Hub : Genes

MOBP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1167	0.0340	2.0e-07	0.038	0.052	0.028	0.05	0.034	1.2e-05	2.7e-07	0.00014	4.2e-07	2.6e-05
2	TCGA	Breast Invasive Carcinoma	0.0172	0.0104	2.9e-03	0.004	0.006	0.002	NA	0.003	5.1e-02	1.9e-02	0.12000	NA	7.2e-02
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0313	0.0194	7.2e-03	0.001	0.016	0.000	NA	-0.001	2.4e-01	5.3e-03	0.29000	NA	4.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.3	2.0	4.7	-0.8	2.2	0.8
Bipolar Disorder or Schizophrenia	0.3	0.8	2.0	-0.0	1.4	0.6
Depressed Affect (Nagel 2018)	0.7	1.4	3.4	-0.7	-1.9	-0.5
Depression (Nagel 2018)	0.8	1.2	2.6	-1.6	0.1	1.0
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.0	-1.3	0.0	-1.4
Neuroticism (Nagel 2018)	0.2	0.4	1.0	-0.3	-1.0	-0.2
Schizophrenia (2018)	0.1	0.1	0.4	0.6	0.0	0.1
Schizophrenia vs Biploar Disorder	1.6	2.1	4.7	2.2	-1.1	-0.5
Worry (Nagel 2018)	0.2	0.4	0.7	-0.4	-0.8	-0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.6	0.4	-0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.5	0.1	-0.4
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	-0.4	0.5	0.1
Crohns Disease (2017)	0.1	0.3	0.3	-0.4	0.6	-0.6
Irritable Bowel Disease (IBD)	0.4	1.0	2.0	-1.4	-0.3	-0.8
Ulcerative Colitis (UC)	0.9	1.6	3.2	-1.8	-0.9	-0.9
Major Depression (MDD)	1.4	1.7	3.2	0.5	-1.8	-1.3
Reaction Time	1.0	1.8	5.1	2.3	-0.6	-0.2
Verbal and Numeric Reasoning (VNR)	1.1	2.5	4.6	-2.1	-0.6	-1.7
Breast Cancer	0.3	0.8	1.5	-0.2	-1.0	-1.2
Ovarian Cancer	0.4	0.5	1.3	-1.1	-0.4	0.4
Prostate Cancer	1.6	2.3	4.6	-0.5	-1.4	-2.1
Age at First Birth	0.1	0.1	0.1	0.4	0.2	-0.4
Bipolar Disorder (2011)	0.6	0.6	1.3	0.2	1.1	0.6
Body Mass Index (BMI) (2010)	2.1	2.9	3.8	-1.3	2.0	1.8
Coronary Artery Disease (CAD)	0.2	0.3	0.6	-0.5	-0.8	-0.2
Crohns Disease (2012)	0.7	1.1	3.0	-1.7	0.5	-0.1
Mean Putamen Volume	2.2	2.6	5.9	2.4	0.5	1.2
Fasting Glucose	0.2	0.2	0.3	0.6	-0.0	-0.6
HbA1C	2.3	2.6	4.1	1.8	-2.0	-0.7
HDL Cholesterol	0.0	0.1	0.1	0.3	-0.2	-0.3
LDL Cholesterol	2.5	4.0	7.2	-0.4	2.1	2.7
Lupus	2.7	4.1	6.0	-2.4	-2.3	-1.0
Neuroticism (2016)	0.4	0.6	1.4	-0.4	-0.5	-1.2
Primary Biliary Cirrhosis	2.1	3.0	7.5	-0.4	2.7	1.2
Rheumatoid Arthritis	0.4	0.5	0.7	-0.7	-0.6	-0.8
Schizophrenia (2014)	0.0	0.0	0.1	-0.2	0.2	-0.3
Triglycerides	1.2	1.9	3.6	-1.9	1.5	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	-0.8	0.3	0.4
Ulcerative Colitis	1.3	1.9	3.3	-1.3	-1.8	-0.8
Blood Eosinophil Count	0.2	1.7	2.5	-0.3	-1.6	-1.6
Blood Platelet Count	1.0	12.1	18.7	-2.6	-3.2	-4.3
Blood Red Count	0.2	1.6	2.1	-1.4	-0.8	-1.5
Blood White Count	1.3	9.8	28.2	-5.3	-0.3	-1.0
Heel T-Score	0.6	4.8	13.1	-3.6	0.9	-0.6
BMI	0.5	2.7	6.5	-2.5	0.8	1.0
Height	0.0	0.3	0.7	-0.8	-0.4	0.1
Waist Hip Ratio (WHR)	1.0	4.5	7.1	-0.7	-2.4	-2.7
