TWAS hub - MPEG1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0686	0.0176	3.5e-12	0.036	0.045	0.052	0.051	0.057	7.3e-12	2.8e-14	2.1e-16	3.6e-16	8.3e-18
2	YFS	Blood	0.0313	0.0117	3.3e-05	0.018	0.012	0.014	0.014	0.020	9.5e-07	4.8e-05	2.0e-05	1.1e-05	3.2e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bipolar Disorder (2011)	4.7	4.5	6.2	-2.5	1.7
Medication: Omeprazole	4.3	5.1	9.1	3.0	-1.0
Ever had hysterectomy (womb removed)	4.2	4.7	7.6	2.8	-1.4
Family relationship satisfaction	4.2	5.2	5.5	2.2	-2.3
Friendships satisfaction	4.2	5.3	8.5	2.9	-1.4
Ever unenthusiastic/disinterested for a whole week	3.8	4.7	7.3	2.7	-1.5
Bilateral oophorectomy (both ovaries removed)	3.6	4.1	5.3	2.3	-1.7
Ever depressed for a whole week	3.4	4.2	6.1	1.5	-2.5
Bipolar Disorder (2018)	3.1	5.0	9.4	-3.1	0.7
Back pain experienced in last month	3.1	4.5	6.7	2.6	1.5
Number of operations (self-reported)	3.1	4.6	8.6	2.9	0.7
Prostate Cancer	3.0	4.2	6.7	-1.3	2.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	6.4	2.5	0.4
Knee pain experienced in last month	2.6	4.0	7.9	2.8	0.4
Long-standing illness, disability or infirmity	2.3	3.5	5.2	2.3	1.4
Schizophrenia vs Biploar Disorder	2.2	2.9	5.3	2.3	-0.8
Rheumatoid Arthritis	2.2	3.1	4.4	2.1	-1.3
Severe depression (siblings)	2.2	2.4	2.9	1.7	1.4
Financial situation satisfaction	2.2	2.7	5.3	-0.3	-2.3
Ever had prostate specific antigen (PSA) test	2.1	2.4	3.3	-1.2	1.8
Unable to work because of sickness or disability	2.1	2.7	4.9	-0.7	2.2
Medication for hormone replacement therapy	1.9	2.1	4.2	-0.2	2.1
Pain experienced in last month	1.9	3.2	6.1	-2.5	-0.5
Crohns Disease (2012)	1.8	2.9	4.6	1.1	-2.1
Average weekly red wine intake	1.8	2.6	5.0	2.2	0.4
Eye problems/disorders: Cataract	1.8	2.1	4.1	-2.0	0.4
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	5.7	0.4	2.4
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	2.4	1.6	-1.4
Blood Platelet Count	1.6	18.6	29.2	-2.8	5.4
Relative age of first facial hair	1.6	3.4	5.2	2.3	1.3
Breast cancer (self-reported)	1.6	1.9	2.3	-1.2	-1.5
Fractured/broken bones in last 5 years	1.6	2.1	4.2	2.0	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.4	1.8	-0.7
Age at First Birth	1.5	2.2	4.2	-2.1	0.5
Financial difficulties in last 2 years	1.5	2.1	3.5	-1.9	-0.8
Number of full brothers	1.4	1.8	1.8	1.3	-1.3
Medication: Ibuprofen	1.4	1.6	1.7	1.3	-1.2
Medication: Aspirin	1.4	1.8	3.2	0.7	1.8
Number of self-reported non-cancer illnesses	1.4	2.4	4.7	2.2	0.1
Crohns Disease (2017)	1.3	2.9	5.3	-0.8	-2.3
Major Depression (MDD)	1.3	1.5	3.0	1.7	-0.1
Stomach or abdominal pain in last month	1.3	1.6	3.1	1.8	0.4
Hip circumference	1.3	5.4	10.4	0.7	-3.2
Leg pain on walking	1.3	1.6	2.9	1.7	0.6
Supplements: Vitamin C	1.3	1.5	1.5	-1.2	1.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.4	-0.0	1.8
Alcohol drinker status: Never	1.3	1.5	2.6	1.6	-0.6
Intelligence (Savage-Jansen 2018)	1.2	3.8	6.4	2.5	1.1
