1	-1.6	2.1	1.4
Major Depression (MDD)	0.2	0.2	0.5	0.6	-0.6	-0.6	0.7	0.4	0.2	0.2	-0.1	-0.5
Reaction Time	0.3	0.7	1.8	0.6	-1.3	-1.0	0.4	0.4	0.3	0.7	-0.2	-1.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	4.4	0.3	-2.1	-1.4	-0.1	0.1	-0.5	-0.8	0.6	-1.2
Breast Cancer	1.0	2.3	7.8	1.0	-2.7	-1.2	1.1	1.2	0.5	0.5	-0.4	-2.8
Ovarian Cancer	1.7	2.2	7.6	0.5	-1.8	-2.3	-1.2	0.9	0.6	0.9	-0.2	-2.8
Prostate Cancer	0.1	0.1	0.6	0.4	-0.1	-0.3	0.8	0.0	-0.1	0.3	-0.2	-0.0
Age at First Birth	0.5	0.8	2.0	-0.8	0.9	1.4	-0.2	0.5	1.1	0.9	-1.0	0.6
Bipolar Disorder (2011)	0.5	0.4	1.2	0.8	-0.4	-1.1	0.8	0.0	-0.5	0.6	-0.1	-0.8
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	-0.4	0.5	1.2	0.7	-0.0	0.2	0.7	0.2	1.0
Coronary Artery Disease (CAD)	1.4	1.7	3.2	1.7	-1.4	-0.6	1.2	1.1	0.9	1.8	-1.1	-1.4
Crohns Disease (2012)	0.2	0.3	1.2	-0.3	1.0	1.1	0.1	0.2	0.3	0.3	-0.0	0.4
Mean Putamen Volume	0.5	0.6	1.2	1.0	-0.7	0.2	0.4	1.0	1.1	0.7	-0.8	-0.7
Fasting Glucose	0.4	0.4	1.7	0.1	-0.2	-0.3	1.3	-0.3	-1.0	-0.3	0.9	-0.6
HbA1C	2.2	2.5	5.5	2.4	-0.6	-0.4	1.4	1.9	1.7	2.0	-1.6	-1.1
HDL Cholesterol	0.2	0.3	0.9	0.6	-0.1	-0.2	-0.0	0.6	0.9	0.9	-0.7	0.0
LDL Cholesterol	0.3	0.5	1.1	-0.4	-0.1	-0.1	-1.0	-1.0	-0.6	-0.7	1.0	0.2
Lupus	1.6	2.4	4.9	-1.7	-0.5	-0.3	-2.2	-1.9	-1.3	-2.1	1.9	-0.5
Neuroticism (2016)	0.3	0.4	0.9	-0.2	-0.8	-0.4	-0.9	-0.6	-0.1	-0.9	0.6	-0.5
Primary Biliary Cirrhosis	0.2	0.3	1.4	1.2	-0.3	0.2	0.8	0.3	0.4	-0.1	-0.6	-0.0
Rheumatoid Arthritis	0.6	0.8	2.4	-0.3	-1.5	-0.3	-0.5	-0.5	-0.8	-1.0	1.1	-1.1
Schizophrenia (2014)	1.0	2.3	4.9	-1.9	1.2	-0.1	-1.2	-1.5	-1.8	-2.2	1.7	0.9
Triglycerides	0.3	0.4	1.9	0.1	0.1	1.1	1.4	0.2	0.1	0.3	-0.3	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.0	0.6	-0.3	0.6	0.1	0.7	1.0	0.7	-0.6	0.6
Ulcerative Colitis	4.0	5.8	9.4	-2.8	1.9	1.1	-1.8	-3.0	-3.1	-2.5	2.9	2.0
Blood Eosinophil Count	0.1	0.5	2.2	-0.3	-0.8	0.1	0.5	0.5	0.5	1.5	-0.6	-0.8
Blood Platelet Count	0.1	0.7	2.0	-0.6	1.2	1.4	-1.4	-0.3	0.1	-0.4	0.4	0.8
Blood Red Count	0.1	0.9	3.4	-0.4	-0.1	0.7	0.0	1.2	1.9	1.1	-1.2	0.3
Blood White Count	0.2	1.5	2.9	-0.1	0.1	1.3	0.9	1.4	1.7	1.6	-1.7	0.3
Heel T-Score	0.1	0.5	1.4	1.2	-0.7	0.1	0.5	0.2	0.4	1.1	-0.6	-0.6
BMI	0.2	1.3	3.0	-1.7	1.4	1.1	-1.5	-0.9	-0.1	-0.3	0.2	1.4
Height	0.2	3.9	12.4	-1.6	2.9	3.5	1.1	0.3	-0.1	1.0	-0.2	3.1
Waist Hip Ratio (WHR)	0.8	3.5	12.1	-2.3	3.1	1.9	0.3	-0.4	0.0	0.4	-0.3	3.5
Systolic Blood Pressure	0.3	1.3	2.3	0.4	1.2	1.4	1.3	1.0	1.1	1.4	-1.5	0.2
Smoking Status	0.3	0.7	1.8	1.0	-1.4	-0.8	0.7	-0.2	-0.8	0.6	0.2	-0.9
Allergy or Eczema	0.3	0.7	1.3	0.4	0.9	-0.5	-0.5	-1.1	-0.9	-1.1	0.8	1.0
Cardiovascular Disease	0.2	0.6	1.9	-1.4	1.1	0.7	-0.9	-0.6	0.3	0.3	-0.2	0.4
Hypothyroidism (self reported)	0.5	1.0	3.3	-1.3	1.4	0.8	-0.6	-0.3	0.6	0.6	-0.7	1.8
Respiratory disease	1.1	2.5	7.4	0.9	-2.1	-2.7	-0.4	-0.5	-1.1	-1.5	1.5	-1.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.3	-0.0	-0.3	1.1	0.8	0.6	0.7	0.6	-0.9	-0.1
Lung FEV1/FVC ratio	0.3	1.5	4.1	1.4	-2.0	-2.0	-0.6	0.4	0.1	0.0	0.6	-1.7
Lung FVC	2.2	11.0	32.0	-2.5	4.1	5.7	2.0	0.7	1.3	1.9	-2.0	5.5
Neuroticism	0.1	0.3	0.9	0.4	-0.8	-0.3	-0.4	0.2	0.5	-0.4	-0.2	-1.0
Chronotype (morning person)	2.8	6.5	11.9	-3.5	3.3	1.0	-2.2	-2.9	-2.3	-1.9	2.4	2.6
Hair Pigment	0.0	0.3	0.5	-0.6	0.6	-0.7	-0.6	-0.6	-0.6	-0.1	0.6	0.2
Tanning	0.0	0.3	0.6	-0.6	-0.5	0.4	-0.3	-0.4	-0.4	-0.7	0.4	-0.8
Hand grip strength (left)	0.8	2.0	6.5	-1.3	2.3	1.3	0.4	-1.1	-1.1	0.5	0.4	2.5
