Hub : Genes

METTL22

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0936 0.0342 3.2e-03 -0.003 NA 0.011 NA 0.003 8.6e-01 NA 4.3e-02 NA 1.9e-01
2 GTEx Brain Cerebellar Hemisphere 0.3480 0.1090 4.8e-03 0.170 NA 0.130 NA 0.160 3.9e-05 NA 3.4e-04 NA 6.8e-05
3 GTEx Brain Cerebellum 0.7260 0.0790 1.4e-08 0.321 NA 0.325 NA 0.323 3.2e-10 NA 2.4e-10 NA 2.8e-10
4 GTEx Cells Transformed fibroblasts 0.1420 0.0430 3.1e-04 0.049 NA 0.149 NA 0.146 1.4e-04 NA 2.8e-11 NA 4.7e-11
5 GTEx Heart Left Ventricle 0.1617 0.0534 2.2e-03 0.139 NA 0.143 NA 0.143 7.6e-08 NA 4.9e-08 NA 5.1e-08
6 GTEx Muscle Skeletal 0.2063 0.0391 4.3e-09 0.166 NA 0.198 NA 0.196 4.7e-16 NA 3.7e-19 NA 5.9e-19
7 GTEx Skin Sun Exposed Lower leg 0.0990 0.0400 9.5e-03 0.004 NA -0.002 NA -0.001 1.3e-01 NA 5.9e-01 NA 4.0e-01
8 GTEx Testis 0.2880 0.0750 1.1e-03 0.240 NA 0.158 NA 0.216 5.2e-11 NA 1.6e-07 NA 6.2e-10
9 ROSMAP Brain Pre-frontal Cortex 0.0510 0.0198 5.7e-03 0.063 0.01 0.046 0.041 0.056 1.6e-08 0.017 1.1e-06 5.1e-06 9.0e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.2 0.3 1.1 -0.3 1.0 0.1 0.9 -0.1 -0.5 0.3 0.1 0.7
Bipolar Disorder or Schizophrenia 0.3 0.8 2.3 -1.5 1.2 0.1 -0.1 -0.5 -0.9 -0.7 0.5 1.1
Depressed Affect (Nagel 2018) 0.1 0.3 1.1 -0.0 -0.6 0.1 -0.8 -0.4 -0.0 -1.1 0.2 -0.1
Depression (Nagel 2018) 1.1 1.7 5.3 2.2 -1.7 -2.3 0.2 0.6 0.2 0.2 -0.3 -1.2
Intelligence (Savage-Jansen 2018) 0.4 1.3 4.4 0.1 -2.1 -1.7 -1.2 -0.6 -0.7 -0.8 1.0 -0.6
Neuroticism (Nagel 2018) 0.4 1.0 1.9 0.3 -1.4 -1.1 -1.2 -0.4 -0.3 -1.4 0.8 -1.4
Schizophrenia (2018) 0.4 0.8 2.6 -1.6 0.7 0.1 -0.9 -0.6 -0.8 -1.1 0.6 0.8
Schizophrenia vs Biploar Disorder 0.4 0.5 2.8 -0.7 0.6 1.7 -0.2 0.1 0.6 -0.1 -0.2 0.7
Worry (Nagel 2018) 0.6 1.3 3.5 0.6 -1.8 -1.4 -0.8 -0.2 -0.4 -1.0 0.8 -1.9
Alzheimer’s Disease (in mother) 0.8 0.9 1.6 -0.9 1.2 -0.1 -1.3 -1.1 -0.5 -1.0 0.8 1.0
Alzheimer’s Disease (in father) 1.7 1.8 4.0 -0.2 -0.9 0.6 1.4 1.4 1.5 1.9 -2.0 -1.0
Alzheimer’s Disease (including proxy) 0.3 0.5 1.4 -0.4 -0.1 0.3 0.2 0.6 1.1 1.0 -1.2 -0.3
Crohns Disease (2017) 1.3 2.8 7.0 0.7 -0.1 0.6 1.0 2.5 2.6 2.4 -1.9 -0.3
Irritable Bowel Disease (IBD) 0.2 0.4 1.2 -1.1 0.8 0.8 -0.3 -0.0 -0.0 0.1 0.5 0.8
Ulcerative Colitis (UC) 1.5 2.8 4.7 -2.2 1.3 0.8 -1.0 -1.9 -2.1 -1.6 2.1 1.4
Major Depression (MDD) 0.2 0.2 0.5 0.6 -0.6 -0.6 0.7 0.4 0.2 0.2 -0.1 -0.5
Reaction Time 0.3 0.7 1.8 0.6 -1.3 -1.0 0.4 0.4 0.3 0.7 -0.2 -1.3
Verbal and Numeric Reasoning (VNR) 0.4 1.0 4.4 0.3 -2.1 -1.4 -0.1 0.1 -0.5 -0.8 0.6 -1.2
Breast Cancer 1.0 2.3 7.8 1.0 -2.7 -1.2 1.1 1.2 0.5 0.5 -0.4 -2.8
Ovarian Cancer 1.7 2.2 7.6 0.5 -1.8 -2.3 -1.2 0.9 0.6 0.9 -0.2 -2.8
Prostate Cancer 0.1 0.1 0.6 0.4 -0.1 -0.3 0.8 0.0 -0.1 0.3 -0.2 -0.0
Age at First Birth 0.5 0.8 2.0 -0.8 0.9 1.4 -0.2 0.5 1.1 0.9 -1.0 0.6
Bipolar Disorder (2011) 0.5 0.4 1.2 0.8 -0.4 -1.1 0.8 0.0 -0.5 0.6 -0.1 -0.8
Body Mass Index (BMI) (2010) 0.3 0.4 1.4 -0.4 0.5 1.2 0.7 -0.0 0.2 0.7 0.2 1.0
Coronary Artery Disease (CAD) 1.4 1.7 3.2 1.7 -1.4 -0.6 1.2 1.1 0.9 1.8 -1.1 -1.4
Crohns Disease (2012) 0.2 0.3 1.2 -0.3 1.0 1.1 0.1 0.2 0.3 0.3 -0.0 0.4
Mean Putamen Volume 0.5 0.6 1.2 1.0 -0.7 0.2 0.4 1.0 1.1 0.7 -0.8 -0.7
Fasting Glucose 0.4 0.4 1.7 0.1 -0.2 -0.3 1.3 -0.3 -1.0 -0.3 0.9 -0.6
HbA1C 2.2 2.5 5.5 2.4 -0.6 -0.4 1.4 1.9 1.7 2.0 -1.6 -1.1
HDL Cholesterol 0.2 0.3 0.9 0.6 -0.1 -0.2 -0.0 0.6 0.9 0.9 -0.7 0.0
LDL Cholesterol 0.3 0.5 1.1 -0.4 -0.1 -0.1 -1.0 -1.0 -0.6 -0.7 1.0 0.2
Lupus 1.6 2.4 4.9 -1.7 -0.5 -0.3 -2.2 -1.9 -1.3 -2.1 1.9 -0.5
Neuroticism (2016) 0.3 0.4 0.9 -0.2 -0.8 -0.4 -0.9 -0.6 -0.1 -0.9 0.6 -0.5
Primary Biliary Cirrhosis 0.2 0.3 1.4 1.2 -0.3 0.2 0.8 0.3 0.4 -0.1 -0.6 -0.0
