Hub : Genes

MOCS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adrenal Gland 0.1763 0.0681 5.7e-03 0.174 NA 0.152 NA 0.101 7.6e-07 NA 4.2e-06 NA 1.8e-04
2 GTEx Esophagus Mucosa 0.1400 0.0590 7.1e-03 -0.004 NA 0.020 NA -0.004 9.0e-01 NA 1.6e-02 NA 6.9e-01
3 ROSMAP Brain Pre-frontal Cortex 0.0981 0.0307 1.2e-05 0.011 0.029 0.075 0.029 0.064 1.1e-02 1.0e-04 6.4e-10 9.6e-05 1.1e-08
4 TCGA Colon Adenocarcinoma 0.1110 0.0680 3.3e-03 0.025 0.041 0.012 NA 0.015 1.3e-02 2.1e-03 6.5e-02 NA 4.2e-02
5 TCGA Thyroid Carcinoma 0.1380 0.0460 6.1e-15 0.108 0.159 0.121 NA 0.155 1.3e-10 2.8e-15 8.0e-12 NA 7.3e-15

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 1.3 -0.1 -1.1 0.3 0.5 0.0
Bipolar Disorder or Schizophrenia 0.3 0.7 1.2 -0.9 -0.9 0.7 -1.1 -0.3
Depressed Affect (Nagel 2018) 0.8 1.8 3.4 1.7 0.0 1.9 1.5 0.6
Depression (Nagel 2018) 1.2 1.9 5.4 1.2 -0.4 2.3 1.5 0.3
Intelligence (Savage-Jansen 2018) 1.5 4.5 11.9 2.7 -0.4 1.4 1.1 3.5
Neuroticism (Nagel 2018) 0.6 1.5 3.2 1.4 -1.8 0.8 1.2 0.1
Schizophrenia (2018) 0.5 1.0 3.1 -1.1 -0.2 0.7 -1.8 -0.3
Schizophrenia vs Biploar Disorder 0.2 0.3 0.8 0.7 -0.2 0.3 -0.0 0.9
Worry (Nagel 2018) 0.7 1.4 5.2 0.6 -2.3 -0.5 0.9 -0.7
Alzheimer’s Disease (in mother) 0.2 0.3 0.8 -0.5 0.9 0.3 0.3 -0.4
Alzheimer’s Disease (in father) 0.1 0.2 0.3 0.2 -0.3 -0.4 0.5 -0.6
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.2 0.4 -0.1 0.6 -0.4
Crohns Disease (2017) 0.2 0.4 1.0 -0.1 1.0 0.5 0.7 -0.3
Irritable Bowel Disease (IBD) 0.1 0.2 0.3 -0.4 0.4 0.3 0.6 -0.4
Ulcerative Colitis (UC) 0.1 0.2 0.3 -0.4 0.4 -0.5 0.4 -0.2
Major Depression (MDD) 0.8 0.9 2.7 -0.3 -1.0 -0.9 0.3 -1.6
Reaction Time 0.3 0.5 0.9 0.6 0.9 0.9 0.7 0.2
Verbal and Numeric Reasoning (VNR) 1.4 3.4 7.2 2.6 -0.6 1.0 1.2 2.7
Breast Cancer 0.9 2.1 4.1 -1.3 -0.7 -1.7 -1.3 -2.0
Ovarian Cancer 2.4 3.1 6.4 -1.5 -0.5 -2.1 -1.4 -2.5
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.9 1.4 2.3 1.5 -1.0 1.3 -0.2 1.3
Bipolar Disorder (2011) 0.6 0.6 1.7 1.1 -0.4 0.4 1.3 -0.1
Body Mass Index (BMI) (2010) 1.1 1.4 4.6 -0.3 1.2 -2.2 0.2 -1.0
Coronary Artery Disease (CAD) 2.8 3.3 5.0 -1.3 -2.2 -2.2 -1.8 -1.4
Crohns Disease (2012) 0.5 0.8 1.1 0.8 0.9 0.8 1.1 0.9
Mean Putamen Volume 3.4 3.9 7.1 2.7 1.2 1.1 1.8 2.5
Fasting Glucose 1.6 1.9 2.9 -1.6 0.1 -1.7 -1.0 -1.7
HbA1C 0.8 0.9 2.7 -0.4 1.1 -1.6 -0.6 0.1
HDL Cholesterol 0.2 0.3 0.8 0.5 -0.5 0.2 0.6 0.9
LDL Cholesterol 0.6 1.0 4.0 0.3 -0.4 -2.0 0.8 -0.3
Lupus 0.5 0.7 2.1 1.5 0.1 0.7 0.9 0.1
Neuroticism (2016) 1.1 1.5 4.9 1.3 -0.9 0.2 2.2 0.4
Primary Biliary Cirrhosis 2.1 2.9 8.7 -0.5 -0.7 -2.9 -0.5 -2.2
Rheumatoid Arthritis 0.2 0.2 0.6 0.2 -0.3 0.1 -0.6 0.8
Schizophrenia (2014) 0.2 0.5 1.9 -0.6 -0.2 0.3 -1.4 0.0
Triglycerides 0.3 0.6 2.1 -0.1 -0.1 -1.4 -0.8 -0.1
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.1 0.4 1.0 0.2 0.6 -0.3
