Hub : Genes

MPZ

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1250	0.0370	7.3e-05	0.095	0.048	0.103	0.100	0.114	1.4e-11	1.6e-06	1.8e-12	3.6e-12	9.6e-14
2	GTEx	Nerve Tibial	0.1248	0.0511	6.0e-03	0.036	NA	0.018	NA	0.024	1.4e-03	NA	1.9e-02	NA	7.8e-03
3	GTEx	Testis	0.2360	0.0700	1.6e-04	0.052	NA	0.035	NA	0.084	2.5e-03	NA	1.1e-02	NA	1.4e-04
4	NTR	Blood	0.0303	0.0115	1.2e-03	0.000	0.002	0.000	0.001	-0.001	4.4e-01	4.8e-02	5.1e-01	1.0e-01	5.7e-01
5	TCGA	Brain Lower Grade Glioma	0.0849	0.0349	9.5e-05	0.020	0.030	0.015	NA	0.025	2.0e-03	1.9e-04	6.3e-03	NA	7.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.2	0.3	0.8	-0.0	0.9	-0.3	0.1	-0.9
Bipolar Disorder or Schizophrenia	0.2	0.6	2.0	-0.4	-0.5	0.4	1.4	-0.6
Depressed Affect (Nagel 2018)	1.0	2.1	3.5	-1.9	-0.7	1.8	0.9	-1.6
Depression (Nagel 2018)	1.0	1.5	2.2	-1.0	-1.4	1.0	1.5	-1.2
Intelligence (Savage-Jansen 2018)	0.5	1.4	6.1	0.2	-0.1	-2.5	0.4	-0.9
Neuroticism (Nagel 2018)	1.1	2.5	6.9	-1.2	-1.4	2.6	1.5	-0.5
Schizophrenia (2018)	0.4	0.8	3.0	-0.5	-0.5	0.7	1.7	-0.0
Schizophrenia vs Biploar Disorder	0.8	1.1	2.6	-1.6	0.0	0.8	-1.1	1.0
Worry (Nagel 2018)	1.0	2.0	6.8	-0.8	-1.2	2.6	1.1	-0.1
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	0.8	0.1	-0.4	1.0	-1.0
Alzheimer’s Disease (in father)	0.7	0.8	2.3	1.5	-0.6	1.0	-0.4	0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	3.3	1.8	-0.1	0.5	1.0	-0.7
Crohns Disease (2017)	1.1	2.4	9.9	0.4	0.9	1.1	-3.1	0.3
Irritable Bowel Disease (IBD)	1.1	2.7	11.0	-0.0	1.3	0.8	-3.3	0.0
Ulcerative Colitis (UC)	0.6	1.1	4.8	-0.1	0.7	0.3	-2.2	-0.1
Major Depression (MDD)	0.1	0.1	0.4	-0.1	-0.6	-0.1	0.6	-0.1
Reaction Time	0.5	0.9	2.2	1.1	-0.8	1.5	-0.1	0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.1	4.3	-0.1	-0.7	-2.1	0.2	-0.9
Breast Cancer	0.3	0.7	2.4	0.6	-0.4	-1.6	0.7	0.4
Ovarian Cancer	1.2	1.6	6.4	0.3	0.7	0.6	-2.5	0.8
Prostate Cancer	1.4	2.0	5.8	-2.4	1.3	0.0	0.8	-1.4
Age at First Birth	0.1	0.1	0.3	-0.4	-0.0	0.4	0.0	0.5
Bipolar Disorder (2011)	0.2	0.2	0.8	0.3	0.0	0.3	-0.9	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.1	-0.9	0.1	-0.5	0.6
Coronary Artery Disease (CAD)	0.2	0.2	0.6	0.5	-0.3	0.7	0.0	-0.2
Crohns Disease (2012)	1.6	2.6	4.8	-0.2	1.4	1.4	-2.1	2.2
Mean Putamen Volume	2.0	2.3	5.9	1.6	-0.5	0.1	-2.4	1.7
Fasting Glucose	0.5	0.7	1.3	-0.9	-1.2	0.9	-0.4	0.2
HbA1C	2.1	2.3	7.3	-0.0	-0.6	1.9	-2.7	0.6
HDL Cholesterol	0.5	0.8	2.0	0.2	-0.1	-1.4	-0.4	-1.4
LDL Cholesterol	0.5	0.8	3.6	0.0	-1.9	0.5	-0.2	-0.2
Lupus	0.8	1.2	4.0	-0.6	0.6	-1.0	2.0	0.2
Neuroticism (2016)	0.8	1.1	3.6	-0.8	-0.7	1.9	0.6	-0.7
Primary Biliary Cirrhosis	1.0	1.4	3.6	0.3	-1.9	-0.9	0.9	-1.4
Rheumatoid Arthritis	2.9	3.9	11.0	1.5	-3.3	-0.1	-2.3	1.1
Schizophrenia (2014)	0.3	0.6	1.5	0.4	0.1	1.0	1.2	0.5
Triglycerides	0.3	0.5	1.4	-0.1	-0.4	0.1	-1.0	1.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.4	-0.2	-0.9	-0.8	-1.2	-1.8
