Hub : Genes

MPHOSPH10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3750	0.0390	0.0e+00	0.419	0.331	0.418	0.407	0.419	3.0e-55	2.0e-41	4.6e-55	3.5e-53	2.5e-55
2	GTEx	Artery Aorta	0.2030	0.0690	2.3e-03	0.016	NA	0.055	NA	0.035	4.3e-02	NA	5.7e-04	NA	5.1e-03
3	GTEx	Testis	0.2970	0.0790	2.1e-04	0.158	NA	0.096	NA	0.148	1.6e-07	NA	5.1e-05	NA	4.1e-07
4	ROSMAP	Brain Pre-frontal Cortex	0.0923	0.0271	8.0e-07	0.078	0.047	0.069	0.062	0.070	2.9e-10	1.1e-06	3.4e-09	2.1e-08	2.2e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.8	0.1	-0.3	-0.6	0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	2.1	-0.3	-1.4	0.2	-0.0
Depressed Affect (Nagel 2018)	0.9	1.9	3.9	-1.8	0.5	2.0	0.4
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	0.1	0.7	0.5
Intelligence (Savage-Jansen 2018)	1.2	3.7	9.1	0.4	2.2	-0.9	3.0
Neuroticism (Nagel 2018)	1.6	3.9	8.5	-2.5	0.9	2.9	0.2
Schizophrenia (2018)	0.5	1.0	2.6	-0.6	-1.6	0.7	-0.7
Schizophrenia vs Biploar Disorder	2.4	3.1	7.0	1.8	-0.8	-1.3	-2.6
Worry (Nagel 2018)	0.2	0.5	1.2	-0.7	0.3	1.1	-0.5
Alzheimer’s Disease (in mother)	4.3	5.1	7.9	-2.3	-2.8	2.1	1.5
Alzheimer’s Disease (in father)	1.5	1.6	2.6	1.6	-0.8	-1.4	-1.0
Alzheimer’s Disease (including proxy)	2.2	3.2	9.7	-1.0	-3.1	1.3	-0.8
Crohns Disease (2017)	0.1	0.3	0.9	-0.1	0.5	0.1	0.9
Irritable Bowel Disease (IBD)	0.2	0.5	0.7	0.6	0.8	-0.7	0.8
Ulcerative Colitis (UC)	0.5	1.0	1.6	1.2	0.9	-1.2	0.2
Major Depression (MDD)	0.7	0.8	2.8	0.1	1.7	0.3	-0.6
Reaction Time	2.7	5.1	7.4	-2.7	-2.4	2.7	0.3
Verbal and Numeric Reasoning (VNR)	0.5	1.3	4.8	-0.5	-0.3	0.3	2.2
Breast Cancer	0.3	0.7	2.2	0.3	1.5	-0.3	-0.8
Ovarian Cancer	0.7	0.9	3.6	-0.1	-1.9	0.2	0.0
Prostate Cancer	0.1	0.1	0.2	0.3	-0.1	-0.5	0.3
Age at First Birth	0.6	0.8	1.7	1.2	-0.1	-1.3	0.0
Bipolar Disorder (2011)	0.9	0.8	1.8	0.8	-0.5	-1.4	0.8
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	-0.9	-0.3	0.6	1.3
Coronary Artery Disease (CAD)	2.2	2.6	5.5	-1.7	-0.5	1.2	2.3
Crohns Disease (2012)	1.2	2.0	2.7	1.5	1.5	-1.6	0.6
Mean Putamen Volume	0.1	0.1	0.3	0.1	-0.4	0.1	-0.6
Fasting Glucose	0.3	0.4	1.1	-0.7	-0.2	1.0	-0.2
HbA1C	0.8	0.9	1.5	-1.2	0.7	1.1	0.8
HDL Cholesterol	2.0	3.3	7.6	2.3	-0.3	-2.8	0.2
LDL Cholesterol	0.4	0.7	2.3	-0.3	0.3	-0.3	1.5
Lupus	0.3	0.5	0.7	0.7	0.8	-0.8	0.4
Neuroticism (2016)	1.5	2.2	4.2	-1.3	1.3	2.1	-1.1
Primary Biliary Cirrhosis	1.2	1.7	2.5	1.6	0.8	-1.3	-1.5
Rheumatoid Arthritis	1.7	2.4	4.9	2.2	0.7	-1.9	-0.7
Schizophrenia (2014)	0.4	0.9	2.4	0.8	-0.6	-0.5	-1.6
Triglycerides	1.0	1.6	3.1	-1.4	-0.1	1.2	1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.4	1.2	-0.4	-1.8	0.4
