TWAS hub - MLF2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1620	0.0510	1.7e-04	0.132	NA	0.099	NA	0.121	6.9e-11	NA	1.9e-08	NA	4.4e-10
2	GTEx	Esophagus Mucosa	0.0860	0.0400	8.5e-03	-0.001	NA	0.011	NA	0.002	3.8e-01	NA	5.4e-02	NA	2.1e-01
3	GTEx	Nerve Tibial	0.1963	0.0763	4.0e-03	0.038	NA	0.038	NA	0.034	1.0e-03	NA	1.0e-03	NA	1.8e-03
4	GTEx	Pancreas	0.1230	0.0540	6.2e-03	0.038	NA	0.010	NA	0.028	1.0e-02	NA	1.2e-01	NA	2.5e-02
5	METSIM	Adipose	0.1406	0.0456	9.1e-05	0.015	0.027	0.030	0.022	0.021	2.3e-03	5.6e-05	2.2e-05	2.6e-04	3.0e-04
6	ROSMAP	Brain Pre-frontal Cortex	0.0966	0.0293	2.8e-06	0.052	0.026	0.050	0.035	0.063	3.0e-07	2.1e-04	4.3e-07	2.1e-05	1.6e-08
7	TCGA	Colon Adenocarcinoma	0.1870	0.0970	5.4e-03	0.008	0.040	0.063	NA	0.036	1.0e-01	2.4e-03	1.5e-04	NA	3.5e-03
8	TCGA	Lung Adenocarcinoma	0.0351	0.0167	5.3e-04	0.040	0.036	0.043	NA	0.041	1.7e-05	4.5e-05	8.6e-06	NA	1.3e-05
9	TCGA	Prostate Adenocarcinoma	0.1002	0.0417	2.5e-07	0.056	0.059	0.074	NA	0.081	1.5e-06	7.9e-07	3.2e-08	NA	8.6e-09
10	TCGA	Testicular Germ Cell Tumors	0.1290	0.0620	1.5e-03	0.068	0.054	0.038	NA	0.053	2.1e-03	5.6e-03	1.7e-02	NA	5.8e-03
11	TCGA	Thyroid Carcinoma	0.0420	0.0190	2.2e-04	0.029	0.049	0.036	NA	0.037	7.8e-04	1.5e-05	1.7e-04	NA	1.4e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Hearing difficulty/problems with background noise	7.6	12.1	22.8	2.0	2.0	-4.5	-4.7	1.0	-4.8	-0.9	-3.9	-3.9	-4.1	-3.4
Medication: Seretide 50 evohaler	6.8	7.9	11.7	-1.6	-3.2	3.3	3.3	-0.3	3.4	1.1	3.2	3.1	2.9	3.2
Financial situation satisfaction	5.4	6.7	12.2	1.5	1.8	-3.5	-3.5	1.4	-2.7	-1.4	-2.6	-2.9	-2.5	-3.3
Supplements: Zinc	4.5	4.9	9.1	1.2	1.6	-3.0	-2.7	0.6	-2.4	0.9	-2.9	-2.8	-2.0	-2.3
Had other major operations	4.5	5.5	10.6	0.6	1.1	-3.3	-3.0	1.3	-2.6	-1.2	-3.1	-2.9	-1.9	-2.7
Age at first live birth	4.5	8.0	15.1	-3.5	-1.0	3.0	2.8	-2.0	3.7	1.4	2.4	3.5	2.3	3.9
Medication: Ramipril	4.4	5.7	8.4	2.9	2.1	-2.5	-2.9	2.4	-2.5	0.7	-2.6	-2.9	-1.3	-2.4
Allergy or Eczema	4.2	11.2	20.9	1.1	1.8	-4.6	-4.5	0.7	-3.9	-2.2	-3.8	-3.6	-4.2	-3.4
High blood pressure (mother)	4.2	5.9	14.6	1.8	1.0	-3.8	-2.8	0.9	-2.2	-1.1	-2.4	-3.1	-2.9	-2.9
Medication: Omeprazole	4.2	5.0	8.5	2.7	1.8	-2.2	-2.0	-0.1	-2.6	-0.1	-2.6	-2.9	-2.2	-2.8
Hearing difficulty/problems: Yes	3.8	5.8	16.1	-0.1	1.3	-3.8	-4.0	0.3	-2.6	-0.7	-2.9	-2.5	-2.5	-2.0
Exposure to tobacco smoke at home	3.7	4.2	8.9	1.0	0.9	-2.7	-1.8	-0.5	-2.4	-2.6	-1.8	-2.4	-1.6	-3.0
Hayfever, allergic rhinitis or eczema	3.5	7.5	13.1	1.2	1.1	-3.6	-3.2	0.3	-3.2	-2.5	-3.0	-3.3	-3.5	-2.9
Qualifications: O levels/GCSEs or equivalent	3.5	5.6	12.0	0.7	1.5	-3.5	-3.0	-0.3	-1.0	-0.6	-3.4	-3.0	-3.2	-2.4
Suffer from ‘nerves’	3.4	5.4	11.4	0.8	0.8	-3.4	-3.3	1.3	-3.1	-1.3	-2.5	-2.6	-1.7	-2.5
Medication: Ventolin 100micrograms inhaler	3.2	4.0	7.9	-0.6	-0.1	2.6	2.6	0.7	2.2	0.3	2.5	2.0	2.7	2.8
Nervous feelings	3.1	5.7	15.7	1.1	-0.1	-2.6	-3.1	0.6	-4.0	-0.3	-2.5	-2.6	-2.0	-3.5
Supplements: Glucosamine	3.0	4.0	8.1	-1.6	-1.3	2.8	2.0	-1.0	1.6	2.8	0.6	2.0	2.2	2.6
Number of treatments/medications taken	2.9	5.1	7.9	1.9	2.4	-2.7	-2.5	2.4	-2.4	-1.3	-2.5	-2.8	-1.5	-2.1
Basal cell carcinoma (self-reported)	2.9	3.4	8.1	2.8	1.1	-1.2	-1.0	1.4	-1.7	-1.0	-2.3	-2.5	-1.8	-2.3
Age at First Birth	2.6	3.8	9.2	-3.0	-0.9	1.8	1.7	-1.2	1.5	-0.4	2.7	3.0	1.4	1.9
Happiness	2.6	3.1	8.3	0.3	2.9	-2.5	-2.7	0.7	-0.8	-0.5	-2.2	-1.4	-1.7	-1.1
Number of operations (self-reported)	2.6	3.8	5.7	2.1	2.1	-1.4	-1.8	1.3	-2.2	-1.5	-2.2	-2.3	-1.8	-2.4
Eye problems/disorders: None of the above	2.5	2.9	6.2	-2.1	-1.3	1.3	1.4	-1.0	2.3	0.9	2.0	2.1	1.1	2.5
Overall health rating	2.5	5.3	9.0	2.7	2.6	-2.5	-2.3	1.3	-2.3	-2.0	-1.8	-2.9	-1.2	-3.0
Medication: Omeprazole (e.g. Zanprol)	2.5	3.1	6.1	2.4	1.8	-1.5	-1.3	-0.5	-1.4	0.0	-2.3	-2.5	-2.1	-1.8
Verbal and Numeric Reasoning (VNR)	2.3	5.5	9.8	1.3	0.2	-2.8	-2.7	1.9	-1.7	-2.2	-3.1	-2.8	-2.5	-2.8
Tense / ‘highly strung’	2.3	3.7	7.4	1.7	-0.1	-1.9	-2.0	1.1	-2.5	-1.1	-2.2	-2.4	-1.8	-2.7
Medication: Gliclazide	2.3	2.6	6.4	2.5	1.1	-1.1	-0.9	1.1	-1.3	-1.8	-1.3	-2.1	-1.4	-2.1
