Hub : Genes

MKKS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1840	0.0340	1.1e-11	0.134	0.136	0.150	0.152	0.144	5.8e-16	3.1e-16	8.3e-18	4.3e-18	3.6e-17
2	GTEx	Adipose Subcutaneous	0.1350	0.0470	3.1e-03	0.000	NA	-0.003	NA	-0.003	3.1e-01	NA	9.6e-01	NA	9.5e-01
3	GTEx	Artery Aorta	0.1410	0.0560	7.9e-03	0.005	NA	0.059	NA	-0.002	1.6e-01	NA	3.6e-04	NA	4.1e-01
4	GTEx	Artery Tibial	0.1443	0.0529	2.6e-03	0.014	NA	0.030	NA	0.030	2.5e-02	NA	2.1e-03	NA	2.0e-03
5	GTEx	Skin Not Sun Exposed Suprapubic	0.2040	0.0670	4.6e-03	-0.005	NA	0.008	NA	-0.001	8.6e-01	NA	1.1e-01	NA	3.5e-01
6	GTEx	Whole Blood	0.1310	0.0410	2.3e-04	0.072	NA	0.032	NA	0.053	3.8e-07	NA	5.9e-04	NA	1.3e-05
7	ROSMAP	Brain Pre-frontal Cortex	0.1545	0.0368	1.3e-06	0.054	0.065	0.078	0.075	0.070	1.6e-07	9.5e-09	3.3e-10	7.2e-10	2.6e-09
8	TCGA	Colon Adenocarcinoma	0.0600	0.0390	8.1e-03	-0.002	0.028	0.024	NA	0.010	4.1e-01	9.4e-03	1.5e-02	NA	8.2e-02
9	TCGA	Brain Lower Grade Glioma	0.0314	0.0177	3.0e-03	0.019	0.022	0.023	NA	0.019	2.7e-03	1.3e-03	1.2e-03	NA	2.8e-03
10	TCGA	Prostate Adenocarcinoma	0.0368	0.0234	6.8e-03	0.033	0.001	0.014	NA	0.016	1.9e-04	2.3e-01	1.3e-02	NA	7.0e-03
11	TCGA	Thyroid Carcinoma	0.0410	0.0250	9.1e-03	0.014	0.006	0.005	NA	0.010	1.5e-02	7.7e-02	8.8e-02	NA	3.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.9	1.3	4.2	-1.7	-0.1	0.0	0.8	-0.4	0.2	-1.4	1.6	-1.2	-2.0	-0.9
Bipolar Disorder or Schizophrenia	0.3	0.8	2.4	0.5	-0.7	-1.0	1.6	-1.1	1.1	0.7	-1.0	0.4	0.4	0.4
Depressed Affect (Nagel 2018)	2.0	4.3	8.8	3.0	-2.3	-0.9	-1.9	-1.6	-1.6	2.4	-0.8	2.9	2.8	1.0
Depression (Nagel 2018)	3.7	5.6	15.8	4.0	-0.9	0.2	-0.1	-0.9	1.6	3.2	-3.7	2.8	2.8	1.5
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.3	-1.3	0.3	0.8	-0.6	-0.1	0.7	-1.5	1.4	-1.2	-1.4	-1.1
Neuroticism (Nagel 2018)	1.2	2.7	5.1	2.3	-1.9	1.0	-2.2	-2.2	-1.3	1.5	-0.3	2.0	1.6	-0.0
Schizophrenia (2018)	1.3	2.8	6.8	2.1	-1.1	-0.9	1.3	-1.3	1.2	2.0	-2.6	1.5	2.2	1.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	0.3	-1.0	0.0	-0.8	-0.8	0.5	0.1	-1.3	-0.5	-0.0	-1.0
Worry (Nagel 2018)	0.5	1.0	6.2	0.7	-0.8	1.3	-0.6	-2.5	-0.3	0.1	0.4	0.5	0.4	-0.7
Alzheimer’s Disease (in mother)	1.3	1.5	3.9	-1.0	-1.8	1.4	-0.3	2.0	-0.1	-0.6	-0.0	-1.0	-1.1	-2.0
Alzheimer’s Disease (in father)	0.4	0.4	1.5	-0.2	0.6	-0.1	-0.4	-1.2	-1.1	-0.6	0.5	-0.4	0.1	0.5
Alzheimer’s Disease (including proxy)	0.6	0.9	1.9	-1.0	-1.2	0.1	-1.1	0.9	-0.4	-1.0	0.1	-1.2	-1.0	-1.4
Crohns Disease (2017)	0.3	0.6	1.9	1.4	-0.4	0.9	0.5	-0.4	0.6	0.8	-0.9	1.0	0.7	0.3
Irritable Bowel Disease (IBD)	0.8	1.8	5.2	2.3	-0.2	-0.1	-0.2	0.6	1.4	1.6	-1.9	1.7	1.4	1.0
Ulcerative Colitis (UC)	0.8	1.5	4.3	1.6	0.2	-0.3	-0.2	0.8	2.0	1.5	-2.1	1.2	0.7	0.8
Major Depression (MDD)	0.9	1.1	3.3	1.8	-1.0	-1.1	-0.8	-0.0	-0.4	1.4	-1.0	1.4	0.7	0.5
Reaction Time	0.3	0.6	3.4	0.3	0.7	-0.7	0.2	0.7	1.2	0.6	-1.8	-0.4	0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.5	-1.1	1.4	1.4	-0.7	1.6	1.0	-1.1	1.0	-0.9	-0.9	0.1
Breast Cancer	0.3	0.7	2.5	0.5	-0.1	0.3	1.6	0.3	1.2	0.9	-0.9	0.8	0.7	0.7
Ovarian Cancer	0.3	0.3	1.6	-0.3	0.6	-0.3	0.0	-1.3	0.4	-0.0	-0.3	-0.4	0.9	-0.6
Prostate Cancer	0.5	0.7	2.7	0.9	0.7	-1.6	-0.4	-0.2	-1.0	0.5	-0.3	0.6	1.3	0.3
Age at First Birth	1.1	1.6	4.5	-0.3	-0.6	1.2	-1.6	-1.0	-2.1	-1.3	1.7	-0.7	-0.5	-1.3
Bipolar Disorder (2011)	1.6	1.5	4.0	1.8	0.0	-0.3	-0.6	-0.5	-0.4	2.0	-0.6	2.0	1.0	1.9
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-0.7	0.5	-0.0	-0.6	-0.2	-1.1	-1.0	1.2	-0.5	-0.5	-0.3
Coronary Artery Disease (CAD)	0.7	0.8	1.6	0.8	-0.5	-0.9	0.8	0.7	-1.2	0.9	0.7	1.2	0.5	1.3
Crohns Disease (2012)	0.3	0.4	1.4	0.8	-0.8	0.8	0.2	-0.0	0.8	0.4	-1.2	0.5	0.1	0.2
Mean Putamen Volume	0.9	1.1	2.8	-0.5	0.8	1.6	0.8	1.4	1.7	0.0	-0.9	-0.6	-1.3	-0.1
Fasting Glucose	1.0	1.2	2.8	0.8	-0.4	-1.7	1.5	-1.3	1.1	1.1	-1.5	0.5	0.7	0.1
HbA1C	1.3	1.4	8.0	0.2	-0.0	-1.1	-2.8	-1.4	-1.7	-0.2	0.8	0.3	0.7	0.1
HDL Cholesterol	0.2	0.4	1.1	-0.6	1.1	-0.7	1.0	-0.1	0.7	-0.3	-0.1	-0.3	-0.2	0.4
LDL Cholesterol	0.5	0.8	2.4	1.5	-0.3	-1.1	-0.3	0.2	-0.8	1.1	-1.0	1.1	0.7	0.2
Lupus	0.5	0.8	4.1	-0.2	0.9	-0.0	0.6	1.0	-0.1	0.7	1.2	0.7	0.4	2.0
