Hub : Genes

MIPOL1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0650 0.0240 5.0e-04 0.046 0.013 0.040 0.033 0.041 2.6e-06 9.5e-03 1.1e-05 0.00006 7.9e-06
2 GTEx Adipose Subcutaneous 0.1360 0.0430 4.4e-05 0.003 NA 0.058 NA 0.035 1.8e-01 NA 1.7e-05 NA 7.1e-04
3 GTEx Esophagus Mucosa 0.1570 0.0680 2.2e-03 0.023 NA 0.053 NA 0.048 1.1e-02 NA 1.9e-04 NA 3.6e-04
4 GTEx Heart Atrial Appendage 0.2170 0.0930 5.4e-03 -0.006 NA 0.043 NA 0.000 7.8e-01 NA 5.0e-03 NA 3.1e-01
5 GTEx Pancreas 0.2530 0.0670 8.5e-07 0.190 NA 0.172 NA 0.168 1.8e-08 NA 9.7e-08 NA 1.4e-07
6 GTEx Thyroid 0.1080 0.0410 1.4e-03 0.003 NA 0.002 NA 0.005 1.7e-01 NA 2.1e-01 NA 1.2e-01
7 NTR Blood 0.0208 0.0099 7.7e-03 0.001 0.003 0.000 0.005 0.001 1.8e-01 3.4e-02 3.7e-01 0.00590 1.0e-01
8 TCGA Thyroid Carcinoma 0.0500 0.0230 3.0e-06 0.072 0.059 0.056 NA 0.067 1.7e-07 2.0e-06 3.9e-06 NA 4.7e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.7 2.7 6.2 -0.1 -0.9 -0.8 -2.5 2.4 -1.7 -0.8 -2.2
Bipolar Disorder or Schizophrenia 0.4 1.0 3.4 -0.4 -0.3 -0.5 -0.5 1.8 -1.4 -0.2 -1.3
Depressed Affect (Nagel 2018) 0.6 1.3 4.5 -0.7 0.0 0.1 -1.6 1.6 -2.1 0.2 -0.4
Depression (Nagel 2018) 2.1 3.1 7.2 0.0 -1.4 -1.4 -2.4 2.1 -2.7 0.6 -1.9
Intelligence (Savage-Jansen 2018) 1.6 5.0 9.6 -0.2 -2.1 -2.3 -2.7 2.2 -1.5 2.6 -3.1
Neuroticism (Nagel 2018) 0.3 0.6 4.2 0.2 0.3 -0.1 -2.0 0.3 -0.6 -0.1 0.3
Schizophrenia (2018) 0.1 0.3 1.1 -0.4 0.4 -0.0 1.0 0.7 -0.4 0.3 0.1
Schizophrenia vs Biploar Disorder 0.5 0.6 1.8 0.0 0.2 -0.2 1.1 -0.8 -0.9 1.4 0.9
Worry (Nagel 2018) 0.3 0.6 1.5 1.2 0.6 -0.3 -0.3 -0.3 0.6 -1.1 0.9
Alzheimer’s Disease (in mother) 0.9 1.0 3.4 0.9 0.4 -1.9 -1.5 0.6 -0.9 -0.7 0.2
Alzheimer’s Disease (in father) 1.0 1.1 3.0 0.4 1.0 0.2 1.4 -0.9 1.7 -0.9 0.9
Alzheimer’s Disease (including proxy) 0.8 1.1 2.9 1.2 0.7 -1.5 -0.9 -0.2 0.0 -1.7 0.9
Crohns Disease (2017) 0.7 1.6 4.4 0.8 -1.0 -1.2 0.6 2.1 -1.3 0.5 -1.7
Irritable Bowel Disease (IBD) 0.4 1.0 2.1 1.1 -1.0 -1.3 0.2 1.4 -0.6 -0.3 -1.1
Ulcerative Colitis (UC) 0.2 0.4 1.3 0.8 -0.0 -0.5 -0.0 -0.3 0.8 -1.2 0.3
Major Depression (MDD) 0.8 1.0 1.9 -0.6 -1.3 -1.0 -0.8 1.4 -0.9 0.2 -1.3
Reaction Time 1.3 2.5 6.3 1.2 0.8 -0.2 2.5 -2.3 1.8 0.5 1.7
Verbal and Numeric Reasoning (VNR) 0.9 2.2 7.6 -0.7 -1.0 -0.4 -1.8 1.4 -0.4 2.7 -1.8
Breast Cancer 0.3 0.7 2.2 -1.5 0.9 0.9 -0.0 -0.3 0.3 1.2 -0.3
Ovarian Cancer 0.8 1.1 1.9 1.0 -1.2 -1.1 -0.7 1.1 -0.9 -1.4 -0.9
Prostate Cancer 5.7 8.0 18.9 1.1 -2.7 -3.0 -2.7 4.3 -2.4 -1.4 -3.5
Age at First Birth 0.2 0.3 1.5 -0.4 0.1 -0.8 0.4 0.5 0.2 1.2 -0.2
Bipolar Disorder (2011) 1.0 0.9 2.4 -1.6 1.1 0.8 0.0 0.1 -1.5 1.0 -0.2
Body Mass Index (BMI) (2010) 0.6 0.9 3.0 0.5 -0.2 -0.9 -0.9 -0.3 -1.4 1.7 -0.4
Coronary Artery Disease (CAD) 0.9 1.1 2.8 -1.6 1.0 0.8 0.8 -1.0 0.2 1.7 0.6
Crohns Disease (2012) 0.2 0.3 1.0 0.1 -0.2 -1.0 0.1 0.3 -0.8 0.6 -0.2
Mean Putamen Volume 0.7 0.8 3.3 -0.3 0.9 1.2 1.8 1.0 0.2 -0.2 -0.2
Fasting Glucose 0.4 0.5 1.9 0.6 0.4 0.0 -1.4 0.1 -0.2 -1.1 0.1
HbA1C 1.0 1.1 3.6 1.6 -1.4 -1.9 -0.2 0.3 -0.3 0.3 -0.4
HDL Cholesterol 1.1 1.8 6.4 -2.3 1.2 2.5 -0.8 0.5 0.3 0.6 -0.1
LDL Cholesterol 0.2 0.3 0.7 0.8 0.0 0.1 0.4 -0.5 0.5 -0.9 0.7
Lupus 0.8 1.2 3.7 1.9 -1.2 -0.9 0.8 0.0 1.6 -0.2 -0.2
Neuroticism (2016) 0.9 1.4 4.0 -0.2 -0.8 -1.0 -1.5 2.0 -0.5 -1.0 -1.3
Primary Biliary Cirrhosis 0.3 0.4 1.6 0.3 -0.2 -0.1 -0.3 -1.3 0.7 -0.7 0.6
Rheumatoid Arthritis 2.3 3.2 7.4 -1.2 1.1 1.9 1.0 -1.5 2.6 -1.5 2.7
