TWAS hub - MPP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1340	0.0440	5.4e-06	0.021	0.048	0.083	0.063	0.064	1.1e-03	1.5e-06	2.8e-10	4.0e-08	3.3e-08
2	GTEx	Pancreas	0.2800	0.1040	1.6e-03	0.026	NA	0.026	NA	0.059	2.7e-02	NA	2.7e-02	NA	1.7e-03
3	GTEx	Skin Not Sun Exposed Suprapubic	0.3790	0.0590	5.3e-12	0.355	NA	0.301	NA	0.339	2.5e-20	NA	6.3e-17	NA	2.4e-19
4	GTEx	Skin Sun Exposed Lower leg	0.3340	0.0510	7.2e-16	0.291	NA	0.286	NA	0.297	2.2e-24	NA	6.8e-24	NA	7.0e-25
5	METSIM	Adipose	0.1546	0.0388	4.3e-10	0.068	0.058	0.089	0.072	0.085	2.1e-10	5.1e-09	3.0e-13	5.6e-11	1.1e-12
6	NTR	Blood	0.0228	0.0098	4.5e-03	0.010	0.002	0.000	0.003	0.004	2.7e-04	4.3e-02	2.4e-01	3.2e-02	2.1e-02
7	YFS	Blood	0.0230	0.0104	3.2e-03	0.002	0.006	0.010	0.007	0.005	4.7e-02	4.6e-03	1.7e-04	1.6e-03	8.6e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Happiness	5.3	6.4	14.8	3.9	0.8	1.9	2.0	3.2	2.5	2.4
Diverticular disease/diverticulitis (self-reported)	4.6	5.5	10.3	-0.7	-1.2	-2.2	-2.2	-3.1	-2.7	-3.2
Chronic bronchitis/emphysema (mother)	4.5	5.2	10.3	0.2	2.5	2.9	3.2	2.4	1.0	2.2
Loneliness, isolation	4.5	6.2	9.9	1.1	-3.1	-3.1	-3.1	-2.3	-0.9	-2.6
Health satisfaction	4.4	5.7	10.9	1.8	3.3	2.7	2.8	1.8	1.6	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.4	5.2	13.6	-0.8	-1.0	-2.3	-2.2	-3.7	-2.3	-2.3
Length of working week for main job	4.3	4.7	11.6	-3.4	1.6	2.7	2.7	0.8	-1.7	1.0
Medication: Co-codamol	3.9	4.6	11.1	-1.7	-0.8	-1.7	-1.8	-3.3	-2.5	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	3.9	8.9	23.5	1.2	0.4	-2.4	-2.4	-3.3	-3.8	-4.8
Had menopause	3.9	4.8	9.7	1.6	2.0	2.0	2.1	2.8	3.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	3.7	8.5	18.7	0.1	0.3	-2.2	-2.2	-3.7	-4.1	-4.3
Heel T-Score	3.6	28.4	80.8	-0.0	2.3	-2.0	-2.0	-6.3	-8.0	-9.0
Mean Putamen Volume	3.5	4.0	10.0	3.2	2.6	1.0	1.0	0.9	2.5	1.5
Noisy workplace	3.5	4.3	10.5	1.0	3.2	2.7	2.9	1.3	0.4	0.8
Ulcerative Colitis (UC)	3.3	6.2	11.0	0.9	3.3	2.9	3.0	3.1	1.2	1.9
Heart disease (siblings)	3.2	3.9	8.0	-0.4	2.7	1.7	1.9	2.1	0.8	2.8
Birth weight	3.0	6.5	13.3	1.5	2.1	2.8	2.7	3.6	1.9	2.7
Headache pain in last month	2.9	4.9	11.7	1.1	-2.3	-3.4	-3.4	-1.3	-0.3	-1.7
Frequency of depressed mood in last 2 weeks	2.7	3.8	10.1	1.4	-3.2	-2.1	-2.1	-0.4	-1.2	-2.0
Shortness of breath walking on level ground	2.7	3.3	7.4	2.7	2.4	1.5	1.7	1.7	0.8	0.8
Comparative body size at age 10	2.6	7.1	16.0	-2.9	-1.4	-1.2	-1.3	-4.0	-3.4	-2.9
Age started oral contraceptive pill	2.6	3.2	8.5	0.3	1.3	1.1	1.2	2.9	2.2	2.1
Alcohol intake frequency.	2.5	5.7	20.5	-0.6	-4.5	-2.4	-2.5	-1.7	-2.0	-0.7
Prospective memory result	2.4	2.9	6.0	0.0	1.2	2.1	2.1	2.4	1.4	1.4
Loud music exposure frequency	2.4	2.6	5.6	2.4	0.9	1.6	1.6	1.0	1.7	1.8
Pulse wave peak to peak time	2.4	2.8	6.7	-1.3	-1.1	-0.4	-0.6	-2.2	-2.6	-2.1
Emphysema/chronic bronchitis	2.3	2.6	5.0	-0.6	1.4	2.1	2.2	1.1	1.0	2.0
Wears glasses or contact lenses	2.3	2.6	6.6	1.9	0.5	1.3	1.4	1.8	1.0	2.6
Ever had prostate specific antigen (PSA) test	2.3	2.6	5.9	-2.4	-0.4	1.8	1.4	-1.0	-2.3	1.0
Body Mass Index (BMI) (2010)	2.2	3.1	5.9	0.6	2.4	2.3	2.4	1.0	1.5	1.1
Father’s age at death	2.1	2.8	5.1	-0.8	0.8	1.9	2.0	1.6	1.7	2.2
Fractured/broken bones in last 5 years	2.1	2.7	9.2	2.0	-1.3	0.0	0.0	1.4	3.0	1.4