Neuroticism (2016)	0.9	1.2	3.3	1.8	0.5	0.5	-1.5	-0.6	-0.5	1.5	-1.0	1.4	1.2	0.2
Primary Biliary Cirrhosis	0.5	0.7	1.7	-0.7	-1.0	0.9	-1.3	-1.2	0.5	-0.5	-0.2	-0.8	-1.1	-0.6
Rheumatoid Arthritis	0.7	1.0	3.7	-0.1	1.9	0.4	1.9	-0.2	0.1	0.4	0.1	0.5	-0.1	1.8
Schizophrenia (2014)	0.7	1.5	3.6	1.2	-1.7	-1.8	1.2	-0.8	1.0	1.2	-1.9	0.6	0.5	-0.0
Triglycerides	0.3	0.5	1.0	1.0	-0.8	-0.9	-0.8	-0.1	-0.8	0.7	-0.5	0.8	0.1	0.2
Type 2 Diabetes (T2D) (2012)	1.5	1.8	5.1	-1.8	-0.3	2.1	-0.1	1.2	0.3	-1.0	0.1	-1.7	-2.3	-1.3
Ulcerative Colitis	1.1	1.5	2.8	1.4	-1.4	-0.9	-0.1	1.4	1.4	1.3	-1.7	1.3	0.9	1.0
Blood Eosinophil Count	0.5	3.8	11.5	-0.7	-3.2	-1.8	-0.9	-2.5	-2.7	-0.0	3.4	1.2	0.1	0.1
Blood Platelet Count	0.0	0.5	2.5	-0.5	-0.1	0.6	0.3	1.6	0.1	0.5	1.0	0.6	-0.2	0.9
Blood Red Count	0.3	2.8	10.8	1.8	-0.8	-0.8	-1.8	-2.5	1.2	1.2	-3.3	0.2	1.1	-1.1
Blood White Count	0.5	3.5	17.5	0.4	-4.2	-2.1	0.6	-3.0	-1.2	1.1	1.1	1.8	0.4	-0.2
Heel T-Score	0.9	6.8	45.8	-1.0	-6.8	-3.3	-0.7	-0.4	-3.0	0.2	2.2	0.9	0.5	-1.1
BMI	0.8	4.7	11.1	3.3	0.2	-2.7	-1.3	-0.1	0.3	2.4	-1.8	2.6	3.1	2.4
Height	0.2	2.9	6.6	-0.5	2.2	0.5	-2.6	1.6	-2.5	-0.3	2.0	0.8	0.4	2.4
Waist Hip Ratio (WHR)	0.6	2.5	5.7	2.1	-0.8	-1.9	0.1	0.4	-0.1	2.1	-1.4	2.4	2.4	1.1
Systolic Blood Pressure	0.7	3.5	24.8	-0.2	-3.1	-0.5	-1.1	-5.0	-0.6	0.6	0.9	0.3	-0.2	-0.8
Smoking Status	0.5	1.3	2.8	1.1	0.3	-0.2	1.7	-1.5	0.7	1.2	-0.7	1.2	1.4	1.4
Allergy or Eczema	0.3	0.8	2.5	0.5	1.3	1.2	-0.3	0.5	-1.6	-0.4	0.5	0.2	1.0	0.9
Cardiovascular Disease	0.8	2.7	16.8	1.0	-1.8	-1.0	-1.1	-4.1	-0.6	1.3	-0.5	1.4	1.4	0.7
Hypothyroidism (self reported)	0.4	0.9	3.4	0.9	1.0	0.0	0.7	0.9	0.3	0.5	0.7	1.0	0.9	1.8
Respiratory disease	0.2	0.5	1.8	-0.2	-0.0	-1.3	-0.6	0.5	-1.0	-0.7	1.1	0.0	0.0	0.3
Type 2 Diabetes (T2D) (2018)	1.3	2.4	6.8	1.4	-1.6	-1.3	-1.7	-2.6	-0.8	1.9	-0.6	2.1	0.7	1.0
Lung FEV1/FVC ratio	0.2	0.8	2.6	-0.1	0.2	1.6	1.6	0.1	1.5	-0.5	-0.6	-0.7	-0.7	-0.3
Lung FVC	0.3	1.4	3.1	-0.1	1.0	0.8	-1.8	1.4	0.4	-1.2	-1.6	-1.5	0.1	-1.4
Neuroticism	1.2	2.9	6.4	2.5	0.3	1.0	-2.1	-1.7	-1.0	2.0	-0.3	2.5	1.9	1.3
Chronotype (morning person)	0.2	0.6	1.5	-1.2	-0.6	0.4	0.3	0.4	0.3	-0.7	0.4	-1.0	-0.9	-1.2
Hair Pigment	0.1	1.8	8.6	-1.9	0.1	-0.6	0.8	-0.8	-1.4	-1.5	2.9	-0.9	-0.9	0.3
Tanning	0.1	1.5	3.5	1.6	0.2	-1.3	1.2	0.5	0.2	1.9	-1.0	1.5	1.3	1.7
Hand grip strength (left)	0.2	0.6	2.1	-0.6	0.9	1.4	-0.4	1.0	0.3	-0.2	0.6	-0.2	-0.8	1.0
Number of treatments/medications taken	1.7	3.0	10.0	0.7	-1.4	-3.2	-1.4	-0.8	-3.0	0.7	1.2	1.7	1.6	1.3
Average weekly spirits intake	1.8	2.2	7.6	1.5	0.0	-0.8	-0.4	0.2	-2.8	0.9	2.1	1.8	1.8	1.5
Sensitivity / hurt feelings	0.7	1.2	4.6	-0.7	0.3	1.8	-1.5	-0.7	-0.9	-0.7	2.1	-0.0	-1.0	-0.2
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.9	1.6	-0.6	1.0	-0.7	-1.5	1.5	1.3	-2.0	0.9	0.7	0.4
Hearing difficulty/problems: Yes	0.9	1.3	4.6	0.4	0.3	0.9	-0.8	-1.1	0.8	-0.8	-1.9	-1.3	-0.5	-2.1
Relative age of first facial hair	1.0	2.1	5.3	-2.3	0.8	1.7	0.2	0.2	1.4	-1.4	1.0	-1.9	-2.2	-1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.5	0.8	0.0	-1.0	-1.0	0.7	-0.5	0.9	-0.1	1.2	1.0	1.2
Ever used hormone-replacement therapy (HRT)	2.5	3.2	8.0	1.9	0.1	-2.8	-2.1	-0.4	-2.8	0.7	1.0	1.9	2.3	0.9
Ever had hysterectomy (womb removed)	0.5	0.6	4.9	-0.4	2.2	0.4	-0.5	-0.1	-0.8	-0.5	0.4	-0.3	-0.3	0.3
Systolic blood pressure, automated reading	1.8	5.2	24.0	-0.7	-2.9	-0.3	-2.6	-4.9	-1.8	-1.2	2.0	-0.9	-1.2	-2.6
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.0	1.5	-0.6	-1.0	-0.7	-2.0	-1.6	1.2	0.3	1.6	1.4	0.7
Angina	0.7	1.0	2.8	0.6	-0.9	-1.0	0.9	0.2	-0.1	1.3	-0.3	1.7	0.8	1.6
Medication for hormone replacement therapy	2.0	2.2	4.6	2.1	1.1	-1.6	-1.1	1.2	0.0	1.3	-1.5	1.3	2.1	1.8
Vitamin and mineral supplements	0.6	0.9	1.9	1.4	-1.0	-1.0	0.4	-0.8	0.8	1.0	-0.9	1.2	0.9	0.6
Supplements: Zinc	2.7	3.0	6.9	2.6	0.1	-0.8	-0.3	0.7	-1.6	2.2	-0.9	2.6	2.3	2.0
Medication: Co-codamol	1.6	1.8	8.1	0.5	0.4	0.3	1.4	2.9	1.7	0.6	-2.3	-0.1	0.7	0.6
Medication: Metformin	0.4	0.6	1.5	0.4	-0.9	-0.7	-0.4	-1.2	-1.2	1.0	-0.0	1.0	0.3	0.4
Diabetes (father)	1.6	2.0	7.6	0.4	0.3	-0.6	2.8	-1.2	2.7	1.0	-1.9	-0.1	-0.1	0.5
