Hub : Genes

MRPL30

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0388 0.0130 1.1e-12 0.046 0.043 0.043 0.044 0.044 1.2e-14 9.6e-14 9.2e-14 3.8e-14 3.8e-14
2 TCGA Bladder Urothelial Carcinoma 0.1050 0.0610 1.2e-03 0.034 0.050 0.046 NA 0.040 6.5e-04 4.1e-05 8.8e-05 NA 2.4e-04
3 TCGA Brain Lower Grade Glioma 0.0418 0.0217 3.2e-05 0.042 0.039 0.032 NA 0.031 1.5e-05 2.7e-05 1.2e-04 NA 1.5e-04
4 TCGA Lung Adenocarcinoma 0.0601 0.0440 1.3e-05 0.051 0.050 0.044 NA 0.046 1.2e-06 1.6e-06 6.7e-06 NA 3.7e-06
5 TCGA Prostate Adenocarcinoma 0.0836 0.0358 5.1e-08 0.053 0.072 0.069 NA 0.062 2.9e-06 5.2e-08 1.1e-07 NA 4.6e-07

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 4.6 7.3 18.7 2.0 -4.3 0.1 -2.4 -2.9
Bipolar Disorder or Schizophrenia 0.9 2.2 7.8 0.3 -2.8 0.8 -0.8 -1.3
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 -0.4 -0.1 0.2 -0.6 0.6
Depression (Nagel 2018) 0.1 0.2 0.3 -0.1 0.3 0.3 -0.6 0.6
Intelligence (Savage-Jansen 2018) 0.6 1.7 3.4 -0.8 1.8 0.3 1.8 1.1
Neuroticism (Nagel 2018) 0.2 0.6 1.5 -0.6 0.9 0.2 -0.1 1.2
Schizophrenia (2018) 0.3 0.7 1.6 -1.3 -0.1 0.9 0.9 0.6
Schizophrenia vs Biploar Disorder 5.0 6.6 15.0 -2.4 3.9 0.4 1.9 3.0
Worry (Nagel 2018) 0.5 1.1 3.1 -0.6 1.8 -0.8 -0.0 1.2
Alzheimer’s Disease (in mother) 2.2 2.6 3.1 1.7 -1.0 -1.7 -1.7 -1.8
Alzheimer’s Disease (in father) 1.8 2.0 3.5 -1.9 -0.6 1.8 1.1 1.1
Alzheimer’s Disease (including proxy) 0.2 0.3 0.8 0.2 -0.9 -0.1 -0.7 -0.5
Crohns Disease (2017) 0.1 0.3 0.5 0.4 -0.7 -0.4 -0.1 -0.7
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.3 -0.3 -0.2 -0.0 -0.1
Ulcerative Colitis (UC) 0.2 0.5 1.3 -1.1 0.4 0.3 0.4 0.8
Major Depression (MDD) 0.4 0.5 1.7 0.8 0.4 -0.1 -1.3 0.1
Reaction Time 0.2 0.3 0.9 0.4 0.0 -0.9 0.1 -0.7
Verbal and Numeric Reasoning (VNR) 2.2 5.3 7.6 -1.9 2.8 1.5 2.6 2.5
Breast Cancer 0.6 1.5 3.8 0.9 0.1 -1.6 -1.9 -0.6
Ovarian Cancer 0.6 0.8 1.7 -1.1 0.3 0.9 1.3 0.7
Prostate Cancer 0.4 0.6 1.1 -0.8 -0.5 0.9 1.1 0.0
Age at First Birth 0.4 0.5 0.8 -0.9 0.6 0.6 0.7 0.8
Bipolar Disorder (2011) 2.2 2.1 5.5 1.3 -2.4 0.6 -1.4 -1.2
Body Mass Index (BMI) (2010) 0.1 0.2 0.5 -0.0 0.7 -0.5 -0.0 0.3
Coronary Artery Disease (CAD) 0.4 0.5 1.0 0.7 -0.5 -0.3 -1.0 -0.7
Crohns Disease (2012) 0.2 0.4 0.9 0.5 -0.7 -0.3 -0.1 -1.0
Mean Putamen Volume 1.0 1.1 1.9 -1.1 0.7 1.1 1.4 0.9