Ulcerative Colitis 0.1 0.2 0.4 -0.5 -0.6 0.0 -0.6 -0.2
Blood Eosinophil Count 0.6 4.3 12.5 -1.7 -0.5 -3.5 -1.0 -2.3
Blood Platelet Count 2.0 23.0 35.9 -5.7 -0.7 -4.8 -4.8 -6.0
Blood Red Count 0.3 2.6 4.6 2.0 0.3 1.5 2.1 1.3
Blood White Count 1.5 11.5 19.8 -4.1 1.1 -3.6 -2.5 -4.5
Heel T-Score 3.1 24.4 37.9 4.7 2.2 5.3 6.2 5.5
BMI 0.7 3.9 6.9 -2.4 1.5 -2.1 -0.7 -2.6
Height 0.1 1.9 3.6 -1.4 0.8 -1.4 -1.9 -1.1
Waist Hip Ratio (WHR) 0.1 0.6 1.0 -0.5 0.8 0.4 -0.9 -1.0
Systolic Blood Pressure 0.3 1.6 2.5 -1.0 1.5 0.0 -1.4 -1.6
Smoking Status 0.3 0.7 1.4 -0.8 0.1 -0.9 -0.7 -1.2
Allergy or Eczema 0.7 1.7 2.9 1.7 -0.0 1.0 1.7 1.4
Cardiovascular Disease 0.2 0.7 1.6 -0.7 0.5 -1.3 -0.8 -0.6
Hypothyroidism (self reported) 0.1 0.3 1.0 0.6 -1.0 0.1 0.1 0.4
Respiratory disease 2.0 4.4 9.7 -2.1 -0.7 -2.5 -1.0 -3.1
Type 2 Diabetes (T2D) (2018) 1.4 2.7 5.2 -2.3 -0.1 -1.4 -1.3 -2.2
Lung FEV1/FVC ratio 0.4 1.8 4.0 0.0 2.0 1.8 -0.5 1.3
Lung FVC 0.4 1.9 6.3 -0.3 -1.5 -0.8 -2.5 0.4
Neuroticism 0.1 0.3 0.8 -0.1 0.2 -0.8 0.5 -0.9
Chronotype (morning person) 1.2 2.7 10.8 0.7 0.8 3.3 0.8 0.9
Hair Pigment 0.0 1.3 2.5 1.2 1.0 0.5 1.2 1.6
Tanning 0.1 1.5 4.0 -2.0 1.3 0.3 -1.0 -0.9
Hand grip strength (left) 0.2 0.5 0.8 0.6 0.9 0.7 0.5 0.9
Number of treatments/medications taken 1.8 3.3 5.6 -1.9 -1.6 -2.0 -0.7 -2.4
Average weekly spirits intake 0.3 0.3 0.9 -0.8 0.1 -1.0 -0.2 -0.4
Sensitivity / hurt feelings 0.6 1.0 3.1 1.0 -1.8 0.0 0.7 0.5
Frequency of depressed mood in last 2 weeks 2.1 2.9 6.7 1.7 -0.8 1.9 2.6 0.8
Hearing difficulty/problems: Yes 1.7 2.5 4.2 2.1 -1.1 0.5 1.9 1.8
Relative age of first facial hair 0.2 0.4 1.0 0.6 -0.6 -1.0 -0.0 0.6
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.1 1.0 -0.9 -0.5 0.2 0.9
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.5 -0.5 0.7 -0.2 0.2 -0.6
Ever had hysterectomy (womb removed) 0.3 0.3 1.3 0.4 -1.1 0.3 0.1 -0.0
Systolic blood pressure, automated reading 0.4 1.1 5.0 0.0 2.2 0.2 -0.4 -0.5
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.4 -1.5 -0.1 -0.2 0.2 -0.8
Angina 0.5 0.7 1.2 0.6 1.0 0.8 1.1 0.4
Medication for hormone replacement therapy 0.6 0.6 1.1 -0.6 -0.5 -0.7 -1.0 -1.0
Vitamin and mineral supplements 0.1 0.2 0.4 0.2 -0.2 -0.6 0.6 0.0
Supplements: Zinc 1.9 2.0 4.2 1.9 -0.7 1.1 2.0 1.0
Medication: Co-codamol 0.6 0.7 2.7 0.6 -1.6 0.2 -0.0 -0.6
Medication: Metformin 1.1 1.6 4.3 -1.4 -1.0 -0.6 -0.4 -2.1
Diabetes (father) 0.3 0.4 0.8 -0.4 0.7 0.3 0.7 -0.9
Diabetes (mother) 1.0 1.3 2.3 -1.0 1.3 -1.5 -0.6 -1.1
Severe depression (siblings) 1.3 1.5 3.1 1.3 -1.8 0.5 1.5 -0.5
Pack years adult smoking proportion 0.3 0.5 1.1 0.6 0.4 1.1 -1.0 -0.2
Impedance of leg (right) 0.1 0.7 3.2 0.2 -1.8 -0.3 -0.2 -0.2
Leg fat-free mass (left) 0.3 1.5 4.7 -1.1 2.2 -0.4 -0.7 -0.9
Trunk fat percentage 1.0 3.9 8.4 -2.2 1.4 -1.4 -1.6 -2.9