Ulcerative Colitis	1.5	2.1	5.8	0.3	2.4	1.1	-1.5	1.1
Blood Eosinophil Count	0.3	2.2	5.3	-2.3	1.2	-1.8	0.8	-0.5
Blood Platelet Count	0.6	7.3	16.7	0.9	3.9	1.8	-4.1	0.4
Blood Red Count	0.9	8.6	18.0	3.1	-2.1	-1.4	-4.2	3.0
Blood White Count	1.4	10.6	33.9	-0.5	3.0	2.0	-5.8	2.5
Heel T-Score	0.3	2.4	5.3	1.1	0.2	2.2	-0.8	2.3
BMI	0.2	1.3	2.9	-0.7	1.4	-1.0	-1.7	-0.4
Height	0.2	2.9	8.0	-2.1	2.8	-0.8	1.2	0.2
Waist Hip Ratio (WHR)	0.3	1.2	4.2	2.1	-0.5	0.8	0.6	0.6
Systolic Blood Pressure	0.2	0.9	3.1	0.1	-1.1	0.1	0.4	1.8
Smoking Status	1.7	4.2	7.7	-2.8	1.0	-1.1	2.1	-2.6
Allergy or Eczema	0.9	2.3	4.1	1.9	-1.1	-2.0	-1.3	0.8
Cardiovascular Disease	0.1	0.3	1.0	-0.1	0.2	0.8	-0.0	1.0
Hypothyroidism (self reported)	0.8	1.8	4.2	2.1	1.1	-0.0	-1.2	1.4
Respiratory disease	2.7	6.1	12.2	3.5	-2.5	-1.2	-2.2	2.4
Type 2 Diabetes (T2D) (2018)	1.5	2.9	6.2	1.7	-0.8	2.5	-1.5	1.4
Lung FEV1/FVC ratio	1.6	7.9	18.4	-4.3	1.9	-0.2	-0.7	-4.1
Lung FVC	1.2	5.9	15.2	-1.4	-1.9	-1.8	2.2	-3.9
Neuroticism	1.1	2.6	7.7	-1.4	-1.1	2.8	1.2	-0.8
Chronotype (morning person)	0.1	0.3	0.8	0.3	-0.7	0.1	-0.1	0.9
Hair Pigment	0.1	1.9	4.6	-1.7	0.4	-1.1	0.7	-2.1
Tanning	0.1	0.8	3.0	0.4	-0.7	-0.2	-0.3	1.7
Hand grip strength (left)	0.1	0.3	0.6	-0.7	-0.8	-0.5	-0.5	0.2
Number of treatments/medications taken	1.7	3.1	7.2	2.7	-2.2	0.1	-0.1	1.7
Average weekly spirits intake	0.4	0.5	2.0	-0.3	-1.4	-0.1	0.5	-0.3
Sensitivity / hurt feelings	0.7	1.2	5.2	-0.3	0.6	0.6	2.3	0.5
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.3	-0.2	-1.5	1.8	0.9	-0.0
Hearing difficulty/problems: Yes	0.4	0.7	1.4	-1.2	0.6	-0.7	-0.1	-1.0
Relative age of first facial hair	0.3	0.7	2.3	-0.0	1.0	1.5	-0.0	-0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.0	-0.0	0.7	0.1	0.6
Ever used hormone-replacement therapy (HRT)	0.5	0.7	2.1	-0.5	-0.4	-0.9	-0.1	-1.4
Ever had hysterectomy (womb removed)	1.4	1.6	3.9	0.8	-1.1	-2.0	1.4	0.5
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.1	-0.2	-0.9	0.7	0.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	-0.9	0.3	0.7	-0.1	0.0
Angina	2.2	2.9	7.0	2.6	-0.9	0.1	-0.7	2.5
Medication for hormone replacement therapy	0.5	0.5	1.1	-0.2	-0.5	-0.5	1.1	-0.9
Vitamin and mineral supplements	2.0	2.7	7.6	1.7	-1.2	-0.6	2.8	1.0
Supplements: Zinc	0.9	1.0	2.9	-0.7	0.9	-0.2	-1.7	-0.7
Medication: Co-codamol	0.1	0.2	0.7	0.0	-0.9	-0.1	-0.3	0.1
Medication: Metformin	0.9	1.2	3.0	1.2	-1.3	1.7	-0.3	0.2
Diabetes (father)	0.8	1.0	2.5	0.7	1.6	-0.3	1.3	-0.0
Diabetes (mother)	0.3	0.4	1.0	0.5	-1.0	0.6	-0.4	-0.1
Severe depression (siblings)	0.7	0.8	1.5	-0.3	-1.2	0.4	1.2	-0.8
Pack years adult smoking proportion	0.4	0.6	1.2	1.0	0.5	0.8	0.1	1.1
Impedance of leg (right)	1.0	4.7	11.6	3.4	-0.1	1.9	-0.5	2.8
Leg fat-free mass (left)	0.4	2.3	6.4	-2.5	1.6	-0.7	0.3	-1.3