Diabetes (mother)	0.5	0.7	1.4	0.8	-1.1	-1.1	0.4	-0.7	-0.1	1.2	-0.5	0.9	1.1	0.5
Severe depression (siblings)	0.8	0.9	3.5	0.8	-0.9	-0.6	-0.2	0.4	1.1	1.3	-1.9	0.7	0.5	0.6
Pack years adult smoking proportion	1.6	2.5	8.1	0.5	-2.5	-0.3	1.8	-1.0	2.4	1.4	-2.9	0.3	-0.2	-0.4
Impedance of leg (right)	0.3	1.3	6.1	-1.5	-0.4	0.1	2.5	1.3	0.1	-0.8	1.1	-0.4	-1.4	0.3
Leg fat-free mass (left)	0.4	1.9	5.6	1.6	0.1	-1.3	-2.4	-0.2	-0.3	1.4	-0.5	1.4	1.7	1.8
Trunk fat percentage	1.3	5.0	17.6	2.1	-1.7	-4.2	-0.9	0.6	-2.1	1.9	0.4	2.7	3.1	2.1
Hand grip strength (right)	0.3	0.9	5.5	0.4	-0.1	0.9	-2.3	0.8	-1.4	0.0	0.8	0.5	0.5	0.4
Townsend deprivation index at recruitment	0.7	1.0	4.3	-0.2	-0.3	1.3	-0.2	0.6	2.1	-0.3	-1.2	-1.2	-0.8	-0.7
Current tobacco smoking	0.8	1.3	5.9	0.6	-0.3	-0.2	2.4	-1.0	1.7	0.9	-1.3	0.6	0.5	0.8
Average weekly fortified wine intake	1.7	2.0	4.9	1.8	2.2	-0.9	-0.9	1.5	-0.1	0.9	0.1	1.7	1.4	2.2
Maternal smoking around birth	1.4	2.0	9.7	0.5	2.1	1.2	3.1	1.2	1.1	0.7	-0.2	0.4	0.1	1.8
Fed-up feelings	0.6	1.1	5.4	1.2	-1.4	0.0	-1.6	-2.3	-0.4	0.4	-0.2	0.7	0.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	7.6	2.8	-0.1	1.0	-0.8	-0.5	2.1	2.2	-2.7	1.8	1.7	1.1
Relative age voice broke	1.0	1.5	4.2	-1.8	-0.0	0.6	-0.6	-0.1	0.8	-1.6	0.4	-2.0	-1.7	-1.4
Taking other prescription medications	0.6	0.9	2.6	-0.2	-1.5	-1.6	-0.8	-1.1	-1.6	-0.3	1.0	0.1	0.2	0.1
Age when periods started (menarche)	0.7	1.7	6.2	-1.4	0.1	2.5	0.9	0.9	1.2	-0.9	-0.1	-1.5	-2.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	5.7	0.2	2.4	0.8	-0.6	1.0	0.0	0.1	0.4	0.1	0.3	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	17.0	1.0	-4.1	-1.6	-1.3	-0.4	-1.7	0.8	-0.2	1.3	1.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.7	0.5	1.6	0.2	0.2	-0.0	0.7	1.3	-0.5	0.9	0.9	1.9
Qualifications: CSEs or equivalent	0.3	0.4	2.4	-0.9	-0.2	1.6	-0.1	0.1	0.1	-0.2	0.1	-0.5	-0.9	-0.1
Serious illness, injury or assault to yourself	0.4	0.4	1.7	0.6	0.3	-1.3	-0.4	0.0	-0.9	-0.3	0.8	0.3	0.8	0.5
High blood pressure	1.0	2.7	14.7	0.5	-1.9	-0.2	-2.3	-3.8	-1.8	0.5	0.7	0.9	1.2	-0.2
Hayfever, allergic rhinitis or eczema	0.5	1.2	3.8	0.5	1.9	1.1	0.3	1.3	-1.2	-0.1	0.7	0.5	0.8	1.7
Multivitamins +/- minerals	0.9	1.1	3.3	-1.3	-0.4	1.0	-1.8	-0.3	-1.0	-1.1	1.0	-1.0	-0.7	-1.1
Stomach or abdominal pain in last month	1.2	1.6	5.2	1.3	1.2	-0.1	1.0	0.3	-0.4	1.7	-0.5	1.7	1.3	2.3
Supplements: Glucosamine	0.8	1.0	4.4	-0.7	2.1	0.4	-1.3	1.2	-0.4	-1.2	0.3	-1.2	-0.2	-0.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	5.7	1.0	-0.9	-1.8	0.2	-2.4	-0.5	0.6	0.3	1.2	1.3	0.3
Medication: Atenolol	0.3	0.4	1.8	-0.2	-1.3	-0.1	0.7	-1.0	0.3	0.2	0.5	0.4	-0.5	0.3
Medication: Levothyroxine sodium	0.8	1.3	3.5	1.0	0.9	-1.1	-1.2	0.6	-1.3	0.4	1.3	1.2	0.8	1.9
Sitting height	0.3	1.9	5.3	-1.2	1.9	1.4	-2.3	1.1	-0.7	-0.9	2.0	-0.4	-0.7	1.3
Chronic bronchitis/emphysema (father)	0.6	0.7	3.2	0.5	-1.3	-0.6	0.3	-1.8	0.2	1.2	-0.4	0.9	0.1	-0.0
High blood pressure (mother)	1.4	1.9	6.2	1.2	-1.2	-0.6	-1.5	-2.5	-1.4	1.0	1.0	1.8	0.8	1.3
Body mass index (BMI)	0.9	3.9	9.1	2.7	-0.8	-3.0	-0.8	-0.6	0.2	2.4	-1.9	2.2	2.8	1.5
Impedance of leg (left)	0.3	1.6	7.3	-1.9	-0.2	0.2	2.7	0.8	-0.2	-1.2	1.4	-0.7	-1.4	0.1
Leg predicted mass (left)	0.4	2.0	6.0	1.6	-0.0	-1.3	-2.4	-0.3	-0.3	1.5	-0.6	1.5	1.8	1.7
Trunk fat mass	1.1	4.6	15.0	2.1	-1.2	-3.9	-1.0	0.6	-1.5	2.0	-0.0	2.6	3.0	2.4
Waist circumference	1.2	4.6	10.6	2.6	-1.1	-3.3	-1.1	-0.2	0.0	2.8	-1.6	2.8	2.8	2.2
Number of incorrect matches in round	0.7	1.2	5.6	-0.1	1.5	0.6	0.9	2.4	0.0	1.0	0.5	0.8	0.0	1.7
Past tobacco smoking	0.6	1.1	5.0	-0.0	0.2	-0.4	1.2	-0.2	2.0	0.6	-2.2	-0.6	-0.8	-0.2
Alcohol usually taken with meals	0.3	0.5	3.0	-0.4	0.5	-0.2	-1.0	0.1	-0.8	-0.8	1.7	-0.3	-0.1	-0.2
Nervous feelings	0.7	1.3	11.8	0.4	-0.6	0.6	-0.6	-3.4	-0.2	0.2	0.3	0.2	0.1	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	5.8	1.4	0.8	1.5	-0.7	-0.0	2.0	1.2	-2.4	0.4	0.6	0.7
Hearing difficulty/problems with background noise	0.2	0.4	1.1	0.9	0.1	-0.2	-0.9	-0.4	-0.3	0.1	-1.0	0.2	0.5	-0.8
Hair/balding pattern: Pattern 2	0.7	0.9	2.7	0.8	0.7	0.4	0.7	1.2	1.5	0.9	-1.6	0.3	-0.3	0.5
