Hub : Genes

MKKS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1840 0.0340 1.1e-11 0.134 0.136 0.150 0.152 0.144 5.8e-16 3.1e-16 8.3e-18 4.3e-18 3.6e-17
2 GTEx Adipose Subcutaneous 0.1350 0.0470 3.1e-03 0.000 NA -0.003 NA -0.003 3.1e-01 NA 9.6e-01 NA 9.5e-01
3 GTEx Artery Aorta 0.1410 0.0560 7.9e-03 0.005 NA 0.059 NA -0.002 1.6e-01 NA 3.6e-04 NA 4.1e-01
4 GTEx Artery Tibial 0.1443 0.0529 2.6e-03 0.014 NA 0.030 NA 0.030 2.5e-02 NA 2.1e-03 NA 2.0e-03
5 GTEx Skin Not Sun Exposed Suprapubic 0.2040 0.0670 4.6e-03 -0.005 NA 0.008 NA -0.001 8.6e-01 NA 1.1e-01 NA 3.5e-01
6 GTEx Whole Blood 0.1310 0.0410 2.3e-04 0.072 NA 0.032 NA 0.053 3.8e-07 NA 5.9e-04 NA 1.3e-05
7 ROSMAP Brain Pre-frontal Cortex 0.1545 0.0368 1.3e-06 0.054 0.065 0.078 0.075 0.070 1.6e-07 9.5e-09 3.3e-10 7.2e-10 2.6e-09
8 TCGA Colon Adenocarcinoma 0.0600 0.0390 8.1e-03 -0.002 0.028 0.024 NA 0.010 4.1e-01 9.4e-03 1.5e-02 NA 8.2e-02
9 TCGA Brain Lower Grade Glioma 0.0314 0.0177 3.0e-03 0.019 0.022 0.023 NA 0.019 2.7e-03 1.3e-03 1.2e-03 NA 2.8e-03
10 TCGA Prostate Adenocarcinoma 0.0368 0.0234 6.8e-03 0.033 0.001 0.014 NA 0.016 1.9e-04 2.3e-01 1.3e-02 NA 7.0e-03
11 TCGA Thyroid Carcinoma 0.0410 0.0250 9.1e-03 0.014 0.006 0.005 NA 0.010 1.5e-02 7.7e-02 8.8e-02 NA 3.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.9 1.3 4.2 -1.7 -0.1 0.0 0.8 -0.4 0.2 -1.4 1.6 -1.2 -2.0 -0.9
Bipolar Disorder or Schizophrenia 0.3 0.8 2.4 0.5 -0.7 -1.0 1.6 -1.1 1.1 0.7 -1.0 0.4 0.4 0.4
Depressed Affect (Nagel 2018) 2.0 4.3 8.8 3.0 -2.3 -0.9 -1.9 -1.6 -1.6 2.4 -0.8 2.9 2.8 1.0
Depression (Nagel 2018) 3.7 5.6 15.8 4.0 -0.9 0.2 -0.1 -0.9 1.6 3.2 -3.7 2.8 2.8 1.5
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.3 -1.3 0.3 0.8 -0.6 -0.1 0.7 -1.5 1.4 -1.2 -1.4 -1.1
Neuroticism (Nagel 2018) 1.2 2.7 5.1 2.3 -1.9 1.0 -2.2 -2.2 -1.3 1.5 -0.3 2.0 1.6 -0.0
Schizophrenia (2018) 1.3 2.8 6.8 2.1 -1.1 -0.9 1.3 -1.3 1.2 2.0 -2.6 1.5 2.2 1.2
Schizophrenia vs Biploar Disorder 0.4 0.5 1.6 0.3 -1.0 0.0 -0.8 -0.8 0.5 0.1 -1.3 -0.5 -0.0 -1.0
Worry (Nagel 2018) 0.5 1.0 6.2 0.7 -0.8 1.3 -0.6 -2.5 -0.3 0.1 0.4 0.5 0.4 -0.7
Alzheimer’s Disease (in mother) 1.3 1.5 3.9 -1.0 -1.8 1.4 -0.3 2.0 -0.1 -0.6 -0.0 -1.0 -1.1 -2.0
Alzheimer’s Disease (in father) 0.4 0.4 1.5 -0.2 0.6 -0.1 -0.4 -1.2 -1.1 -0.6 0.5 -0.4 0.1 0.5
Alzheimer’s Disease (including proxy) 0.6 0.9 1.9 -1.0 -1.2 0.1 -1.1 0.9 -0.4 -1.0 0.1 -1.2 -1.0 -1.4
Crohns Disease (2017) 0.3 0.6 1.9 1.4 -0.4 0.9 0.5 -0.4 0.6 0.8 -0.9 1.0 0.7 0.3
Irritable Bowel Disease (IBD) 0.8 1.8 5.2 2.3 -0.2 -0.1 -0.2 0.6 1.4 1.6 -1.9 1.7 1.4 1.0
Ulcerative Colitis (UC) 0.8 1.5 4.3 1.6 0.2 -0.3 -0.2 0.8 2.0 1.5 -2.1 1.2 0.7 0.8
Major Depression (MDD) 0.9 1.1 3.3 1.8 -1.0 -1.1 -0.8 -0.0 -0.4 1.4 -1.0 1.4 0.7 0.5
Reaction Time 0.3 0.6 3.4 0.3 0.7 -0.7 0.2 0.7 1.2 0.6 -1.8 -0.4 0.1 0.2
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.5 -1.1 1.4 1.4 -0.7 1.6 1.0 -1.1 1.0 -0.9 -0.9 0.1
Breast Cancer 0.3 0.7 2.5 0.5 -0.1 0.3 1.6 0.3 1.2 0.9 -0.9 0.8 0.7 0.7
Ovarian Cancer 0.3 0.3 1.6 -0.3 0.6 -0.3 0.0 -1.3 0.4 -0.0 -0.3 -0.4 0.9 -0.6
Prostate Cancer 0.5 0.7 2.7 0.9 0.7 -1.6 -0.4 -0.2 -1.0 0.5 -0.3 0.6 1.3 0.3
Age at First Birth 1.1 1.6 4.5 -0.3 -0.6 1.2 -1.6 -1.0 -2.1 -1.3 1.7 -0.7 -0.5 -1.3
Bipolar Disorder (2011) 1.6 1.5 4.0 1.8 0.0 -0.3 -0.6 -0.5 -0.4 2.0 -0.6 2.0 1.0 1.9
Body Mass Index (BMI) (2010) 0.4 0.5 1.3 -0.7 0.5 -0.0 -0.6 -0.2 -1.1 -1.0 1.2 -0.5 -0.5 -0.3
Coronary Artery Disease (CAD) 0.7 0.8 1.6 0.8 -0.5 -0.9 0.8 0.7 -1.2 0.9 0.7 1.2 0.5 1.3
Crohns Disease (2012) 0.3 0.4 1.4 0.8 -0.8 0.8 0.2 -0.0 0.8 0.4 -1.2 0.5 0.1 0.2
Mean Putamen Volume 0.9 1.1 2.8 -0.5 0.8 1.6 0.8 1.4 1.7 0.0 -0.9 -0.6 -1.3 -0.1
Fasting Glucose 1.0 1.2 2.8 0.8 -0.4 -1.7 1.5 -1.3 1.1 1.1 -1.5 0.5 0.7 0.1
HbA1C 1.3 1.4 8.0 0.2 -0.0 -1.1 -2.8 -1.4 -1.7 -0.2 0.8 0.3 0.7 0.1
HDL Cholesterol 0.2 0.4 1.1 -0.6 1.1 -0.7 1.0 -0.1 0.7 -0.3 -0.1 -0.3 -0.2 0.4
LDL Cholesterol 0.5 0.8 2.4 1.5 -0.3 -1.1 -0.3 0.2 -0.8 1.1 -1.0 1.1 0.7 0.2
Lupus 0.5 0.8 4.1 -0.2 0.9 -0.0 0.6 1.0 -0.1 0.7 1.2 0.7 0.4 2.0