Irritable Bowel Disease (IBD)	2.0	4.8	8.8	1.0	2.8	2.4	2.4	3.0	1.2	1.4
Pain type(s) experienced in last month: Hip pain	2.0	2.5	13.1	3.6	1.7	-0.1	0.2	0.7	0.9	0.3
Pack years of smoking	2.0	3.0	7.2	-1.0	1.5	2.7	2.7	0.6	-0.4	1.7
Blood Platelet Count	1.9	22.4	48.4	-0.9	-4.3	-5.8	-5.7	-0.1	-4.8	-7.0
Blood White Count	1.9	13.9	26.9	-5.1	-2.8	-3.0	-3.3	-3.0	-2.7	-5.2
Vitamin and mineral supplements	1.9	2.6	3.5	1.6	1.6	1.6	1.7	1.1	1.9	1.6
Exposure to tobacco smoke outside home	1.9	2.5	3.6	-1.6	-1.8	-1.2	-1.2	-1.9	-1.5	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	2.6	-1.6	-1.5	-1.6	-1.6	-1.3	-0.9	-1.6
Ulcerative Colitis	1.8	2.5	6.7	1.7	2.6	0.5	0.6	1.9	1.8	0.9
Pulse wave Arterial Stiffness index	1.8	2.1	5.3	1.4	1.1	0.3	0.5	1.8	2.3	1.8
Pulse wave reflection index	1.8	2.2	3.2	1.1	1.6	1.0	1.2	1.8	1.8	1.6
Ever depressed for a whole week	1.8	2.2	7.9	2.8	0.5	0.9	1.1	0.7	1.8	1.2
Intelligence (Savage-Jansen 2018)	1.7	5.3	8.8	2.5	3.0	2.0	2.4	1.1	1.5	2.9
Blood Eosinophil Count	1.7	13.0	32.1	-5.7	-2.5	-2.4	-2.9	-2.9	-3.1	-4.6
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	3.5	0.7	0.5	1.7	1.7	1.5	0.7	1.9
Hand grip strength (right)	1.7	4.6	14.3	-3.8	0.6	0.7	0.5	-2.5	-3.0	-1.1
Serious illness, injury or assault to yourself	1.7	2.0	8.8	3.0	0.1	0.6	0.5	1.1	1.8	0.8
Friendships satisfaction	1.7	2.1	8.6	2.9	1.2	-0.5	-0.3	1.2	1.6	0.2
Medication: Gliclazide	1.7	1.9	6.9	-2.6	0.5	1.1	1.0	-0.8	-1.7	-0.8
Tinnitus: Yes, now most or all of the time	1.7	2.0	10.8	3.3	0.8	-0.9	-0.6	-0.2	0.9	0.2
Alcohol drinker status: Previous	1.7	2.0	4.5	-0.2	-1.5	-2.1	-2.0	-0.6	-1.2	-0.9
Diabetes (mother)	1.6	2.0	7.1	-0.1	-2.7	-1.7	-1.6	0.1	0.9	-0.8
Chronic bronchitis/emphysema (father)	1.6	1.9	5.1	0.2	1.3	0.2	0.4	2.0	2.2	1.4
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	13.8	-3.1	-0.4	-0.6	-0.9	-3.7	-3.4	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	8.7	-2.9	-0.7	-0.5	-0.7	-2.9	-2.0	-1.4
Prostate Cancer	1.5	2.1	5.9	-1.8	-2.4	-0.9	-1.0	-1.8	-0.5	-0.2
Fasting Glucose	1.5	1.8	4.0	-1.1	2.0	1.4	1.5	1.7	-0.5	-0.1
HDL Cholesterol	1.5	2.4	8.4	1.8	-1.5	-0.9	-0.7	1.4	2.9	0.1
Ever highly irritable/argumentative for 2 days	1.5	1.7	4.5	0.7	-1.5	-0.3	-0.5	-1.4	-2.1	-1.6
Leg pain on walking	1.5	1.9	6.0	1.9	2.4	1.3	1.4	-0.1	0.2	-0.2
Depression (Nagel 2018)	1.4	2.1	4.4	0.9	-2.1	-1.6	-1.7	0.1	-1.4	-1.5
Alzheimer’s Disease (in father)	1.4	1.6	2.7	-1.2	-1.2	-1.1	-1.3	-1.6	-0.3	-1.6
Verbal and Numeric Reasoning (VNR)	1.4	3.2	5.9	1.9	2.0	1.5	1.7	1.0	1.8	2.4
Waist Hip Ratio (WHR)	1.4	6.5	10.0	0.3	-1.1	-2.9	-2.8	-3.1	-2.8	-3.2
Medication: Omeprazole	1.4	1.7	5.7	0.4	-0.3	-1.5	-1.6	-2.4	-0.1	-0.9
Type 2 Diabetes (T2D) (2018)	1.3	2.4	6.3	-0.8	-0.7	-1.7	-1.7	-2.5	-1.2	-1.5
Past tobacco smoking	1.3	2.5	5.5	-2.3	-1.4	-1.5	-1.5	-1.5	-1.3	-1.3
Qualifications: None of the above	1.3	2.8	6.3	-1.1	1.5	1.9	1.9	2.5	1.0	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	4.0	0.2	1.0	1.3	1.4	2.0	1.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	10.9	-3.3	0.1	-0.2	-0.5	-3.1	-2.9	-1.1
Medication: Seretide 50 evohaler	1.3	1.5	3.4	-1.9	-0.8	-0.8	-0.5	-1.3	-1.8	-0.9
Long-standing illness, disability or infirmity	1.3	2.0	3.4	0.8	-1.1	-1.6	-1.6	-1.9	-1.3	-1.3
Ever smoked	1.3	2.2	7.3	2.7	0.6	1.4	1.4	1.6	0.4	1.2