Rheumatoid Arthritis 0.6 0.8 2.4 -0.3 -1.5 -0.3 -0.5 -0.5 -0.8 -1.0 1.1 -1.1
Schizophrenia (2014) 1.0 2.3 4.9 -1.9 1.2 -0.1 -1.2 -1.5 -1.8 -2.2 1.7 0.9
Triglycerides 0.3 0.4 1.9 0.1 0.1 1.1 1.4 0.2 0.1 0.3 -0.3 0.5
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.0 0.6 -0.3 0.6 0.1 0.7 1.0 0.7 -0.6 0.6
Ulcerative Colitis 4.0 5.8 9.4 -2.8 1.9 1.1 -1.8 -3.0 -3.1 -2.5 2.9 2.0
Blood Eosinophil Count 0.1 0.5 2.2 -0.3 -0.8 0.1 0.5 0.5 0.5 1.5 -0.6 -0.8
Blood Platelet Count 0.1 0.7 2.0 -0.6 1.2 1.4 -1.4 -0.3 0.1 -0.4 0.4 0.8
Blood Red Count 0.1 0.9 3.4 -0.4 -0.1 0.7 0.0 1.2 1.9 1.1 -1.2 0.3
Blood White Count 0.2 1.5 2.9 -0.1 0.1 1.3 0.9 1.4 1.7 1.6 -1.7 0.3
Heel T-Score 0.1 0.5 1.4 1.2 -0.7 0.1 0.5 0.2 0.4 1.1 -0.6 -0.6
BMI 0.2 1.3 3.0 -1.7 1.4 1.1 -1.5 -0.9 -0.1 -0.3 0.2 1.4
Height 0.2 3.9 12.4 -1.6 2.9 3.5 1.1 0.3 -0.1 1.0 -0.2 3.1
Waist Hip Ratio (WHR) 0.8 3.5 12.1 -2.3 3.1 1.9 0.3 -0.4 0.0 0.4 -0.3 3.5
Systolic Blood Pressure 0.3 1.3 2.3 0.4 1.2 1.4 1.3 1.0 1.1 1.4 -1.5 0.2
Smoking Status 0.3 0.7 1.8 1.0 -1.4 -0.8 0.7 -0.2 -0.8 0.6 0.2 -0.9
Allergy or Eczema 0.3 0.7 1.3 0.4 0.9 -0.5 -0.5 -1.1 -0.9 -1.1 0.8 1.0
Cardiovascular Disease 0.2 0.6 1.9 -1.4 1.1 0.7 -0.9 -0.6 0.3 0.3 -0.2 0.4
Hypothyroidism (self reported) 0.5 1.0 3.3 -1.3 1.4 0.8 -0.6 -0.3 0.6 0.6 -0.7 1.8
Respiratory disease 1.1 2.5 7.4 0.9 -2.1 -2.7 -0.4 -0.5 -1.1 -1.5 1.5 -1.9
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.3 -0.0 -0.3 1.1 0.8 0.6 0.7 0.6 -0.9 -0.1
Lung FEV1/FVC ratio 0.3 1.5 4.1 1.4 -2.0 -2.0 -0.6 0.4 0.1 0.0 0.6 -1.7
Lung FVC 2.2 11.0 32.0 -2.5 4.1 5.7 2.0 0.7 1.3 1.9 -2.0 5.5
Neuroticism 0.1 0.3 0.9 0.4 -0.8 -0.3 -0.4 0.2 0.5 -0.4 -0.2 -1.0
Chronotype (morning person) 2.8 6.5 11.9 -3.5 3.3 1.0 -2.2 -2.9 -2.3 -1.9 2.4 2.6
Hair Pigment 0.0 0.3 0.5 -0.6 0.6 -0.7 -0.6 -0.6 -0.6 -0.1 0.6 0.2
Tanning 0.0 0.3 0.6 -0.6 -0.5 0.4 -0.3 -0.4 -0.4 -0.7 0.4 -0.8
Hand grip strength (left) 0.8 2.0 6.5 -1.3 2.3 1.3 0.4 -1.1 -1.1 0.5 0.4 2.5
Number of treatments/medications taken 0.6 1.1 3.4 -1.5 1.9 -0.5 -0.6 -0.1 0.4 0.7 -0.5 1.7
Average weekly spirits intake 1.1 1.4 4.8 1.1 -1.7 -1.4 -0.8 0.7 0.7 -0.0 -0.1 -2.2
Sensitivity / hurt feelings 0.2 0.4 2.2 -0.9 0.3 0.1 -1.5 -0.1 0.6 -0.5 0.2 0.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 3.5 1.3 -1.1 -1.9 0.6 0.6 -0.1 0.4 -0.3 -0.6
Hearing difficulty/problems: Yes 0.4 0.7 2.9 -0.5 -0.1 1.1 -1.7 -0.1 1.0 -0.7 -0.1 0.3
Relative age of first facial hair 0.1 0.2 0.7 -0.5 -0.2 -0.1 -0.9 0.0 0.3 -0.3 0.0 -0.4
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 5.2 0.6 -0.9 -1.2 0.4 2.3 2.2 1.9 -1.8 -0.8
Ever used hormone-replacement therapy (HRT) 0.4 0.5 1.8 -0.4 -0.4 0.3 -0.4 0.7 1.3 0.9 -1.0 -0.0
Ever had hysterectomy (womb removed) 0.5 0.6 2.4 -1.6 0.2 -0.4 -0.7 -0.4 -0.7 -0.9 0.6 0.6
Systolic blood pressure, automated reading 0.6 1.6 4.4 -1.3 2.1 0.8 -1.2 -1.4 -0.9 -1.1 1.1 1.2
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.1 -1.7 1.6 0.9 0.3 -0.8 -1.1 -0.2 0.5 1.8
Angina 0.2 0.3 1.1 -0.7 1.1 0.5 -0.4 -0.5 -0.3 -0.2 0.4 0.4
Medication for hormone replacement therapy 1.9 2.2 5.7 1.5 -0.5 0.0 1.4 1.7 1.5 2.4 -2.1 0.2
Vitamin and mineral supplements 0.2 0.3 1.9 -0.2 -0.9 -0.3 -0.1 -0.1 -0.4 -0.1 0.3 -1.4
Supplements: Zinc 0.3 0.3 1.2 -0.0 0.5 -0.6 -0.7 -0.0 0.5 -0.3 -0.3 1.1
Medication: Co-codamol 0.1 0.2 0.3 -0.1 0.5 -0.3 -0.6 -0.4 -0.5 -0.2 0.4 0.4
Medication: Metformin 0.3 0.4 1.6 -1.1 -0.0 1.3 -0.3 -0.4 -0.3 -0.1 0.2 0.2
Diabetes (father) 0.9 1.2 4.2 -2.0 1.0 0.3 -0.8 -0.6 -0.5 -1.3 0.4 1.5
Diabetes (mother) 0.7 0.9 1.8 -0.6 1.3 1.4 0.4 0.8 0.9 0.9 -1.0 1.0
Severe depression (siblings) 0.1 0.1 0.3 0.5 -0.3 0.3 -0.0 0.1 -0.2 -0.5 0.2 -0.4
