TWAS hub - MITF

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Spleen	0.377	0.100	1.1e-04	0.290	NA	0.159	NA	0.271	3.8e-08	NA	7.0e-05	NA	1.2e-07
2	TCGA	Thyroid Carcinoma	0.115	0.039	9.9e-07	0.077	0.078	0.084	NA	0.094	5.7e-08	4.5e-08	1.5e-08	NA	1.8e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Wears glasses or contact lenses	6.7	7.8	15.2	-0.6	3.9
Tinnitus: Yes, now most or all of the time	6.1	7.2	10.1	-2.1	-3.2
Guilty feelings	5.9	8.9	9.4	2.9	3.1
Blood Red Count	5.8	55.8	67.7	8.2	-6.6
Pulse rate	4.9	8.3	10.0	3.2	-2.6
Heart attack/myocardial infarction (self-reported)	4.9	6.3	7.6	-2.8	-2.2
High cholesterol (Self-reported)	4.6	8.2	16.5	4.1	-0.0
Heart attack	4.5	5.8	7.2	-2.7	-2.1
Exposure to tobacco smoke outside home	4.3	5.7	6.2	2.3	2.5
Townsend deprivation index at recruitment	4.2	5.9	6.7	2.3	2.6
Chronic bronchitis/emphysema (father)	3.9	4.6	8.7	-0.7	2.9
Sensitivity / hurt feelings	3.5	5.9	9.4	3.1	1.6
Heart disease (mother)	3.5	4.3	6.5	-2.5	-1.4
Type 2 Diabetes (T2D) (2012)	3.4	3.9	5.1	2.3	-1.7
Blood Platelet Count	3.4	39.9	69.6	-8.3	-3.2
Worry too long after embarrassment	3.2	5.4	7.8	1.8	2.8
Schizophrenia (2018)	3.0	6.2	9.1	1.8	-3.0
Taking other prescription medications	3.0	4.6	8.3	2.9	1.0
Impedance of leg (left)	3.0	14.5	27.2	1.3	-5.2
Worrier / anxious feelings	3.0	5.7	11.4	3.4	-0.4
Diabetes diagnosed by doctor	2.9	4.8	7.0	1.6	-2.6
Impedance of leg (right)	2.8	13.3	22.6	2.0	-4.8
Breast cancer (self-reported)	2.8	3.4	3.8	1.9	1.7
Worry (Nagel 2018)	2.7	5.8	10.8	3.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.7	5.8	10.3	-1.1	-3.2
Eye problems/disorders: Glaucoma	2.7	3.2	6.0	-0.7	-2.5
Cholesterol lowering medication	2.7	4.0	7.7	2.8	-0.6
Schizophrenia (2014)	2.6	5.7	10.4	0.9	-3.2
Diabetes (self-reported)	2.6	4.0	4.2	2.0	-2.0
Forced expiratory volume in 1-second (FEV1)	2.6	8.8	13.9	-1.9	-3.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.3	13.0	-1.9	-3.6
Pulse wave reflection index	2.6	3.3	5.5	-1.0	2.4
Bipolar Disorder or Schizophrenia	2.5	6.0	9.6	1.5	-3.1
Neuroticism (Nagel 2018)	2.5	5.8	6.4	2.3	2.5
Crohns Disease (2017)	2.5	5.5	11.0	3.3	-0.2
Pulse rate, automated reading	2.4	7.7	9.3	3.0	-2.5
Medication: Aspirin	2.4	3.1	5.8	-0.6	-2.4
Age started oral contraceptive pill	2.4	3.0	4.2	2.0	1.4
Type 2 Diabetes (T2D) (2018)	2.3	4.3	4.6	2.0	-2.1
Hip circumference	2.3	9.7	18.1	-1.2	4.3
Hair/balding pattern: Pattern 4	2.3	5.6	8.9	3.0	1.5
Peak expiratory flow (PEF)	2.3	5.3	8.1	-2.9	-1.5
Medication: Bendroflumethiazide	2.3	3.5	5.4	2.3	1.3
Medication: Metformin	2.2	3.2	3.5	1.9	-1.7
Nervous feelings	2.2	4.2	6.3	2.5	1.4
Leg pain on walking	2.2	2.8	4.4	-2.1	-1.1
Illnesses of father: None of the above (group 1)	2.2	2.7	5.4	2.3	-0.1
HbA1C	2.1	2.3	4.5	2.1	-0.4
Blood White Count	2.1	15.4	30.1	0.8	-5.5
Average weekly spirits intake	2.1	2.6	4.9	-0.6	2.2
Supplements: Zinc	2.1	2.3	2.4	1.5	-1.6
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.3	1.8	-1.1