Fasting Glucose 0.1 0.1 0.2 0.1 0.4 -0.4 -0.2 0.1
HbA1C 0.2 0.3 0.8 -0.5 0.9 0.0 0.1 0.5
HDL Cholesterol 0.2 0.3 1.0 0.3 -1.0 0.1 -0.5 -0.5
LDL Cholesterol 0.1 0.2 0.5 0.4 0.1 -0.6 -0.7 -0.2
Lupus 0.0 0.1 0.2 0.1 -0.4 0.3 -0.1 0.0
Neuroticism (2016) 0.1 0.1 0.3 -0.0 0.5 -0.5 -0.3 0.2
Primary Biliary Cirrhosis 0.3 0.4 1.0 -0.4 1.0 -0.4 0.3 0.8
Rheumatoid Arthritis 0.5 0.7 2.0 0.4 -1.4 -0.1 -1.0 -0.8
Schizophrenia (2014) 0.1 0.2 0.4 -0.6 -0.1 0.5 0.1 0.4
Triglycerides 0.1 0.1 0.3 -0.2 0.5 -0.2 0.3 0.2
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.1 0.6 0.7 -1.0 -0.7 0.2
Ulcerative Colitis 0.4 0.6 2.1 -0.1 1.5 -0.3 0.1 0.8
Blood Eosinophil Count 0.3 2.4 7.8 -0.8 2.8 -0.2 1.1 1.5
Blood Platelet Count 0.0 0.1 0.1 0.1 0.3 -0.2 0.4 -0.0
Blood Red Count 0.6 5.5 9.1 2.2 -2.2 -1.9 -3.0 -2.3
Blood White Count 0.3 2.5 3.8 1.4 -2.0 -0.3 -1.8 -1.8
Heel T-Score 1.1 8.5 13.8 3.1 -3.7 -1.4 -2.2 -3.5
BMI 0.4 2.1 7.6 1.4 0.3 -1.0 -2.8 -0.1
Height 0.5 10.0 16.6 -2.8 4.1 1.3 3.5 3.4
Waist Hip Ratio (WHR) 1.0 4.5 7.1 -2.4 2.4 0.8 2.7 1.8
Systolic Blood Pressure 0.2 0.9 1.5 -0.9 0.7 1.2 0.9 1.0
Smoking Status 2.9 7.0 17.2 2.0 -4.1 -0.3 -1.8 -3.3
Allergy or Eczema 0.5 1.2 4.6 -0.1 2.1 -0.5 0.5 1.1
Cardiovascular Disease 0.1 0.3 0.7 0.1 -0.8 -0.0 -0.8 -0.1
Hypothyroidism (self reported) 0.6 1.5 3.2 1.6 -0.8 -0.3 -1.8 -0.8
Respiratory disease 1.6 3.5 8.9 -1.2 3.0 0.5 0.9 2.4
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.3 -0.3 1.1 -0.4 0.2 0.2
Lung FEV1/FVC ratio 6.5 32.8 50.8 5.5 -7.1 -3.1 -5.5 -6.5
Lung FVC 0.3 1.5 3.2 -0.9 0.7 1.8 0.9 1.5
Neuroticism 0.1 0.3 0.8 -0.4 0.5 -0.2 -0.5 0.9
Chronotype (morning person) 0.0 0.1 0.1 0.0 -0.4 0.2 0.3 -0.3
Hair Pigment 0.1 1.7 3.0 1.3 -1.6 -0.1 -1.7 -1.1
Tanning 0.0 0.6 1.0 -0.9 -0.0 1.0 0.9 0.5
Hand grip strength (left) 2.1 5.6 9.7 -1.9 3.1 0.9 2.5 2.8
Number of treatments/medications taken 0.2 0.4 0.6 0.6 -0.7 0.2 -0.8 -0.7
Average weekly spirits intake 0.3 0.3 0.7 0.4 -0.6 -0.4 -0.9 -0.4
Sensitivity / hurt feelings 0.3 0.5 1.7 -0.1 1.3 -0.6 -0.3 0.6
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.4 -1.2 0.2 0.9 0.4 1.1
Hearing difficulty/problems: Yes 0.5 0.8 1.9 -0.4 1.4 -0.5 1.1 0.6
Relative age of first facial hair 0.0 0.1 0.2 -0.2 0.2 0.3 0.3 0.5
