TWAS hub - MN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.140	0.0477	0.00330	-0.002	NA	-0.002	NA	0.001	0.45	NA	0.4800	NA	0.26
2	TCGA	Testicular Germ Cell Tumors	0.354	0.0980	0.00089	-0.005	0.051	0.068	NA	0.015	0.53	0.0067	0.0021	NA	0.09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Heart disease (siblings)	5.4	6.7	9.8	3.1	-1.9
Alzheimer’s Disease (in mother)	4.8	5.7	10.8	0.7	3.3
Diastolic blood pressure, automated reading	4.6	14.4	26.8	-5.2	-1.4
Medication for hormone replacement therapy	4.4	4.9	9.8	-3.1	-0.2
Forced expiratory volume in 1-second (FEV1)	4.2	14.2	28.3	5.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	3.8	7.9	15.7	4.0	0.4
Medication: Atorvastatin	3.8	4.7	8.9	3.0	-0.6
Falls in the last year	3.7	5.0	6.3	2.5	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.7	11.7	23.3	4.8	0.0
Supplements: Zinc	3.6	3.9	7.3	-2.7	0.7
Stomach or abdominal pain in last month	3.5	4.4	8.2	-0.8	2.9
Ulcerative Colitis (UC)	3.4	6.5	11.0	-1.4	3.3
Forced vital capacity (FVC), Best measure	3.4	12.6	25.0	5.0	0.4
Alzheimer’s Disease (including proxy)	3.2	4.6	9.2	0.2	3.0
Crohns Disease (2012)	3.2	5.1	6.6	-2.6	-1.9
Forced vital capacity (FVC)	3.0	11.6	22.8	4.8	0.6
Number of children fathered	3.0	3.4	6.1	2.5	0.8
Had other major operations	2.9	3.5	4.6	-2.1	-1.6
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.6	2.4	0.6
Financial difficulties in last 2 years	2.8	3.7	5.8	-1.3	2.4
Maternal smoking around birth	2.6	3.7	6.8	2.6	0.8
Number of full sisters	2.6	3.2	6.4	2.5	-0.0
Ever depressed for a whole week	2.6	3.2	6.1	2.5	0.5
Hand grip strength (right)	2.5	6.8	11.3	3.4	1.6
Mouth/teeth dental problems: Loose teeth	2.5	3.0	5.6	0.7	2.4
Illnesses of father: High blood pressure	2.5	3.2	3.9	-1.6	-2.0
Age started oral contraceptive pill	2.4	3.0	6.0	0.1	2.5
Angina	2.3	3.0	4.9	2.2	1.0
Had major operations	2.3	2.6	3.0	1.7	1.5
Standing height	2.2	21.9	43.8	6.6	0.0
Back pain experienced in last month	2.2	3.2	4.1	2.0	1.5
Hand grip strength (left)	2.1	5.4	9.0	3.0	1.3
Serious illness, injury or assault to yourself	2.1	2.6	4.7	2.2	0.7
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.4	3.2	-1.8	1.3
Health satisfaction	2.1	2.7	3.3	1.8	1.4
Medication for cholesterol	2.1	3.1	6.2	2.5	0.3
Breast cancer (self-reported)	2.1	2.5	4.9	2.2	0.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.1	-1.1	-2.0
LDL Cholesterol	2.0	3.1	4.4	-2.1	1.4
Trunk fat-free mass	2.0	11.5	22.0	4.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	3.4	1.1	-1.8
Tense / ‘highly strung’	2.0	3.3	4.4	-1.5	2.1
Comparative height size at age 10	2.0	10.8	21.6	4.6	-0.0
Crohns Disease (2017)	1.9	4.1	5.7	-1.6	-2.4
Ulcerative Colitis	1.9	2.7	3.8	-1.3	1.9
Height	1.9	36.8	72.1	8.5	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.9	3.0	5.9	0.3	2.4
Prospective memory result	1.9	2.4	4.1	0.8	-2.0
Trunk predicted mass	1.9	10.9	20.9	4.6	0.9
Suffer from ‘nerves’	1.9	3.0	4.9	-1.0	2.2