Systolic Blood Pressure	0.4	2.1	5.0	-2.2	-1.1	-0.1
Smoking Status	2.6	6.1	9.6	0.0	-3.1	-3.0
Allergy or Eczema	0.7	1.9	5.1	-2.3	0.7	0.1
Cardiovascular Disease	3.9	12.8	34.9	-5.9	-0.8	-1.7
Hypothyroidism (self reported)	0.5	1.2	3.2	-1.8	0.5	-0.3
Respiratory disease	1.3	2.9	8.1	-2.8	0.1	-0.8
Type 2 Diabetes (T2D) (2018)	0.9	1.8	3.6	-1.9	1.3	-0.1
Lung FEV1/FVC ratio	0.0	0.1	0.3	-0.0	0.1	0.5
Lung FVC	0.9	4.7	9.0	3.0	1.1	2.0
Neuroticism	0.5	1.2	2.1	0.1	-1.5	-1.2
Chronotype (morning person)	1.2	2.9	3.3	1.6	1.6	1.8
Hair Pigment	0.0	0.3	0.4	-0.6	-0.6	-0.6
Tanning	0.1	0.6	1.5	-0.1	0.6	1.2
Hand grip strength (left)	0.1	0.3	0.6	0.1	0.5	0.8
Number of treatments/medications taken	3.8	6.8	16.5	-4.1	-0.9	-1.7
Average weekly spirits intake	0.4	0.5	1.1	1.0	0.1	0.8
Sensitivity / hurt feelings	0.6	1.1	2.5	1.6	-0.4	-0.8
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.5	-1.2	-0.1	0.7
Hearing difficulty/problems: Yes	0.3	0.5	1.3	-0.0	-1.1	-0.5
Relative age of first facial hair	0.0	0.1	0.1	0.3	-0.3	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.3	-0.4	0.5	-0.5
Ever used hormone-replacement therapy (HRT)	2.9	3.7	6.5	-0.0	-2.5	-2.1
Ever had hysterectomy (womb removed)	1.6	1.8	3.6	0.5	-1.9	-1.3
Systolic blood pressure, automated reading	0.4	1.1	1.8	-1.2	-1.3	-0.3
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	4.8	-0.5	2.2	1.9
Angina	0.2	0.3	0.5	-0.3	-0.7	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.5	-0.2	-0.1
Vitamin and mineral supplements	0.0	0.0	0.0	0.1	0.1	0.0
Supplements: Zinc	2.2	2.4	3.8	0.5	-2.0	-1.7
Medication: Co-codamol	3.5	4.1	5.9	-1.0	2.4	2.3
Medication: Metformin	1.0	1.5	2.6	-1.6	1.1	-0.8
Diabetes (father)	0.5	0.7	1.5	-1.2	-0.4	-0.6
Diabetes (mother)	3.4	4.3	8.0	-0.7	-2.1	-2.8
Severe depression (siblings)	0.4	0.5	1.2	1.1	-0.4	0.1
Pack years adult smoking proportion	0.8	1.3	1.9	-1.4	-1.4	-0.1
Impedance of leg (right)	1.0	5.0	10.0	-1.6	-1.6	-3.2
Leg fat-free mass (left)	0.3	1.8	3.1	-1.2	0.9	1.7
Trunk fat percentage	1.9	7.5	15.9	-4.0	-1.7	-1.9
Hand grip strength (right)	0.2	0.6	0.9	0.3	1.0	0.8
Townsend deprivation index at recruitment	0.0	0.1	0.1	-0.3	-0.1	-0.3
Current tobacco smoking	5.6	9.1	18.4	0.5	-4.3	-3.0
Average weekly fortified wine intake	0.3	0.3	0.5	-0.6	0.7	-0.4
Maternal smoking around birth	0.6	0.9	2.5	-1.6	-0.2	-0.1
Fed-up feelings	0.1	0.3	0.3	-0.6	-0.5	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.4	-1.2	0.5	1.6
Relative age voice broke	0.3	0.4	1.0	1.0	-0.4	-0.1
Taking other prescription medications	1.6	2.5	3.6	-1.9	-1.4	-1.3
Age when periods started (menarche)	0.1	0.3	0.4	-0.5	-0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	1.9	-0.1	-1.4	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	8.2	-2.9	0.9	-1.1
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	5.6	-2.4	0.7	-0.3