Trunk fat percentage	0.3	1.2	2.4	1.5	0.9	-1.3	-1.1	0.3
Hand grip strength (right)	0.2	0.5	1.6	-1.3	0.5	-0.1	-0.5	0.6
Townsend deprivation index at recruitment	1.1	1.5	3.6	-0.9	-1.1	-0.6	1.9	-1.2
Current tobacco smoking	0.5	0.8	1.4	-0.6	0.6	-1.2	1.1	-0.8
Average weekly fortified wine intake	1.1	1.3	2.6	1.3	-0.7	-1.0	-1.0	1.6
Maternal smoking around birth	0.3	0.5	1.6	1.2	0.1	0.1	-0.8	-0.4
Fed-up feelings	1.1	2.0	3.0	-0.9	-1.2	1.7	1.7	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.7	-1.5	-0.4	1.0	0.0	-2.2
Relative age voice broke	0.9	1.3	4.7	-0.8	1.0	2.2	0.2	0.5
Taking other prescription medications	1.9	2.9	9.4	3.1	-0.9	-0.3	-0.4	2.0
Age when periods started (menarche)	0.6	1.4	3.3	0.9	1.0	1.8	-0.4	1.3
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.2	1.3	-1.5	-1.8	1.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.8	-0.4	1.3	1.0	-1.0	-0.1
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	-0.1	0.9	0.9	-0.7	-0.1
Qualifications: CSEs or equivalent	0.4	0.5	0.9	1.0	-0.5	0.7	-0.4	0.9
Serious illness, injury or assault to yourself	0.9	1.0	3.8	0.6	-2.0	0.6	0.7	-0.5
High blood pressure	0.2	0.4	0.8	0.7	0.5	0.8	0.2	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.8	1.3	-0.5	-1.0	-1.4	0.8
Multivitamins +/- minerals	1.2	1.5	7.1	-0.4	-0.5	-0.0	-2.7	-0.4
Stomach or abdominal pain in last month	1.2	1.4	3.4	1.1	1.8	0.3	-1.6	-0.3
Supplements: Glucosamine	1.0	1.3	4.6	1.2	0.6	0.2	-2.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.2	0.6	-0.8	-1.1	0.2	0.7
Medication: Atenolol	1.4	1.7	4.1	0.9	0.7	1.5	-2.0	1.0
Medication: Levothyroxine sodium	0.8	1.3	3.7	0.9	1.9	0.2	-1.2	0.9
Sitting height	0.1	0.5	1.4	-0.2	0.4	-0.2	1.2	1.1
Chronic bronchitis/emphysema (father)	0.5	0.6	1.3	1.2	-0.7	-0.9	-0.2	-0.5
High blood pressure (mother)	0.6	0.8	2.0	0.1	-1.1	-1.4	0.7	-0.7
Body mass index (BMI)	0.3	1.3	2.7	-0.4	0.8	-1.6	-1.0	-1.4
Impedance of leg (left)	0.8	3.8	11.0	3.3	-0.4	1.6	-0.2	2.3
Leg predicted mass (left)	0.4	2.3	6.4	-2.5	1.6	-0.7	0.3	-1.4
Trunk fat mass	0.3	1.1	1.9	0.7	1.4	-1.4	-1.1	0.1
Waist circumference	0.2	0.6	1.2	0.1	1.1	-1.0	-0.4	-0.7
Number of incorrect matches in round	0.7	1.2	2.3	-1.2	-1.1	1.0	-0.5	-1.5
Past tobacco smoking	1.1	1.9	4.5	2.1	0.2	0.4	-1.6	1.6
Alcohol usually taken with meals	2.3	3.7	8.1	2.3	0.7	0.5	-2.0	2.9
Nervous feelings	0.3	0.6	1.5	-0.4	-0.6	1.2	0.9	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	3.8	-0.4	-0.3	1.9	0.1	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.7	-0.1	0.6	1.3	-0.8	-0.3
Hair/balding pattern: Pattern 2	1.6	2.0	4.8	-2.2	0.4	-1.3	0.6	-1.7
Had menopause	1.0	1.2	2.9	-1.1	0.6	-1.3	0.3	-1.7
Had other major operations	0.2	0.2	0.4	0.4	0.5	-0.6	-0.2	0.6
Forced vital capacity (FVC)	0.9	3.3	6.8	-2.4	-0.6	-0.2	1.9	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.2	-0.1	0.2	-0.4	-1.5	-0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	0.9	-0.7	0.1	1.0	-0.4	-0.8