Friendships satisfaction	1.9	2.3	2.6	-1.4	1.6
Pain experienced in last month	1.9	3.1	4.7	-2.2	-1.2
Comparative body size at age 10	1.8	5.1	9.6	-0.8	3.1
Angina (self-reported)	1.8	2.4	4.0	2.0	0.9
High cholesterol (Self-reported)	1.8	3.2	6.1	0.4	-2.5
Ever had prostate specific antigen (PSA) test	1.8	2.0	3.5	-0.8	1.9
Sitting height	1.7	12.0	23.9	4.9	0.2
Mouth/teeth dental problems	1.7	2.6	4.9	0.6	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	2.9	-1.7	-1.1
Overall health rating	1.7	3.7	7.3	-0.1	2.7
Illnesses of father: Heart disease	1.7	2.4	4.8	2.2	-0.2
Commuting to job workplace: Walk	1.7	1.9	2.5	1.1	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	3.1	1.0	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.5	6.8	2.6	-0.5
Mean Putamen Volume	1.6	1.9	2.1	-1.5	-1.3
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	3.8	-0.5	1.9
Whole body fat-free mass	1.6	9.2	17.5	4.2	0.9
Heart attack	1.5	1.9	3.6	1.9	-0.4
Heart disease (mother)	1.5	1.8	3.4	1.8	0.5
Whole body water mass	1.5	8.8	16.9	4.1	0.8
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.6	1.9	-0.4
Prostate Cancer	1.4	2.0	3.6	1.9	0.7
Medication: Simvastatin	1.4	2.0	3.5	-0.8	-1.9
Blood clot in the leg (DVT)	1.4	1.8	2.9	-0.8	-1.7
Medication: Seretide 50 evohaler	1.4	1.7	1.7	-1.3	1.3
Arm predicted mass (right)	1.4	6.9	13.7	3.7	0.4
Arm predicted mass (left)	1.4	7.0	13.7	3.7	-0.4
Diabetes (mother)	1.3	1.7	3.4	1.8	-0.1
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	2.9	-0.8	-1.7
Peak expiratory flow (PEF)	1.3	3.0	4.3	2.1	-1.3
Arm fat-free mass (right)	1.3	6.9	13.6	3.7	0.4
Basal metabolic rate	1.3	7.2	14.4	3.8	0.3
Arm fat-free mass (left)	1.3	6.8	13.5	3.7	-0.4
Rheumatoid Arthritis	1.2	1.6	2.8	0.7	1.7
Diabetes (father)	1.2	1.4	2.9	1.7	0.0
Number of incorrect matches in round	1.2	1.9	2.4	1.5	1.2
Hearing difficulty/problems with background noise	1.2	1.9	3.8	-0.0	-1.9
Illnesses of siblings	1.2	1.7	3.2	-1.8	0.6
Glaucoma (self-reported)	1.2	1.4	1.9	1.0	-1.4
Leg predicted mass (right)	1.2	6.3	12.1	3.5	0.7
Irritable Bowel Disease (IBD)	1.1	2.6	4.3	-2.1	1.0
Lung FEV1/FVC ratio	1.1	5.7	9.1	3.0	-1.6
Severe depression (siblings)	1.1	1.3	1.7	0.9	1.3
Hair/balding pattern: Pattern 2	1.1	1.4	1.6	1.1	1.3
Hair/balding pattern: Pattern 3	1.1	1.6	3.2	0.2	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.9	0.7	1.7
Medication: Paracetamol	1.1	1.8	3.2	1.8	0.6
Leg pain on walking	1.1	1.3	2.6	1.6	0.4
Leg fat-free mass (right)	1.1	5.9	11.4	3.4	0.6
Supplements: Calcium	1.1	1.2	2.3	-1.5	-0.4
Frequency of depressed mood in last 2 weeks	1.0	1.4	2.8	0.0	1.7
Townsend deprivation index at recruitment	1.0	1.4	2.8	0.2	1.7
Hayfever, allergic rhinitis or eczema	1.0	2.1	4.0	-0.5	-2.0
Lung cancer (father)	1.0	1.2	2.0	-1.4	-0.6
Pulse wave Arterial Stiffness index	1.0	1.1	1.9	-0.6	1.4
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.0	1.4	0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.6	-1.6	0.1
