Hub : Genes

MOCS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1763	0.0681	5.7e-03	0.174	NA	0.152	NA	0.101	7.6e-07	NA	4.2e-06	NA	1.8e-04
2	GTEx	Esophagus Mucosa	0.1400	0.0590	7.1e-03	-0.004	NA	0.020	NA	-0.004	9.0e-01	NA	1.6e-02	NA	6.9e-01
3	ROSMAP	Brain Pre-frontal Cortex	0.0981	0.0307	1.2e-05	0.011	0.029	0.075	0.029	0.064	1.1e-02	1.0e-04	6.4e-10	9.6e-05	1.1e-08
4	TCGA	Colon Adenocarcinoma	0.1110	0.0680	3.3e-03	0.025	0.041	0.012	NA	0.015	1.3e-02	2.1e-03	6.5e-02	NA	4.2e-02
5	TCGA	Thyroid Carcinoma	0.1380	0.0460	6.1e-15	0.108	0.159	0.121	NA	0.155	1.3e-10	2.8e-15	8.0e-12	NA	7.3e-15

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	1.3	-0.1	-1.1	0.3	0.5	0.0
Bipolar Disorder or Schizophrenia	0.3	0.7	1.2	-0.9	-0.9	0.7	-1.1	-0.3
Depressed Affect (Nagel 2018)	0.8	1.8	3.4	1.7	0.0	1.9	1.5	0.6
Depression (Nagel 2018)	1.2	1.9	5.4	1.2	-0.4	2.3	1.5	0.3
Intelligence (Savage-Jansen 2018)	1.5	4.5	11.9	2.7	-0.4	1.4	1.1	3.5
Neuroticism (Nagel 2018)	0.6	1.5	3.2	1.4	-1.8	0.8	1.2	0.1
Schizophrenia (2018)	0.5	1.0	3.1	-1.1	-0.2	0.7	-1.8	-0.3
Schizophrenia vs Biploar Disorder	0.2	0.3	0.8	0.7	-0.2	0.3	-0.0	0.9
Worry (Nagel 2018)	0.7	1.4	5.2	0.6	-2.3	-0.5	0.9	-0.7
Alzheimer’s Disease (in mother)	0.2	0.3	0.8	-0.5	0.9	0.3	0.3	-0.4
Alzheimer’s Disease (in father)	0.1	0.2	0.3	0.2	-0.3	-0.4	0.5	-0.6
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.2	0.4	-0.1	0.6	-0.4
Crohns Disease (2017)	0.2	0.4	1.0	-0.1	1.0	0.5	0.7	-0.3
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	-0.4	0.4	0.3	0.6	-0.4
Ulcerative Colitis (UC)	0.1	0.2	0.3	-0.4	0.4	-0.5	0.4	-0.2
Major Depression (MDD)	0.8	0.9	2.7	-0.3	-1.0	-0.9	0.3	-1.6
Reaction Time	0.3	0.5	0.9	0.6	0.9	0.9	0.7	0.2
Verbal and Numeric Reasoning (VNR)	1.4	3.4	7.2	2.6	-0.6	1.0	1.2	2.7
Breast Cancer	0.9	2.1	4.1	-1.3	-0.7	-1.7	-1.3	-2.0
Ovarian Cancer	2.4	3.1	6.4	-1.5	-0.5	-2.1	-1.4	-2.5
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.9	1.4	2.3	1.5	-1.0	1.3	-0.2	1.3
Bipolar Disorder (2011)	0.6	0.6	1.7	1.1	-0.4	0.4	1.3	-0.1
Body Mass Index (BMI) (2010)	1.1	1.4	4.6	-0.3	1.2	-2.2	0.2	-1.0
Coronary Artery Disease (CAD)	2.8	3.3	5.0	-1.3	-2.2	-2.2	-1.8	-1.4
Crohns Disease (2012)	0.5	0.8	1.1	0.8	0.9	0.8	1.1	0.9
Mean Putamen Volume	3.4	3.9	7.1	2.7	1.2	1.1	1.8	2.5
Fasting Glucose	1.6	1.9	2.9	-1.6	0.1	-1.7	-1.0	-1.7
HbA1C	0.8	0.9	2.7	-0.4	1.1	-1.6	-0.6	0.1
HDL Cholesterol	0.2	0.3	0.8	0.5	-0.5	0.2	0.6	0.9
LDL Cholesterol	0.6	1.0	4.0	0.3	-0.4	-2.0	0.8	-0.3
Lupus	0.5	0.7	2.1	1.5	0.1	0.7	0.9	0.1
Neuroticism (2016)	1.1	1.5	4.9	1.3	-0.9	0.2	2.2	0.4
Primary Biliary Cirrhosis	2.1	2.9	8.7	-0.5	-0.7	-2.9	-0.5	-2.2
Rheumatoid Arthritis	0.2	0.2	0.6	0.2	-0.3	0.1	-0.6	0.8
Schizophrenia (2014)	0.2	0.5	1.9	-0.6	-0.2	0.3	-1.4	0.0
Triglycerides	0.3	0.6	2.1	-0.1	-0.1	-1.4	-0.8	-0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.1	0.4	1.0	0.2	0.6	-0.3