Hand grip strength (right) 0.3 0.8 3.0 0.3 1.7 0.7 -0.1 0.6
Townsend deprivation index at recruitment 0.1 0.2 0.6 -0.0 0.8 -0.1 -0.5 -0.3
Current tobacco smoking 0.5 0.8 1.5 -0.6 -0.1 -1.0 -1.2 -1.2
Average weekly fortified wine intake 0.2 0.2 0.4 0.6 0.2 0.0 0.5 0.6
Maternal smoking around birth 0.4 0.6 1.8 -0.5 0.4 1.3 -0.4 -0.7
Fed-up feelings 0.4 0.8 3.5 0.3 0.3 1.9 0.6 0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.8 0.4 -0.0 1.7 0.7 -1.0
Relative age voice broke 1.0 1.5 2.6 1.3 -1.6 -1.2 -1.1 0.6
Taking other prescription medications 0.3 0.5 1.4 0.3 -1.2 -0.5 0.3 -0.8
Age when periods started (menarche) 0.5 1.2 2.1 1.1 0.2 1.1 -1.2 1.4
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.7 0.8 0.3 -0.4 0.7 0.0
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 7.1 1.1 -0.1 2.5 2.7 1.1
Tinnitus: Yes, but not now, but have in the past 2.1 2.3 5.3 -1.6 -0.5 -0.9 -1.6 -2.3
Qualifications: CSEs or equivalent 0.4 0.6 2.0 -0.6 -0.3 0.6 -0.0 -1.4
Serious illness, injury or assault to yourself 0.4 0.4 1.7 -0.0 0.3 0.6 1.3 -0.2
High blood pressure 0.6 1.7 3.5 -1.3 -0.7 -1.1 -1.3 -1.9
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.2 1.0 0.4 0.3 1.5 1.0
Multivitamins +/- minerals 0.7 0.9 2.0 -0.9 -0.5 -0.4 -1.4 -1.1
Stomach or abdominal pain in last month 1.1 1.3 5.0 -0.8 0.3 -2.2 -0.2 -1.0
Supplements: Glucosamine 0.3 0.4 1.6 0.4 -0.6 1.3 0.1 -0.0
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.3 0.2 0.5 -0.4 -0.3 0.5
Medication: Atenolol 1.6 2.0 2.8 -1.5 -1.7 -1.4 -0.7 -1.6
Medication: Levothyroxine sodium 0.1 0.1 0.3 -0.1 -0.5 -0.4 -0.2 -0.1
Sitting height 0.1 1.0 2.1 -1.3 -0.2 -0.6 -1.4 -1.0
Chronic bronchitis/emphysema (father) 1.2 1.4 4.8 -0.7 -0.4 0.5 -2.2 -1.2
High blood pressure (mother) 1.9 2.7 4.0 -0.8 -1.9 -1.7 -1.5 -2.0
Body mass index (BMI) 0.7 3.1 6.6 -2.0 1.8 -1.2 -0.6 -2.6
Impedance of leg (left) 0.1 0.5 2.3 0.5 -1.5 0.0 -0.2 0.3
Leg predicted mass (left) 0.3 1.3 4.4 -1.0 2.1 -0.3 -0.6 -0.9
Trunk fat mass 1.0 4.1 7.9 -2.2 1.6 -1.6 -1.6 -2.8
Waist circumference 0.5 1.9 4.0 -1.2 2.0 -0.1 -1.0 -1.7
Number of incorrect matches in round 2.4 4.0 6.8 -2.6 -1.6 -0.8 -2.1 -2.4
Past tobacco smoking 0.1 0.2 0.9 0.0 0.2 0.9 0.1 0.3
Alcohol usually taken with meals 0.6 0.9 1.6 0.8 -1.3 -0.6 1.0 1.0
Nervous feelings 0.6 1.2 4.2 1.1 0.2 0.5 2.1 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.6 -1.1 -1.1 -0.8 -0.4 -1.6
Hearing difficulty/problems with background noise 1.0 1.5 3.2 1.8 -0.4 0.0 1.7 1.2
Hair/balding pattern: Pattern 2 1.0 1.3 2.3 -0.7 -0.9 -0.8 -1.5 -1.5
Had menopause 0.2 0.3 0.8 0.9 -0.1 -0.5 0.6 -0.2
Had other major operations 0.3 0.3 0.9 0.5 0.3 -0.0 0.9 0.7
Forced vital capacity (FVC) 0.2 0.9 3.5 -0.3 -0.6 -0.0 -1.9 0.9
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 6.8 0.8 0.1 2.6 2.1 1.7