Shortness of breath walking on level ground	1.0	1.2	2.0	1.4	0.7
Knee pain experienced in last month	1.0	1.6	2.6	1.6	0.7
Average weekly red wine intake	1.0	1.5	3.0	-0.0	-1.7
Guilty feelings	1.0	1.5	2.8	0.4	1.7
Reaction Time	0.9	1.7	2.4	-1.0	1.5
Age at First Birth	0.9	1.3	2.5	1.6	0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	1.7	0.8	-1.3
Medication: Co-codamol	0.9	1.0	2.0	-0.0	-1.4
Leg fat-free mass (left)	0.9	4.5	8.7	2.9	0.6
Leg predicted mass (left)	0.9	4.7	9.1	3.0	0.5
Nervous feelings	0.9	1.8	2.8	0.9	1.7
Qualifications: None of the above	0.9	2.0	3.7	1.9	0.4
Fluid intelligence score	0.9	2.0	3.0	-0.9	-1.7
Pulse wave reflection index	0.9	1.1	1.9	-0.5	-1.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.8	-1.7	0.3
Number of full brothers	0.9	1.2	2.1	-0.5	1.5
Pulse wave peak to peak time	0.9	1.1	1.5	0.8	-1.2
Medication: Lisinopril	0.9	1.1	2.1	-0.4	-1.4
Basal cell carcinoma (self-reported)	0.9	1.1	1.3	0.9	1.1
Allergy or Eczema	0.8	2.1	3.7	-0.7	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	2.9	1.7	0.8
High blood pressure	0.8	2.2	3.9	-2.0	-0.7
Medication: Levothyroxine sodium	0.8	1.3	2.6	1.6	-0.3
Chronic bronchitis/emphysema (father)	0.8	0.9	1.5	-1.2	0.6
Allergy	0.8	1.9	2.6	1.1	1.6
Weight	0.8	4.1	7.8	2.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.3	0.6	1.5
Mouth/teeth dental problems: Dentures	0.8	1.3	2.6	0.1	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.0	0.0	1.4
Depression (self-reported)	0.8	1.0	1.9	0.4	1.4
Illnesses of mother	0.8	0.9	1.9	-1.4	-0.1
Exposure to tobacco smoke at home	0.8	1.0	1.6	1.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.1	1.8	-0.2
Qualifications: College or University degree	0.8	2.4	4.8	0.1	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.7	0.4	-1.3
Hypertension (Self-reported)	0.8	2.3	4.2	-2.0	-0.7
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.5	0.7	1.2
Myopia	0.8	1.1	2.2	-0.1	1.5
Depressed Affect (Nagel 2018)	0.7	1.5	2.6	1.6	0.7
Worry (Nagel 2018)	0.7	1.5	2.3	-0.9	1.5
Verbal and Numeric Reasoning (VNR)	0.7	1.6	2.4	-1.6	-0.9
Fasting Glucose	0.7	0.8	1.1	-1.1	-0.8
Waist Hip Ratio (WHR)	0.7	3.0	5.2	-2.3	-0.8
Lung FVC	0.7	3.7	6.3	2.5	1.1
High blood pressure (mother)	0.7	1.0	1.8	-0.3	-1.3
Had menopause	0.7	0.9	1.4	-0.7	-1.2
Migraine (self-reported)	0.7	0.8	1.1	-1.0	-0.8
Mean time to correctly identify matches	0.7	1.4	2.7	-0.4	1.6
Ever had bowel cancer screening	0.7	0.9	1.7	0.0	1.3
Medication: Paracetamol	0.7	1.0	2.0	1.4	-0.2
Unable to work because of sickness or disability	0.7	1.0	1.4	1.2	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.5	-0.5	-1.2
Bipolar Disorder (2018)	0.6	1.0	2.0	-1.4	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	0.8	0.9	-0.8
Heel T-Score	0.6	4.9	7.8	1.4	-2.8
Qualifications: CSEs or equivalent	0.6	0.8	1.4	-0.3	1.2
Happiness	0.6	0.7	1.0	0.7	1.0
Medication: Cholesterol lowering	0.6	1.0	1.3	1.1	-0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.4	-0.5	1.2