Had menopause	1.0	1.3	5.6	0.3	1.5	-1.5	-2.4	-0.0	-1.3	0.3	0.6	0.7	0.3	1.2
Had other major operations	0.3	0.4	2.2	0.1	1.5	0.7	0.9	0.0	-0.2	0.1	-0.6	-0.2	0.1	0.1
Forced vital capacity (FVC)	0.3	1.3	4.7	-1.2	1.6	2.2	-0.8	1.2	0.2	-1.3	0.3	-1.3	-0.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	22.6	0.4	-4.8	-1.0	-0.7	-0.4	-1.6	0.6	0.0	1.1	0.5	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.6	0.7	-1.3	-0.6	0.8	-1.2	0.1	0.5	-1.1	0.5	0.6	-0.6
Qualifications: None of the above	0.6	1.2	3.2	1.3	-1.4	0.1	1.6	-0.0	0.1	1.2	-1.8	0.9	1.2	0.4
Financial difficulties in last 2 years	0.5	0.7	3.6	0.6	-0.8	1.1	0.1	-0.4	1.9	0.0	-1.3	-0.4	-0.0	-0.5
Mouth/teeth dental problems	0.5	0.8	2.3	-0.9	1.5	-0.0	0.9	0.8	1.5	-0.3	0.4	-0.7	-1.3	0.0
Heart attack	0.9	1.1	2.7	1.1	-1.6	-0.2	-1.0	0.5	-1.0	1.1	-0.1	1.6	0.8	1.1
Allergy	0.5	1.2	3.8	-0.8	-1.8	0.0	0.3	-2.0	0.9	-0.4	-0.1	-0.6	-0.9	-1.7
Pain all over the body in last month	2.6	2.7	5.5	1.0	-0.0	0.1	1.4	1.9	2.3	2.3	-2.4	1.4	1.3	2.0
Diabetes (self-reported)	1.7	2.7	4.7	1.4	-2.0	-1.3	-2.0	-2.2	-2.0	1.6	0.3	2.1	1.1	0.8
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	4.2	-1.5	0.6	1.7	-1.0	1.4	-1.4	-2.1	1.6	-1.7	-1.1	-1.5
Medication: Ramipril	1.1	1.4	3.2	-1.7	-1.8	0.9	0.8	-0.8	0.1	-1.1	1.4	-1.0	-1.2	-1.2
Medication: Simvastatin	0.4	0.6	1.3	0.8	-0.4	-1.1	-0.0	-0.4	-1.0	0.8	0.1	1.1	0.8	0.5
Fluid intelligence score	1.7	3.5	6.9	-2.3	1.3	2.6	-0.4	2.0	1.7	-2.1	1.1	-2.2	-2.6	-0.5
Illnesses of siblings	0.8	1.2	5.0	0.7	1.4	0.5	0.7	1.3	2.2	0.7	-1.7	0.0	0.1	0.4
Neuroticism score	0.9	1.9	6.3	1.8	-0.5	0.8	-1.9	-2.5	-0.3	1.5	-0.5	1.7	1.3	0.2
Weight	0.6	3.0	6.3	2.0	-0.0	-2.5	-1.8	0.0	-0.7	2.0	-0.6	2.1	2.3	2.2
Impedance of arm (right)	0.3	1.4	4.9	-0.9	-0.0	-0.3	1.2	2.0	-1.8	-0.5	2.2	0.4	-0.2	0.8
Arm fat percentage (right)	1.3	5.2	16.9	2.8	-1.3	-4.1	-0.3	0.5	-0.8	2.5	-0.9	2.8	3.4	1.9
Trunk fat-free mass	0.2	1.1	3.4	0.9	1.5	-0.1	-1.9	0.0	0.6	1.1	-0.8	0.7	0.7	1.5
Hip circumference	0.5	2.1	6.0	1.5	-0.4	-2.5	-1.1	-0.4	0.1	1.7	-0.8	1.6	1.7	2.1
Time employed in main current job	0.7	0.8	4.0	-0.4	-0.3	1.1	1.7	-2.0	0.1	0.2	0.2	0.0	-0.8	-0.1
Alcohol intake versus 10 years previously	0.6	1.0	2.7	1.1	-1.4	-1.6	-0.1	-0.9	-0.9	1.0	-0.2	1.1	0.8	0.2
Father’s age at death	2.3	3.1	7.3	-2.2	2.7	1.6	-0.7	1.6	0.6	-2.0	1.1	-2.1	-2.4	-0.2
Worrier / anxious feelings	0.5	0.9	5.1	-0.0	-0.1	1.7	-0.2	-2.2	-0.4	-0.3	1.0	0.1	-0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.6	1.4	0.5	1.1	0.2	0.0	1.3	1.3	-1.6	1.3	1.3	1.5
Falls in the last year	0.2	0.3	1.3	0.1	1.1	-0.5	-0.4	0.3	-0.4	0.4	0.4	0.1	-0.1	1.0
Hair/balding pattern: Pattern 3	1.0	1.4	3.6	-1.3	1.2	1.4	0.3	1.9	-1.2	-1.0	1.9	-0.5	-0.5	0.8
Number of live births	0.6	0.8	2.2	-0.1	1.3	-0.0	0.7	-1.3	1.5	-0.5	-1.3	-0.9	-0.0	0.0
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	7.7	-1.4	1.3	2.8	-0.2	1.0	0.8	-1.5	-0.0	-1.7	-1.3	-0.8
Pulse rate	0.1	0.2	0.4	0.6	0.0	-0.3	0.4	-0.7	0.5	0.6	-0.3	0.3	0.2	-0.1
Happiness	0.7	0.8	2.5	-0.8	-0.5	1.1	1.5	0.2	1.6	-0.4	-0.0	-0.7	-1.0	-0.7
Noisy workplace	0.2	0.3	0.7	-0.6	-0.2	-0.2	0.4	0.3	0.7	-0.8	-0.1	-0.8	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.3	-1.6	0.0	-0.2	-2.1	-0.1	-0.7	-1.8	2.0	-1.4	-1.3	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.1	-0.3	-0.2	0.4	-0.9	0.7	0.2	-0.9	-0.2	-1.1	-0.6	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	2.8	-0.2	-0.8	-0.2	-0.8	-0.7	-1.7	0.0	0.7	0.6	0.3	0.3
Asthma	0.4	0.7	4.3	0.0	-0.0	-2.1	-1.4	-0.5	-0.8	-0.5	0.8	0.0	-0.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.8	-0.5	-0.8	-0.3	1.3	-1.0	-1.9	-0.3	1.8	0.5	-0.1	0.4
Medication: Cholesterol lowering	0.7	1.2	4.6	-0.5	-2.1	-1.6	-0.7	-0.1	-1.5	-0.2	1.5	0.4	-0.3	-0.3
Depression (self-reported)	1.2	1.4	3.4	1.7	-0.3	-1.8	-0.9	-0.4	-1.1	1.4	-0.2	1.7	1.0	1.2
Medication: Lansoprazole	0.2	0.2	1.0	0.0	0.3	-0.3	-0.1	-1.0	-0.1	0.1	0.2	0.3	0.7	0.5
Prospective memory result	0.6	0.7	2.2	0.5	-0.5	-1.5	1.5	-0.3	-0.1	1.1	-1.1	0.5	0.9	0.1
Lung cancer (father)	1.0	1.2	2.9	-1.6	-0.2	1.1	1.7	-0.2	0.9	-1.1	-0.2	-1.4	-1.4	-0.7