Number of treatments/medications taken	0.6	1.1	3.4	-1.5	1.9	-0.5	-0.6	-0.1	0.4	0.7	-0.5	1.7
Average weekly spirits intake	1.1	1.4	4.8	1.1	-1.7	-1.4	-0.8	0.7	0.7	-0.0	-0.1	-2.2
Sensitivity / hurt feelings	0.2	0.4	2.2	-0.9	0.3	0.1	-1.5	-0.1	0.6	-0.5	0.2	0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.5	1.3	-1.1	-1.9	0.6	0.6	-0.1	0.4	-0.3	-0.6
Hearing difficulty/problems: Yes	0.4	0.7	2.9	-0.5	-0.1	1.1	-1.7	-0.1	1.0	-0.7	-0.1	0.3
Relative age of first facial hair	0.1	0.2	0.7	-0.5	-0.2	-0.1	-0.9	0.0	0.3	-0.3	0.0	-0.4
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	5.2	0.6	-0.9	-1.2	0.4	2.3	2.2	1.9	-1.8	-0.8
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.8	-0.4	-0.4	0.3	-0.4	0.7	1.3	0.9	-1.0	-0.0
Ever had hysterectomy (womb removed)	0.5	0.6	2.4	-1.6	0.2	-0.4	-0.7	-0.4	-0.7	-0.9	0.6	0.6
Systolic blood pressure, automated reading	0.6	1.6	4.4	-1.3	2.1	0.8	-1.2	-1.4	-0.9	-1.1	1.1	1.2
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	3.1	-1.7	1.6	0.9	0.3	-0.8	-1.1	-0.2	0.5	1.8
Angina	0.2	0.3	1.1	-0.7	1.1	0.5	-0.4	-0.5	-0.3	-0.2	0.4	0.4
Medication for hormone replacement therapy	1.9	2.2	5.7	1.5	-0.5	0.0	1.4	1.7	1.5	2.4	-2.1	0.2
Vitamin and mineral supplements	0.2	0.3	1.9	-0.2	-0.9	-0.3	-0.1	-0.1	-0.4	-0.1	0.3	-1.4
Supplements: Zinc	0.3	0.3	1.2	-0.0	0.5	-0.6	-0.7	-0.0	0.5	-0.3	-0.3	1.1
Medication: Co-codamol	0.1	0.2	0.3	-0.1	0.5	-0.3	-0.6	-0.4	-0.5	-0.2	0.4	0.4
Medication: Metformin	0.3	0.4	1.6	-1.1	-0.0	1.3	-0.3	-0.4	-0.3	-0.1	0.2	0.2
Diabetes (father)	0.9	1.2	4.2	-2.0	1.0	0.3	-0.8	-0.6	-0.5	-1.3	0.4	1.5
Diabetes (mother)	0.7	0.9	1.8	-0.6	1.3	1.4	0.4	0.8	0.9	0.9	-1.0	1.0
Severe depression (siblings)	0.1	0.1	0.3	0.5	-0.3	0.3	-0.0	0.1	-0.2	-0.5	0.2	-0.4
Pack years adult smoking proportion	0.7	1.1	4.0	0.6	-2.0	-1.6	-0.7	0.5	0.6	-0.0	0.0	-1.5
Impedance of leg (right)	0.3	1.3	2.2	1.4	-1.0	0.8	1.5	1.4	0.9	1.1	-1.1	-1.1
Leg fat-free mass (left)	0.3	1.7	4.0	-1.6	2.0	1.7	-0.8	-0.0	0.7	0.4	-0.5	2.0
Trunk fat percentage	0.4	1.7	3.2	-1.3	1.7	1.8	-1.3	0.3	1.5	0.7	-1.0	1.4
Hand grip strength (right)	1.2	3.2	9.1	-1.6	2.7	3.0	1.0	-0.2	-0.1	1.3	-0.6	2.6
Townsend deprivation index at recruitment	0.6	0.8	2.7	-1.1	1.1	1.0	-0.7	0.1	0.6	-0.1	-0.0	1.6
Current tobacco smoking	0.3	0.5	2.0	1.1	-1.4	-1.1	0.1	-0.1	-0.1	-0.1	0.1	-0.0
Average weekly fortified wine intake	1.2	1.4	4.3	0.8	-1.5	-2.1	-1.1	0.2	-0.1	-0.7	0.7	-1.7
Maternal smoking around birth	0.3	0.5	2.1	0.2	-1.1	-0.9	0.2	0.4	0.4	0.3	-0.0	-1.5
Fed-up feelings	0.6	1.1	2.8	-0.8	1.3	0.6	-1.2	-0.8	-0.3	-1.3	0.8	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.5	1.8	-1.3	-1.9	0.2	0.9	0.7	0.8	-0.8	-0.6
Relative age voice broke	0.4	0.6	1.6	-0.9	-0.7	-0.4	-1.2	-0.3	0.0	-1.3	0.6	-0.6
Taking other prescription medications	0.4	0.6	1.4	-0.7	0.5	-0.0	0.2	0.7	0.9	0.9	-1.2	1.1
Age when periods started (menarche)	0.6	1.3	3.5	-1.9	1.4	1.6	-0.1	-0.8	-1.2	0.3	0.8	1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.8	-0.7	-0.8	-1.4	-1.7	-0.6	-0.3	-1.4	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.3	0.6	0.2	0.7	0.2	1.0	1.4	1.5	-1.3	-0.4
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	-0.7	0.5	0.0	-0.7	-0.6	-0.3	-0.4	0.5	0.9
Qualifications: CSEs or equivalent	0.4	0.5	2.0	-0.6	0.5	-0.2	-0.1	-0.9	-1.4	-0.5	1.0	-0.4
Serious illness, injury or assault to yourself	1.3	1.6	4.5	1.6	-1.7	-2.1	0.4	1.0	0.4	-0.3	-0.0	-1.8