Pack years adult smoking proportion 0.7 1.1 4.0 0.6 -2.0 -1.6 -0.7 0.5 0.6 -0.0 0.0 -1.5
Impedance of leg (right) 0.3 1.3 2.2 1.4 -1.0 0.8 1.5 1.4 0.9 1.1 -1.1 -1.1
Leg fat-free mass (left) 0.3 1.7 4.0 -1.6 2.0 1.7 -0.8 -0.0 0.7 0.4 -0.5 2.0
Trunk fat percentage 0.4 1.7 3.2 -1.3 1.7 1.8 -1.3 0.3 1.5 0.7 -1.0 1.4
Hand grip strength (right) 1.2 3.2 9.1 -1.6 2.7 3.0 1.0 -0.2 -0.1 1.3 -0.6 2.6
Townsend deprivation index at recruitment 0.6 0.8 2.7 -1.1 1.1 1.0 -0.7 0.1 0.6 -0.1 -0.0 1.6
Current tobacco smoking 0.3 0.5 2.0 1.1 -1.4 -1.1 0.1 -0.1 -0.1 -0.1 0.1 -0.0
Average weekly fortified wine intake 1.2 1.4 4.3 0.8 -1.5 -2.1 -1.1 0.2 -0.1 -0.7 0.7 -1.7
Maternal smoking around birth 0.3 0.5 2.1 0.2 -1.1 -0.9 0.2 0.4 0.4 0.3 -0.0 -1.5
Fed-up feelings 0.6 1.1 2.8 -0.8 1.3 0.6 -1.2 -0.8 -0.3 -1.3 0.8 1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.5 1.8 -1.3 -1.9 0.2 0.9 0.7 0.8 -0.8 -0.6
Relative age voice broke 0.4 0.6 1.6 -0.9 -0.7 -0.4 -1.2 -0.3 0.0 -1.3 0.6 -0.6
Taking other prescription medications 0.4 0.6 1.4 -0.7 0.5 -0.0 0.2 0.7 0.9 0.9 -1.2 1.1
Age when periods started (menarche) 0.6 1.3 3.5 -1.9 1.4 1.6 -0.1 -0.8 -1.2 0.3 0.8 1.1
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.8 -0.7 -0.8 -1.4 -1.7 -0.6 -0.3 -1.4 0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 2.3 0.6 0.2 0.7 0.2 1.0 1.4 1.5 -1.3 -0.4
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.9 -0.7 0.5 0.0 -0.7 -0.6 -0.3 -0.4 0.5 0.9
Qualifications: CSEs or equivalent 0.4 0.5 2.0 -0.6 0.5 -0.2 -0.1 -0.9 -1.4 -0.5 1.0 -0.4
Serious illness, injury or assault to yourself 1.3 1.6 4.5 1.6 -1.7 -2.1 0.4 1.0 0.4 -0.3 -0.0 -1.8
High blood pressure 0.4 1.1 3.2 -1.5 1.8 1.0 -0.1 -0.2 0.5 1.1 -0.6 1.2
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.7 0.5 1.1 0.1 0.0 -0.5 -0.5 -0.9 0.5 1.3
Multivitamins +/- minerals 1.1 1.4 4.7 0.7 1.4 0.8 0.4 0.7 1.4 0.8 -1.2 2.2
Stomach or abdominal pain in last month 0.2 0.2 0.5 -0.0 -0.7 0.4 -0.5 0.5 0.7 -0.3 -0.3 -0.2
Supplements: Glucosamine 0.2 0.3 0.8 0.6 0.4 0.1 0.4 0.6 0.9 0.3 -0.7 0.6
Diverticular disease/diverticulitis (self-reported) 1.0 1.1 3.4 -1.5 1.7 1.9 0.1 -0.1 0.1 0.3 -0.5 1.0
Medication: Atenolol 0.8 1.0 2.0 0.4 0.2 1.0 1.0 1.0 1.2 1.4 -1.3 0.3
Medication: Levothyroxine sodium 0.3 0.5 2.2 -0.9 0.4 -0.1 -1.5 -0.7 0.1 0.3 0.3 0.3
Sitting height 0.1 0.8 4.0 0.7 0.2 2.0 0.2 0.8 1.0 0.4 -0.7 0.1
Chronic bronchitis/emphysema (father) 0.1 0.1 0.2 0.4 -0.3 0.4 0.2 0.5 0.2 0.1 -0.3 -0.1
High blood pressure (mother) 0.3 0.4 2.4 0.3 0.2 -1.5 -0.5 0.1 0.5 0.5 0.1 0.4
Body mass index (BMI) 0.3 1.1 2.2 -1.5 1.2 1.1 -1.2 -0.2 0.9 0.4 -0.6 1.5
Impedance of leg (left) 0.2 1.1 1.7 0.9 -0.7 1.0 1.2 1.3 1.1 1.3 -1.1 -0.9
Leg predicted mass (left) 0.3 1.7 4.0 -1.6 2.0 1.7 -0.8 0.1 0.8 0.5 -0.6 2.0
Trunk fat mass 0.5 2.0 4.0 -1.3 1.9 2.0 -1.2 0.4 1.6 0.9 -1.1 1.7
Waist circumference 1.1 3.9 10.6 -2.5 3.0 2.5 -1.2 -0.4 0.9 0.5 -0.6 3.2
Number of incorrect matches in round 0.0 0.0 0.2 0.1 -0.0 0.3 0.1 0.2 0.5 -0.1 -0.2 0.1
Past tobacco smoking 0.8 1.4 4.1 -0.6 1.3 1.5 -0.2 1.2 2.0 0.8 -1.1 1.1
Alcohol usually taken with meals 0.0 0.1 0.2 0.1 0.2 0.1 -0.3 -0.4 0.0 0.2 0.1 0.3
Nervous feelings 0.6 1.1 4.6 0.9 -1.7 -0.9 -0.2 0.4 -0.0 0.3 0.3 -2.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 -0.7 0.9 0.2 -0.0 -0.1 -0.4 -0.2 0.3 1.0
Hearing difficulty/problems with background noise 0.6 0.9 2.0 -1.3 0.9 0.3 -1.1 -1.0 -0.5 -0.7 0.7 1.4
Hair/balding pattern: Pattern 2 0.2 0.2 0.7 -0.1 -0.2 -0.5 0.8 0.3 -0.3 0.4 0.3 -0.7
Had menopause 0.7 0.9 1.7 -1.1 0.8 0.3 -1.1 -1.3 -0.8 -0.8 1.2 0.6