Medication: Levothyroxine sodium	2.0	3.3	3.3	-1.8	-1.8
Number of live births	2.0	2.8	5.5	-0.3	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	2.7	1.4	1.6
HDL Cholesterol	1.9	3.1	6.0	-0.6	2.4
Eye problems/disorders: Diabetes related eye disease	1.9	2.1	3.6	1.9	-0.8
Forced vital capacity (FVC)	1.9	7.4	12.1	-1.6	-3.5
Tense / ‘highly strung’	1.9	3.2	6.3	2.5	0.0
Illnesses of father: Heart disease	1.9	2.6	3.7	-1.9	-1.2
Ever had bowel cancer screening	1.9	2.2	4.4	2.1	0.2
Supplements: Calcium	1.9	2.1	3.2	0.9	1.8
Alzheimer’s Disease (in father)	1.8	2.0	2.9	-1.0	1.7
LDL Cholesterol	1.8	2.8	5.4	2.3	0.5
Pack years adult smoking proportion	1.8	2.8	4.1	-1.2	-2.0
Shortness of breath walking on level ground	1.8	2.1	3.6	-0.8	1.9
Angina (self-reported)	1.8	2.4	3.6	-1.1	-1.9
Smoking status: Previous	1.8	2.6	5.2	-2.3	0.2
Crohns Disease (2012)	1.7	2.7	4.8	2.2	-0.8
Glaucoma (self-reported)	1.7	2.0	2.4	-1.2	-1.6
Body mass index (BMI)	1.6	6.9	13.7	-0.3	3.7
Forced vital capacity (FVC), Best measure	1.6	5.7	9.2	-1.5	-3.0
Medication: Aspirin	1.6	2.1	4.2	-0.2	-2.0
Knee pain experienced in last month	1.6	2.5	4.5	-0.7	2.1
Irritable Bowel Disease (IBD)	1.5	3.5	6.9	2.6	-0.2
Waist Hip Ratio (WHR)	1.5	6.7	12.9	3.6	-0.7
Angina	1.5	2.0	3.6	-0.6	-1.9
Leg fat-free mass (left)	1.5	8.0	13.9	-1.4	3.7
Leg predicted mass (left)	1.5	8.1	14.0	-1.5	3.7
Arm fat mass (right)	1.5	6.0	11.9	-0.2	3.5
Osteoporosis (self-reported)	1.5	1.8	2.4	-1.5	-1.1
Medication: Atorvastatin	1.5	1.9	3.1	-1.8	-0.8
Unable to work because of sickness or disability	1.5	2.0	3.6	0.6	-1.9
Depressed Affect (Nagel 2018)	1.4	2.9	5.2	-0.8	2.3
Primary Biliary Cirrhosis	1.4	2.0	3.8	1.9	0.5
Past tobacco smoking	1.4	2.6	5.2	2.3	-0.2
Leg fat-free mass (right)	1.4	7.7	11.6	-1.9	3.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.3	0.2	-1.8
Osteoarthritis (self-reported)	1.4	1.8	2.2	-1.5	1.2
Leg predicted mass (right)	1.4	7.4	11.3	-1.9	3.4
Arm fat mass (left)	1.4	5.5	10.9	-0.5	3.3
Average weekly champagne plus white wine intake	1.4	1.9	2.1	1.3	-1.4
Basal cell carcinoma (self-reported)	1.4	1.6	3.0	1.7	-0.5
Intelligence (Savage-Jansen 2018)	1.3	3.9	7.6	-0.5	-2.8
Fasting Glucose	1.3	1.5	2.5	1.6	0.7
Rheumatoid Arthritis	1.3	1.8	1.8	-1.3	-1.3
Lung FEV1/FVC ratio	1.3	6.8	10.3	-1.8	-3.2
Lung FVC	1.3	6.6	11.8	-1.1	-3.4
Medication: Simvastatin	1.3	1.9	3.7	1.9	0.1
Loneliness, isolation	1.3	1.8	2.6	-1.0	1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.5	-0.8	-1.9
Impedance of whole body	1.3	6.6	12.9	0.6	-3.6
Waist circumference	1.2	4.3	8.5	0.2	2.9
Number of incorrect matches in round	1.2	2.0	3.9	2.0	0.2
Weight	1.2	5.9	10.7	-1.0	3.3
Happiness	1.2	1.5	2.8	-0.5	1.7
Headache pain in last month	1.2	2.0	3.1	-1.0	-1.8
Wheeze or whistling in the chest in last year	1.2	2.1	3.6	0.7	1.9
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.2	-0.9	-1.5
Smoking Status	1.1	2.7	5.2	-2.3	-0.5
Neuroticism	1.1	2.6	3.3	1.4	1.8
Chronotype (morning person)	1.1	2.5	3.5	1.3	1.9