Schizophrenia (2014) 0.2 0.5 2.1 -0.1 0.0 0.1 1.4 0.9 -0.8 -0.1 -0.2
Triglycerides 0.3 0.5 1.8 1.3 -0.3 -0.8 -0.3 -1.0 0.2 -0.5 0.7
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.1 0.0 0.4 1.0 0.7 -0.3 0.6 0.4 0.3
Ulcerative Colitis 0.7 1.0 3.8 1.2 0.6 -1.4 -0.7 -0.0 0.5 -2.0 0.2
Blood Eosinophil Count 1.0 8.1 26.4 0.1 2.2 1.7 0.8 -3.7 3.7 -1.6 5.1
Blood Platelet Count 0.0 0.4 2.1 0.3 -1.4 -0.5 -0.3 -0.2 0.1 -0.8 0.3
Blood Red Count 2.3 22.0 51.3 -1.8 -2.7 -3.1 -4.2 6.7 -6.2 2.0 -7.2
Blood White Count 0.0 0.3 1.0 -0.7 -0.6 0.3 -0.5 0.1 1.0 -0.7 -0.1
Heel T-Score 0.1 1.2 7.8 -0.5 -0.9 -0.1 -2.8 0.3 0.0 0.6 -0.2
BMI 0.5 2.6 4.7 -2.2 2.2 2.1 -1.1 -1.0 0.3 1.4 1.7
Height 0.1 2.6 6.2 0.0 -1.4 -0.7 -1.1 2.2 -2.2 1.0 -2.5
Waist Hip Ratio (WHR) 0.9 4.0 13.0 -0.4 -1.5 -1.7 -0.4 3.6 -1.6 0.7 -3.2
Systolic Blood Pressure 0.4 2.2 6.3 -2.5 1.5 2.2 -0.1 -0.2 0.4 2.0 0.8
Smoking Status 0.6 1.5 3.9 -1.3 1.1 0.8 -0.1 2.0 -0.9 1.7 -0.8
Allergy or Eczema 2.4 6.3 11.7 -3.4 2.8 3.2 1.8 -0.6 2.3 2.7 2.1
Cardiovascular Disease 1.4 4.6 8.8 -0.4 -2.5 -1.4 -2.0 2.9 -3.0 0.4 -2.7
Hypothyroidism (self reported) 0.3 0.6 2.5 1.6 -0.7 -0.8 -0.9 0.5 -0.3 -0.6 0.1
Respiratory disease 1.8 4.0 4.9 -2.2 2.2 2.0 1.4 -2.1 1.5 2.1 2.2
Type 2 Diabetes (T2D) (2018) 0.8 1.5 5.1 -0.6 0.0 0.1 -2.3 1.9 -1.1 -0.2 -1.2
Lung FEV1/FVC ratio 0.3 1.4 5.1 1.1 -1.1 0.0 -1.8 -0.3 0.4 -2.3 0.2
Lung FVC 3.0 15.4 31.8 0.7 -4.0 -4.0 -4.3 4.6 -4.4 -0.5 -5.6
Neuroticism 0.4 1.0 5.8 -0.0 0.4 0.3 -2.4 0.3 0.4 -1.0 0.7
Chronotype (morning person) 0.8 1.9 5.4 2.3 -0.8 -1.6 -1.4 1.1 -0.5 -0.9 -1.4
Hair Pigment 0.1 2.2 5.6 0.5 1.1 0.3 2.0 -2.4 1.9 0.0 1.8
Tanning 0.1 0.7 2.3 -1.5 -0.1 0.1 1.3 0.2 0.0 1.3 -0.2
Hand grip strength (left) 0.6 1.6 3.1 1.4 0.5 1.3 -0.7 -1.8 -0.1 -1.7 1.5
Number of treatments/medications taken 0.4 0.8 2.4 -0.8 0.4 0.7 -1.3 1.6 -0.8 -0.2 -0.4
Average weekly spirits intake 0.3 0.3 1.6 0.0 -0.7 -0.2 0.1 0.4 0.5 -1.3 0.4
Sensitivity / hurt feelings 0.4 0.7 3.6 0.2 -0.4 -0.4 -1.9 0.9 -0.5 0.5 -0.7
Frequency of depressed mood in last 2 weeks 2.5 3.4 7.4 -0.5 -1.2 -1.0 -2.4 2.7 -2.6 1.1 -1.9
Hearing difficulty/problems: Yes 0.3 0.5 2.1 0.1 0.1 1.1 -1.5 -0.6 0.4 -0.3 0.1
Relative age of first facial hair 0.6 1.2 3.9 -0.6 -1.1 -1.0 -0.5 2.0 -1.0 -0.4 -1.5
Other serious medical condition/disability diagnosed by doctor 1.4 1.8 5.6 -0.1 -0.2 -0.0 0.1 1.8 -2.0 1.1 -2.4
Ever used hormone-replacement therapy (HRT) 1.8 2.3 8.4 0.9 -1.4 -1.9 -0.1 1.7 -1.0 -0.2 -2.9
Ever had hysterectomy (womb removed) 2.0 2.3 4.3 0.6 -1.2 -1.4 -1.9 1.7 -1.8 0.4 -2.1
Systolic blood pressure, automated reading 0.5 1.3 3.4 -1.7 1.9 0.9 -0.6 0.7 0.5 1.5 0.0
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.5 1.0 -1.2 -0.2 0.2 1.1 -0.7 -0.0 -0.8
Angina 0.6 0.8 3.5 -0.4 0.6 1.9 0.1 -0.8 0.5 -0.6 1.1
Medication for hormone replacement therapy 2.0 2.2 4.3 1.5 -0.9 -2.1 0.8 1.4 -1.8 0.7 -2.1
Vitamin and mineral supplements 2.3 3.2 5.8 -1.0 2.1 2.3 0.9 -1.6 2.4 0.2 2.3
Supplements: Zinc 1.5 1.6 4.4 -2.0 0.7 1.5 2.1 -0.2 0.7 1.0 0.7
Medication: Co-codamol 1.5 1.7 3.8 0.4 -1.9 -1.7 0.2 1.4 -1.0 0.8 -1.9
Medication: Metformin 1.8 2.6 8.4 -0.1 -1.4 -0.4 -0.4 2.9 -2.7 0.3 -1.7
Diabetes (father) 0.7 0.8 3.7 0.7 -0.7 -0.8 1.9 0.3 -0.3 1.0 -0.2
Diabetes (mother) 0.1 0.2 0.5 0.1 -0.7 -0.3 -0.7 -0.0 -0.5 -0.2 0.2
Severe depression (siblings) 0.6 0.6 1.2 0.5 -1.1 -1.1 -0.8 0.8 -0.1 -1.0 -0.4
Pack years adult smoking proportion 0.5 0.8 1.9 -0.7 0.7 1.2 -0.6 -1.2 0.3 -0.3 1.4