High blood pressure	0.4	1.1	3.2	-1.5	1.8	1.0	-0.1	-0.2	0.5	1.1	-0.6	1.2
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.7	0.5	1.1	0.1	0.0	-0.5	-0.5	-0.9	0.5	1.3
Multivitamins +/- minerals	1.1	1.4	4.7	0.7	1.4	0.8	0.4	0.7	1.4	0.8	-1.2	2.2
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.0	-0.7	0.4	-0.5	0.5	0.7	-0.3	-0.3	-0.2
Supplements: Glucosamine	0.2	0.3	0.8	0.6	0.4	0.1	0.4	0.6	0.9	0.3	-0.7	0.6
Diverticular disease/diverticulitis (self-reported)	1.0	1.1	3.4	-1.5	1.7	1.9	0.1	-0.1	0.1	0.3	-0.5	1.0
Medication: Atenolol	0.8	1.0	2.0	0.4	0.2	1.0	1.0	1.0	1.2	1.4	-1.3	0.3
Medication: Levothyroxine sodium	0.3	0.5	2.2	-0.9	0.4	-0.1	-1.5	-0.7	0.1	0.3	0.3	0.3
Sitting height	0.1	0.8	4.0	0.7	0.2	2.0	0.2	0.8	1.0	0.4	-0.7	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	0.4	-0.3	0.4	0.2	0.5	0.2	0.1	-0.3	-0.1
High blood pressure (mother)	0.3	0.4	2.4	0.3	0.2	-1.5	-0.5	0.1	0.5	0.5	0.1	0.4
Body mass index (BMI)	0.3	1.1	2.2	-1.5	1.2	1.1	-1.2	-0.2	0.9	0.4	-0.6	1.5
Impedance of leg (left)	0.2	1.1	1.7	0.9	-0.7	1.0	1.2	1.3	1.1	1.3	-1.1	-0.9
Leg predicted mass (left)	0.3	1.7	4.0	-1.6	2.0	1.7	-0.8	0.1	0.8	0.5	-0.6	2.0
Trunk fat mass	0.5	2.0	4.0	-1.3	1.9	2.0	-1.2	0.4	1.6	0.9	-1.1	1.7
Waist circumference	1.1	3.9	10.6	-2.5	3.0	2.5	-1.2	-0.4	0.9	0.5	-0.6	3.2
Number of incorrect matches in round	0.0	0.0	0.2	0.1	-0.0	0.3	0.1	0.2	0.5	-0.1	-0.2	0.1
Past tobacco smoking	0.8	1.4	4.1	-0.6	1.3	1.5	-0.2	1.2	2.0	0.8	-1.1	1.1
Alcohol usually taken with meals	0.0	0.1	0.2	0.1	0.2	0.1	-0.3	-0.4	0.0	0.2	0.1	0.3
Nervous feelings	0.6	1.1	4.6	0.9	-1.7	-0.9	-0.2	0.4	-0.0	0.3	0.3	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.7	0.9	0.2	-0.0	-0.1	-0.4	-0.2	0.3	1.0
Hearing difficulty/problems with background noise	0.6	0.9	2.0	-1.3	0.9	0.3	-1.1	-1.0	-0.5	-0.7	0.7	1.4
Hair/balding pattern: Pattern 2	0.2	0.2	0.7	-0.1	-0.2	-0.5	0.8	0.3	-0.3	0.4	0.3	-0.7
Had menopause	0.7	0.9	1.7	-1.1	0.8	0.3	-1.1	-1.3	-0.8	-0.8	1.2	0.6
Had other major operations	0.3	0.4	1.1	0.7	-0.7	-1.1	0.2	0.6	0.8	0.2	-0.1	-0.5
Forced vital capacity (FVC)	1.8	6.8	20.6	-2.4	3.6	4.5	1.4	-0.4	-0.3	0.8	-0.7	4.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	0.1	0.1	0.8	-0.5	0.4	1.1	0.7	-0.8	0.1
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	6.2	-1.5	1.1	-0.6	-0.7	-1.7	-1.5	-1.7	1.5	2.5
Qualifications: None of the above	0.2	0.4	1.6	0.1	0.1	1.3	-0.9	0.0	0.9	0.7	-0.1	0.5
Financial difficulties in last 2 years	0.1	0.1	0.6	-0.8	0.2	-0.6	0.0	0.5	0.0	0.0	0.2	-0.1
Mouth/teeth dental problems	1.6	2.4	4.9	-2.0	2.1	0.6	-2.2	-1.7	-0.8	-1.0	1.2	1.2
Heart attack	1.1	1.4	4.6	1.1	-1.9	-2.1	-0.4	-0.0	-0.3	-0.0	0.8	-1.5
Allergy	0.4	0.8	1.9	-1.1	0.7	1.4	0.2	0.6	0.9	1.1	-1.0	0.6
Pain all over the body in last month	1.3	1.4	3.0	-0.0	0.7	0.3	0.8	1.4	1.6	1.4	-1.7	1.3
Diabetes (self-reported)	0.1	0.1	0.5	-0.0	0.1	0.4	0.7	0.4	0.2	0.4	-0.5	0.2
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	6.3	-0.6	0.3	-1.2	-1.5	-1.7	-1.4	-2.5	1.7	0.9
Medication: Ramipril	0.3	0.4	1.9	0.4	0.1	-0.2	1.4	0.5	0.1	1.1	-0.5	0.3
Medication: Simvastatin	0.1	0.2	0.3	-0.5	0.4	0.6	0.1	-0.4	-0.5	0.1	0.3	0.5
Fluid intelligence score	1.8	3.7	7.9	-0.2	-2.7	-2.8	-1.8	-0.8	-1.4	-2.0	1.9	-2.2
Illnesses of siblings	0.6	0.8	2.7	0.8	-1.5	-0.3	0.6	-0.3	-1.0	-0.0	0.7	-1.6
Neuroticism score	0.1	0.3	0.8	-0.1	-0.6	-0.7	-0.6	0.1	-0.0	-0.9	0.3	-0.5
Weight	0.5	2.3	5.4	-1.7	2.1	2.3	-0.9	-0.1	0.9	0.6	-0.7	2.3