Qualifications: CSEs or equivalent	1.4	1.8	3.7	-0.7	1.9	1.2
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.5	0.1	0.7
High blood pressure	4.0	11.1	25.2	-5.0	-1.5	-2.4
Hayfever, allergic rhinitis or eczema	1.1	2.4	5.5	-2.4	1.1	0.5
Multivitamins +/- minerals	0.9	1.2	3.4	-1.8	0.2	0.3
Stomach or abdominal pain in last month	2.3	2.9	7.0	0.5	1.2	2.6
Supplements: Glucosamine	0.3	0.4	0.6	0.3	-0.6	-0.8
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	3.7	0.9	0.2	1.9
Medication: Atenolol	2.3	2.9	6.4	-2.5	-1.0	-1.1
Medication: Levothyroxine sodium	1.4	2.3	3.5	-1.6	1.9	1.0
Sitting height	0.1	0.5	1.2	-1.1	0.2	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.0	-0.6	-0.9	-1.0
High blood pressure (mother)	1.1	1.6	2.0	-1.1	-1.2	-1.4
Body mass index (BMI)	0.6	2.5	6.6	-2.6	0.5	0.8
Impedance of leg (left)	1.2	5.6	10.2	-1.6	-2.0	-3.2
Leg predicted mass (left)	0.4	1.9	3.1	-1.2	1.1	1.8
Trunk fat mass	1.4	6.0	14.4	-3.8	-1.2	-1.5
Waist circumference	0.8	3.0	8.1	-2.8	-0.6	-0.6
Number of incorrect matches in round	0.3	0.6	1.1	1.1	-0.3	0.7
Past tobacco smoking	0.2	0.4	1.1	1.0	-0.4	0.3
Alcohol usually taken with meals	0.5	0.8	1.4	0.9	1.2	-0.1
Nervous feelings	0.4	0.7	1.3	-0.7	-0.4	-1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	-0.1	0.5	1.0
Hearing difficulty/problems with background noise	3.0	4.9	7.7	-2.8	-1.1	-2.4
Hair/balding pattern: Pattern 2	0.4	0.6	1.2	1.1	-0.4	0.6
Had menopause	0.4	0.4	0.6	-0.3	-0.8	-0.8
Had other major operations	0.2	0.3	0.6	0.0	0.7	0.6
Forced vital capacity (FVC)	0.3	1.1	1.6	1.3	0.3	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	7.2	-2.7	0.4	-1.3
Ever unenthusiastic/disinterested for a whole week	1.4	1.8	3.9	-0.1	-2.0	-1.2
Qualifications: None of the above	0.8	1.8	2.3	-1.4	-1.5	-1.1
Financial difficulties in last 2 years	1.1	1.5	3.2	-0.6	-1.8	-1.0
Mouth/teeth dental problems	0.2	0.3	0.9	0.9	0.2	-0.2
Heart attack	1.3	1.6	3.5	-1.9	1.1	0.4
Allergy	1.0	2.3	5.7	2.4	-1.0	-0.4
Pain all over the body in last month	0.6	0.6	1.5	1.2	-0.2	0.5
Diabetes (self-reported)	1.2	1.9	3.9	-2.0	1.2	-0.6
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	6.8	-2.6	0.8	0.1
Medication: Ramipril	0.3	0.3	0.5	-0.6	-0.7	-0.3
Medication: Simvastatin	0.9	1.4	4.1	-2.0	-0.1	-0.1
Fluid intelligence score	0.5	1.1	2.1	-1.5	0.4	-1.0
Illnesses of siblings	0.6	0.9	1.5	1.2	-0.2	1.1
Neuroticism score	0.7	1.5	3.2	0.7	-1.8	-1.0
Weight	0.5	2.7	7.3	-2.7	0.4	0.7
Impedance of arm (right)	1.0	4.8	7.3	0.3	-2.7	-2.6
Arm fat percentage (right)	0.8	3.0	7.2	-2.7	-1.0	-0.9
Trunk fat-free mass	0.4	2.2	4.4	-0.0	1.5	2.1
Hip circumference	0.8	3.4	9.2	-3.0	0.6	0.8
Time employed in main current job	1.2	1.4	2.7	-0.3	-1.2	-1.6
Alcohol intake versus 10 years previously	0.1	0.2	0.5	-0.7	-0.1	0.3