Unable to work because of sickness or disability	2.3	3.0	4.9	1.6	1.5	-2.2	-1.9	-0.2	-1.5	-1.7	-1.9	-2.1	-1.1	-2.2
Qualifications: None of the above	2.2	4.8	17.9	0.4	0.4	2.9	2.3	-0.3	1.2	1.5	2.6	2.1	4.2	2.4
Wears glasses or contact lenses	2.2	2.5	5.2	0.1	-1.2	-1.9	-1.6	-2.3	-1.8	-0.5	-1.4	-1.8	-1.4	-2.0
Medication: Metformin	2.1	2.9	5.2	1.9	0.5	-2.1	-1.6	2.1	-1.4	-1.3	-1.4	-2.3	-1.4	-2.0
Taking other prescription medications	2.1	3.2	4.7	1.6	1.3	-1.9	-1.9	1.8	-1.6	-1.7	-1.9	-2.2	-1.8	-1.8
Impedance of arm (left)	2.1	9.8	18.1	-3.1	-2.4	2.9	3.3	-2.3	2.6	2.4	4.3	3.9	3.2	3.5
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	7.8	-1.0	-0.8	1.8	1.5	0.2	2.8	0.6	0.6	1.4	2.3	2.6
Heart disease (siblings)	2.1	2.6	8.2	0.3	-0.8	0.9	1.1	2.8	1.5	1.6	0.9	0.8	2.9	2.0
Ulcerative Colitis (UC)	2.0	3.8	7.8	-2.1	0.9	2.0	2.0	-2.5	1.4	-0.7	2.8	2.7	1.1	1.7
Diabetes (self-reported)	2.0	3.1	6.7	2.6	1.9	-1.5	-1.5	1.8	-1.1	-0.9	-2.1	-2.3	-1.0	-1.9
Commuting to job workplace: Walk	2.0	2.2	5.9	1.8	0.9	-1.5	-1.6	-0.9	-0.4	0.6	-2.4	-2.0	-1.5	-1.5
Worry (Nagel 2018)	1.9	4.0	13.6	0.5	-0.6	-2.3	-2.7	0.3	-3.7	-0.7	-1.4	-1.8	-1.6	-3.0
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.1	-0.9	-1.0	1.7	2.0	0.2	0.9	0.9	2.0	1.6	1.9	1.8
Illnesses of father: Heart disease	1.9	2.6	5.6	2.0	0.9	-1.4	-1.1	1.1	-1.6	0.1	-2.0	-2.2	-1.6	-2.4
Risk taking	1.9	2.8	5.1	0.7	-2.0	2.1	2.1	1.0	2.3	2.2	0.9	0.8	1.3	1.9
Systolic Blood Pressure	1.8	9.2	17.6	3.4	1.7	-3.5	-2.8	4.2	-3.7	-0.7	-2.0	-3.6	-1.4	-3.9
Ever had hysterectomy (womb removed)	1.8	2.0	4.9	2.2	1.3	-1.4	-1.2	0.1	-0.3	-0.7	-2.0	-2.1	-0.8	-1.7
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	3.5	1.2	1.4	-1.4	-1.2	0.7	-1.8	-0.6	-1.5	-1.9	-1.7	-1.5
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	5.5	0.5	1.5	-2.2	-2.3	1.6	-2.0	-1.1	-1.8	-2.1	-0.7	-1.7
Diabetes diagnosed by doctor	1.8	2.9	5.7	2.4	1.6	-1.6	-1.3	2.2	-1.0	-1.1	-1.9	-2.3	-0.8	-1.8
Number of self-reported non-cancer illnesses	1.8	3.2	5.9	0.7	0.4	-2.2	-1.9	2.1	-1.8	-2.4	-1.8	-2.0	-1.4	-2.0
Ever depressed for a whole week	1.8	2.3	5.3	0.4	1.0	-2.3	-2.1	-0.5	-1.0	-2.0	-1.6	-1.6	-1.3	-1.4
Major Depression (MDD)	1.7	2.0	4.0	0.4	0.2	2.0	1.8	0.0	1.5	1.9	1.3	1.4	1.6	1.7
LDL Cholesterol	1.7	2.8	7.3	-0.4	-2.3	2.3	2.7	0.3	0.7	0.3	2.5	1.7	1.5	0.6
Current tobacco smoking	1.7	2.8	6.6	1.5	1.1	-2.0	-2.6	-1.1	-1.2	-0.6	-1.8	-1.9	-1.5	-2.1
Impedance of arm (right)	1.7	8.1	15.5	-2.7	-2.6	2.5	3.1	-1.6	2.7	1.8	3.9	3.5	2.8	3.3
Blood clot in the leg (DVT)	1.7	2.1	6.2	-0.9	-0.2	1.7	1.4	0.1	2.5	0.6	0.5	1.3	1.9	2.4
Exposure to tobacco smoke outside home	1.7	2.3	4.9	1.2	0.9	-2.2	-1.4	1.8	-1.8	-1.1	-0.4	-1.5	-1.1	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.8	1.1	1.9	-1.1	-1.4	-0.2	-0.9	-1.4	-1.9	-1.6	-2.0	-1.6
Medication: Blood pressure	1.7	3.0	7.3	1.7	1.4	-1.8	-1.9	1.8	-1.1	0.5	-2.7	-2.1	-1.8	-1.5
Hypertension (Self-reported)	1.7	4.8	11.8	3.4	1.2	-1.9	-1.4	1.7	-2.3	-0.6	-2.3	-3.0	-1.4	-3.0
Financial difficulties in last 2 years	1.6	2.1	5.6	1.5	1.0	-0.9	-0.9	2.4	-2.0	-1.6	-1.0	-1.3	-0.8	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	3.9	0.5	1.3	-2.0	-1.9	1.2	-1.2	-1.5	-2.0	-1.8	-1.9	-1.0
Angina (self-reported)	1.6	2.1	6.2	1.6	2.5	-1.3	-1.9	2.0	-1.0	0.5	-1.1	-1.3	-0.3	-0.8
Smoking status: Current	1.6	2.6	6.2	1.3	1.1	-2.0	-2.5	-1.5	-1.1	-0.6	-1.5	-1.8	-1.4	-2.0
Impedance of whole body	1.6	8.0	15.9	-2.0	-2.6	3.0	3.4	-1.7	2.0	1.9	4.0	3.2	3.4	2.8
Blood Red Count	1.5	14.2	26.7	0.3	3.8	-5.2	-5.1	0.8	-3.0	-3.0	-4.2	-3.6	-4.5	-4.4
Type 2 Diabetes (T2D) (2018)	1.5	2.8	5.5	2.3	1.1	-1.7	-1.0	2.3	-1.0	-1.2	-1.8	-2.3	-0.8	-1.8
Qualifications: CSEs or equivalent	1.5	2.0	5.7	-1.1	2.3	-2.4	-1.8	-0.3	-0.6	-0.9	-0.3	-0.3	-2.0	-1.0
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	4.3	-0.1	-1.1	-1.8	-1.9	-0.4	-0.8	-1.8	-1.7	-1.3	-2.1	-0.7
Prospective memory result	1.5	1.8	5.6	-1.0	-0.1	1.6	1.2	-0.2	1.4	0.9	1.2	1.7	2.4	1.5
Chest pain or discomfort	1.5	2.1	8.5	2.9	0.7	0.7	0.8	2.8	-1.2	0.4	-0.2	-1.3	1.3	-0.7
Handedness (chirality/laterality): Left-handed	1.5	1.9	4.6	-2.1	1.2	0.9	0.6	0.8	1.4	1.0	1.2	2.0	-0.1	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	4.1	-0.7	-1.4	-1.6	-0.8	-1.8	-1.0	-2.0	-0.7	-0.8	-0.9	-1.5