Qualifications: None of the above	0.1	0.2	0.3	0.6	-0.1	-0.1	-0.6	-0.5
Financial difficulties in last 2 years	1.4	1.9	3.6	1.2	-1.7	1.9	0.9	-0.8
Mouth/teeth dental problems	0.3	0.4	1.1	-0.4	-0.6	0.2	-1.1	0.5
Heart attack	1.0	1.3	2.4	0.6	-1.5	-0.0	1.2	1.5
Allergy	1.5	3.4	7.8	-2.8	1.8	0.4	1.9	-1.6
Pain all over the body in last month	0.7	0.7	1.4	0.9	0.2	1.2	-0.8	0.8
Diabetes (self-reported)	0.9	1.5	4.1	0.4	-1.1	2.0	-1.0	0.9
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	0.3	-0.7	-0.5	-0.5	0.4
Medication: Ramipril	0.8	1.0	3.2	1.8	-0.5	-0.3	-1.1	0.1
Medication: Simvastatin	0.5	0.7	1.1	0.4	-1.0	0.4	-1.0	0.9
Fluid intelligence score	0.4	0.9	3.4	0.1	-0.4	-1.8	0.8	0.5
Illnesses of siblings	0.3	0.4	1.3	-0.5	0.3	1.1	0.5	0.4
Neuroticism score	1.2	2.6	4.7	-1.9	-0.4	2.2	2.0	-0.8
Weight	0.3	1.2	2.2	-1.0	1.5	-1.3	-0.6	-0.9
Impedance of arm (right)	0.5	2.1	6.5	2.5	-1.2	0.6	0.8	1.3
Arm fat percentage (right)	0.3	1.0	2.7	0.6	0.5	-1.6	-0.9	-1.0
Trunk fat-free mass	0.5	3.1	9.4	-3.1	1.8	-0.9	0.3	-1.5
Hip circumference	0.3	1.4	3.2	-1.1	1.8	-1.0	-1.1	-0.8
Time employed in main current job	0.3	0.3	0.8	-0.4	0.7	0.3	-0.4	0.9
Alcohol intake versus 10 years previously	0.1	0.2	0.7	0.4	0.9	0.1	-0.0	-0.2
Father’s age at death	0.3	0.4	0.8	0.6	-0.6	-0.9	-0.4	-0.5
Worrier / anxious feelings	0.5	0.9	2.4	0.5	-0.7	1.6	1.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.2	2.0	4.2	1.5	-2.0	1.9	0.1	0.0
Falls in the last year	0.5	0.6	2.7	0.2	0.5	-0.4	-0.2	-1.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.3	-0.8	0.6	0.5	-0.7
Number of live births	2.1	2.9	8.3	-1.9	-0.9	0.1	1.4	-2.9
Forced expiratory volume in 1-second (FEV1)	1.8	5.9	14.2	-3.7	-0.4	-0.3	1.3	-3.8
Pulse rate	0.5	0.8	1.9	-1.4	0.6	1.1	0.1	-0.5
Happiness	1.6	2.0	3.5	-1.9	0.8	1.6	1.7	-0.5
Noisy workplace	0.4	0.4	1.5	-0.4	1.2	-0.7	-0.3	-0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	0.3	0.6	-1.4	0.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	0.9	-0.7	-0.2	0.3	0.3
Mouth/teeth dental problems: Dentures	0.3	0.4	0.9	-0.3	-0.6	-1.0	-0.8	0.3
Asthma	3.2	6.3	9.7	3.1	-3.0	-1.0	-2.8	1.9
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.5	1.1	0.4	-0.6	-1.2	0.1
Medication: Cholesterol lowering	0.4	0.7	1.3	1.1	-0.6	1.1	0.3	0.6
Depression (self-reported)	0.6	0.7	3.0	0.3	-0.3	1.7	0.3	0.6
Medication: Lansoprazole	0.6	0.7	1.6	1.3	-0.9	0.7	0.3	-0.7
Prospective memory result	0.6	0.8	1.4	0.4	-1.2	1.0	-1.1	0.3
Lung cancer (father)	0.5	0.5	1.7	-0.0	1.3	0.9	-0.4	-0.3
Illnesses of mother	1.2	1.5	4.0	-2.0	-0.0	1.6	0.7	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.8	13.7	-3.5	0.1	-0.1	1.7	-3.7
Pulse wave Arterial Stiffness index	0.0	0.1	0.1	-0.1	0.3	0.1	0.4	0.1
Impedance of arm (left)	0.5	2.2	6.7	2.6	-0.9	0.5	0.3	1.8