Impedance of arm (right)	0.2	0.8	2.5	0.8	0.9	1.6	1.0	1.0	0.6	0.5	-0.7	-0.1
Arm fat percentage (right)	0.5	2.1	4.7	-1.3	2.2	2.1	-0.6	0.4	1.4	1.0	-1.2	1.8
Trunk fat-free mass	0.2	1.2	3.5	-0.8	1.5	1.8	-0.3	-0.0	0.6	0.7	-0.6	1.9
Hip circumference	0.4	1.7	3.9	-1.6	1.8	2.0	-1.1	-0.2	0.8	0.3	-0.5	1.8
Time employed in main current job	0.2	0.2	0.5	0.2	0.7	0.4	0.4	-0.6	-0.1	0.3	-0.4	0.5
Alcohol intake versus 10 years previously	1.3	1.9	3.8	1.0	-1.2	-0.5	0.4	1.9	1.9	1.6	-1.5	-1.4
Father’s age at death	1.7	2.3	5.7	-2.0	2.4	0.6	-1.3	-1.4	-0.7	-0.6	1.0	2.4
Worrier / anxious feelings	0.1	0.2	0.6	-0.5	-0.1	-0.5	-0.8	0.1	-0.0	-0.4	0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.9	0.1	0.4	0.3	-0.9	1.3	1.7	1.0	-0.9	0.6
Falls in the last year	0.8	1.0	2.4	1.2	-1.3	-1.5	1.0	0.8	0.3	0.7	-0.3	-1.2
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	-0.8	0.6	0.4	-0.8	-0.5	-0.6	-0.5	0.6	0.7
Number of live births	0.2	0.3	1.0	-1.0	0.0	-0.1	-0.3	-0.9	-0.8	0.3	0.5	0.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	10.4	-1.7	2.3	3.2	1.7	0.3	0.0	1.0	-0.8	3.2
Pulse rate	0.7	1.1	2.6	0.0	0.5	-0.3	-0.8	-1.4	-1.6	-1.6	1.4	0.1
Happiness	0.4	0.5	1.5	0.4	-1.1	-1.2	-0.3	-0.3	-0.6	-0.3	0.4	-0.9
Noisy workplace	0.4	0.5	1.6	0.4	0.9	-0.9	0.5	-0.1	0.0	1.3	-0.3	0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.5	-0.7	1.5	2.1	0.9	0.3	0.3	-0.2	-0.9	1.8
Serious illness, injury or assault of a close relative in last 2 years	3.4	3.9	10.0	3.2	-2.7	-1.6	0.7	1.6	1.4	1.2	-1.2	-2.7
Mouth/teeth dental problems: Dentures	2.6	4.4	12.8	2.5	-3.6	-3.3	0.7	0.4	-0.3	-0.0	0.2	-3.0
Asthma	1.3	2.6	6.0	1.5	-2.4	-2.2	-0.5	-0.2	-0.8	-1.4	1.3	-2.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	2.6	-0.7	1.6	0.6	0.5	1.1	1.2	0.9	-1.2	1.3
Medication: Cholesterol lowering	0.2	0.3	0.8	-0.2	-0.1	0.0	-0.4	-0.8	-0.9	-0.1	0.7	-0.4
Depression (self-reported)	0.7	0.8	3.1	-1.8	1.0	-0.3	-1.5	-0.6	-0.1	-0.3	0.2	0.8
Medication: Lansoprazole	0.2	0.2	0.8	-0.1	-0.9	-0.8	-0.2	-0.1	-0.0	-0.1	-0.1	-0.4
Prospective memory result	1.7	2.1	6.2	0.1	1.1	2.5	0.7	1.2	1.9	1.4	-1.7	1.0
Lung cancer (father)	0.7	0.8	1.9	1.0	-1.4	0.7	-0.1	1.0	1.4	-0.0	-0.7	-0.5
Illnesses of mother	0.4	0.5	1.7	-0.5	-1.3	0.7	0.4	-0.2	-0.6	-0.5	0.1	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.7	16.4	-2.0	2.7	4.0	2.1	0.9	0.8	1.5	-1.3	3.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	0.4	-0.4	-1.1	-0.8	-0.4	-0.3	-0.9	0.8	-0.6
Impedance of arm (left)	0.1	0.4	0.9	0.8	0.2	1.0	0.7	0.8	0.2	0.4	-0.4	-0.8
Arm fat mass (right)	0.6	2.5	5.3	-1.7	2.3	2.3	-1.1	-0.0	1.1	0.6	-0.9	2.3
Trunk predicted mass	0.2	1.2	3.3	-0.7	1.4	1.8	-0.2	0.1	0.7	0.8	-0.7	1.8
Standing height	0.2	1.9	7.5	-0.4	2.0	2.7	0.6	0.4	0.5	1.0	-0.7	1.9
Length of working week for main job	1.2	1.3	2.2	1.5	-1.4	0.1	0.8	1.4	1.1	0.8	-1.1	-1.5
Exposure to tobacco smoke at home	0.9	1.0	3.7	1.9	-1.5	0.0	1.2	0.6	0.6	0.4	-0.6	-0.8
Breastfed as a baby	0.7	0.9	3.1	1.1	-0.5	-1.8	-0.9	-0.5	-0.7	-0.2	0.8	-1.1
Tense / ‘highly strung’	1.1	1.8	6.1	1.2	-2.0	-2.5	-0.5	-0.0	-0.5	-1.1	0.6	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	4.8	1.3	-2.2	-1.5	0.5	1.7	1.4	1.5	-1.3	-1.8
Hair/balding pattern: Pattern 4	0.9	2.2	6.4	-1.7	1.8	1.4	-1.5	-1.6	-0.3	-0.3	0.5	2.5
Birth weight of first child	0.1	0.1	0.5	-0.6	0.1	0.7	0.3	-0.1	-0.1	-0.2	0.2	0.4
Peak expiratory flow (PEF)	0.2	0.4	2.0	-0.8	-0.1	0.5	1.4	-0.0	-0.7	-0.1	0.3	0.3