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 2.3 0.8 -1.2 -1.5 0.9 -1.1
Qualifications: None of the above 0.4 0.8 2.7 -0.5 0.1 -0.1 -1.0 -1.6
Financial difficulties in last 2 years 0.3 0.4 0.8 0.5 0.5 0.9 0.9 0.2
Mouth/teeth dental problems 0.7 1.0 4.7 0.5 -0.0 0.1 -0.1 2.2
Heart attack 1.8 2.3 4.3 -1.4 -1.0 -2.1 -0.4 -2.0
Allergy 0.2 0.4 1.0 -0.0 -0.2 1.0 -0.6 0.6
Pain all over the body in last month 0.4 0.4 0.8 -0.8 0.9 -0.1 0.0 -0.8
Diabetes (self-reported) 0.4 0.6 1.7 -1.3 0.5 -0.4 -0.2 -0.9
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 1.8 -0.8 -1.3 -1.4 -0.9 -0.6
Medication: Ramipril 0.8 1.0 2.6 -0.5 1.2 -1.6 0.6 -0.6
Medication: Simvastatin 0.5 0.8 1.9 0.5 0.7 1.4 0.3 1.0
Fluid intelligence score 0.7 1.4 3.5 1.7 0.2 0.7 0.7 1.9
Illnesses of siblings 1.1 1.6 3.9 1.2 -0.3 1.5 0.5 2.0
Neuroticism score 0.2 0.4 1.1 0.6 -0.8 0.1 1.0 -0.3
Weight 0.8 3.7 5.9 -2.1 2.2 -1.2 -1.2 -2.4
Impedance of arm (right) 0.1 0.4 1.2 0.1 -1.1 -0.6 -0.6 0.4
Arm fat percentage (right) 1.0 3.8 7.7 -2.4 1.2 -1.5 -1.4 -2.8
Trunk fat-free mass 0.2 1.0 3.5 -0.7 1.9 -0.4 -0.5 -0.7
Hip circumference 0.4 1.7 3.8 -1.4 1.9 -0.4 -0.3 -1.6
Time employed in main current job 0.9 1.0 1.8 1.0 -0.9 1.3 -0.2 1.2
Alcohol intake versus 10 years previously 0.6 0.9 3.9 0.7 -0.2 2.0 0.0 -0.3
Father’s age at death 0.5 0.7 1.5 -1.2 0.6 -1.1 -0.2 -0.7
Worrier / anxious feelings 0.5 0.9 3.8 0.3 -1.9 -0.2 0.7 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.9 -0.5 -1.2 0.4 -0.9 -1.7
Falls in the last year 0.4 0.5 1.4 0.0 0.1 -1.2 0.7 -0.7
Hair/balding pattern: Pattern 3 1.2 1.8 3.2 1.8 0.2 0.3 1.6 1.8
Number of live births 0.3 0.4 0.9 -0.1 0.3 0.3 -0.9 -0.9
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 3.3 -0.1 0.4 0.7 -1.8 1.3
Pulse rate 0.2 0.4 1.1 0.7 0.2 1.1 -0.2 0.4
Happiness 0.2 0.3 0.9 -0.0 -0.6 0.9 -0.0 0.3
Noisy workplace 1.8 2.2 3.3 -1.8 -1.4 -0.9 -1.8 -1.3
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.1 0.7 -1.4 0.3 -0.3 1.8
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 2.6 0.7 -0.4 0.9 -0.5 1.6
Mouth/teeth dental problems: Dentures 0.7 1.2 3.8 -0.6 0.1 -1.3 -0.1 -1.9
Asthma 2.3 4.6 10.6 -1.9 0.4 -3.3 -0.7 -2.9
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 2.7 -1.6 -0.7 -1.6 -1.3 -1.4
Medication: Cholesterol lowering 0.5 0.8 2.1 -0.7 -1.1 -0.4 -1.4 0.0
Depression (self-reported) 1.2 1.5 4.2 2.1 -0.2 0.5 1.5 0.7
Medication: Lansoprazole 0.5 0.6 1.1 0.2 -1.0 -1.1 -0.8 -0.2
Prospective memory result 0.5 0.6 1.4 1.0 -0.4 -1.2 0.6 -0.1
Lung cancer (father) 1.0 1.2 3.2 1.3 1.8 0.2 0.8 0.6
Illnesses of mother 6.0 7.4 15.0 2.9 -0.0 2.4 2.7 3.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 2.1 -0.0 0.1 0.1 -1.4 1.1
Pulse wave Arterial Stiffness index 2.2 2.6 6.7 2.6 -0.3 1.2 1.4 1.7
Impedance of arm (left) 0.2 0.7 2.6 -0.2 -1.6 -0.8 -0.7 0.1