Eye problems/disorders: Cataract	1.5	1.7	4.3	1.3	2.1	-1.1	-1.5	0.9	-1.9	0.6	-1.1	-1.4	-0.4	-1.0
Fractured/broken bones in last 5 years	1.5	1.9	4.2	1.5	0.5	-1.1	-1.4	2.0	-1.2	-1.6	-1.7	-1.5	-1.1	-1.1
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	4.5	1.7	1.5	-0.9	-1.1	1.9	-0.9	0.3	-2.1	-1.8	-0.1	-0.7
Systolic blood pressure, automated reading	1.4	4.1	10.5	2.6	1.4	-1.7	-1.6	1.9	-3.2	-0.4	-1.6	-2.5	-0.3	-2.8
Angina	1.4	1.8	4.9	1.7	2.2	-1.2	-1.7	2.0	-0.8	0.5	-0.9	-1.2	-0.2	-0.8
Townsend deprivation index at recruitment	1.4	1.9	3.0	1.1	1.5	-1.7	-1.6	-0.0	-1.5	-1.3	-1.3	-1.5	-1.3	-1.7
Average weekly fortified wine intake	1.4	1.7	5.0	0.6	1.3	-1.5	-2.1	0.4	-0.5	-0.3	-2.2	-1.4	-1.0	-1.1
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	6.8	2.6	0.1	0.1	-0.0	1.2	0.4	1.2	-2.2	-1.7	-0.7	-0.2
Noisy workplace	1.4	1.8	4.7	0.2	1.8	-1.2	-1.1	-0.1	-1.9	-2.2	-1.4	-1.1	-1.2	-1.1
Chronic bronchitis/emphysema (mother)	1.4	1.7	4.8	0.2	-2.0	1.1	2.2	-1.3	0.9	-1.4	1.7	0.7	0.5	0.0
Supplements: Vitamin C	1.4	1.7	4.1	0.7	0.2	-1.9	-1.8	-0.1	-1.2	-0.2	-1.2	-1.6	-2.0	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.9	1.2	0.6	-1.1	-1.2	0.6	-2.0	-1.0	-1.4	-1.6	-1.1	-1.6
Mood swings	1.4	2.5	11.2	-3.4	0.1	-0.5	-0.2	-0.9	0.9	2.0	1.6	1.8	1.4	1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	5.2	1.3	2.0	-0.9	-1.2	2.3	-0.8	0.9	-1.3	-1.2	-0.4	-0.2
Cardiovascular Disease	1.3	4.3	15.5	3.9	1.9	-1.5	-0.4	2.6	-1.6	-0.4	-1.8	-2.7	-0.3	-2.4
High blood pressure	1.3	3.7	9.6	3.1	1.1	-1.6	-1.2	1.4	-2.1	-0.6	-1.8	-2.5	-0.9	-2.8
Stomach or abdominal pain in last month	1.3	1.6	3.4	0.9	0.5	-1.0	-1.1	0.7	-1.6	-0.3	-1.7	-1.5	-1.5	-1.8
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.0	0.8	2.0	-1.4	-1.7	-1.2	-0.7	-0.3	-1.6	-1.4	-0.5	-1.0
High blood pressure (siblings)	1.3	1.8	5.9	0.3	0.7	-2.4	-1.8	1.0	-1.4	1.4	-1.1	-1.4	-1.2	-1.0
Number of full sisters	1.3	1.6	7.5	1.5	-1.5	1.1	1.4	2.7	0.6	-0.3	1.2	0.2	0.6	0.3
Leg pain on walking	1.3	1.7	3.6	0.9	1.5	-1.5	-1.8	-0.1	-1.9	-0.1	-1.6	-1.7	0.5	-0.3
Illnesses of father: None of the above (group 1)	1.3	1.6	2.8	-0.6	-0.6	1.5	1.0	-1.3	1.3	1.3	1.6	1.5	1.2	1.7
Triglycerides	1.2	2.0	5.5	1.7	0.5	-1.4	-1.7	0.2	-2.3	-0.3	-0.5	-1.4	-1.1	-2.3
Chronotype (morning person)	1.2	2.9	6.6	-1.9	-0.2	2.2	2.0	0.1	2.3	0.5	1.1	2.2	1.1	2.6
Diabetes (mother)	1.2	1.5	6.4	2.5	0.2	-0.6	-0.1	1.5	-0.6	-1.1	-1.2	-1.7	-0.5	-1.1
Health satisfaction	1.2	1.5	7.5	0.7	2.7	-1.4	-1.3	0.4	-0.1	-1.2	-1.0	-1.2	-0.6	-0.9
Medication: Ibuprofen	1.2	1.4	4.2	-1.7	0.3	0.2	-0.5	2.1	0.7	1.6	0.6	1.2	1.6	1.1
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.3	-1.7	0.1	0.7	0.8	-2.1	1.3	0.4	1.3	1.7	0.9	1.0
Illnesses of father: High blood pressure	1.2	1.5	4.1	-0.0	0.3	-2.0	-1.6	0.5	-0.7	-1.2	-1.3	-1.2	-1.7	-1.0
Fasting Glucose	1.1	1.3	7.3	2.7	-1.4	0.5	-0.0	0.4	-0.7	1.3	-0.7	-1.0	-0.4	-1.1
Blood Platelet Count	1.1	12.3	25.4	3.6	4.2	-3.5	-3.0	-2.2	-4.7	-1.7	-2.4	-4.0	-2.7	-5.0
Hand grip strength (right)	1.1	3.1	11.1	-0.8	0.8	2.3	1.8	0.5	3.3	-0.0	1.5	2.3	0.3	2.4
Medication: Levothyroxine sodium	1.1	1.9	6.4	-0.8	1.0	-2.5	-1.8	1.6	-0.7	-1.3	-1.0	-0.8	-1.4	-0.9
Chronic bronchitis/emphysema (father)	1.1	1.3	4.6	1.4	0.4	2.1	1.5	1.2	0.6	0.5	1.2	0.6	1.2	0.4
Falls in the last year	1.1	1.6	5.8	-0.8	-2.4	0.6	1.3	-1.9	0.5	-0.7	1.0	0.7	1.7	0.2
Lung cancer (father)	1.1	1.3	2.8	-0.1	-1.4	1.1	1.2	-0.4	1.5	0.3	1.2	0.8	1.7	1.4
Mouth/teeth dental problems: Loose teeth	1.1	1.4	7.0	-0.4	1.3	-1.1	-0.9	-2.6	-0.5	-0.9	-0.5	-0.3	-0.8	-1.4
Neck or shoulder pain in last month	1.1	1.5	4.0	-0.1	1.9	-2.0	-2.0	-0.8	-1.6	1.0	-0.3	-0.7	-0.0	-0.9
Alcohol intake frequency.	1.1	2.4	7.7	-0.2	1.4	-1.4	-2.1	2.1	-0.9	-0.2	-2.8	-1.3	-2.0	-0.0
Qualifications: nursing, teaching	1.1	1.7	5.5	-1.9	-1.5	0.8	0.9	-0.2	2.3	0.8	-0.1	1.2	-0.3	2.0
Mother’s age at death	1.1	1.4	4.5	0.4	-0.7	2.1	1.4	1.3	0.7	1.2	1.1	0.9	0.6	1.6
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.1	0.9	-0.4	-1.0	-0.9	1.1	-1.2	-1.1	-0.9	-1.5	-1.2	-1.8