Bipolar Disorder (2018)	1.2	1.9	5.0	-2.2	0.3	1.8	1.8	0.9	-1.1	-0.0
Triglycerides	1.2	2.0	10.4	-1.5	0.2	-0.4	-0.5	-0.8	-3.2	0.2
Townsend deprivation index at recruitment	1.2	1.7	5.1	2.1	0.6	-0.4	-0.2	0.9	2.3	0.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	3.9	0.5	-2.0	-1.3	-1.3	-0.7	-1.4	-1.7
Worrier / anxious feelings	1.2	2.2	4.8	0.5	-2.2	-1.7	-1.8	-0.1	-0.0	-2.1
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	4.7	1.5	-1.3	-2.1	-2.2	-0.1	1.5	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	3.8	2.0	0.3	0.7	0.8	1.9	0.5	1.4
Average weekly red wine intake	1.2	1.8	4.6	-0.9	0.2	-1.1	-1.2	-1.9	-2.1	-1.2
Osteoarthritis (self-reported)	1.2	1.5	3.9	-0.1	1.4	1.4	1.3	-1.0	-0.5	-2.0
Guilty feelings	1.2	1.8	5.2	1.4	-1.4	-0.8	-1.0	-1.3	-0.2	-2.3
Illnesses of father: High blood pressure	1.2	1.4	4.3	-0.5	-2.1	-0.5	-0.8	-1.3	-1.6	-0.6
Risk taking	1.2	1.7	4.2	-0.8	-1.9	-1.0	-1.1	-1.0	-0.7	-2.0
Average weekly fortified wine intake	1.1	1.3	4.0	2.0	-1.4	-1.1	-1.2	-0.1	-0.6	0.3
Maternal smoking around birth	1.1	1.6	4.6	2.2	0.9	0.1	0.2	0.6	1.8	1.4
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	5.2	0.3	-2.3	-0.1	-0.3	1.1	-0.2	-1.1
Number of live births	1.1	1.6	6.5	-1.0	-2.5	-1.0	-1.2	0.1	-0.8	-0.8
Age at last live birth	1.1	1.5	4.0	-0.9	-1.4	-0.8	-1.0	-2.0	-1.4	-0.6
Supplements: Vitamin C	1.1	1.2	3.1	-1.7	-0.8	-0.4	-0.6	-0.5	-1.8	-1.1
Medication: Paracetamol	1.1	1.8	4.7	0.1	-0.3	-1.2	-1.2	-2.2	-2.0	-0.8
Myopia	1.1	1.6	2.1	-1.4	-0.9	-1.1	-1.1	-1.5	-1.4	-1.3
Cardiovascular Disease	1.0	3.3	7.5	0.1	-1.6	-2.5	-2.7	-1.3	-1.5	-1.6
Hand grip strength (left)	1.0	2.6	7.9	-2.8	1.3	1.1	1.0	-1.4	-1.9	-0.4
Pack years adult smoking proportion	1.0	1.5	3.7	-1.0	0.8	1.9	1.9	-0.0	-0.7	1.1
Qualifications: CSEs or equivalent	1.0	1.3	3.6	1.4	-0.5	-0.8	-1.0	-1.2	0.3	-1.9
Medication: Paracetamol	1.0	1.7	2.7	0.8	-0.7	-1.5	-1.4	-1.7	-1.6	-1.1
Had major operations	1.0	1.2	3.0	-1.2	-1.7	1.2	0.9	0.7	1.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	6.3	-1.0	-2.5	0.2	-0.1	0.2	-0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	5.5	-0.2	-0.3	-1.0	-1.0	-2.4	-0.3	-0.7
Supplements: Glucosamine	0.9	1.1	3.3	0.3	1.3	-0.4	-0.4	-1.4	-0.6	-1.8
Medication: Levothyroxine sodium	0.9	1.6	3.8	0.7	-1.0	-1.6	-1.5	0.5	2.0	-0.8
Alcohol usually taken with meals	0.9	1.4	2.4	-0.4	-1.3	-1.4	-1.5	-1.1	-1.2	-0.9
Financial difficulties in last 2 years	0.9	1.3	1.8	0.9	-1.3	-1.3	-1.3	-0.8	1.3	-0.6
Medication: Amlodipine	0.9	1.3	3.5	1.0	-0.7	-1.8	-1.9	-0.3	0.3	-0.8
Number of children fathered	0.9	1.1	2.6	-1.0	1.6	1.2	1.1	0.5	-0.5	0.7
Medication: Allopurinol	0.9	1.2	1.8	1.2	0.1	-1.3	-1.3	-0.5	1.3	-1.3
Family relationship satisfaction	0.9	1.1	5.5	2.3	0.4	0.2	0.2	0.5	1.3	0.3
Smoking status: Previous	0.9	1.4	2.5	1.3	1.1	1.0	1.0	0.9	1.6	1.2
Asthma (self-reported)	0.9	1.7	3.6	-0.3	-1.7	-1.4	-1.4	-0.7	-0.9	-1.9
Number of self-reported non-cancer illnesses	0.9	1.6	4.5	1.0	-0.9	-2.1	-2.0	0.4	0.6	-0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	4.5	0.6	-0.2	-0.8	-0.8	-2.1	-0.7	-1.2
Crohns Disease (2017)	0.8	1.7	3.4	0.6	1.5	1.5	1.5	1.9	0.7	1.0
Age at First Birth	0.8	1.1	2.6	0.2	-1.6	-1.1	-1.1	-0.9	0.4	-1.5
HbA1C	0.8	0.9	2.1	-1.5	0.5	0.7	0.8	1.1	0.9	0.9
Blood Red Count	0.8	7.7	12.2	1.6	2.5	3.1	3.2	2.1	3.5	3.0