Ulcerative Colitis	0.8	1.2	2.6	1.4	0.0	-1.6	0.7
Blood Eosinophil Count	1.7	13.2	18.3	-4.3	-1.4	4.3	3.8
Blood Platelet Count	0.1	1.3	3.6	0.7	-1.1	-0.2	-1.9
Blood Red Count	0.0	0.2	0.6	0.4	-0.8	-0.3	-0.0
Blood White Count	0.3	2.1	4.4	-1.9	0.3	2.1	0.6
Heel T-Score	0.7	5.8	14.1	0.3	3.8	-1.6	2.5
BMI	0.1	0.7	1.1	-1.1	0.1	1.1	0.7
Height	0.7	12.9	30.7	1.3	-4.4	-0.0	-5.5
Waist Hip Ratio (WHR)	0.3	1.2	2.3	-0.7	-1.5	0.4	1.3
Systolic Blood Pressure	0.7	3.6	13.9	-0.0	-3.7	0.2	-0.7
Smoking Status	0.3	0.7	1.3	-1.1	0.4	1.0	0.7
Allergy or Eczema	0.4	1.0	3.3	-0.6	1.8	0.6	0.2
Cardiovascular Disease	0.5	1.6	2.7	-1.3	-1.6	1.2	0.7
Hypothyroidism (self reported)	0.6	1.5	2.2	1.5	-0.2	-1.3	-1.4
Respiratory disease	0.5	1.0	1.7	-1.3	0.1	1.2	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	-0.6	-0.6	0.8	-0.1
Lung FEV1/FVC ratio	0.1	0.7	1.1	-1.0	-0.7	1.1	0.5
Lung FVC	0.4	1.9	3.1	1.5	1.8	-1.5	-0.1
Neuroticism	0.7	1.7	4.0	-1.6	-0.5	2.0	-0.1
Chronotype (morning person)	0.4	0.9	3.6	0.1	0.3	0.4	-1.9
Hair Pigment	0.0	0.5	0.7	0.8	-0.8	-0.8	-0.4
Tanning	0.0	0.3	1.1	0.0	1.1	-0.1	0.1
Hand grip strength (left)	0.3	0.8	1.7	0.7	-1.3	-0.7	-0.7
Number of treatments/medications taken	1.1	2.0	2.8	-1.7	-1.4	1.6	0.8
Average weekly spirits intake	2.9	3.6	6.6	-2.5	-1.2	2.6	0.1
Sensitivity / hurt feelings	1.0	1.7	4.0	-1.4	0.5	2.0	-0.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.1	-0.8	0.4	1.1	-0.1
Hearing difficulty/problems: Yes	0.4	0.6	1.4	1.0	-0.2	-1.2	-0.1
Relative age of first facial hair	0.1	0.2	0.4	0.4	0.6	-0.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	1.9	0.8	0.9	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	1.7	2.2	4.7	-1.1	1.6	0.4	2.2
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.4	-0.0	0.3	0.6
Systolic blood pressure, automated reading	0.4	1.1	2.4	1.0	-1.5	-1.0	-0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.4	-0.4	-1.2	0.7	-0.8
Angina	0.6	0.8	1.6	-0.0	1.1	-0.5	1.3
Medication for hormone replacement therapy	1.4	1.6	4.9	-1.1	0.2	0.3	2.2
Vitamin and mineral supplements	0.1	0.2	0.4	0.2	0.6	-0.5	0.4
Supplements: Zinc	1.1	1.2	2.7	-0.5	-1.6	1.1	-0.8
Medication: Co-codamol	0.6	0.7	1.3	1.1	-0.0	-1.0	-0.8
Medication: Metformin	0.8	1.2	2.0	-0.8	-1.4	1.2	-0.6
Diabetes (father)	0.1	0.2	0.4	-0.3	-0.4	0.6	-0.1
Diabetes (mother)	0.3	0.3	0.7	0.3	-0.8	-0.6	0.4
Severe depression (siblings)	0.2	0.2	0.5	-0.1	0.6	-0.0	0.7
Pack years adult smoking proportion	0.8	1.2	4.5	-0.0	-2.1	-0.1	0.3
Impedance of leg (right)	0.2	1.0	2.2	0.9	0.8	-1.5	0.7
Leg fat-free mass (left)	0.6	3.4	4.8	-1.1	-1.8	2.1	-2.2
Trunk fat percentage	0.2	0.8	1.8	-1.0	-0.2	0.7	1.3