Diastolic blood pressure, automated reading	1.1	3.5	7.9	2.4	1.2	-1.8	-1.3	1.9	-2.8	-1.0	-1.1	-2.2	-0.5	-2.8
Myopia	1.1	1.6	4.5	-1.1	1.5	-2.1	-1.7	-0.2	-1.2	-1.1	-0.6	-0.6	-1.4	-1.0
Mean Putamen Volume	1.0	1.2	3.0	-0.5	-0.7	0.6	1.0	-0.7	0.9	1.7	1.3	1.2	1.6	1.0
HDL Cholesterol	1.0	1.7	2.6	-1.6	-1.4	1.6	1.3	-0.6	1.6	0.2	0.8	1.5	1.3	1.4
Waist Hip Ratio (WHR)	1.0	4.6	8.5	2.1	1.8	-1.6	-1.3	2.5	-2.6	-2.9	-1.6	-2.0	-2.2	-2.4
Hand grip strength (left)	1.0	2.7	11.7	-0.3	0.4	2.1	1.5	-0.1	3.4	0.2	1.4	2.0	0.3	2.2
Mouth/teeth dental problems	1.0	1.6	4.1	-1.4	-0.5	1.5	1.5	-2.0	1.3	-0.1	0.9	1.5	0.5	1.2
Allergy	1.0	2.4	3.9	-0.9	-0.3	1.9	1.7	-0.6	1.7	2.0	1.7	2.0	1.8	1.5
Alcohol intake versus 10 years previously	1.0	1.5	2.2	0.3	1.1	-1.3	-1.2	1.2	-1.5	-1.1	-1.5	-1.2	-1.4	-1.3
Mouth/teeth dental problems: Dentures	1.0	1.7	3.6	1.9	0.8	-1.0	-1.2	1.4	-1.6	-0.9	-1.1	-1.6	-0.6	-1.5
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	6.2	-0.5	0.5	-2.5	-1.9	1.5	-1.1	-1.6	-1.1	-1.1	-1.0	-1.4
Worry too long after embarrassment	1.0	1.7	4.2	1.6	-0.4	-1.2	-0.8	1.0	-1.9	2.1	-0.6	-1.6	0.2	-1.4
Migraine (self-reported)	1.0	1.2	3.0	-0.1	1.2	-1.0	-0.8	-1.1	-1.0	-1.7	-0.9	-0.8	-1.4	-1.1
Age at last live birth	1.0	1.4	3.9	-0.9	-1.2	1.0	1.1	-1.7	2.0	0.7	0.4	0.8	0.8	1.4
Long-standing illness, disability or infirmity	1.0	1.6	5.5	0.6	1.7	-1.1	-1.3	2.3	-1.6	0.4	-1.0	-1.2	-0.1	-0.7
Supplements: Calcium	1.0	1.1	2.3	0.5	-0.5	-0.9	-1.1	-0.9	-1.5	0.7	-1.4	-1.3	-1.3	-1.1
Body Mass Index (BMI) (2010)	0.9	1.2	3.0	0.6	0.7	-0.9	-0.9	-1.5	-1.5	0.2	-0.8	-1.1	-1.2	-1.7
HbA1C	0.9	1.0	3.3	1.8	-1.1	1.0	0.8	0.2	0.4	1.6	-0.3	-0.6	1.3	0.2
Lung FVC	0.9	4.4	14.0	-1.4	-0.3	-2.9	-3.7	-1.1	-1.5	-1.6	-1.3	-0.8	-3.6	-1.7
Maternal smoking around birth	0.9	1.2	2.7	1.6	-0.7	-0.9	-0.7	1.5	-1.2	-1.5	-0.2	-1.0	0.1	-1.5
Impedance of leg (left)	0.9	4.3	9.5	-0.3	-1.8	2.5	3.0	-0.5	1.1	1.6	3.1	2.0	3.0	1.7
Fluid intelligence score	0.9	2.0	5.2	0.9	1.1	-1.6	-1.9	0.8	-0.9	-0.7	-2.3	-1.8	-0.9	-1.5
Number of live births	0.9	1.3	6.0	2.4	-0.2	0.1	-0.2	-1.1	-1.3	-0.2	-1.2	-1.6	-0.3	-1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.5	0.2	1.6	-1.2	-1.4	-0.5	-1.1	-0.7	-0.8	-0.4	-1.5	-0.9
Comparative height size at age 10	0.9	5.2	17.2	-0.1	2.5	2.8	2.6	2.2	4.2	-1.3	0.5	2.0	0.3	2.9
Ever taken oral contraceptive pill	0.9	1.0	2.2	0.5	1.0	-1.2	-1.1	0.1	-0.6	0.2	-1.5	-1.0	-1.5	-1.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	8.0	-2.8	-0.7	1.2	0.9	-1.5	1.8	0.5	1.1	2.0	0.2	2.2
Alcohol drinker status: Previous	0.9	1.0	3.3	1.8	0.6	-0.2	-1.0	1.0	-0.4	0.8	-1.3	-1.3	-1.1	-0.2
Alzheimer’s Disease (in mother)	0.8	1.0	3.9	-0.6	-2.0	0.6	0.8	-1.0	1.3	1.1	-0.4	0.4	0.8	0.8
Reaction Time	0.8	1.6	5.0	-2.2	-1.5	-0.7	0.4	-0.8	0.7	-2.0	1.5	1.2	-0.9	0.7
Primary Biliary Cirrhosis	0.8	1.1	7.2	-0.7	-0.4	0.5	0.7	2.7	1.6	0.3	-0.4	0.4	-0.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.7	0.8	-0.7	-0.5	-0.9	-0.8	0.2	1.6	-1.5	-1.2	-0.9	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	2.6	-1.6	1.0	-0.2	-0.8	1.6	0.4	1.4	0.4	0.9	1.1	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.6	1.2	-1.2	-0.4	-0.0	1.6	-1.2	-0.9	-0.4	-1.0	-0.4	-0.8
Pulse rate, automated reading	0.8	2.6	6.1	1.8	1.6	-0.8	-0.4	-0.0	-1.9	-2.0	-1.7	-1.8	-1.4	-2.5
Loneliness, isolation	0.8	1.1	3.3	-1.8	0.1	0.6	0.7	0.1	1.5	-1.0	1.1	1.4	0.8	0.8
Hearing aid user	0.8	0.9	2.3	-1.1	-0.9	0.8	0.9	0.7	0.9	-1.5	1.2	1.1	-0.3	0.7
Intelligence (Savage-Jansen 2018)	0.7	2.3	5.9	1.6	0.9	-1.3	-1.7	1.8	-0.5	-0.2	-2.4	-1.8	-1.4	-1.7
Schizophrenia vs Biploar Disorder	0.7	0.9	2.6	-0.6	1.6	-1.6	-1.6	0.0	0.2	-0.5	-0.6	-0.6	-0.5	-0.5
Crohns Disease (2012)	0.7	1.2	2.2	0.9	-0.7	-1.3	-1.0	0.0	-1.1	-1.0	-1.1	-1.5	-1.3	-1.5
Lupus	0.7	1.1	3.4	-0.9	-0.6	0.5	1.6	0.9	0.1	-0.3	1.8	0.9	1.8	0.0
Neuroticism	0.7	1.6	5.5	-0.6	-0.3	-1.8	-1.8	1.4	-2.4	1.0	-0.2	-0.6	-0.1	-1.2
Medication for hormone replacement therapy	0.7	0.8	2.7	-0.7	-1.0	-0.7	-0.7	0.5	-0.4	-1.5	0.2	-0.0	-1.7	-1.1
Impedance of leg (right)	0.7	3.3	7.7	-0.4	-1.8	2.2	2.5	0.2	0.8	1.3	2.8	1.7	2.4	1.5