Forced vital capacity (FVC)	0.8	3.1	7.3	-2.7	-0.1	-0.0	-0.2	-2.5	-2.7	-0.8
Medication: Lansoprazole	0.8	0.9	3.7	-0.5	-0.5	0.3	0.1	-1.9	-1.3	-0.7
Neck or shoulder pain in last month	0.8	1.1	3.9	1.1	-0.1	-0.9	-0.8	-2.0	-0.7	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	5.4	2.3	-0.2	0.0	0.0	0.8	0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.6	0.3	-0.9	-1.9	-1.8	-1.2	-0.1	-1.3
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.7	-1.3	-0.3	-0.9	-1.1	-1.2	-1.1	-0.6
Major Depression (MDD)	0.7	0.8	1.3	-0.4	-0.7	-1.1	-1.2	-0.0	-1.1	-1.1
Lupus	0.7	1.1	2.8	-1.4	-1.7	-0.5	-0.8	-1.3	-0.7	-0.1
Lung FVC	0.7	3.6	11.6	-3.4	0.6	1.2	1.1	-1.2	-2.9	0.9
Sensitivity / hurt feelings	0.7	1.3	5.5	1.2	-0.7	-0.8	-0.7	0.3	2.4	-0.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.4	0.4	1.5	0.7	0.9	0.4	0.8	1.3
Severe depression (siblings)	0.7	0.8	2.0	1.4	-0.3	-1.1	-1.0	-0.8	0.3	0.7
High blood pressure	0.7	1.9	5.4	2.3	-0.4	-1.6	-1.5	0.7	1.3	0.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	3.0	0.6	-1.3	-1.5	-1.7	-0.4	-1.3	-1.3
Stomach or abdominal pain in last month	0.7	0.8	2.6	1.0	-1.0	-0.7	-0.7	-0.4	-0.2	-1.6
Hearing difficulty/problems with background noise	0.7	1.1	3.4	1.8	1.8	0.2	0.4	-0.4	0.9	0.5
Heart attack	0.7	0.9	2.0	-1.1	-0.0	1.4	1.4	-0.6	-0.9	-0.4
Diabetes (self-reported)	0.7	1.1	3.2	0.0	0.0	-1.1	-1.1	-1.8	-0.6	-1.2
Hair/balding pattern: Pattern 3	0.7	1.1	4.4	-0.9	-0.5	1.0	0.8	0.0	-0.7	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.7	-0.8	-1.6	-1.0	-1.1	-0.8	-0.2	-0.2
Tense / ‘highly strung’	0.7	1.1	6.5	2.5	-0.2	-0.4	-0.4	0.6	0.8	-0.3
Peak expiratory flow (PEF)	0.7	1.7	4.3	-1.8	-0.7	-0.9	-1.1	-2.1	-1.5	-0.3
Blood clot in the leg (DVT)	0.7	1.0	4.1	0.7	0.6	-0.3	-0.2	2.0	1.2	0.1
Forced vital capacity (FVC), Best measure	0.7	2.7	7.8	-2.8	0.2	0.2	0.0	-2.0	-2.4	-0.9
Worry too long after embarrassment	0.7	1.1	3.3	1.8	-0.1	-1.1	-0.9	0.2	1.4	-0.6
Mean time to correctly identify matches	0.7	1.3	4.5	0.6	0.4	0.2	0.3	2.1	1.6	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.1	0.6	-1.1	-1.4	-1.4	-0.5	-0.6	0.2
Hypertension (Self-reported)	0.7	2.0	4.4	2.1	-0.8	-2.0	-2.0	0.3	0.9	0.2
Mood swings	0.7	1.3	3.2	1.8	-1.1	-0.5	-0.6	1.0	1.3	-1.0
Eye problems/disorders: Cataract	0.7	0.9	2.3	1.5	-0.9	-0.4	-0.5	1.2	1.0	0.3
Back pain experienced in last month	0.7	1.0	5.3	2.3	0.9	-0.2	-0.2	0.3	0.6	0.7
Breast cancer (self-reported)	0.7	0.9	3.8	0.2	0.5	0.5	0.5	1.9	0.7	1.0
Medication: Blood pressure	0.7	1.3	5.1	2.2	0.7	0.2	0.2	0.9	1.4	0.9
Allergy or Eczema	0.6	1.6	3.2	0.4	-1.4	-1.6	-1.8	-0.2	-0.6	-1.6
Respiratory disease	0.6	1.3	2.3	0.1	-1.5	-1.3	-1.3	-0.3	-1.1	-1.3
Lung FEV1/FVC ratio	0.6	3.1	10.5	-1.6	0.4	-0.6	-0.9	-3.2	-2.7	-0.2
Relative age voice broke	0.6	1.0	1.5	1.1	0.7	1.2	1.2	0.5	-0.6	1.2
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.6	-1.6	-1.1	0.4	0.3	-0.1	-0.6	0.1
Multivitamins +/- minerals	0.6	0.7	1.4	-0.4	-0.2	-1.2	-1.1	-0.7	-0.6	-1.2
Mouth/teeth dental problems	0.6	0.9	2.8	-0.1	-0.5	-0.5	-0.8	-1.7	-1.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.9	3.1	-1.0	-0.9	-0.6	-0.7	0.4	-1.7	-0.5
Time employed in main current job	0.6	0.7	1.2	-0.8	-0.2	1.1	1.0	0.7	-1.1	0.6
Asthma	0.6	1.3	2.8	-0.5	-1.7	-1.2	-1.1	-0.4	-0.9	-1.5
Depression (self-reported)	0.6	0.8	2.6	-0.3	-1.6	-1.0	-1.0	0.4	-0.2	-0.6
