TWAS hub - MLIP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1360	0.0300	1.6e-11	0.064	0.112	0.114	0.106	0.111	3.3e-08	1.4e-13	1.1e-13	7.1e-13	2.1e-13
2	ROSMAP	Brain Pre-frontal Cortex	0.0814	0.0273	8.4e-05	0.002	0.031	0.011	0.034	0.005	1.8e-01	6.3e-05	1.3e-02	3.1e-05	7.0e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Alcohol intake versus 10 years previously	9.8	14.6	18.8	-4.3	-3.2
Pulse rate, automated reading	8.9	28.7	28.9	5.4	5.3
Frequency of unenthusiasm / disinterest in last 2 weeks	7.0	9.3	9.3	-3.1	-3.1
Exposure to tobacco smoke at home	5.8	6.5	11.2	-3.4	-1.4
Knee pain experienced in last month	5.6	8.7	13.1	-2.1	-3.6
Arm fat mass (right)	4.8	19.8	27.5	-3.5	-5.2
Arm fat percentage (left)	4.7	18.6	25.7	-3.4	-5.1
Arm fat percentage (right)	4.4	17.4	22.7	-3.5	-4.8
Pulse rate	4.4	7.5	9.3	2.4	3.0
Arm fat mass (left)	4.4	18.2	26.1	-3.2	-5.1
Father’s age at death	4.3	5.7	9.2	1.5	3.0
Medication: Paracetamol	4.3	6.7	10.6	-3.3	-1.7
Body mass index (BMI)	4.0	17.2	25.3	-3.0	-5.0
Trunk fat mass	4.0	17.2	24.0	-3.2	-4.9
Mouth/teeth dental problems: Loose teeth	4.0	4.7	7.0	-2.6	-1.6
Ovarian Cancer	3.9	5.2	7.9	-2.8	-1.6
Weight	3.8	18.5	27.5	-3.1	-5.2
Whole body fat mass	3.8	15.9	22.8	-3.0	-4.8
Overall health rating	3.8	8.1	8.7	-3.0	-2.7
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	4.7	-2.1	-2.2
Health satisfaction	3.5	4.6	5.9	-1.8	-2.4
Average weekly red wine intake	3.5	5.1	7.2	2.7	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.5	4.1	5.0	1.8	2.2
Depression (Nagel 2018)	3.4	5.1	6.2	-2.0	-2.5
Trunk fat percentage	3.4	13.7	17.6	-3.1	-4.2
Leg fat mass (left)	3.4	13.4	19.5	-2.7	-4.4
Leg fat mass (right)	3.3	12.9	19.1	-2.6	-4.4
BMI	3.2	18.6	32.0	-2.3	-5.7
Leg fat-free mass (left)	3.2	17.0	26.4	-2.8	-5.1
Leg predicted mass (left)	3.2	17.1	26.4	-2.8	-5.1
Ever depressed for a whole week	3.2	3.9	4.1	1.9	2.0
Waist circumference	3.1	11.4	16.9	-2.4	-4.1
Body fat percentage	3.1	12.3	16.5	-2.8	-4.1
Medication: Ibuprofen	3.1	3.7	4.8	-2.2	-1.6
Leg fat-free mass (right)	3.1	16.6	25.6	-2.7	-5.1
Hip circumference	3.0	13.1	16.9	-3.1	-4.1
Leg predicted mass (right)	3.0	15.9	24.6	-2.7	-5.0
Breast Cancer	2.9	7.0	11.2	-3.4	-1.7
Medication: Co-codamol	2.9	3.3	6.0	-0.8	-2.4
Impedance of leg (left)	2.9	14.2	24.0	2.1	4.9
Hair/balding pattern: Pattern 3	2.9	4.3	5.0	-1.9	-2.2
Exposure to tobacco smoke outside home	2.7	3.6	3.8	-2.0	-1.8
Emphysema/chronic bronchitis	2.7	3.0	3.8	-1.9	-1.5
Age started oral contraceptive pill	2.7	3.4	3.8	1.7	1.9
Heart disease (siblings)	2.7	3.3	6.3	-2.5	-0.6
Medication: Paracetamol	2.6	4.4	6.7	-2.6	-1.4
Mean time to correctly identify matches	2.6	4.9	7.7	2.8	1.4
Frequency of depressed mood in last 2 weeks	2.5	3.5	6.1	-0.9	-2.5
Impedance of leg (right)	2.5	12.2	20.3	2.0	4.5
Medication: Lansoprazole	2.5	2.9	3.8	1.4	1.9
Rheumatoid Arthritis	2.3	3.2	3.8	-1.6	-2.0
Shortness of breath walking on level ground	2.3	2.8	5.4	-0.4	-2.3