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 2.2 1.5 -1.2 -0.8 -1.4 -1.2
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.5 -0.3 0.7 -0.4 0.0 0.5
Ever had hysterectomy (womb removed) 4.9 5.6 8.4 2.6 -1.8 -2.1 -2.9 -2.3
Systolic blood pressure, automated reading 0.3 0.8 1.4 0.8 1.2 -0.9 -1.2 0.2
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.1 0.2 -0.3 0.4 0.1 -0.3
Angina 0.1 0.1 0.4 0.6 0.2 0.1 -0.5 -0.1
Medication for hormone replacement therapy 1.6 1.8 3.8 1.4 -0.1 -1.9 -1.2 -1.3
Vitamin and mineral supplements 0.6 0.8 2.0 -0.8 -0.6 1.4 0.7 0.6
Supplements: Zinc 0.1 0.1 0.4 0.1 0.3 -0.6 0.2 -0.4
Medication: Co-codamol 0.5 0.6 0.9 0.7 -0.6 -0.7 -0.8 -1.0
Medication: Metformin 1.0 1.4 3.0 -1.1 1.7 0.7 0.9 1.2
Diabetes (father) 1.7 2.1 5.5 -0.6 2.3 0.8 0.9 1.8
Diabetes (mother) 1.2 1.5 2.8 0.7 -1.4 -1.3 -0.7 -1.7
Severe depression (siblings) 1.4 1.5 2.3 -1.5 0.3 1.5 0.8 1.5
Pack years adult smoking proportion 0.2 0.2 0.9 0.1 1.0 0.1 -0.3 0.5
Impedance of leg (right) 0.4 1.9 4.6 -1.3 -0.0 1.7 2.1 0.5
Leg fat-free mass (left) 0.2 0.9 1.6 0.2 1.3 -1.0 -1.0 0.8
Trunk fat percentage 0.1 0.5 1.6 0.5 0.4 -0.3 -1.3 0.3
Hand grip strength (right) 3.1 8.4 14.1 -2.3 3.8 1.3 3.1 3.3
Townsend deprivation index at recruitment 1.5 2.1 3.4 -1.5 0.9 1.8 1.4 1.4
Current tobacco smoking 5.0 8.2 17.4 2.2 -4.2 -0.8 -2.4 -3.5
Average weekly fortified wine intake 2.2 2.6 4.8 1.7 -0.4 -2.2 -1.3 -1.9
Maternal smoking around birth 1.5 2.1 7.0 0.6 -2.7 0.4 -1.0 -1.5
Fed-up feelings 0.2 0.4 0.8 -0.4 -0.9 0.5 -0.7 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.7 0.0 1.3 -0.6 -0.6 0.7
Relative age voice broke 0.2 0.3 0.7 -0.3 0.4 0.8 0.5 0.6
Taking other prescription medications 0.6 1.0 2.4 -1.0 0.0 1.5 1.0 0.5
Age when periods started (menarche) 1.6 4.0 7.4 -1.9 0.4 2.7 2.4 1.7
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 3.3 1.8 -0.3 -1.2 -1.8 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 2.0 4.6 6.8 2.5 -1.8 -1.7 -2.6 -2.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.5 0.6 -0.2 0.0 -0.7 -0.0
Qualifications: CSEs or equivalent 1.4 1.9 3.3 -1.1 1.1 1.8 0.5 1.8
Serious illness, injury or assault to yourself 0.4 0.4 0.7 0.7 -0.8 0.2 -0.8 -0.6
High blood pressure 0.1 0.1 0.3 -0.5 -0.3 0.4 -0.1 0.4