Headache pain in last month	0.6	1.0	1.8	1.3	0.6
Leg fat percentage (right)	0.6	2.2	3.9	-0.8	-2.0
Age at first live birth	0.6	1.1	1.7	0.7	-1.3
Medication: Omeprazole	0.6	0.7	1.3	-0.3	-1.1
Pulse rate, automated reading	0.6	1.9	2.8	-1.7	1.0
Mood swings	0.6	1.2	1.9	0.6	1.4
Loneliness, isolation	0.6	0.8	1.3	1.1	0.6
Medication: Blood pressure	0.6	1.1	2.1	-1.4	0.1
Fractured/broken bones in last 5 years	0.6	0.7	1.2	1.1	0.4
Neuroticism	0.5	1.2	2.2	-0.5	1.5
Hearing difficulty/problems: Yes	0.5	0.8	0.9	-0.8	-0.9
Fed-up feelings	0.5	0.9	1.5	0.6	1.2
Supplements: Glucosamine	0.5	0.7	1.3	-1.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.0	0.3	1.0
Medication: Atenolol	0.5	0.6	0.9	-0.5	-1.0
Trunk fat mass	0.5	2.2	2.4	1.5	-1.4
Neuroticism score	0.5	1.0	1.9	-0.4	1.4
Hip circumference	0.5	2.3	3.7	1.9	-0.9
Pulse rate	0.5	0.8	1.4	-1.2	0.4
Loud music exposure frequency	0.5	0.6	0.9	-0.9	0.5
Worry too long after embarrassment	0.5	0.9	1.0	-1.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.1	-0.3	1.1
Smoking status: Previous	0.5	0.8	1.5	1.2	-0.1
Eye problems/disorders: Cataract	0.5	0.6	0.6	0.8	0.8
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	-0.4	-1.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.3	1.0
Alcohol drinker status: Never	0.5	0.6	0.9	0.9	-0.6
Leg fat percentage (left)	0.5	1.7	3.4	-0.2	-1.9
Cholesterol lowering medication	0.5	0.8	1.4	-0.4	-1.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.4	-1.6	-0.5
Neuroticism (Nagel 2018)	0.4	1.0	2.0	0.1	1.4
HbA1C	0.4	0.4	0.7	0.8	0.4
Sensitivity / hurt feelings	0.4	0.7	1.1	1.0	0.5
Impedance of leg (right)	0.4	2.2	3.2	-1.1	-1.8
Trunk fat percentage	0.4	1.7	3.2	0.4	-1.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.2	-1.0
Multivitamins +/- minerals	0.4	0.5	1.0	1.0	-0.0
Impedance of leg (left)	0.4	2.1	3.9	-0.5	-2.0
Asthma	0.4	0.9	1.5	-1.2	0.5
Gout (self-reported)	0.4	0.5	0.6	0.8	0.6
Birth weight	0.4	0.9	1.6	1.2	-0.5
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.7	-0.3	0.9
Body fat percentage	0.4	1.8	3.5	0.2	-1.9
Neck or shoulder pain in last month	0.4	0.6	1.1	1.1	0.3
Medication: Blood pressure	0.4	0.8	1.1	-0.6	-1.1
Whole body fat mass	0.4	1.5	1.5	1.2	-1.2
Alcohol intake frequency.	0.4	0.8	1.3	0.6	-1.1
Qualifications: nursing, teaching	0.4	0.7	0.7	-0.8	0.9
Medication: Gliclazide	0.4	0.4	0.6	0.8	0.5
Miserableness	0.4	0.6	0.8	0.9	0.7
Financial situation satisfaction	0.4	0.5	0.8	0.9	0.5
Commuting to job workplace: Public transport	0.4	0.4	0.6	-0.5	0.8
Risk taking	0.4	0.6	1.0	-1.0	0.5
Depression (Nagel 2018)	0.3	0.4	0.9	0.9	0.0
Schizophrenia (2018)	0.3	0.6	1.1	0.3	1.0
BMI	0.3	1.5	2.7	-0.5	-1.7
Systolic Blood Pressure	0.3	1.7	2.8	-0.8	-1.7
Cardiovascular Disease	0.3	1.0	1.6	-0.6	-1.3
Hypothyroidism (self reported)	0.3	0.8	1.5	1.2	-0.3
Respiratory disease	0.3	0.7	1.2	-1.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.7	-0.2	0.8