Pulse wave reflection index	0.8	1.0	2.5	0.9	-1.0	-0.4	-0.2	1.5	1.6	0.0	-0.9	-1.1
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.2	0.2	0.0	-2.0	-0.8	-1.1	-1.5	-1.9	1.7	0.1
Loud music exposure frequency	1.3	1.4	3.2	0.7	-0.2	0.1	1.2	1.5	1.8	1.6	-1.7	0.4
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.1	-1.1	0.9	0.3	-1.2	-1.5	-1.5	-1.2	1.2	0.7
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	3.1	-0.1	1.1	1.7	1.1	0.8	0.5	0.5	-0.7	1.7
Blood clot in the leg (DVT)	1.5	2.0	3.3	-1.8	0.6	-0.7	-1.2	-1.8	-1.8	-1.4	1.5	1.1
Medication: Paracetamol	0.3	0.6	1.6	-0.5	0.8	-0.1	-1.3	-0.7	-0.3	-0.8	0.8	0.8
Headache pain in last month	1.7	3.0	8.2	-0.8	2.7	2.9	0.8	0.6	0.6	1.3	-0.8	2.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.2	1.4	-0.2	-0.1	-0.4	-0.4	-0.1	-0.1	-1.2	0.4	0.5
Glaucoma (self-reported)	1.5	1.8	4.3	0.2	0.7	0.7	2.1	1.4	1.0	2.1	-1.5	1.1
Gout (self-reported)	0.6	0.8	2.8	0.2	-1.7	-0.8	-0.9	-0.2	-0.4	-0.4	0.6	-1.4
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.0	-1.1	1.3	0.4	-0.6	-0.2	0.5	0.9	-0.5	1.4
Medication: Amlodipine	2.3	3.2	7.3	1.2	-0.8	-0.7	1.6	2.1	2.3	2.7	-2.3	-1.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	2.2	0.4	-0.7	-1.5	-0.7	-0.1	-0.1	-0.6	0.4	-0.9
Birth weight	0.3	0.7	3.0	-1.7	0.9	0.6	-0.7	-0.7	-0.4	0.2	0.3	1.0
Chronic bronchitis/emphysema (mother)	2.2	2.6	5.0	1.9	-0.4	0.0	1.4	1.9	2.0	2.1	-2.2	0.3
High blood pressure (siblings)	0.5	0.7	2.9	0.1	0.6	-0.1	-0.0	1.0	1.7	0.4	-1.3	0.3
Forced vital capacity (FVC), Best measure	2.7	9.9	31.0	-2.3	3.9	5.6	2.5	0.7	0.9	2.0	-1.9	4.8
Body fat percentage	0.4	1.7	3.2	-1.3	1.7	1.8	-1.1	0.4	1.5	0.9	-1.1	1.4
Leg fat percentage (right)	0.3	1.0	2.2	-0.6	0.9	1.2	-0.6	0.4	1.5	1.0	-1.1	1.1
Arm fat-free mass (right)	0.2	0.9	2.4	-1.4	1.1	1.1	-1.0	-0.2	0.6	0.4	-0.3	1.5
Exposure to tobacco smoke outside home	0.7	0.9	2.6	1.5	-1.6	-0.2	1.0	0.3	-0.5	-1.0	0.4	-1.0
Comparative body size at age 10	0.2	0.6	1.4	-0.8	-0.5	-1.2	-0.8	0.3	0.9	-0.0	-0.5	-1.1
Number of full brothers	0.6	0.8	2.9	-1.7	0.5	0.2	-1.6	-0.7	-0.4	-0.4	0.8	0.1
Worry too long after embarrassment	0.6	1.0	3.5	-1.4	0.2	-0.2	-1.9	-1.0	-0.5	-1.1	0.9	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.6	-0.2	0.6	0.2	0.8	0.6	0.4	0.2	-0.8	1.3
Wheeze or whistling in the chest in last year	0.4	0.6	2.3	0.7	-1.5	-1.1	-0.5	-0.0	0.3	-0.6	0.3	-0.8
Number of children fathered	1.0	1.2	5.5	0.4	-1.4	-2.4	-0.4	-0.3	-0.2	-0.3	0.2	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-0.2	0.6	0.6	1.2	1.1	0.6	0.7	-0.8	0.5
Age at first live birth	0.9	1.6	4.6	-1.0	1.6	2.1	1.5	1.1	0.6	0.7	-0.9	1.1
Pulse wave peak to peak time	0.6	0.7	1.6	-0.4	0.6	1.3	1.0	0.4	0.3	1.2	-0.9	0.9
Health satisfaction	1.6	2.1	6.6	1.6	-2.6	-1.5	0.4	1.4	1.2	0.5	-0.8	-1.7
Shortness of breath walking on level ground	0.4	0.5	1.3	0.7	-0.4	-0.9	0.2	0.8	0.5	1.2	-0.7	-0.2
Qualifications: College or University degree	0.2	0.6	1.7	-1.1	0.8	0.6	-0.1	-0.4	-0.2	-1.3	0.3	1.2
Eye problems/disorders: None of the above	0.6	0.7	1.6	-0.6	0.1	0.2	-0.9	-1.2	-1.1	-0.5	1.3	-0.6
Mouth/teeth dental problems: Loose teeth	1.5	1.8	5.1	1.6	-2.2	-1.6	0.6	-0.1	-1.2	-0.5	1.1	-1.8
Emphysema/chronic bronchitis	0.7	0.8	3.1	1.8	-1.0	-1.5	-0.1	0.3	0.4	0.1	-0.0	-0.2
Medication for pain relief, constipation, heartburn	0.7	1.1	2.8	1.3	-1.3	-0.0	1.7	1.0	0.7	0.8	-0.8	-1.1