Arm fat mass (right) 1.0 4.1 7.6 -2.3 1.9 -1.5 -1.4 -2.8
Trunk predicted mass 0.2 0.9 3.1 -0.7 1.8 -0.5 -0.6 -0.7
Standing height 0.1 0.7 1.8 -0.3 1.3 -0.2 -1.3 0.2
Length of working week for main job 2.2 2.4 6.0 -1.9 -0.3 0.7 -2.4 -1.3
Exposure to tobacco smoke at home 0.5 0.5 1.1 -0.6 0.8 -0.4 -1.1 -0.7
Breastfed as a baby 2.2 2.7 5.8 2.2 0.3 1.4 1.2 2.4
Tense / ‘highly strung’ 0.2 0.3 0.9 -0.4 -0.5 0.2 0.4 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.0 1.0 -0.5 1.2 1.7 0.5
Hair/balding pattern: Pattern 4 0.3 0.6 1.5 -1.2 0.3 0.5 -1.1 -0.5
Birth weight of first child 0.2 0.4 1.6 -0.3 1.2 0.3 0.4 -0.2
Peak expiratory flow (PEF) 0.7 1.6 5.4 -1.0 1.2 0.5 -2.3 0.0
Pulse wave reflection index 1.1 1.4 2.9 1.2 -1.7 0.3 1.2 1.1
Ever highly irritable/argumentative for 2 days 0.8 1.0 2.0 -0.2 -1.2 -1.1 0.4 -1.4
Loud music exposure frequency 2.2 2.4 6.6 1.4 0.7 1.7 -0.0 2.6
Qualifications: O levels/GCSEs or equivalent 1.3 2.0 3.9 1.3 -0.8 2.0 0.6 1.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.6 -0.2 -0.5 0.7 -0.8 -0.2
Blood clot in the leg (DVT) 0.8 1.0 2.6 -0.9 -0.9 -0.8 -0.5 -1.6
Medication: Paracetamol 1.4 2.3 4.2 -2.0 -0.5 -0.8 -1.7 -1.9
Headache pain in last month 1.1 1.8 5.5 -0.4 -2.4 -0.1 -1.8 0.3
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.9 1.3 -0.3 -0.1 1.7 0.4
Glaucoma (self-reported) 2.9 3.4 6.2 2.5 0.6 1.4 2.1 2.0
Gout (self-reported) 3.3 4.6 8.3 -1.7 -1.2 -2.7 -1.7 -2.9
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 0.8 0.9 -0.7 -0.1 0.8 0.6
Medication: Amlodipine 0.6 0.9 3.4 0.2 1.8 0.3 0.9 0.1
Medication: Ventolin 100micrograms inhaler 2.6 3.3 5.7 -2.0 -1.2 -2.1 -1.0 -2.4
Birth weight 0.2 0.4 1.2 0.1 -0.8 -1.1 -0.4 -0.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.7 -0.3 -0.4 -0.1 0.1 -1.3
High blood pressure (siblings) 0.4 0.5 1.1 -0.2 0.3 -1.0 0.7 -1.1
Forced vital capacity (FVC), Best measure 0.2 0.8 2.7 -0.0 -0.6 -0.2 -1.6 0.8
Body fat percentage 0.8 3.4 7.6 -2.0 1.1 -1.4 -1.4 -2.8
Leg fat percentage (right) 0.6 2.2 6.1 -1.8 0.9 -1.0 -0.4 -2.5
Arm fat-free mass (right) 0.2 1.3 4.0 -0.7 2.0 -0.5 -0.5 -1.2
Exposure to tobacco smoke outside home 0.5 0.7 1.5 -1.2 -0.0 0.5 -0.6 -1.1
Comparative body size at age 10 0.9 2.5 5.3 1.1 2.3 1.4 1.5 1.4
Number of full brothers 0.1 0.1 0.4 -0.3 0.3 0.1 -0.6 -0.1
Worry too long after embarrassment 0.5 0.8 3.4 -0.3 -1.8 0.4 -0.5 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.9 0.4 -0.5 0.0 0.9 -0.1
Wheeze or whistling in the chest in last year 1.5 2.7 5.4 -0.3 -1.9 -2.3 -0.4 -2.1
Number of children fathered 0.5 0.6 1.2 -1.1 0.5 0.2 -0.7 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.5 0.1 -1.2 -0.4 -0.4 0.5
Age at first live birth 0.7 1.2 2.9 0.8 -1.7 0.2 -0.1 1.6
Pulse wave peak to peak time 2.7 3.2 7.5 -2.7 0.2 -1.5 -1.6 -1.9