Ulcerative Colitis	0.1	0.2	0.4	-0.5	-0.6	0.0	-0.6	-0.2
Blood Eosinophil Count	0.6	4.3	12.5	-1.7	-0.5	-3.5	-1.0	-2.3
Blood Platelet Count	2.0	23.0	35.9	-5.7	-0.7	-4.8	-4.8	-6.0
Blood Red Count	0.3	2.6	4.6	2.0	0.3	1.5	2.1	1.3
Blood White Count	1.5	11.5	19.8	-4.1	1.1	-3.6	-2.5	-4.5
Heel T-Score	3.1	24.4	37.9	4.7	2.2	5.3	6.2	5.5
BMI	0.7	3.9	6.9	-2.4	1.5	-2.1	-0.7	-2.6
Height	0.1	1.9	3.6	-1.4	0.8	-1.4	-1.9	-1.1
Waist Hip Ratio (WHR)	0.1	0.6	1.0	-0.5	0.8	0.4	-0.9	-1.0
Systolic Blood Pressure	0.3	1.6	2.5	-1.0	1.5	0.0	-1.4	-1.6
Smoking Status	0.3	0.7	1.4	-0.8	0.1	-0.9	-0.7	-1.2
Allergy or Eczema	0.7	1.7	2.9	1.7	-0.0	1.0	1.7	1.4
Cardiovascular Disease	0.2	0.7	1.6	-0.7	0.5	-1.3	-0.8	-0.6
Hypothyroidism (self reported)	0.1	0.3	1.0	0.6	-1.0	0.1	0.1	0.4
Respiratory disease	2.0	4.4	9.7	-2.1	-0.7	-2.5	-1.0	-3.1
Type 2 Diabetes (T2D) (2018)	1.4	2.7	5.2	-2.3	-0.1	-1.4	-1.3	-2.2
Lung FEV1/FVC ratio	0.4	1.8	4.0	0.0	2.0	1.8	-0.5	1.3
Lung FVC	0.4	1.9	6.3	-0.3	-1.5	-0.8	-2.5	0.4
Neuroticism	0.1	0.3	0.8	-0.1	0.2	-0.8	0.5	-0.9
Chronotype (morning person)	1.2	2.7	10.8	0.7	0.8	3.3	0.8	0.9
Hair Pigment	0.0	1.3	2.5	1.2	1.0	0.5	1.2	1.6
Tanning	0.1	1.5	4.0	-2.0	1.3	0.3	-1.0	-0.9
Hand grip strength (left)	0.2	0.5	0.8	0.6	0.9	0.7	0.5	0.9
Number of treatments/medications taken	1.8	3.3	5.6	-1.9	-1.6	-2.0	-0.7	-2.4
Average weekly spirits intake	0.3	0.3	0.9	-0.8	0.1	-1.0	-0.2	-0.4
Sensitivity / hurt feelings	0.6	1.0	3.1	1.0	-1.8	0.0	0.7	0.5
Frequency of depressed mood in last 2 weeks	2.1	2.9	6.7	1.7	-0.8	1.9	2.6	0.8
Hearing difficulty/problems: Yes	1.7	2.5	4.2	2.1	-1.1	0.5	1.9	1.8
Relative age of first facial hair	0.2	0.4	1.0	0.6	-0.6	-1.0	-0.0	0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.1	1.0	-0.9	-0.5	0.2	0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.5	0.7	-0.2	0.2	-0.6
Ever had hysterectomy (womb removed)	0.3	0.3	1.3	0.4	-1.1	0.3	0.1	-0.0
Systolic blood pressure, automated reading	0.4	1.1	5.0	0.0	2.2	0.2	-0.4	-0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.4	-1.5	-0.1	-0.2	0.2	-0.8
Angina	0.5	0.7	1.2	0.6	1.0	0.8	1.1	0.4
Medication for hormone replacement therapy	0.6	0.6	1.1	-0.6	-0.5	-0.7	-1.0	-1.0
Vitamin and mineral supplements	0.1	0.2	0.4	0.2	-0.2	-0.6	0.6	0.0
Supplements: Zinc	1.9	2.0	4.2	1.9	-0.7	1.1	2.0	1.0
Medication: Co-codamol	0.6	0.7	2.7	0.6	-1.6	0.2	-0.0	-0.6
Medication: Metformin	1.1	1.6	4.3	-1.4	-1.0	-0.6	-0.4	-2.1
Diabetes (father)	0.3	0.4	0.8	-0.4	0.7	0.3	0.7	-0.9
Diabetes (mother)	1.0	1.3	2.3	-1.0	1.3	-1.5	-0.6	-1.1
Severe depression (siblings)	1.3	1.5	3.1	1.3	-1.8	0.5	1.5	-0.5
Pack years adult smoking proportion	0.3	0.5	1.1	0.6	0.4	1.1	-1.0	-0.2
Impedance of leg (right)	0.1	0.7	3.2	0.2	-1.8	-0.3	-0.2	-0.2
Leg fat-free mass (left)	0.3	1.5	4.7	-1.1	2.2	-0.4	-0.7	-0.9
Trunk fat percentage	1.0	3.9	8.4	-2.2	1.4	-1.4	-1.6	-2.9