Arm fat mass (right)	0.4	1.5	3.4	-0.2	1.3	-1.9	-0.9	-1.2
Trunk predicted mass	0.5	3.0	9.3	-3.0	1.7	-0.9	0.3	-1.5
Standing height	0.1	1.3	3.5	-1.1	1.9	0.2	0.9	1.1
Length of working week for main job	0.3	0.3	1.0	-0.3	-1.0	-0.4	-0.2	-0.5
Exposure to tobacco smoke at home	1.9	2.2	6.0	-1.8	0.4	-0.7	1.1	-2.5
Breastfed as a baby	0.7	0.8	3.5	-0.6	-0.5	-1.9	0.1	-0.4
Tense / ‘highly strung’	1.1	1.9	5.8	-0.1	-0.7	2.4	1.1	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	3.5	1.3	-1.9	1.0	1.3	1.3
Hair/balding pattern: Pattern 4	1.5	3.6	7.9	2.8	0.6	-1.3	-0.2	2.8
Birth weight of first child	1.5	2.6	11.6	-0.9	3.4	0.8	0.1	0.2
Peak expiratory flow (PEF)	2.0	4.6	12.5	-2.7	-1.0	-1.3	0.7	-3.5
Pulse wave reflection index	1.1	1.3	2.7	-0.2	-0.6	-1.6	1.4	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	0.1	-0.2	1.1	-0.7	-0.5
Loud music exposure frequency	2.5	2.8	6.3	-2.5	1.6	-0.5	1.0	-1.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	1.5	0.7	-0.3	0.4	0.9
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	10.3	-0.8	-0.3	-0.6	3.2	-2.0
Blood clot in the leg (DVT)	1.5	1.9	4.5	0.1	-2.1	1.9	1.3	0.1
Medication: Paracetamol	0.2	0.4	0.9	0.7	-0.7	1.0	-0.1	-0.3
Headache pain in last month	1.5	2.6	5.8	0.7	1.9	0.7	-2.4	-1.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.1	-0.7	0.6	-0.9	-1.0	-1.1
Glaucoma (self-reported)	0.6	0.7	1.9	-0.1	0.2	0.2	1.4	1.3
Gout (self-reported)	1.0	1.4	3.2	0.4	1.8	0.1	-1.1	1.4
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.1	2.0	1.9	0.1	-0.8	1.0
Medication: Amlodipine	0.6	0.8	2.4	0.1	-1.6	0.2	0.6	-1.1
Medication: Ventolin 100micrograms inhaler	2.7	3.5	11.1	1.6	-1.4	1.2	-3.3	0.5
Birth weight	1.2	2.7	8.2	-2.0	2.9	1.0	-0.2	0.1
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.6	0.7	1.3	-0.6	-0.2	-0.0
High blood pressure (siblings)	0.5	0.7	2.4	0.6	-1.6	-0.4	-0.8	-0.1
Forced vital capacity (FVC), Best measure	0.9	3.2	6.8	-2.2	-0.3	-0.6	2.0	-2.6
Body fat percentage	0.3	1.4	2.7	1.6	0.9	-1.1	-1.5	0.3
Leg fat percentage (right)	0.5	1.7	3.9	2.0	0.7	-0.7	-1.9	0.4
Arm fat-free mass (right)	0.4	2.0	5.6	-2.4	1.7	-0.6	0.3	-0.9
Exposure to tobacco smoke outside home	0.9	1.1	4.1	0.0	0.2	2.0	1.3	0.0
Comparative body size at age 10	0.7	2.0	5.2	-1.4	2.3	-0.8	-0.2	-1.5
Number of full brothers	0.7	0.8	1.7	-0.6	-1.3	0.5	0.9	-1.0
Worry too long after embarrassment	0.8	1.3	2.9	-0.3	-0.8	1.6	1.7	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.7	3.5	7.3	0.9	-2.7	2.0	2.1	1.1
Wheeze or whistling in the chest in last year	0.6	1.1	3.3	-0.1	1.5	0.3	-1.8	-0.3
Number of children fathered	0.8	0.9	2.3	0.2	1.1	0.4	-1.5	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.0	-0.6	-0.7	0.1	1.4	-0.2
Age at first live birth	0.8	1.4	3.0	-0.5	1.5	1.1	0.7	1.7
Pulse wave peak to peak time	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.1