Health satisfaction 1.6 2.1 5.2 -1.4 -0.2 -1.6 -0.8 -2.3
Shortness of breath walking on level ground 4.9 5.8 11.2 -2.3 -1.4 -2.7 -1.8 -3.4
Qualifications: College or University degree 0.8 2.6 10.3 1.4 -0.4 0.1 0.6 3.2
Eye problems/disorders: None of the above 0.3 0.3 0.9 -0.1 0.9 -0.9 -0.3 -0.0
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.6 0.0 0.7 0.2 -0.7 -0.3
Emphysema/chronic bronchitis 0.5 0.5 1.6 -0.7 0.1 -1.2 0.2 -0.7
Medication for pain relief, constipation, heartburn 2.6 4.4 8.1 2.8 0.9 1.9 1.9 2.4
Neck or shoulder pain in last month 0.1 0.2 0.8 0.2 0.2 -0.0 -0.9 -0.3
Medication: Blood pressure 0.8 1.3 2.5 -1.6 1.1 -0.6 -1.1 -1.0
Angina (self-reported) 0.3 0.4 0.9 0.3 0.9 0.5 0.8 -0.2
Migraine (self-reported) 0.3 0.4 0.9 -0.6 0.3 0.9 -0.7 -0.3
Medication: Ibuprofen 1.3 1.6 3.4 -1.8 -0.6 -1.2 -1.3 -1.0
Medication: Allopurinol 4.7 6.3 9.3 -1.9 -2.2 -3.0 -2.2 -3.0
Medication: Omeprazole 0.0 0.1 0.1 -0.4 0.3 0.2 -0.0 0.1
Medication: Seretide 50 evohaler 0.5 0.5 1.1 0.7 0.2 -0.9 1.0 0.5
Mean time to correctly identify matches 1.0 1.8 2.8 1.6 1.0 1.2 1.7 1.2
Heart disease (mother) 1.5 1.8 4.1 -0.9 1.3 -1.2 -1.0 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.7 0.8 0.7 0.3 1.6 1.6
Whole body fat mass 0.9 3.6 7.0 -2.1 1.5 -1.4 -1.5 -2.6
Leg fat mass (right) 0.5 2.0 4.3 -1.5 1.7 -0.8 -0.5 -2.1
Arm predicted mass (right) 0.3 1.4 3.8 -1.0 1.9 -0.5 -0.8 -1.2
Pulse rate, automated reading 0.1 0.3 1.3 0.4 -0.1 1.1 0.0 0.1
Alcohol intake frequency. 0.2 0.5 1.3 0.4 -1.0 1.1 -0.3 0.1
Comparative height size at age 10 0.2 1.0 2.0 -1.0 1.4 1.0 -1.0 -0.3
Number of full sisters 0.7 0.9 3.4 -1.0 -0.1 -0.1 0.2 -1.9
Suffer from ‘nerves’ 0.6 1.0 1.8 1.1 -1.3 0.1 1.3 -0.5
Overall health rating 0.6 1.2 4.5 -0.6 -0.3 -1.1 -0.1 -2.1
Chest pain or discomfort 0.9 1.2 4.3 -0.6 0.3 -0.9 0.8 -2.1
Had major operations 0.4 0.5 1.2 0.6 -1.1 0.3 0.8 0.5
Age at last live birth 0.7 1.0 3.7 0.7 -0.1 0.9 -0.1 1.9
Family relationship satisfaction 0.5 0.6 1.9 0.6 -1.4 0.8 0.4 0.2
Leg pain on walking 0.6 0.7 1.8 -0.4 -1.0 0.5 1.4 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 2.1 -1.2 -0.6 -0.2 -0.1 -1.5
Commuting to job workplace: Car/motor vehicle 0.3 0.4 0.9 0.1 -0.0 0.8 0.4 0.9
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 1.7 0.2 1.3 0.1 -0.0 0.1
Medication: Aspirin 2.7 3.5 5.5 -2.3 -0.9 -2.0 -1.4 -2.3
Supplements: Vitamin C 1.2 1.5 3.2 0.4 1.7 1.8 0.5 0.9
Knee pain experienced in last month 0.3 0.4 1.2 -0.0 1.1 0.6 0.6 -0.5
Hypertension (Self-reported) 0.7 1.8 3.7 -1.5 -0.6 -1.1 -1.4 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.6 -1.6 -1.2 -0.8 -1.2 -0.5
Illnesses of father: Heart disease 0.9 1.2 2.6 1.4 -1.6 -0.5 0.9 -0.5
Illnesses of siblings: Diabetes 0.3 0.3 0.9 -0.6 0.4 0.1 -0.3 -0.9