Systolic blood pressure, automated reading	1.1	3.2	5.6	0.9	2.4
Arm fat percentage (right)	1.1	4.4	8.9	0.1	3.0
Prospective memory result	1.1	1.4	2.6	-1.6	0.4
Lung cancer (father)	1.1	1.3	2.7	-0.0	1.6
Exposure to tobacco smoke at home	1.1	1.3	2.1	-0.7	1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	2.8	-1.7	-1.3
Qualifications: nursing, teaching	1.1	1.7	3.3	0.4	1.8
Medication: Gliclazide	1.1	1.3	1.4	-1.1	-1.2
Alcohol drinker status: Previous	1.1	1.3	1.4	-1.0	-1.2
Hand grip strength (left)	1.0	2.5	3.0	-1.4	-1.7
Had menopause	1.0	1.3	1.8	0.8	1.4
Noisy workplace	1.0	1.2	2.1	1.4	0.6
Depression (self-reported)	1.0	1.2	2.0	1.4	0.7
Family relationship satisfaction	1.0	1.3	2.2	0.5	1.5
Mood swings	1.0	1.8	3.1	0.7	1.8
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.0	-1.4	-0.3
Friendships satisfaction	1.0	1.2	2.4	0.2	1.6
Financial situation satisfaction	1.0	1.2	2.4	0.2	1.6
Basal metabolic rate	1.0	5.4	9.0	-1.3	3.0
Risk taking	1.0	1.4	1.5	-1.2	1.2
Pack years of smoking	1.0	1.5	1.8	-1.1	-1.4
BMI	0.9	5.4	9.4	-1.2	3.1
Diabetes (father)	0.9	1.2	2.2	0.3	-1.5
Current tobacco smoking	0.9	1.4	2.0	-0.9	-1.4
Fluid intelligence score	0.9	1.8	3.2	0.6	-1.8
Medication: Omeprazole	0.9	1.1	2.1	0.3	-1.5
Leg fat mass (right)	0.9	3.5	7.0	0.1	2.6
Whole body fat-free mass	0.9	4.9	7.5	-1.5	2.7
Arm fat percentage (left)	0.9	3.4	6.7	-0.3	2.6
Eye problems/disorders: Cataract	0.9	1.1	2.1	-0.2	1.5
Medication: Blood pressure	0.9	1.6	2.2	1.5	1.0
Illnesses of father: High blood pressure	0.9	1.1	1.7	-0.7	-1.3
Diastolic blood pressure, automated reading	0.9	2.7	5.3	0.2	2.3
Mean Putamen Volume	0.8	0.9	1.6	1.3	-0.4
Hair Pigment	0.8	23.8	42.9	6.5	-2.2
Maternal smoking around birth	0.8	1.2	1.8	0.7	1.3
Age when periods started (menarche)	0.8	2.0	2.2	1.5	1.3
Alcohol usually taken with meals	0.8	1.2	1.9	-0.7	1.4
Medication: Ramipril	0.8	1.0	1.8	-0.5	-1.3
Neuroticism score	0.8	1.6	1.8	1.2	1.4
Birth weight	0.8	1.7	3.1	-0.4	-1.8
High blood pressure (siblings)	0.8	1.2	1.4	1.2	1.0
Pulse wave peak to peak time	0.8	0.9	1.2	-0.8	-1.1
Had major operations	0.8	1.0	1.9	-1.4	-0.2
Mineral and other dietary supplements	0.8	1.1	1.4	-0.8	-1.2
Whole body water mass	0.8	4.8	7.7	-1.4	2.8
Ever smoked	0.8	1.4	2.8	-1.7	0.3
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.3	-0.8	-1.1
Myopia	0.8	1.1	1.9	-0.6	1.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.9	-0.1	-1.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.6	-1.3	0.6
Leg fat mass (left)	0.8	3.2	6.4	-0.2	2.5
Alzheimer’s Disease (including proxy)	0.7	1.1	2.1	0.1	1.5
Ovarian Cancer	0.7	0.9	1.2	1.1	-0.8
Lupus	0.7	1.1	2.1	-1.4	-0.3
Triglycerides	0.7	1.2	2.2	1.5	-0.5
High blood pressure	0.7	2.0	2.6	1.6	1.2
Trunk fat mass	0.7	2.9	5.3	-0.7	2.3
Had other major operations	0.7	0.8	1.3	-1.1	-0.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.4	-1.2	0.5
Financial difficulties in last 2 years	0.7	1.0	1.9	-1.4	0.2