Neuroticism (2016) 0.9 1.2 3.3 1.8 0.5 0.5 -1.5 -0.6 -0.5 1.5 -1.0 1.4 1.2 0.2
Primary Biliary Cirrhosis 0.5 0.7 1.7 -0.7 -1.0 0.9 -1.3 -1.2 0.5 -0.5 -0.2 -0.8 -1.1 -0.6
Rheumatoid Arthritis 0.7 1.0 3.7 -0.1 1.9 0.4 1.9 -0.2 0.1 0.4 0.1 0.5 -0.1 1.8
Schizophrenia (2014) 0.7 1.5 3.6 1.2 -1.7 -1.8 1.2 -0.8 1.0 1.2 -1.9 0.6 0.5 -0.0
Triglycerides 0.3 0.5 1.0 1.0 -0.8 -0.9 -0.8 -0.1 -0.8 0.7 -0.5 0.8 0.1 0.2
Type 2 Diabetes (T2D) (2012) 1.5 1.8 5.1 -1.8 -0.3 2.1 -0.1 1.2 0.3 -1.0 0.1 -1.7 -2.3 -1.3
Ulcerative Colitis 1.1 1.5 2.8 1.4 -1.4 -0.9 -0.1 1.4 1.4 1.3 -1.7 1.3 0.9 1.0
Blood Eosinophil Count 0.5 3.8 11.5 -0.7 -3.2 -1.8 -0.9 -2.5 -2.7 -0.0 3.4 1.2 0.1 0.1
Blood Platelet Count 0.0 0.5 2.5 -0.5 -0.1 0.6 0.3 1.6 0.1 0.5 1.0 0.6 -0.2 0.9
Blood Red Count 0.3 2.8 10.8 1.8 -0.8 -0.8 -1.8 -2.5 1.2 1.2 -3.3 0.2 1.1 -1.1
Blood White Count 0.5 3.5 17.5 0.4 -4.2 -2.1 0.6 -3.0 -1.2 1.1 1.1 1.8 0.4 -0.2
Heel T-Score 0.9 6.8 45.8 -1.0 -6.8 -3.3 -0.7 -0.4 -3.0 0.2 2.2 0.9 0.5 -1.1
BMI 0.8 4.7 11.1 3.3 0.2 -2.7 -1.3 -0.1 0.3 2.4 -1.8 2.6 3.1 2.4
Height 0.2 2.9 6.6 -0.5 2.2 0.5 -2.6 1.6 -2.5 -0.3 2.0 0.8 0.4 2.4
Waist Hip Ratio (WHR) 0.6 2.5 5.7 2.1 -0.8 -1.9 0.1 0.4 -0.1 2.1 -1.4 2.4 2.4 1.1
Systolic Blood Pressure 0.7 3.5 24.8 -0.2 -3.1 -0.5 -1.1 -5.0 -0.6 0.6 0.9 0.3 -0.2 -0.8
Smoking Status 0.5 1.3 2.8 1.1 0.3 -0.2 1.7 -1.5 0.7 1.2 -0.7 1.2 1.4 1.4
Allergy or Eczema 0.3 0.8 2.5 0.5 1.3 1.2 -0.3 0.5 -1.6 -0.4 0.5 0.2 1.0 0.9
Cardiovascular Disease 0.8 2.7 16.8 1.0 -1.8 -1.0 -1.1 -4.1 -0.6 1.3 -0.5 1.4 1.4 0.7
Hypothyroidism (self reported) 0.4 0.9 3.4 0.9 1.0 0.0 0.7 0.9 0.3 0.5 0.7 1.0 0.9 1.8
Respiratory disease 0.2 0.5 1.8 -0.2 -0.0 -1.3 -0.6 0.5 -1.0 -0.7 1.1 0.0 0.0 0.3
Type 2 Diabetes (T2D) (2018) 1.3 2.4 6.8 1.4 -1.6 -1.3 -1.7 -2.6 -0.8 1.9 -0.6 2.1 0.7 1.0
Lung FEV1/FVC ratio 0.2 0.8 2.6 -0.1 0.2 1.6 1.6 0.1 1.5 -0.5 -0.6 -0.7 -0.7 -0.3
Lung FVC 0.3 1.4 3.1 -0.1 1.0 0.8 -1.8 1.4 0.4 -1.2 -1.6 -1.5 0.1 -1.4
Neuroticism 1.2 2.9 6.4 2.5 0.3 1.0 -2.1 -1.7 -1.0 2.0 -0.3 2.5 1.9 1.3
Chronotype (morning person) 0.2 0.6 1.5 -1.2 -0.6 0.4 0.3 0.4 0.3 -0.7 0.4 -1.0 -0.9 -1.2
Hair Pigment 0.1 1.8 8.6 -1.9 0.1 -0.6 0.8 -0.8 -1.4 -1.5 2.9 -0.9 -0.9 0.3
Tanning 0.1 1.5 3.5 1.6 0.2 -1.3 1.2 0.5 0.2 1.9 -1.0 1.5 1.3 1.7
Hand grip strength (left) 0.2 0.6 2.1 -0.6 0.9 1.4 -0.4 1.0 0.3 -0.2 0.6 -0.2 -0.8 1.0
Number of treatments/medications taken 1.7 3.0 10.0 0.7 -1.4 -3.2 -1.4 -0.8 -3.0 0.7 1.2 1.7 1.6 1.3
Average weekly spirits intake 1.8 2.2 7.6 1.5 0.0 -0.8 -0.4 0.2 -2.8 0.9 2.1 1.8 1.8 1.5
Sensitivity / hurt feelings 0.7 1.2 4.6 -0.7 0.3 1.8 -1.5 -0.7 -0.9 -0.7 2.1 -0.0 -1.0 -0.2
Frequency of depressed mood in last 2 weeks 1.1 1.5 3.9 1.6 -0.6 1.0 -0.7 -1.5 1.5 1.3 -2.0 0.9 0.7 0.4
Hearing difficulty/problems: Yes 0.9 1.3 4.6 0.4 0.3 0.9 -0.8 -1.1 0.8 -0.8 -1.9 -1.3 -0.5 -2.1
Relative age of first facial hair 1.0 2.1 5.3 -2.3 0.8 1.7 0.2 0.2 1.4 -1.4 1.0 -1.9 -2.2 -1.2
Other serious medical condition/disability diagnosed by doctor 0.6 0.7 1.5 0.8 0.0 -1.0 -1.0 0.7 -0.5 0.9 -0.1 1.2 1.0 1.2
Ever used hormone-replacement therapy (HRT) 2.5 3.2 8.0 1.9 0.1 -2.8 -2.1 -0.4 -2.8 0.7 1.0 1.9 2.3 0.9
Ever had hysterectomy (womb removed) 0.5 0.6 4.9 -0.4 2.2 0.4 -0.5 -0.1 -0.8 -0.5 0.4 -0.3 -0.3 0.3
Systolic blood pressure, automated reading 1.8 5.2 24.0 -0.7 -2.9 -0.3 -2.6 -4.9 -1.8 -1.2 2.0 -0.9 -1.2 -2.6
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 4.0 1.5 -0.6 -1.0 -0.7 -2.0 -1.6 1.2 0.3 1.6 1.4 0.7
Angina 0.7 1.0 2.8 0.6 -0.9 -1.0 0.9 0.2 -0.1 1.3 -0.3 1.7 0.8 1.6
Medication for hormone replacement therapy 2.0 2.2 4.6 2.1 1.1 -1.6 -1.1 1.2 0.0 1.3 -1.5 1.3 2.1 1.8
Vitamin and mineral supplements 0.6 0.9 1.9 1.4 -1.0 -1.0 0.4 -0.8 0.8 1.0 -0.9 1.2 0.9 0.6
Supplements: Zinc 2.7 3.0 6.9 2.6 0.1 -0.8 -0.3 0.7 -1.6 2.2 -0.9 2.6 2.3 2.0
Medication: Co-codamol 1.6 1.8 8.1 0.5 0.4 0.3 1.4 2.9 1.7 0.6 -2.3 -0.1 0.7 0.6
Medication: Metformin 0.4 0.6 1.5 0.4 -0.9 -0.7 -0.4 -1.2 -1.2 1.0 -0.0 1.0 0.3 0.4
Diabetes (father) 1.6 2.0 7.6 0.4 0.3 -0.6 2.8 -1.2 2.7 1.0 -1.9 -0.1 -0.1 0.5