Hand grip strength (right)	0.3	0.8	3.0	0.3	1.7	0.7	-0.1	0.6
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.0	0.8	-0.1	-0.5	-0.3
Current tobacco smoking	0.5	0.8	1.5	-0.6	-0.1	-1.0	-1.2	-1.2
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	0.2	0.0	0.5	0.6
Maternal smoking around birth	0.4	0.6	1.8	-0.5	0.4	1.3	-0.4	-0.7
Fed-up feelings	0.4	0.8	3.5	0.3	0.3	1.9	0.6	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.8	0.4	-0.0	1.7	0.7	-1.0
Relative age voice broke	1.0	1.5	2.6	1.3	-1.6	-1.2	-1.1	0.6
Taking other prescription medications	0.3	0.5	1.4	0.3	-1.2	-0.5	0.3	-0.8
Age when periods started (menarche)	0.5	1.2	2.1	1.1	0.2	1.1	-1.2	1.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.7	0.8	0.3	-0.4	0.7	0.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	7.1	1.1	-0.1	2.5	2.7	1.1
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	5.3	-1.6	-0.5	-0.9	-1.6	-2.3
Qualifications: CSEs or equivalent	0.4	0.6	2.0	-0.6	-0.3	0.6	-0.0	-1.4
Serious illness, injury or assault to yourself	0.4	0.4	1.7	-0.0	0.3	0.6	1.3	-0.2
High blood pressure	0.6	1.7	3.5	-1.3	-0.7	-1.1	-1.3	-1.9
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.2	1.0	0.4	0.3	1.5	1.0
Multivitamins +/- minerals	0.7	0.9	2.0	-0.9	-0.5	-0.4	-1.4	-1.1
Stomach or abdominal pain in last month	1.1	1.3	5.0	-0.8	0.3	-2.2	-0.2	-1.0
Supplements: Glucosamine	0.3	0.4	1.6	0.4	-0.6	1.3	0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	0.2	0.5	-0.4	-0.3	0.5
Medication: Atenolol	1.6	2.0	2.8	-1.5	-1.7	-1.4	-0.7	-1.6
Medication: Levothyroxine sodium	0.1	0.1	0.3	-0.1	-0.5	-0.4	-0.2	-0.1
Sitting height	0.1	1.0	2.1	-1.3	-0.2	-0.6	-1.4	-1.0
Chronic bronchitis/emphysema (father)	1.2	1.4	4.8	-0.7	-0.4	0.5	-2.2	-1.2
High blood pressure (mother)	1.9	2.7	4.0	-0.8	-1.9	-1.7	-1.5	-2.0
Body mass index (BMI)	0.7	3.1	6.6	-2.0	1.8	-1.2	-0.6	-2.6
Impedance of leg (left)	0.1	0.5	2.3	0.5	-1.5	0.0	-0.2	0.3
Leg predicted mass (left)	0.3	1.3	4.4	-1.0	2.1	-0.3	-0.6	-0.9
Trunk fat mass	1.0	4.1	7.9	-2.2	1.6	-1.6	-1.6	-2.8
Waist circumference	0.5	1.9	4.0	-1.2	2.0	-0.1	-1.0	-1.7
Number of incorrect matches in round	2.4	4.0	6.8	-2.6	-1.6	-0.8	-2.1	-2.4
Past tobacco smoking	0.1	0.2	0.9	0.0	0.2	0.9	0.1	0.3
Alcohol usually taken with meals	0.6	0.9	1.6	0.8	-1.3	-0.6	1.0	1.0
Nervous feelings	0.6	1.2	4.2	1.1	0.2	0.5	2.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.6	-1.1	-1.1	-0.8	-0.4	-1.6
Hearing difficulty/problems with background noise	1.0	1.5	3.2	1.8	-0.4	0.0	1.7	1.2
Hair/balding pattern: Pattern 2	1.0	1.3	2.3	-0.7	-0.9	-0.8	-1.5	-1.5
Had menopause	0.2	0.3	0.8	0.9	-0.1	-0.5	0.6	-0.2
Had other major operations	0.3	0.3	0.9	0.5	0.3	-0.0	0.9	0.7
Forced vital capacity (FVC)	0.2	0.9	3.5	-0.3	-0.6	-0.0	-1.9	0.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	6.8	0.8	0.1	2.6	2.1	1.7