Health satisfaction	0.4	0.5	0.9	-0.9	-0.2	0.5	0.9	-0.7
Shortness of breath walking on level ground	0.4	0.4	1.2	0.5	-0.7	1.1	-0.6	-0.0
Qualifications: College or University degree	0.6	1.8	3.5	0.3	1.7	-0.4	-1.9	1.6
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	-0.1	0.3	-0.2	-0.3
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.0	-0.4	-0.4	-2.0	-0.7	-1.3
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.4	-0.4	-0.6	0.8	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.8	3.3	-1.8	0.2	-0.2	0.8	-0.3
Neck or shoulder pain in last month	0.5	0.7	1.6	-0.2	0.2	1.0	-0.8	-1.3
Medication: Blood pressure	0.7	1.2	2.2	1.4	-0.9	0.9	-0.4	1.5
Angina (self-reported)	1.6	2.2	5.3	2.2	-0.6	-0.0	-0.6	2.3
Migraine (self-reported)	1.0	1.2	3.9	-1.2	2.0	-0.2	0.8	-0.2
Medication: Ibuprofen	0.5	0.6	1.7	1.3	-0.8	-0.3	-0.9	0.0
Medication: Allopurinol	0.8	1.1	2.7	0.8	1.6	0.3	-0.5	1.3
Medication: Omeprazole	1.2	1.5	3.6	1.9	0.5	1.3	-1.1	0.7
Medication: Seretide 50 evohaler	0.9	1.0	2.0	-0.5	-1.3	-0.3	1.4	-0.9
Mean time to correctly identify matches	0.6	1.1	3.3	1.8	-0.6	0.6	-0.8	0.9
Heart disease (mother)	0.8	1.0	2.8	0.7	1.1	-1.7	-0.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.3	-0.3	-0.8	0.5	-1.1	0.2
Whole body fat mass	0.2	0.9	1.7	0.4	1.3	-1.1	-1.2	-0.2
Leg fat mass (right)	0.2	0.9	2.4	0.6	1.3	-0.5	-1.6	-0.2
Arm predicted mass (right)	0.4	1.8	5.7	-2.4	1.5	-0.5	0.2	-1.0
Pulse rate, automated reading	0.3	0.8	2.2	-0.1	1.5	-0.2	1.2	-0.7
Alcohol intake frequency.	0.1	0.3	1.4	-0.1	-0.0	-0.2	-0.4	-1.2
Comparative height size at age 10	0.1	0.3	1.1	-0.2	0.5	-0.4	-0.3	1.1
Number of full sisters	0.5	0.6	2.3	0.3	-1.5	0.4	0.2	0.7
Suffer from ‘nerves’	0.6	0.9	2.0	1.4	-0.5	1.0	-0.4	1.2
Overall health rating	0.4	0.8	2.1	1.5	-0.2	0.9	0.7	0.7
Chest pain or discomfort	0.8	1.2	2.5	1.2	-0.8	0.8	0.6	1.6
Had major operations	0.3	0.4	0.8	0.1	-0.9	0.3	-0.8	0.7
Age at last live birth	0.8	1.2	1.7	-0.9	1.1	0.7	1.2	1.3
Family relationship satisfaction	0.5	0.6	1.7	1.2	0.2	0.3	1.3	0.1
Leg pain on walking	0.5	0.7	2.2	1.0	-0.4	1.5	-0.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.4	-1.2	-1.1	-0.1	0.4	-1.1
Commuting to job workplace: Car/motor vehicle	1.1	1.3	5.3	0.3	-0.1	1.0	-2.3	0.0
Illness, injury, bereavement, stress in last 2 years	2.5	3.1	9.4	-1.9	3.1	-1.4	0.2	0.5
Medication: Aspirin	0.7	0.9	1.9	1.0	-0.7	-0.7	-1.4	0.7
Supplements: Vitamin C	1.0	1.1	3.1	0.7	0.7	0.4	-1.7	1.2
Knee pain experienced in last month	1.5	2.4	5.0	2.2	-1.5	0.7	-1.7	1.2
Hypertension (Self-reported)	0.1	0.4	0.6	0.6	0.4	0.8	0.5	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.8	1.0	-0.1	-0.6	-1.4	0.2
Illnesses of father: Heart disease	0.7	1.0	1.9	1.2	-1.4	-0.1	-0.8	1.1
Illnesses of siblings: Diabetes	0.3	0.4	1.0	0.5	1.0	0.6	-0.0	0.4