Hand grip strength (right)	0.3	0.9	2.9	0.5	-1.7	-0.6	-0.5
Townsend deprivation index at recruitment	0.9	1.3	2.1	-1.4	-0.4	1.5	1.0
Current tobacco smoking	0.4	0.7	2.4	-0.5	-0.5	-0.1	1.5
Average weekly fortified wine intake	1.9	2.2	4.0	2.0	1.0	-1.5	-1.3
Maternal smoking around birth	0.3	0.4	1.2	-0.1	-1.1	0.3	-0.7
Fed-up feelings	0.4	0.6	1.7	-0.9	-0.0	1.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.5	-0.6	-0.6	0.7	0.1
Relative age voice broke	0.1	0.2	0.5	0.3	0.1	0.0	-0.7
Taking other prescription medications	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1
Age when periods started (menarche)	0.4	0.9	1.4	-1.2	-0.8	1.1	-0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.3	-0.6	1.2	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	0.5	0.7	-0.6	-0.0
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.1	1.4	1.2	-1.8	-0.1
Qualifications: CSEs or equivalent	0.4	0.6	1.8	-0.3	-0.0	0.6	-1.4
Serious illness, injury or assault to yourself	0.3	0.3	0.6	0.5	0.8	-0.6	-0.3
High blood pressure	0.6	1.8	5.3	-1.1	-2.3	0.8	0.5
Hayfever, allergic rhinitis or eczema	0.8	1.8	5.5	-0.6	2.3	0.3	1.1
Multivitamins +/- minerals	0.0	0.0	0.1	0.1	0.3	-0.2	0.3
Stomach or abdominal pain in last month	0.1	0.2	0.3	-0.2	0.5	0.6	-0.3
Supplements: Glucosamine	0.2	0.3	0.7	0.2	-0.6	-0.1	-0.8
Diverticular disease/diverticulitis (self-reported)	1.5	1.7	5.4	-0.9	0.8	0.2	2.3
Medication: Atenolol	0.6	0.8	2.2	-0.1	0.9	-0.0	1.5
Medication: Levothyroxine sodium	0.6	1.1	2.5	1.0	-0.6	-0.7	-1.6
Sitting height	0.7	4.9	10.2	-0.5	-3.2	1.2	-2.8
Chronic bronchitis/emphysema (father)	1.5	1.7	4.9	-0.7	-1.2	0.2	2.2
High blood pressure (mother)	0.3	0.4	1.3	-0.4	-0.2	-0.1	1.1
Body mass index (BMI)	0.3	1.3	2.2	-1.5	0.2	1.5	0.8
Impedance of leg (left)	0.2	0.9	2.3	0.9	-0.1	-1.5	0.7
Leg predicted mass (left)	0.7	3.6	4.9	-1.2	-1.9	2.2	-2.2
Trunk fat mass	0.2	0.7	1.0	-1.0	-0.8	1.0	0.5
Waist circumference	0.3	1.1	1.9	-1.3	-0.9	1.4	0.1
Number of incorrect matches in round	0.7	1.2	2.2	-0.7	-0.0	1.5	-1.4
Past tobacco smoking	0.9	1.6	3.8	1.6	-0.2	-2.0	0.1
Alcohol usually taken with meals	1.9	3.1	5.7	2.3	1.1	-2.4	-0.2
Nervous feelings	0.5	0.9	1.3	-1.0	1.2	1.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.0	-0.2	1.7	0.3	-0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.3	-0.5	0.1	-0.3
Hair/balding pattern: Pattern 2	1.3	1.6	4.7	-0.5	2.2	0.2	1.1
Had menopause	1.2	1.5	2.8	1.6	0.5	-1.7	-0.5
Had other major operations	0.3	0.4	1.0	0.8	-0.2	-1.0	0.1
Forced vital capacity (FVC)	0.0	0.2	0.6	0.3	0.8	-0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	0.9	0.6	-1.3	0.2