Neck or shoulder pain in last month	0.1	0.2	0.4	0.0	0.5	0.5	0.6	0.4	0.2	0.2	-0.4	0.6
Medication: Blood pressure	0.7	1.2	3.6	0.7	-0.0	0.5	1.4	1.1	1.0	1.9	-1.3	-0.4
Angina (self-reported)	0.4	0.6	1.3	-0.8	1.1	0.3	-0.6	-0.9	-0.7	-0.7	0.8	0.5
Migraine (self-reported)	0.6	0.7	2.4	-1.6	0.9	1.5	0.4	0.1	-0.2	0.2	-0.1	1.0
Medication: Ibuprofen	0.8	0.9	3.2	-1.5	1.8	0.4	-0.2	0.2	0.3	0.4	-0.4	1.4
Medication: Allopurinol	0.1	0.1	0.3	0.2	-0.6	-0.1	-0.6	-0.0	0.1	-0.2	0.1	-0.3
Medication: Omeprazole	0.6	0.8	2.3	-0.8	-0.0	-0.7	-1.5	-0.9	-1.1	-0.7	0.9	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.9	0.6	-0.6	-0.1	-0.5	0.1	-0.0	-0.2	0.1	-1.0
Mean time to correctly identify matches	0.3	0.7	2.2	0.7	-1.5	-1.2	-0.1	0.0	0.3	0.5	-0.0	-1.1
Heart disease (mother)	0.3	0.3	1.5	0.1	1.2	0.2	0.0	0.3	0.5	0.4	-0.2	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.6	-0.1	-0.5	-1.3	-1.0	-0.5	-0.5	-1.2	0.8	-0.8
Whole body fat mass	0.5	2.0	3.7	-1.5	1.9	1.9	-1.2	0.2	1.3	0.8	-1.0	1.8
Leg fat mass (right)	0.4	1.6	2.8	-1.5	1.6	1.6	-1.1	0.1	1.2	0.7	-0.9	1.7
Arm predicted mass (right)	0.2	0.8	1.9	-1.3	0.9	1.2	-1.0	-0.2	0.6	0.3	-0.3	1.4
Pulse rate, automated reading	0.5	1.7	5.1	0.2	2.3	1.6	-1.3	-0.5	0.6	-0.8	0.2	2.1
Alcohol intake frequency.	0.8	1.9	4.4	-0.4	0.6	1.0	0.7	1.8	2.1	1.8	-1.9	1.0
Comparative height size at age 10	0.1	0.3	0.7	-0.3	0.6	0.8	-0.2	0.3	0.6	0.0	-0.5	0.8
Number of full sisters	0.2	0.2	0.9	0.4	-0.2	-0.7	-0.1	0.4	0.5	0.9	-0.2	0.4
Suffer from ‘nerves’	0.3	0.4	1.7	0.5	-0.7	-0.2	0.5	0.7	0.3	0.7	-0.1	-1.3
Overall health rating	0.4	0.8	2.2	1.3	-0.7	-1.5	-0.1	0.6	0.7	1.2	-0.6	0.0
Chest pain or discomfort	0.7	1.0	2.3	1.2	-0.0	-0.2	0.2	1.2	1.4	1.5	-1.2	0.0
Had major operations	0.1	0.1	0.3	-0.3	-0.4	-0.1	0.2	0.6	0.3	-0.0	-0.3	-0.2
Age at last live birth	0.9	1.3	4.2	-0.7	1.9	2.0	1.1	0.5	0.5	0.7	-0.7	1.0
Family relationship satisfaction	0.7	0.9	3.6	0.6	-1.9	-1.5	-0.6	0.1	-0.0	-0.8	0.4	-0.8
Leg pain on walking	0.9	1.1	3.3	0.3	-1.0	-1.8	-0.8	-1.0	-1.0	-1.3	1.1	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.5	1.4	-1.0	-1.9	0.5	1.4	1.0	1.3	-0.8	-1.5
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.2	1.4	-1.8	-1.0	0.5	0.6	0.4	0.9	-0.8	-1.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.8	-1.3	1.7	1.6	-0.2	-0.8	-0.5	-0.4	0.5	1.5
Medication: Aspirin	0.6	0.7	1.2	-0.8	0.1	-0.9	-1.0	-1.1	-1.1	-0.8	1.1	0.2
Supplements: Vitamin C	1.2	1.4	4.6	-1.5	-0.4	0.2	-1.1	-1.0	-1.2	-2.1	1.4	-0.2
Knee pain experienced in last month	0.4	0.6	2.4	1.6	0.3	-0.1	0.5	0.2	0.5	1.2	-0.6	0.7
Hypertension (Self-reported)	0.5	1.4	3.6	-0.9	1.9	1.0	0.3	0.3	1.1	1.7	-1.1	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.2	-0.6	-0.7	-0.6	-1.5	-0.9	-0.8	-1.0	0.9	0.2
Illnesses of father: Heart disease	0.9	1.3	4.6	-1.3	0.6	-1.1	-2.1	-0.8	-0.8	-0.8	1.3	0.3
Illnesses of siblings: Diabetes	0.6	0.7	1.4	-0.3	0.9	1.1	0.3	0.7	1.2	0.3	-1.1	1.0
Smoking status: Previous	0.8	1.2	5.1	-0.5	-0.4	-0.5	0.0	-1.4	-2.3	-0.7	1.3	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	5.6	-1.4	1.9	2.4	0.8	-0.4	-0.5	0.6	0.2	1.1
Whole body fat-free mass	0.3	1.4	3.8	-1.3	1.7	1.7	-0.7	-0.1	0.7	0.6	-0.5	1.9
Leg fat-free mass (right)	0.3	1.6	3.9	-1.9	2.0	1.4	-1.0	-0.2	0.6	0.3	-0.4	1.9
Arm fat percentage (left)	0.4	1.5	3.0	-1.3	1.7	1.7	-1.0	0.2	1.2	0.8	-1.0	1.4
Average weekly red wine intake	0.7	1.0	2.4	0.4	-0.7	-1.2	-0.3	-0.8	-1.1	-1.5	1.3	-1.0