Breastfed as a baby	0.6	0.8	1.5	1.2	1.2	0.5	0.5	0.8	0.4	1.1
Birth weight of first child	0.6	1.2	2.5	-0.4	1.0	1.6	1.5	0.7	-1.2	0.5
Gout (self-reported)	0.6	0.9	1.8	1.3	0.5	-0.8	-0.8	-0.8	0.9	-1.1
Eye problems/disorders: None of the above	0.6	0.7	2.2	-0.7	0.9	-0.7	-0.6	-1.5	-0.7	-0.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.2	0.4	1.5	0.6	0.7	0.6	1.2	-0.2
Medication for pain relief, constipation, heartburn	0.6	0.9	2.3	0.3	0.5	1.5	1.4	1.2	0.8	0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.5	-1.2	0.6	1.2	1.1	0.2	-0.2	0.4
Knee pain experienced in last month	0.6	0.9	3.0	1.0	1.7	-0.2	-0.1	-1.2	-0.8	-0.2
Illnesses of siblings: Diabetes	0.6	0.8	2.8	1.7	1.3	0.3	0.4	0.1	0.7	0.4
Qualifications: nursing, teaching	0.6	0.9	1.4	-0.5	-0.8	-1.1	-1.0	-0.7	-1.2	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.2	0.5	-0.4	-0.8	-0.5	1.0	1.0	-1.8
Medication: Lisinopril	0.6	0.8	2.0	1.0	-0.5	-0.9	-0.8	0.9	0.3	1.4
Alcohol drinker status: Never	0.6	0.8	3.9	-0.3	-2.0	-0.6	-0.7	-0.1	-0.7	0.3
Number of operations (self-reported)	0.6	0.8	2.4	-1.4	-1.5	0.5	0.4	0.4	-0.1	-1.0
Diastolic blood pressure, automated reading	0.6	1.8	4.4	0.9	0.1	-2.1	-2.1	-0.5	1.7	-0.0
Vascular/heart problems diagnosed by doctor	0.6	1.5	4.2	-2.0	0.8	1.6	1.6	-0.2	-0.7	-0.2
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.7	-1.0	0.0	1.3	1.3	-0.4	-0.7	-0.3
Bipolar Disorder or Schizophrenia	0.5	1.1	2.6	-0.3	-0.0	1.6	1.5	1.4	-0.6	0.8
Depressed Affect (Nagel 2018)	0.5	1.0	1.9	1.2	-0.9	-0.1	-0.2	1.4	1.2	-1.3
Schizophrenia vs Biploar Disorder	0.5	0.7	1.9	0.0	-1.1	-0.9	-0.8	-1.4	-0.3	-0.3
Number of treatments/medications taken	0.5	0.9	2.2	0.9	-0.1	-1.5	-1.4	-0.7	-0.3	-0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.8	1.3	-0.8	-1.0	-1.0	-0.6	0.0	-0.5
Ever had hysterectomy (womb removed)	0.5	0.6	1.3	0.3	1.2	-1.0	-0.8	-0.4	-0.1	-0.9
Angina	0.5	0.7	1.3	-0.7	-0.6	-0.7	-0.5	-1.1	-1.1	-0.8
Medication: Metformin	0.5	0.7	2.0	-0.4	0.9	1.4	1.4	0.0	-0.1	0.1
Impedance of leg (right)	0.5	2.4	5.9	0.7	-1.7	-2.4	-2.2	0.5	-1.0	-1.2
Fed-up feelings	0.5	0.8	1.5	0.0	0.1	1.2	1.1	1.1	1.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.6	0.5	-1.2	-0.7	-0.8	0.2	-0.8	-1.0
Impedance of leg (left)	0.5	2.4	6.0	0.9	-1.7	-2.5	-2.3	0.4	-0.7	-0.9
Allergy	0.5	1.1	1.8	-0.2	1.4	1.1	1.2	-0.2	1.3	1.1
Illnesses of siblings	0.5	0.7	1.1	-0.9	-0.9	0.0	-0.2	-1.0	-1.0	-1.0
Alcohol intake versus 10 years previously	0.5	0.8	4.6	0.5	-2.1	-0.3	-0.5	-0.2	-0.3	-0.2
Mouth/teeth dental problems: Dentures	0.5	0.8	1.5	0.5	0.5	1.1	1.2	1.1	0.7	0.7
Medication: Cholesterol lowering	0.5	0.8	2.2	0.3	-0.1	-1.5	-1.4	-0.9	-0.4	-0.8
Lung cancer (father)	0.5	0.6	2.2	-1.5	-0.3	0.9	0.6	0.4	0.0	-0.6
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.6	-0.6	-1.3	-1.0	-0.9	0.2	-0.9	-0.2
Number of full brothers	0.5	0.6	3.0	-1.7	0.3	0.3	0.2	-0.0	-0.4	-0.8
Angina (self-reported)	0.5	0.7	1.3	-0.9	-0.6	-0.7	-0.5	-0.9	-1.1	-0.8
Overall health rating	0.5	1.0	2.5	1.6	-0.3	-1.3	-1.1	-0.4	0.7	-1.0
Medication for cholesterol	0.5	0.7	2.3	-0.8	-1.1	-0.1	-0.1	-0.6	-1.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	0.0	-0.9	-0.8	-0.8	0.8	1.1	-0.4
Hearing aid user	0.5	0.5	2.3	0.7	0.0	0.3	0.1	-0.7	-1.5	0.5
