Hub : Genes

MPHOSPH10

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.3750 0.0390 0.0e+00 0.419 0.331 0.418 0.407 0.419 3.0e-55 2.0e-41 4.6e-55 3.5e-53 2.5e-55
2 GTEx Artery Aorta 0.2030 0.0690 2.3e-03 0.016 NA 0.055 NA 0.035 4.3e-02 NA 5.7e-04 NA 5.1e-03
3 GTEx Testis 0.2970 0.0790 2.1e-04 0.158 NA 0.096 NA 0.148 1.6e-07 NA 5.1e-05 NA 4.1e-07
4 ROSMAP Brain Pre-frontal Cortex 0.0923 0.0271 8.0e-07 0.078 0.047 0.069 0.062 0.070 2.9e-10 1.1e-06 3.4e-09 2.1e-08 2.2e-09

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.2 0.3 0.8 0.1 -0.3 -0.6 0.9
Bipolar Disorder or Schizophrenia 0.2 0.6 2.1 -0.3 -1.4 0.2 -0.0
Depressed Affect (Nagel 2018) 0.9 1.9 3.9 -1.8 0.5 2.0 0.4
Depression (Nagel 2018) 0.2 0.3 0.5 -0.7 0.1 0.7 0.5
Intelligence (Savage-Jansen 2018) 1.2 3.7 9.1 0.4 2.2 -0.9 3.0
Neuroticism (Nagel 2018) 1.6 3.9 8.5 -2.5 0.9 2.9 0.2
Schizophrenia (2018) 0.5 1.0 2.6 -0.6 -1.6 0.7 -0.7
Schizophrenia vs Biploar Disorder 2.4 3.1 7.0 1.8 -0.8 -1.3 -2.6
Worry (Nagel 2018) 0.2 0.5 1.2 -0.7 0.3 1.1 -0.5
Alzheimer’s Disease (in mother) 4.3 5.1 7.9 -2.3 -2.8 2.1 1.5
Alzheimer’s Disease (in father) 1.5 1.6 2.6 1.6 -0.8 -1.4 -1.0
Alzheimer’s Disease (including proxy) 2.2 3.2 9.7 -1.0 -3.1 1.3 -0.8
Crohns Disease (2017) 0.1 0.3 0.9 -0.1 0.5 0.1 0.9
Irritable Bowel Disease (IBD) 0.2 0.5 0.7 0.6 0.8 -0.7 0.8
Ulcerative Colitis (UC) 0.5 1.0 1.6 1.2 0.9 -1.2 0.2
Major Depression (MDD) 0.7 0.8 2.8 0.1 1.7 0.3 -0.6
Reaction Time 2.7 5.1 7.4 -2.7 -2.4 2.7 0.3
Verbal and Numeric Reasoning (VNR) 0.5 1.3 4.8 -0.5 -0.3 0.3 2.2
Breast Cancer 0.3 0.7 2.2 0.3 1.5 -0.3 -0.8
Ovarian Cancer 0.7 0.9 3.6 -0.1 -1.9 0.2 0.0
Prostate Cancer 0.1 0.1 0.2 0.3 -0.1 -0.5 0.3
Age at First Birth 0.6 0.8 1.7 1.2 -0.1 -1.3 0.0
Bipolar Disorder (2011) 0.9 0.8 1.8 0.8 -0.5 -1.4 0.8
Body Mass Index (BMI) (2010) 0.5 0.7 1.7 -0.9 -0.3 0.6 1.3
Coronary Artery Disease (CAD) 2.2 2.6 5.5 -1.7 -0.5 1.2 2.3
Crohns Disease (2012) 1.2 2.0 2.7 1.5 1.5 -1.6 0.6
Mean Putamen Volume 0.1 0.1 0.3 0.1 -0.4 0.1 -0.6
Fasting Glucose 0.3 0.4 1.1 -0.7 -0.2 1.0 -0.2
HbA1C 0.8 0.9 1.5 -1.2 0.7 1.1 0.8
HDL Cholesterol 2.0 3.3 7.6 2.3 -0.3 -2.8 0.2
LDL Cholesterol 0.4 0.7 2.3 -0.3 0.3 -0.3 1.5
Lupus 0.3 0.5 0.7 0.7 0.8 -0.8 0.4
Neuroticism (2016) 1.5 2.2 4.2 -1.3 1.3 2.1 -1.1
Primary Biliary Cirrhosis 1.2 1.7 2.5 1.6 0.8 -1.3 -1.5
Rheumatoid Arthritis 1.7 2.4 4.9 2.2 0.7 -1.9 -0.7
Schizophrenia (2014) 0.4 0.9 2.4 0.8 -0.6 -0.5 -1.6
Triglycerides 1.0 1.6 3.1 -1.4 -0.1 1.2 1.8
Type 2 Diabetes (T2D) (2012) 1.1 1.3 3.4 1.2 -0.4 -1.8 0.4
Ulcerative Colitis 0.8 1.2 2.6 1.4 0.0 -1.6 0.7