Impedance of leg (right) 0.1 0.3 1.0 1.0 -0.6 -1.0 -0.1 0.2 -0.2 -0.2 -0.4
Leg fat-free mass (left) 0.2 0.9 1.8 -1.2 0.2 1.0 -1.3 0.1 -1.0 1.3 -0.2
Trunk fat percentage 0.2 1.0 2.0 -1.4 0.9 0.7 -1.3 0.2 0.7 1.3 0.7
Hand grip strength (right) 0.5 1.4 3.7 0.7 -0.2 1.5 0.3 -1.8 0.9 -0.7 1.9
Townsend deprivation index at recruitment 0.5 0.7 2.0 -0.7 -0.1 0.8 -1.4 -0.1 -1.4 -0.5 -0.0
Current tobacco smoking 0.5 0.8 2.3 -0.5 -0.1 0.2 0.7 1.1 -1.5 1.2 -0.6
Average weekly fortified wine intake 0.6 0.7 1.7 -0.9 0.9 1.3 -0.4 0.7 -0.5 -1.2 -0.5
Maternal smoking around birth 0.6 0.8 2.1 -0.4 -1.4 -0.5 -0.6 1.4 -0.1 0.7 -1.2
Fed-up feelings 1.0 1.8 4.4 -2.1 0.4 1.4 -1.4 1.7 -1.7 0.7 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 3.1 -0.2 -0.8 -0.5 0.1 1.5 -1.3 0.5 -1.8
Relative age voice broke 1.3 1.9 3.8 1.1 -1.5 -1.4 1.6 1.1 -2.0 -0.3 -1.5
Taking other prescription medications 1.0 1.5 5.2 -2.3 0.6 2.1 -0.4 1.1 -0.1 0.5 -0.1
Age when periods started (menarche) 0.5 1.3 3.5 0.5 0.6 -0.0 1.0 -1.9 1.9 0.3 1.2
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 4.6 -1.1 -0.3 -0.5 -1.7 1.6 -1.0 -0.8 -2.1
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.0 -0.4 0.6 0.7 -0.8 0.1 1.0 -0.1 0.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.5 -1.1 0.0 0.4 -1.6 -0.4 -0.2 1.2 0.1
Qualifications: CSEs or equivalent 0.5 0.7 3.0 -0.2 -1.7 -0.1 -0.3 0.8 -0.4 0.2 -1.1
Serious illness, injury or assault to yourself 3.9 4.7 8.2 -2.6 -1.6 0.3 -2.2 2.9 -2.1 1.6 -2.9
High blood pressure 0.8 2.1 4.6 -0.7 -0.9 -0.4 -2.1 1.8 -2.0 1.1 -1.7
Hayfever, allergic rhinitis or eczema 1.9 4.1 7.5 -2.7 2.3 2.7 1.4 -0.8 1.3 2.5 1.6
Multivitamins +/- minerals 1.8 2.2 5.6 0.6 -1.3 -1.7 -0.4 1.6 -2.4 -0.5 -2.1
Stomach or abdominal pain in last month 0.4 0.5 1.9 0.9 -0.6 -0.3 -1.4 -0.1 -0.8 -0.6 0.1
Supplements: Glucosamine 1.9 2.5 7.2 -0.6 -0.9 -1.1 -1.9 2.4 -1.1 -0.3 -2.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.8 0.7 -0.0 -0.5 -1.4 0.1 -0.7 0.6 0.2
Medication: Atenolol 0.3 0.4 2.1 0.4 -0.3 -0.1 0.0 0.6 -0.4 -1.5 -0.4
Medication: Levothyroxine sodium 0.1 0.2 0.4 -0.6 -0.1 0.7 -0.2 0.4 0.5 0.4 -0.1
Sitting height 0.8 5.8 14.3 1.0 -2.2 -1.8 -1.1 2.7 -3.8 1.4 -3.5
Chronic bronchitis/emphysema (father) 3.6 4.3 6.8 0.8 -2.3 -2.6 -2.2 2.6 -1.9 -0.2 -2.5
High blood pressure (mother) 1.1 1.6 6.3 -2.5 0.0 0.8 0.2 0.6 -0.2 2.2 0.1
Body mass index (BMI) 0.5 2.0 3.7 -1.9 1.6 1.9 -1.5 -0.6 0.5 1.0 1.4
Impedance of leg (left) 0.1 0.3 0.9 0.9 -0.3 -0.7 0.6 -0.2 0.5 0.3 0.1
Leg predicted mass (left) 0.2 0.9 1.9 -1.3 0.2 1.0 -1.3 0.1 -1.1 1.4 -0.3
Trunk fat mass 0.2 1.1 2.5 -1.5 0.9 0.8 -1.3 0.4 0.3 1.6 0.5
Waist circumference 0.2 0.9 2.9 -1.7 0.9 0.9 -0.7 0.3 0.1 1.4 0.2
Number of incorrect matches in round 1.4 2.3 6.5 0.6 2.0 1.1 0.7 -2.1 1.2 -0.2 2.6
Past tobacco smoking 0.4 0.7 3.3 0.6 -1.8 -0.9 0.5 -0.2 -0.3 -0.6 -0.4
Alcohol usually taken with meals 1.4 2.3 6.1 0.4 -1.8 -2.5 -0.8 1.9 -0.8 -0.5 -1.9
Nervous feelings 0.3 0.5 1.3 0.7 0.6 0.5 0.2 -0.8 0.8 -0.4 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.3 0.0 0.1 -0.0 -0.5 0.3 -0.3 -0.5 0.3
Hearing difficulty/problems with background noise 0.2 0.3 1.0 0.5 -0.5 -0.4 -1.0 0.0 -0.5 0.1 -0.0
Hair/balding pattern: Pattern 2 1.2 1.6 4.1 0.4 -1.7 -1.0 0.1 1.0 -1.7 0.5 -2.0
Had menopause 0.4 0.6 1.5 -0.0 0.0 -0.6 -0.6 1.0 0.7 -0.9 -1.2
Had other major operations 0.8 1.0 2.8 -0.2 0.2 0.6 -1.5 1.7 -0.2 -1.4 -0.8