Hayfever, allergic rhinitis or eczema 0.8 1.8 5.9 -0.4 2.4 0.1 0.6 1.6
Multivitamins +/- minerals 0.6 0.7 1.7 0.8 -0.0 -1.3 -0.7 -0.9
Stomach or abdominal pain in last month 2.0 2.5 4.1 2.0 -0.7 -1.6 -1.8 -1.5
Supplements: Glucosamine 0.8 1.1 1.9 1.0 -0.9 -0.8 -1.4 -0.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.9 1.3 0.1 -0.8 -1.4 -0.4
Medication: Atenolol 0.6 0.8 1.4 0.7 -1.1 -0.6 -0.7 -1.2
Medication: Levothyroxine sodium 0.4 0.7 1.8 0.7 -1.0 0.3 -1.3 -0.3
Sitting height 0.9 6.6 9.4 -2.4 3.0 1.2 2.7 3.1
Chronic bronchitis/emphysema (father) 4.2 5.0 6.1 2.3 -1.5 -2.5 -2.3 -2.4
High blood pressure (mother) 0.2 0.3 0.5 -0.6 0.1 0.7 0.6 0.6
Body mass index (BMI) 0.5 2.1 7.6 1.3 -0.5 -0.9 -2.8 -0.4
Impedance of leg (left) 0.6 2.9 6.7 -1.6 0.3 2.1 2.6 0.8
Leg predicted mass (left) 0.2 0.8 1.5 0.2 1.2 -1.0 -1.0 0.8
Trunk fat mass 0.1 0.6 1.6 0.4 0.8 -0.4 -1.3 0.5
Waist circumference 0.2 0.7 1.9 -0.2 1.4 -0.5 -0.8 0.9
Number of incorrect matches in round 0.6 1.1 4.1 0.2 -2.0 -0.1 -0.5 -0.9
Past tobacco smoking 0.6 1.1 3.1 -0.8 1.8 -0.6 0.5 1.0
Alcohol usually taken with meals 0.1 0.2 0.6 0.6 0.5 -0.8 0.1 0.0
Nervous feelings 0.2 0.4 0.7 -0.8 0.5 0.5 0.5 0.8
Frequency of tenseness / restlessness in last 2 weeks 3.0 4.7 7.1 -2.7 0.9 2.5 1.6 2.6
Hearing difficulty/problems with background noise 0.8 1.3 4.0 -0.5 2.0 -0.1 0.5 1.3
Hair/balding pattern: Pattern 2 0.1 0.2 0.5 0.1 0.7 0.3 -0.0 0.4
Had menopause 1.0 1.3 3.8 0.4 1.5 -1.9 0.0 -0.1
Had other major operations 2.2 2.7 4.3 2.1 -0.4 -1.9 -2.0 -1.2
Forced vital capacity (FVC) 2.7 10.6 13.8 -2.9 3.4 2.9 3.3 3.7
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.4 6.3 2.3 -2.2 -1.2 -2.5 -2.0
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 1.7 0.6 -1.2 -1.0 -0.8 -1.3
Qualifications: None of the above 2.6 5.5 11.2 1.5 -3.3 -0.9 -2.5 -2.6
Financial difficulties in last 2 years 0.4 0.6 1.9 0.3 1.4 -0.9 -0.1 0.1
Mouth/teeth dental problems 0.9 1.4 2.7 -1.2 0.9 1.2 0.9 1.6
Heart attack 0.4 0.5 0.7 0.9 -0.0 -0.8 -0.6 -0.9
Allergy 0.8 1.8 5.6 0.4 -2.4 -0.1 -0.3 -1.7
Pain all over the body in last month 4.7 5.0 9.4 -1.9 3.1 1.1 2.3 2.4
Diabetes (self-reported) 0.1 0.2 0.7 -0.2 0.9 -0.3 0.2 -0.1
Hayfever/allergic rhinitis (self-reported) 2.9 3.8 4.9 -2.0 1.7 1.8 2.0 2.2
Medication: Ramipril 0.0 0.0 0.1 -0.4 -0.1 -0.1 0.2 -0.2