Heel T-Score	1.2	9.4	18.5	4.3	0.6
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	1.5	-1.0	1.2
Multivitamins +/- minerals	1.2	1.6	2.9	0.5	1.7
Had other major operations	1.2	1.5	2.9	1.7	0.3
Mouth/teeth dental problems: Dentures	1.2	2.1	3.0	1.1	1.7
Blood clot in the leg (DVT)	1.2	1.5	2.2	0.9	-1.5
Alcohol drinker status: Previous	1.2	1.4	2.2	-1.5	0.8
Alzheimer’s Disease (in father)	1.1	1.1	2.0	0.5	1.4
Vitamin and mineral supplements	1.1	1.5	2.8	0.4	-1.7
Taking other prescription medications	1.1	1.7	3.4	1.8	0.3
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.0	0.8	-1.4
Medication: Atenolol	1.1	1.4	2.0	1.4	0.9
Depression (self-reported)	1.1	1.3	2.0	1.4	-0.8
Smoking status: Previous	1.1	1.7	1.9	-1.4	-1.2
Qualifications: nursing, teaching	1.1	1.6	2.6	1.6	0.9
Osteoporosis (self-reported)	1.1	1.4	1.9	-1.0	-1.4
Medication: Aspirin	1.1	1.4	2.0	0.9	1.4
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.0	0.9	-1.4
Verbal and Numeric Reasoning (VNR)	1.0	2.3	4.3	2.1	0.5
Body Mass Index (BMI) (2010)	1.0	1.3	2.7	0.0	-1.6
Lung FEV1/FVC ratio	1.0	4.9	7.1	1.7	-2.7
Average weekly spirits intake	1.0	1.2	1.7	1.3	-0.9
Impedance of leg (right)	1.0	4.8	7.6	-1.4	2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.7	1.3	-0.9
Relative age voice broke	1.0	1.5	2.9	1.7	-0.3
Body mass index (BMI)	1.0	4.4	7.6	1.1	-2.8
Number of live births	1.0	1.5	2.1	0.9	-1.4
Medication: Lansoprazole	1.0	1.2	2.4	1.5	0.1
Pulse wave reflection index	1.0	1.2	2.2	1.5	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.3	-1.5	0.1
Mother’s age at death	1.0	1.3	2.0	-1.4	0.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.3	-1.5	-0.3
Waist Hip Ratio (WHR)	0.9	4.0	6.2	-1.3	2.5
Number of treatments/medications taken	0.9	1.6	2.2	1.5	1.0
Medication: Co-codamol	0.9	1.0	2.0	1.4	0.1
Age when periods started (menarche)	0.9	2.2	4.0	2.0	-0.7
Past tobacco smoking	0.9	1.7	2.2	1.1	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.5	1.9	0.8
Mouth/teeth dental problems	0.9	1.4	2.1	-0.8	-1.4
Medication: Ramipril	0.9	1.2	2.2	1.5	-0.3
Pulse wave Arterial Stiffness index	0.9	1.0	1.6	1.3	-0.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	1.5	0.1
Wheeze or whistling in the chest in last year	0.9	1.5	2.8	0.5	-1.7
Number of children fathered	0.9	1.0	1.9	0.1	-1.4
Neck or shoulder pain in last month	0.9	1.3	2.5	0.2	1.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.3	1.2	-0.8
Average weekly champagne plus white wine intake	0.9	1.2	1.4	1.0	-1.2
Alzheimer’s Disease (including proxy)	0.8	1.2	1.5	1.0	1.2
Primary Biliary Cirrhosis	0.8	1.1	1.3	0.9	1.1
Pack years adult smoking proportion	0.8	1.2	2.0	-1.4	0.6
Trunk fat percentage	0.8	3.0	4.7	1.2	-2.2
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.5	-0.1	1.9
Number of incorrect matches in round	0.8	1.3	2.7	-0.1	1.6
Pain all over the body in last month	0.8	0.9	0.9	1.0	-0.9
Breastfed as a baby	0.8	1.0	1.5	1.2	0.8