Forced vital capacity (FVC) 2.7 10.4 25.2 1.0 -3.6 -2.9 -2.0 4.1 -3.8 -1.2 -5.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.8 4.3 -0.8 0.3 0.6 -2.1 0.6 0.8 0.1 0.2
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.3 -0.5 -0.0 -0.7 -0.6 0.3 -1.1 0.9 -0.2
Qualifications: None of the above 0.4 0.9 3.3 0.9 -0.5 -1.8 -0.6 0.6 -1.1 -0.9 -0.5
Financial difficulties in last 2 years 1.1 1.5 3.2 -0.9 -1.2 0.8 -0.6 1.5 -1.8 1.1 -1.6
Mouth/teeth dental problems 0.3 0.5 2.5 -0.6 -1.6 -0.1 -0.4 0.5 0.3 0.5 -0.8
Heart attack 0.7 0.9 1.9 -0.6 0.7 1.3 0.8 0.4 1.0 -1.4 1.0
Allergy 2.5 5.6 10.3 2.8 -2.8 -3.2 -1.9 1.4 -2.1 -1.8 -2.4
Pain all over the body in last month 2.9 3.1 9.9 0.8 -1.3 -1.8 -0.9 1.5 -2.5 0.6 -3.1
Diabetes (self-reported) 1.3 2.0 5.9 -0.1 -0.1 -1.0 -2.4 2.4 -0.8 -0.5 -1.4
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 4.2 -1.6 0.6 1.1 1.4 -1.2 0.5 2.0 0.8
Medication: Ramipril 0.9 1.2 5.8 0.1 -0.5 -0.5 -2.4 1.3 -0.2 -1.2 -0.0
Medication: Simvastatin 0.7 1.0 3.6 0.5 0.2 -0.2 -1.9 0.8 -0.5 -1.8 -0.3
Fluid intelligence score 0.9 1.9 12.2 -1.1 0.4 0.3 -1.2 -0.2 -0.3 3.5 -0.3
Illnesses of siblings 0.3 0.4 0.9 0.8 -0.9 0.2 0.8 0.4 -0.4 -0.5 -0.4
Neuroticism score 0.4 0.7 2.4 -0.1 0.9 0.9 -1.0 -0.8 0.3 0.1 1.5
Weight 0.3 1.3 2.8 -1.7 1.0 1.4 -1.6 0.1 -0.3 1.3 0.4
Impedance of arm (right) 0.2 0.9 2.4 1.1 -0.7 -1.6 -0.1 0.8 -0.1 -1.2 -0.8
Arm fat percentage (right) 0.3 1.1 2.7 -1.4 1.3 0.8 -1.6 -0.1 0.5 0.9 1.0
Trunk fat-free mass 0.1 0.8 1.9 -0.6 -0.3 0.7 -1.2 -0.0 -1.4 1.3 -0.5
Hip circumference 0.3 1.3 2.4 -1.1 1.5 1.5 -0.5 -1.0 1.0 0.3 1.6
Time employed in main current job 0.8 0.9 2.5 1.5 0.8 -1.1 -0.7 -0.1 0.0 -1.6 0.2
Alcohol intake versus 10 years previously 0.4 0.6 1.7 -0.8 0.3 1.2 1.3 -0.2 0.5 0.0 0.8
Father’s age at death 1.2 1.5 5.5 0.2 0.8 -0.6 -2.3 -1.2 -0.5 2.0 0.0
Worrier / anxious feelings 0.6 1.2 3.4 0.4 1.8 0.6 -0.6 -1.1 1.2 -0.9 1.2
Frequency of tiredness / lethargy in last 2 weeks 3.5 5.7 11.6 0.2 -2.3 -2.1 -2.6 2.7 -3.4 0.5 -3.2
Falls in the last year 0.9 1.2 2.2 -1.4 0.0 1.2 -0.5 1.2 -1.5 1.4 -0.2
Hair/balding pattern: Pattern 3 0.2 0.4 1.0 -0.2 0.7 -0.1 -0.8 -0.4 0.7 0.0 1.0
Number of live births 0.6 0.9 2.5 -0.2 -0.8 -0.5 0.7 1.0 -0.2 1.6 -1.5
Forced expiratory volume in 1-second (FEV1) 3.6 12.1 24.9 1.7 -4.3 -3.1 -2.9 3.9 -4.0 -1.6 -5.0
Pulse rate 0.1 0.1 0.4 -0.5 0.0 0.1 0.7 0.5 0.3 -0.0 -0.3
Happiness 0.8 0.9 3.4 -0.2 1.0 1.8 0.3 -1.0 0.7 0.2 1.2
Noisy workplace 0.5 0.6 2.4 -0.6 -0.3 0.3 1.5 0.8 -0.7 0.9 -0.5
Qualifications: A levels/AS levels or equivalent 0.7 1.5 3.7 -1.6 -0.2 -0.1 -1.9 1.2 -0.5 0.7 -1.7
Serious illness, injury or assault of a close relative in last 2 years 1.8 2.0 9.6 -0.4 -0.3 -0.6 -1.5 0.5 -3.1 1.4 -1.3
Mouth/teeth dental problems: Dentures 0.6 1.0 3.1 0.6 1.5 0.1 0.7 0.3 0.5 -1.8 1.0
Asthma 1.9 3.7 6.9 -1.9 2.6 2.2 1.5 -1.5 1.6 1.5 2.3
Medication: Ibuprofen (e.g. Nurofen) 3.6 4.6 7.9 0.5 -2.6 -2.0 -1.6 2.8 -2.8 -0.4 -2.7
Medication: Cholesterol lowering 0.5 0.7 1.7 -1.0 0.9 0.8 -1.3 1.2 0.2 -0.5 0.4
Depression (self-reported) 0.8 1.0 2.6 -0.7 -1.6 -0.6 -0.9 1.1 -0.7 -0.3 -1.3
Medication: Lansoprazole 0.4 0.5 1.1 0.8 0.6 0.3 -0.5 -0.7 0.5 -1.0 0.8
Prospective memory result 0.2 0.3 1.3 -0.4 -0.0 0.2 0.9 -0.2 1.1 -0.1 0.4
Lung cancer (father) 0.5 0.6 2.2 -0.5 1.5 0.7 0.5 0.2 1.1 -0.1 0.3
Illnesses of mother 0.7 0.9 4.8 1.1 -0.0 -0.0 2.2 -0.7 -0.6 0.5 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.7 8.7 18.3 0.9 -3.7 -2.2 -2.8 3.5 -3.3 -1.4 -4.3