Medication: Simvastatin 1.2 1.7 3.9 0.9 -2.0 -0.5 -1.1 -1.6
Fluid intelligence score 2.5 5.3 9.1 -1.8 2.7 1.4 3.0 2.2
Illnesses of siblings 0.4 0.5 2.2 0.4 1.5 -0.3 0.3 0.3
Neuroticism score 0.1 0.2 0.9 -0.0 -0.1 -0.4 -1.0 0.2
Weight 0.2 1.0 1.8 0.2 1.3 -0.7 -1.2 1.0
Impedance of arm (right) 0.1 0.6 2.7 -0.2 0.5 -0.0 1.6 -0.2
Arm fat percentage (right) 0.6 2.5 7.2 1.7 -0.6 -1.2 -2.7 -0.8
Trunk fat-free mass 0.1 0.6 1.0 0.4 0.9 -0.8 -1.0 0.7
Hip circumference 0.2 0.7 1.8 0.3 0.9 -0.4 -1.3 0.8
Time employed in main current job 0.7 0.8 1.1 -0.9 0.9 0.6 1.0 1.0
Alcohol intake versus 10 years previously 1.0 1.5 2.1 1.4 -1.1 -0.9 -1.4 -1.4
Father’s age at death 1.2 1.7 2.7 -1.2 0.7 1.6 1.6 1.1
Worrier / anxious feelings 0.6 1.2 3.0 -0.0 1.7 -1.6 -0.2 0.5
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.5 -0.3 -0.0 0.2 -0.7 0.7
Falls in the last year 0.1 0.2 0.3 -0.6 -0.3 0.4 0.3 0.2
Hair/balding pattern: Pattern 3 0.4 0.5 1.8 0.5 0.7 -1.3 -0.3 -0.2
Number of live births 0.3 0.4 1.2 0.0 1.1 0.3 0.1 0.7
Forced expiratory volume in 1-second (FEV1) 1.2 4.0 5.3 -1.5 2.0 2.1 2.0 2.3
Pulse rate 0.9 1.5 3.9 -1.0 2.0 -0.1 0.9 1.4
Happiness 1.2 1.5 1.8 -1.4 1.3 0.7 1.3 1.3
Noisy workplace 1.7 2.1 3.0 1.1 -1.6 -1.1 -1.5 -1.7
Qualifications: A levels/AS levels or equivalent 1.3 2.9 7.7 -0.7 2.8 -0.6 2.0 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.3 2.7 0.9 -1.6 -0.5 -0.9 -1.3
Mouth/teeth dental problems: Dentures 1.1 1.9 2.5 1.2 -1.6 -0.7 -1.6 -1.6
Asthma 0.6 1.1 3.0 -0.7 1.7 0.2 0.5 1.3
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 2.6 1.4 -1.6 -0.8 -1.6 -1.4
Medication: Cholesterol lowering 0.3 0.4 1.2 0.2 -1.1 0.5 -0.6 -0.5
Depression (self-reported) 1.6 2.0 4.0 -1.6 0.2 2.0 1.1 1.4
Medication: Lansoprazole 5.5 6.3 8.4 2.9 -1.2 -2.9 -2.9 -2.3
Prospective memory result 1.8 2.2 4.6 1.5 -1.0 -1.4 -2.2 -1.2
Lung cancer (father) 1.4 1.6 2.2 1.5 -0.7 -1.2 -1.5 -1.3
Illnesses of mother 0.4 0.5 0.8 -0.7 0.2 0.8 0.9 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.8 -1.1 0.6 1.9 1.4 1.4
Pulse wave Arterial Stiffness index 0.6 0.7 1.7 -0.6 1.3 0.3 0.3 1.2
Impedance of arm (left) 0.3 1.4 4.7 -0.9 1.1 0.3 2.2 0.5
Arm fat mass (right) 0.4 1.5 5.2 1.2 0.3 -1.0 -2.3 -0.0
Trunk predicted mass 0.1 0.6 1.1 0.4 0.9 -0.8 -1.0 0.7