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	-1.3	-0.5	1.2	1.0
Qualifications: None of the above	2.3	4.9	9.3	-2.8	-1.4	3.0	0.6
Financial difficulties in last 2 years	0.4	0.5	0.8	-0.3	-0.8	0.6	-0.9
Mouth/teeth dental problems	0.7	1.1	2.0	0.9	1.2	-1.4	0.4
Heart attack	0.4	0.5	1.3	0.3	-0.5	-0.7	1.1
Allergy	0.6	1.3	3.7	0.7	-1.9	-0.5	-0.8
Pain all over the body in last month	0.8	0.9	3.4	0.3	-1.9	-0.2	0.1
Diabetes (self-reported)	0.3	0.5	1.4	0.0	-1.2	0.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.5	-1.0	1.2	0.8	0.8
Medication: Ramipril	2.3	2.9	10.4	-0.8	-3.2	0.5	0.5
Medication: Simvastatin	0.1	0.2	0.3	0.5	0.1	-0.6	0.5
Fluid intelligence score	0.9	1.8	5.1	-1.0	0.8	0.7	2.2
Illnesses of siblings	1.4	2.0	7.0	0.0	-0.8	0.5	-2.6
Neuroticism score	0.6	1.2	2.9	-1.2	-0.1	1.7	-0.6
Weight	0.3	1.5	2.2	-0.9	-1.1	1.5	-1.3
Impedance of arm (right)	0.1	0.5	1.0	0.5	0.4	-0.8	1.0
Arm fat percentage (right)	0.5	1.9	3.1	-1.6	0.3	1.4	1.8
Trunk fat-free mass	0.7	4.1	9.1	-0.4	-2.3	1.3	-3.0
Hip circumference	0.3	1.3	2.6	-1.1	-0.6	1.6	-1.1
Time employed in main current job	1.2	1.3	3.1	1.1	-1.8	-0.8	-0.7
Alcohol intake versus 10 years previously	0.4	0.6	1.2	-0.7	0.6	1.1	-0.6
Father’s age at death	0.3	0.4	1.4	0.3	-0.0	0.1	-1.2
Worrier / anxious feelings	1.0	2.0	3.4	-1.0	0.7	1.8	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.6	0.3	-0.3	-0.9
Falls in the last year	0.4	0.6	1.2	-0.5	-1.1	0.5	-0.7
Hair/balding pattern: Pattern 3	0.9	1.4	3.7	-0.9	-1.9	1.0	-0.1
Number of live births	0.1	0.2	0.5	0.4	0.0	-0.7	0.2
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.1	0.5	0.3	0.1
Pulse rate	0.7	1.2	3.2	-0.9	-1.8	0.5	0.6
Happiness	3.2	3.9	8.6	-2.5	-0.7	2.9	0.4
Noisy workplace	0.2	0.3	0.4	-0.6	-0.7	0.6	-0.3
Qualifications: A levels/AS levels or equivalent	1.2	2.6	6.8	0.9	0.7	-1.6	2.6
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.7	-0.9	-0.7	1.6	-1.2
Mouth/teeth dental problems: Dentures	1.4	2.3	4.9	-1.9	-0.5	2.2	0.9
Asthma	0.1	0.2	0.2	-0.4	0.3	0.5	0.5
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	9.0	-3.0	0.5	2.8	1.9
Medication: Cholesterol lowering	0.2	0.4	1.0	0.1	-0.5	-0.4	1.0
Depression (self-reported)	0.1	0.2	0.3	-0.1	0.5	0.2	-0.6
Medication: Lansoprazole	0.2	0.2	0.5	0.6	0.4	-0.7	-0.3
Prospective memory result	1.4	1.7	3.8	1.2	-0.1	-1.3	-1.9
Lung cancer (father)	0.3	0.4	0.6	0.6	-0.7	-0.8	-0.5
Illnesses of mother	0.7	0.9	1.8	-1.1	0.7	1.3	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	-0.1	-0.8	0.5	-0.7
Pulse wave Arterial Stiffness index	2.4	2.8	6.3	-2.0	-0.4	2.5	-0.8
Impedance of arm (left)	0.3	1.5	2.1	1.1	1.4	-1.4	0.7
Arm fat mass (right)	0.3	1.1	2.3	-1.4	-0.2	1.5	0.4