Diabetes (mother) 0.5 0.7 1.4 0.8 -1.1 -1.1 0.4 -0.7 -0.1 1.2 -0.5 0.9 1.1 0.5
Severe depression (siblings) 0.8 0.9 3.5 0.8 -0.9 -0.6 -0.2 0.4 1.1 1.3 -1.9 0.7 0.5 0.6
Pack years adult smoking proportion 1.6 2.5 8.1 0.5 -2.5 -0.3 1.8 -1.0 2.4 1.4 -2.9 0.3 -0.2 -0.4
Impedance of leg (right) 0.3 1.3 6.1 -1.5 -0.4 0.1 2.5 1.3 0.1 -0.8 1.1 -0.4 -1.4 0.3
Leg fat-free mass (left) 0.4 1.9 5.6 1.6 0.1 -1.3 -2.4 -0.2 -0.3 1.4 -0.5 1.4 1.7 1.8
Trunk fat percentage 1.3 5.0 17.6 2.1 -1.7 -4.2 -0.9 0.6 -2.1 1.9 0.4 2.7 3.1 2.1
Hand grip strength (right) 0.3 0.9 5.5 0.4 -0.1 0.9 -2.3 0.8 -1.4 0.0 0.8 0.5 0.5 0.4
Townsend deprivation index at recruitment 0.7 1.0 4.3 -0.2 -0.3 1.3 -0.2 0.6 2.1 -0.3 -1.2 -1.2 -0.8 -0.7
Current tobacco smoking 0.8 1.3 5.9 0.6 -0.3 -0.2 2.4 -1.0 1.7 0.9 -1.3 0.6 0.5 0.8
Average weekly fortified wine intake 1.7 2.0 4.9 1.8 2.2 -0.9 -0.9 1.5 -0.1 0.9 0.1 1.7 1.4 2.2
Maternal smoking around birth 1.4 2.0 9.7 0.5 2.1 1.2 3.1 1.2 1.1 0.7 -0.2 0.4 0.1 1.8
Fed-up feelings 0.6 1.1 5.4 1.2 -1.4 0.0 -1.6 -2.3 -0.4 0.4 -0.2 0.7 0.3 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 7.6 2.8 -0.1 1.0 -0.8 -0.5 2.1 2.2 -2.7 1.8 1.7 1.1
Relative age voice broke 1.0 1.5 4.2 -1.8 -0.0 0.6 -0.6 -0.1 0.8 -1.6 0.4 -2.0 -1.7 -1.4
Taking other prescription medications 0.6 0.9 2.6 -0.2 -1.5 -1.6 -0.8 -1.1 -1.6 -0.3 1.0 0.1 0.2 0.1
Age when periods started (menarche) 0.7 1.7 6.2 -1.4 0.1 2.5 0.9 0.9 1.2 -0.9 -0.1 -1.5 -2.0 -0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 5.7 0.2 2.4 0.8 -0.6 1.0 0.0 0.1 0.4 0.1 0.3 0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 17.0 1.0 -4.1 -1.6 -1.3 -0.4 -1.7 0.8 -0.2 1.3 1.1 -0.9
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 3.7 0.5 1.6 0.2 0.2 -0.0 0.7 1.3 -0.5 0.9 0.9 1.9
Qualifications: CSEs or equivalent 0.3 0.4 2.4 -0.9 -0.2 1.6 -0.1 0.1 0.1 -0.2 0.1 -0.5 -0.9 -0.1
Serious illness, injury or assault to yourself 0.4 0.4 1.7 0.6 0.3 -1.3 -0.4 0.0 -0.9 -0.3 0.8 0.3 0.8 0.5
High blood pressure 1.0 2.7 14.7 0.5 -1.9 -0.2 -2.3 -3.8 -1.8 0.5 0.7 0.9 1.2 -0.2
Hayfever, allergic rhinitis or eczema 0.5 1.2 3.8 0.5 1.9 1.1 0.3 1.3 -1.2 -0.1 0.7 0.5 0.8 1.7
Multivitamins +/- minerals 0.9 1.1 3.3 -1.3 -0.4 1.0 -1.8 -0.3 -1.0 -1.1 1.0 -1.0 -0.7 -1.1
Stomach or abdominal pain in last month 1.2 1.6 5.2 1.3 1.2 -0.1 1.0 0.3 -0.4 1.7 -0.5 1.7 1.3 2.3
Supplements: Glucosamine 0.8 1.0 4.4 -0.7 2.1 0.4 -1.3 1.2 -0.4 -1.2 0.3 -1.2 -0.2 -0.2
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 5.7 1.0 -0.9 -1.8 0.2 -2.4 -0.5 0.6 0.3 1.2 1.3 0.3
Medication: Atenolol 0.3 0.4 1.8 -0.2 -1.3 -0.1 0.7 -1.0 0.3 0.2 0.5 0.4 -0.5 0.3
Medication: Levothyroxine sodium 0.8 1.3 3.5 1.0 0.9 -1.1 -1.2 0.6 -1.3 0.4 1.3 1.2 0.8 1.9
Sitting height 0.3 1.9 5.3 -1.2 1.9 1.4 -2.3 1.1 -0.7 -0.9 2.0 -0.4 -0.7 1.3
Chronic bronchitis/emphysema (father) 0.6 0.7 3.2 0.5 -1.3 -0.6 0.3 -1.8 0.2 1.2 -0.4 0.9 0.1 -0.0
High blood pressure (mother) 1.4 1.9 6.2 1.2 -1.2 -0.6 -1.5 -2.5 -1.4 1.0 1.0 1.8 0.8 1.3
Body mass index (BMI) 0.9 3.9 9.1 2.7 -0.8 -3.0 -0.8 -0.6 0.2 2.4 -1.9 2.2 2.8 1.5
Impedance of leg (left) 0.3 1.6 7.3 -1.9 -0.2 0.2 2.7 0.8 -0.2 -1.2 1.4 -0.7 -1.4 0.1
Leg predicted mass (left) 0.4 2.0 6.0 1.6 -0.0 -1.3 -2.4 -0.3 -0.3 1.5 -0.6 1.5 1.8 1.7
Trunk fat mass 1.1 4.6 15.0 2.1 -1.2 -3.9 -1.0 0.6 -1.5 2.0 -0.0 2.6 3.0 2.4
Waist circumference 1.2 4.6 10.6 2.6 -1.1 -3.3 -1.1 -0.2 0.0 2.8 -1.6 2.8 2.8 2.2
Number of incorrect matches in round 0.7 1.2 5.6 -0.1 1.5 0.6 0.9 2.4 0.0 1.0 0.5 0.8 0.0 1.7
Past tobacco smoking 0.6 1.1 5.0 -0.0 0.2 -0.4 1.2 -0.2 2.0 0.6 -2.2 -0.6 -0.8 -0.2
Alcohol usually taken with meals 0.3 0.5 3.0 -0.4 0.5 -0.2 -1.0 0.1 -0.8 -0.8 1.7 -0.3 -0.1 -0.2
Nervous feelings 0.7 1.3 11.8 0.4 -0.6 0.6 -0.6 -3.4 -0.2 0.2 0.3 0.2 0.1 -1.1
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 5.8 1.4 0.8 1.5 -0.7 -0.0 2.0 1.2 -2.4 0.4 0.6 0.7
Hearing difficulty/problems with background noise 0.2 0.4 1.1 0.9 0.1 -0.2 -0.9 -0.4 -0.3 0.1 -1.0 0.2 0.5 -0.8
Hair/balding pattern: Pattern 2 0.7 0.9 2.7 0.8 0.7 0.4 0.7 1.2 1.5 0.9 -1.6 0.3 -0.3 0.5