Standing height 0.7 6.6 13.0 -2.1 3.6 0.3 2.8 2.8
Length of working week for main job 1.2 1.3 3.4 -0.9 1.8 -0.0 1.0 1.1
Exposure to tobacco smoke at home 2.5 2.8 4.8 1.9 0.3 -2.2 -2.0 -1.2
Breastfed as a baby 0.4 0.4 1.4 0.1 1.2 -0.5 0.1 0.7
Tense / ‘highly strung’ 1.0 1.6 2.4 -1.6 0.5 1.3 1.1 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 2.3 -0.2 -1.5 0.4 -0.7 -0.6
Hair/balding pattern: Pattern 4 0.7 1.8 2.9 1.3 -1.7 -0.6 -1.5 -1.4
Birth weight of first child 0.0 0.0 0.0 -0.0 0.0 0.2 0.2 -0.1
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.0 0.7 0.4 0.7 0.6
Pulse wave reflection index 0.4 0.5 1.5 -0.4 1.2 0.3 0.4 0.8
Ever highly irritable/argumentative for 2 days 1.6 2.0 2.9 -1.7 0.7 1.6 1.0 1.6
Loud music exposure frequency 1.5 1.6 4.2 -1.4 -0.0 2.0 0.7 1.2
Qualifications: O levels/GCSEs or equivalent 3.8 6.1 17.9 -1.2 4.2 -0.3 2.4 2.3
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 3.3 -0.6 1.8 -0.2 1.0 0.8
Blood clot in the leg (DVT) 1.8 2.3 4.0 1.7 -0.4 -1.7 -2.0 -1.2
Medication: Paracetamol 0.2 0.3 0.6 0.3 0.8 -0.5 -0.6 0.2
Headache pain in last month 3.2 5.6 9.3 2.5 -1.8 -1.8 -3.0 -2.4
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.6 -0.6 1.6 0.2 1.0 1.0
Glaucoma (self-reported) 0.1 0.1 0.5 0.7 0.1 0.0 -0.0 -0.3
Gout (self-reported) 1.2 1.6 2.6 -1.5 1.3 0.6 1.1 1.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 3.8 1.5 -1.1 -0.7 -1.9 -1.2
Medication: Amlodipine 1.3 1.8 2.5 -1.3 1.0 1.6 1.3 1.5
Medication: Ventolin 100micrograms inhaler 1.5 2.0 3.2 -1.8 0.8 1.5 1.4 1.4
Birth weight 0.6 1.4 2.4 1.5 -0.2 -1.6 -1.0 -1.2
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.4 -0.7 0.2 1.2 0.3 0.9
High blood pressure (siblings) 0.4 0.6 1.8 0.1 -1.4 -0.1 -0.9 -0.7
Forced vital capacity (FVC), Best measure 1.7 6.1 7.5 -2.2 2.1 2.6 2.6 2.7
Body fat percentage 0.3 1.0 3.7 1.0 -0.0 -0.6 -1.9 -0.2
Leg fat percentage (right) 0.6 2.3 7.6 1.5 -0.6 -0.8 -2.8 -0.7
Arm fat-free mass (right) 0.1 0.7 1.2 0.1 1.1 -0.5 -1.0 1.0
Exposure to tobacco smoke outside home 0.9 1.2 3.6 0.7 1.9 -1.1 -0.7 0.3
Comparative body size at age 10 0.0 0.1 0.4 -0.0 0.2 -0.2 -0.6 0.3
Number of full brothers 1.7 2.1 3.1 1.2 -1.8 -0.9 -1.4 -1.8
Worry too long after embarrassment 0.2 0.4 0.9 -0.8 0.2 0.7 0.1 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.9 0.8 -1.7 0.1 -0.9 -1.1