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.3	-0.7	0.5	0.3	1.1	-0.2	-0.4	0.6	-0.2	-0.2
Mood swings	0.3	0.6	1.5	1.0	0.1	0.6	0.3	1.0	1.2	0.4	-1.1	0.2
Loneliness, isolation	0.3	0.4	0.8	-0.2	-0.7	-0.9	-0.7	-0.4	-0.6	-0.8	0.8	0.1
Long-standing illness, disability or infirmity	0.5	0.8	2.4	0.9	-1.5	-1.0	-0.1	0.8	0.9	0.0	-0.6	-1.2
Ever had bowel cancer screening	0.5	0.6	1.7	0.2	-1.2	-1.3	-0.4	-0.2	-0.1	0.5	-0.0	-1.2
Diabetes diagnosed by doctor	0.1	0.1	0.4	-0.1	-0.4	0.3	0.7	0.1	-0.2	0.3	-0.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.4	-0.6	-0.0	0.3	0.5	0.2	0.2	0.6	-0.5	0.3
Friendships satisfaction	0.9	1.1	2.1	-0.3	-0.9	-1.4	-1.1	-1.1	-0.9	-1.5	1.1	-0.4
Qualifications: nursing, teaching	0.7	1.1	4.7	-0.5	1.0	2.2	0.8	0.5	0.7	0.1	-0.7	1.6
Commuting to job workplace: Walk	1.2	1.3	2.4	0.7	1.2	0.4	1.5	1.5	1.4	1.0	-1.2	0.7
Eye problems/disorders: Cataract	0.1	0.1	0.5	0.4	0.3	-0.4	-0.4	-0.1	-0.1	-0.3	-0.2	0.7
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	6.1	0.0	1.0	2.2	2.5	1.7	1.5	1.7	-2.1	1.7
Medication for cholesterol	0.2	0.3	1.7	0.3	-0.1	0.7	1.3	0.3	-0.4	-0.3	0.1	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	0.3	0.7	-0.3	-0.3	0.1	0.2	0.2	0.0	0.3
Back pain experienced in last month	0.9	1.3	3.0	1.7	-1.7	-1.3	0.8	0.6	0.2	1.1	-0.3	-1.3
Mineral and other dietary supplements	0.2	0.3	0.9	0.6	-0.4	-0.1	0.9	0.3	-0.2	0.9	-0.4	-0.4
Breast cancer (self-reported)	2.6	3.1	6.6	-1.5	-0.2	-1.8	-2.6	-1.7	-2.1	-2.0	2.1	-0.1
Asthma (self-reported)	1.4	2.8	6.5	1.4	-2.5	-2.3	-0.6	-0.2	-0.7	-1.5	1.3	-2.5
Osteoporosis (self-reported)	0.7	0.8	1.9	-0.0	0.5	1.4	0.5	1.2	1.3	0.5	-1.3	-0.2
Osteoarthritis (self-reported)	0.3	0.4	2.5	-0.3	-0.5	-1.6	0.1	0.1	-0.1	0.8	-0.2	-0.7
Medication: Aspirin	0.3	0.3	0.8	-0.8	0.3	-0.9	-0.3	-0.5	-0.7	-0.4	0.6	0.5
Medication: Gliclazide	0.6	0.6	1.3	-1.1	-1.1	0.1	-1.1	-0.2	-0.1	-0.6	0.6	-1.1
Illnesses of father: None of the above (group 1)	0.5	0.7	1.7	0.8	-1.3	-0.6	-0.1	-0.4	-0.5	-1.2	0.9	-0.9
Smoking status: Current	0.4	0.6	2.0	1.3	-1.4	-1.1	0.2	0.0	0.1	0.0	0.0	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.2	-0.1	0.3	1.6	2.1	1.7	1.8	2.3	-2.2	1.2
Whole body water mass	0.2	1.3	3.6	-1.2	1.6	1.7	-0.7	-0.1	0.6	0.4	-0.4	1.9
Leg predicted mass (right)	0.3	1.6	3.9	-1.9	2.0	1.4	-1.0	-0.2	0.6	0.3	-0.4	1.9
Arm fat mass (left)	0.5	1.9	3.8	-1.6	2.0	1.9	-1.4	-0.3	0.9	0.3	-0.6	1.9
Number of self-reported non-cancer illnesses	0.9	1.5	4.7	-1.7	1.5	-0.4	-2.2	-0.7	0.4	-0.1	0.2	1.7
Average weekly champagne plus white wine intake	0.8	1.1	5.4	0.3	-2.3	-1.0	0.5	0.2	-0.4	0.4	-0.1	-1.6
Miserableness	0.2	0.4	1.3	0.4	-1.1	-0.7	-0.2	0.3	0.4	-0.6	-0.3	-0.8
Guilty feelings	0.6	0.9	2.1	-0.7	1.4	-0.1	-1.4	-0.7	-0.6	-1.0	0.9	0.8
Wears glasses or contact lenses	1.2	1.4	3.5	-0.0	0.7	1.9	0.7	1.2	1.4	1.6	-1.5	0.3
Ever taken oral contraceptive pill	0.6	0.6	2.8	-0.9	-0.7	-0.0	-1.7	-0.8	-0.1	-0.8	0.5	-0.3
Hearing aid user	0.2	0.3	0.7	-0.8	0.0	-0.3	-0.6	-0.4	-0.3	-0.8	0.3	0.5
Mother’s age at death	0.4	0.5	0.9	0.0	0.8	-0.6	-0.7	-0.9	-1.0	-0.4	0.6	0.7
Financial situation satisfaction	0.6	0.8	4.5	0.2	-0.3	-2.1	-0.9	-0.5	-0.6	-0.2	0.9	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.6	0.2	0.4	1.3	0.1	0.4	0.2	0.2	-0.0	-0.2
Commuting to job workplace: Public transport	0.5	0.6	2.5	-0.6	-0.1	-0.1	-1.1	-0.2	-0.3	-1.6	0.9	-0.1
Eye problems/disorders: Glaucoma	1.5	1.8	3.5	-0.0	0.4	1.0	1.8	1.6	1.5	1.9	-1.7	0.9