Blood Eosinophil Count 1.7 13.2 18.3 -4.3 -1.4 4.3 3.8
Blood Platelet Count 0.1 1.3 3.6 0.7 -1.1 -0.2 -1.9
Blood Red Count 0.0 0.2 0.6 0.4 -0.8 -0.3 -0.0
Blood White Count 0.3 2.1 4.4 -1.9 0.3 2.1 0.6
Heel T-Score 0.7 5.8 14.1 0.3 3.8 -1.6 2.5
BMI 0.1 0.7 1.1 -1.1 0.1 1.1 0.7
Height 0.7 12.9 30.7 1.3 -4.4 -0.0 -5.5
Waist Hip Ratio (WHR) 0.3 1.2 2.3 -0.7 -1.5 0.4 1.3
Systolic Blood Pressure 0.7 3.6 13.9 -0.0 -3.7 0.2 -0.7
Smoking Status 0.3 0.7 1.3 -1.1 0.4 1.0 0.7
Allergy or Eczema 0.4 1.0 3.3 -0.6 1.8 0.6 0.2
Cardiovascular Disease 0.5 1.6 2.7 -1.3 -1.6 1.2 0.7
Hypothyroidism (self reported) 0.6 1.5 2.2 1.5 -0.2 -1.3 -1.4
Respiratory disease 0.5 1.0 1.7 -1.3 0.1 1.2 1.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.6 -0.6 -0.6 0.8 -0.1
Lung FEV1/FVC ratio 0.1 0.7 1.1 -1.0 -0.7 1.1 0.5
Lung FVC 0.4 1.9 3.1 1.5 1.8 -1.5 -0.1
Neuroticism 0.7 1.7 4.0 -1.6 -0.5 2.0 -0.1
Chronotype (morning person) 0.4 0.9 3.6 0.1 0.3 0.4 -1.9
Hair Pigment 0.0 0.5 0.7 0.8 -0.8 -0.8 -0.4
Tanning 0.0 0.3 1.1 0.0 1.1 -0.1 0.1
Hand grip strength (left) 0.3 0.8 1.7 0.7 -1.3 -0.7 -0.7
Number of treatments/medications taken 1.1 2.0 2.8 -1.7 -1.4 1.6 0.8
Average weekly spirits intake 2.9 3.6 6.6 -2.5 -1.2 2.6 0.1
Sensitivity / hurt feelings 1.0 1.7 4.0 -1.4 0.5 2.0 -0.8
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.1 -0.8 0.4 1.1 -0.1
Hearing difficulty/problems: Yes 0.4 0.6 1.4 1.0 -0.2 -1.2 -0.1
Relative age of first facial hair 0.1 0.2 0.4 0.4 0.6 -0.2 0.6
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 1.9 0.8 0.9 -0.6 -1.4
Ever used hormone-replacement therapy (HRT) 1.7 2.2 4.7 -1.1 1.6 0.4 2.2
Ever had hysterectomy (womb removed) 0.1 0.1 0.3 -0.4 -0.0 0.3 0.6
Systolic blood pressure, automated reading 0.4 1.1 2.4 1.0 -1.5 -1.0 -0.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.4 -0.4 -1.2 0.7 -0.8
Angina 0.6 0.8 1.6 -0.0 1.1 -0.5 1.3
Medication for hormone replacement therapy 1.4 1.6 4.9 -1.1 0.2 0.3 2.2
Vitamin and mineral supplements 0.1 0.2 0.4 0.2 0.6 -0.5 0.4
Supplements: Zinc 1.1 1.2 2.7 -0.5 -1.6 1.1 -0.8
Medication: Co-codamol 0.6 0.7 1.3 1.1 -0.0 -1.0 -0.8
Medication: Metformin 0.8 1.2 2.0 -0.8 -1.4 1.2 -0.6
Diabetes (father) 0.1 0.2 0.4 -0.3 -0.4 0.6 -0.1
Diabetes (mother) 0.3 0.3 0.7 0.3 -0.8 -0.6 0.4
Severe depression (siblings) 0.2 0.2 0.5 -0.1 0.6 -0.0 0.7
Pack years adult smoking proportion 0.8 1.2 4.5 -0.0 -2.1 -0.1 0.3
Impedance of leg (right) 0.2 1.0 2.2 0.9 0.8 -1.5 0.7
Leg fat-free mass (left) 0.6 3.4 4.8 -1.1 -1.8 2.1 -2.2
Trunk fat percentage 0.2 0.8 1.8 -1.0 -0.2 0.7 1.3
Hand grip strength (right) 0.3 0.9 2.9 0.5 -1.7 -0.6 -0.5