Medication: Blood pressure	2.3	4.3	4.9	-2.2	-1.9
Sensitivity / hurt feelings	2.2	3.8	5.4	2.3	-1.5
Frequency of tiredness / lethargy in last 2 weeks	2.2	3.6	5.6	-1.2	-2.4
Basal metabolic rate	2.2	12.3	19.1	-2.4	-4.4
Systolic Blood Pressure	2.1	10.7	10.9	-3.2	-3.3
Systolic blood pressure, automated reading	2.1	6.1	7.5	-2.7	-2.2
Loneliness, isolation	2.1	2.9	3.8	-1.4	-1.9
Illnesses of father: High blood pressure	2.1	2.6	4.2	1.0	2.0
Suffer from ‘nerves’	2.0	3.2	5.2	-1.1	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	2.5	-1.3	-1.6
Verbal and Numeric Reasoning (VNR)	1.9	4.7	6.1	2.5	1.8
Smoking Status	1.9	4.6	5.6	-1.9	-2.4
Average weekly spirits intake	1.9	2.3	2.7	-1.4	-1.7
Depressed Affect (Nagel 2018)	1.8	3.9	7.0	-0.9	-2.6
Age at First Birth	1.8	2.6	3.1	1.8	1.5
Townsend deprivation index at recruitment	1.8	2.5	4.9	-2.2	0.2
Relative age voice broke	1.8	2.7	3.4	1.8	1.4
Mouth/teeth dental problems	1.8	2.8	3.9	2.0	1.3
Birth weight of first child	1.8	3.2	3.4	1.8	1.7
Number of full brothers	1.8	2.2	4.4	-2.1	-0.3
Pain type(s) experienced in last month: Hip pain	1.8	2.3	4.3	-0.6	-2.1
Number of treatments/medications taken	1.6	2.9	3.6	-1.5	-1.9
Severe depression (siblings)	1.6	1.8	3.5	-0.4	1.9
Maternal smoking around birth	1.6	2.3	3.2	-1.8	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	6.7	2.6	1.8
Breastfed as a baby	1.6	1.9	2.1	-1.3	-1.4
Leg fat percentage (right)	1.6	5.6	8.6	-1.6	-2.9
Comparative body size at age 10	1.6	4.5	9.1	0.0	-3.0
Whole body fat-free mass	1.6	8.9	14.7	-1.8	-3.8
Mood swings	1.6	2.9	5.4	-0.6	-2.3
Whole body water mass	1.6	8.9	14.6	-1.8	-3.8
Pack years adult smoking proportion	1.5	2.2	3.5	-1.9	-1.0
Medication: Atenolol	1.5	1.9	3.6	-0.5	-1.9
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.0	1.4	1.3
Leg pain on walking	1.5	1.9	2.9	1.0	-1.7
Arm fat-free mass (left)	1.5	7.4	11.1	-1.9	-3.3
Neuroticism (2016)	1.4	2.0	3.1	-1.0	-1.7
Fluid intelligence score	1.4	2.9	3.4	1.8	1.6
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.9	-1.7	-0.8
Forced vital capacity (FVC), Best measure	1.4	5.3	6.6	2.6	2.0
Medication: Allopurinol	1.4	1.9	2.8	1.0	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.2	-1.8	-0.4
Hypertension (Self-reported)	1.4	3.8	4.5	-2.1	-1.8
Friendships satisfaction	1.4	1.8	2.9	-0.8	-1.7
Leg fat percentage (left)	1.4	5.1	7.9	-1.5	-2.8
Pain experienced in last month	1.4	2.4	3.4	1.2	1.8
Arm predicted mass (left)	1.4	7.0	10.4	-1.9	-3.2
LDL Cholesterol	1.3	2.1	3.3	0.9	1.8
Medication: Metformin	1.3	1.8	3.1	-0.7	-1.8
Diabetes (father)	1.3	1.6	3.0	-1.7	0.4
Stomach or abdominal pain in last month	1.3	1.6	2.3	-1.5	-1.0
High blood pressure (mother)	1.3	1.8	1.9	-1.4	-1.4
Alcohol usually taken with meals	1.3	2.1	4.2	2.0	0.2
Hearing difficulty/problems with background noise	1.3	2.1	2.7	1.6	1.2
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.7	-0.4	1.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.3	-1.1	-1.5
Impedance of whole body	1.3	6.7	12.5	1.0	3.5