Pulse wave Arterial Stiffness index 1.3 1.5 3.0 0.1 1.2 -0.5 1.7 -1.7 0.4 1.6 1.2
Impedance of arm (left) 0.2 0.8 3.1 1.2 -0.8 -1.8 -0.0 0.4 -0.3 -0.6 -0.7
Arm fat mass (right) 0.2 1.0 2.7 -1.4 1.0 1.0 -1.6 0.2 0.2 0.9 0.5
Trunk predicted mass 0.1 0.8 2.2 -0.6 -0.4 0.6 -1.3 0.0 -1.5 1.3 -0.5
Standing height 0.2 1.6 4.1 0.6 -1.5 -0.9 -0.6 1.2 -1.7 0.9 -2.0
Length of working week for main job 0.9 1.0 3.5 -0.5 -0.7 0.5 0.1 0.4 -1.5 1.9 -1.1
Exposure to tobacco smoke at home 0.2 0.2 1.2 -0.3 0.2 0.3 -1.1 0.5 -0.0 -0.2 -0.0
Breastfed as a baby 2.0 2.5 9.5 0.2 1.2 0.4 0.5 -1.9 3.1 -1.2 1.8
Tense / ‘highly strung’ 0.2 0.3 1.0 0.7 0.3 0.2 -0.1 -0.1 0.5 -1.0 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 2.3 3.5 4.9 1.3 -1.8 -1.8 -2.2 2.2 -2.0 -1.7 -1.7
Hair/balding pattern: Pattern 4 2.1 5.2 12.4 1.1 2.0 0.9 -0.6 -3.1 3.2 -1.6 3.5
Birth weight of first child 1.0 1.9 6.4 0.3 0.2 -1.2 -2.5 1.9 -1.0 -0.6 -1.4
Peak expiratory flow (PEF) 0.7 1.5 3.6 1.3 -1.1 -0.3 -1.5 1.0 -0.6 -1.9 -1.4
Pulse wave reflection index 0.5 0.7 1.9 0.8 -0.9 -1.4 -0.2 -0.5 -1.0 0.6 -0.4
Ever highly irritable/argumentative for 2 days 0.7 0.9 2.0 1.3 0.5 -0.6 -0.4 -1.3 0.5 -0.7 1.4
Loud music exposure frequency 2.0 2.2 8.5 0.0 0.7 0.7 2.9 -1.3 1.3 1.6 1.4
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 4.6 -2.1 1.3 1.0 -1.4 -0.3 0.9 2.2 -0.5
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 4.8 1.5 0.3 -1.0 -0.3 -2.2 -0.2 0.7 1.4
Blood clot in the leg (DVT) 2.3 3.0 8.2 0.6 1.1 1.1 1.4 -1.9 2.9 -1.4 2.4
Medication: Paracetamol 1.9 3.2 11.4 -1.7 -0.0 0.1 -1.4 1.5 -3.4 2.1 -1.7
Headache pain in last month 0.7 1.3 4.2 -0.1 -1.1 -0.7 -0.3 1.1 -2.1 0.7 -1.6
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 2.2 0.7 -0.9 -0.9 1.5 -0.4 -0.4 0.6 -0.8
Glaucoma (self-reported) 0.6 0.7 2.2 -1.4 0.4 0.5 0.5 0.4 -0.7 1.5 -0.4
Gout (self-reported) 0.1 0.2 0.5 -0.0 0.0 0.2 -0.7 0.2 0.4 -0.5 0.5
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 0.8 -0.5 -0.8 -0.8 0.7 0.2 -0.2 -0.2
Medication: Amlodipine 0.1 0.1 0.3 -0.4 -0.0 0.5 0.3 0.0 0.4 0.0 -0.1
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.7 -0.8 -0.3 -0.5 0.1 -0.3 -0.1 0.9 0.6
Birth weight 0.8 1.7 4.0 0.6 -1.1 -1.4 -0.1 1.5 -1.3 2.0 -1.5
Chronic bronchitis/emphysema (mother) 2.3 2.6 8.8 -1.4 -1.1 0.7 -0.2 3.0 -1.9 -0.5 -2.1
High blood pressure (siblings) 0.5 0.7 3.1 0.9 0.2 -0.8 -1.8 0.3 -0.7 0.4 -0.4
Forced vital capacity (FVC), Best measure 2.5 9.2 21.1 0.5 -3.5 -2.5 -2.5 3.7 -3.5 -1.1 -4.6
Body fat percentage 0.3 1.3 2.4 -1.5 1.3 0.8 -1.5 0.0 0.8 1.3 1.0
Leg fat percentage (right) 0.7 2.4 4.2 -1.7 2.1 1.5 -1.8 -0.8 1.2 1.3 1.7
Arm fat-free mass (right) 0.1 0.6 2.2 -0.9 -0.1 0.9 -0.8 0.0 -0.7 1.5 -0.2
Exposure to tobacco smoke outside home 0.4 0.6 1.2 -0.8 1.1 1.1 1.1 0.3 0.1 -0.0 0.4
Comparative body size at age 10 0.6 1.7 4.2 -2.0 -0.0 0.8 -0.2 1.6 -0.6 2.0 -1.4
Number of full brothers 0.6 0.8 2.8 -0.3 -1.1 -0.1 0.4 0.3 -1.7 1.1 -0.7
Worry too long after embarrassment 1.8 3.0 6.9 0.4 1.3 0.9 -1.7 -2.6 2.2 0.4 2.6
Seen a psychiatrist for nerves, anxiety, tension or depression 2.4 3.1 9.0 1.4 -2.2 -2.0 1.2 1.2 -3.0 -0.2 -1.4
Wheeze or whistling in the chest in last year 0.5 1.0 3.0 -1.2 1.0 -0.3 -0.4 0.1 -1.4 1.7 0.3
Number of children fathered 2.0 2.3 6.5 -0.1 -0.8 -1.6 -0.7 2.4 -1.4 -0.0 -2.5
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 3.3 -0.5 -0.5 -0.7 -1.3 1.8 -1.1 1.1 -1.5