Medication: Atorvastatin	0.5	0.6	2.2	-0.0	-0.0	0.7	0.8	1.5	1.0	0.2
Irritability	0.5	0.8	2.7	1.1	0.3	-0.0	-0.1	-1.7	-1.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	2.6	0.5	0.6	-0.4	-0.3	1.6	1.1	0.0
Schizophrenia (2018)	0.4	0.7	2.3	1.5	-0.2	0.6	0.6	1.0	0.2	1.1
Worry (Nagel 2018)	0.4	0.8	1.8	0.3	-1.4	-0.5	-0.6	1.3	0.0	-1.2
Alzheimer’s Disease (in mother)	0.4	0.5	0.8	0.8	0.7	0.6	0.6	-0.9	-0.7	-0.5
Reaction Time	0.4	0.7	3.0	0.4	0.2	0.3	0.3	1.7	1.0	0.8
Coronary Artery Disease (CAD)	0.4	0.5	1.2	-0.6	0.1	-0.8	-0.7	-0.6	1.1	0.4
LDL Cholesterol	0.4	0.6	1.5	0.4	-0.6	-1.2	-1.1	0.1	0.6	-0.9
Primary Biliary Cirrhosis	0.4	0.6	0.9	0.9	0.7	0.9	0.8	0.5	1.0	0.1
Rheumatoid Arthritis	0.4	0.6	2.6	-1.1	-0.1	0.1	0.1	0.1	0.1	-1.6
Smoking Status	0.4	0.9	2.1	1.3	1.4	0.8	0.9	0.8	0.7	0.3
Hypothyroidism (self reported)	0.4	1.0	2.0	1.0	-0.9	-1.2	-1.2	0.4	1.4	-0.3
Chronotype (morning person)	0.4	0.9	3.1	-1.6	0.3	0.4	0.4	-1.8	-0.6	0.1
Trunk fat percentage	0.4	1.5	5.6	-0.6	0.7	-0.5	-0.4	-1.5	-1.4	-2.4
Taking other prescription medications	0.4	0.6	1.4	0.8	0.0	-1.0	-0.9	0.1	0.3	-1.2
Medication: Atenolol	0.4	0.5	1.4	-0.3	1.1	0.2	0.3	-1.2	-0.4	-0.8
Trunk fat mass	0.4	1.6	5.3	-0.7	1.1	-0.1	-0.0	-1.7	-1.1	-2.3
Number of incorrect matches in round	0.4	0.6	2.2	-1.0	0.3	-0.5	-0.4	0.5	1.5	-0.8
Pain all over the body in last month	0.4	0.4	0.7	-0.7	-0.4	0.9	0.6	-0.5	-0.8	-0.1
Neuroticism score	0.4	0.7	2.2	1.2	-0.9	-0.5	-0.6	0.2	0.4	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.4	1.2	1.1	0.6	0.5	0.2	-0.7	-0.9
Falls in the last year	0.4	0.6	1.8	0.2	0.0	-0.3	-0.3	-1.0	-1.3	-0.9
High blood pressure (siblings)	0.4	0.6	1.1	1.1	-0.5	-1.0	-0.9	0.5	0.5	0.4
Body fat percentage	0.4	1.5	6.6	-0.1	0.4	-0.8	-0.7	-1.3	-1.0	-2.6
Leg fat percentage (right)	0.4	1.3	5.7	0.4	-0.1	-1.2	-1.1	-0.9	-0.4	-2.4
Qualifications: College or University degree	0.4	1.2	2.1	-0.5	-1.0	-1.0	-1.1	-1.1	-1.5	-1.2
Heart disease (mother)	0.4	0.5	2.1	1.4	-0.7	-0.3	-0.5	0.7	-0.3	0.3
Whole body fat mass	0.4	1.8	6.3	-0.6	0.8	-0.3	-0.3	-2.0	-1.1	-2.5
Pulse rate, automated reading	0.4	1.3	3.5	1.0	-0.2	-1.9	-1.7	-0.7	1.0	-0.1
Comparative height size at age 10	0.4	2.5	8.4	-1.1	2.9	1.8	1.9	0.2	0.9	-0.2
Number of full sisters	0.4	0.5	1.4	1.2	-0.1	-0.7	-0.8	0.6	0.5	-0.6
Illnesses of father: Heart disease	0.4	0.6	1.3	-0.1	0.6	0.9	0.9	0.6	-0.6	1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.5	1.2	0.1	1.0	0.7	0.2	0.6	0.1
Miserableness	0.4	0.7	2.1	1.0	-0.2	0.2	0.2	1.3	0.4	-1.4
Financial situation satisfaction	0.4	0.4	2.9	1.7	0.2	-0.2	-0.1	-0.1	0.1	0.2
Commuting to job workplace: Public transport	0.4	0.5	1.8	0.4	0.4	0.6	0.5	0.7	1.3	0.8
Medication: Bendroflumethiazide	0.4	0.7	1.7	1.3	0.0	-0.8	-0.7	-0.2	0.4	1.3
Neuroticism (Nagel 2018)	0.3	0.8	1.9	1.4	-0.7	-0.1	-0.3	0.8	0.9	-1.3
Breast Cancer	0.3	0.7	1.1	-0.8	-0.4	-0.9	-1.0	-1.1	-1.0	0.3
Schizophrenia (2014)	0.3	0.6	1.6	0.1	0.1	1.3	1.2	0.6	-0.6	0.5
BMI	0.3	1.8	4.0	-0.9	1.9	1.0	1.1	-2.0	-0.4	-1.3
Neuroticism	0.3	0.7	2.9	0.4	-0.9	-0.6	-0.6	0.6	0.2	-1.7
Hearing difficulty/problems: Yes	0.3	0.5	1.5	1.1	1.2	-0.0	0.0	0.6	-0.0	0.5
Relative age of first facial hair	0.3	0.6	1.9	0.1	0.2	1.4	1.4	-0.0	-0.6	0.4
Medication for hormone replacement therapy	0.3	0.4	1.3	-1.2	-0.3	-0.3	-0.4	-0.4	-0.3	0.8