Townsend deprivation index at recruitment 0.9 1.3 2.1 -1.4 -0.4 1.5 1.0
Current tobacco smoking 0.4 0.7 2.4 -0.5 -0.5 -0.1 1.5
Average weekly fortified wine intake 1.9 2.2 4.0 2.0 1.0 -1.5 -1.3
Maternal smoking around birth 0.3 0.4 1.2 -0.1 -1.1 0.3 -0.7
Fed-up feelings 0.4 0.6 1.7 -0.9 -0.0 1.3 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.5 -0.6 -0.6 0.7 0.1
Relative age voice broke 0.1 0.2 0.5 0.3 0.1 0.0 -0.7
Taking other prescription medications 0.0 0.0 0.0 -0.0 -0.1 0.1 -0.1
Age when periods started (menarche) 0.4 0.9 1.4 -1.2 -0.8 1.1 -0.5
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.3 -0.6 1.2 0.6 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.4 0.5 0.7 -0.6 -0.0
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 3.1 1.4 1.2 -1.8 -0.1
Qualifications: CSEs or equivalent 0.4 0.6 1.8 -0.3 -0.0 0.6 -1.4
Serious illness, injury or assault to yourself 0.3 0.3 0.6 0.5 0.8 -0.6 -0.3
High blood pressure 0.6 1.8 5.3 -1.1 -2.3 0.8 0.5
Hayfever, allergic rhinitis or eczema 0.8 1.8 5.5 -0.6 2.3 0.3 1.1
Multivitamins +/- minerals 0.0 0.0 0.1 0.1 0.3 -0.2 0.3
Stomach or abdominal pain in last month 0.1 0.2 0.3 -0.2 0.5 0.6 -0.3
Supplements: Glucosamine 0.2 0.3 0.7 0.2 -0.6 -0.1 -0.8
Diverticular disease/diverticulitis (self-reported) 1.5 1.7 5.4 -0.9 0.8 0.2 2.3
Medication: Atenolol 0.6 0.8 2.2 -0.1 0.9 -0.0 1.5
Medication: Levothyroxine sodium 0.6 1.1 2.5 1.0 -0.6 -0.7 -1.6
Sitting height 0.7 4.9 10.2 -0.5 -3.2 1.2 -2.8
Chronic bronchitis/emphysema (father) 1.5 1.7 4.9 -0.7 -1.2 0.2 2.2
High blood pressure (mother) 0.3 0.4 1.3 -0.4 -0.2 -0.1 1.1
Body mass index (BMI) 0.3 1.3 2.2 -1.5 0.2 1.5 0.8
Impedance of leg (left) 0.2 0.9 2.3 0.9 -0.1 -1.5 0.7
Leg predicted mass (left) 0.7 3.6 4.9 -1.2 -1.9 2.2 -2.2
Trunk fat mass 0.2 0.7 1.0 -1.0 -0.8 1.0 0.5
Waist circumference 0.3 1.1 1.9 -1.3 -0.9 1.4 0.1
Number of incorrect matches in round 0.7 1.2 2.2 -0.7 -0.0 1.5 -1.4
Past tobacco smoking 0.9 1.6 3.8 1.6 -0.2 -2.0 0.1
Alcohol usually taken with meals 1.9 3.1 5.7 2.3 1.1 -2.4 -0.2
Nervous feelings 0.5 0.9 1.3 -1.0 1.2 1.1 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 3.0 -0.2 1.7 0.3 -0.2
Hearing difficulty/problems with background noise 0.1 0.1 0.2 -0.3 -0.5 0.1 -0.3
Hair/balding pattern: Pattern 2 1.3 1.6 4.7 -0.5 2.2 0.2 1.1
Had menopause 1.2 1.5 2.8 1.6 0.5 -1.7 -0.5
Had other major operations 0.3 0.4 1.0 0.8 -0.2 -1.0 0.1
Forced vital capacity (FVC) 0.0 0.2 0.6 0.3 0.8 -0.2 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.6 0.9 0.6 -1.3 0.2
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 1.7 -1.3 -0.5 1.2 1.0