Illnesses of mother	1.7	2.0	3.9	-1.6	0.7	1.8	1.1	2.0	0.6	-1.6	0.4	-1.9	-1.5	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	6.3	-0.8	1.6	2.5	-0.5	1.2	0.9	-1.1	-0.8	-1.5	-0.8	-0.4
Pulse wave Arterial Stiffness index	1.0	1.2	2.9	0.5	1.6	0.4	0.5	1.7	1.3	0.9	-1.1	0.5	0.4	1.6
Impedance of arm (left)	0.4	1.9	8.7	-1.0	-0.7	-0.7	0.3	1.4	-2.6	-0.7	2.9	0.4	-0.1	0.5
Arm fat mass (right)	1.1	4.5	12.1	2.6	-0.7	-3.5	-0.9	0.3	-0.5	2.5	-1.0	2.6	3.1	2.2
Trunk predicted mass	0.2	1.0	3.1	0.9	1.5	-0.1	-1.8	-0.0	0.7	1.0	-0.9	0.6	0.6	1.5
Standing height	0.3	2.6	6.6	-1.5	2.0	1.2	-2.2	1.5	-1.6	-0.9	2.6	-0.3	-1.1	1.7
Length of working week for main job	0.9	1.0	3.6	0.6	0.7	-0.3	0.4	1.9	1.0	0.9	-1.3	0.6	0.9	1.3
Exposure to tobacco smoke at home	0.9	1.0	5.1	-0.1	-2.3	0.5	-1.2	-0.1	0.5	0.1	-1.3	-0.7	-0.1	-1.2
Breastfed as a baby	1.7	2.1	4.7	-1.9	0.6	-0.0	-1.6	1.1	-0.7	-2.1	2.2	-1.7	-1.5	-1.3
Tense / ‘highly strung’	1.8	3.0	9.8	0.7	-2.0	2.0	-3.1	-2.8	-1.8	-0.0	0.8	0.4	0.3	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.3	3.4	1.8	0.0	-1.0	-0.3	-0.5	-1.5	0.7	0.0	1.5	1.6	1.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	0.5	-0.4	0.0	-0.8	-0.7	0.2	0.2	-0.9	0.3	0.9	-0.2
Birth weight of first child	0.3	0.6	1.2	-0.9	1.0	0.8	0.8	-0.4	-0.0	-0.5	-0.3	-1.0	-1.1	-1.0
Peak expiratory flow (PEF)	0.3	0.6	1.4	-0.9	1.2	0.9	-0.6	0.9	-0.0	-1.0	0.6	-1.1	-0.6	-0.1
Pulse wave reflection index	2.2	2.7	12.6	0.2	1.6	0.6	1.6	-0.0	3.5	1.1	-3.0	-0.4	-0.3	0.8
Ever highly irritable/argumentative for 2 days	4.3	5.2	12.2	2.5	-1.0	-1.6	2.8	1.3	1.6	3.1	-3.5	2.4	2.1	1.9
Loud music exposure frequency	1.0	1.0	5.0	0.1	1.0	0.2	2.2	0.1	1.5	0.3	-1.5	0.0	0.2	0.8
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	4.7	-1.9	0.5	1.9	-1.4	0.2	0.2	-2.0	1.3	-2.1	-2.2	-1.9
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	8.9	1.5	-3.0	-0.5	-0.8	-1.4	-0.4	1.0	-1.3	1.0	1.5	-0.4
Blood clot in the leg (DVT)	0.3	0.4	1.0	0.5	0.3	0.9	-0.9	0.8	-1.0	0.4	0.4	0.4	0.3	0.3
Medication: Paracetamol	1.0	1.7	3.7	1.8	-1.3	-1.9	-0.2	-0.2	-1.4	1.3	-0.8	1.7	1.6	0.2
Headache pain in last month	0.7	1.2	2.8	1.7	0.2	0.9	-0.5	-1.1	-1.1	1.3	-0.7	1.4	1.2	1.0
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	5.7	0.4	2.4	0.8	0.7	1.4	0.9	-0.1	-1.1	-0.4	-0.3	0.2
Glaucoma (self-reported)	0.2	0.3	1.3	-0.8	0.3	0.1	0.9	-0.0	0.1	0.1	0.3	0.1	-0.1	1.1
Gout (self-reported)	0.4	0.5	2.9	0.0	0.6	0.5	0.1	0.2	0.1	0.6	0.5	0.8	0.7	1.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.9	0.6	0.8	-0.2	-0.4	0.7	-0.3	0.2	0.9	0.7	0.6	1.4
Medication: Amlodipine	3.5	4.9	12.1	1.7	-3.3	-2.5	-2.0	-3.5	-2.6	1.4	0.1	1.9	2.2	-0.2
Medication: Ventolin 100micrograms inhaler	1.8	2.4	5.5	-1.3	-1.7	-1.3	-0.5	-0.9	-1.8	-2.1	2.3	-1.0	-0.9	-1.9
Birth weight	0.4	0.8	5.7	0.4	2.4	0.4	-1.0	-0.0	0.3	0.4	-0.6	-0.1	0.5	1.2
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.9	0.4	0.8	-1.3	1.3	1.7	-0.4	0.4	0.0	0.5	0.4	1.1
High blood pressure (siblings)	1.2	1.7	6.7	-1.5	-1.1	0.5	0.0	-2.6	-0.8	-1.1	1.9	-0.7	-1.2	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	4.6	-0.7	1.7	2.1	-1.4	1.1	0.1	-1.1	-0.2	-1.2	-0.4	0.0
Body fat percentage	1.2	4.6	17.6	2.1	-1.7	-4.2	-0.4	0.4	-1.5	2.0	-0.1	2.6	3.0	2.0
Leg fat percentage (right)	1.1	3.9	16.1	2.2	-1.5	-4.0	0.2	0.1	-0.3	2.1	-1.1	2.4	2.3	1.9
Arm fat-free mass (right)	0.2	1.2	5.7	1.0	0.5	-0.6	-2.4	-0.6	0.4	1.1	-0.8	0.8	0.8	1.3
Exposure to tobacco smoke outside home	1.5	2.0	4.3	1.8	1.4	0.3	0.8	-0.9	1.3	2.1	-1.9	1.3	1.4	1.6
Comparative body size at age 10	1.6	4.3	11.2	2.5	1.4	-2.2	1.7	0.3	1.8	2.7	-3.3	1.5	2.5	1.2
Number of full brothers	0.8	1.0	2.6	1.2	-0.9	-1.0	-0.6	-1.6	-1.2	0.8	-0.0	1.2	0.8	0.9
Worry too long after embarrassment	1.1	1.9	12.4	0.5	-0.3	3.5	-1.6	-1.9	-0.6	-0.0	0.4	0.3	-0.2	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.9	2.0	0.5	-0.2	-0.2	0.3	0.7	1.5	-1.3	1.5	1.1	1.6
Wheeze or whistling in the chest in last year	1.5	2.6	8.5	1.7	0.2	-2.9	-0.2	-0.3	-1.1	2.0	-0.2	2.3	1.8	1.8
Number of children fathered	0.6	0.7	1.8	-0.7	0.1	0.3	-1.3	0.7	-1.3	-0.7	0.5	-0.8	-0.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	2.1	-0.4	0.9	0.5	-0.7	-1.5	0.9	-0.0	-0.1	-0.3	0.0	-0.1