Age at first live birth 0.4 0.7 3.6 -0.1 0.9 0.8 0.0 -0.8 0.3 1.9 0.5
Pulse wave peak to peak time 1.0 1.2 2.5 -0.1 -1.0 0.7 -1.6 1.5 -0.1 -1.6 -1.0
Health satisfaction 0.3 0.4 1.5 -0.5 -0.4 -0.5 -0.8 0.2 -0.6 1.2 -0.4
Shortness of breath walking on level ground 0.3 0.4 1.4 0.1 -0.3 -0.3 0.4 1.2 -0.9 -0.0 -0.4
Qualifications: College or University degree 0.2 0.7 1.6 -0.5 -0.3 -0.8 -0.7 1.0 -1.1 0.2 -1.3
Eye problems/disorders: None of the above 0.9 1.0 2.8 0.8 0.6 0.1 1.0 -1.4 1.7 0.4 1.1
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.6 -0.9 1.9 0.6 0.9 -0.7 -0.4 1.9 -0.1
Emphysema/chronic bronchitis 0.6 0.7 2.3 -1.0 1.5 1.3 -0.1 -0.6 0.2 0.2 0.4
Medication for pain relief, constipation, heartburn 2.9 4.9 10.7 0.9 1.3 1.1 2.9 -2.9 3.3 0.4 2.7
Neck or shoulder pain in last month 0.6 0.8 2.9 -0.1 -0.3 -0.2 -0.6 1.1 -1.7 0.5 -1.2
Medication: Blood pressure 0.2 0.4 2.2 -0.1 0.7 0.5 -1.5 0.1 0.3 0.4 0.5
Angina (self-reported) 0.7 0.9 3.9 -0.4 0.8 2.0 0.2 -0.7 0.4 -0.8 1.0
Migraine (self-reported) 2.1 2.6 4.4 1.3 -1.8 -2.0 1.1 1.7 -1.6 1.0 -2.1
Medication: Ibuprofen 1.3 1.6 3.3 0.4 -1.7 -1.1 -0.8 1.8 -1.3 -1.0 -1.3
Medication: Allopurinol 0.1 0.1 0.3 -0.5 -0.2 0.2 -0.2 0.5 -0.3 -0.0 0.0
Medication: Omeprazole 1.3 1.5 3.9 -0.6 -0.8 0.3 -1.6 2.0 -0.7 -1.5 -1.4
Medication: Seretide 50 evohaler 4.7 5.4 12.2 -1.7 3.0 3.5 3.3 -1.2 2.1 0.0 1.5
Mean time to correctly identify matches 0.7 1.2 3.6 0.9 0.9 -0.7 1.2 -1.3 1.9 0.2 1.0
Heart disease (mother) 1.1 1.3 3.0 -1.2 1.4 1.4 0.4 -0.4 1.7 -0.1 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.4 0.2 0.5 0.4 0.3 0.2 -0.3 -0.1 -0.7
Whole body fat mass 0.3 1.2 2.8 -1.6 1.0 0.9 -1.7 0.2 0.2 1.5 0.6
Leg fat mass (right) 0.4 1.7 3.5 -1.6 1.4 1.2 -1.9 -0.2 0.3 1.6 1.0
Arm predicted mass (right) 0.2 0.8 2.6 -1.1 -0.0 1.2 -0.9 0.0 -0.6 1.6 -0.1
Pulse rate, automated reading 0.2 0.6 1.6 1.1 -0.9 -1.3 -0.2 0.8 0.1 -0.1 -0.7
Alcohol intake frequency. 0.4 0.8 4.9 0.3 0.1 0.9 -0.0 -0.5 0.7 -2.2 0.3
Comparative height size at age 10 0.4 2.2 5.2 -0.1 -1.4 -1.0 0.3 2.3 -2.1 1.0 -2.0
Number of full sisters 2.3 2.7 8.4 2.3 -2.3 -2.9 -1.4 -0.1 0.4 0.1 -0.9
Suffer from ‘nerves’ 0.2 0.4 1.1 0.9 -0.6 -0.0 -0.3 0.8 -0.1 -1.0 -0.2
Overall health rating 0.4 0.8 1.8 -0.5 0.3 0.6 -0.4 1.2 -1.1 1.3 -0.9
Chest pain or discomfort 2.8 4.0 13.2 -2.9 -0.0 0.5 -1.5 1.0 -2.2 3.6 -1.3
Had major operations 2.6 3.1 8.6 -2.9 1.3 2.9 0.1 -0.6 -0.1 1.6 1.8
Age at last live birth 0.7 1.0 6.9 0.0 -0.1 -0.5 0.4 0.2 -0.5 2.6 -0.7
Family relationship satisfaction 1.6 1.9 6.3 -0.5 2.5 1.3 0.9 -1.4 1.1 0.1 1.8
Leg pain on walking 1.2 1.5 4.3 -0.2 -0.7 -0.8 -0.5 1.9 -2.1 -0.4 -1.5
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 2.1 -0.1 -0.4 1.2 -0.5 -1.5 0.5 0.5 1.1
Commuting to job workplace: Car/motor vehicle 1.8 2.0 5.5 2.3 -1.6 -1.4 0.2 -0.1 0.8 -2.3 0.2
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 4.1 1.0 0.1 -0.2 1.6 -1.7 2.0 -0.9 1.3
Medication: Aspirin 0.5 0.7 2.1 -0.1 0.4 0.4 -0.8 1.2 -0.5 -1.4 -0.6
Supplements: Vitamin C 0.7 0.8 1.9 0.9 -1.1 -1.4 -0.3 0.5 -0.1 -1.1 -0.9
Knee pain experienced in last month 0.7 1.1 3.0 -0.9 1.1 1.1 -0.9 -0.3 1.7 -1.0 0.8
Hypertension (Self-reported) 0.5 1.4 4.3 -0.5 -0.6 -0.0 -2.1 1.6 -1.5 0.5 -1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.6 -0.3 0.3 1.1 1.2 -1.0 0.5 -0.5 0.9
Illnesses of father: Heart disease 2.4 3.3 9.3 -1.5 0.6 -0.2 -3.1 2.2 -2.0 1.2 -2.0
Illnesses of siblings: Diabetes 0.2 0.2 0.7 -0.7 0.1 -0.3 0.4 0.3 0.8 -0.1 -0.3