Smoking status: Previous 0.2 0.3 1.0 -0.1 -1.0 -0.3 -0.5 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 2.0 4.1 5.8 -2.2 -0.3 -2.4 -2.1 -2.4
Whole body fat-free mass 0.2 1.3 4.6 -0.9 2.1 -0.4 -0.7 -0.8
Leg fat-free mass (right) 0.3 1.4 5.1 -1.0 2.2 -0.3 -0.7 -0.7
Arm fat percentage (left) 1.0 3.8 8.4 -2.4 0.8 -1.6 -1.4 -2.9
Average weekly red wine intake 0.4 0.6 1.9 -0.8 -1.4 -0.3 -0.5 -0.6
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.8 0.5 -0.9 -0.7 0.6 -0.4
Mood swings 0.3 0.5 1.3 1.1 0.7 0.1 0.8 0.4
Loneliness, isolation 0.9 1.3 2.1 1.5 -0.0 1.4 1.3 0.7
Long-standing illness, disability or infirmity 1.0 1.5 2.5 -0.7 -1.5 -1.5 -0.2 -1.6
Ever had bowel cancer screening 0.4 0.5 0.8 0.7 -0.5 0.9 0.9 0.5
Diabetes diagnosed by doctor 0.3 0.6 1.4 -1.2 0.5 -0.2 -0.4 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 0.9 0.9 -0.8 0.6 0.7 1.0
Friendships satisfaction 0.4 0.5 0.9 0.7 -0.4 1.0 0.9 0.6
Qualifications: nursing, teaching 0.6 0.9 2.3 0.0 1.0 0.2 1.5 1.0
Commuting to job workplace: Walk 1.1 1.2 3.8 1.9 0.2 -1.0 0.7 0.8
Eye problems/disorders: Cataract 0.7 0.9 2.2 -0.9 -0.5 0.4 -1.5 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.7 0.4 0.3 1.3 1.0 0.0
Medication for cholesterol 0.4 0.5 1.1 0.5 -0.9 0.8 0.3 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 3.0 -1.0 -0.6 -0.9 0.2 -1.7
Back pain experienced in last month 1.1 1.6 4.3 -0.5 -1.7 -0.6 -0.5 -2.1
Mineral and other dietary supplements 0.5 0.6 1.5 -1.2 0.8 -0.3 -0.8 -0.5
Breast cancer (self-reported) 0.3 0.3 1.3 0.1 1.1 -0.2 0.4 0.3
Asthma (self-reported) 2.4 4.7 11.3 -2.0 0.4 -3.4 -0.6 -2.8
Osteoporosis (self-reported) 0.6 0.7 1.2 -0.9 0.0 -1.1 0.7 -1.1
Osteoarthritis (self-reported) 0.8 1.0 1.6 1.3 0.9 0.9 1.1 0.7
Medication: Aspirin 3.0 3.9 6.9 -2.6 -0.4 -2.1 -1.9 -2.1
Medication: Gliclazide 0.4 0.4 1.5 -0.3 0.4 -0.5 1.2 -0.4
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 -0.0 0.4 1.0 0.1 0.9
Smoking status: Current 0.2 0.4 0.7 -0.3 0.4 -0.7 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.4 0.9 0.5 1.3 -0.2 1.5
Whole body water mass 0.2 1.1 4.1 -0.8 2.0 -0.3 -0.6 -0.7
Leg predicted mass (right) 0.2 1.3 4.8 -0.9 2.2 -0.2 -0.7 -0.6
Arm fat mass (left) 1.1 4.6 9.2 -2.5 1.6 -1.5 -1.6 -3.0
Number of self-reported non-cancer illnesses 0.1 0.1 0.5 0.1 -0.2 -0.7 -0.1 -0.1
Average weekly champagne plus white wine intake 0.1 0.1 0.2 -0.3 -0.4 -0.2 0.5 0.3
Miserableness 0.8 1.3 3.0 1.7 -0.5 0.4 1.7 0.7
Guilty feelings 0.1 0.1 0.4 -0.3 -0.3 0.5 -0.0 -0.6
Wears glasses or contact lenses 0.6 0.7 1.2 -0.5 -1.0 -0.2 -1.1 -1.0
Ever taken oral contraceptive pill 0.9 1.0 2.4 -1.5 0.4 0.1 -0.6 -1.4
Hearing aid user 0.3 0.4 0.7 0.8 -0.4 0.5 0.9 0.3
Mother’s age at death 1.1 1.4 3.2 -1.7 -0.8 -0.1 -1.8 -0.7
Financial situation satisfaction 0.2 0.2 0.7 0.3 0.3 0.8 0.6 -0.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.5 0.6 -0.9 -0.9 1.2 0.4