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	2.3	0.8	-1.2	-1.5	0.9	-1.1
Qualifications: None of the above	0.4	0.8	2.7	-0.5	0.1	-0.1	-1.0	-1.6
Financial difficulties in last 2 years	0.3	0.4	0.8	0.5	0.5	0.9	0.9	0.2
Mouth/teeth dental problems	0.7	1.0	4.7	0.5	-0.0	0.1	-0.1	2.2
Heart attack	1.8	2.3	4.3	-1.4	-1.0	-2.1	-0.4	-2.0
Allergy	0.2	0.4	1.0	-0.0	-0.2	1.0	-0.6	0.6
Pain all over the body in last month	0.4	0.4	0.8	-0.8	0.9	-0.1	0.0	-0.8
Diabetes (self-reported)	0.4	0.6	1.7	-1.3	0.5	-0.4	-0.2	-0.9
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	1.8	-0.8	-1.3	-1.4	-0.9	-0.6
Medication: Ramipril	0.8	1.0	2.6	-0.5	1.2	-1.6	0.6	-0.6
Medication: Simvastatin	0.5	0.8	1.9	0.5	0.7	1.4	0.3	1.0
Fluid intelligence score	0.7	1.4	3.5	1.7	0.2	0.7	0.7	1.9
Illnesses of siblings	1.1	1.6	3.9	1.2	-0.3	1.5	0.5	2.0
Neuroticism score	0.2	0.4	1.1	0.6	-0.8	0.1	1.0	-0.3
Weight	0.8	3.7	5.9	-2.1	2.2	-1.2	-1.2	-2.4
Impedance of arm (right)	0.1	0.4	1.2	0.1	-1.1	-0.6	-0.6	0.4
Arm fat percentage (right)	1.0	3.8	7.7	-2.4	1.2	-1.5	-1.4	-2.8
Trunk fat-free mass	0.2	1.0	3.5	-0.7	1.9	-0.4	-0.5	-0.7
Hip circumference	0.4	1.7	3.8	-1.4	1.9	-0.4	-0.3	-1.6
Time employed in main current job	0.9	1.0	1.8	1.0	-0.9	1.3	-0.2	1.2
Alcohol intake versus 10 years previously	0.6	0.9	3.9	0.7	-0.2	2.0	0.0	-0.3
Father’s age at death	0.5	0.7	1.5	-1.2	0.6	-1.1	-0.2	-0.7
Worrier / anxious feelings	0.5	0.9	3.8	0.3	-1.9	-0.2	0.7	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.9	-0.5	-1.2	0.4	-0.9	-1.7
Falls in the last year	0.4	0.5	1.4	0.0	0.1	-1.2	0.7	-0.7
Hair/balding pattern: Pattern 3	1.2	1.8	3.2	1.8	0.2	0.3	1.6	1.8
Number of live births	0.3	0.4	0.9	-0.1	0.3	0.3	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.3	-0.1	0.4	0.7	-1.8	1.3
Pulse rate	0.2	0.4	1.1	0.7	0.2	1.1	-0.2	0.4
Happiness	0.2	0.3	0.9	-0.0	-0.6	0.9	-0.0	0.3
Noisy workplace	1.8	2.2	3.3	-1.8	-1.4	-0.9	-1.8	-1.3
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.1	0.7	-1.4	0.3	-0.3	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.6	0.7	-0.4	0.9	-0.5	1.6
Mouth/teeth dental problems: Dentures	0.7	1.2	3.8	-0.6	0.1	-1.3	-0.1	-1.9
Asthma	2.3	4.6	10.6	-1.9	0.4	-3.3	-0.7	-2.9
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.7	-1.6	-0.7	-1.6	-1.3	-1.4
Medication: Cholesterol lowering	0.5	0.8	2.1	-0.7	-1.1	-0.4	-1.4	0.0
Depression (self-reported)	1.2	1.5	4.2	2.1	-0.2	0.5	1.5	0.7
Medication: Lansoprazole	0.5	0.6	1.1	0.2	-1.0	-1.1	-0.8	-0.2
Prospective memory result	0.5	0.6	1.4	1.0	-0.4	-1.2	0.6	-0.1
Lung cancer (father)	1.0	1.2	3.2	1.3	1.8	0.2	0.8	0.6
Illnesses of mother	6.0	7.4	15.0	2.9	-0.0	2.4	2.7	3.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.1	-0.0	0.1	0.1	-1.4	1.1
Pulse wave Arterial Stiffness index	2.2	2.6	6.7	2.6	-0.3	1.2	1.4	1.7
Impedance of arm (left)	0.2	0.7	2.6	-0.2	-1.6	-0.8	-0.7	0.1