Intelligence (Savage-Jansen 2018)	1.2	3.7	6.3	2.5	1.0
Multivitamins +/- minerals	1.2	1.5	2.1	-1.4	-1.0
Noisy workplace	1.2	1.5	2.4	-0.7	-1.6
Arm fat-free mass (right)	1.2	6.2	10.4	-1.4	-3.2
Arm predicted mass (right)	1.2	6.3	10.5	-1.5	-3.2
Smoking status: Previous	1.2	1.8	3.4	-1.9	-0.4
Medication: Lisinopril	1.2	1.6	1.8	-1.3	-1.2
Fractured/broken bones in last 5 years	1.2	1.6	2.4	-0.9	-1.5
Alzheimer’s Disease (in father)	1.1	1.1	1.8	-0.7	-1.4
Ever had hysterectomy (womb removed)	1.1	1.2	2.4	-1.5	-0.1
Angina	1.1	1.5	2.8	1.7	-0.3
Average weekly fortified wine intake	1.1	1.3	2.3	0.6	1.5
Fed-up feelings	1.1	2.1	3.5	-0.8	-1.9
High blood pressure	1.1	2.9	4.0	-2.0	-1.4
Depression (self-reported)	1.1	1.3	2.7	-1.6	-0.1
Headache pain in last month	1.1	1.9	3.4	-1.8	-0.6
Wheeze or whistling in the chest in last year	1.1	2.0	3.8	-2.0	-0.3
Angina (self-reported)	1.1	1.4	2.8	1.7	-0.2
Medication: Gliclazide	1.1	1.2	2.2	-0.4	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.4	3.9	2.0	1.0
Ever smoked	1.1	2.0	3.9	-2.0	-0.2
Irritability	1.1	1.8	3.5	-0.3	1.9
Ulcerative Colitis	1.0	1.4	2.3	1.5	-0.7
Blood Eosinophil Count	1.0	7.7	10.6	-2.2	-3.3
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.3	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.5	4.8	2.2	1.5
Worry too long after embarrassment	1.0	1.6	2.4	1.6	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	3.2	-0.9	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	1.6	0.9	1.3
Reaction Time	0.9	1.7	2.3	1.5	1.1
Bipolar Disorder (2011)	0.9	0.9	1.5	1.2	0.5
Type 2 Diabetes (T2D) (2018)	0.9	1.8	2.9	0.8	-1.7
Qualifications: CSEs or equivalent	0.9	1.2	1.5	-0.9	-1.2
Number of incorrect matches in round	0.9	1.5	1.7	1.2	1.3
Forced vital capacity (FVC)	0.9	3.4	4.5	2.1	1.6
Heart attack	0.9	1.1	2.1	1.4	0.4
Trunk fat-free mass	0.9	5.2	8.9	-1.2	-3.0
Happiness	0.9	1.1	1.4	-1.2	-0.9
Qualifications: A levels/AS levels or equivalent	0.9	2.1	3.1	1.8	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	1.1	1.0	1.0
Trunk predicted mass	0.9	5.3	8.9	-1.3	-3.0
Eye problems/disorders: None of the above	0.9	1.1	2.2	0.0	1.5
Medication for pain relief, constipation, heartburn	0.9	1.6	3.2	1.8	0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	0.5	-1.4
Alzheimer’s Disease (in mother)	0.8	1.0	1.2	-0.9	1.1
Alzheimer’s Disease (including proxy)	0.8	1.2	2.3	-1.5	-0.1
Past tobacco smoking	0.8	1.6	3.0	1.7	0.3
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.6	-0.7	1.3
Lung cancer (father)	0.8	0.9	1.0	-0.9	-1.0
Loud music exposure frequency	0.8	0.9	1.2	-1.1	-0.8
Alcohol intake frequency.	0.8	1.9	3.7	-1.9	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.5	-1.2	0.6
Eye problems/disorders: Cataract	0.8	1.0	1.9	-0.3	-1.4
Miserableness	0.8	1.4	1.8	-1.0	-1.3
Pack years of smoking	0.8	1.2	2.0	-1.4	-0.6
Ulcerative Colitis (UC)	0.7	1.2	2.5	1.6	-0.1
Blood White Count	0.7	5.0	5.6	-2.1	-2.4
Lung FVC	0.7	3.7	4.9	2.2	1.6