Age at first live birth	0.9	1.7	4.0	-1.5	-0.3	1.1	-1.5	-0.5	-0.6	-1.6	1.4	-1.5	-1.2	-2.0
Pulse wave peak to peak time	0.7	0.9	1.8	-0.5	-1.3	-0.3	-0.5	-1.3	-1.3	-0.8	1.2	-0.3	-0.3	-1.1
Health satisfaction	0.5	0.6	1.5	0.0	-1.1	-1.2	1.2	-0.2	1.1	0.6	-1.0	0.1	0.2	-0.1
Shortness of breath walking on level ground	2.3	2.8	8.5	1.3	0.0	-2.1	1.9	0.5	-0.2	1.9	-0.3	2.2	1.7	2.9
Qualifications: College or University degree	0.3	1.0	2.8	-1.4	1.5	0.6	-1.0	0.2	0.9	-0.5	1.7	-0.7	-0.9	0.3
Eye problems/disorders: None of the above	1.5	1.7	6.1	-0.5	1.2	2.1	2.5	0.8	2.1	-0.2	-1.1	-0.7	-0.4	0.2
Mouth/teeth dental problems: Loose teeth	0.9	1.0	5.2	-0.1	-2.3	-0.6	-0.5	0.4	0.1	-0.7	-0.9	-0.8	-0.1	-1.9
Emphysema/chronic bronchitis	0.7	0.8	1.4	0.8	0.7	-1.0	0.7	0.1	1.1	0.9	-1.1	0.7	1.1	1.2
Medication for pain relief, constipation, heartburn	0.8	1.4	3.5	-0.9	1.1	1.7	0.1	0.9	1.9	-0.9	-0.7	-1.7	-1.2	-0.8
Neck or shoulder pain in last month	1.2	1.7	4.5	1.7	-0.4	-1.0	-0.3	0.6	-0.7	2.1	-1.3	1.8	1.8	1.2
Medication: Blood pressure	0.6	1.1	5.1	-0.5	-2.3	-0.6	-0.7	-1.9	-0.9	0.3	1.1	0.4	0.3	-0.1
Angina (self-reported)	0.5	0.7	2.0	0.4	-1.0	-0.9	0.9	0.2	-0.0	1.0	-0.3	1.4	0.7	1.2
Migraine (self-reported)	1.8	2.2	6.6	-0.2	-2.5	1.0	-1.0	-1.8	1.1	-1.1	-1.2	-1.4	-0.8	-2.6
Medication: Ibuprofen	0.6	0.7	2.0	-0.3	-0.4	0.3	1.2	-0.8	-1.4	0.1	1.3	0.7	-0.1	0.9
Medication: Allopurinol	0.3	0.3	1.1	-0.2	0.3	0.8	0.6	-0.2	0.9	0.5	-0.3	0.4	0.3	1.1
Medication: Omeprazole	0.5	0.7	2.2	0.8	0.4	-0.1	0.7	0.5	0.5	0.8	-0.7	0.8	1.2	1.5
Medication: Seretide 50 evohaler	1.4	1.6	3.6	1.1	-0.6	-1.2	0.5	-1.4	-1.5	0.7	1.4	1.9	1.5	1.2
Mean time to correctly identify matches	0.3	0.6	1.3	-0.6	1.1	0.3	0.2	1.1	1.1	0.2	-1.0	-0.8	-0.7	0.2
Heart disease (mother)	2.8	3.4	8.6	2.3	-0.1	-1.7	-0.4	-1.3	-1.5	2.2	0.7	2.9	2.7	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	5.9	0.6	1.5	-0.0	2.4	1.3	0.8	0.9	0.5	1.1	0.6	1.8
Whole body fat mass	1.1	4.5	14.5	2.2	-1.0	-3.8	-0.8	0.5	-1.3	2.2	-0.3	2.7	3.0	2.4
Leg fat mass (right)	0.9	3.6	12.7	2.1	-1.3	-3.6	-0.3	0.1	-0.2	2.1	-1.2	2.2	2.5	1.9
Arm predicted mass (right)	0.3	1.3	6.5	1.2	0.5	-0.6	-2.5	-0.7	0.2	1.1	-0.8	1.0	1.0	1.3
Pulse rate, automated reading	0.1	0.2	0.6	0.2	0.4	0.7	-0.1	-0.5	0.1	-0.5	0.1	-0.4	0.2	-0.8
Alcohol intake frequency.	0.6	1.4	4.2	1.5	-1.6	-0.9	-0.0	-1.6	0.7	1.3	-2.1	0.8	0.6	0.1
Comparative height size at age 10	0.5	3.0	11.8	0.7	2.3	-0.3	-1.4	2.6	-0.8	1.1	0.8	1.7	1.0	3.4
Number of full sisters	0.8	1.0	3.5	0.9	-1.4	0.8	0.8	0.1	1.0	1.3	-1.9	0.9	0.7	0.3
Suffer from ‘nerves’	0.4	0.6	2.4	0.8	1.0	0.5	-0.8	-1.6	0.9	0.2	-0.7	0.2	0.2	0.1
Overall health rating	0.4	0.9	2.4	0.7	-0.3	0.1	1.3	-1.5	1.3	0.4	-1.5	0.2	0.4	0.7
Chest pain or discomfort	0.8	1.2	3.1	1.0	-0.3	1.1	0.2	0.0	0.4	1.4	-0.3	1.6	1.6	1.8
Had major operations	1.6	1.9	4.2	-1.9	0.4	1.1	-0.2	0.9	0.2	-1.9	1.2	-2.0	-1.8	-1.6
Age at last live birth	0.4	0.6	2.0	-0.9	0.0	0.5	-0.4	-0.8	0.5	-1.0	0.6	-1.1	-0.7	-1.4
Family relationship satisfaction	0.7	0.8	1.9	-1.0	-1.1	0.8	-0.3	-0.4	0.1	-0.9	0.8	-1.2	-1.1	-1.4
Leg pain on walking	0.6	0.7	3.9	0.1	-2.0	0.4	1.4	0.2	-1.0	-0.2	0.7	0.3	0.3	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	0.8	-1.0	-1.1	-0.5	-0.5	-0.7	-0.2	-0.5	0.1	0.4	-0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.1	-0.7	0.5	0.3	1.8	1.6	0.5	-0.3	0.8	-0.1	-0.6	0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.8	-0.3	0.7	-0.3	0.9	-1.3	-0.6	0.5	0.6	0.5	0.0	0.6
Medication: Aspirin	0.4	0.6	2.9	-0.5	-0.1	-0.7	-1.7	-0.1	-0.9	-0.5	1.1	0.1	-0.1	0.4
Supplements: Vitamin C	0.6	0.8	2.5	-0.6	1.5	-0.5	0.4	1.6	-0.9	-0.7	0.5	-0.7	-0.4	0.6
Knee pain experienced in last month	0.3	0.5	1.6	-0.4	-1.3	0.5	0.1	-0.4	0.5	-0.1	-1.0	-0.5	-0.6	-1.1
Hypertension (Self-reported)	0.8	2.3	14.3	0.5	-1.7	-0.2	-1.8	-3.8	-1.5	0.4	0.7	0.8	1.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	1.0	0.5	0.5	-0.7	-0.9	0.1	1.0	-0.6	0.9	0.7	1.3
Illnesses of father: Heart disease	0.5	0.8	1.8	1.2	0.5	-0.6	0.1	-0.7	-0.2	1.3	-0.1	1.3	1.2	1.0