Arm fat mass (right)	1.0	4.1	7.6	-2.3	1.9	-1.5	-1.4	-2.8
Trunk predicted mass	0.2	0.9	3.1	-0.7	1.8	-0.5	-0.6	-0.7
Standing height	0.1	0.7	1.8	-0.3	1.3	-0.2	-1.3	0.2
Length of working week for main job	2.2	2.4	6.0	-1.9	-0.3	0.7	-2.4	-1.3
Exposure to tobacco smoke at home	0.5	0.5	1.1	-0.6	0.8	-0.4	-1.1	-0.7
Breastfed as a baby	2.2	2.7	5.8	2.2	0.3	1.4	1.2	2.4
Tense / ‘highly strung’	0.2	0.3	0.9	-0.4	-0.5	0.2	0.4	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.0	1.0	-0.5	1.2	1.7	0.5
Hair/balding pattern: Pattern 4	0.3	0.6	1.5	-1.2	0.3	0.5	-1.1	-0.5
Birth weight of first child	0.2	0.4	1.6	-0.3	1.2	0.3	0.4	-0.2
Peak expiratory flow (PEF)	0.7	1.6	5.4	-1.0	1.2	0.5	-2.3	0.0
Pulse wave reflection index	1.1	1.4	2.9	1.2	-1.7	0.3	1.2	1.1
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.0	-0.2	-1.2	-1.1	0.4	-1.4
Loud music exposure frequency	2.2	2.4	6.6	1.4	0.7	1.7	-0.0	2.6
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.9	1.3	-0.8	2.0	0.6	1.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.6	-0.2	-0.5	0.7	-0.8	-0.2
Blood clot in the leg (DVT)	0.8	1.0	2.6	-0.9	-0.9	-0.8	-0.5	-1.6
Medication: Paracetamol	1.4	2.3	4.2	-2.0	-0.5	-0.8	-1.7	-1.9
Headache pain in last month	1.1	1.8	5.5	-0.4	-2.4	-0.1	-1.8	0.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.9	1.3	-0.3	-0.1	1.7	0.4
Glaucoma (self-reported)	2.9	3.4	6.2	2.5	0.6	1.4	2.1	2.0
Gout (self-reported)	3.3	4.6	8.3	-1.7	-1.2	-2.7	-1.7	-2.9
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	0.8	0.9	-0.7	-0.1	0.8	0.6
Medication: Amlodipine	0.6	0.9	3.4	0.2	1.8	0.3	0.9	0.1
Medication: Ventolin 100micrograms inhaler	2.6	3.3	5.7	-2.0	-1.2	-2.1	-1.0	-2.4
Birth weight	0.2	0.4	1.2	0.1	-0.8	-1.1	-0.4	-0.1
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.7	-0.3	-0.4	-0.1	0.1	-1.3
High blood pressure (siblings)	0.4	0.5	1.1	-0.2	0.3	-1.0	0.7	-1.1
Forced vital capacity (FVC), Best measure	0.2	0.8	2.7	-0.0	-0.6	-0.2	-1.6	0.8
Body fat percentage	0.8	3.4	7.6	-2.0	1.1	-1.4	-1.4	-2.8
Leg fat percentage (right)	0.6	2.2	6.1	-1.8	0.9	-1.0	-0.4	-2.5
Arm fat-free mass (right)	0.2	1.3	4.0	-0.7	2.0	-0.5	-0.5	-1.2
Exposure to tobacco smoke outside home	0.5	0.7	1.5	-1.2	-0.0	0.5	-0.6	-1.1
Comparative body size at age 10	0.9	2.5	5.3	1.1	2.3	1.4	1.5	1.4
Number of full brothers	0.1	0.1	0.4	-0.3	0.3	0.1	-0.6	-0.1
Worry too long after embarrassment	0.5	0.8	3.4	-0.3	-1.8	0.4	-0.5	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.9	0.4	-0.5	0.0	0.9	-0.1
Wheeze or whistling in the chest in last year	1.5	2.7	5.4	-0.3	-1.9	-2.3	-0.4	-2.1
Number of children fathered	0.5	0.6	1.2	-1.1	0.5	0.2	-0.7	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.5	0.1	-1.2	-0.4	-0.4	0.5
Age at first live birth	0.7	1.2	2.9	0.8	-1.7	0.2	-0.1	1.6
Pulse wave peak to peak time	2.7	3.2	7.5	-2.7	0.2	-1.5	-1.6	-1.9