Smoking status: Previous 0.4 0.6 2.0 -0.4 1.4 0.7 -1.2 0.5 0.8 -0.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 3.6 -0.4 -1.4 -0.3 0.9 1.3 -1.9 1.8 -1.5
Whole body fat-free mass 0.2 0.9 2.4 -1.0 -0.1 0.9 -1.2 0.1 -1.1 1.5 -0.4
Leg fat-free mass (right) 0.1 0.8 2.5 -1.2 0.2 1.2 -0.7 -0.2 -0.8 1.6 -0.0
Arm fat percentage (left) 0.3 1.1 2.0 -1.4 1.3 0.8 -1.3 -0.3 0.5 1.0 1.1
Average weekly red wine intake 0.5 0.7 1.7 -1.3 0.4 -0.5 -1.0 1.1 -0.1 0.2 -1.1
Handedness (chirality/laterality): Left-handed 1.2 1.4 5.4 -2.3 0.7 1.9 -0.4 0.3 -0.6 0.4 -0.7
Mood swings 0.5 0.8 3.3 -1.8 0.3 1.1 0.0 0.4 -1.0 0.7 0.5
Loneliness, isolation 2.8 3.8 9.4 0.2 -0.9 -1.4 -2.6 2.5 -3.1 0.8 -2.1
Long-standing illness, disability or infirmity 2.7 4.2 10.5 -1.3 -0.9 -0.0 -2.0 3.1 -2.4 1.1 -3.2
Ever had bowel cancer screening 1.1 1.3 3.8 0.1 -0.9 -0.7 -0.9 1.2 -1.6 0.3 -1.9
Diabetes diagnosed by doctor 0.9 1.4 5.3 -0.1 -0.3 -0.5 -1.5 2.3 -1.1 -0.7 -1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 3.2 -1.0 0.2 0.4 0.0 1.8 0.7 0.4 -1.1
Friendships satisfaction 1.2 1.5 4.7 -0.5 2.2 1.2 -0.2 -1.3 -0.7 1.4 1.1
Qualifications: nursing, teaching 0.6 0.9 2.5 -0.8 1.3 1.6 0.4 -0.3 0.5 1.4 -0.1
Commuting to job workplace: Walk 0.4 0.4 1.3 -1.1 0.2 0.4 -0.8 0.5 -0.6 0.1 -0.7
Eye problems/disorders: Cataract 1.1 1.3 3.6 0.1 -1.2 -1.0 -1.9 1.0 -1.4 -1.1 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.5 2.3 7.3 1.6 -1.0 -0.9 -1.5 1.4 -0.8 -2.7 -1.5
Medication for cholesterol 1.9 2.9 5.7 -0.9 1.8 2.3 1.2 -1.8 2.0 0.2 2.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.1 3.7 7.0 0.7 -2.1 -2.4 -2.3 1.7 -2.6 0.6 -1.8
Back pain experienced in last month 5.2 7.7 19.4 0.4 -2.1 -1.9 -2.0 4.1 -3.5 -0.3 -4.4
Mineral and other dietary supplements 1.3 1.8 4.7 1.1 0.3 1.0 1.8 -2.2 0.1 0.2 1.9
Breast cancer (self-reported) 0.4 0.5 1.5 -0.8 1.2 0.6 -1.1 -0.2 0.1 0.5 -0.4
Asthma (self-reported) 2.0 4.0 8.2 -1.7 2.9 2.2 1.4 -1.7 1.8 1.3 2.5
Osteoporosis (self-reported) 1.7 2.1 6.3 0.9 -1.5 -1.6 -0.6 1.0 -1.1 1.6 -2.5
Osteoarthritis (self-reported) 1.3 1.6 6.5 -1.2 -0.5 -0.4 0.3 2.5 -1.2 0.5 -1.8
Medication: Aspirin 0.7 0.9 2.4 -0.1 0.2 0.2 -1.3 1.5 -0.7 -1.6 -0.9
Medication: Gliclazide 0.7 0.8 2.3 -0.1 1.5 1.5 -0.5 -0.1 0.5 -0.8 1.0
Illnesses of father: None of the above (group 1) 1.1 1.3 3.0 0.8 0.0 0.5 1.4 -1.1 1.3 -1.7 1.3
Smoking status: Current 0.4 0.7 1.9 -0.8 0.2 0.4 0.8 0.8 -1.4 1.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.3 9.0 22.2 -0.2 -2.5 -1.7 -4.7 3.9 -2.8 -1.3 -4.0
Whole body water mass 0.1 0.8 2.1 -0.8 -0.2 0.8 -1.2 0.1 -1.2 1.4 -0.4
Leg predicted mass (right) 0.2 0.9 3.0 -1.2 0.2 1.2 -0.8 -0.2 -0.8 1.7 -0.0
Arm fat mass (left) 0.2 1.0 2.2 -1.5 0.9 1.0 -1.4 -0.0 0.0 1.3 0.6
Number of self-reported non-cancer illnesses 0.9 1.6 5.4 -2.3 0.3 1.0 -0.4 2.2 -0.4 0.3 -1.0
Average weekly champagne plus white wine intake 1.6 2.2 4.2 1.1 -1.8 -1.3 -0.8 1.7 -1.3 -2.0 -1.4
Miserableness 0.3 0.5 1.9 -0.1 0.7 0.6 -1.1 0.1 -1.4 0.5 0.4
Guilty feelings 1.1 1.6 4.2 1.8 -0.8 -1.0 -2.1 -0.8 -0.1 -1.6 0.7
Wears glasses or contact lenses 0.5 0.6 2.4 0.1 -0.3 0.1 0.3 1.5 -0.4 -0.6 -1.1
Ever taken oral contraceptive pill 0.7 0.8 3.1 1.8 -1.4 -0.5 0.8 -0.1 -0.2 -0.7 -0.1
Hearing aid user 0.2 0.3 1.5 0.1 -0.5 0.2 -0.4 0.3 1.2 0.0 0.0
Mother’s age at death 2.1 2.6 6.3 2.5 1.0 -1.0 -0.7 -2.1 1.5 -1.7 1.7
Financial situation satisfaction 1.2 1.5 5.8 0.4 -0.3 1.3 0.2 -0.9 2.4 -1.4 1.3