Pulse rate, automated reading	0.8	2.7	5.0	-2.2	-0.7
Had major operations	0.8	1.0	1.0	1.0	1.0
Arm fat percentage (left)	0.8	3.3	5.2	1.2	-2.3
Wears glasses or contact lenses	0.8	0.9	1.5	0.5	-1.2
Age started oral contraceptive pill	0.8	1.0	1.6	0.6	-1.2
Leg fat mass (left)	0.8	3.2	5.2	1.1	-2.3
Ever used hormone-replacement therapy (HRT)	0.7	0.8	1.4	1.2	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	3.1	1.8	0.2
Serious illness, injury or assault to yourself	0.7	0.9	1.1	1.0	-0.8
Trunk fat mass	0.7	3.0	4.5	1.2	-2.1
Weight	0.7	3.3	5.3	1.1	-2.3
Arm fat percentage (right)	0.7	2.8	4.8	0.9	-2.2
Worrier / anxious feelings	0.7	1.3	1.4	1.2	1.1
Arm fat mass (right)	0.7	3.1	4.7	1.2	-2.2
Length of working week for main job	0.7	0.7	0.9	0.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.2	1.1	1.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	1.4	-0.1
Body fat percentage	0.7	2.8	4.4	1.1	-2.1
Worry too long after embarrassment	0.7	1.2	2.0	-0.6	1.4
Eye problems/disorders: None of the above	0.7	0.8	1.0	0.7	-1.0
Whole body fat mass	0.7	2.8	4.2	1.2	-2.1
Leg fat mass (right)	0.7	2.8	4.5	1.0	-2.1
Leg fat-free mass (right)	0.7	3.7	5.9	1.2	-2.4
Leg predicted mass (right)	0.7	3.7	5.7	1.3	-2.4
Medication: Lisinopril	0.7	0.9	1.6	-0.5	-1.3
Medication: Atorvastatin	0.7	0.9	0.9	0.9	0.9
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.1	-0.0	2.0
Heart disease (siblings)	0.7	0.9	1.6	1.3	0.4
Bipolar Disorder or Schizophrenia	0.6	1.6	2.3	-1.5	0.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.2	0.5	1.1
BMI	0.6	3.3	6.2	0.7	-2.5
Leg fat-free mass (left)	0.6	3.0	4.2	1.3	-2.1
Impedance of leg (left)	0.6	3.1	3.8	-1.5	1.9
Leg predicted mass (left)	0.6	3.1	4.1	1.4	-2.0
Waist circumference	0.6	2.2	4.2	0.4	-2.1
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.2	0.6	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	1.5	1.2	0.6
Lung cancer (father)	0.6	0.7	1.3	-1.2	-0.1
Exposure to tobacco smoke at home	0.6	0.7	0.8	-0.7	0.9
Headache pain in last month	0.6	1.1	2.1	1.4	-0.3
Arm fat-free mass (right)	0.6	2.9	3.5	1.5	-1.9
Pulse wave peak to peak time	0.6	0.7	1.0	-1.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	0.9	-0.7	-0.9
Commuting to job workplace: Walk	0.6	0.6	1.1	0.3	1.1
Mineral and other dietary supplements	0.6	0.8	1.6	-0.2	-1.3
Osteoarthritis (self-reported)	0.6	0.8	1.4	0.3	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.4	1.5	-0.3
Arm fat mass (left)	0.6	2.6	3.5	1.3	-1.9
Medication: Blood pressure	0.6	1.2	1.6	1.3	-0.9
Medication: Paracetamol	0.6	0.9	1.4	-1.2	-0.7
Ever smoked	0.6	1.0	1.9	-0.3	-1.4
Leg fat percentage (left)	0.6	2.3	4.2	0.6	-2.1
Ulcerative Colitis (UC)	0.5	0.9	1.6	-0.3	1.3
Neuroticism (2016)	0.5	0.8	1.4	-0.3	-1.2
Blood Eosinophil Count	0.5	4.2	8.4	0.3	2.9
Supplements: Zinc	0.5	0.6	1.1	-1.1	0.2
High blood pressure	0.5	1.3	1.9	-0.8	-1.4
Alcohol usually taken with meals	0.5	0.9	1.0	1.0	0.9