Had other major operations 0.3 0.4 1.1 0.7 -0.7 -1.1 0.2 0.6 0.8 0.2 -0.1 -0.5
Forced vital capacity (FVC) 1.8 6.8 20.6 -2.4 3.6 4.5 1.4 -0.4 -0.3 0.8 -0.7 4.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.1 0.1 0.1 0.8 -0.5 0.4 1.1 0.7 -0.8 0.1
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 6.2 -1.5 1.1 -0.6 -0.7 -1.7 -1.5 -1.7 1.5 2.5
Qualifications: None of the above 0.2 0.4 1.6 0.1 0.1 1.3 -0.9 0.0 0.9 0.7 -0.1 0.5
Financial difficulties in last 2 years 0.1 0.1 0.6 -0.8 0.2 -0.6 0.0 0.5 0.0 0.0 0.2 -0.1
Mouth/teeth dental problems 1.6 2.4 4.9 -2.0 2.1 0.6 -2.2 -1.7 -0.8 -1.0 1.2 1.2
Heart attack 1.1 1.4 4.6 1.1 -1.9 -2.1 -0.4 -0.0 -0.3 -0.0 0.8 -1.5
Allergy 0.4 0.8 1.9 -1.1 0.7 1.4 0.2 0.6 0.9 1.1 -1.0 0.6
Pain all over the body in last month 1.3 1.4 3.0 -0.0 0.7 0.3 0.8 1.4 1.6 1.4 -1.7 1.3
Diabetes (self-reported) 0.1 0.1 0.5 -0.0 0.1 0.4 0.7 0.4 0.2 0.4 -0.5 0.2
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 6.3 -0.6 0.3 -1.2 -1.5 -1.7 -1.4 -2.5 1.7 0.9
Medication: Ramipril 0.3 0.4 1.9 0.4 0.1 -0.2 1.4 0.5 0.1 1.1 -0.5 0.3
Medication: Simvastatin 0.1 0.2 0.3 -0.5 0.4 0.6 0.1 -0.4 -0.5 0.1 0.3 0.5
Fluid intelligence score 1.8 3.7 7.9 -0.2 -2.7 -2.8 -1.8 -0.8 -1.4 -2.0 1.9 -2.2
Illnesses of siblings 0.6 0.8 2.7 0.8 -1.5 -0.3 0.6 -0.3 -1.0 -0.0 0.7 -1.6
Neuroticism score 0.1 0.3 0.8 -0.1 -0.6 -0.7 -0.6 0.1 -0.0 -0.9 0.3 -0.5
Weight 0.5 2.3 5.4 -1.7 2.1 2.3 -0.9 -0.1 0.9 0.6 -0.7 2.3
Impedance of arm (right) 0.2 0.8 2.5 0.8 0.9 1.6 1.0 1.0 0.6 0.5 -0.7 -0.1
Arm fat percentage (right) 0.5 2.1 4.7 -1.3 2.2 2.1 -0.6 0.4 1.4 1.0 -1.2 1.8
Trunk fat-free mass 0.2 1.2 3.5 -0.8 1.5 1.8 -0.3 -0.0 0.6 0.7 -0.6 1.9
Hip circumference 0.4 1.7 3.9 -1.6 1.8 2.0 -1.1 -0.2 0.8 0.3 -0.5 1.8
Time employed in main current job 0.2 0.2 0.5 0.2 0.7 0.4 0.4 -0.6 -0.1 0.3 -0.4 0.5
Alcohol intake versus 10 years previously 1.3 1.9 3.8 1.0 -1.2 -0.5 0.4 1.9 1.9 1.6 -1.5 -1.4
Father’s age at death 1.7 2.3 5.7 -2.0 2.4 0.6 -1.3 -1.4 -0.7 -0.6 1.0 2.4
Worrier / anxious feelings 0.1 0.2 0.6 -0.5 -0.1 -0.5 -0.8 0.1 -0.0 -0.4 0.5 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.9 0.1 0.4 0.3 -0.9 1.3 1.7 1.0 -0.9 0.6
Falls in the last year 0.8 1.0 2.4 1.2 -1.3 -1.5 1.0 0.8 0.3 0.7 -0.3 -1.2
Hair/balding pattern: Pattern 3 0.3 0.4 0.6 -0.8 0.6 0.4 -0.8 -0.5 -0.6 -0.5 0.6 0.7
Number of live births 0.2 0.3 1.0 -1.0 0.0 -0.1 -0.3 -0.9 -0.8 0.3 0.5 0.3
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 10.4 -1.7 2.3 3.2 1.7 0.3 0.0 1.0 -0.8 3.2
Pulse rate 0.7 1.1 2.6 0.0 0.5 -0.3 -0.8 -1.4 -1.6 -1.6 1.4 0.1
Happiness 0.4 0.5 1.5 0.4 -1.1 -1.2 -0.3 -0.3 -0.6 -0.3 0.4 -0.9
Noisy workplace 0.4 0.5 1.6 0.4 0.9 -0.9 0.5 -0.1 0.0 1.3 -0.3 0.8
Qualifications: A levels/AS levels or equivalent 0.6 1.4 4.5 -0.7 1.5 2.1 0.9 0.3 0.3 -0.2 -0.9 1.8
Serious illness, injury or assault of a close relative in last 2 years 3.4 3.9 10.0 3.2 -2.7 -1.6 0.7 1.6 1.4 1.2 -1.2 -2.7
Mouth/teeth dental problems: Dentures 2.6 4.4 12.8 2.5 -3.6 -3.3 0.7 0.4 -0.3 -0.0 0.2 -3.0
Asthma 1.3 2.6 6.0 1.5 -2.4 -2.2 -0.5 -0.2 -0.8 -1.4 1.3 -2.4
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 2.6 -0.7 1.6 0.6 0.5 1.1 1.2 0.9 -1.2 1.3
Medication: Cholesterol lowering 0.2 0.3 0.8 -0.2 -0.1 0.0 -0.4 -0.8 -0.9 -0.1 0.7 -0.4
Depression (self-reported) 0.7 0.8 3.1 -1.8 1.0 -0.3 -1.5 -0.6 -0.1 -0.3 0.2 0.8
Medication: Lansoprazole 0.2 0.2 0.8 -0.1 -0.9 -0.8 -0.2 -0.1 -0.0 -0.1 -0.1 -0.4
Prospective memory result 1.7 2.1 6.2 0.1 1.1 2.5 0.7 1.2 1.9 1.4 -1.7 1.0
Lung cancer (father) 0.7 0.8 1.9 1.0 -1.4 0.7 -0.1 1.0 1.4 -0.0 -0.7 -0.5
Illnesses of mother 0.4 0.5 1.7 -0.5 -1.3 0.7 0.4 -0.2 -0.6 -0.5 0.1 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.7 16.4 -2.0 2.7 4.0 2.1 0.9 0.8 1.5 -1.3 3.8