Had menopause 1.0 1.3 5.6 0.3 1.5 -1.5 -2.4 -0.0 -1.3 0.3 0.6 0.7 0.3 1.2
Had other major operations 0.3 0.4 2.2 0.1 1.5 0.7 0.9 0.0 -0.2 0.1 -0.6 -0.2 0.1 0.1
Forced vital capacity (FVC) 0.3 1.3 4.7 -1.2 1.6 2.2 -0.8 1.2 0.2 -1.3 0.3 -1.3 -0.8 -0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 22.6 0.4 -4.8 -1.0 -0.7 -0.4 -1.6 0.6 0.0 1.1 0.5 -1.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.6 0.7 -1.3 -0.6 0.8 -1.2 0.1 0.5 -1.1 0.5 0.6 -0.6
Qualifications: None of the above 0.6 1.2 3.2 1.3 -1.4 0.1 1.6 -0.0 0.1 1.2 -1.8 0.9 1.2 0.4
Financial difficulties in last 2 years 0.5 0.7 3.6 0.6 -0.8 1.1 0.1 -0.4 1.9 0.0 -1.3 -0.4 -0.0 -0.5
Mouth/teeth dental problems 0.5 0.8 2.3 -0.9 1.5 -0.0 0.9 0.8 1.5 -0.3 0.4 -0.7 -1.3 0.0
Heart attack 0.9 1.1 2.7 1.1 -1.6 -0.2 -1.0 0.5 -1.0 1.1 -0.1 1.6 0.8 1.1
Allergy 0.5 1.2 3.8 -0.8 -1.8 0.0 0.3 -2.0 0.9 -0.4 -0.1 -0.6 -0.9 -1.7
Pain all over the body in last month 2.6 2.7 5.5 1.0 -0.0 0.1 1.4 1.9 2.3 2.3 -2.4 1.4 1.3 2.0
Diabetes (self-reported) 1.7 2.7 4.7 1.4 -2.0 -1.3 -2.0 -2.2 -2.0 1.6 0.3 2.1 1.1 0.8
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 4.2 -1.5 0.6 1.7 -1.0 1.4 -1.4 -2.1 1.6 -1.7 -1.1 -1.5
Medication: Ramipril 1.1 1.4 3.2 -1.7 -1.8 0.9 0.8 -0.8 0.1 -1.1 1.4 -1.0 -1.2 -1.2
Medication: Simvastatin 0.4 0.6 1.3 0.8 -0.4 -1.1 -0.0 -0.4 -1.0 0.8 0.1 1.1 0.8 0.5
Fluid intelligence score 1.7 3.5 6.9 -2.3 1.3 2.6 -0.4 2.0 1.7 -2.1 1.1 -2.2 -2.6 -0.5
Illnesses of siblings 0.8 1.2 5.0 0.7 1.4 0.5 0.7 1.3 2.2 0.7 -1.7 0.0 0.1 0.4
Neuroticism score 0.9 1.9 6.3 1.8 -0.5 0.8 -1.9 -2.5 -0.3 1.5 -0.5 1.7 1.3 0.2
Weight 0.6 3.0 6.3 2.0 -0.0 -2.5 -1.8 0.0 -0.7 2.0 -0.6 2.1 2.3 2.2
Impedance of arm (right) 0.3 1.4 4.9 -0.9 -0.0 -0.3 1.2 2.0 -1.8 -0.5 2.2 0.4 -0.2 0.8
Arm fat percentage (right) 1.3 5.2 16.9 2.8 -1.3 -4.1 -0.3 0.5 -0.8 2.5 -0.9 2.8 3.4 1.9
Trunk fat-free mass 0.2 1.1 3.4 0.9 1.5 -0.1 -1.9 0.0 0.6 1.1 -0.8 0.7 0.7 1.5
Hip circumference 0.5 2.1 6.0 1.5 -0.4 -2.5 -1.1 -0.4 0.1 1.7 -0.8 1.6 1.7 2.1
Time employed in main current job 0.7 0.8 4.0 -0.4 -0.3 1.1 1.7 -2.0 0.1 0.2 0.2 0.0 -0.8 -0.1
Alcohol intake versus 10 years previously 0.6 1.0 2.7 1.1 -1.4 -1.6 -0.1 -0.9 -0.9 1.0 -0.2 1.1 0.8 0.2
Father’s age at death 2.3 3.1 7.3 -2.2 2.7 1.6 -0.7 1.6 0.6 -2.0 1.1 -2.1 -2.4 -0.2
Worrier / anxious feelings 0.5 0.9 5.1 -0.0 -0.1 1.7 -0.2 -2.2 -0.4 -0.3 1.0 0.1 -0.2 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 2.6 1.4 0.5 1.1 0.2 0.0 1.3 1.3 -1.6 1.3 1.3 1.5
Falls in the last year 0.2 0.3 1.3 0.1 1.1 -0.5 -0.4 0.3 -0.4 0.4 0.4 0.1 -0.1 1.0
Hair/balding pattern: Pattern 3 1.0 1.4 3.6 -1.3 1.2 1.4 0.3 1.9 -1.2 -1.0 1.9 -0.5 -0.5 0.8
Number of live births 0.6 0.8 2.2 -0.1 1.3 -0.0 0.7 -1.3 1.5 -0.5 -1.3 -0.9 -0.0 0.0
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 7.7 -1.4 1.3 2.8 -0.2 1.0 0.8 -1.5 -0.0 -1.7 -1.3 -0.8
Pulse rate 0.1 0.2 0.4 0.6 0.0 -0.3 0.4 -0.7 0.5 0.6 -0.3 0.3 0.2 -0.1
Happiness 0.7 0.8 2.5 -0.8 -0.5 1.1 1.5 0.2 1.6 -0.4 -0.0 -0.7 -1.0 -0.7
Noisy workplace 0.2 0.3 0.7 -0.6 -0.2 -0.2 0.4 0.3 0.7 -0.8 -0.1 -0.8 -0.5 -0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.8 4.3 -1.6 0.0 -0.2 -2.1 -0.1 -0.7 -1.8 2.0 -1.4 -1.3 -1.5
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.1 -0.3 -0.2 0.4 -0.9 0.7 0.2 -0.9 -0.2 -1.1 -0.6 -0.7
Mouth/teeth dental problems: Dentures 0.3 0.5 2.8 -0.2 -0.8 -0.2 -0.8 -0.7 -1.7 0.0 0.7 0.6 0.3 0.3
Asthma 0.4 0.7 4.3 0.0 -0.0 -2.1 -1.4 -0.5 -0.8 -0.5 0.8 0.0 -0.1 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.8 -0.5 -0.8 -0.3 1.3 -1.0 -1.9 -0.3 1.8 0.5 -0.1 0.4
Medication: Cholesterol lowering 0.7 1.2 4.6 -0.5 -2.1 -1.6 -0.7 -0.1 -1.5 -0.2 1.5 0.4 -0.3 -0.3
Depression (self-reported) 1.2 1.4 3.4 1.7 -0.3 -1.8 -0.9 -0.4 -1.1 1.4 -0.2 1.7 1.0 1.2
Medication: Lansoprazole 0.2 0.2 1.0 0.0 0.3 -0.3 -0.1 -1.0 -0.1 0.1 0.2 0.3 0.7 0.5
Prospective memory result 0.6 0.7 2.2 0.5 -0.5 -1.5 1.5 -0.3 -0.1 1.1 -1.1 0.5 0.9 0.1
Lung cancer (father) 1.0 1.2 2.9 -1.6 -0.2 1.1 1.7 -0.2 0.9 -1.1 -0.2 -1.4 -1.4 -0.7