Qualifications: None of the above 2.3 4.9 9.3 -2.8 -1.4 3.0 0.6
Financial difficulties in last 2 years 0.4 0.5 0.8 -0.3 -0.8 0.6 -0.9
Mouth/teeth dental problems 0.7 1.1 2.0 0.9 1.2 -1.4 0.4
Heart attack 0.4 0.5 1.3 0.3 -0.5 -0.7 1.1
Allergy 0.6 1.3 3.7 0.7 -1.9 -0.5 -0.8
Pain all over the body in last month 0.8 0.9 3.4 0.3 -1.9 -0.2 0.1
Diabetes (self-reported) 0.3 0.5 1.4 0.0 -1.2 0.3 -0.7
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.5 -1.0 1.2 0.8 0.8
Medication: Ramipril 2.3 2.9 10.4 -0.8 -3.2 0.5 0.5
Medication: Simvastatin 0.1 0.2 0.3 0.5 0.1 -0.6 0.5
Fluid intelligence score 0.9 1.8 5.1 -1.0 0.8 0.7 2.2
Illnesses of siblings 1.4 2.0 7.0 0.0 -0.8 0.5 -2.6
Neuroticism score 0.6 1.2 2.9 -1.2 -0.1 1.7 -0.6
Weight 0.3 1.5 2.2 -0.9 -1.1 1.5 -1.3
Impedance of arm (right) 0.1 0.5 1.0 0.5 0.4 -0.8 1.0
Arm fat percentage (right) 0.5 1.9 3.1 -1.6 0.3 1.4 1.8
Trunk fat-free mass 0.7 4.1 9.1 -0.4 -2.3 1.3 -3.0
Hip circumference 0.3 1.3 2.6 -1.1 -0.6 1.6 -1.1
Time employed in main current job 1.2 1.3 3.1 1.1 -1.8 -0.8 -0.7
Alcohol intake versus 10 years previously 0.4 0.6 1.2 -0.7 0.6 1.1 -0.6
Father’s age at death 0.3 0.4 1.4 0.3 -0.0 0.1 -1.2
Worrier / anxious feelings 1.0 2.0 3.4 -1.0 0.7 1.8 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.7 0.6 0.3 -0.3 -0.9
Falls in the last year 0.4 0.6 1.2 -0.5 -1.1 0.5 -0.7
Hair/balding pattern: Pattern 3 0.9 1.4 3.7 -0.9 -1.9 1.0 -0.1
Number of live births 0.1 0.2 0.5 0.4 0.0 -0.7 0.2
Forced expiratory volume in 1-second (FEV1) 0.0 0.1 0.3 -0.1 0.5 0.3 0.1
Pulse rate 0.7 1.2 3.2 -0.9 -1.8 0.5 0.6
Happiness 3.2 3.9 8.6 -2.5 -0.7 2.9 0.4
Noisy workplace 0.2 0.3 0.4 -0.6 -0.7 0.6 -0.3
Qualifications: A levels/AS levels or equivalent 1.2 2.6 6.8 0.9 0.7 -1.6 2.6
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 2.7 -0.9 -0.7 1.6 -1.2
Mouth/teeth dental problems: Dentures 1.4 2.3 4.9 -1.9 -0.5 2.2 0.9
Asthma 0.1 0.2 0.2 -0.4 0.3 0.5 0.5
Medication: Ibuprofen (e.g. Nurofen) 4.1 5.2 9.0 -3.0 0.5 2.8 1.9
Medication: Cholesterol lowering 0.2 0.4 1.0 0.1 -0.5 -0.4 1.0
Depression (self-reported) 0.1 0.2 0.3 -0.1 0.5 0.2 -0.6
Medication: Lansoprazole 0.2 0.2 0.5 0.6 0.4 -0.7 -0.3
Prospective memory result 1.4 1.7 3.8 1.2 -0.1 -1.3 -1.9
Lung cancer (father) 0.3 0.4 0.6 0.6 -0.7 -0.8 -0.5
Illnesses of mother 0.7 0.9 1.8 -1.1 0.7 1.3 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.7 -0.1 -0.8 0.5 -0.7
Pulse wave Arterial Stiffness index 2.4 2.8 6.3 -2.0 -0.4 2.5 -0.8
Impedance of arm (left) 0.3 1.5 2.1 1.1 1.4 -1.4 0.7
Arm fat mass (right) 0.3 1.1 2.3 -1.4 -0.2 1.5 0.4