Medication: Blood pressure	0.2	0.3	1.2	-0.1	0.4	0.4	0.0	0.3	1.1	0.7	-0.8	0.4
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	0.8	-1.3	-1.3	-0.0	0.7	0.8	-0.0	-0.2	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.9	-0.9	0.6	-0.3	-0.7	-0.4	-0.3	-0.4	0.4	0.9
High cholesterol (Self-reported)	0.3	0.5	1.4	-1.2	-1.1	-0.2	-0.7	-0.2	-0.5	-0.6	0.7	-0.7
Medication: Bendroflumethiazide	0.4	0.6	1.5	0.8	0.6	1.0	-0.2	0.5	1.2	0.3	-0.8	0.8
Medication: Paracetamol	0.9	1.5	2.9	-1.4	0.9	-0.6	-1.7	-1.4	-1.1	-1.4	1.4	0.5
Medication: Lisinopril	0.7	0.9	3.4	-1.8	1.2	0.2	-0.3	-0.9	-0.7	-0.1	0.5	1.2
Medication: Atorvastatin	1.7	2.0	6.7	0.8	-2.3	-2.1	-0.8	0.5	0.3	-0.3	0.0	-2.6
Illnesses of father: High blood pressure	1.9	2.4	3.4	-0.5	1.8	1.8	1.1	1.3	1.8	1.7	-1.8	1.6
Alcohol drinker status: Never	0.1	0.1	0.3	0.5	0.0	-0.2	0.2	0.2	-0.0	0.1	-0.4	0.4
Ever smoked	0.5	0.8	1.9	1.0	-1.4	-0.9	0.8	-0.5	-1.4	-0.4	0.4	-0.8
Basal metabolic rate	0.3	1.8	4.4	-1.5	1.9	2.0	-0.8	-0.1	0.8	0.6	-0.6	2.1
Leg fat percentage (left)	0.3	1.2	2.8	-0.9	1.0	1.2	-0.7	0.5	1.7	1.2	-1.2	1.1
Arm fat-free mass (left)	0.3	1.4	3.9	-1.4	1.5	1.8	-0.9	-0.4	0.5	0.1	-0.2	2.0
Number of operations (self-reported)	1.4	2.0	3.3	0.9	-1.6	-0.7	1.8	1.8	1.7	1.4	-1.7	-0.5
Average weekly beer plus cider intake	0.5	0.8	1.6	-0.6	1.2	0.3	-0.2	-1.1	-1.3	-0.1	1.0	1.2
Irritability	1.7	2.9	8.7	1.5	-2.7	-2.9	0.1	-0.1	-0.9	-1.4	0.8	-1.9
Risk taking	1.4	2.1	7.1	1.7	-2.4	-2.7	1.1	0.6	-0.1	-0.0	-0.1	-1.1
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.4	-0.5	-1.0	-0.5	-0.6	-0.7	-1.2	-0.5	0.8	-0.4
Fractured/broken bones in last 5 years	1.1	1.4	3.1	0.2	-1.2	-1.7	0.2	-1.2	-1.8	-0.8	1.2	-1.2
Age started oral contraceptive pill	1.6	2.0	6.7	-2.1	1.6	1.0	-0.3	-1.3	-0.9	-0.2	0.5	2.6
Diastolic blood pressure, automated reading	1.1	3.4	10.8	-1.6	3.3	1.2	-1.5	-1.4	-0.7	-1.2	0.9	2.9
Ever depressed for a whole week	1.1	1.4	2.9	-1.1	0.3	-0.4	-1.7	-1.2	-1.1	-1.7	1.4	0.9
Unable to work because of sickness or disability	1.7	2.2	3.5	1.9	-1.7	-0.9	0.5	1.8	1.6	1.3	-1.3	-1.6
Commuting to job workplace: Cycle	0.3	0.4	1.5	0.2	-0.2	0.4	1.2	0.8	0.3	0.7	-0.8	0.3
Myopia	0.2	0.3	1.2	-0.6	1.1	0.5	-0.3	-0.1	-0.2	-0.6	0.1	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.6	1.1	-1.6	-0.8	-0.2	-0.1	-1.0	-1.4	0.9	-0.9
Cholesterol lowering medication	0.4	0.6	1.9	-0.8	-0.6	-1.0	-1.4	-0.2	-0.3	-1.0	0.8	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.0	-0.8	0.1	-0.4	-1.0	-0.7	-0.7	-0.4	0.4	0.1
Pain experienced in last month	0.2	0.4	0.9	-0.4	-0.3	-0.9	-0.5	-0.5	-0.5	-0.8	0.5	-1.0
Supplements: Calcium	0.4	0.4	1.4	-0.4	0.7	1.2	0.4	0.5	0.8	-0.6	-0.4	0.6
Basal cell carcinoma (self-reported)	0.6	0.7	1.5	0.3	-0.9	-0.8	0.8	0.6	0.4	1.2	-0.9	-0.9
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.0	1.3	-2.0	-2.0	0.0	0.4	0.1	0.5	0.4	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.1	-2.0	0.6	-0.6	-1.3	-2.0	-2.0	-1.5	1.6	1.1
Heart disease (siblings)	1.5	1.8	4.3	-1.9	2.1	1.4	-1.6	-0.8	-0.0	-0.2	0.2	1.8
Alcohol drinker status: Previous	0.2	0.2	0.5	0.4	-0.2	0.0	0.7	0.4	0.5	0.4	-0.4	0.3
Pack years of smoking	0.9	1.3	3.9	0.6	-2.0	-1.8	-1.2	0.0	0.1	-0.5	0.4	-1.5
Impedance of whole body	0.1	0.6	1.1	0.9	-0.2	0.9	0.9	1.1	0.6	0.6	-0.6	-1.0
Leg fat mass (left)	0.5	1.9	3.2	-1.7	1.7	1.8	-1.2	0.1	1.3	0.8	-0.9	1.8
Arm predicted mass (left)	0.3	1.4	3.8	-1.4	1.4	1.7	-1.0	-0.3	0.7	0.1	-0.3	1.9