Illnesses of mother 1.7 2.0 3.9 -1.6 0.7 1.8 1.1 2.0 0.6 -1.6 0.4 -1.9 -1.5 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 6.3 -0.8 1.6 2.5 -0.5 1.2 0.9 -1.1 -0.8 -1.5 -0.8 -0.4
Pulse wave Arterial Stiffness index 1.0 1.2 2.9 0.5 1.6 0.4 0.5 1.7 1.3 0.9 -1.1 0.5 0.4 1.6
Impedance of arm (left) 0.4 1.9 8.7 -1.0 -0.7 -0.7 0.3 1.4 -2.6 -0.7 2.9 0.4 -0.1 0.5
Arm fat mass (right) 1.1 4.5 12.1 2.6 -0.7 -3.5 -0.9 0.3 -0.5 2.5 -1.0 2.6 3.1 2.2
Trunk predicted mass 0.2 1.0 3.1 0.9 1.5 -0.1 -1.8 -0.0 0.7 1.0 -0.9 0.6 0.6 1.5
Standing height 0.3 2.6 6.6 -1.5 2.0 1.2 -2.2 1.5 -1.6 -0.9 2.6 -0.3 -1.1 1.7
Length of working week for main job 0.9 1.0 3.6 0.6 0.7 -0.3 0.4 1.9 1.0 0.9 -1.3 0.6 0.9 1.3
Exposure to tobacco smoke at home 0.9 1.0 5.1 -0.1 -2.3 0.5 -1.2 -0.1 0.5 0.1 -1.3 -0.7 -0.1 -1.2
Breastfed as a baby 1.7 2.1 4.7 -1.9 0.6 -0.0 -1.6 1.1 -0.7 -2.1 2.2 -1.7 -1.5 -1.3
Tense / ‘highly strung’ 1.8 3.0 9.8 0.7 -2.0 2.0 -3.1 -2.8 -1.8 -0.0 0.8 0.4 0.3 -1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.3 3.4 1.8 0.0 -1.0 -0.3 -0.5 -1.5 0.7 0.0 1.5 1.6 1.3
Hair/balding pattern: Pattern 4 0.1 0.3 0.9 0.5 -0.4 0.0 -0.8 -0.7 0.2 0.2 -0.9 0.3 0.9 -0.2
Birth weight of first child 0.3 0.6 1.2 -0.9 1.0 0.8 0.8 -0.4 -0.0 -0.5 -0.3 -1.0 -1.1 -1.0
Peak expiratory flow (PEF) 0.3 0.6 1.4 -0.9 1.2 0.9 -0.6 0.9 -0.0 -1.0 0.6 -1.1 -0.6 -0.1
Pulse wave reflection index 2.2 2.7 12.6 0.2 1.6 0.6 1.6 -0.0 3.5 1.1 -3.0 -0.4 -0.3 0.8
Ever highly irritable/argumentative for 2 days 4.3 5.2 12.2 2.5 -1.0 -1.6 2.8 1.3 1.6 3.1 -3.5 2.4 2.1 1.9
Loud music exposure frequency 1.0 1.0 5.0 0.1 1.0 0.2 2.2 0.1 1.5 0.3 -1.5 0.0 0.2 0.8
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 4.7 -1.9 0.5 1.9 -1.4 0.2 0.2 -2.0 1.3 -2.1 -2.2 -1.9
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 8.9 1.5 -3.0 -0.5 -0.8 -1.4 -0.4 1.0 -1.3 1.0 1.5 -0.4
Blood clot in the leg (DVT) 0.3 0.4 1.0 0.5 0.3 0.9 -0.9 0.8 -1.0 0.4 0.4 0.4 0.3 0.3
Medication: Paracetamol 1.0 1.7 3.7 1.8 -1.3 -1.9 -0.2 -0.2 -1.4 1.3 -0.8 1.7 1.6 0.2
Headache pain in last month 0.7 1.2 2.8 1.7 0.2 0.9 -0.5 -1.1 -1.1 1.3 -0.7 1.4 1.2 1.0
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 5.7 0.4 2.4 0.8 0.7 1.4 0.9 -0.1 -1.1 -0.4 -0.3 0.2
Glaucoma (self-reported) 0.2 0.3 1.3 -0.8 0.3 0.1 0.9 -0.0 0.1 0.1 0.3 0.1 -0.1 1.1
Gout (self-reported) 0.4 0.5 2.9 0.0 0.6 0.5 0.1 0.2 0.1 0.6 0.5 0.8 0.7 1.7
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.9 0.6 0.8 -0.2 -0.4 0.7 -0.3 0.2 0.9 0.7 0.6 1.4
Medication: Amlodipine 3.5 4.9 12.1 1.7 -3.3 -2.5 -2.0 -3.5 -2.6 1.4 0.1 1.9 2.2 -0.2
Medication: Ventolin 100micrograms inhaler 1.8 2.4 5.5 -1.3 -1.7 -1.3 -0.5 -0.9 -1.8 -2.1 2.3 -1.0 -0.9 -1.9
Birth weight 0.4 0.8 5.7 0.4 2.4 0.4 -1.0 -0.0 0.3 0.4 -0.6 -0.1 0.5 1.2
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.9 0.4 0.8 -1.3 1.3 1.7 -0.4 0.4 0.0 0.5 0.4 1.1
High blood pressure (siblings) 1.2 1.7 6.7 -1.5 -1.1 0.5 0.0 -2.6 -0.8 -1.1 1.9 -0.7 -1.2 -0.5
Forced vital capacity (FVC), Best measure 0.3 1.2 4.6 -0.7 1.7 2.1 -1.4 1.1 0.1 -1.1 -0.2 -1.2 -0.4 0.0
Body fat percentage 1.2 4.6 17.6 2.1 -1.7 -4.2 -0.4 0.4 -1.5 2.0 -0.1 2.6 3.0 2.0
Leg fat percentage (right) 1.1 3.9 16.1 2.2 -1.5 -4.0 0.2 0.1 -0.3 2.1 -1.1 2.4 2.3 1.9
Arm fat-free mass (right) 0.2 1.2 5.7 1.0 0.5 -0.6 -2.4 -0.6 0.4 1.1 -0.8 0.8 0.8 1.3
Exposure to tobacco smoke outside home 1.5 2.0 4.3 1.8 1.4 0.3 0.8 -0.9 1.3 2.1 -1.9 1.3 1.4 1.6
Comparative body size at age 10 1.6 4.3 11.2 2.5 1.4 -2.2 1.7 0.3 1.8 2.7 -3.3 1.5 2.5 1.2
Number of full brothers 0.8 1.0 2.6 1.2 -0.9 -1.0 -0.6 -1.6 -1.2 0.8 -0.0 1.2 0.8 0.9
Worry too long after embarrassment 1.1 1.9 12.4 0.5 -0.3 3.5 -1.6 -1.9 -0.6 -0.0 0.4 0.3 -0.2 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.9 2.0 0.5 -0.2 -0.2 0.3 0.7 1.5 -1.3 1.5 1.1 1.6
Wheeze or whistling in the chest in last year 1.5 2.6 8.5 1.7 0.2 -2.9 -0.2 -0.3 -1.1 2.0 -0.2 2.3 1.8 1.8
Number of children fathered 0.6 0.7 1.8 -0.7 0.1 0.3 -1.3 0.7 -1.3 -0.7 0.5 -0.8 -0.3 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 2.1 -0.4 0.9 0.5 -0.7 -1.5 0.9 -0.0 -0.1 -0.3 0.0 -0.1