Health satisfaction	1.6	2.1	5.2	-1.4	-0.2	-1.6	-0.8	-2.3
Shortness of breath walking on level ground	4.9	5.8	11.2	-2.3	-1.4	-2.7	-1.8	-3.4
Qualifications: College or University degree	0.8	2.6	10.3	1.4	-0.4	0.1	0.6	3.2
Eye problems/disorders: None of the above	0.3	0.3	0.9	-0.1	0.9	-0.9	-0.3	-0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	0.0	0.7	0.2	-0.7	-0.3
Emphysema/chronic bronchitis	0.5	0.5	1.6	-0.7	0.1	-1.2	0.2	-0.7
Medication for pain relief, constipation, heartburn	2.6	4.4	8.1	2.8	0.9	1.9	1.9	2.4
Neck or shoulder pain in last month	0.1	0.2	0.8	0.2	0.2	-0.0	-0.9	-0.3
Medication: Blood pressure	0.8	1.3	2.5	-1.6	1.1	-0.6	-1.1	-1.0
Angina (self-reported)	0.3	0.4	0.9	0.3	0.9	0.5	0.8	-0.2
Migraine (self-reported)	0.3	0.4	0.9	-0.6	0.3	0.9	-0.7	-0.3
Medication: Ibuprofen	1.3	1.6	3.4	-1.8	-0.6	-1.2	-1.3	-1.0
Medication: Allopurinol	4.7	6.3	9.3	-1.9	-2.2	-3.0	-2.2	-3.0
Medication: Omeprazole	0.0	0.1	0.1	-0.4	0.3	0.2	-0.0	0.1
Medication: Seretide 50 evohaler	0.5	0.5	1.1	0.7	0.2	-0.9	1.0	0.5
Mean time to correctly identify matches	1.0	1.8	2.8	1.6	1.0	1.2	1.7	1.2
Heart disease (mother)	1.5	1.8	4.1	-0.9	1.3	-1.2	-1.0	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.7	0.8	0.7	0.3	1.6	1.6
Whole body fat mass	0.9	3.6	7.0	-2.1	1.5	-1.4	-1.5	-2.6
Leg fat mass (right)	0.5	2.0	4.3	-1.5	1.7	-0.8	-0.5	-2.1
Arm predicted mass (right)	0.3	1.4	3.8	-1.0	1.9	-0.5	-0.8	-1.2
Pulse rate, automated reading	0.1	0.3	1.3	0.4	-0.1	1.1	0.0	0.1
Alcohol intake frequency.	0.2	0.5	1.3	0.4	-1.0	1.1	-0.3	0.1
Comparative height size at age 10	0.2	1.0	2.0	-1.0	1.4	1.0	-1.0	-0.3
Number of full sisters	0.7	0.9	3.4	-1.0	-0.1	-0.1	0.2	-1.9
Suffer from ‘nerves’	0.6	1.0	1.8	1.1	-1.3	0.1	1.3	-0.5
Overall health rating	0.6	1.2	4.5	-0.6	-0.3	-1.1	-0.1	-2.1
Chest pain or discomfort	0.9	1.2	4.3	-0.6	0.3	-0.9	0.8	-2.1
Had major operations	0.4	0.5	1.2	0.6	-1.1	0.3	0.8	0.5
Age at last live birth	0.7	1.0	3.7	0.7	-0.1	0.9	-0.1	1.9
Family relationship satisfaction	0.5	0.6	1.9	0.6	-1.4	0.8	0.4	0.2
Leg pain on walking	0.6	0.7	1.8	-0.4	-1.0	0.5	1.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.1	-1.2	-0.6	-0.2	-0.1	-1.5
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.9	0.1	-0.0	0.8	0.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.7	0.2	1.3	0.1	-0.0	0.1
Medication: Aspirin	2.7	3.5	5.5	-2.3	-0.9	-2.0	-1.4	-2.3
Supplements: Vitamin C	1.2	1.5	3.2	0.4	1.7	1.8	0.5	0.9
Knee pain experienced in last month	0.3	0.4	1.2	-0.0	1.1	0.6	0.6	-0.5
Hypertension (Self-reported)	0.7	1.8	3.7	-1.5	-0.6	-1.1	-1.4	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.6	-1.6	-1.2	-0.8	-1.2	-0.5
Illnesses of father: Heart disease	0.9	1.2	2.6	1.4	-1.6	-0.5	0.9	-0.5
Illnesses of siblings: Diabetes	0.3	0.3	0.9	-0.6	0.4	0.1	-0.3	-0.9