Chronotype (morning person)	0.7	1.7	3.1	1.8	0.6
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.4	-1.2	-0.5
Current tobacco smoking	0.7	1.2	1.4	-1.0	-1.2
Supplements: Glucosamine	0.7	0.9	1.3	-0.7	-1.1
Hair/balding pattern: Pattern 2	0.7	0.9	1.0	0.9	1.0
Blood clot in the leg (DVT)	0.7	0.8	1.3	-0.7	-1.1
Medication: Amlodipine	0.7	1.0	2.0	-0.0	-1.4
Qualifications: College or University degree	0.7	2.3	3.9	0.9	2.0
Medication: Omeprazole	0.7	0.8	1.0	1.0	0.8
Number of full sisters	0.7	0.9	1.3	0.7	1.1
Age at last live birth	0.7	1.1	2.1	0.0	1.4
Ever had bowel cancer screening	0.7	0.8	1.0	-0.9	1.0
Back pain experienced in last month	0.7	1.0	2.0	-0.1	-1.4
Breast cancer (self-reported)	0.7	0.8	1.6	0.2	-1.3
Financial situation satisfaction	0.7	0.9	1.7	-0.2	-1.3
Average weekly beer plus cider intake	0.7	1.0	1.8	-1.4	0.4
Supplements: Calcium	0.7	0.7	1.1	-0.6	-1.1
Alcohol drinker status: Previous	0.7	0.8	1.3	-0.6	1.1
Neuroticism (Nagel 2018)	0.6	1.5	2.9	-0.0	-1.7
Body Mass Index (BMI) (2010)	0.6	0.8	1.4	-0.5	-1.2
Supplements: Zinc	0.6	0.6	1.2	-1.1	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.4	0.6	1.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	0.9	-0.6	1.0
Financial difficulties in last 2 years	0.6	0.8	1.3	-0.5	-1.1
Pain all over the body in last month	0.6	0.7	1.3	1.2	-0.1
Impedance of arm (right)	0.6	2.6	5.1	0.1	2.3
Pulse wave Arterial Stiffness index	0.6	0.6	0.8	0.7	-0.9
Length of working week for main job	0.6	0.6	0.9	0.9	0.6
Gout (self-reported)	0.6	0.9	1.7	0.3	-1.3
Migraine (self-reported)	0.6	0.8	0.9	0.8	0.9
Chest pain or discomfort	0.6	0.8	1.1	-1.0	-0.8
Family relationship satisfaction	0.6	0.7	1.0	-0.7	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.4	0.2	1.2
Mineral and other dietary supplements	0.6	0.8	1.3	1.2	0.5
High cholesterol (Self-reported)	0.6	1.0	1.5	-0.7	1.2
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.0	1.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.5	1.2	0.3
Schizophrenia (2018)	0.5	1.0	1.6	-1.2	-0.6
Primary Biliary Cirrhosis	0.5	0.8	1.3	-0.5	-1.1
Triglycerides	0.5	0.8	0.9	1.0	0.8
Hearing difficulty/problems: Yes	0.5	0.8	1.0	0.7	1.0
Relative age of first facial hair	0.5	1.1	1.7	0.7	1.3
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	0.7	0.9	0.8
Asthma	0.5	1.0	1.6	-1.3	-0.6
Prospective memory result	0.5	0.6	1.1	1.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.1	0.4	-1.1
Pulse wave peak to peak time	0.5	0.6	0.7	-0.7	0.8
Comparative height size at age 10	0.5	2.8	5.4	-0.4	-2.3
Hearing aid user	0.5	0.6	0.7	0.7	0.8
Mother’s age at death	0.5	0.6	0.7	0.9	0.7
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	1.0	0.2
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.1	1.4	0.9
Cholesterol lowering medication	0.5	0.8	1.0	1.0	0.7
Fasting Glucose	0.4	0.5	0.9	0.2	1.0
Waist Hip Ratio (WHR)	0.4	1.8	3.0	1.7	0.7
Cardiovascular Disease	0.4	1.4	2.1	-1.5	-0.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.6	-0.6	-0.8