Medication: Lansoprazole	0.7	0.8	1.4	-0.4	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.7	-1.7	-0.3
Comparative body size at age 10	0.7	1.8	3.3	-0.6	-1.8
Number of children fathered	0.7	0.8	0.8	0.9	-0.9
Neck or shoulder pain in last month	0.7	1.0	1.8	1.3	-0.5
Whole body fat mass	0.7	2.9	5.8	-0.2	2.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.5	-1.2	-0.2
Miserableness	0.7	1.3	2.6	-1.6	0.1
Pain type(s) experienced in last month: Hip pain	0.7	0.8	0.9	-1.0	-0.9
Neuroticism (2016)	0.6	0.9	1.1	0.8	1.1
Tanning	0.6	7.5	14.9	-3.9	-0.3
Relative age of first facial hair	0.6	1.3	1.5	1.2	1.1
Qualifications: CSEs or equivalent	0.6	0.8	1.5	-1.2	0.3
Multivitamins +/- minerals	0.6	0.8	1.0	0.7	-1.0
Hair/balding pattern: Pattern 2	0.6	0.8	1.5	-1.2	-0.3
Impedance of arm (left)	0.6	2.6	5.2	-0.1	-2.3
Length of working week for main job	0.6	0.7	1.2	1.1	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-0.0	-1.3
Birth weight of first child	0.6	1.1	2.1	-1.4	-0.2
Loud music exposure frequency	0.6	0.7	0.8	0.9	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	0.2	1.1
Arm fat-free mass (right)	0.6	2.9	3.8	-1.4	1.9
Arm fat-free mass (left)	0.6	3.0	4.7	-1.1	2.2
Bipolar Disorder (2018)	0.5	0.8	1.5	0.2	-1.2
Age at First Birth	0.5	0.7	1.5	0.1	1.2
Cardiovascular Disease	0.5	1.6	2.8	1.7	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.0	-1.0	0.4
Medication: Co-codamol	0.5	0.6	1.1	0.3	1.1
Trunk fat percentage	0.5	2.0	3.8	-0.6	1.9
Pain all over the body in last month	0.5	0.6	1.1	-1.0	-0.3
Trunk fat-free mass	0.5	2.8	4.3	-1.1	2.1
Pulse wave Arterial Stiffness index	0.5	0.6	0.9	0.5	1.0
Trunk predicted mass	0.5	3.0	4.6	-1.1	2.2
Breastfed as a baby	0.5	0.6	1.1	-0.3	1.0
Blood clot in the leg (DVT)	0.5	0.6	0.8	-0.9	0.6
Medication: Paracetamol	0.5	0.8	1.5	-0.3	1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	-0.2	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	0.9	0.9	-0.6
Emphysema/chronic bronchitis	0.5	0.6	1.1	1.1	0.2
Medication: Blood pressure	0.5	0.9	1.7	0.1	-1.3
Arm predicted mass (right)	0.5	2.4	2.5	-1.6	1.6
Hypertension (Self-reported)	0.5	1.4	1.5	1.2	1.2
Medication for cholesterol	0.5	0.8	1.3	-1.1	-0.4
Smoking status: Current	0.5	0.7	1.1	-0.6	-1.1
Number of self-reported non-cancer illnesses	0.5	0.8	1.4	0.5	1.2
Ever taken oral contraceptive pill	0.5	0.5	0.9	0.9	-0.3
Number of operations (self-reported)	0.5	0.7	1.3	-1.1	-0.3
Ever depressed for a whole week	0.5	0.6	0.9	-0.5	1.0
Pain experienced in last month	0.5	0.8	1.3	0.6	-1.1
Arm predicted mass (left)	0.5	2.6	4.4	-1.0	2.1
Breast Cancer	0.4	0.9	1.7	-0.4	1.3
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	-0.5	-0.9
Coronary Artery Disease (CAD)	0.4	0.5	0.8	0.3	-0.9
Number of treatments/medications taken	0.4	0.8	1.0	1.0	0.7
Hand grip strength (right)	0.4	1.1	1.5	-1.2	-0.8
High blood pressure (mother)	0.4	0.6	0.9	0.9	0.5
Impedance of arm (right)	0.4	2.0	3.6	0.6	-1.9
Falls in the last year	0.4	0.5	0.8	0.9	0.5