Father’s age at death	1.6	2.2	3.0	1.1	-1.7	-1.5
Worrier / anxious feelings	0.8	1.5	1.6	1.3	-1.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.2	-0.5	-0.1
Falls in the last year	0.2	0.2	0.6	-0.2	0.3	0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.3	0.1	0.5	-0.1
Number of live births	0.5	0.7	1.5	-0.7	0.4	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.1	1.0	0.9	1.8
Pulse rate	0.7	1.1	1.9	-0.6	-1.0	-1.4
Happiness	0.0	0.0	0.1	-0.1	-0.0	-0.3
Noisy workplace	0.5	0.6	0.9	-0.9	0.5	0.8
Qualifications: A levels/AS levels or equivalent	1.2	2.6	3.4	1.8	1.8	1.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.6	-2.1	1.5	0.2
Mouth/teeth dental problems: Dentures	0.9	1.4	2.5	-1.6	-1.2	-0.7
Asthma	0.9	1.9	5.3	-2.3	0.2	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	0.8	-0.6	0.9	0.9
Medication: Cholesterol lowering	1.8	2.8	8.0	-2.8	-0.5	-0.4
Depression (self-reported)	0.8	1.0	2.4	-1.6	-0.6	-0.4
Medication: Lansoprazole	0.9	1.0	2.9	-1.7	0.3	0.0
Prospective memory result	2.8	3.5	5.7	2.4	0.0	2.2
Lung cancer (father)	4.3	5.1	8.2	-1.4	-2.2	-2.9
Illnesses of mother	2.1	2.6	4.9	0.6	1.6	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	3.6	1.9	0.5	1.9
Pulse wave Arterial Stiffness index	0.8	0.9	1.8	-0.2	-0.9	-1.4
Impedance of arm (left)	0.9	4.1	6.2	-0.0	-2.4	-2.5
Arm fat mass (right)	0.6	2.7	7.8	-2.8	-0.3	-0.1
Trunk predicted mass	0.4	2.1	4.3	-0.0	1.4	2.1
Standing height	0.0	0.1	0.2	-0.5	-0.0	0.3
Length of working week for main job	2.8	3.1	3.6	1.9	-1.7	-1.7
Exposure to tobacco smoke at home	0.8	0.9	1.5	-0.5	1.2	1.0
Breastfed as a baby	1.0	1.3	2.2	1.1	1.5	0.6
Tense / ‘highly strung’	0.4	0.6	1.2	0.0	0.8	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.7	0.2	-1.0	-1.3
Hair/balding pattern: Pattern 4	1.3	3.1	8.5	-2.9	0.6	-0.5
Birth weight of first child	0.1	0.2	0.5	-0.2	0.7	0.1
Peak expiratory flow (PEF)	0.5	1.1	1.2	-1.1	1.1	0.9
Pulse wave reflection index	0.1	0.2	0.3	0.6	-0.2	-0.3
Ever highly irritable/argumentative for 2 days	0.9	1.0	1.9	0.7	-1.4	-0.9
Loud music exposure frequency	1.1	1.2	1.7	1.3	-1.3	-0.5
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	1.8	0.6	1.4	0.9
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.5	-1.6	1.0	0.2
Blood clot in the leg (DVT)	0.2	0.3	0.4	0.6	-0.6	-0.3
Medication: Paracetamol	0.3	0.5	1.1	-1.1	0.5	-0.4
Headache pain in last month	0.5	0.8	1.9	-1.4	0.6	0.1
Medication for cholesterol, blood pressure or diabetes	3.9	6.5	15.2	3.9	1.3	1.6
Glaucoma (self-reported)	3.4	4.0	10.4	-3.2	0.2	-1.2
Gout (self-reported)	1.5	2.1	3.0	-1.3	1.7	1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.9	-1.4	1.3	0.5
Medication: Amlodipine	0.6	0.9	1.0	-1.0	-0.9	-0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	0.0	-0.0	-0.6
Birth weight	1.3	2.8	7.8	2.8	-0.5	-0.5