Chronic bronchitis/emphysema (father)	0.4	0.5	0.7	0.5	0.8
Had other major operations	0.4	0.5	0.7	0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.7	0.6	0.8
Illnesses of siblings	0.4	0.6	1.1	0.4	-1.0
Falls in the last year	0.4	0.5	0.8	0.5	-0.9
Mouth/teeth dental problems: Dentures	0.4	0.7	1.3	-1.1	-0.2
Pulse wave reflection index	0.4	0.5	1.0	0.3	-1.0
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.7	0.8	-0.4
Medication: Aspirin	0.4	0.6	0.7	-0.9	0.7
Illnesses of father: Heart disease	0.4	0.6	0.7	-0.7	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.1	-1.1	0.5
Asthma (self-reported)	0.4	0.8	1.2	-1.1	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.8	0.4
Crohns Disease (2017)	0.3	0.7	0.8	-0.9	-0.8
Irritable Bowel Disease (IBD)	0.3	0.7	1.0	0.6	-1.0
HbA1C	0.3	0.4	0.4	0.6	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.4	0.6	-0.6
Allergy or Eczema	0.3	0.8	1.5	-1.2	-0.2
Respiratory disease	0.3	0.6	0.8	-0.9	-0.7
Vitamin and mineral supplements	0.3	0.4	0.8	-0.1	0.9
Diabetes (mother)	0.3	0.4	0.5	-0.5	0.7
Age when periods started (menarche)	0.3	0.8	1.0	-1.0	0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.6	-0.8	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.7	0.0	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.4	0.4	1.2
Allergy	0.3	0.7	1.4	1.2	0.1
Illnesses of mother	0.3	0.4	0.6	0.8	-0.4
Impedance of arm (left)	0.3	1.6	3.0	0.4	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.8	-0.9	0.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.8	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	-0.9	-0.3
Birth weight	0.3	0.7	1.3	-1.1	0.3
High blood pressure (siblings)	0.3	0.5	0.9	-0.0	1.0
Heart disease (mother)	0.3	0.4	0.6	0.4	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.4	0.6	0.5
Diabetes diagnosed by doctor	0.3	0.5	0.9	0.4	-1.0
Smoking status: Current	0.3	0.5	0.6	-0.7	-0.8
Number of self-reported non-cancer illnesses	0.3	0.5	0.6	-0.8	-0.5
Wears glasses or contact lenses	0.3	0.3	0.3	0.6	-0.5
Commuting to job workplace: Public transport	0.3	0.4	0.8	-0.9	-0.1
Medication: Atorvastatin	0.3	0.3	0.6	-0.0	-0.8
Risk taking	0.3	0.5	0.9	-1.0	0.0
Unable to work because of sickness or disability	0.3	0.4	0.7	0.3	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.6	0.8	-0.9	-0.6
Worry (Nagel 2018)	0.2	0.4	0.6	-0.4	-0.8
Crohns Disease (2012)	0.2	0.3	0.6	0.2	0.8
HDL Cholesterol	0.2	0.4	0.6	-0.8	0.4
Lupus	0.2	0.2	0.5	-0.7	0.0
Schizophrenia (2014)	0.2	0.5	0.7	-0.8	-0.6
Heel T-Score	0.2	1.4	1.8	-1.4	-1.0
Lung FEV1/FVC ratio	0.2	0.9	1.8	1.3	-0.1
Taking other prescription medications	0.2	0.3	0.6	0.2	-0.8
Serious illness, injury or assault to yourself	0.2	0.2	0.3	-0.5	-0.4
Medication: Levothyroxine sodium	0.2	0.4	0.4	-0.5	-0.7
Sitting height	0.2	1.7	2.7	-0.8	-1.6
Qualifications: None of the above	0.2	0.3	0.5	0.7	-0.4
Medication: Simvastatin	0.2	0.3	0.7	0.0	0.8
Neuroticism score	0.2	0.4	0.8	-0.2	-0.9
Worrier / anxious feelings	0.2	0.3	0.6	0.2	-0.8