Pulse wave Arterial Stiffness index 0.4 0.5 1.3 0.4 -0.4 -1.1 -0.8 -0.4 -0.3 -0.9 0.8 -0.6
Impedance of arm (left) 0.1 0.4 0.9 0.8 0.2 1.0 0.7 0.8 0.2 0.4 -0.4 -0.8
Arm fat mass (right) 0.6 2.5 5.3 -1.7 2.3 2.3 -1.1 -0.0 1.1 0.6 -0.9 2.3
Trunk predicted mass 0.2 1.2 3.3 -0.7 1.4 1.8 -0.2 0.1 0.7 0.8 -0.7 1.8
Standing height 0.2 1.9 7.5 -0.4 2.0 2.7 0.6 0.4 0.5 1.0 -0.7 1.9
Length of working week for main job 1.2 1.3 2.2 1.5 -1.4 0.1 0.8 1.4 1.1 0.8 -1.1 -1.5
Exposure to tobacco smoke at home 0.9 1.0 3.7 1.9 -1.5 0.0 1.2 0.6 0.6 0.4 -0.6 -0.8
Breastfed as a baby 0.7 0.9 3.1 1.1 -0.5 -1.8 -0.9 -0.5 -0.7 -0.2 0.8 -1.1
Tense / ‘highly strung’ 1.1 1.8 6.1 1.2 -2.0 -2.5 -0.5 -0.0 -0.5 -1.1 0.6 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 4.8 1.3 -2.2 -1.5 0.5 1.7 1.4 1.5 -1.3 -1.8
Hair/balding pattern: Pattern 4 0.9 2.2 6.4 -1.7 1.8 1.4 -1.5 -1.6 -0.3 -0.3 0.5 2.5
Birth weight of first child 0.1 0.1 0.5 -0.6 0.1 0.7 0.3 -0.1 -0.1 -0.2 0.2 0.4
Peak expiratory flow (PEF) 0.2 0.4 2.0 -0.8 -0.1 0.5 1.4 -0.0 -0.7 -0.1 0.3 0.3
Pulse wave reflection index 0.8 1.0 2.5 0.9 -1.0 -0.4 -0.2 1.5 1.6 0.0 -0.9 -1.1
Ever highly irritable/argumentative for 2 days 1.4 1.7 4.2 0.2 0.0 -2.0 -0.8 -1.1 -1.5 -1.9 1.7 0.1
Loud music exposure frequency 1.3 1.4 3.2 0.7 -0.2 0.1 1.2 1.5 1.8 1.6 -1.7 0.4
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 2.1 -1.1 0.9 0.3 -1.2 -1.5 -1.5 -1.2 1.2 0.7
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 3.1 -0.1 1.1 1.7 1.1 0.8 0.5 0.5 -0.7 1.7
Blood clot in the leg (DVT) 1.5 2.0 3.3 -1.8 0.6 -0.7 -1.2 -1.8 -1.8 -1.4 1.5 1.1
Medication: Paracetamol 0.3 0.6 1.6 -0.5 0.8 -0.1 -1.3 -0.7 -0.3 -0.8 0.8 0.8
Headache pain in last month 1.7 3.0 8.2 -0.8 2.7 2.9 0.8 0.6 0.6 1.3 -0.8 2.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.2 1.4 -0.2 -0.1 -0.4 -0.4 -0.1 -0.1 -1.2 0.4 0.5
Glaucoma (self-reported) 1.5 1.8 4.3 0.2 0.7 0.7 2.1 1.4 1.0 2.1 -1.5 1.1
Gout (self-reported) 0.6 0.8 2.8 0.2 -1.7 -0.8 -0.9 -0.2 -0.4 -0.4 0.6 -1.4
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.0 -1.1 1.3 0.4 -0.6 -0.2 0.5 0.9 -0.5 1.4
Medication: Amlodipine 2.3 3.2 7.3 1.2 -0.8 -0.7 1.6 2.1 2.3 2.7 -2.3 -1.1
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.2 0.4 -0.7 -1.5 -0.7 -0.1 -0.1 -0.6 0.4 -0.9
Birth weight 0.3 0.7 3.0 -1.7 0.9 0.6 -0.7 -0.7 -0.4 0.2 0.3 1.0
Chronic bronchitis/emphysema (mother) 2.2 2.6 5.0 1.9 -0.4 0.0 1.4 1.9 2.0 2.1 -2.2 0.3
High blood pressure (siblings) 0.5 0.7 2.9 0.1 0.6 -0.1 -0.0 1.0 1.7 0.4 -1.3 0.3
Forced vital capacity (FVC), Best measure 2.7 9.9 31.0 -2.3 3.9 5.6 2.5 0.7 0.9 2.0 -1.9 4.8
Body fat percentage 0.4 1.7 3.2 -1.3 1.7 1.8 -1.1 0.4 1.5 0.9 -1.1 1.4
Leg fat percentage (right) 0.3 1.0 2.2 -0.6 0.9 1.2 -0.6 0.4 1.5 1.0 -1.1 1.1
Arm fat-free mass (right) 0.2 0.9 2.4 -1.4 1.1 1.1 -1.0 -0.2 0.6 0.4 -0.3 1.5
Exposure to tobacco smoke outside home 0.7 0.9 2.6 1.5 -1.6 -0.2 1.0 0.3 -0.5 -1.0 0.4 -1.0
Comparative body size at age 10 0.2 0.6 1.4 -0.8 -0.5 -1.2 -0.8 0.3 0.9 -0.0 -0.5 -1.1
Number of full brothers 0.6 0.8 2.9 -1.7 0.5 0.2 -1.6 -0.7 -0.4 -0.4 0.8 0.1
Worry too long after embarrassment 0.6 1.0 3.5 -1.4 0.2 -0.2 -1.9 -1.0 -0.5 -1.1 0.9 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.6 -0.2 0.6 0.2 0.8 0.6 0.4 0.2 -0.8 1.3
Wheeze or whistling in the chest in last year 0.4 0.6 2.3 0.7 -1.5 -1.1 -0.5 -0.0 0.3 -0.6 0.3 -0.8
Number of children fathered 1.0 1.2 5.5 0.4 -1.4 -2.4 -0.4 -0.3 -0.2 -0.3 0.2 -1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 -0.2 0.6 0.6 1.2 1.1 0.6 0.7 -0.8 0.5