Mouth/teeth dental problems: Dentures	0.4	0.7	1.4	-0.1	1.2
Body fat percentage	0.4	1.5	2.9	-0.2	1.7
Leg fat percentage (right)	0.4	1.4	2.3	0.7	1.5
Health satisfaction	0.4	0.5	0.5	-0.7	0.7
Medication for pain relief, constipation, heartburn	0.4	0.8	1.5	0.1	1.2
Migraine (self-reported)	0.4	0.5	0.7	0.6	0.8
Comparative height size at age 10	0.4	2.0	3.0	-1.7	-1.0
Suffer from ‘nerves’	0.4	0.6	0.8	0.6	0.9
Overall health rating	0.4	0.8	1.5	0.1	1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	1.0	0.2
Illnesses of siblings: Diabetes	0.4	0.5	0.9	0.0	-1.0
Long-standing illness, disability or infirmity	0.4	0.6	1.2	-0.2	1.1
Commuting to job workplace: Walk	0.4	0.5	0.9	-0.1	0.9
Hearing aid user	0.4	0.4	0.9	-0.9	-0.1
Mother’s age at death	0.4	0.5	0.6	-0.7	-0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	0.8	-0.1	-0.9
Prostate Cancer	0.3	0.4	0.5	-0.5	0.7
Heel T-Score	0.3	2.4	4.2	2.0	-0.8
Allergy or Eczema	0.3	0.9	1.5	1.2	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	0.2	-0.9
Medication for hormone replacement therapy	0.3	0.3	0.5	0.7	-0.4
Average weekly fortified wine intake	0.3	0.3	0.6	0.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	1.2	0.2
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	-0.7	0.2
Serious illness, injury or assault to yourself	0.3	0.3	0.4	0.5	0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.3	1.1	0.4
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.8	0.4
Supplements: Glucosamine	0.3	0.3	0.7	0.0	0.8
Medication: Atenolol	0.3	0.4	0.5	0.6	-0.7
Sitting height	0.3	1.9	3.8	-1.9	-0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.5	-0.6	-0.7
Medication: Amlodipine	0.3	0.5	0.5	-0.7	0.6
Number of full brothers	0.3	0.3	0.6	-0.8	-0.1
Eye problems/disorders: None of the above	0.3	0.3	0.4	-0.6	-0.5
Medication: Allopurinol	0.3	0.4	0.6	-0.3	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	0.7	-0.8	-0.2
Leg fat percentage (left)	0.3	1.1	2.1	0.2	1.4
Fractured/broken bones in last 5 years	0.3	0.3	0.4	0.6	0.5
Depression (Nagel 2018)	0.2	0.2	0.3	-0.3	0.6
Bipolar Disorder (2011)	0.2	0.2	0.4	0.6	-0.3
Ulcerative Colitis	0.2	0.3	0.3	-0.6	-0.4
Systolic Blood Pressure	0.2	1.2	2.4	-0.1	1.5
Hypothyroidism (self reported)	0.2	0.5	0.5	-0.7	0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.7	-0.1
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	0.7	-0.1
Vitamin and mineral supplements	0.2	0.3	0.6	-0.8	-0.2
Diabetes (mother)	0.2	0.3	0.5	0.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.4	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.4	0.5	-0.7
Allergy	0.2	0.5	1.0	-1.0	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.5	0.5	-0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.5	0.7	0.3
Mean time to correctly identify matches	0.2	0.4	0.7	0.4	0.8
Chest pain or discomfort	0.2	0.4	0.5	-0.4	-0.7
Age at last live birth	0.2	0.2	0.3	0.6	-0.3
Supplements: Vitamin C	0.2	0.2	0.4	-0.3	-0.6