Age at first live birth 0.9 1.7 4.0 -1.5 -0.3 1.1 -1.5 -0.5 -0.6 -1.6 1.4 -1.5 -1.2 -2.0
Pulse wave peak to peak time 0.7 0.9 1.8 -0.5 -1.3 -0.3 -0.5 -1.3 -1.3 -0.8 1.2 -0.3 -0.3 -1.1
Health satisfaction 0.5 0.6 1.5 0.0 -1.1 -1.2 1.2 -0.2 1.1 0.6 -1.0 0.1 0.2 -0.1
Shortness of breath walking on level ground 2.3 2.8 8.5 1.3 0.0 -2.1 1.9 0.5 -0.2 1.9 -0.3 2.2 1.7 2.9
Qualifications: College or University degree 0.3 1.0 2.8 -1.4 1.5 0.6 -1.0 0.2 0.9 -0.5 1.7 -0.7 -0.9 0.3
Eye problems/disorders: None of the above 1.5 1.7 6.1 -0.5 1.2 2.1 2.5 0.8 2.1 -0.2 -1.1 -0.7 -0.4 0.2
Mouth/teeth dental problems: Loose teeth 0.9 1.0 5.2 -0.1 -2.3 -0.6 -0.5 0.4 0.1 -0.7 -0.9 -0.8 -0.1 -1.9
Emphysema/chronic bronchitis 0.7 0.8 1.4 0.8 0.7 -1.0 0.7 0.1 1.1 0.9 -1.1 0.7 1.1 1.2
Medication for pain relief, constipation, heartburn 0.8 1.4 3.5 -0.9 1.1 1.7 0.1 0.9 1.9 -0.9 -0.7 -1.7 -1.2 -0.8
Neck or shoulder pain in last month 1.2 1.7 4.5 1.7 -0.4 -1.0 -0.3 0.6 -0.7 2.1 -1.3 1.8 1.8 1.2
Medication: Blood pressure 0.6 1.1 5.1 -0.5 -2.3 -0.6 -0.7 -1.9 -0.9 0.3 1.1 0.4 0.3 -0.1
Angina (self-reported) 0.5 0.7 2.0 0.4 -1.0 -0.9 0.9 0.2 -0.0 1.0 -0.3 1.4 0.7 1.2
Migraine (self-reported) 1.8 2.2 6.6 -0.2 -2.5 1.0 -1.0 -1.8 1.1 -1.1 -1.2 -1.4 -0.8 -2.6
Medication: Ibuprofen 0.6 0.7 2.0 -0.3 -0.4 0.3 1.2 -0.8 -1.4 0.1 1.3 0.7 -0.1 0.9
Medication: Allopurinol 0.3 0.3 1.1 -0.2 0.3 0.8 0.6 -0.2 0.9 0.5 -0.3 0.4 0.3 1.1
Medication: Omeprazole 0.5 0.7 2.2 0.8 0.4 -0.1 0.7 0.5 0.5 0.8 -0.7 0.8 1.2 1.5
Medication: Seretide 50 evohaler 1.4 1.6 3.6 1.1 -0.6 -1.2 0.5 -1.4 -1.5 0.7 1.4 1.9 1.5 1.2
Mean time to correctly identify matches 0.3 0.6 1.3 -0.6 1.1 0.3 0.2 1.1 1.1 0.2 -1.0 -0.8 -0.7 0.2
Heart disease (mother) 2.8 3.4 8.6 2.3 -0.1 -1.7 -0.4 -1.3 -1.5 2.2 0.7 2.9 2.7 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 5.9 0.6 1.5 -0.0 2.4 1.3 0.8 0.9 0.5 1.1 0.6 1.8
Whole body fat mass 1.1 4.5 14.5 2.2 -1.0 -3.8 -0.8 0.5 -1.3 2.2 -0.3 2.7 3.0 2.4
Leg fat mass (right) 0.9 3.6 12.7 2.1 -1.3 -3.6 -0.3 0.1 -0.2 2.1 -1.2 2.2 2.5 1.9
Arm predicted mass (right) 0.3 1.3 6.5 1.2 0.5 -0.6 -2.5 -0.7 0.2 1.1 -0.8 1.0 1.0 1.3
Pulse rate, automated reading 0.1 0.2 0.6 0.2 0.4 0.7 -0.1 -0.5 0.1 -0.5 0.1 -0.4 0.2 -0.8
Alcohol intake frequency. 0.6 1.4 4.2 1.5 -1.6 -0.9 -0.0 -1.6 0.7 1.3 -2.1 0.8 0.6 0.1
Comparative height size at age 10 0.5 3.0 11.8 0.7 2.3 -0.3 -1.4 2.6 -0.8 1.1 0.8 1.7 1.0 3.4
Number of full sisters 0.8 1.0 3.5 0.9 -1.4 0.8 0.8 0.1 1.0 1.3 -1.9 0.9 0.7 0.3
Suffer from ‘nerves’ 0.4 0.6 2.4 0.8 1.0 0.5 -0.8 -1.6 0.9 0.2 -0.7 0.2 0.2 0.1
Overall health rating 0.4 0.9 2.4 0.7 -0.3 0.1 1.3 -1.5 1.3 0.4 -1.5 0.2 0.4 0.7
Chest pain or discomfort 0.8 1.2 3.1 1.0 -0.3 1.1 0.2 0.0 0.4 1.4 -0.3 1.6 1.6 1.8
Had major operations 1.6 1.9 4.2 -1.9 0.4 1.1 -0.2 0.9 0.2 -1.9 1.2 -2.0 -1.8 -1.6
Age at last live birth 0.4 0.6 2.0 -0.9 0.0 0.5 -0.4 -0.8 0.5 -1.0 0.6 -1.1 -0.7 -1.4
Family relationship satisfaction 0.7 0.8 1.9 -1.0 -1.1 0.8 -0.3 -0.4 0.1 -0.9 0.8 -1.2 -1.1 -1.4
Leg pain on walking 0.6 0.7 3.9 0.1 -2.0 0.4 1.4 0.2 -1.0 -0.2 0.7 0.3 0.3 -0.5
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.3 0.8 -1.0 -1.1 -0.5 -0.5 -0.7 -0.2 -0.5 0.1 0.4 -0.9
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.1 -0.7 0.5 0.3 1.8 1.6 0.5 -0.3 0.8 -0.1 -0.6 0.5
Illness, injury, bereavement, stress in last 2 years 0.4 0.4 1.8 -0.3 0.7 -0.3 0.9 -1.3 -0.6 0.5 0.6 0.5 0.0 0.6
Medication: Aspirin 0.4 0.6 2.9 -0.5 -0.1 -0.7 -1.7 -0.1 -0.9 -0.5 1.1 0.1 -0.1 0.4
Supplements: Vitamin C 0.6 0.8 2.5 -0.6 1.5 -0.5 0.4 1.6 -0.9 -0.7 0.5 -0.7 -0.4 0.6
Knee pain experienced in last month 0.3 0.5 1.6 -0.4 -1.3 0.5 0.1 -0.4 0.5 -0.1 -1.0 -0.5 -0.6 -1.1
Hypertension (Self-reported) 0.8 2.3 14.3 0.5 -1.7 -0.2 -1.8 -3.8 -1.5 0.4 0.7 0.8 1.0 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.6 1.0 0.5 0.5 -0.7 -0.9 0.1 1.0 -0.6 0.9 0.7 1.3
Illnesses of father: Heart disease 0.5 0.8 1.8 1.2 0.5 -0.6 0.1 -0.7 -0.2 1.3 -0.1 1.3 1.2 1.0