Trunk fat percentage	0.7	2.8	5.4	-1.3	0.3	2.1	2.2	-0.8	2.3	0.4	1.4	2.0	1.9	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.5	-0.3	0.4	-1.4	-1.6	1.0	-1.4	-1.2	0.2	-0.5	-1.3	-1.0
Hair/balding pattern: Pattern 2	0.7	0.9	2.7	-0.5	-0.5	1.4	1.6	0.4	0.8	0.3	0.9	1.0	1.0	0.8
Had menopause	0.7	0.9	4.4	0.7	-0.8	-0.8	-0.8	-0.4	-2.1	0.4	-0.0	-0.6	0.5	-1.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	3.3	1.8	0.7	-1.1	-0.4	1.6	-0.4	0.6	-0.1	-1.1	0.1	-0.9
Number of full brothers	0.7	0.8	3.5	0.9	1.9	-0.8	-0.5	0.6	-0.2	0.9	-0.8	-0.9	1.1	-0.1
Emphysema/chronic bronchitis	0.7	0.8	3.7	1.9	0.4	1.0	0.9	1.0	0.1	1.1	0.2	-0.4	0.5	-0.0
Medication for pain relief, constipation, heartburn	0.7	1.3	7.0	-0.2	-1.6	1.3	1.1	-2.7	-0.3	0.4	0.7	0.6	-0.3	0.0
Breast cancer (self-reported)	0.7	0.8	3.0	1.5	0.4	1.3	1.7	0.6	-0.1	0.9	0.7	0.1	0.3	-0.1
Miserableness	0.7	1.2	5.8	-2.4	-0.0	-0.1	-0.1	-0.7	0.9	1.0	1.1	1.5	0.4	1.0
Medication: Paracetamol	0.7	1.1	2.9	-1.7	1.3	-1.6	-1.6	0.6	0.3	-0.3	-1.2	-0.1	-0.1	0.4
Arm fat-free mass (left)	0.7	3.7	9.4	1.8	3.0	-0.2	-1.0	2.5	0.6	-1.8	-3.1	-1.4	-2.4	-0.8
Arm predicted mass (left)	0.7	3.8	9.0	1.9	2.7	-0.3	-1.0	2.5	0.6	-2.0	-3.0	-1.6	-2.5	-1.0
Neuroticism (Nagel 2018)	0.6	1.3	5.1	-0.7	0.0	-1.8	-1.7	0.4	-2.3	0.8	-0.6	-0.8	-0.1	-1.1
Rheumatoid Arthritis	0.6	0.8	2.5	-1.6	1.2	-0.6	-1.1	-1.2	0.3	1.2	-0.5	0.5	-0.5	0.3
Height	0.6	10.9	25.7	-0.4	1.5	5.1	4.2	2.0	4.9	2.4	1.7	3.4	2.2	4.6
Average weekly spirits intake	0.6	0.7	1.7	1.3	0.7	1.1	1.3	-0.1	0.6	0.7	0.6	-0.1	1.3	0.4
Sensitivity / hurt feelings	0.6	1.1	4.7	-2.2	-0.0	-1.1	-0.7	0.9	0.2	1.4	0.7	1.0	0.4	1.1
Relative age of first facial hair	0.6	1.3	3.1	-0.2	-1.6	-1.6	-1.8	-1.0	-0.6	0.1	-1.1	-0.9	-1.3	-0.9
Diabetes (father)	0.6	0.7	3.1	-0.0	0.0	0.5	1.3	1.2	1.8	-0.9	-0.1	0.4	-0.1	0.5
Severe depression (siblings)	0.6	0.7	2.7	0.1	0.6	-0.9	-1.1	0.2	-1.6	-0.3	-0.9	-1.0	-0.3	-1.0
Serious illness, injury or assault to yourself	0.6	0.8	4.2	0.6	1.1	0.1	-0.0	2.1	0.3	0.9	-0.3	-0.3	1.2	0.6
Past tobacco smoking	0.6	1.1	3.2	-0.8	-0.1	-1.5	-1.0	-0.1	-1.2	-0.5	-1.4	-1.0	-1.8	-0.8
Alcohol usually taken with meals	0.6	1.0	5.7	-1.3	-2.4	0.4	0.3	0.3	1.3	-0.7	-0.3	0.7	-0.2	0.4
Trunk fat-free mass	0.6	3.6	9.5	1.5	2.9	-0.2	-1.1	2.6	0.9	-1.5	-3.1	-1.3	-2.6	-0.5
Time employed in main current job	0.6	0.7	2.6	0.3	-1.6	1.1	0.9	-0.5	0.2	0.8	1.0	0.7	0.6	0.4
Trunk predicted mass	0.6	3.6	9.5	1.4	2.9	-0.2	-1.1	2.5	0.9	-1.5	-3.1	-1.3	-2.6	-0.6
Loud music exposure frequency	0.6	0.7	2.8	0.1	-0.9	-0.9	-0.4	-0.5	-0.7	-1.7	-0.3	-0.9	-0.6	-0.9
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	5.2	-0.8	-1.3	0.5	0.3	-2.3	-0.3	0.0	1.5	0.8	0.4	-0.0
Birth weight	0.6	1.3	3.5	0.3	-0.5	1.9	1.3	0.6	1.8	1.4	0.4	0.7	0.7	1.6
Arm fat-free mass (right)	0.6	3.3	8.8	1.8	3.0	-0.0	-0.7	2.4	0.4	-1.6	-2.8	-1.3	-2.1	-0.9
Pulse wave peak to peak time	0.6	0.7	3.2	-1.1	-0.4	0.4	0.7	-0.1	1.8	-0.2	0.3	0.7	-0.6	1.0
Arm predicted mass (right)	0.6	3.0	7.8	1.7	2.8	0.2	-0.5	2.6	0.8	-1.3	-2.7	-1.1	-2.0	-0.6
Smoking status: Previous	0.6	1.0	2.9	0.7	0.1	1.4	1.3	0.6	0.4	-0.0	1.3	0.9	1.7	0.6
Whole body water mass	0.6	3.3	9.4	1.3	3.1	-0.1	-0.9	2.4	1.1	-1.4	-2.8	-1.1	-2.4	-0.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.9	-0.9	-0.4	0.9	0.5	-0.5	0.8	0.7	0.8	1.4	1.2	0.7
Medication: Blood pressure	0.6	1.2	3.3	1.4	0.5	-0.9	-0.2	1.8	-1.1	-1.5	-0.2	-0.9	0.4	-1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.7	4.7	-2.2	0.4	-0.3	-0.5	-1.0	0.4	0.2	0.1	0.7	-0.2	0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.7	-0.0	-0.1	0.2	-0.1	-1.2	-0.5	1.9	-1.6	-0.4	-0.8	0.1
Medication: Bendroflumethiazide	0.6	0.9	3.4	1.2	0.1	0.9	1.4	1.9	-0.3	-0.2	0.1	-0.3	1.3	-0.2
Pain experienced in last month	0.6	1.0	2.6	-0.2	-1.3	1.6	1.5	0.4	1.6	-0.2	0.1	0.8	0.3	0.8
Schizophrenia (2018)	0.5	1.0	2.7	-0.2	-0.0	-1.6	-1.1	0.1	-0.7	-1.0	-1.1	-1.4	-1.5	-0.7
Alzheimer’s Disease (in father)	0.5	0.5	1.6	0.8	-0.7	-0.7	-0.1	1.0	-0.4	-0.1	-0.7	-1.3	-0.6	-0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	3.7	-0.5	-1.9	0.4	0.9	0.1	1.2	0.8	-0.1	0.1	0.7	0.7
Coronary Artery Disease (CAD)	0.5	0.5	2.8	0.4	0.4	-0.4	-0.3	0.0	-1.7	0.5	-0.8	-0.8	0.9	-0.5