Trunk predicted mass	0.7	4.1	9.7	-0.4	-2.2	1.3	-3.1
Standing height	0.8	7.6	21.0	1.2	-2.8	0.0	-4.6
Length of working week for main job	3.4	3.8	6.0	-2.4	-1.3	2.4	1.3
Exposure to tobacco smoke at home	1.8	2.0	4.1	-1.3	-2.0	0.9	1.2
Breastfed as a baby	0.9	1.2	2.3	-1.5	-0.5	1.5	-0.0
Tense / ‘highly strung’	1.0	1.6	2.8	-1.7	0.5	1.7	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	-0.8	1.4	0.6	0.9
Hair/balding pattern: Pattern 4	1.3	3.3	7.0	-2.4	-0.3	2.6	0.6
Birth weight of first child	0.9	1.7	3.3	1.0	1.8	-1.5	0.3
Peak expiratory flow (PEF)	0.1	0.3	0.8	0.6	-0.2	-0.2	-0.9
Pulse wave reflection index	0.6	0.8	1.2	-0.8	1.1	1.1	-0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.7	-0.1	0.2	0.6	-1.3
Loud music exposure frequency	4.7	5.1	11.5	2.0	1.9	-1.1	-3.4
Qualifications: O levels/GCSEs or equivalent	1.6	2.5	4.5	1.9	0.8	-2.1	1.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-0.4	-1.4	0.8	-0.5
Blood clot in the leg (DVT)	1.3	1.7	2.9	-1.7	-0.6	1.7	0.8
Medication: Paracetamol	0.6	1.1	3.1	-0.5	1.8	0.8	-0.6
Headache pain in last month	0.5	0.9	1.9	-1.3	0.1	1.4	-0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.4	0.5	-0.2	-0.7
Glaucoma (self-reported)	0.4	0.4	1.6	0.0	-1.3	-0.4	0.1
Gout (self-reported)	1.7	2.3	3.6	-1.9	1.3	1.7	1.0
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.5	1.1	-0.1	-1.0	-1.2
Medication: Amlodipine	1.2	1.7	3.0	-1.7	-0.8	1.7	0.6
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.5	-0.0	0.4	0.6	-0.7
Birth weight	1.2	2.5	3.6	1.9	1.4	-1.8	-1.1
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.4	1.2	0.7	-0.9	-1.1
High blood pressure (siblings)	0.4	0.5	1.7	-0.2	0.6	0.0	1.3
Forced vital capacity (FVC), Best measure	0.2	0.7	1.5	0.9	-0.6	-0.4	-1.2
Body fat percentage	0.3	1.3	2.8	-1.2	0.1	0.9	1.7
Leg fat percentage (right)	0.4	1.3	2.7	-1.1	0.9	0.7	1.6
Arm fat-free mass (right)	0.5	2.7	6.9	-0.3	-1.6	1.1	-2.6
Exposure to tobacco smoke outside home	0.5	0.7	1.0	0.7	1.0	-1.0	-0.3
Comparative body size at age 10	0.4	1.1	2.3	-0.1	1.5	-0.3	1.4
Number of full brothers	0.8	1.0	3.4	-0.2	0.6	-0.5	1.9
Worry too long after embarrassment	1.1	1.8	4.0	-1.7	0.5	2.0	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.4	-0.0	0.5	-0.2	1.2
Wheeze or whistling in the chest in last year	0.1	0.2	0.9	0.2	0.1	0.1	-0.9
Number of children fathered	0.6	0.7	2.0	-0.4	0.8	0.1	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-0.3	0.4	0.9	-1.2
Age at first live birth	0.0	0.1	0.2	0.1	0.4	-0.1	-0.4
Pulse wave peak to peak time	2.4	2.9	6.6	2.2	0.3	-2.6	0.3
Health satisfaction	0.3	0.4	1.1	-0.3	1.0	0.5	0.2