Age at first live birth 0.9 1.6 4.6 -1.0 1.6 2.1 1.5 1.1 0.6 0.7 -0.9 1.1
Pulse wave peak to peak time 0.6 0.7 1.6 -0.4 0.6 1.3 1.0 0.4 0.3 1.2 -0.9 0.9
Health satisfaction 1.6 2.1 6.6 1.6 -2.6 -1.5 0.4 1.4 1.2 0.5 -0.8 -1.7
Shortness of breath walking on level ground 0.4 0.5 1.3 0.7 -0.4 -0.9 0.2 0.8 0.5 1.2 -0.7 -0.2
Qualifications: College or University degree 0.2 0.6 1.7 -1.1 0.8 0.6 -0.1 -0.4 -0.2 -1.3 0.3 1.2
Eye problems/disorders: None of the above 0.6 0.7 1.6 -0.6 0.1 0.2 -0.9 -1.2 -1.1 -0.5 1.3 -0.6
Mouth/teeth dental problems: Loose teeth 1.5 1.8 5.1 1.6 -2.2 -1.6 0.6 -0.1 -1.2 -0.5 1.1 -1.8
Emphysema/chronic bronchitis 0.7 0.8 3.1 1.8 -1.0 -1.5 -0.1 0.3 0.4 0.1 -0.0 -0.2
Medication for pain relief, constipation, heartburn 0.7 1.1 2.8 1.3 -1.3 -0.0 1.7 1.0 0.7 0.8 -0.8 -1.1
Neck or shoulder pain in last month 0.1 0.2 0.4 0.0 0.5 0.5 0.6 0.4 0.2 0.2 -0.4 0.6
Medication: Blood pressure 0.7 1.2 3.6 0.7 -0.0 0.5 1.4 1.1 1.0 1.9 -1.3 -0.4
Angina (self-reported) 0.4 0.6 1.3 -0.8 1.1 0.3 -0.6 -0.9 -0.7 -0.7 0.8 0.5
Migraine (self-reported) 0.6 0.7 2.4 -1.6 0.9 1.5 0.4 0.1 -0.2 0.2 -0.1 1.0
Medication: Ibuprofen 0.8 0.9 3.2 -1.5 1.8 0.4 -0.2 0.2 0.3 0.4 -0.4 1.4
Medication: Allopurinol 0.1 0.1 0.3 0.2 -0.6 -0.1 -0.6 -0.0 0.1 -0.2 0.1 -0.3
Medication: Omeprazole 0.6 0.8 2.3 -0.8 -0.0 -0.7 -1.5 -0.9 -1.1 -0.7 0.9 -0.1
Medication: Seretide 50 evohaler 0.2 0.2 0.9 0.6 -0.6 -0.1 -0.5 0.1 -0.0 -0.2 0.1 -1.0
Mean time to correctly identify matches 0.3 0.7 2.2 0.7 -1.5 -1.2 -0.1 0.0 0.3 0.5 -0.0 -1.1
Heart disease (mother) 0.3 0.3 1.5 0.1 1.2 0.2 0.0 0.3 0.5 0.4 -0.2 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.6 -0.1 -0.5 -1.3 -1.0 -0.5 -0.5 -1.2 0.8 -0.8
Whole body fat mass 0.5 2.0 3.7 -1.5 1.9 1.9 -1.2 0.2 1.3 0.8 -1.0 1.8
Leg fat mass (right) 0.4 1.6 2.8 -1.5 1.6 1.6 -1.1 0.1 1.2 0.7 -0.9 1.7
Arm predicted mass (right) 0.2 0.8 1.9 -1.3 0.9 1.2 -1.0 -0.2 0.6 0.3 -0.3 1.4
Pulse rate, automated reading 0.5 1.7 5.1 0.2 2.3 1.6 -1.3 -0.5 0.6 -0.8 0.2 2.1
Alcohol intake frequency. 0.8 1.9 4.4 -0.4 0.6 1.0 0.7 1.8 2.1 1.8 -1.9 1.0
Comparative height size at age 10 0.1 0.3 0.7 -0.3 0.6 0.8 -0.2 0.3 0.6 0.0 -0.5 0.8
Number of full sisters 0.2 0.2 0.9 0.4 -0.2 -0.7 -0.1 0.4 0.5 0.9 -0.2 0.4
Suffer from ‘nerves’ 0.3 0.4 1.7 0.5 -0.7 -0.2 0.5 0.7 0.3 0.7 -0.1 -1.3
Overall health rating 0.4 0.8 2.2 1.3 -0.7 -1.5 -0.1 0.6 0.7 1.2 -0.6 0.0
Chest pain or discomfort 0.7 1.0 2.3 1.2 -0.0 -0.2 0.2 1.2 1.4 1.5 -1.2 0.0
Had major operations 0.1 0.1 0.3 -0.3 -0.4 -0.1 0.2 0.6 0.3 -0.0 -0.3 -0.2
Age at last live birth 0.9 1.3 4.2 -0.7 1.9 2.0 1.1 0.5 0.5 0.7 -0.7 1.0
Family relationship satisfaction 0.7 0.9 3.6 0.6 -1.9 -1.5 -0.6 0.1 -0.0 -0.8 0.4 -0.8
Leg pain on walking 0.9 1.1 3.3 0.3 -1.0 -1.8 -0.8 -1.0 -1.0 -1.3 1.1 -0.6
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 3.5 1.4 -1.0 -1.9 0.5 1.4 1.0 1.3 -0.8 -1.5
Commuting to job workplace: Car/motor vehicle 1.0 1.1 3.2 1.4 -1.8 -1.0 0.5 0.6 0.4 0.9 -0.8 -1.3
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 2.8 -1.3 1.7 1.6 -0.2 -0.8 -0.5 -0.4 0.5 1.5
Medication: Aspirin 0.6 0.7 1.2 -0.8 0.1 -0.9 -1.0 -1.1 -1.1 -0.8 1.1 0.2
Supplements: Vitamin C 1.2 1.4 4.6 -1.5 -0.4 0.2 -1.1 -1.0 -1.2 -2.1 1.4 -0.2
Knee pain experienced in last month 0.4 0.6 2.4 1.6 0.3 -0.1 0.5 0.2 0.5 1.2 -0.6 0.7
Hypertension (Self-reported) 0.5 1.4 3.6 -0.9 1.9 1.0 0.3 0.3 1.1 1.7 -1.1 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.2 -0.6 -0.7 -0.6 -1.5 -0.9 -0.8 -1.0 0.9 0.2
Illnesses of father: Heart disease 0.9 1.3 4.6 -1.3 0.6 -1.1 -2.1 -0.8 -0.8 -0.8 1.3 0.3
Illnesses of siblings: Diabetes 0.6 0.7 1.4 -0.3 0.9 1.1 0.3 0.7 1.2 0.3 -1.1 1.0