Illnesses of siblings: Diabetes 0.7 0.9 3.9 0.2 -1.0 -0.9 -0.8 -0.4 -2.0 -0.5 1.4 0.4 0.6 -0.4
Smoking status: Previous 1.1 1.7 7.8 -0.8 -0.1 0.4 -1.5 -0.2 -2.7 -0.9 2.8 0.2 0.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 5.3 -0.2 1.6 2.0 0.6 1.9 1.3 0.8 0.1 0.6 0.2 2.3
Whole body fat-free mass 0.2 1.4 5.0 1.2 0.9 -0.7 -2.2 -0.1 0.2 1.3 -0.8 1.0 1.1 1.6
Leg fat-free mass (right) 0.3 1.5 5.7 1.3 0.3 -1.0 -2.4 -0.4 -0.4 1.2 -0.3 1.2 1.6 1.5
Arm fat percentage (left) 1.2 4.9 17.3 2.6 -1.5 -4.2 -0.6 0.3 -1.0 2.3 -0.5 2.7 3.3 1.7
Average weekly red wine intake 1.2 1.7 10.2 0.5 2.2 0.6 -3.2 -0.0 -0.7 -1.1 1.1 -0.2 0.3 -0.1
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.0 1.4 0.2 0.3 0.7 0.3 1.2 1.3 -1.2 1.1 0.8 0.6
Mood swings 1.3 2.4 5.7 2.4 -0.5 -0.1 -0.0 -2.1 -0.8 2.1 -1.5 2.0 1.9 0.5
Loneliness, isolation 0.8 1.1 6.4 0.9 -1.2 1.1 -2.5 -0.8 -0.9 -0.0 -0.1 0.5 0.3 -0.3
Long-standing illness, disability or infirmity 2.2 3.4 7.3 2.7 -0.8 -2.3 -2.0 -1.3 -0.8 2.3 -1.6 2.1 2.1 1.2
Ever had bowel cancer screening 0.4 0.5 2.2 -0.2 1.5 -0.5 0.4 0.9 -0.5 0.5 0.5 0.3 0.1 1.1
Diabetes diagnosed by doctor 0.9 1.5 5.8 0.4 -1.7 -0.6 -1.2 -2.4 -1.4 1.0 0.5 1.4 0.1 0.5
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 3.7 -0.8 0.5 0.9 -1.1 -1.2 0.5 -1.5 -0.1 -1.7 -1.1 -1.9
Friendships satisfaction 0.4 0.5 1.6 0.1 -1.3 -0.8 -0.6 -0.1 -1.3 -0.1 0.8 -0.0 -0.0 -0.7
Qualifications: nursing, teaching 0.3 0.5 2.0 0.6 1.4 -0.6 -1.2 -0.2 -0.6 -0.3 -0.1 0.2 0.8 -0.4
Commuting to job workplace: Walk 0.7 0.8 2.0 -1.1 -0.7 0.3 0.4 -1.4 -0.5 -1.2 0.9 -0.9 -0.3 -1.1
Eye problems/disorders: Cataract 0.4 0.5 1.4 -0.0 -0.6 -1.1 -1.2 -1.2 -0.4 -0.2 0.7 -0.0 -0.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 2.0 3.2 7.8 2.5 1.2 -0.4 0.6 0.7 -1.6 1.9 -1.1 2.4 2.8 2.3
Medication for cholesterol 1.4 2.1 4.4 -2.1 -0.3 2.0 1.3 0.8 0.5 -1.4 1.3 -1.7 -2.0 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 3.3 1.0 1.0 -1.8 -0.6 0.3 0.4 0.8 -0.6 0.6 1.5 1.0
Back pain experienced in last month 2.0 2.9 8.7 -0.3 -2.6 0.6 -2.8 -3.0 -1.5 -0.9 0.6 -0.8 -0.5 -2.0
Mineral and other dietary supplements 0.8 1.1 2.7 0.1 -1.6 1.3 1.3 -1.2 1.4 -0.3 -1.0 -0.5 -0.2 -1.2
Breast cancer (self-reported) 0.7 0.9 2.7 -0.5 1.1 0.0 1.2 1.6 -1.4 -0.4 1.2 0.1 0.6 0.4
Asthma (self-reported) 0.4 0.7 4.0 -0.2 -0.2 -2.0 -1.1 -0.5 -0.8 -0.7 1.0 -0.1 -0.2 -0.3
Osteoporosis (self-reported) 0.3 0.3 0.6 -0.6 0.7 -0.3 -0.7 -0.5 0.7 -0.5 -0.2 -0.7 -0.7 -0.5
Osteoarthritis (self-reported) 0.4 0.6 2.5 -0.4 1.1 0.1 1.6 1.0 -0.2 0.2 0.6 0.1 -0.7 0.9
Medication: Aspirin 0.5 0.6 3.1 -0.5 -0.3 -0.7 -1.7 -0.2 -1.0 -0.3 1.3 0.2 -0.2 0.5
Medication: Gliclazide 0.8 0.9 1.9 1.2 -0.4 -0.8 -0.6 -1.1 -1.1 1.1 -0.5 1.1 1.4 0.2
Illnesses of father: None of the above (group 1) 1.2 1.5 7.6 -0.6 0.9 1.4 1.1 2.8 1.1 -1.0 -0.2 -0.9 -0.9 -0.5
Smoking status: Current 0.9 1.4 5.4 1.0 -0.1 -0.7 2.3 -0.8 1.4 1.1 -1.2 0.9 1.0 1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 2.1 0.5 0.7 1.1 -1.2 0.5 0.6 0.5 -1.5 0.2 0.9 -0.3
Whole body water mass 0.2 1.4 4.6 1.3 0.8 -0.6 -2.1 -0.1 0.2 1.3 -0.9 1.1 1.2 1.6
Leg predicted mass (right) 0.3 1.5 5.4 1.3 0.3 -1.1 -2.3 -0.5 -0.4 1.2 -0.3 1.2 1.6 1.5
Arm fat mass (left) 1.1 4.6 12.8 2.7 -0.7 -3.6 -1.1 0.2 -0.7 2.5 -0.9 2.7 3.2 2.1
Number of self-reported non-cancer illnesses 0.8 1.3 4.3 0.5 -0.8 -2.1 -0.0 -1.2 -1.5 0.7 0.3 1.3 1.1 1.5
Average weekly champagne plus white wine intake 0.3 0.4 0.9 0.6 0.6 -0.1 0.9 0.9 0.5 0.6 -0.4 0.5 1.0 0.6
Miserableness 1.1 1.9 4.7 2.2 -0.7 0.3 -1.4 -1.3 -0.1 1.8 -1.3 2.1 1.6 0.9
Guilty feelings 1.0 1.5 4.3 1.4 -1.5 -0.4 -1.3 -2.1 0.3 0.9 -1.9 0.6 1.2 -0.7
Wears glasses or contact lenses 3.5 4.0 8.8 -2.8 0.6 1.3 -1.0 -0.1 -1.8 -3.0 2.7 -2.2 -2.4 -1.8
Ever taken oral contraceptive pill 0.3 0.4 0.9 -0.4 -0.3 0.9 0.4 1.0 0.8 -0.6 -0.8 -0.6 -0.1 -0.3
Hearing aid user 2.2 2.5 5.3 -2.2 0.7 2.1 -1.1 0.0 1.3 -1.7 0.7 -2.1 -2.3 -1.3
Mother’s age at death 1.2 1.5 5.6 0.7 2.3 -0.3 -2.4 0.3 -1.4 -0.0 1.1 0.5 0.5 1.0
Financial situation satisfaction 0.4 0.6 2.0 1.4 -0.4 -0.2 -0.2 0.9 0.4 0.7 -1.1 0.6 0.8 0.4