Shortness of breath walking on level ground	1.9	2.2	3.9	-2.0	-1.2	1.7	0.8
Qualifications: College or University degree	0.2	0.6	1.7	0.3	-0.1	-0.8	1.3
Eye problems/disorders: None of the above	1.7	1.9	4.0	-1.5	0.6	1.1	2.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.7	-0.2	0.7	-0.1
Emphysema/chronic bronchitis	0.5	0.6	0.8	0.7	0.9	-0.6	-0.7
Medication for pain relief, constipation, heartburn	1.1	1.9	2.8	1.7	-0.3	-1.6	-1.5
Neck or shoulder pain in last month	1.7	2.4	9.0	0.2	-3.0	-0.2	-0.8
Medication: Blood pressure	0.6	1.0	1.6	-1.0	-1.1	1.3	-0.3
Angina (self-reported)	0.4	0.5	1.1	-0.1	0.9	-0.3	1.1
Migraine (self-reported)	2.1	2.6	4.5	1.6	1.8	-2.1	0.3
Medication: Ibuprofen	4.6	5.5	9.8	-3.1	0.3	3.1	1.6
Medication: Allopurinol	2.2	2.9	5.5	-1.8	1.1	1.3	2.4
Medication: Omeprazole	0.7	0.8	1.4	-0.6	-1.2	1.1	-0.6
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.4	0.7	-0.6	0.5
Mean time to correctly identify matches	2.7	5.1	7.6	-2.8	-2.2	2.5	1.3
Heart disease (mother)	0.8	1.0	1.8	-0.8	-1.1	0.6	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.4	-1.4	0.3	1.8	-0.4
Whole body fat mass	0.3	1.1	2.0	-1.3	-0.6	1.4	0.4
Leg fat mass (right)	0.3	1.2	2.3	-1.4	-0.3	1.5	0.4
Arm predicted mass (right)	0.6	3.1	7.0	-0.3	-2.0	1.2	-2.6
Pulse rate, automated reading	1.0	3.3	8.2	-1.6	-2.9	1.4	0.8
Alcohol intake frequency.	0.1	0.2	0.4	-0.6	-0.2	0.6	0.2
Comparative height size at age 10	1.1	5.9	12.6	2.1	-2.1	-1.4	-3.5
Number of full sisters	0.4	0.5	0.7	-0.8	0.8	0.8	-0.3
Suffer from ‘nerves’	0.2	0.2	0.7	-0.2	-0.9	0.4	-0.2
Overall health rating	0.8	1.7	3.0	-1.7	-0.7	1.7	0.7
Chest pain or discomfort	0.4	0.6	1.8	-0.4	0.5	-0.3	1.3
Had major operations	0.3	0.3	1.0	-0.2	1.0	-0.1	0.4
Age at last live birth	0.6	0.9	1.5	-1.2	0.3	1.1	0.9
Family relationship satisfaction	0.5	0.6	1.7	0.4	-0.6	0.2	-1.3
Leg pain on walking	2.3	2.9	5.8	-1.8	-1.3	2.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	6.4	0.3	1.0	0.6	-2.5
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	-0.7	-0.8	0.9	-0.3
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	6.4	-1.0	-0.6	0.2	2.5
Medication: Aspirin	0.3	0.4	1.4	0.2	-0.2	-0.5	1.2
Supplements: Vitamin C	0.6	0.7	1.8	0.1	0.9	0.5	-1.4
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	-0.0	0.6	0.2
Hypertension (Self-reported)	0.7	1.9	5.1	-1.2	-2.3	1.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.4	-0.7	-0.1	1.2	-0.5
Illnesses of father: Heart disease	1.0	1.4	3.0	-0.7	-1.7	0.3	1.4
Illnesses of siblings: Diabetes	1.0	1.3	3.8	-0.7	-0.7	0.5	1.9
Smoking status: Previous	0.7	1.1	2.7	-1.2	0.0	1.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.2	8.8	1.8	-0.1	-1.0	-3.0