Chronic bronchitis/emphysema (mother)	3.4	4.0	8.5	0.8	-2.9	-1.7
High blood pressure (siblings)	0.5	0.8	1.1	-1.0	1.1	0.4
Forced vital capacity (FVC), Best measure	0.5	1.9	4.2	2.0	-0.3	1.1
Body fat percentage	1.9	7.6	16.3	-4.0	-1.6	-2.0
Leg fat percentage (right)	2.4	8.6	21.2	-4.6	-1.0	-1.9
Arm fat-free mass (right)	0.9	4.4	5.5	-1.9	2.0	2.4
Exposure to tobacco smoke outside home	0.4	0.5	1.4	-1.2	-0.4	-0.0
Comparative body size at age 10	0.6	1.8	5.3	2.3	-0.0	0.1
Number of full brothers	1.0	1.2	3.2	-1.8	0.4	-0.5
Worry too long after embarrassment	0.5	0.9	1.6	-0.9	-0.6	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.9	3.5	-0.5	-1.9	-1.4
Wheeze or whistling in the chest in last year	3.5	6.3	9.7	-3.1	-1.5	-2.6
Number of children fathered	2.9	3.3	5.4	-0.0	-2.1	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.0	0.0	0.1	0.3	0.1	0.1
Age at first live birth	1.0	1.7	3.2	1.8	1.2	0.7
Pulse wave peak to peak time	0.7	0.8	1.8	-0.1	0.8	1.3
Health satisfaction	0.3	0.4	0.9	-1.0	0.4	0.4
Shortness of breath walking on level ground	0.1	0.1	0.2	0.2	-0.4	0.3
Qualifications: College or University degree	1.4	4.4	7.2	2.7	1.9	1.6
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.0	0.5	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	0.3	0.4	0.3
Emphysema/chronic bronchitis	1.3	1.5	2.0	-1.4	-0.8	-1.4
Medication for pain relief, constipation, heartburn	1.9	3.3	8.6	2.9	0.5	1.0
Neck or shoulder pain in last month	1.3	1.9	4.7	-0.2	-2.2	-0.9
Medication: Blood pressure	4.3	7.7	18.4	-4.3	-0.8	-2.0
Angina (self-reported)	0.2	0.2	0.7	-0.8	-0.2	-0.1
Migraine (self-reported)	3.0	3.7	5.4	-2.3	2.3	0.6
Medication: Ibuprofen	0.1	0.1	0.3	-0.5	0.1	0.0
Medication: Allopurinol	1.9	2.5	3.9	-2.0	1.6	1.1
Medication: Omeprazole	0.5	0.6	1.1	0.4	-1.1	-0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.4	-0.7	-0.3	-0.5
Mean time to correctly identify matches	1.0	2.0	3.2	1.8	-1.3	-1.0
Heart disease (mother)	0.8	0.9	2.7	-1.6	0.3	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.8	-0.2	-1.1
Whole body fat mass	1.4	5.8	14.7	-3.8	-1.0	-1.2
Leg fat mass (right)	1.7	6.5	18.4	-4.3	-0.3	-0.9
Arm predicted mass (right)	0.6	3.0	4.2	-1.5	1.6	2.0
Pulse rate, automated reading	1.0	3.4	5.2	-1.4	-1.7	-2.3
Alcohol intake frequency.	3.8	8.9	13.4	-2.4	-3.7	-2.7
Comparative height size at age 10	0.1	0.6	1.4	0.4	-0.5	-1.2
Number of full sisters	0.4	0.4	1.0	0.2	-0.5	-1.0
Suffer from ‘nerves’	0.2	0.2	0.4	-0.6	-0.3	-0.5
Overall health rating	0.2	0.5	0.8	-0.6	-0.9	-0.5
Chest pain or discomfort	0.5	0.8	1.4	-0.8	0.5	-1.2
Had major operations	3.5	4.1	8.5	-1.8	2.9	0.6
Age at last live birth	1.1	1.5	1.7	1.2	1.2	1.3
Family relationship satisfaction	1.1	1.3	3.9	-2.0	0.1	-0.2