Medication: Metformin	0.3	0.5	0.8	0.9	0.4
Taking other prescription medications	0.3	0.4	0.6	0.6	0.8
Waist circumference	0.3	1.0	1.9	0.4	-1.4
Past tobacco smoking	0.3	0.6	1.2	-1.1	0.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.5	0.7	-0.6
Pain all over the body in last month	0.3	0.4	0.7	-0.9	-0.1
Arm fat percentage (right)	0.3	1.0	1.9	-0.4	-1.4
Noisy workplace	0.3	0.4	0.8	0.9	-0.1
Birth weight of first child	0.3	0.5	0.6	0.6	0.8
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.5	0.8
Chest pain or discomfort	0.3	0.5	0.5	0.7	0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.8	-0.4
Long-standing illness, disability or infirmity	0.3	0.4	0.7	-0.2	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	-0.8	0.3
Ever smoked	0.3	0.5	1.0	1.0	-0.2
Average weekly beer plus cider intake	0.3	0.4	0.7	0.8	-0.2
Commuting to job workplace: Cycle	0.3	0.3	0.5	-0.7	-0.4
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.7	1.3	0.2
Impedance of whole body	0.3	1.5	2.3	-0.8	-1.5
Breast Cancer	0.2	0.5	0.9	1.0	0.0
HDL Cholesterol	0.2	0.3	0.6	0.8	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.2	0.8
Number of treatments/medications taken	0.2	0.3	0.7	0.8	-0.0
Average weekly spirits intake	0.2	0.3	0.3	0.6	0.5
Ever had hysterectomy (womb removed)	0.2	0.2	0.2	0.5	-0.4
Systolic blood pressure, automated reading	0.2	0.5	0.9	-0.3	-1.0
Current tobacco smoking	0.2	0.4	0.6	0.4	0.8
Average weekly fortified wine intake	0.2	0.2	0.2	-0.4	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.4	0.4	0.6
Age when periods started (menarche)	0.2	0.6	1.0	-1.0	0.5
Alcohol usually taken with meals	0.2	0.4	0.6	-0.8	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.8	0.9	-0.1
Father’s age at death	0.2	0.3	0.3	0.5	-0.5
Number of live births	0.2	0.3	0.4	0.6	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.5	-0.5	0.7
Arm fat mass (right)	0.2	0.6	0.7	0.8	-0.8
Breastfed as a baby	0.2	0.2	0.5	-0.0	0.7
Eye problems/disorders: None of the above	0.2	0.3	0.3	0.5	0.5
Emphysema/chronic bronchitis	0.2	0.3	0.4	-0.6	0.3
Medication: Ibuprofen	0.2	0.3	0.6	-0.1	0.8
Leg fat mass (right)	0.2	0.8	1.5	0.4	-1.2
Age at last live birth	0.2	0.3	0.4	0.4	0.7
Illnesses of siblings: Diabetes	0.2	0.3	0.4	0.7	-0.4
Arm fat percentage (left)	0.2	0.7	1.1	-0.6	-1.0
Diabetes diagnosed by doctor	0.2	0.4	0.4	0.6	0.7
Asthma (self-reported)	0.2	0.5	0.7	-0.9	0.5
Osteoporosis (self-reported)	0.2	0.3	0.5	-0.7	0.3
Smoking status: Current	0.2	0.4	0.6	0.3	0.8
Arm fat mass (left)	0.2	0.6	0.7	0.7	-0.9
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	0.9	0.0
Hearing aid user	0.2	0.3	0.5	-0.7	0.2
Number of operations (self-reported)	0.2	0.4	0.5	0.5	-0.7
Pack years of smoking	0.2	0.3	0.3	0.6	0.5
Leg fat mass (left)	0.2	0.9	1.5	0.6	-1.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.7	0.0
Ovarian Cancer	0.1	0.1	0.1	0.3	0.3
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	0.0