Tense / ‘highly strung’	0.2	0.3	0.4	-0.5	-0.6
Hair/balding pattern: Pattern 4	0.2	0.5	0.7	0.8	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.4	-0.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.2	0.4	0.6	-0.4
Age at first live birth	0.2	0.4	0.8	0.0	0.9
Neck or shoulder pain in last month	0.2	0.3	0.5	0.7	0.0
Medication: Blood pressure	0.2	0.4	0.7	-0.3	-0.8
Had major operations	0.2	0.3	0.6	0.7	0.2
Qualifications: nursing, teaching	0.2	0.3	0.4	0.6	0.5
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.6	-0.3
Medication for cholesterol	0.2	0.3	0.6	0.1	0.8
Average weekly champagne plus white wine intake	0.2	0.3	0.6	0.8	0.0
Guilty feelings	0.2	0.3	0.5	0.1	-0.7
Ever taken oral contraceptive pill	0.2	0.2	0.4	-0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.3	-0.6	-0.5
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.3	0.6
Diastolic blood pressure, automated reading	0.2	0.6	0.8	-0.7	-0.9
Major Depression (MDD)	0.1	0.1	0.2	-0.3	-0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.1	0.1	0.3
Hypothyroidism (self reported)	0.1	0.2	0.3	0.5	0.4
Neuroticism	0.1	0.2	0.2	-0.4	-0.4
Medication for hormone replacement therapy	0.1	0.2	0.3	0.5	-0.2
Nervous feelings	0.1	0.2	0.4	0.2	0.6
Had menopause	0.1	0.1	0.2	0.5	0.0
Diabetes (self-reported)	0.1	0.2	0.3	0.3	-0.6
Time employed in main current job	0.1	0.1	0.2	-0.4	-0.2
Number of live births	0.1	0.1	0.2	-0.2	-0.4
Medication: Cholesterol lowering	0.1	0.2	0.4	-0.1	0.6
Standing height	0.1	0.7	1.3	-0.4	-1.1
Peak expiratory flow (PEF)	0.1	0.2	0.2	0.5	-0.5
Glaucoma (self-reported)	0.1	0.1	0.1	0.3	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	-0.3	-0.2
Supplements: Vitamin C	0.1	0.1	0.2	0.4	-0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.2	-0.4	0.2
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.4	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.3	-0.3
Medication: Aspirin	0.1	0.2	0.2	-0.5	0.3
Medication: Bendroflumethiazide	0.1	0.1	0.3	-0.5	0.1
Alcohol drinker status: Never	0.1	0.1	0.2	0.2	0.4
Number of operations (self-reported)	0.1	0.1	0.2	-0.1	-0.5
Myopia	0.1	0.1	0.1	0.4	0.4
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.5	0.1
Bipolar Disorder (2018)	0.0	0.0	0.1	0.2	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.1	0.1	0.1	0.3
Blood Platelet Count	0.0	0.4	0.5	-0.5	0.7
Blood Red Count	0.0	0.3	0.6	-0.8	0.0
Height	0.0	0.6	1.1	-0.3	-1.1
Hair Pigment	0.0	0.8	1.5	-0.2	-1.2
Tanning	0.0	0.0	0.0	-0.0	0.1
Hand grip strength (left)	0.0	0.0	0.0	-0.1	0.1
Hand grip strength (right)	0.0	0.1	0.3	0.0	0.5
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	-0.3	0.1
Medication: Ramipril	0.0	0.0	0.1	0.0	-0.2
Number of children fathered	0.0	0.0	0.0	0.1	0.2
Medication: Seretide 50 evohaler	0.0	0.0	0.0	-0.2	-0.2
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.1	-0.1
Commuting to job workplace: Cycle	0.0	0.0	0.1	-0.3	-0.1

Hub : Genes

MLIP

Models

Trait associations