Illnesses of siblings: Diabetes	0.7	0.9	3.9	0.2	-1.0	-0.9	-0.8	-0.4	-2.0	-0.5	1.4	0.4	0.6	-0.4
Smoking status: Previous	1.1	1.7	7.8	-0.8	-0.1	0.4	-1.5	-0.2	-2.7	-0.9	2.8	0.2	0.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	5.3	-0.2	1.6	2.0	0.6	1.9	1.3	0.8	0.1	0.6	0.2	2.3
Whole body fat-free mass	0.2	1.4	5.0	1.2	0.9	-0.7	-2.2	-0.1	0.2	1.3	-0.8	1.0	1.1	1.6
Leg fat-free mass (right)	0.3	1.5	5.7	1.3	0.3	-1.0	-2.4	-0.4	-0.4	1.2	-0.3	1.2	1.6	1.5
Arm fat percentage (left)	1.2	4.9	17.3	2.6	-1.5	-4.2	-0.6	0.3	-1.0	2.3	-0.5	2.7	3.3	1.7
Average weekly red wine intake	1.2	1.7	10.2	0.5	2.2	0.6	-3.2	-0.0	-0.7	-1.1	1.1	-0.2	0.3	-0.1
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.0	1.4	0.2	0.3	0.7	0.3	1.2	1.3	-1.2	1.1	0.8	0.6
Mood swings	1.3	2.4	5.7	2.4	-0.5	-0.1	-0.0	-2.1	-0.8	2.1	-1.5	2.0	1.9	0.5
Loneliness, isolation	0.8	1.1	6.4	0.9	-1.2	1.1	-2.5	-0.8	-0.9	-0.0	-0.1	0.5	0.3	-0.3
Long-standing illness, disability or infirmity	2.2	3.4	7.3	2.7	-0.8	-2.3	-2.0	-1.3	-0.8	2.3	-1.6	2.1	2.1	1.2
Ever had bowel cancer screening	0.4	0.5	2.2	-0.2	1.5	-0.5	0.4	0.9	-0.5	0.5	0.5	0.3	0.1	1.1
Diabetes diagnosed by doctor	0.9	1.5	5.8	0.4	-1.7	-0.6	-1.2	-2.4	-1.4	1.0	0.5	1.4	0.1	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.7	-0.8	0.5	0.9	-1.1	-1.2	0.5	-1.5	-0.1	-1.7	-1.1	-1.9
Friendships satisfaction	0.4	0.5	1.6	0.1	-1.3	-0.8	-0.6	-0.1	-1.3	-0.1	0.8	-0.0	-0.0	-0.7
Qualifications: nursing, teaching	0.3	0.5	2.0	0.6	1.4	-0.6	-1.2	-0.2	-0.6	-0.3	-0.1	0.2	0.8	-0.4
Commuting to job workplace: Walk	0.7	0.8	2.0	-1.1	-0.7	0.3	0.4	-1.4	-0.5	-1.2	0.9	-0.9	-0.3	-1.1
Eye problems/disorders: Cataract	0.4	0.5	1.4	-0.0	-0.6	-1.1	-1.2	-1.2	-0.4	-0.2	0.7	-0.0	-0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	7.8	2.5	1.2	-0.4	0.6	0.7	-1.6	1.9	-1.1	2.4	2.8	2.3
Medication for cholesterol	1.4	2.1	4.4	-2.1	-0.3	2.0	1.3	0.8	0.5	-1.4	1.3	-1.7	-2.0	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.3	1.0	1.0	-1.8	-0.6	0.3	0.4	0.8	-0.6	0.6	1.5	1.0
Back pain experienced in last month	2.0	2.9	8.7	-0.3	-2.6	0.6	-2.8	-3.0	-1.5	-0.9	0.6	-0.8	-0.5	-2.0
Mineral and other dietary supplements	0.8	1.1	2.7	0.1	-1.6	1.3	1.3	-1.2	1.4	-0.3	-1.0	-0.5	-0.2	-1.2
Breast cancer (self-reported)	0.7	0.9	2.7	-0.5	1.1	0.0	1.2	1.6	-1.4	-0.4	1.2	0.1	0.6	0.4
Asthma (self-reported)	0.4	0.7	4.0	-0.2	-0.2	-2.0	-1.1	-0.5	-0.8	-0.7	1.0	-0.1	-0.2	-0.3
Osteoporosis (self-reported)	0.3	0.3	0.6	-0.6	0.7	-0.3	-0.7	-0.5	0.7	-0.5	-0.2	-0.7	-0.7	-0.5
Osteoarthritis (self-reported)	0.4	0.6	2.5	-0.4	1.1	0.1	1.6	1.0	-0.2	0.2	0.6	0.1	-0.7	0.9
Medication: Aspirin	0.5	0.6	3.1	-0.5	-0.3	-0.7	-1.7	-0.2	-1.0	-0.3	1.3	0.2	-0.2	0.5
Medication: Gliclazide	0.8	0.9	1.9	1.2	-0.4	-0.8	-0.6	-1.1	-1.1	1.1	-0.5	1.1	1.4	0.2
Illnesses of father: None of the above (group 1)	1.2	1.5	7.6	-0.6	0.9	1.4	1.1	2.8	1.1	-1.0	-0.2	-0.9	-0.9	-0.5
Smoking status: Current	0.9	1.4	5.4	1.0	-0.1	-0.7	2.3	-0.8	1.4	1.1	-1.2	0.9	1.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	2.1	0.5	0.7	1.1	-1.2	0.5	0.6	0.5	-1.5	0.2	0.9	-0.3
Whole body water mass	0.2	1.4	4.6	1.3	0.8	-0.6	-2.1	-0.1	0.2	1.3	-0.9	1.1	1.2	1.6
Leg predicted mass (right)	0.3	1.5	5.4	1.3	0.3	-1.1	-2.3	-0.5	-0.4	1.2	-0.3	1.2	1.6	1.5
Arm fat mass (left)	1.1	4.6	12.8	2.7	-0.7	-3.6	-1.1	0.2	-0.7	2.5	-0.9	2.7	3.2	2.1
Number of self-reported non-cancer illnesses	0.8	1.3	4.3	0.5	-0.8	-2.1	-0.0	-1.2	-1.5	0.7	0.3	1.3	1.1	1.5
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.6	0.6	-0.1	0.9	0.9	0.5	0.6	-0.4	0.5	1.0	0.6
Miserableness	1.1	1.9	4.7	2.2	-0.7	0.3	-1.4	-1.3	-0.1	1.8	-1.3	2.1	1.6	0.9
Guilty feelings	1.0	1.5	4.3	1.4	-1.5	-0.4	-1.3	-2.1	0.3	0.9	-1.9	0.6	1.2	-0.7
Wears glasses or contact lenses	3.5	4.0	8.8	-2.8	0.6	1.3	-1.0	-0.1	-1.8	-3.0	2.7	-2.2	-2.4	-1.8
Ever taken oral contraceptive pill	0.3	0.4	0.9	-0.4	-0.3	0.9	0.4	1.0	0.8	-0.6	-0.8	-0.6	-0.1	-0.3
Hearing aid user	2.2	2.5	5.3	-2.2	0.7	2.1	-1.1	0.0	1.3	-1.7	0.7	-2.1	-2.3	-1.3
Mother’s age at death	1.2	1.5	5.6	0.7	2.3	-0.3	-2.4	0.3	-1.4	-0.0	1.1	0.5	0.5	1.0
Financial situation satisfaction	0.4	0.6	2.0	1.4	-0.4	-0.2	-0.2	0.9	0.4	0.7	-1.1	0.6	0.8	0.4