Trunk predicted mass 0.7 4.1 9.7 -0.4 -2.2 1.3 -3.1
Standing height 0.8 7.6 21.0 1.2 -2.8 0.0 -4.6
Length of working week for main job 3.4 3.8 6.0 -2.4 -1.3 2.4 1.3
Exposure to tobacco smoke at home 1.8 2.0 4.1 -1.3 -2.0 0.9 1.2
Breastfed as a baby 0.9 1.2 2.3 -1.5 -0.5 1.5 -0.0
Tense / ‘highly strung’ 1.0 1.6 2.8 -1.7 0.5 1.7 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.8 -0.8 1.4 0.6 0.9
Hair/balding pattern: Pattern 4 1.3 3.3 7.0 -2.4 -0.3 2.6 0.6
Birth weight of first child 0.9 1.7 3.3 1.0 1.8 -1.5 0.3
Peak expiratory flow (PEF) 0.1 0.3 0.8 0.6 -0.2 -0.2 -0.9
Pulse wave reflection index 0.6 0.8 1.2 -0.8 1.1 1.1 -0.1
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.7 -0.1 0.2 0.6 -1.3
Loud music exposure frequency 4.7 5.1 11.5 2.0 1.9 -1.1 -3.4
Qualifications: O levels/GCSEs or equivalent 1.6 2.5 4.5 1.9 0.8 -2.1 1.2
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 -0.4 -1.4 0.8 -0.5
Blood clot in the leg (DVT) 1.3 1.7 2.9 -1.7 -0.6 1.7 0.8
Medication: Paracetamol 0.6 1.1 3.1 -0.5 1.8 0.8 -0.6
Headache pain in last month 0.5 0.9 1.9 -1.3 0.1 1.4 -0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 0.4 0.5 -0.2 -0.7
Glaucoma (self-reported) 0.4 0.4 1.6 0.0 -1.3 -0.4 0.1
Gout (self-reported) 1.7 2.3 3.6 -1.9 1.3 1.7 1.0
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 1.5 1.1 -0.1 -1.0 -1.2
Medication: Amlodipine 1.2 1.7 3.0 -1.7 -0.8 1.7 0.6
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.5 -0.0 0.4 0.6 -0.7
Birth weight 1.2 2.5 3.6 1.9 1.4 -1.8 -1.1
Chronic bronchitis/emphysema (mother) 0.8 1.0 1.4 1.2 0.7 -0.9 -1.1
High blood pressure (siblings) 0.4 0.5 1.7 -0.2 0.6 0.0 1.3
Forced vital capacity (FVC), Best measure 0.2 0.7 1.5 0.9 -0.6 -0.4 -1.2
Body fat percentage 0.3 1.3 2.8 -1.2 0.1 0.9 1.7
Leg fat percentage (right) 0.4 1.3 2.7 -1.1 0.9 0.7 1.6
Arm fat-free mass (right) 0.5 2.7 6.9 -0.3 -1.6 1.1 -2.6
Exposure to tobacco smoke outside home 0.5 0.7 1.0 0.7 1.0 -1.0 -0.3
Comparative body size at age 10 0.4 1.1 2.3 -0.1 1.5 -0.3 1.4
Number of full brothers 0.8 1.0 3.4 -0.2 0.6 -0.5 1.9
Worry too long after embarrassment 1.1 1.8 4.0 -1.7 0.5 2.0 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.4 -0.0 0.5 -0.2 1.2
Wheeze or whistling in the chest in last year 0.1 0.2 0.9 0.2 0.1 0.1 -0.9
Number of children fathered 0.6 0.7 2.0 -0.4 0.8 0.1 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.5 -0.3 0.4 0.9 -1.2
Age at first live birth 0.0 0.1 0.2 0.1 0.4 -0.1 -0.4
Pulse wave peak to peak time 2.4 2.9 6.6 2.2 0.3 -2.6 0.3
Health satisfaction 0.3 0.4 1.1 -0.3 1.0 0.5 0.2