Hair/balding pattern: Pattern 2	0.5	0.6	0.9	0.9	0.6
Father’s age at death	0.5	0.7	1.4	1.2	0.2
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	0.2	-1.2
Glaucoma (self-reported)	0.5	0.6	0.9	0.5	1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.1	-0.3	-1.1
Illnesses of father: Heart disease	0.5	0.7	0.9	1.0	0.7
Ever taken oral contraceptive pill	0.5	0.6	1.0	1.0	-0.4
Hearing aid user	0.5	0.5	1.0	-1.0	0.3
Irritability	0.5	0.8	0.9	0.9	0.8
Pack years of smoking	0.5	0.7	1.3	-1.2	0.3
Impedance of whole body	0.5	2.4	4.1	-0.8	2.0
HbA1C	0.4	0.4	0.6	0.8	-0.5
Ulcerative Colitis	0.4	0.5	0.7	0.6	0.8
Hand grip strength (left)	0.4	1.0	1.6	-1.3	-0.5
Frequency of depressed mood in last 2 weeks	0.4	0.5	0.9	0.3	-0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	0.7	0.6	0.9
Supplements: Glucosamine	0.4	0.6	0.9	-0.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.4	0.0	1.2
Illnesses of siblings	0.4	0.5	0.8	-0.5	-0.9
Falls in the last year	0.4	0.6	0.9	0.9	-0.5
Pulse rate	0.4	0.7	1.3	-1.2	0.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	1.6	1.3	0.6
Shortness of breath walking on level ground	0.4	0.5	0.8	0.9	0.3
Medication: Seretide 50 evohaler	0.4	0.4	0.8	-0.1	-0.9
Arm predicted mass (right)	0.4	2.2	2.9	1.2	-1.7
Number of full sisters	0.4	0.5	1.0	0.1	-1.0
Hypertension (Self-reported)	0.4	1.0	1.8	-0.6	-1.3
Whole body fat-free mass	0.4	2.2	2.9	1.2	-1.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.6	0.5	-0.8
Ever had bowel cancer screening	0.4	0.5	1.0	1.0	0.1
Medication for cholesterol	0.4	0.7	1.2	-1.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	0.9	1.0	0.0
Whole body water mass	0.4	2.3	3.2	1.2	-1.8
Medication: Bendroflumethiazide	0.4	0.7	1.1	1.1	0.5
Basal metabolic rate	0.4	2.2	3.1	1.1	-1.8
Arm fat-free mass (left)	0.4	1.9	2.7	1.1	-1.6
Average weekly beer plus cider intake	0.4	0.6	0.9	0.9	0.6
Diastolic blood pressure, automated reading	0.4	1.2	2.0	-1.4	-0.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.9	-0.6
Arm predicted mass (left)	0.4	1.8	2.0	1.2	-1.4
Lupus	0.3	0.5	0.7	0.8	-0.6
Schizophrenia (2014)	0.3	0.6	1.1	-0.4	1.0
Blood Red Count	0.3	2.5	5.0	0.1	2.2
Allergy or Eczema	0.3	0.7	1.2	-0.5	1.1
Chronotype (morning person)	0.3	0.8	1.6	-1.3	-0.1
Tanning	0.3	4.2	8.5	2.9	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	0.7	-0.3
Qualifications: CSEs or equivalent	0.3	0.4	0.9	-0.9	0.0
Hearing difficulty/problems with background noise	0.3	0.5	1.0	1.0	-0.1
Impedance of arm (right)	0.3	1.6	1.6	-1.3	1.3
Medication: Cholesterol lowering	0.3	0.4	0.5	0.6	0.7
Illnesses of mother	0.3	0.3	0.3	-0.5	-0.6
Impedance of arm (left)	0.3	1.3	2.3	-0.4	1.5
Peak expiratory flow (PEF)	0.3	0.7	0.7	-0.8	-0.8
Loud music exposure frequency	0.3	0.3	0.6	0.8	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.1	0.0	1.0
Medication: Amlodipine	0.3	0.4	0.8	-0.9	-0.2
Birth weight	0.3	0.6	0.7	0.8	0.8
Leg fat percentage (right)	0.3	1.3	2.3	0.4	-1.5