Tinnitus: Yes, now most or all of the time	1.5	1.7	4.7	1.6	0.7	-0.7	0.3	-0.7	1.5	2.2	-1.8	1.6	0.8	1.3
Commuting to job workplace: Public transport	2.3	2.8	9.6	-1.2	-1.1	1.0	-2.2	-1.7	0.7	-1.4	-0.7	-2.0	-1.4	-3.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.3	-0.9	-0.0	-0.3	-0.5	-1.1	-1.1	-0.8	1.1	-0.2	-0.3	0.1
Medication: Blood pressure	1.0	1.9	4.9	1.8	-0.3	-0.8	-1.3	-2.2	-0.2	1.3	-1.1	1.8	1.9	0.9
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.9	-0.0	-0.3	-0.5	-1.4	-1.1	-0.6	0.1	-0.0	0.4	0.1	0.2
Supplements: Fish oil (including cod liver oil)	0.6	0.8	4.4	-0.2	0.4	-2.1	-0.9	0.6	-1.1	0.7	0.8	0.8	-0.0	0.5
High cholesterol (Self-reported)	0.6	1.0	1.7	-1.3	-0.8	0.4	-0.7	-0.9	-0.4	-1.3	1.3	-1.0	-1.2	-1.3
Medication: Bendroflumethiazide	2.1	3.3	10.0	1.4	-2.2	-1.8	-2.7	-3.2	-1.4	1.1	-0.2	1.5	1.8	0.3
Medication: Paracetamol	0.6	0.9	3.3	1.1	-1.4	-1.8	-0.5	0.0	-1.1	0.6	-0.5	1.0	0.9	-0.1
Medication: Lisinopril	0.2	0.3	2.2	-0.3	-0.2	-0.5	0.4	-1.5	0.5	0.1	0.0	-0.0	0.4	-0.0
Medication: Atorvastatin	1.2	1.5	3.5	-1.3	-1.5	-0.5	-1.4	0.2	-1.2	-1.1	1.9	-0.5	-1.6	-1.0
Illnesses of father: High blood pressure	0.2	0.2	0.9	0.2	-0.1	-0.1	0.1	-0.9	0.5	0.5	-0.6	0.2	0.7	0.2
Alcohol drinker status: Never	0.4	0.5	1.6	1.1	-0.2	-0.1	-0.2	1.2	0.5	0.4	-1.2	0.4	0.8	0.2
Ever smoked	0.3	0.5	2.3	0.2	0.3	1.5	-0.7	0.8	-0.5	-0.3	1.1	0.2	0.4	0.1
Basal metabolic rate	0.3	1.8	4.5	1.5	0.5	-1.2	-2.1	-0.1	-0.1	1.5	-0.8	1.4	1.6	1.8
Leg fat percentage (left)	1.0	3.5	15.4	2.0	-1.3	-3.9	0.0	-0.4	-0.4	1.8	-1.0	2.2	2.3	1.6
Arm fat-free mass (left)	0.3	1.7	3.9	1.6	0.9	-1.0	-2.0	-0.3	0.1	1.6	-1.1	1.4	1.4	1.8
Number of operations (self-reported)	0.9	1.3	4.7	-0.7	2.2	0.7	-0.6	1.4	-1.4	-1.2	1.2	-0.9	-0.3	-0.6
Average weekly beer plus cider intake	1.1	1.6	4.1	-1.4	0.3	0.7	1.3	0.1	2.0	-0.8	-1.0	-1.7	-1.7	-1.2
Irritability	0.5	0.9	2.0	1.4	0.3	0.3	-1.1	-0.3	-0.4	1.3	-1.0	1.3	1.3	0.3
Risk taking	0.4	0.5	1.8	-0.6	1.4	-0.1	0.4	0.8	0.1	-1.1	0.0	-1.1	-0.5	-0.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	3.8	0.2	1.9	0.4	0.5	0.7	1.1	0.3	-1.2	-0.1	-0.1	0.2
Fractured/broken bones in last 5 years	0.9	1.2	5.3	-1.0	-0.6	-0.1	-2.3	-0.7	-0.6	-1.2	1.4	-0.8	-1.0	-0.9
Age started oral contraceptive pill	0.4	0.5	2.0	-0.2	-0.3	-0.2	-1.4	-0.4	-1.4	-0.7	0.6	-0.2	-0.4	-0.9
Diastolic blood pressure, automated reading	1.4	4.4	21.6	-0.7	0.1	2.0	-0.4	-4.6	2.7	-0.3	-3.2	-1.8	-1.0	-1.0
Ever depressed for a whole week	0.6	0.7	2.0	0.7	-1.3	-1.3	0.1	-1.4	-1.0	0.2	-0.2	0.6	0.6	-0.5
Unable to work because of sickness or disability	0.4	0.6	2.0	0.6	-0.7	-0.3	0.2	0.0	1.3	1.0	-1.4	0.4	0.4	0.5
Commuting to job workplace: Cycle	1.3	1.5	4.5	-0.3	-0.3	0.6	-1.8	-1.6	-1.7	-1.4	0.1	-1.2	-0.2	-2.1
Myopia	1.5	2.2	4.8	-1.5	2.0	2.0	1.1	0.3	0.8	-2.2	0.3	-2.2	-1.4	-0.8
Vascular/heart problems diagnosed by doctor	0.7	2.0	8.8	-0.4	1.6	-0.1	1.7	3.0	1.8	-0.5	-1.0	-1.1	-1.2	-0.4
Cholesterol lowering medication	0.8	1.2	3.6	1.4	-0.0	-0.6	-1.9	-1.3	-1.5	0.8	0.1	1.2	1.2	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.1	1.1	0.7	-0.6	1.4	0.5	0.5	1.1	-1.2	1.1	1.7	1.8
Pain experienced in last month	0.4	0.7	2.2	-0.9	0.7	0.2	1.5	0.6	1.0	-1.0	0.5	-1.1	-0.8	-0.3
Supplements: Calcium	1.5	1.6	4.1	1.2	0.6	-2.0	-0.9	0.7	-1.8	1.2	-0.1	1.2	1.1	1.7
Basal cell carcinoma (self-reported)	0.6	0.7	2.0	-0.1	0.6	-0.6	0.4	1.1	-1.4	0.0	1.0	0.9	0.4	1.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.8	0.9	-1.7	-0.3	-0.8	0.7	-1.1	1.0	0.1	1.6	0.8	1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	0.3	-0.1	1.1	-0.8	0.8	-0.9	0.4	0.3	0.4	0.5	0.1
Heart disease (siblings)	1.5	1.8	3.5	1.5	-1.7	-1.0	-1.3	-0.9	-1.4	1.5	-0.4	1.9	1.8	0.7
Alcohol drinker status: Previous	0.8	1.0	2.8	0.4	0.7	1.2	1.4	0.3	1.5	1.1	-1.7	0.3	0.2	0.4
Pack years of smoking	1.5	2.3	8.4	0.5	-2.2	-0.5	1.7	-0.4	2.4	1.4	-2.9	0.3	-0.3	-0.2
Impedance of whole body	0.3	1.5	6.4	-1.6	-0.4	0.0	1.2	1.3	-1.6	-1.1	2.5	-0.2	-0.9	0.3
Leg fat mass (left)	0.9	3.4	12.7	2.0	-1.1	-3.6	-0.5	-0.1	-0.3	2.0	-1.1	2.1	2.5	1.9
Arm predicted mass (left)	0.3	1.7	4.4	1.5	1.2	-0.9	-2.1	-0.2	0.2	1.4	-1.0	1.3	1.4	1.8