Whole body fat-free mass	0.7	4.2	8.0	-0.7	-2.3	1.7	-2.8
Leg fat-free mass (right)	0.7	3.8	5.6	-0.9	-2.2	1.9	-2.4
Arm fat percentage (left)	0.4	1.7	3.2	-1.3	0.8	1.0	1.8
Average weekly red wine intake	1.8	2.7	5.1	2.3	0.7	-2.1	-0.9
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.5	0.5	-0.9	-0.2	-1.2
Mood swings	1.0	1.8	3.8	-1.7	-0.5	2.0	0.1
Loneliness, isolation	0.7	0.9	2.0	-1.2	-0.2	1.4	0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.4	0.2	-0.2	-0.6	-0.1
Ever had bowel cancer screening	4.1	4.8	8.0	-2.8	-1.4	2.8	1.1
Diabetes diagnosed by doctor	0.2	0.3	1.0	-0.2	-1.0	0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.7	-0.7	-0.5	1.3	-1.0
Friendships satisfaction	0.9	1.1	2.8	-1.1	-0.4	1.7	-0.4
Qualifications: nursing, teaching	0.8	1.2	4.2	0.1	2.0	-0.3	0.8
Commuting to job workplace: Walk	0.3	0.3	0.6	0.8	0.5	-0.7	0.1
Eye problems/disorders: Cataract	1.8	2.1	3.6	1.8	-0.9	-1.9	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.2	-0.8	0.5	-0.8
Medication for cholesterol	0.6	0.9	2.5	0.1	0.9	0.5	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.7	-0.6	0.8	0.7	0.4
Back pain experienced in last month	0.1	0.2	0.5	-0.2	-0.1	0.2	-0.7
Mineral and other dietary supplements	0.2	0.3	0.4	0.6	-0.4	-0.6	-0.4
Breast cancer (self-reported)	0.7	0.9	1.0	1.0	-0.9	-0.9	-0.9
Asthma (self-reported)	0.3	0.7	1.2	-1.1	-0.2	1.1	0.6
Osteoporosis (self-reported)	1.0	1.3	3.1	0.9	1.8	-1.1	0.1
Osteoarthritis (self-reported)	0.4	0.5	0.9	0.5	0.7	-1.0	-0.5
Medication: Aspirin	0.5	0.6	1.8	0.3	-0.0	-0.7	1.3
Medication: Gliclazide	0.2	0.2	0.4	0.3	0.4	-0.5	0.6
Illnesses of father: None of the above (group 1)	1.0	1.3	4.6	0.3	2.1	-0.2	-0.6
Smoking status: Current	0.2	0.4	1.3	-0.4	-0.0	-0.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.2	-1.1	-1.0	1.0	0.9
Whole body water mass	0.7	4.0	7.2	-0.8	-2.2	1.8	-2.7
Leg predicted mass (right)	0.7	3.7	5.2	-0.9	-2.2	1.9	-2.3
Arm fat mass (left)	0.1	0.6	1.2	-1.0	0.2	1.1	0.2
Number of self-reported non-cancer illnesses	0.9	1.5	1.9	-1.4	-1.2	1.0	1.2
Average weekly champagne plus white wine intake	1.2	1.7	5.4	0.2	2.3	-0.7	0.9
Miserableness	2.4	4.1	6.8	-2.5	1.8	2.6	0.4
Guilty feelings	1.1	1.7	2.8	-1.3	1.5	1.7	-0.2
Wears glasses or contact lenses	0.4	0.5	1.2	0.5	0.7	0.0	-1.1
Ever taken oral contraceptive pill	0.3	0.4	0.9	-0.4	-0.7	0.1	0.9
Hearing aid user	1.2	1.4	4.9	0.4	2.2	-0.6	0.2
Mother’s age at death	1.3	1.6	2.9	1.3	1.7	-1.4	0.2
Financial situation satisfaction	1.6	2.0	3.7	-1.2	-0.5	1.9	-1.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.7	-0.7	-0.6	1.3	-1.0