Commuting to job workplace: Public transport	0.2	0.3	0.4	-0.4	0.6
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.7	-0.8	-0.4
Heart disease (siblings)	0.2	0.2	0.2	0.5	-0.5
Ulcerative Colitis (UC)	0.1	0.2	0.4	0.6	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	0.7	-0.4
Blood Eosinophil Count	0.1	0.8	1.6	0.2	1.3
Height	0.1	1.0	1.9	-1.4	-0.2
Respiratory disease	0.1	0.1	0.3	-0.5	0.0
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.1	0.3	-0.2
Severe depression (siblings)	0.1	0.1	0.2	0.5	0.2
Fed-up feelings	0.1	0.2	0.5	-0.7	0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	0.5	0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.3	-0.2	-0.5
Qualifications: None of the above	0.1	0.2	0.4	0.7	0.0
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.1	0.4
Alcohol intake versus 10 years previously	0.1	0.2	0.2	0.4	0.4
Father’s age at death	0.1	0.1	0.3	0.5	0.0
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	0.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.2	0.4	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	-0.2	-0.4
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.2	-0.4
Standing height	0.1	1.0	1.8	-1.3	-0.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	-0.4	0.5
Gout (self-reported)	0.1	0.1	0.1	-0.1	0.4
Qualifications: College or University degree	0.1	0.3	0.4	0.5	0.6
Medication: Ibuprofen	0.1	0.1	0.2	-0.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.2	-0.5	0.3
Number of full sisters	0.1	0.2	0.3	0.2	-0.5
Back pain experienced in last month	0.1	0.1	0.1	0.2	0.4
Medication: Paracetamol	0.1	0.2	0.3	-0.2	0.6
Medication: Lisinopril	0.1	0.2	0.3	-0.5	-0.2
Alcohol drinker status: Never	0.1	0.1	0.3	-0.0	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.2	-0.4	0.0
Irritability	0.1	0.3	0.3	0.5	0.5
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.0	-0.0
Major Depression (MDD)	0.0	0.1	0.1	0.3	-0.1
Reaction Time	0.0	0.1	0.1	-0.2	0.3
Relative age voice broke	0.0	0.1	0.1	0.2	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.1	-0.2	-0.3
Mouth/teeth dental problems	0.0	0.0	0.1	0.2	-0.2
Illnesses of siblings	0.0	0.0	0.1	-0.3	-0.1
Time employed in main current job	0.0	0.0	0.1	0.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.1	-0.0	-0.3
Asthma	0.0	0.1	0.2	-0.4	0.0
Illnesses of mother	0.0	0.0	0.0	0.2	0.1
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	-0.0	-0.1
Age at first live birth	0.0	0.1	0.1	0.1	0.3
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.2	-0.1
Alcohol intake frequency.	0.0	0.0	0.0	0.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.3	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.0	-0.2	-0.1
Average weekly red wine intake	0.0	0.0	0.1	-0.3	0.1
Asthma (self-reported)	0.0	0.0	0.1	-0.1	0.3
Supplements: Fish oil (including cod liver oil)	0.0	0.1	0.1	-0.0	0.3
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.2	-0.0

Hub : Genes

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Trait associations