Shortness of breath walking on level ground 1.9 2.2 3.9 -2.0 -1.2 1.7 0.8
Qualifications: College or University degree 0.2 0.6 1.7 0.3 -0.1 -0.8 1.3
Eye problems/disorders: None of the above 1.7 1.9 4.0 -1.5 0.6 1.1 2.0
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.7 -0.2 0.7 -0.1
Emphysema/chronic bronchitis 0.5 0.6 0.8 0.7 0.9 -0.6 -0.7
Medication for pain relief, constipation, heartburn 1.1 1.9 2.8 1.7 -0.3 -1.6 -1.5
Neck or shoulder pain in last month 1.7 2.4 9.0 0.2 -3.0 -0.2 -0.8
Medication: Blood pressure 0.6 1.0 1.6 -1.0 -1.1 1.3 -0.3
Angina (self-reported) 0.4 0.5 1.1 -0.1 0.9 -0.3 1.1
Migraine (self-reported) 2.1 2.6 4.5 1.6 1.8 -2.1 0.3
Medication: Ibuprofen 4.6 5.5 9.8 -3.1 0.3 3.1 1.6
Medication: Allopurinol 2.2 2.9 5.5 -1.8 1.1 1.3 2.4
Medication: Omeprazole 0.7 0.8 1.4 -0.6 -1.2 1.1 -0.6
Medication: Seretide 50 evohaler 0.3 0.3 0.5 0.4 0.7 -0.6 0.5
Mean time to correctly identify matches 2.7 5.1 7.6 -2.8 -2.2 2.5 1.3
Heart disease (mother) 0.8 1.0 1.8 -0.8 -1.1 0.6 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.4 3.4 -1.4 0.3 1.8 -0.4
Whole body fat mass 0.3 1.1 2.0 -1.3 -0.6 1.4 0.4
Leg fat mass (right) 0.3 1.2 2.3 -1.4 -0.3 1.5 0.4
Arm predicted mass (right) 0.6 3.1 7.0 -0.3 -2.0 1.2 -2.6
Pulse rate, automated reading 1.0 3.3 8.2 -1.6 -2.9 1.4 0.8
Alcohol intake frequency. 0.1 0.2 0.4 -0.6 -0.2 0.6 0.2
Comparative height size at age 10 1.1 5.9 12.6 2.1 -2.1 -1.4 -3.5
Number of full sisters 0.4 0.5 0.7 -0.8 0.8 0.8 -0.3
Suffer from ‘nerves’ 0.2 0.2 0.7 -0.2 -0.9 0.4 -0.2
Overall health rating 0.8 1.7 3.0 -1.7 -0.7 1.7 0.7
Chest pain or discomfort 0.4 0.6 1.8 -0.4 0.5 -0.3 1.3
Had major operations 0.3 0.3 1.0 -0.2 1.0 -0.1 0.4
Age at last live birth 0.6 0.9 1.5 -1.2 0.3 1.1 0.9
Family relationship satisfaction 0.5 0.6 1.7 0.4 -0.6 0.2 -1.3
Leg pain on walking 2.3 2.9 5.8 -1.8 -1.3 2.4 -0.8
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 6.4 0.3 1.0 0.6 -2.5
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.8 -0.7 -0.8 0.9 -0.3
Illness, injury, bereavement, stress in last 2 years 1.6 2.0 6.4 -1.0 -0.6 0.2 2.5
Medication: Aspirin 0.3 0.4 1.4 0.2 -0.2 -0.5 1.2
Supplements: Vitamin C 0.6 0.7 1.8 0.1 0.9 0.5 -1.4
Knee pain experienced in last month 0.1 0.2 0.5 -0.7 -0.0 0.6 0.2
Hypertension (Self-reported) 0.7 1.9 5.1 -1.2 -2.3 1.0 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.4 -0.7 -0.1 1.2 -0.5
Illnesses of father: Heart disease 1.0 1.4 3.0 -0.7 -1.7 0.3 1.4
Illnesses of siblings: Diabetes 1.0 1.3 3.8 -0.7 -0.7 0.5 1.9
Smoking status: Previous 0.7 1.1 2.7 -1.2 0.0 1.7 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.6 3.2 8.8 1.8 -0.1 -1.0 -3.0