Comparative body size at age 10	0.3	0.9	1.6	-0.5	-1.2
Health satisfaction	0.3	0.4	0.5	0.6	0.7
Qualifications: College or University degree	0.3	0.9	1.2	1.1	0.8
Medication: Blood pressure	0.3	0.5	0.9	0.9	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.4	-0.1	1.2
Loneliness, isolation	0.3	0.4	0.7	-0.3	-0.9
Guilty feelings	0.3	0.5	0.6	0.8	-0.6
Schizophrenia (2018)	0.2	0.3	0.4	0.5	0.6
Ovarian Cancer	0.2	0.2	0.3	0.3	0.6
HDL Cholesterol	0.2	0.3	0.7	-0.1	0.8
Cardiovascular Disease	0.2	0.7	1.3	-0.4	-1.1
Hypothyroidism (self reported)	0.2	0.4	0.8	-0.9	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.5	0.7	-0.8	0.5
Sensitivity / hurt feelings	0.2	0.4	0.6	-0.8	0.4
Systolic blood pressure, automated reading	0.2	0.7	1.0	-1.0	-0.6
Diabetes (father)	0.2	0.3	0.6	0.1	-0.8
Diabetes (mother)	0.2	0.2	0.4	0.2	0.6
Hand grip strength (right)	0.2	0.5	0.9	-0.9	0.4
Townsend deprivation index at recruitment	0.2	0.3	0.4	0.6	-0.4
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.0	0.8
Sitting height	0.2	1.5	2.2	0.9	-1.5
Nervous feelings	0.2	0.5	0.7	-0.5	-0.8
Heart attack	0.2	0.3	0.5	0.7	-0.3
Allergy	0.2	0.4	0.5	0.5	-0.7
Trunk fat-free mass	0.2	1.2	1.2	1.1	-1.1
Time employed in main current job	0.2	0.3	0.3	-0.5	0.5
Noisy workplace	0.2	0.3	0.3	0.5	0.6
Prospective memory result	0.2	0.2	0.4	0.1	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.1	1.1	-0.1
Trunk predicted mass	0.2	1.1	1.2	1.1	-1.1
Tense / ‘highly strung’	0.2	0.3	0.5	0.3	0.7
Birth weight of first child	0.2	0.3	0.5	0.4	-0.7
Medication: Paracetamol	0.2	0.3	0.5	-0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.8	-0.0
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.3	-0.4	0.5
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	0.3	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.6	0.8	0.6	0.9
Exposure to tobacco smoke outside home	0.2	0.2	0.3	-0.3	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.4	0.5	-0.7	-0.6
Mean time to correctly identify matches	0.2	0.4	0.9	0.9	0.1
Suffer from ‘nerves’	0.2	0.3	0.4	0.6	0.4
Mood swings	0.2	0.4	0.8	0.9	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	-0.2	0.5
Medication: Gliclazide	0.2	0.2	0.4	-0.6	0.3
Smoking status: Current	0.2	0.3	0.3	0.5	-0.5
Myopia	0.2	0.3	0.5	-0.7	0.1
Cholesterol lowering medication	0.2	0.3	0.4	0.4	-0.7
Basal cell carcinoma (self-reported)	0.2	0.3	0.5	-0.7	-0.2
Depression (Nagel 2018)	0.1	0.1	0.2	-0.1	-0.5
Neuroticism (Nagel 2018)	0.1	0.3	0.5	-0.7	0.4
Worry (Nagel 2018)	0.1	0.3	0.5	-0.7	0.1
Irritable Bowel Disease (IBD)	0.1	0.2	0.2	-0.4	-0.4
Breast Cancer	0.1	0.3	0.6	0.0	-0.8
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.3	-0.4
Mean Putamen Volume	0.1	0.1	0.3	-0.5	0.1
Triglycerides	0.1	0.2	0.3	0.0	0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	0.5	-0.3
Blood White Count	0.1	0.8	1.5	-1.2	0.3
Height	0.1	1.3	1.4	1.2	1.1
Systolic Blood Pressure	0.1	0.3	0.6	-0.8	0.0
Smoking Status	0.1	0.2	0.4	0.1	-0.6