Ulcerative Colitis	0.5	0.7	2.8	0.0	1.2	0.5	1.0	-1.2	-0.0	-1.7	0.5	0.4	-0.6	-0.3
Hypothyroidism (self reported)	0.5	1.1	2.9	-0.4	1.1	-1.7	-1.2	0.7	-0.4	-1.5	-0.7	-0.7	-1.0	-1.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.5	0.7	0.7	0.6	1.1	-0.5	0.1	-0.9	0.1	-0.4	1.6	0.0
Relative age voice broke	0.5	0.7	3.4	0.8	-1.8	-0.3	-0.2	-1.0	0.1	0.6	-0.8	-0.9	-0.8	-0.5
Medication: Atenolol	0.5	0.6	4.8	0.8	0.3	-0.4	-0.2	2.2	-0.3	-0.4	0.6	-0.1	0.7	-0.4
Trunk fat mass	0.5	2.2	6.6	-0.8	0.9	2.0	1.9	-0.1	2.6	0.1	0.6	1.6	1.2	1.8
Heart attack	0.5	0.7	2.0	0.0	1.3	0.0	-0.1	1.0	0.1	-0.5	1.4	0.7	1.4	0.2
Pain all over the body in last month	0.5	0.5	1.3	-0.7	-1.0	0.2	0.2	0.9	-0.3	0.4	1.1	0.6	1.1	0.6
Neuroticism score	0.5	1.0	2.3	-0.6	0.0	-1.5	-1.4	1.5	-1.4	1.2	-0.2	-0.3	-0.4	-0.7
Worrier / anxious feelings	0.5	1.0	3.9	-0.2	-0.2	0.4	0.6	1.3	-0.1	1.0	2.0	1.1	1.6	0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	3.2	-1.3	0.4	-0.9	-1.4	-1.2	1.2	0.3	-1.2	-0.1	-1.8	0.2
Medication: Lansoprazole	0.5	0.6	1.5	1.2	0.1	-0.3	-0.6	0.8	-0.9	-1.2	-0.3	-1.0	-0.3	-0.8
Illnesses of mother	0.5	0.6	1.9	-1.0	1.1	1.0	0.1	-0.3	0.5	-1.4	-0.3	0.8	0.1	0.6
Medication: Paracetamol	0.5	0.9	2.8	-1.7	0.9	-1.1	-0.9	1.2	0.9	-0.7	-0.8	0.1	0.0	0.7
Forced vital capacity (FVC), Best measure	0.5	1.8	5.9	-2.4	0.3	0.4	-0.1	0.5	1.8	-1.0	-0.0	1.5	-2.2	1.3
Body fat percentage	0.5	2.1	4.1	-0.8	0.5	2.0	2.0	-0.6	2.0	0.5	1.1	1.6	1.8	1.6
Wheeze or whistling in the chest in last year	0.5	0.9	2.0	1.4	0.2	1.1	1.1	0.4	1.4	0.5	0.9	0.1	1.2	0.4
Qualifications: College or University degree	0.5	1.6	4.6	-0.2	-1.4	-1.0	-0.7	0.3	-0.2	-2.0	-1.5	-1.2	-2.1	-1.5
Medication: Allopurinol	0.5	0.7	2.5	-0.4	1.2	0.6	0.5	1.6	0.1	0.0	1.2	1.0	0.5	0.5
Mean time to correctly identify matches	0.5	1.0	3.5	-1.9	-1.7	-0.8	-0.2	-1.1	-0.2	-0.9	1.0	0.8	-0.3	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.1	-1.2	-0.1	-0.4	-0.5	-1.4	-0.7	-0.4	0.3	0.4	-1.5	-0.4
Knee pain experienced in last month	0.5	0.7	3.8	-0.1	1.9	-0.8	-0.9	-1.2	-0.1	0.5	-0.7	-0.3	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.6	-0.8	-0.5	0.7	0.8	1.4	1.6	-1.5	-0.2	0.7	-1.2	1.0
Whole body fat-free mass	0.5	2.9	8.6	1.2	2.9	-0.0	-0.8	2.2	1.2	-1.3	-2.7	-0.9	-2.2	-0.3
Average weekly red wine intake	0.5	0.8	2.1	1.5	-1.4	0.7	1.0	0.7	1.2	0.5	-0.5	-0.5	0.2	0.3
Medication for cholesterol	0.5	0.8	3.1	-1.0	0.2	0.4	-0.6	-1.8	-0.1	1.8	-0.5	0.3	-0.4	0.9
Back pain experienced in last month	0.5	0.8	3.0	1.1	1.7	-0.9	-0.7	0.1	-0.6	1.1	-0.0	-0.9	0.6	-0.6
Osteoporosis (self-reported)	0.5	0.6	3.7	-0.7	-1.9	0.7	0.6	-0.9	0.3	-0.0	0.5	0.6	0.1	0.6
Commuting to job workplace: Public transport	0.5	0.6	2.6	0.5	-1.0	-0.2	-0.6	0.7	0.7	0.4	-1.6	-0.7	-0.8	-0.3
Medication: Lisinopril	0.5	0.6	3.3	1.1	-0.7	0.7	0.4	1.8	0.2	-0.3	-0.5	-0.2	-0.9	-0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.6	0.1	1.2	-0.2	-0.2	1.1	0.1	-0.8	1.2	0.5	1.3	0.0
Irritable Bowel Disease (IBD)	0.4	0.9	5.6	-0.3	1.0	0.5	0.5	-2.4	0.3	-0.1	1.2	0.8	-0.0	0.1
Schizophrenia (2014)	0.4	0.9	2.4	-0.9	-0.2	-1.6	-0.8	-1.2	-0.9	-0.6	-0.9	-1.1	-1.0	-0.7
Blood White Count	0.4	2.6	8.2	1.6	2.4	-0.5	0.0	-2.9	-2.0	-0.9	-0.1	-1.3	0.2	-2.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	2.4	-1.5	-0.3	-0.5	-0.7	1.2	0.5	0.3	0.4	0.5	0.1	0.9
Leg fat-free mass (left)	0.4	1.9	6.1	0.1	2.5	0.5	-0.1	1.8	1.9	-1.1	-1.7	0.0	-1.6	0.6
Age when periods started (menarche)	0.4	1.0	2.9	0.8	-1.3	1.5	1.5	0.4	0.1	1.7	1.0	0.4	0.8	0.2
Sitting height	0.4	3.1	13.3	-0.6	1.5	2.3	1.7	0.3	3.6	-0.2	0.7	2.1	-0.4	2.1
Leg predicted mass (left)	0.4	1.9	6.7	0.0	2.6	0.5	-0.2	1.8	1.9	-1.0	-1.7	0.1	-1.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	5.5	1.5	0.9	0.0	0.3	0.7	-0.6	2.4	0.4	-0.7	0.5	0.2
Medication: Simvastatin	0.4	0.7	3.1	0.2	0.8	-0.9	-0.5	1.8	0.0	-0.7	-0.9	-0.8	0.4	0.0
Illnesses of siblings	0.4	0.6	2.3	-0.1	0.0	1.5	0.6	-1.2	0.4	-1.5	0.2	0.6	-0.4	-0.1
Father’s age at death	0.4	0.5	1.7	0.8	0.5	-0.4	-0.7	0.6	-0.4	0.5	-1.3	-1.0	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	9.6	-0.7	0.2	-0.5	-0.9	0.8	0.3	-1.2	-0.7	0.1	-3.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	5.2	-1.9	-0.0	-0.1	-0.4	0.4	1.4	-1.2	-0.3	0.9	-2.3	0.7