Smoking status: Previous	0.9	1.3	4.1	-2.0	-0.3	0.3	0.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.5	-1.2	0.4	0.6	0.0	0.0
Whole body fat-free mass	0.5	3.0	8.9	-3.0	1.7	-0.8	0.3	-1.5
Leg fat-free mass (right)	0.5	2.5	7.0	-2.6	1.3	-0.8	0.4	-1.8
Arm fat percentage (left)	0.2	0.9	1.8	0.8	0.6	-1.3	-1.2	-0.6
Average weekly red wine intake	0.3	0.5	2.0	-0.4	0.3	-1.4	-0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.5	-0.2	0.6	0.3	-0.7	-0.3
Mood swings	1.0	1.8	4.2	-1.5	-0.1	2.0	0.2	-1.5
Loneliness, isolation	1.5	2.1	6.6	-1.4	1.0	2.6	0.9	-0.0
Long-standing illness, disability or infirmity	0.8	1.3	3.5	1.3	-0.9	0.4	-0.2	1.9
Ever had bowel cancer screening	0.5	0.6	1.3	1.1	0.3	-1.1	0.1	0.3
Diabetes diagnosed by doctor	1.0	1.7	4.6	0.6	-1.2	2.1	-0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.3	0.1	-0.9	1.1	-0.1	0.5
Friendships satisfaction	1.4	1.7	3.0	-1.1	0.3	1.7	1.2	-1.7
Qualifications: nursing, teaching	0.2	0.3	1.4	-0.4	1.2	0.1	0.0	0.2
Commuting to job workplace: Walk	0.6	0.6	2.2	-0.8	-1.5	-0.1	0.5	0.3
Eye problems/disorders: Cataract	0.7	0.8	2.6	-0.2	1.6	-0.3	-0.3	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.0	1.7	4.8	1.2	2.2	0.3	1.1	-0.9
Medication for cholesterol	0.1	0.2	0.7	-0.8	0.3	0.6	0.1	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.4	6.4	0.5	1.9	-2.5	-1.0	-0.7
Back pain experienced in last month	0.6	0.8	3.1	0.8	-1.8	0.0	0.2	-0.6
Mineral and other dietary supplements	2.9	3.9	12.2	0.4	-1.8	-1.7	3.5	-1.1
Breast cancer (self-reported)	1.3	1.5	3.3	-0.9	0.6	-0.5	1.8	-1.7
Asthma (self-reported)	3.1	6.1	9.9	3.1	-3.0	-1.1	-2.6	1.9
Osteoporosis (self-reported)	0.5	0.6	1.2	-0.4	0.9	-0.6	-1.1	-0.4
Osteoarthritis (self-reported)	0.8	1.0	2.2	-0.7	1.5	1.3	0.0	0.6
Medication: Aspirin	0.9	1.1	2.2	1.3	-1.0	-0.3	-1.5	0.9
Medication: Gliclazide	1.0	1.2	2.9	-0.1	-1.7	1.4	1.0	-0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	1.7	-1.3	0.2	0.6	1.2	-0.2
Smoking status: Current	0.5	0.8	1.3	-0.8	0.8	-1.2	1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	8.6	-1.0	-1.0	-0.9	0.1	-2.9
Whole body water mass	0.5	3.1	9.5	-3.1	1.8	-0.8	0.4	-1.5
Leg predicted mass (right)	0.5	2.5	6.8	-2.6	1.3	-0.9	0.4	-1.7
Arm fat mass (left)	0.3	1.2	2.6	-0.2	1.2	-1.6	-1.0	-0.9
Number of self-reported non-cancer illnesses	1.0	1.7	3.0	1.6	-1.2	0.5	1.1	1.7
Average weekly champagne plus white wine intake	0.5	0.7	1.4	1.2	-0.5	-0.1	-0.7	1.1
Miserableness	0.6	1.1	2.2	-1.0	0.3	1.5	1.0	-1.0
Guilty feelings	1.4	2.1	3.3	-1.7	-1.2	1.3	1.8	-1.1
Wears glasses or contact lenses	1.5	1.7	4.3	0.0	2.0	-2.1	0.3	-0.1
Ever taken oral contraceptive pill	0.2	0.3	0.5	0.3	-0.5	-0.1	0.7	0.6
Hearing aid user	0.7	0.8	3.1	-0.5	-0.3	0.8	0.3	-1.8
Mother’s age at death	0.9	1.2	2.0	1.0	0.6	1.4	-1.3	0.8
Financial situation satisfaction	0.4	0.5	1.1	-0.7	-0.5	1.1	0.6	-0.1
Tinnitus: Yes, now most or all of the time	1.0	1.1	4.1	-1.0	2.0	-0.5	-0.6	0.1