Commuting to job workplace: Public transport 0.3 0.4 0.7 0.4 -0.8 -0.8 0.4 -0.5
Eye problems/disorders: Glaucoma 2.8 3.3 6.1 2.5 0.3 1.6 2.1 1.8
Medication: Blood pressure 1.1 2.1 5.0 -1.3 -0.9 -1.5 -0.9 -2.2
Pain type(s) experienced in last month: Hip pain 0.5 0.6 0.9 1.0 -0.0 -0.8 0.9 -0.9
Supplements: Fish oil (including cod liver oil) 3.2 4.2 8.5 2.9 0.3 1.3 1.8 2.7
High cholesterol (Self-reported) 0.1 0.1 0.6 0.1 0.8 0.1 0.1 0.3
Medication: Bendroflumethiazide 0.3 0.4 0.8 -0.5 -0.9 0.7 -0.3 -0.5
Medication: Paracetamol 2.1 3.2 5.9 -2.4 0.0 -1.3 -1.9 -2.2
Medication: Lisinopril 0.9 1.1 4.4 0.0 -2.1 -0.7 -0.8 0.3
Medication: Atorvastatin 0.5 0.6 1.9 -0.6 -0.2 -1.4 -0.7 -0.7
Illnesses of father: High blood pressure 0.1 0.1 0.2 -0.2 0.2 0.5 0.4 -0.0
Alcohol drinker status: Never 1.5 1.8 3.3 1.1 1.0 1.8 1.5 1.1
Ever smoked 0.4 0.6 2.4 -0.0 -0.5 -1.5 -0.4 -0.7
Basal metabolic rate 0.3 1.7 4.8 -1.2 2.2 -0.5 -0.8 -1.2
Leg fat percentage (left) 0.5 1.6 4.3 -1.4 1.1 -0.7 -0.3 -2.1
Arm fat-free mass (left) 0.4 1.9 5.2 -1.2 2.3 -0.7 -0.9 -1.4
Number of operations (self-reported) 0.3 0.4 1.2 -0.9 -0.3 -0.1 -0.2 -1.1
Average weekly beer plus cider intake 1.3 1.9 3.9 2.0 1.6 -0.3 1.0 1.4
Irritability 0.3 0.4 1.7 0.2 -1.3 -0.0 -0.3 -0.6
Risk taking 2.1 3.1 5.5 -2.4 -0.0 -1.4 -1.9 -2.1
Ever had prostate specific antigen (PSA) test 0.0 0.1 0.2 0.2 0.0 -0.0 -0.3 0.4
Fractured/broken bones in last 5 years 0.2 0.3 1.3 0.1 1.2 -0.2 0.4 -0.1
Age started oral contraceptive pill 0.6 0.7 1.9 1.0 -0.6 -0.1 0.7 1.4
Diastolic blood pressure, automated reading 0.3 0.8 2.5 0.0 1.6 -0.1 -0.9 -0.8
Ever depressed for a whole week 0.2 0.3 0.6 0.8 0.2 -0.4 0.5 -0.5
Unable to work because of sickness or disability 0.5 0.7 2.4 0.4 -0.1 1.5 -0.4 -0.9
Commuting to job workplace: Cycle 0.6 0.7 1.6 -1.1 -0.4 -0.8 -0.4 -1.3
Myopia 0.9 1.2 3.2 0.5 1.8 1.3 0.6 0.9
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.6 1.0 1.0 1.4 0.8 1.6
Cholesterol lowering medication 0.5 0.7 3.1 -0.1 1.8 -0.1 0.4 -0.3
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 -0.4 0.4 -0.1 -0.4 0.2
Pain experienced in last month 0.1 0.2 0.5 -0.4 0.7 -0.0 -0.3 0.5
Supplements: Calcium 0.6 0.7 2.0 0.5 -1.4 0.5 0.3 -0.9
Basal cell carcinoma (self-reported) 0.4 0.5 1.3 0.8 0.6 -1.2 0.4 0.0
Heart attack/myocardial infarction (self-reported) 2.3 2.9 5.1 -1.6 -1.1 -2.2 -0.8 -2.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.3 -0.9 -0.7 -0.6 -0.5 -1.5
Heart disease (siblings) 0.6 0.8 1.7 -1.2 0.6 -0.5 -0.4 -1.3
Alcohol drinker status: Previous 0.9 1.0 4.6 0.2 -2.1 0.5 -0.3 -0.3
Pack years of smoking 0.3 0.5 1.1 0.9 0.3 1.1 -0.6 0.1
Impedance of whole body 0.1 0.7 2.7 0.1 -1.6 -0.4 -0.7 -0.0
Leg fat mass (left) 0.5 1.8 3.4 -1.3 1.8 -0.5 -0.6 -1.9
Arm predicted mass (left) 0.4 1.8 6.2 -0.9 2.5 -0.4 -0.8 -1.1