Smoking status: Previous	0.2	0.3	1.0	-0.1	-1.0	-0.3	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	5.8	-2.2	-0.3	-2.4	-2.1	-2.4
Whole body fat-free mass	0.2	1.3	4.6	-0.9	2.1	-0.4	-0.7	-0.8
Leg fat-free mass (right)	0.3	1.4	5.1	-1.0	2.2	-0.3	-0.7	-0.7
Arm fat percentage (left)	1.0	3.8	8.4	-2.4	0.8	-1.6	-1.4	-2.9
Average weekly red wine intake	0.4	0.6	1.9	-0.8	-1.4	-0.3	-0.5	-0.6
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.5	-0.9	-0.7	0.6	-0.4
Mood swings	0.3	0.5	1.3	1.1	0.7	0.1	0.8	0.4
Loneliness, isolation	0.9	1.3	2.1	1.5	-0.0	1.4	1.3	0.7
Long-standing illness, disability or infirmity	1.0	1.5	2.5	-0.7	-1.5	-1.5	-0.2	-1.6
Ever had bowel cancer screening	0.4	0.5	0.8	0.7	-0.5	0.9	0.9	0.5
Diabetes diagnosed by doctor	0.3	0.6	1.4	-1.2	0.5	-0.2	-0.4	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	0.9	0.9	-0.8	0.6	0.7	1.0
Friendships satisfaction	0.4	0.5	0.9	0.7	-0.4	1.0	0.9	0.6
Qualifications: nursing, teaching	0.6	0.9	2.3	0.0	1.0	0.2	1.5	1.0
Commuting to job workplace: Walk	1.1	1.2	3.8	1.9	0.2	-1.0	0.7	0.8
Eye problems/disorders: Cataract	0.7	0.9	2.2	-0.9	-0.5	0.4	-1.5	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	0.4	0.3	1.3	1.0	0.0
Medication for cholesterol	0.4	0.5	1.1	0.5	-0.9	0.8	0.3	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.0	-1.0	-0.6	-0.9	0.2	-1.7
Back pain experienced in last month	1.1	1.6	4.3	-0.5	-1.7	-0.6	-0.5	-2.1
Mineral and other dietary supplements	0.5	0.6	1.5	-1.2	0.8	-0.3	-0.8	-0.5
Breast cancer (self-reported)	0.3	0.3	1.3	0.1	1.1	-0.2	0.4	0.3
Asthma (self-reported)	2.4	4.7	11.3	-2.0	0.4	-3.4	-0.6	-2.8
Osteoporosis (self-reported)	0.6	0.7	1.2	-0.9	0.0	-1.1	0.7	-1.1
Osteoarthritis (self-reported)	0.8	1.0	1.6	1.3	0.9	0.9	1.1	0.7
Medication: Aspirin	3.0	3.9	6.9	-2.6	-0.4	-2.1	-1.9	-2.1
Medication: Gliclazide	0.4	0.4	1.5	-0.3	0.4	-0.5	1.2	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.9	-0.0	0.4	1.0	0.1	0.9
Smoking status: Current	0.2	0.4	0.7	-0.3	0.4	-0.7	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.4	0.9	0.5	1.3	-0.2	1.5
Whole body water mass	0.2	1.1	4.1	-0.8	2.0	-0.3	-0.6	-0.7
Leg predicted mass (right)	0.2	1.3	4.8	-0.9	2.2	-0.2	-0.7	-0.6
Arm fat mass (left)	1.1	4.6	9.2	-2.5	1.6	-1.5	-1.6	-3.0
Number of self-reported non-cancer illnesses	0.1	0.1	0.5	0.1	-0.2	-0.7	-0.1	-0.1
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.5	0.3
Miserableness	0.8	1.3	3.0	1.7	-0.5	0.4	1.7	0.7
Guilty feelings	0.1	0.1	0.4	-0.3	-0.3	0.5	-0.0	-0.6
Wears glasses or contact lenses	0.6	0.7	1.2	-0.5	-1.0	-0.2	-1.1	-1.0
Ever taken oral contraceptive pill	0.9	1.0	2.4	-1.5	0.4	0.1	-0.6	-1.4
Hearing aid user	0.3	0.4	0.7	0.8	-0.4	0.5	0.9	0.3
Mother’s age at death	1.1	1.4	3.2	-1.7	-0.8	-0.1	-1.8	-0.7
Financial situation satisfaction	0.2	0.2	0.7	0.3	0.3	0.8	0.6	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	0.6	-0.9	-0.9	1.2	0.4