Pulse wave Arterial Stiffness index	0.4	0.4	2.2	1.0	0.6	-0.2	-0.6	0.1	-1.5	0.1	-0.3	-0.4	0.6	-0.6
Standing height	0.4	4.1	14.7	-0.2	1.5	3.0	2.2	1.8	3.8	-0.1	-0.2	1.9	-0.2	2.7
Ever highly irritable/argumentative for 2 days	0.4	0.5	3.1	-0.4	1.8	-0.4	-0.7	-0.2	0.5	0.8	-0.2	0.4	-0.4	0.4
Gout (self-reported)	0.4	0.6	2.2	0.4	0.9	1.0	1.0	1.5	0.2	-0.3	0.8	0.5	0.7	0.3
Comparative body size at age 10	0.4	1.1	2.5	-0.6	-1.1	1.4	1.4	-0.0	1.6	-0.0	0.7	1.1	1.1	1.0
Number of children fathered	0.4	0.5	2.0	1.4	-0.0	0.9	0.4	0.6	0.6	0.8	0.6	0.1	0.4	0.5
Shortness of breath walking on level ground	0.4	0.5	2.2	1.3	1.5	-0.3	-0.2	0.2	0.3	-0.2	-0.3	-0.6	0.8	0.4
Heart disease (mother)	0.4	0.4	1.3	0.6	-0.2	-0.6	-0.4	1.0	-0.5	-1.1	-0.2	-0.5	-0.9	-0.5
Whole body fat mass	0.4	1.8	5.5	-0.6	1.0	2.0	1.8	0.3	2.4	0.0	0.4	1.4	1.0	1.6
Medication: Aspirin	0.4	0.5	1.8	0.9	0.6	-0.5	-0.4	1.3	1.0	-0.6	-0.3	-0.3	0.3	0.1
Illnesses of siblings: Diabetes	0.4	0.5	2.5	-0.8	0.1	-1.6	-1.1	-0.0	0.0	-0.9	-0.7	-0.2	-0.4	0.2
Friendships satisfaction	0.4	0.5	1.3	0.9	1.1	-0.3	-0.9	0.9	-0.2	0.3	-0.7	-0.6	-0.3	-1.0
Mineral and other dietary supplements	0.4	0.6	2.1	0.1	0.1	-0.5	-0.3	1.4	0.8	-1.4	0.8	0.1	0.8	0.0
High cholesterol (Self-reported)	0.4	0.8	2.7	0.6	-0.0	1.1	1.1	1.1	1.0	0.0	0.3	0.5	1.6	0.7
Basal metabolic rate	0.4	2.4	7.5	0.9	2.7	0.4	-0.3	2.1	1.6	-1.2	-2.3	-0.5	-2.0	0.2
Average weekly beer plus cider intake	0.4	0.5	1.6	1.0	0.2	1.0	0.6	0.1	-0.6	0.7	0.9	0.4	1.3	-0.0
Irritability	0.4	0.6	1.9	-1.4	-1.0	-0.5	-0.9	-0.0	-0.4	1.3	0.5	0.4	0.5	0.5
Age started oral contraceptive pill	0.4	0.4	1.1	0.2	1.0	-0.6	-1.0	-0.7	-0.4	1.0	-0.6	-0.3	-0.5	-0.3
Commuting to job workplace: Cycle	0.4	0.4	1.3	-0.8	0.3	-0.5	-1.1	-0.5	0.6	0.7	-0.9	0.2	-0.7	0.3
Bipolar Disorder (2018)	0.3	0.5	1.8	0.7	0.6	0.9	1.3	-1.3	0.4	0.0	0.3	-0.1	-0.3	0.3
Depressed Affect (Nagel 2018)	0.3	0.6	3.2	-1.8	0.5	-0.9	-1.0	-0.5	-0.4	0.8	-0.2	0.4	-0.1	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.7	-0.1	0.6	0.8	1.3	0.0	0.6	-0.0	0.6	0.4	0.5	0.1
Blood Eosinophil Count	0.3	2.2	13.2	0.3	3.6	0.2	-0.6	-2.2	-1.6	0.7	0.7	-0.0	-0.9	-1.2
Heel T-Score	0.3	2.5	5.8	2.1	2.4	-1.3	-1.4	2.1	-0.9	1.3	-1.2	-1.7	-1.4	-1.0
Vitamin and mineral supplements	0.3	0.5	3.6	0.6	0.8	0.3	0.3	0.3	0.5	0.0	0.2	-0.1	1.9	0.1
Fed-up feelings	0.3	0.5	1.5	-1.1	0.9	-0.9	-0.9	0.2	-0.8	1.2	-0.0	0.1	-0.1	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.6	1.1	-0.9	-1.1	-0.4	-0.2	-0.2	0.5	-0.1	0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	1.1	0.9	-0.5	0.1	1.2	-0.7	0.9	0.1	-0.9	-0.6	-0.3
Multivitamins +/- minerals	0.3	0.4	1.5	-0.7	-0.7	0.6	0.7	-0.9	-0.2	-0.4	0.1	0.6	-1.2	0.1
Waist circumference	0.3	1.2	3.4	0.9	1.1	-0.2	-0.2	1.4	0.3	-1.8	-1.7	-0.9	-1.2	-0.9
Number of incorrect matches in round	0.3	0.5	1.1	-1.0	-0.7	-0.0	-0.3	-0.6	-0.8	0.8	1.1	0.8	0.6	0.2
Forced vital capacity (FVC)	0.3	1.2	7.3	-1.4	0.7	-0.0	-0.5	1.0	0.8	-1.1	-0.1	0.9	-2.7	0.4
Weight	0.3	1.4	5.2	0.2	2.0	1.4	1.0	0.9	2.3	-0.4	-0.9	0.6	-0.5	1.0
Breastfed as a baby	0.3	0.4	1.5	-1.0	-0.4	-0.3	-0.8	0.1	0.5	0.2	-0.5	0.6	-1.2	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.5	-0.5	-1.1	1.0	0.6	0.8	0.0	0.4	1.2	1.1	0.0	0.8
Birth weight of first child	0.3	0.5	1.2	1.0	1.1	-0.4	-0.3	0.8	-0.4	0.8	-0.7	-1.0	-0.6	-0.4
Peak expiratory flow (PEF)	0.3	0.7	3.4	-0.2	0.0	0.3	0.0	0.2	1.5	-1.1	0.4	0.7	-1.8	0.5
Headache pain in last month	0.3	0.5	1.6	-0.8	0.9	-0.5	-0.6	0.5	-0.8	-1.3	-0.5	-0.2	-0.7	-0.5
Medication: Amlodipine	0.3	0.4	1.0	-0.1	0.0	-1.0	-0.6	-0.9	-0.1	-0.2	-1.0	-0.7	-0.2	-0.6
Leg fat mass (right)	0.3	1.0	3.1	0.2	1.7	1.4	1.1	1.0	1.6	-0.3	-0.3	0.6	0.2	0.8
Had major operations	0.3	0.3	1.3	-0.1	0.9	0.2	-0.4	1.2	0.5	-0.1	-0.4	0.1	-0.5	0.5
Family relationship satisfaction	0.3	0.3	1.3	0.1	1.0	-0.3	-0.7	1.1	-0.4	0.7	-0.1	-0.2	0.3	-0.5
Leg fat-free mass (right)	0.3	1.8	6.7	0.2	2.6	0.4	-0.1	1.3	2.0	-1.1	-1.8	-0.0	-1.7	0.6
Arm fat percentage (left)	0.3	1.1	3.2	-0.9	1.0	1.1	1.1	-0.6	1.8	0.2	0.6	1.2	0.8	1.1