Smoking status: Previous 0.8 1.2 5.1 -0.5 -0.4 -0.5 0.0 -1.4 -2.3 -0.7 1.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.6 5.6 -1.4 1.9 2.4 0.8 -0.4 -0.5 0.6 0.2 1.1
Whole body fat-free mass 0.3 1.4 3.8 -1.3 1.7 1.7 -0.7 -0.1 0.7 0.6 -0.5 1.9
Leg fat-free mass (right) 0.3 1.6 3.9 -1.9 2.0 1.4 -1.0 -0.2 0.6 0.3 -0.4 1.9
Arm fat percentage (left) 0.4 1.5 3.0 -1.3 1.7 1.7 -1.0 0.2 1.2 0.8 -1.0 1.4
Average weekly red wine intake 0.7 1.0 2.4 0.4 -0.7 -1.2 -0.3 -0.8 -1.1 -1.5 1.3 -1.0
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.3 -0.7 0.5 0.3 1.1 -0.2 -0.4 0.6 -0.2 -0.2
Mood swings 0.3 0.6 1.5 1.0 0.1 0.6 0.3 1.0 1.2 0.4 -1.1 0.2
Loneliness, isolation 0.3 0.4 0.8 -0.2 -0.7 -0.9 -0.7 -0.4 -0.6 -0.8 0.8 0.1
Long-standing illness, disability or infirmity 0.5 0.8 2.4 0.9 -1.5 -1.0 -0.1 0.8 0.9 0.0 -0.6 -1.2
Ever had bowel cancer screening 0.5 0.6 1.7 0.2 -1.2 -1.3 -0.4 -0.2 -0.1 0.5 -0.0 -1.2
Diabetes diagnosed by doctor 0.1 0.1 0.4 -0.1 -0.4 0.3 0.7 0.1 -0.2 0.3 -0.2 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.2 0.4 -0.6 -0.0 0.3 0.5 0.2 0.2 0.6 -0.5 0.3
Friendships satisfaction 0.9 1.1 2.1 -0.3 -0.9 -1.4 -1.1 -1.1 -0.9 -1.5 1.1 -0.4
Qualifications: nursing, teaching 0.7 1.1 4.7 -0.5 1.0 2.2 0.8 0.5 0.7 0.1 -0.7 1.6
Commuting to job workplace: Walk 1.2 1.3 2.4 0.7 1.2 0.4 1.5 1.5 1.4 1.0 -1.2 0.7
Eye problems/disorders: Cataract 0.1 0.1 0.5 0.4 0.3 -0.4 -0.4 -0.1 -0.1 -0.3 -0.2 0.7
Mouth/teeth dental problems: Mouth ulcers 1.9 3.0 6.1 0.0 1.0 2.2 2.5 1.7 1.5 1.7 -2.1 1.7
Medication for cholesterol 0.2 0.3 1.7 0.3 -0.1 0.7 1.3 0.3 -0.4 -0.3 0.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.5 0.3 0.7 -0.3 -0.3 0.1 0.2 0.2 0.0 0.3
Back pain experienced in last month 0.9 1.3 3.0 1.7 -1.7 -1.3 0.8 0.6 0.2 1.1 -0.3 -1.3
Mineral and other dietary supplements 0.2 0.3 0.9 0.6 -0.4 -0.1 0.9 0.3 -0.2 0.9 -0.4 -0.4
Breast cancer (self-reported) 2.6 3.1 6.6 -1.5 -0.2 -1.8 -2.6 -1.7 -2.1 -2.0 2.1 -0.1
Asthma (self-reported) 1.4 2.8 6.5 1.4 -2.5 -2.3 -0.6 -0.2 -0.7 -1.5 1.3 -2.5
Osteoporosis (self-reported) 0.7 0.8 1.9 -0.0 0.5 1.4 0.5 1.2 1.3 0.5 -1.3 -0.2
Osteoarthritis (self-reported) 0.3 0.4 2.5 -0.3 -0.5 -1.6 0.1 0.1 -0.1 0.8 -0.2 -0.7
Medication: Aspirin 0.3 0.3 0.8 -0.8 0.3 -0.9 -0.3 -0.5 -0.7 -0.4 0.6 0.5
Medication: Gliclazide 0.6 0.6 1.3 -1.1 -1.1 0.1 -1.1 -0.2 -0.1 -0.6 0.6 -1.1
Illnesses of father: None of the above (group 1) 0.5 0.7 1.7 0.8 -1.3 -0.6 -0.1 -0.4 -0.5 -1.2 0.9 -0.9
Smoking status: Current 0.4 0.6 2.0 1.3 -1.4 -1.1 0.2 0.0 0.1 0.0 0.0 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.2 -0.1 0.3 1.6 2.1 1.7 1.8 2.3 -2.2 1.2
Whole body water mass 0.2 1.3 3.6 -1.2 1.6 1.7 -0.7 -0.1 0.6 0.4 -0.4 1.9
Leg predicted mass (right) 0.3 1.6 3.9 -1.9 2.0 1.4 -1.0 -0.2 0.6 0.3 -0.4 1.9
Arm fat mass (left) 0.5 1.9 3.8 -1.6 2.0 1.9 -1.4 -0.3 0.9 0.3 -0.6 1.9
Number of self-reported non-cancer illnesses 0.9 1.5 4.7 -1.7 1.5 -0.4 -2.2 -0.7 0.4 -0.1 0.2 1.7
Average weekly champagne plus white wine intake 0.8 1.1 5.4 0.3 -2.3 -1.0 0.5 0.2 -0.4 0.4 -0.1 -1.6
Miserableness 0.2 0.4 1.3 0.4 -1.1 -0.7 -0.2 0.3 0.4 -0.6 -0.3 -0.8
Guilty feelings 0.6 0.9 2.1 -0.7 1.4 -0.1 -1.4 -0.7 -0.6 -1.0 0.9 0.8
Wears glasses or contact lenses 1.2 1.4 3.5 -0.0 0.7 1.9 0.7 1.2 1.4 1.6 -1.5 0.3
Ever taken oral contraceptive pill 0.6 0.6 2.8 -0.9 -0.7 -0.0 -1.7 -0.8 -0.1 -0.8 0.5 -0.3
Hearing aid user 0.2 0.3 0.7 -0.8 0.0 -0.3 -0.6 -0.4 -0.3 -0.8 0.3 0.5
Mother’s age at death 0.4 0.5 0.9 0.0 0.8 -0.6 -0.7 -0.9 -1.0 -0.4 0.6 0.7
Financial situation satisfaction 0.6 0.8 4.5 0.2 -0.3 -2.1 -0.9 -0.5 -0.6 -0.2 0.9 0.3