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.4	-0.8	-0.8	0.4	-0.5
Eye problems/disorders: Glaucoma	2.8	3.3	6.1	2.5	0.3	1.6	2.1	1.8
Medication: Blood pressure	1.1	2.1	5.0	-1.3	-0.9	-1.5	-0.9	-2.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.9	1.0	-0.0	-0.8	0.9	-0.9
Supplements: Fish oil (including cod liver oil)	3.2	4.2	8.5	2.9	0.3	1.3	1.8	2.7
High cholesterol (Self-reported)	0.1	0.1	0.6	0.1	0.8	0.1	0.1	0.3
Medication: Bendroflumethiazide	0.3	0.4	0.8	-0.5	-0.9	0.7	-0.3	-0.5
Medication: Paracetamol	2.1	3.2	5.9	-2.4	0.0	-1.3	-1.9	-2.2
Medication: Lisinopril	0.9	1.1	4.4	0.0	-2.1	-0.7	-0.8	0.3
Medication: Atorvastatin	0.5	0.6	1.9	-0.6	-0.2	-1.4	-0.7	-0.7
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.2	0.2	0.5	0.4	-0.0
Alcohol drinker status: Never	1.5	1.8	3.3	1.1	1.0	1.8	1.5	1.1
Ever smoked	0.4	0.6	2.4	-0.0	-0.5	-1.5	-0.4	-0.7
Basal metabolic rate	0.3	1.7	4.8	-1.2	2.2	-0.5	-0.8	-1.2
Leg fat percentage (left)	0.5	1.6	4.3	-1.4	1.1	-0.7	-0.3	-2.1
Arm fat-free mass (left)	0.4	1.9	5.2	-1.2	2.3	-0.7	-0.9	-1.4
Number of operations (self-reported)	0.3	0.4	1.2	-0.9	-0.3	-0.1	-0.2	-1.1
Average weekly beer plus cider intake	1.3	1.9	3.9	2.0	1.6	-0.3	1.0	1.4
Irritability	0.3	0.4	1.7	0.2	-1.3	-0.0	-0.3	-0.6
Risk taking	2.1	3.1	5.5	-2.4	-0.0	-1.4	-1.9	-2.1
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.2	0.2	0.0	-0.0	-0.3	0.4
Fractured/broken bones in last 5 years	0.2	0.3	1.3	0.1	1.2	-0.2	0.4	-0.1
Age started oral contraceptive pill	0.6	0.7	1.9	1.0	-0.6	-0.1	0.7	1.4
Diastolic blood pressure, automated reading	0.3	0.8	2.5	0.0	1.6	-0.1	-0.9	-0.8
Ever depressed for a whole week	0.2	0.3	0.6	0.8	0.2	-0.4	0.5	-0.5
Unable to work because of sickness or disability	0.5	0.7	2.4	0.4	-0.1	1.5	-0.4	-0.9
Commuting to job workplace: Cycle	0.6	0.7	1.6	-1.1	-0.4	-0.8	-0.4	-1.3
Myopia	0.9	1.2	3.2	0.5	1.8	1.3	0.6	0.9
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.6	1.0	1.0	1.4	0.8	1.6
Cholesterol lowering medication	0.5	0.7	3.1	-0.1	1.8	-0.1	0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.2	-0.4	0.4	-0.1	-0.4	0.2
Pain experienced in last month	0.1	0.2	0.5	-0.4	0.7	-0.0	-0.3	0.5
Supplements: Calcium	0.6	0.7	2.0	0.5	-1.4	0.5	0.3	-0.9
Basal cell carcinoma (self-reported)	0.4	0.5	1.3	0.8	0.6	-1.2	0.4	0.0
Heart attack/myocardial infarction (self-reported)	2.3	2.9	5.1	-1.6	-1.1	-2.2	-0.8	-2.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	-0.9	-0.7	-0.6	-0.5	-1.5
Heart disease (siblings)	0.6	0.8	1.7	-1.2	0.6	-0.5	-0.4	-1.3
Alcohol drinker status: Previous	0.9	1.0	4.6	0.2	-2.1	0.5	-0.3	-0.3
Pack years of smoking	0.3	0.5	1.1	0.9	0.3	1.1	-0.6	0.1
Impedance of whole body	0.1	0.7	2.7	0.1	-1.6	-0.4	-0.7	-0.0
Leg fat mass (left)	0.5	1.8	3.4	-1.3	1.8	-0.5	-0.6	-1.9
Arm predicted mass (left)	0.4	1.8	6.2	-0.9	2.5	-0.4	-0.8	-1.1