Tinnitus: Yes, now most or all of the time 1.5 1.7 4.7 1.6 0.7 -0.7 0.3 -0.7 1.5 2.2 -1.8 1.6 0.8 1.3
Commuting to job workplace: Public transport 2.3 2.8 9.6 -1.2 -1.1 1.0 -2.2 -1.7 0.7 -1.4 -0.7 -2.0 -1.4 -3.1
Eye problems/disorders: Glaucoma 0.4 0.5 1.3 -0.9 -0.0 -0.3 -0.5 -1.1 -1.1 -0.8 1.1 -0.2 -0.3 0.1
Medication: Blood pressure 1.0 1.9 4.9 1.8 -0.3 -0.8 -1.3 -2.2 -0.2 1.3 -1.1 1.8 1.9 0.9
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.9 -0.0 -0.3 -0.5 -1.4 -1.1 -0.6 0.1 -0.0 0.4 0.1 0.2
Supplements: Fish oil (including cod liver oil) 0.6 0.8 4.4 -0.2 0.4 -2.1 -0.9 0.6 -1.1 0.7 0.8 0.8 -0.0 0.5
High cholesterol (Self-reported) 0.6 1.0 1.7 -1.3 -0.8 0.4 -0.7 -0.9 -0.4 -1.3 1.3 -1.0 -1.2 -1.3
Medication: Bendroflumethiazide 2.1 3.3 10.0 1.4 -2.2 -1.8 -2.7 -3.2 -1.4 1.1 -0.2 1.5 1.8 0.3
Medication: Paracetamol 0.6 0.9 3.3 1.1 -1.4 -1.8 -0.5 0.0 -1.1 0.6 -0.5 1.0 0.9 -0.1
Medication: Lisinopril 0.2 0.3 2.2 -0.3 -0.2 -0.5 0.4 -1.5 0.5 0.1 0.0 -0.0 0.4 -0.0
Medication: Atorvastatin 1.2 1.5 3.5 -1.3 -1.5 -0.5 -1.4 0.2 -1.2 -1.1 1.9 -0.5 -1.6 -1.0
Illnesses of father: High blood pressure 0.2 0.2 0.9 0.2 -0.1 -0.1 0.1 -0.9 0.5 0.5 -0.6 0.2 0.7 0.2
Alcohol drinker status: Never 0.4 0.5 1.6 1.1 -0.2 -0.1 -0.2 1.2 0.5 0.4 -1.2 0.4 0.8 0.2
Ever smoked 0.3 0.5 2.3 0.2 0.3 1.5 -0.7 0.8 -0.5 -0.3 1.1 0.2 0.4 0.1
Basal metabolic rate 0.3 1.8 4.5 1.5 0.5 -1.2 -2.1 -0.1 -0.1 1.5 -0.8 1.4 1.6 1.8
Leg fat percentage (left) 1.0 3.5 15.4 2.0 -1.3 -3.9 0.0 -0.4 -0.4 1.8 -1.0 2.2 2.3 1.6
Arm fat-free mass (left) 0.3 1.7 3.9 1.6 0.9 -1.0 -2.0 -0.3 0.1 1.6 -1.1 1.4 1.4 1.8
Number of operations (self-reported) 0.9 1.3 4.7 -0.7 2.2 0.7 -0.6 1.4 -1.4 -1.2 1.2 -0.9 -0.3 -0.6
Average weekly beer plus cider intake 1.1 1.6 4.1 -1.4 0.3 0.7 1.3 0.1 2.0 -0.8 -1.0 -1.7 -1.7 -1.2
Irritability 0.5 0.9 2.0 1.4 0.3 0.3 -1.1 -0.3 -0.4 1.3 -1.0 1.3 1.3 0.3
Risk taking 0.4 0.5 1.8 -0.6 1.4 -0.1 0.4 0.8 0.1 -1.1 0.0 -1.1 -0.5 -0.4
Ever had prostate specific antigen (PSA) test 0.6 0.7 3.8 0.2 1.9 0.4 0.5 0.7 1.1 0.3 -1.2 -0.1 -0.1 0.2
Fractured/broken bones in last 5 years 0.9 1.2 5.3 -1.0 -0.6 -0.1 -2.3 -0.7 -0.6 -1.2 1.4 -0.8 -1.0 -0.9
Age started oral contraceptive pill 0.4 0.5 2.0 -0.2 -0.3 -0.2 -1.4 -0.4 -1.4 -0.7 0.6 -0.2 -0.4 -0.9
Diastolic blood pressure, automated reading 1.4 4.4 21.6 -0.7 0.1 2.0 -0.4 -4.6 2.7 -0.3 -3.2 -1.8 -1.0 -1.0
Ever depressed for a whole week 0.6 0.7 2.0 0.7 -1.3 -1.3 0.1 -1.4 -1.0 0.2 -0.2 0.6 0.6 -0.5
Unable to work because of sickness or disability 0.4 0.6 2.0 0.6 -0.7 -0.3 0.2 0.0 1.3 1.0 -1.4 0.4 0.4 0.5
Commuting to job workplace: Cycle 1.3 1.5 4.5 -0.3 -0.3 0.6 -1.8 -1.6 -1.7 -1.4 0.1 -1.2 -0.2 -2.1
Myopia 1.5 2.2 4.8 -1.5 2.0 2.0 1.1 0.3 0.8 -2.2 0.3 -2.2 -1.4 -0.8
Vascular/heart problems diagnosed by doctor 0.7 2.0 8.8 -0.4 1.6 -0.1 1.7 3.0 1.8 -0.5 -1.0 -1.1 -1.2 -0.4
Cholesterol lowering medication 0.8 1.2 3.6 1.4 -0.0 -0.6 -1.9 -1.3 -1.5 0.8 0.1 1.2 1.2 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.1 1.1 0.7 -0.6 1.4 0.5 0.5 1.1 -1.2 1.1 1.7 1.8
Pain experienced in last month 0.4 0.7 2.2 -0.9 0.7 0.2 1.5 0.6 1.0 -1.0 0.5 -1.1 -0.8 -0.3
Supplements: Calcium 1.5 1.6 4.1 1.2 0.6 -2.0 -0.9 0.7 -1.8 1.2 -0.1 1.2 1.1 1.7
Basal cell carcinoma (self-reported) 0.6 0.7 2.0 -0.1 0.6 -0.6 0.4 1.1 -1.4 0.0 1.0 0.9 0.4 1.4
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.8 0.9 -1.7 -0.3 -0.8 0.7 -1.1 1.0 0.1 1.6 0.8 1.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 1.2 0.3 -0.1 1.1 -0.8 0.8 -0.9 0.4 0.3 0.4 0.5 0.1
Heart disease (siblings) 1.5 1.8 3.5 1.5 -1.7 -1.0 -1.3 -0.9 -1.4 1.5 -0.4 1.9 1.8 0.7
Alcohol drinker status: Previous 0.8 1.0 2.8 0.4 0.7 1.2 1.4 0.3 1.5 1.1 -1.7 0.3 0.2 0.4
Pack years of smoking 1.5 2.3 8.4 0.5 -2.2 -0.5 1.7 -0.4 2.4 1.4 -2.9 0.3 -0.3 -0.2
Impedance of whole body 0.3 1.5 6.4 -1.6 -0.4 0.0 1.2 1.3 -1.6 -1.1 2.5 -0.2 -0.9 0.3
Leg fat mass (left) 0.9 3.4 12.7 2.0 -1.1 -3.6 -0.5 -0.1 -0.3 2.0 -1.1 2.1 2.5 1.9
Arm predicted mass (left) 0.3 1.7 4.4 1.5 1.2 -0.9 -2.1 -0.2 0.2 1.4 -1.0 1.3 1.4 1.8