Diabetes (father)	0.3	0.4	0.8	0.3	-0.5	-0.9	-0.8	-0.6	0.6	0.7
Leg fat-free mass (left)	0.3	1.6	3.5	-0.9	1.9	1.1	1.0	-1.8	-0.1	-1.2
Leg predicted mass (left)	0.3	1.6	3.5	-1.0	1.8	1.0	0.9	-1.9	-0.2	-1.3
Waist circumference	0.3	1.3	4.4	0.4	1.1	-0.4	-0.3	-1.7	-0.3	-2.1
Nervous feelings	0.3	0.5	2.8	0.4	-0.4	-0.5	-0.3	0.3	-0.5	-1.7
Had other major operations	0.3	0.4	1.1	1.1	-0.1	-0.5	-0.3	1.1	0.6	-0.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	0.2	-0.5	0.8	0.9	0.7	-0.0	0.4
Fluid intelligence score	0.3	0.5	2.3	1.5	0.6	-0.5	-0.3	-0.1	0.8	0.5
Weight	0.3	1.5	4.5	-0.8	1.3	0.2	0.2	-1.9	-0.2	-2.1
Arm fat mass (right)	0.3	1.3	4.0	-0.5	1.1	0.5	0.5	-1.5	-0.8	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.1	-0.3	-0.8	-0.6	-0.8	-0.9	-0.3
Hair/balding pattern: Pattern 4	0.3	0.7	1.2	1.0	-0.3	-1.1	-0.9	1.0	0.9	-0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	2.7	1.6	-0.2	-0.0	-0.1	-0.2	0.4	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	-0.7	0.7	0.3	0.4	0.7	0.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.1	-0.8	0.7	1.0	0.9	-0.1	-0.3	0.1
Glaucoma (self-reported)	0.3	0.3	0.8	0.2	0.4	-0.9	-0.8	0.5	0.4	-0.5
Arm fat-free mass (right)	0.3	1.4	3.5	-1.8	0.8	0.2	0.1	-1.9	-0.1	-1.5
Medication: Blood pressure	0.3	0.5	1.0	1.0	-0.7	-0.7	-0.5	0.5	0.7	0.6
Medication: Ibuprofen	0.3	0.3	0.6	-0.4	-0.5	-0.8	-0.7	-0.6	0.3	0.6
Leg fat mass (right)	0.3	1.2	5.2	-0.1	0.6	-0.5	-0.4	-1.5	-0.6	-2.3
Chest pain or discomfort	0.3	0.4	2.2	1.5	-0.3	-0.1	-0.2	0.3	0.1	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.0	-0.3	-1.0	0.6	0.4	1.0	0.4	-0.3
Leg fat-free mass (right)	0.3	1.6	3.9	-0.8	2.0	1.2	1.1	-1.7	0.1	-1.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	-0.4	0.9	0.5	0.7	0.7	-0.5	-0.1
Ever had bowel cancer screening	0.3	0.4	0.8	-0.2	0.8	0.7	0.9	-0.3	-0.7	-0.3
Mineral and other dietary supplements	0.3	0.5	1.1	-0.2	-0.1	0.9	0.9	0.5	0.3	1.1
Osteoporosis (self-reported)	0.3	0.3	1.0	-0.6	-1.0	-0.0	-0.1	0.5	0.4	0.8
Medication: Aspirin	0.3	0.5	1.2	-0.8	0.1	-0.7	-0.6	-0.6	0.2	-1.1
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	0.8	-0.0	-0.6	-0.7	-0.7	-0.0	-0.5
Leg predicted mass (right)	0.3	1.6	4.0	-0.7	2.0	1.4	1.2	-1.6	0.2	-0.9
Arm fat mass (left)	0.3	1.4	4.9	-1.0	1.0	0.3	0.3	-1.5	-0.9	-2.2
Basal metabolic rate	0.3	1.5	3.2	-1.0	1.7	0.8	0.7	-1.8	-0.0	-1.5
Leg fat percentage (left)	0.3	0.9	3.8	0.5	0.2	-1.0	-0.9	-0.8	0.0	-1.9
Unable to work because of sickness or disability	0.3	0.5	0.9	0.3	-0.7	0.4	0.4	1.0	1.0	-0.6
Commuting to job workplace: Cycle	0.3	0.4	1.6	1.0	0.1	-0.0	-0.1	0.3	1.3	0.4
Pain experienced in last month	0.3	0.5	0.9	-1.0	-0.4	0.9	0.9	0.8	0.6	-0.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	0.1	-0.1	0.6	0.7	0.6	0.8	0.6
Leg fat mass (left)	0.3	1.1	4.6	-0.3	0.7	-0.3	-0.3	-1.5	-0.4	-2.1
Ovarian Cancer	0.2	0.2	0.5	0.2	0.4	-0.7	-0.7	0.1	-0.1	0.6
Crohns Disease (2012)	0.2	0.3	0.7	-0.8	-0.0	-0.2	-0.2	0.8	-0.5	0.3
Neuroticism (2016)	0.2	0.2	1.1	0.2	-1.0	0.4	0.3	0.6	0.1	-0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.1	1.1	0.3	-0.1	-0.1	0.1	-0.7	0.4
Height	0.2	3.3	18.2	-1.0	4.3	1.2	1.4	0.4	0.6	-0.4
Systolic Blood Pressure	0.2	1.1	2.3	-0.6	0.9	-1.4	-1.5	0.1	-1.4	-0.1
Systolic blood pressure, automated reading	0.2	0.6	1.5	-0.8	1.2	-0.8	-0.9	-0.2	-0.5	-0.3