Whole body fat-free mass 0.7 4.2 8.0 -0.7 -2.3 1.7 -2.8
Leg fat-free mass (right) 0.7 3.8 5.6 -0.9 -2.2 1.9 -2.4
Arm fat percentage (left) 0.4 1.7 3.2 -1.3 0.8 1.0 1.8
Average weekly red wine intake 1.8 2.7 5.1 2.3 0.7 -2.1 -0.9
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.5 0.5 -0.9 -0.2 -1.2
Mood swings 1.0 1.8 3.8 -1.7 -0.5 2.0 0.1
Loneliness, isolation 0.7 0.9 2.0 -1.2 -0.2 1.4 0.4
Long-standing illness, disability or infirmity 0.1 0.1 0.4 0.2 -0.2 -0.6 -0.1
Ever had bowel cancer screening 4.1 4.8 8.0 -2.8 -1.4 2.8 1.1
Diabetes diagnosed by doctor 0.2 0.3 1.0 -0.2 -1.0 0.2 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.8 1.7 -0.7 -0.5 1.3 -1.0
Friendships satisfaction 0.9 1.1 2.8 -1.1 -0.4 1.7 -0.4
Qualifications: nursing, teaching 0.8 1.2 4.2 0.1 2.0 -0.3 0.8
Commuting to job workplace: Walk 0.3 0.3 0.6 0.8 0.5 -0.7 0.1
Eye problems/disorders: Cataract 1.8 2.1 3.6 1.8 -0.9 -1.9 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 -0.2 -0.8 0.5 -0.8
Medication for cholesterol 0.6 0.9 2.5 0.1 0.9 0.5 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.7 -0.6 0.8 0.7 0.4
Back pain experienced in last month 0.1 0.2 0.5 -0.2 -0.1 0.2 -0.7
Mineral and other dietary supplements 0.2 0.3 0.4 0.6 -0.4 -0.6 -0.4
Breast cancer (self-reported) 0.7 0.9 1.0 1.0 -0.9 -0.9 -0.9
Asthma (self-reported) 0.3 0.7 1.2 -1.1 -0.2 1.1 0.6
Osteoporosis (self-reported) 1.0 1.3 3.1 0.9 1.8 -1.1 0.1
Osteoarthritis (self-reported) 0.4 0.5 0.9 0.5 0.7 -1.0 -0.5
Medication: Aspirin 0.5 0.6 1.8 0.3 -0.0 -0.7 1.3
Medication: Gliclazide 0.2 0.2 0.4 0.3 0.4 -0.5 0.6
Illnesses of father: None of the above (group 1) 1.0 1.3 4.6 0.3 2.1 -0.2 -0.6
Smoking status: Current 0.2 0.4 1.3 -0.4 -0.0 -0.0 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 1.2 -1.1 -1.0 1.0 0.9
Whole body water mass 0.7 4.0 7.2 -0.8 -2.2 1.8 -2.7
Leg predicted mass (right) 0.7 3.7 5.2 -0.9 -2.2 1.9 -2.3
Arm fat mass (left) 0.1 0.6 1.2 -1.0 0.2 1.1 0.2
Number of self-reported non-cancer illnesses 0.9 1.5 1.9 -1.4 -1.2 1.0 1.2
Average weekly champagne plus white wine intake 1.2 1.7 5.4 0.2 2.3 -0.7 0.9
Miserableness 2.4 4.1 6.8 -2.5 1.8 2.6 0.4
Guilty feelings 1.1 1.7 2.8 -1.3 1.5 1.7 -0.2
Wears glasses or contact lenses 0.4 0.5 1.2 0.5 0.7 0.0 -1.1
Ever taken oral contraceptive pill 0.3 0.4 0.9 -0.4 -0.7 0.1 0.9
Hearing aid user 1.2 1.4 4.9 0.4 2.2 -0.6 0.2
Mother’s age at death 1.3 1.6 2.9 1.3 1.7 -1.4 0.2
Financial situation satisfaction 1.6 2.0 3.7 -1.2 -0.5 1.9 -1.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.7 -0.7 -0.6 1.3 -1.0