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.5	0.0
Lupus	0.1	0.1	0.2	-0.2	-0.4
Triglycerides	0.1	0.1	0.1	-0.3	-0.3
Blood Eosinophil Count	0.1	0.9	1.4	-0.6	-1.2
Blood Platelet Count	0.1	0.8	0.8	0.9	0.9
Blood White Count	0.1	0.7	1.3	0.1	1.2
Smoking Status	0.1	0.2	0.3	0.2	0.6
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.2	0.4	0.3
Tanning	0.1	1.8	3.2	0.6	1.8
Relative age of first facial hair	0.1	0.2	0.4	-0.6	0.2
Relative age voice broke	0.1	0.2	0.3	0.6	0.1
Medication: Ramipril	0.1	0.2	0.3	-0.0	0.6
Impedance of arm (right)	0.1	0.6	0.9	-0.6	-0.9
Time employed in main current job	0.1	0.2	0.2	-0.3	0.5
Alcohol intake versus 10 years previously	0.1	0.2	0.3	-0.3	-0.6
Worrier / anxious feelings	0.1	0.3	0.3	-0.5	0.5
Medication: Lansoprazole	0.1	0.1	0.2	0.1	-0.5
Impedance of arm (left)	0.1	0.6	1.0	-1.0	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.2	-0.3	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.2	-0.4	0.4
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.2	-0.6
Medication: Allopurinol	0.1	0.1	0.2	0.4	-0.2
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.1	0.4	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.5	0.2
Medication: Aspirin	0.1	0.1	0.2	0.5	0.1
Supplements: Vitamin C	0.1	0.1	0.2	-0.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.5	0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.5	-0.2
Mineral and other dietary supplements	0.1	0.1	0.2	0.5	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.5	-0.1
Medication: Aspirin	0.1	0.1	0.2	0.4	-0.2
Average weekly champagne plus white wine intake	0.1	0.2	0.4	-0.1	-0.6
Wears glasses or contact lenses	0.1	0.1	0.1	-0.3	0.3
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.1	-0.4
Mother’s age at death	0.1	0.1	0.1	0.4	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.3	-0.6	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.2	0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.3	0.0
Alzheimer’s Disease (in father)	0.0	0.0	0.0	-0.1	-0.0
Major Depression (MDD)	0.0	0.0	0.1	0.2	0.0
Neuroticism (2016)	0.0	0.1	0.1	0.1	-0.4
Schizophrenia (2014)	0.0	0.0	0.0	-0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.3	-0.0
Blood Red Count	0.0	0.0	0.1	-0.3	0.0
Chronotype (morning person)	0.0	0.0	0.1	0.1	0.2
Hair Pigment	0.0	0.2	0.3	-0.6	0.3
Vitamin and mineral supplements	0.0	0.0	0.1	0.3	0.1
Pack years adult smoking proportion	0.0	0.0	0.0	-0.1	0.0
Body mass index (BMI)	0.0	0.1	0.2	-0.1	-0.5
Diabetes (self-reported)	0.0	0.0	0.0	0.1	0.1
Length of working week for main job	0.0	0.0	0.1	0.3	-0.1
Medication: Amlodipine	0.0	0.0	0.0	-0.0	0.1
High blood pressure (siblings)	0.0	0.0	0.0	-0.1	-0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.2	0.1
Family relationship satisfaction	0.0	0.0	0.0	-0.2	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.0	0.2	-0.0
Irritability	0.0	0.0	0.1	-0.2	0.2

Hub : Genes

MN1

Models

Trait associations