Ever had bowel cancer screening	0.3	0.4	1.6	1.3	0.3	-0.3	0.2	0.5	-0.1	0.3	-0.6	-1.1	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	-0.7	-1.1	-0.7	-0.6	0.1	-0.1	0.8	-0.7	-0.4	-1.0	0.0
Asthma (self-reported)	0.3	0.5	1.1	0.4	-0.6	1.1	1.0	0.7	0.2	-0.2	0.9	0.3	0.8	0.8
Medication: Aspirin	0.3	0.4	2.1	0.7	0.5	-0.5	-0.4	1.5	0.9	-0.1	-0.3	-0.2	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.9	-1.7	-0.3	-0.5	-0.2	0.4	-0.2	-0.6	0.3	0.7	-1.5	0.2
Leg predicted mass (right)	0.3	1.8	7.0	0.2	2.7	0.3	-0.2	1.3	1.9	-1.0	-1.8	-0.1	-1.7	0.5
Average weekly champagne plus white wine intake	0.3	0.5	1.1	0.2	-0.5	1.0	1.1	-0.0	1.1	-0.8	0.5	0.7	-0.1	0.5
Guilty feelings	0.3	0.4	3.2	0.3	-1.1	-0.3	0.2	1.8	0.0	0.2	0.4	-0.2	0.4	-0.1
Alcohol drinker status: Never	0.3	0.4	1.8	-0.3	-1.2	-0.1	-0.3	-1.4	-0.1	-0.3	-0.7	-0.1	-0.1	-0.3
Ever smoked	0.3	0.6	1.8	1.0	-0.5	1.1	0.2	0.5	1.3	0.6	0.8	0.6	0.7	0.4
Leg fat percentage (left)	0.3	1.2	2.9	-0.1	0.9	1.7	1.6	-0.6	1.5	0.5	0.8	1.0	1.4	1.0
Cholesterol lowering medication	0.3	0.4	1.5	0.6	0.7	-0.7	-0.5	1.2	-0.0	-0.3	-0.8	-0.6	0.4	-0.2
Pack years of smoking	0.3	0.5	1.5	0.1	0.5	1.2	0.6	-0.2	0.7	-0.4	0.8	0.9	0.9	0.1
Leg fat mass (left)	0.3	1.1	2.9	0.4	1.7	1.5	1.3	0.7	1.7	-0.2	-0.2	0.6	0.4	0.8
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	0.3	0.3	-0.7	-0.0	-0.8	-0.3	-0.8	-0.7	-1.1	-1.3	-0.4
Depression (Nagel 2018)	0.2	0.3	0.9	-1.0	0.5	-1.0	-0.9	-0.2	-0.2	-0.1	0.3	0.0	-0.1	-0.0
Crohns Disease (2017)	0.2	0.5	2.8	0.7	0.4	-0.6	-0.7	-1.7	-0.4	0.3	-0.2	-0.7	-0.3	-0.9
Ovarian Cancer	0.2	0.2	1.1	-0.2	0.2	0.2	-0.7	0.7	-1.1	0.3	-0.1	0.1	0.4	0.1
Smoking Status	0.2	0.6	1.8	1.3	0.0	-0.1	-0.5	-1.2	-0.4	-0.6	-0.0	-0.6	0.7	-1.2
Lung FEV1/FVC ratio	0.2	1.1	2.5	1.6	-1.1	-0.6	-0.4	-1.1	-1.6	0.5	-0.7	-1.4	-0.0	-1.2
Hair Pigment	0.2	6.8	11.7	-2.6	-2.6	2.8	2.9	-0.3	3.3	0.9	2.9	3.1	1.8	3.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	1.1	-0.4	-0.9	0.1	-0.2	-1.1	-0.3	0.2	0.8	0.6	-0.2	0.1
Medication: Co-codamol	0.2	0.3	0.7	0.0	0.8	-0.5	-0.7	-0.3	-0.5	-0.6	-0.5	-0.4	-0.7	-0.2
Pack years adult smoking proportion	0.2	0.3	0.9	0.5	0.7	0.9	0.4	-0.0	0.6	-0.6	0.6	0.7	0.6	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.5	0.3	0.2	0.6	-0.4	0.8	-0.8	0.4	0.5	-0.4	0.2
Arm fat percentage (right)	0.2	1.0	3.6	-0.7	0.8	1.1	1.1	-0.4	1.9	-0.1	0.5	1.1	0.7	1.2
Hip circumference	0.2	0.7	4.5	-0.6	0.3	0.7	0.5	0.3	2.1	-0.2	-0.9	0.4	-0.3	0.6
Pulse rate	0.2	0.4	1.1	-0.1	0.1	1.1	1.0	-0.3	0.5	-0.6	0.8	0.7	0.4	0.0
Medication: Cholesterol lowering	0.2	0.3	1.7	0.2	0.6	-0.5	0.2	0.8	0.5	-1.3	-0.4	-0.5	0.2	0.1
Depression (self-reported)	0.2	0.3	1.2	0.2	-1.1	0.3	0.2	-0.1	0.1	-1.0	-0.4	-0.3	-0.2	-0.3
Arm fat mass (right)	0.2	0.7	3.1	0.0	1.3	0.9	0.8	0.5	1.7	-0.7	-0.4	0.4	-0.2	0.6
Pulse wave reflection index	0.2	0.2	0.6	-0.3	-0.5	-0.3	-0.3	0.3	-0.7	-0.1	0.6	0.1	0.8	0.4
Glaucoma (self-reported)	0.2	0.2	0.8	-0.7	-0.0	-0.0	-0.4	-0.3	0.1	0.6	0.5	0.7	0.9	0.1
Leg fat percentage (right)	0.2	0.8	2.2	-0.1	0.9	1.5	1.3	-0.0	1.2	0.3	0.5	0.8	1.1	0.8
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.6	-0.6	-0.7	-0.8	0.5	-0.0	0.1	0.3	0.2	0.1	0.3
Arm fat mass (left)	0.2	0.7	3.2	-0.2	1.4	0.9	0.8	0.2	1.8	-0.5	-0.3	0.6	-0.1	0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.1	0.6	-0.4	-0.2	-0.2	0.2	-0.5	1.0	-0.3	-0.2	-0.1	-0.2
Medication: Atorvastatin	0.2	0.3	0.6	0.5	0.4	-0.6	0.2	0.8	-0.5	0.1	0.7	-0.2	0.8	-0.8
Neuroticism (2016)	0.1	0.2	0.4	-0.6	0.4	-0.6	-0.3	0.3	0.2	0.6	0.5	0.4	0.4	-0.0
BMI	0.1	0.4	2.2	0.3	1.5	0.1	-0.1	-0.0	0.6	-0.2	-0.7	-0.2	-0.8	-0.7
Respiratory disease	0.1	0.2	1.1	0.2	-0.3	1.1	0.5	-0.0	-0.1	0.2	0.3	0.2	0.2	0.6
Tanning	0.1	1.3	3.1	-0.2	-0.4	1.1	1.8	-1.4	1.7	-0.1	1.4	1.0	1.0	0.9
Body mass index (BMI)	0.1	0.4	2.2	0.3	1.5	-0.0	-0.1	0.2	0.5	-0.5	-1.0	-0.3	-0.5	-0.3
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	-0.2	-0.3	-0.6	-0.6	0.2	0.6	-0.6	0.3	-0.0	0.5	0.1
Asthma	0.1	0.3	0.7	0.5	-0.4	0.8	0.7	0.6	-0.0	-0.2	0.7	0.2	0.5	0.6
Length of working week for main job	0.1	0.1	0.5	0.6	-0.2	0.4	0.7	-0.0	0.0	0.6	-0.0	-0.1	-0.4	-0.1
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

MLF2

Models

Trait associations