Commuting to job workplace: Public transport 0.5 0.6 0.8 0.9 0.7 -0.7 -0.9
Eye problems/disorders: Glaucoma 2.3 2.7 3.9 1.8 -1.4 -2.0 -1.2
Medication: Blood pressure 0.3 0.6 1.7 -0.2 -1.3 -0.2 0.9
Pain type(s) experienced in last month: Hip pain 1.6 2.0 3.2 1.5 -1.1 -1.2 -1.8
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.3 -0.5 0.5 0.5 0.2
High cholesterol (Self-reported) 0.6 1.0 1.4 -1.1 -0.9 1.2 0.8
Medication: Bendroflumethiazide 0.1 0.1 0.4 -0.1 -0.4 -0.2 0.6
Medication: Paracetamol 0.4 0.6 1.0 -0.8 0.7 1.0 -0.4
Medication: Lisinopril 0.6 0.8 2.5 0.1 -0.7 0.6 -1.6
Medication: Atorvastatin 0.8 1.0 2.2 -1.1 -0.6 0.5 1.5
Illnesses of father: High blood pressure 0.3 0.3 0.5 0.7 0.4 -0.5 -0.7
Alcohol drinker status: Never 4.1 4.9 8.1 2.7 1.2 -2.8 -1.7
Ever smoked 1.7 3.0 5.9 -2.2 -0.2 2.4 1.0
Basal metabolic rate 0.6 3.6 6.1 -0.9 -2.0 1.8 -2.5
Leg fat percentage (left) 0.3 1.0 2.7 -1.0 0.3 0.6 1.6
Arm fat-free mass (left) 0.7 3.4 7.9 -0.5 -1.9 1.4 -2.8
Number of operations (self-reported) 0.4 0.6 1.5 0.7 1.2 -0.5 -0.4
Average weekly beer plus cider intake 2.3 3.4 5.0 -2.0 -2.2 2.0 0.6
Irritability 2.7 4.6 8.1 -2.7 -0.9 2.8 1.4
Risk taking 0.8 1.1 1.6 -1.3 0.9 1.1 1.0
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 -0.1 -0.7 0.1 0.6
Fractured/broken bones in last 5 years 0.1 0.1 0.2 -0.2 -0.0 0.4 -0.5
Age started oral contraceptive pill 0.9 1.2 2.8 1.1 -0.4 -0.7 -1.7
Diastolic blood pressure, automated reading 0.7 2.0 3.2 -1.4 -1.3 1.1 1.8
Ever depressed for a whole week 0.7 0.9 3.6 -0.1 -1.9 0.0 -0.2
Unable to work because of sickness or disability 1.8 2.3 4.4 -1.8 0.1 1.3 2.1
Commuting to job workplace: Cycle 0.4 0.5 2.0 -0.3 -1.4 0.2 -0.0
Myopia 0.1 0.2 0.6 0.4 -0.8 -0.1 -0.2
Vascular/heart problems diagnosed by doctor 0.5 1.4 3.4 0.9 1.8 -0.4 -1.1
Cholesterol lowering medication 0.1 0.1 0.2 -0.2 -0.2 0.4 0.3
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 2.6 -0.6 -1.6 0.9 -0.3
Pain experienced in last month 0.5 0.9 1.8 1.1 0.7 -1.3 0.4
Supplements: Calcium 0.5 0.5 1.6 -0.2 -1.3 0.3 -0.5
Basal cell carcinoma (self-reported) 0.9 1.0 1.5 -1.2 -0.6 1.0 1.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.2 0.0 -0.6 -0.5 1.1
Deep venous thrombosis (DVT) (self-reported) 1.1 1.4 2.2 -1.5 -0.2 1.4 1.1
Heart disease (siblings) 1.0 1.2 3.8 0.3 0.3 -0.9 2.0
Alcohol drinker status: Previous 0.1 0.1 0.2 -0.3 -0.4 0.4 -0.2
Pack years of smoking 0.7 1.1 4.0 0.4 -2.0 -0.5 0.1
Impedance of whole body 0.2 1.0 2.1 1.0 0.7 -1.4 0.7
Leg fat mass (left) 0.3 1.3 2.3 -1.5 -0.7 1.5 0.5
Arm predicted mass (left) 0.8 3.9 6.6 -0.9 -2.2 1.8 -2.6