Leg pain on walking	0.2	0.3	0.6	0.3	-0.0	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.5	-0.1	-0.7	-0.4
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.5	-0.2	-1.2	-1.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.6	-0.3	0.0
Medication: Aspirin	3.6	4.7	12.6	-3.5	-0.2	-1.2
Supplements: Vitamin C	2.6	3.1	5.8	2.4	-1.4	-1.2
Knee pain experienced in last month	1.2	1.8	4.9	-2.2	-0.6	0.4
Hypertension (Self-reported)	3.9	10.7	26.7	-5.2	-1.3	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	0.9	-0.9	-0.7	-1.0
Illnesses of father: Heart disease	0.2	0.3	0.5	-0.1	-0.6	-0.7
Illnesses of siblings: Diabetes	0.8	0.9	1.9	-1.4	0.9	0.3
Smoking status: Previous	0.7	1.0	2.0	-1.0	1.4	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	2.5	0.3	1.6	1.5
Whole body fat-free mass	0.4	2.2	4.3	-0.6	1.4	2.1
Leg fat-free mass (right)	0.3	1.8	3.9	-0.8	1.0	2.0
Arm fat percentage (left)	0.8	3.3	8.0	-2.8	-1.0	-0.9
Average weekly red wine intake	2.9	4.3	8.3	2.9	1.4	1.6
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.1	1.1	-0.0	1.0
Mood swings	0.5	0.9	2.3	0.3	-1.5	-0.6
Loneliness, isolation	1.0	1.3	2.5	-1.6	-0.9	-0.8
Long-standing illness, disability or infirmity	2.0	3.1	5.1	-2.3	-1.2	-1.7
Ever had bowel cancer screening	0.9	1.0	1.6	-0.9	-1.3	-0.8
Diabetes diagnosed by doctor	0.7	1.2	1.8	-1.4	1.3	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	-0.4	0.5	0.9
Friendships satisfaction	1.8	2.3	3.7	-1.3	-1.2	-1.9
Qualifications: nursing, teaching	1.2	1.9	5.6	2.4	-0.3	0.0
Commuting to job workplace: Walk	1.5	1.6	4.5	2.1	0.2	0.5
Eye problems/disorders: Cataract	0.5	0.5	1.0	1.0	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.8	-0.2	0.4
Medication for cholesterol	1.2	1.8	3.8	2.0	0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.0	-0.8	-0.2
Back pain experienced in last month	1.0	1.4	3.8	-2.0	-0.1	-0.6
Mineral and other dietary supplements	0.8	1.1	2.0	0.4	1.4	1.1
Breast cancer (self-reported)	2.5	3.0	6.4	-2.5	1.6	-0.1
Asthma (self-reported)	1.1	2.1	5.9	-2.4	-0.0	-0.7
Osteoporosis (self-reported)	5.2	6.5	10.7	2.1	2.1	3.3
Osteoarthritis (self-reported)	0.8	1.0	1.4	-1.1	-0.7	-1.2
Medication: Aspirin	4.4	5.8	13.2	-3.6	-0.7	-1.9
Medication: Gliclazide	1.3	1.5	3.1	0.2	-1.2	-1.8
Illnesses of father: None of the above (group 1)	1.2	1.5	2.9	1.7	0.2	1.3
Smoking status: Current	5.6	8.9	17.4	0.5	-4.2	-3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.7	-0.6	1.6	1.3
Whole body water mass	0.4	2.3	4.6	-0.6	1.4	2.1
Leg predicted mass (right)	0.4	2.0	4.2	-0.8	1.0	2.1
Arm fat mass (left)	0.6	2.5	7.4	-2.7	-0.4	-0.2
Number of self-reported non-cancer illnesses	3.2	5.6	14.0	-3.7	-0.6	-1.5
Average weekly champagne plus white wine intake	0.9	1.3	1.7	0.7	1.3	1.3
Miserableness	1.2	2.0	3.6	-1.3	-1.9	-0.9
Guilty feelings	0.2	0.4	0.8	0.4	0.9	0.4