Commuting to job workplace: Public transport	0.9	1.1	2.9	0.4	-1.7	0.1	0.4	1.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.4	0.8	-0.5	0.7	0.7
Medication: Blood pressure	0.3	0.5	1.3	1.2	0.5	-0.4	-0.8	0.2
Pain type(s) experienced in last month: Hip pain	0.8	0.9	3.0	1.2	0.3	1.7	0.4	0.2
Supplements: Fish oil (including cod liver oil)	1.7	2.2	5.4	-0.7	1.5	1.4	-2.3	0.8
High cholesterol (Self-reported)	0.3	0.5	1.8	-1.4	-0.3	0.6	0.3	-0.6
Medication: Bendroflumethiazide	0.7	1.0	2.9	0.7	0.9	-0.9	-1.7	0.1
Medication: Paracetamol	0.4	0.6	1.4	-0.4	-1.2	0.4	0.2	-1.1
Medication: Lisinopril	0.2	0.3	0.8	0.7	-0.4	0.9	0.2	0.4
Medication: Atorvastatin	0.5	0.6	1.3	0.8	-1.1	1.0	0.2	0.5
Illnesses of father: High blood pressure	0.3	0.4	1.0	1.0	-0.2	0.4	0.2	0.8
Alcohol drinker status: Never	0.3	0.4	0.8	-0.5	0.5	-0.9	0.0	-0.9
Ever smoked	0.7	1.3	3.3	-1.8	0.3	-0.3	1.4	-1.0
Basal metabolic rate	0.4	2.3	6.0	-2.5	1.7	-1.0	0.0	-1.3
Leg fat percentage (left)	0.4	1.4	2.8	1.6	0.9	-1.0	-1.7	0.0
Arm fat-free mass (left)	0.4	2.2	6.0	-2.4	1.5	-0.9	0.2	-1.5
Number of operations (self-reported)	0.3	0.4	1.4	-0.3	1.2	-0.5	0.1	-0.5
Average weekly beer plus cider intake	0.9	1.2	2.3	0.6	-1.5	1.4	1.3	0.2
Irritability	0.4	0.7	1.7	-0.5	0.1	1.3	-0.3	1.2
Risk taking	0.9	1.4	3.9	-0.3	2.0	1.6	0.2	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.6	0.0	-0.0	0.2	0.8	-0.1
Fractured/broken bones in last 5 years	2.4	3.1	8.4	-2.2	2.9	0.7	0.5	-1.2
Age started oral contraceptive pill	1.6	2.1	6.3	-0.4	2.5	-0.5	0.8	-1.7
Diastolic blood pressure, automated reading	0.2	0.7	2.0	1.0	-0.2	-1.4	-0.4	0.7
Ever depressed for a whole week	0.1	0.1	0.3	-0.5	-0.2	0.2	0.6	-0.3
Unable to work because of sickness or disability	2.4	3.2	6.4	-0.5	-1.8	-1.9	1.5	-2.5
Commuting to job workplace: Cycle	1.5	1.8	8.9	0.1	-0.2	-3.0	0.3	0.0
Myopia	0.4	0.5	2.1	-1.4	-0.5	-0.4	0.0	-0.5
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.8	-1.2	0.0	-0.9	-0.2	-1.7
Cholesterol lowering medication	0.7	1.0	2.8	0.2	-0.8	-0.8	-1.7	0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.1	1.5	0.9	1.0	0.2	0.4
Pain experienced in last month	0.6	1.1	1.8	-1.3	-0.7	-1.2	1.3	-0.3
Supplements: Calcium	0.5	0.6	1.2	-0.6	0.7	-1.1	0.7	-0.5
Basal cell carcinoma (self-reported)	0.8	0.9	1.7	-1.1	0.9	-0.1	0.9	-1.3
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.7	0.5	-1.6	0.1	1.4	1.2
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.9	0.3	-2.0	2.4	1.0	0.5
Heart disease (siblings)	0.7	0.9	2.2	1.0	-0.9	-1.5	-0.1	0.5
Alcohol drinker status: Previous	0.6	0.7	1.8	-0.5	-1.0	0.5	0.6	-1.3
Pack years of smoking	0.6	0.8	1.2	1.1	1.0	0.9	-0.3	1.0
Impedance of whole body	0.7	3.3	9.4	3.1	-0.7	1.3	0.2	2.3
Leg fat mass (left)	0.3	1.0	2.1	0.4	1.4	-0.8	-1.4	-0.3
Arm predicted mass (left)	0.5	2.7	7.1	-2.7	1.8	-1.0	0.2	-1.4