Commuting to job workplace: Public transport	0.5	0.6	0.8	0.9	0.7	-0.7	-0.9
Eye problems/disorders: Glaucoma	2.3	2.7	3.9	1.8	-1.4	-2.0	-1.2
Medication: Blood pressure	0.3	0.6	1.7	-0.2	-1.3	-0.2	0.9
Pain type(s) experienced in last month: Hip pain	1.6	2.0	3.2	1.5	-1.1	-1.2	-1.8
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	-0.5	0.5	0.5	0.2
High cholesterol (Self-reported)	0.6	1.0	1.4	-1.1	-0.9	1.2	0.8
Medication: Bendroflumethiazide	0.1	0.1	0.4	-0.1	-0.4	-0.2	0.6
Medication: Paracetamol	0.4	0.6	1.0	-0.8	0.7	1.0	-0.4
Medication: Lisinopril	0.6	0.8	2.5	0.1	-0.7	0.6	-1.6
Medication: Atorvastatin	0.8	1.0	2.2	-1.1	-0.6	0.5	1.5
Illnesses of father: High blood pressure	0.3	0.3	0.5	0.7	0.4	-0.5	-0.7
Alcohol drinker status: Never	4.1	4.9	8.1	2.7	1.2	-2.8	-1.7
Ever smoked	1.7	3.0	5.9	-2.2	-0.2	2.4	1.0
Basal metabolic rate	0.6	3.6	6.1	-0.9	-2.0	1.8	-2.5
Leg fat percentage (left)	0.3	1.0	2.7	-1.0	0.3	0.6	1.6
Arm fat-free mass (left)	0.7	3.4	7.9	-0.5	-1.9	1.4	-2.8
Number of operations (self-reported)	0.4	0.6	1.5	0.7	1.2	-0.5	-0.4
Average weekly beer plus cider intake	2.3	3.4	5.0	-2.0	-2.2	2.0	0.6
Irritability	2.7	4.6	8.1	-2.7	-0.9	2.8	1.4
Risk taking	0.8	1.1	1.6	-1.3	0.9	1.1	1.0
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.1	-0.7	0.1	0.6
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.2	-0.0	0.4	-0.5
Age started oral contraceptive pill	0.9	1.2	2.8	1.1	-0.4	-0.7	-1.7
Diastolic blood pressure, automated reading	0.7	2.0	3.2	-1.4	-1.3	1.1	1.8
Ever depressed for a whole week	0.7	0.9	3.6	-0.1	-1.9	0.0	-0.2
Unable to work because of sickness or disability	1.8	2.3	4.4	-1.8	0.1	1.3	2.1
Commuting to job workplace: Cycle	0.4	0.5	2.0	-0.3	-1.4	0.2	-0.0
Myopia	0.1	0.2	0.6	0.4	-0.8	-0.1	-0.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.4	0.9	1.8	-0.4	-1.1
Cholesterol lowering medication	0.1	0.1	0.2	-0.2	-0.2	0.4	0.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.6	-0.6	-1.6	0.9	-0.3
Pain experienced in last month	0.5	0.9	1.8	1.1	0.7	-1.3	0.4
Supplements: Calcium	0.5	0.5	1.6	-0.2	-1.3	0.3	-0.5
Basal cell carcinoma (self-reported)	0.9	1.0	1.5	-1.2	-0.6	1.0	1.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.2	0.0	-0.6	-0.5	1.1
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.2	-1.5	-0.2	1.4	1.1
Heart disease (siblings)	1.0	1.2	3.8	0.3	0.3	-0.9	2.0
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.3	-0.4	0.4	-0.2
Pack years of smoking	0.7	1.1	4.0	0.4	-2.0	-0.5	0.1
Impedance of whole body	0.2	1.0	2.1	1.0	0.7	-1.4	0.7
Leg fat mass (left)	0.3	1.3	2.3	-1.5	-0.7	1.5	0.5
Arm predicted mass (left)	0.8	3.9	6.6	-0.9	-2.2	1.8	-2.6