Tinnitus: Yes, now most or all of the time 0.2 0.2 1.6 0.2 0.4 1.3 0.1 0.4 0.2 0.2 -0.0 -0.2
Commuting to job workplace: Public transport 0.5 0.6 2.5 -0.6 -0.1 -0.1 -1.1 -0.2 -0.3 -1.6 0.9 -0.1
Eye problems/disorders: Glaucoma 1.5 1.8 3.5 -0.0 0.4 1.0 1.8 1.6 1.5 1.9 -1.7 0.9
Medication: Blood pressure 0.2 0.3 1.2 -0.1 0.4 0.4 0.0 0.3 1.1 0.7 -0.8 0.4
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.8 0.8 -1.3 -1.3 -0.0 0.7 0.8 -0.0 -0.2 -0.5
Supplements: Fish oil (including cod liver oil) 0.3 0.3 0.9 -0.9 0.6 -0.3 -0.7 -0.4 -0.3 -0.4 0.4 0.9
High cholesterol (Self-reported) 0.3 0.5 1.4 -1.2 -1.1 -0.2 -0.7 -0.2 -0.5 -0.6 0.7 -0.7
Medication: Bendroflumethiazide 0.4 0.6 1.5 0.8 0.6 1.0 -0.2 0.5 1.2 0.3 -0.8 0.8
Medication: Paracetamol 0.9 1.5 2.9 -1.4 0.9 -0.6 -1.7 -1.4 -1.1 -1.4 1.4 0.5
Medication: Lisinopril 0.7 0.9 3.4 -1.8 1.2 0.2 -0.3 -0.9 -0.7 -0.1 0.5 1.2
Medication: Atorvastatin 1.7 2.0 6.7 0.8 -2.3 -2.1 -0.8 0.5 0.3 -0.3 0.0 -2.6
Illnesses of father: High blood pressure 1.9 2.4 3.4 -0.5 1.8 1.8 1.1 1.3 1.8 1.7 -1.8 1.6
Alcohol drinker status: Never 0.1 0.1 0.3 0.5 0.0 -0.2 0.2 0.2 -0.0 0.1 -0.4 0.4
Ever smoked 0.5 0.8 1.9 1.0 -1.4 -0.9 0.8 -0.5 -1.4 -0.4 0.4 -0.8
Basal metabolic rate 0.3 1.8 4.4 -1.5 1.9 2.0 -0.8 -0.1 0.8 0.6 -0.6 2.1
Leg fat percentage (left) 0.3 1.2 2.8 -0.9 1.0 1.2 -0.7 0.5 1.7 1.2 -1.2 1.1
Arm fat-free mass (left) 0.3 1.4 3.9 -1.4 1.5 1.8 -0.9 -0.4 0.5 0.1 -0.2 2.0
Number of operations (self-reported) 1.4 2.0 3.3 0.9 -1.6 -0.7 1.8 1.8 1.7 1.4 -1.7 -0.5
Average weekly beer plus cider intake 0.5 0.8 1.6 -0.6 1.2 0.3 -0.2 -1.1 -1.3 -0.1 1.0 1.2
Irritability 1.7 2.9 8.7 1.5 -2.7 -2.9 0.1 -0.1 -0.9 -1.4 0.8 -1.9
Risk taking 1.4 2.1 7.1 1.7 -2.4 -2.7 1.1 0.6 -0.1 -0.0 -0.1 -1.1
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.4 -0.5 -1.0 -0.5 -0.6 -0.7 -1.2 -0.5 0.8 -0.4
Fractured/broken bones in last 5 years 1.1 1.4 3.1 0.2 -1.2 -1.7 0.2 -1.2 -1.8 -0.8 1.2 -1.2
Age started oral contraceptive pill 1.6 2.0 6.7 -2.1 1.6 1.0 -0.3 -1.3 -0.9 -0.2 0.5 2.6
Diastolic blood pressure, automated reading 1.1 3.4 10.8 -1.6 3.3 1.2 -1.5 -1.4 -0.7 -1.2 0.9 2.9
Ever depressed for a whole week 1.1 1.4 2.9 -1.1 0.3 -0.4 -1.7 -1.2 -1.1 -1.7 1.4 0.9
Unable to work because of sickness or disability 1.7 2.2 3.5 1.9 -1.7 -0.9 0.5 1.8 1.6 1.3 -1.3 -1.6
Commuting to job workplace: Cycle 0.3 0.4 1.5 0.2 -0.2 0.4 1.2 0.8 0.3 0.7 -0.8 0.3
Myopia 0.2 0.3 1.2 -0.6 1.1 0.5 -0.3 -0.1 -0.2 -0.6 0.1 0.7
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.6 1.1 -1.6 -0.8 -0.2 -0.1 -1.0 -1.4 0.9 -0.9
Cholesterol lowering medication 0.4 0.6 1.9 -0.8 -0.6 -1.0 -1.4 -0.2 -0.3 -1.0 0.8 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 1.0 -0.8 0.1 -0.4 -1.0 -0.7 -0.7 -0.4 0.4 0.1
Pain experienced in last month 0.2 0.4 0.9 -0.4 -0.3 -0.9 -0.5 -0.5 -0.5 -0.8 0.5 -1.0
Supplements: Calcium 0.4 0.4 1.4 -0.4 0.7 1.2 0.4 0.5 0.8 -0.6 -0.4 0.6
Basal cell carcinoma (self-reported) 0.6 0.7 1.5 0.3 -0.9 -0.8 0.8 0.6 0.4 1.2 -0.9 -0.9
Heart attack/myocardial infarction (self-reported) 1.1 1.4 4.0 1.3 -2.0 -2.0 0.0 0.4 0.1 0.5 0.4 -1.6
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 4.1 -2.0 0.6 -0.6 -1.3 -2.0 -2.0 -1.5 1.6 1.1
Heart disease (siblings) 1.5 1.8 4.3 -1.9 2.1 1.4 -1.6 -0.8 -0.0 -0.2 0.2 1.8
Alcohol drinker status: Previous 0.2 0.2 0.5 0.4 -0.2 0.0 0.7 0.4 0.5 0.4 -0.4 0.3
Pack years of smoking 0.9 1.3 3.9 0.6 -2.0 -1.8 -1.2 0.0 0.1 -0.5 0.4 -1.5
Impedance of whole body 0.1 0.6 1.1 0.9 -0.2 0.9 0.9 1.1 0.6 0.6 -0.6 -1.0
Leg fat mass (left) 0.5 1.9 3.2 -1.7 1.7 1.8 -1.2 0.1 1.3 0.8 -0.9 1.8
Arm predicted mass (left) 0.3 1.4 3.8 -1.4 1.4 1.7 -1.0 -0.3 0.7 0.1 -0.3 1.9