Tinnitus: Yes, now most or all of the time 0.8 1.0 3.8 1.0 -0.2 0.2 2.0 0.1 -0.7 1.4 -0.5
Commuting to job workplace: Public transport 1.7 2.0 6.1 -2.1 2.5 1.4 0.2 -0.5 0.3 1.8 0.4
Eye problems/disorders: Glaucoma 0.7 0.8 3.0 -1.5 0.4 0.8 0.4 0.0 -0.8 1.7 0.0
Medication: Blood pressure 0.3 0.6 1.6 -0.3 -0.8 0.1 -1.0 1.3 -0.6 -0.1 -1.1
Pain type(s) experienced in last month: Hip pain 0.3 0.3 1.0 0.3 0.0 -0.0 0.4 0.8 -0.7 1.0 -0.5
Supplements: Fish oil (including cod liver oil) 1.4 1.8 5.6 -0.9 -0.5 -1.1 -1.1 2.4 -0.9 -0.4 -2.1
High cholesterol (Self-reported) 0.8 1.5 4.0 0.0 -0.6 -0.6 -2.0 2.0 -0.8 -1.2 -1.2
Medication: Bendroflumethiazide 0.2 0.3 1.1 -0.6 1.0 0.7 -0.2 -0.5 -0.1 0.2 0.6
Medication: Paracetamol 2.1 3.2 8.1 -2.2 0.5 0.7 -1.8 1.3 -2.8 2.5 -0.9
Medication: Lisinopril 0.2 0.3 0.6 -0.1 0.7 0.8 -0.4 0.6 0.2 0.1 -0.6
Medication: Atorvastatin 0.2 0.3 0.8 -0.0 -0.1 0.6 0.6 0.3 0.0 0.6 0.9
Illnesses of father: High blood pressure 0.4 0.5 1.9 -0.5 0.5 -0.0 -1.4 0.3 -0.7 0.9 -0.5
Alcohol drinker status: Never 1.1 1.3 3.9 -1.4 0.8 2.0 0.7 -1.2 0.8 0.7 0.9
Ever smoked 0.1 0.2 0.7 0.3 0.9 -0.0 -0.4 -0.1 -0.2 0.8 0.3
Basal metabolic rate 0.2 0.9 2.4 -1.0 0.1 1.0 -1.2 -0.1 -1.0 1.6 -0.1
Leg fat percentage (left) 0.8 2.8 5.3 -1.7 2.3 1.6 -1.5 -0.9 1.6 1.4 1.9
Arm fat-free mass (left) 0.2 0.9 2.3 -1.1 0.1 1.2 -1.3 0.1 -0.6 1.5 -0.2
Number of operations (self-reported) 2.2 3.2 10.5 -3.2 1.5 2.9 -1.2 1.3 -1.1 0.6 0.0
Average weekly beer plus cider intake 1.3 1.8 4.0 -1.1 1.4 1.1 1.2 -1.5 0.2 2.0 1.5
Irritability 0.8 1.3 4.9 -2.0 0.6 0.6 -0.7 0.1 -0.2 2.2 0.4
Risk taking 0.5 0.8 1.9 -1.0 -0.4 1.4 1.3 0.0 -0.6 -0.9 -0.2
Ever had prostate specific antigen (PSA) test 1.4 1.7 3.7 -1.5 0.0 -1.0 -1.9 1.4 -0.4 1.4 -1.5
Fractured/broken bones in last 5 years 1.8 2.4 6.6 -1.7 -0.9 0.2 -0.9 1.9 -2.6 0.8 -1.8
Age started oral contraceptive pill 0.7 0.9 2.8 -0.2 1.2 0.4 1.0 -0.2 1.7 -1.1 0.7
Diastolic blood pressure, automated reading 0.1 0.5 1.9 -0.5 0.2 -0.4 -1.4 1.0 -0.5 0.4 -0.1
Ever depressed for a whole week 1.6 2.0 6.3 0.7 -1.0 -2.5 -1.8 1.2 -1.2 0.1 -1.3
Unable to work because of sickness or disability 1.7 2.2 5.0 0.2 -1.9 -0.6 -0.2 1.4 -2.0 1.7 -2.2
Commuting to job workplace: Cycle 0.8 1.0 1.9 -1.1 0.2 1.2 0.7 -0.8 1.4 0.9 1.0
Myopia 1.2 1.7 3.7 -1.1 1.4 1.9 -1.5 -0.8 0.4 -1.5 1.1
Vascular/heart problems diagnosed by doctor 0.8 2.1 4.6 -0.0 1.4 1.0 2.1 -2.0 1.8 -0.3 1.6
Cholesterol lowering medication 0.7 1.0 1.9 0.0 -0.9 -0.6 -1.3 1.4 -0.7 -0.9 -1.3
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 4.8 -1.1 -0.4 0.2 -2.2 1.4 -0.4 -1.3 -1.1
Pain experienced in last month 2.1 3.6 8.3 -0.2 1.3 1.7 1.7 -2.4 2.6 0.6 2.9
Supplements: Calcium 0.7 0.8 2.6 -0.8 -0.1 -0.1 0.2 1.2 -1.1 0.5 -1.6
Basal cell carcinoma (self-reported) 0.6 0.7 1.5 0.4 0.4 0.2 -1.2 1.2 -1.1 0.5 -1.1
Heart attack/myocardial infarction (self-reported) 0.9 1.1 2.3 -0.7 0.8 1.5 1.2 0.3 1.1 -1.2 1.2
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 9.0 0.6 1.1 1.0 1.3 -1.9 3.0 -1.4 2.5
Heart disease (siblings) 1.3 1.6 4.6 -0.6 1.6 0.2 0.4 -2.1 0.9 0.6 1.9
Alcohol drinker status: Previous 0.6 0.6 2.3 -1.1 0.0 1.5 -0.9 0.6 0.1 -0.2 -0.7
Pack years of smoking 1.1 1.6 4.1 -0.9 1.3 1.6 -0.4 -1.6 0.8 -0.3 2.0
Impedance of whole body 0.1 0.6 1.9 1.2 -0.8 -1.4 0.4 0.3 0.3 -0.3 -0.4
Leg fat mass (left) 0.4 1.6 2.7 -1.6 1.5 1.2 -1.6 -0.2 0.5 1.5 1.1
Arm predicted mass (left) 0.2 1.0 3.2 -1.2 0.0 1.1 -1.3 0.3 -0.8 1.8 -0.4