Wears glasses or contact lenses	0.2	0.2	0.4	-0.2	-0.5	-0.6
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.5	0.1	0.2
Hearing aid user	0.2	0.3	0.6	0.8	-0.1	-0.4
Mother’s age at death	1.0	1.3	2.6	1.6	1.1	0.2
Financial situation satisfaction	0.6	0.8	1.8	-0.4	-0.7	1.3
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.9	2.0	-0.0	-0.2
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.6	-0.2	-0.5
Eye problems/disorders: Glaucoma	2.4	2.8	4.8	-2.2	-0.8	-1.8
Medication: Blood pressure	1.7	3.2	5.4	-2.3	-1.4	-1.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	4.7	-2.2	-0.5	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.5	-0.7	-0.7	-0.3
High cholesterol (Self-reported)	1.4	2.4	6.9	-2.6	-0.6	-0.3
Medication: Bendroflumethiazide	1.6	2.4	6.5	-2.6	0.7	-0.4
Medication: Paracetamol	0.6	1.0	1.8	-1.3	0.3	-1.1
Medication: Lisinopril	2.8	3.6	10.6	-3.2	-0.2	-0.6
Medication: Atorvastatin	1.6	2.0	2.5	-1.4	1.6	1.2
Illnesses of father: High blood pressure	2.4	2.9	7.1	-2.7	0.9	0.9
Alcohol drinker status: Never	0.7	0.8	1.3	-1.1	-1.0	-0.1
Ever smoked	0.3	0.5	0.8	-0.9	-0.3	-0.8
Basal metabolic rate	0.3	1.9	3.0	-1.2	1.1	1.7
Leg fat percentage (left)	2.1	7.8	18.0	-4.2	-1.3	-1.9
Arm fat-free mass (left)	0.5	2.7	3.9	-1.4	1.5	2.0
Number of operations (self-reported)	0.5	0.7	1.1	-1.1	0.8	0.4
Average weekly beer plus cider intake	0.2	0.2	0.6	-0.8	-0.3	0.1
Irritability	0.1	0.1	0.1	0.3	-0.3	-0.3
Risk taking	0.3	0.4	0.7	-0.4	-0.8	-0.5
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.6	1.4	-1.0	-1.6
Fractured/broken bones in last 5 years	1.2	1.6	2.8	0.3	1.4	1.7
Age started oral contraceptive pill	0.3	0.4	1.0	-1.0	0.5	-0.2
Diastolic blood pressure, automated reading	1.1	3.3	4.6	-2.2	-1.7	-1.5
Ever depressed for a whole week	0.2	0.3	0.4	-0.7	-0.6	0.3
Unable to work because of sickness or disability	0.2	0.3	0.4	-0.6	0.5	0.5
Commuting to job workplace: Cycle	0.0	0.1	0.1	0.3	0.3	-0.0
Myopia	0.2	0.2	0.4	0.7	-0.4	-0.2
Vascular/heart problems diagnosed by doctor	4.1	11.3	26.6	5.2	1.4	2.2
Cholesterol lowering medication	0.9	1.3	2.0	-1.0	-0.9	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	1.5	-0.6	-1.2	-1.1
Pain experienced in last month	1.3	2.1	3.1	1.6	1.8	0.8
Supplements: Calcium	0.2	0.2	0.3	0.6	-0.3	-0.4
Basal cell carcinoma (self-reported)	0.5	0.6	1.6	-1.3	0.2	-0.3
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.3	-2.1	1.4	0.7
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.3	-0.4	-0.3
Heart disease (siblings)	2.9	3.6	6.6	-1.0	-1.8	-2.6
Alcohol drinker status: Previous	2.6	2.9	6.5	-0.9	-1.2	-2.5
Pack years of smoking	0.9	1.3	2.4	-1.2	-1.5	-0.1
Impedance of whole body	1.0	5.2	9.2	-1.0	-2.3	-3.0
Leg fat mass (left)	1.5	5.9	16.5	-4.1	-0.6	-1.0
Arm predicted mass (left)	0.6	3.0	4.0	-1.6	1.6	2.0