Age when periods started (menarche)	0.2	0.4	1.3	1.1	-0.8	-0.3	-0.3	-0.3	0.9	0.1
Body mass index (BMI)	0.2	0.8	2.7	-0.4	0.5	0.1	0.0	-1.5	-0.3	-1.6
Medication: Ramipril	0.2	0.3	1.0	-0.8	-0.0	-0.4	-0.4	0.4	0.1	-1.0
Medication: Simvastatin	0.2	0.3	0.8	0.2	0.6	-0.9	-0.8	-0.5	0.1	-0.3
Arm fat percentage (right)	0.2	1.0	4.4	-0.2	0.8	0.2	0.2	-1.0	-0.7	-2.1
Trunk fat-free mass	0.2	1.2	2.4	-1.0	1.5	1.1	1.0	-1.3	0.4	-0.8
Hip circumference	0.2	0.9	1.7	-0.1	1.2	1.0	1.1	-0.1	1.0	-1.3
Pulse rate	0.2	0.3	1.0	0.3	-1.0	-0.1	0.1	0.6	0.7	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.7	0.5	-0.5	0.3	0.1	-0.4	-0.1	-1.7
Illnesses of mother	0.2	0.2	1.0	-1.0	-0.0	-0.2	-0.2	-0.4	0.2	-0.5
Trunk predicted mass	0.2	1.2	2.2	-1.0	1.5	1.1	1.0	-1.3	0.4	-0.9
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.3	-0.3	0.8	0.7	0.1	-0.3	0.6
Wheeze or whistling in the chest in last year	0.2	0.3	1.2	-0.7	0.5	0.2	0.3	0.3	-0.5	-1.1
Age at first live birth	0.2	0.4	0.9	-0.2	-0.6	-0.7	-0.8	-0.9	0.2	0.1
Arm predicted mass (right)	0.2	0.9	1.6	-1.2	1.0	0.7	0.5	-1.3	0.6	-1.2
Medication: Aspirin	0.2	0.3	0.9	-0.6	0.2	-0.6	-0.4	-0.3	0.2	-1.0
Whole body fat-free mass	0.2	1.4	2.9	-1.0	1.7	1.1	0.9	-1.6	0.3	-1.1
Arm fat percentage (left)	0.2	1.0	4.9	-0.4	0.6	0.1	0.1	-1.0	-0.7	-2.2
Diabetes diagnosed by doctor	0.2	0.4	1.2	-0.3	0.2	-0.7	-0.6	-1.1	-0.2	-0.6
Commuting to job workplace: Walk	0.2	0.2	0.7	0.6	0.8	-0.1	-0.0	-0.2	-0.8	-0.2
Whole body water mass	0.2	1.4	2.9	-1.1	1.7	1.1	1.0	-1.6	0.1	-1.0
Ever taken oral contraceptive pill	0.2	0.3	0.8	0.6	0.9	-0.5	-0.4	-0.1	0.3	0.1
Mother’s age at death	0.2	0.3	0.7	0.1	-0.8	-0.2	-0.1	-0.7	-0.9	-0.3
High cholesterol (Self-reported)	0.2	0.3	0.6	0.8	0.3	-0.7	-0.7	0.5	-0.4	0.2
Arm fat-free mass (left)	0.2	1.0	2.3	-0.9	1.2	0.5	0.4	-1.5	0.3	-1.3
Average weekly beer plus cider intake	0.2	0.3	0.6	0.6	0.7	0.1	0.0	-0.5	-0.2	0.8
Cholesterol lowering medication	0.2	0.2	0.7	0.8	0.6	-0.5	-0.3	0.3	-0.1	-0.4
Supplements: Calcium	0.2	0.2	0.6	-0.7	-0.8	-0.2	-0.3	-0.2	0.1	-0.2
Impedance of whole body	0.2	0.9	2.1	0.8	-0.7	-1.4	-1.2	0.8	-0.8	-0.7
Arm predicted mass (left)	0.2	1.2	2.8	-1.2	1.4	0.6	0.5	-1.7	0.1	-1.2
Average weekly spirits intake	0.1	0.2	0.7	0.8	-0.6	-0.1	-0.0	-0.3	-0.0	-0.0
Supplements: Zinc	0.1	0.1	0.4	0.1	-0.2	-0.5	-0.4	0.6	-0.0	0.0
Current tobacco smoking	0.1	0.2	0.5	0.6	0.5	0.2	0.3	0.4	-0.7	0.2
Sitting height	0.1	0.6	2.6	-0.2	1.2	0.3	0.2	0.0	1.6	-0.3
High blood pressure (mother)	0.1	0.1	0.3	0.3	-0.5	0.4	0.1	0.5	-0.4	0.1
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	0.7	-0.5	-0.0	0.0	0.1	0.2	0.5
Impedance of arm (right)	0.1	0.5	1.8	1.3	0.1	-0.0	0.2	1.2	-0.5	0.1
Impedance of arm (left)	0.1	0.3	1.7	0.6	0.2	-0.0	0.2	1.3	-0.5	-0.0
Standing height	0.1	1.2	4.2	-1.1	2.0	0.8	0.8	-1.0	-0.0	-1.0
Migraine (self-reported)	0.1	0.1	0.3	-0.1	-0.4	-0.5	-0.3	-0.1	-0.6	0.5
Suffer from ‘nerves’	0.1	0.2	0.3	0.6	-0.1	0.5	0.5	0.3	-0.3	-0.4
Smoking status: Current	0.1	0.2	0.7	0.9	0.4	0.0	0.2	0.2	-0.6	-0.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.3	-0.2	0.3	-0.5	-0.4	0.6	0.2	-0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.7	2.0	-1.4	0.7	1.0	1.1	0.5	0.1	0.2
Tanning	0.0	0.3	0.6	-0.8	-0.1	0.2	0.1	0.7	0.8	0.4

Hub : Genes

MPP2

Models

Trait associations