Respiratory disease	0.1	0.1	0.2	0.3	0.4
Lung FVC	0.1	0.7	1.3	1.1	0.4
Neuroticism	0.1	0.1	0.3	-0.1	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	-0.0
Angina	0.1	0.2	0.4	-0.1	0.6
Current tobacco smoking	0.1	0.1	0.2	0.4	-0.3
Average weekly fortified wine intake	0.1	0.1	0.1	0.4	0.3
Maternal smoking around birth	0.1	0.1	0.2	0.5	-0.3
Fed-up feelings	0.1	0.2	0.3	0.5	-0.3
Had menopause	0.1	0.1	0.2	0.1	0.4
Forced vital capacity (FVC)	0.1	0.3	0.4	0.5	0.6
Diabetes (self-reported)	0.1	0.1	0.1	0.3	-0.3
Medication: Simvastatin	0.1	0.1	0.2	0.4	-0.1
Fluid intelligence score	0.1	0.3	0.6	0.8	-0.0
Alcohol intake versus 10 years previously	0.1	0.2	0.2	0.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	0.7	0.8	-0.2
Happiness	0.1	0.2	0.2	-0.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.3	0.3
Asthma	0.1	0.1	0.3	0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.1	0.2	-0.4
Gout (self-reported)	0.1	0.2	0.2	0.5	-0.4
High blood pressure (siblings)	0.1	0.1	0.3	-0.1	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.0	0.5
Age at first live birth	0.1	0.2	0.4	-0.6	0.3
Emphysema/chronic bronchitis	0.1	0.1	0.1	0.4	0.2
Angina (self-reported)	0.1	0.2	0.4	-0.0	0.6
Migraine (self-reported)	0.1	0.1	0.2	-0.5	-0.2
Medication: Allopurinol	0.1	0.2	0.3	-0.6	0.0
Heart disease (mother)	0.1	0.1	0.1	0.2	-0.4
Comparative height size at age 10	0.1	0.7	1.3	-0.4	1.1
Overall health rating	0.1	0.2	0.4	0.6	-0.0
Illnesses of siblings: Diabetes	0.1	0.2	0.2	-0.5	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	-0.5	0.1
Miserableness	0.1	0.2	0.4	0.6	-0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	0.4
High cholesterol (Self-reported)	0.1	0.3	0.5	-0.3	-0.7
Risk taking	0.1	0.1	0.2	0.5	0.2
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.5	-0.1
Supplements: Calcium	0.1	0.1	0.1	0.1	-0.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.1	0.3
Reaction Time	0.0	0.0	0.0	0.2	0.1
Fasting Glucose	0.0	0.0	0.0	-0.1	0.2
LDL Cholesterol	0.0	0.1	0.1	-0.1	0.3
Hair Pigment	0.0	0.6	1.1	0.2	1.0
Medication: Metformin	0.0	0.0	0.0	0.0	0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.1	-0.3
High blood pressure (mother)	0.0	0.0	0.0	-0.0	0.2
Qualifications: None of the above	0.0	0.1	0.1	-0.3	-0.0
Neuroticism score	0.0	0.1	0.1	0.1	0.3
Standing height	0.0	0.3	0.5	0.5	0.7
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.2	0.3
Alcohol intake frequency.	0.0	0.0	0.0	0.0	0.0
Chest pain or discomfort	0.0	0.0	0.0	-0.2	0.2
Age at last live birth	0.0	0.1	0.1	-0.3	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	-0.2	0.1
Diabetes diagnosed by doctor	0.0	0.0	0.0	-0.1	0.2
Asthma (self-reported)	0.0	0.1	0.1	0.3	-0.3
Commuting to job workplace: Public transport	0.0	0.0	0.0	0.1	-0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.1	-0.1
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.0	0.3

Hub : Genes

MPEG1

Models

Trait associations