Wheeze or whistling in the chest in last year 0.4 0.7 1.4 -0.8 1.1 0.6 0.2 1.2
Number of children fathered 0.6 0.7 1.3 1.1 -0.3 -0.5 -1.1 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.7 2.0 3.0 -1.5 1.7 0.8 1.1 1.7
Age at first live birth 0.1 0.1 0.4 -0.2 0.1 -0.3 0.7 0.0
Pulse wave peak to peak time 0.5 0.5 1.1 0.5 -1.0 -0.4 -0.2 -1.0
Health satisfaction 0.5 0.7 1.5 -0.6 1.1 0.4 -0.4 1.2
Shortness of breath walking on level ground 0.3 0.4 0.9 0.2 -0.9 -0.6 -0.6 -0.5
Qualifications: College or University degree 1.7 5.4 11.3 -1.6 3.4 0.3 2.8 2.2
Eye problems/disorders: None of the above 0.5 0.6 1.3 -0.6 1.0 0.2 0.1 1.1
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.6 1.1 -1.1 -1.1 -0.9 -1.6
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.2 -0.3 0.2 -0.3 0.4
Medication for pain relief, constipation, heartburn 0.5 0.8 2.4 -1.0 0.5 0.6 1.6 0.4
Neck or shoulder pain in last month 0.4 0.5 1.5 0.0 -1.2 0.8 -0.6 -0.5
Medication: Blood pressure 0.1 0.1 0.4 -0.5 -0.3 0.6 0.1 0.2
Angina (self-reported) 0.2 0.3 0.8 0.9 -0.1 -0.1 -0.7 -0.5
Migraine (self-reported) 0.0 0.1 0.1 0.3 -0.1 0.3 0.1 -0.2
Medication: Ibuprofen 0.8 1.0 1.7 0.9 -1.3 -0.3 -1.1 -1.0
Medication: Allopurinol 0.3 0.4 0.6 -0.7 0.8 -0.1 0.3 0.8
Medication: Omeprazole 0.1 0.1 0.1 -0.3 -0.4 0.2 -0.4 0.2
Medication: Seretide 50 evohaler 5.5 6.3 9.8 -2.2 3.1 1.4 2.5 2.9
Mean time to correctly identify matches 0.1 0.3 1.0 0.1 0.6 -1.0 0.1 -0.2
Heart disease (mother) 1.1 1.4 2.6 1.6 -0.3 -1.1 -1.5 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 0.6 -0.6 -0.5 0.8 0.6 0.4
Whole body fat mass 0.2 0.7 2.8 0.6 0.4 -0.6 -1.7 0.3
Leg fat mass (right) 0.5 1.8 6.4 1.3 0.0 -0.9 -2.5 -0.3
Arm predicted mass (right) 0.1 0.7 1.3 0.0 1.1 -0.4 -0.9 1.1
Pulse rate, automated reading 0.1 0.2 0.5 0.0 0.6 -0.7 -0.3 0.2
Alcohol intake frequency. 2.0 4.7 6.8 2.4 -1.5 -1.8 -2.6 -2.4
Comparative height size at age 10 0.3 1.7 5.2 -0.7 2.3 -0.9 0.7 1.3
Number of full sisters 0.7 0.8 2.3 0.6 0.8 -1.5 -0.6 -0.6
Suffer from ‘nerves’ 0.2 0.3 1.1 0.2 0.5 -1.0 -0.6 -0.1
Overall health rating 0.8 1.6 4.5 -0.7 2.1 -0.5 -0.5 1.6
Chest pain or discomfort 3.8 5.5 9.9 2.8 -1.1 -2.0 -3.1 -2.1
Had major operations 0.6 0.7 1.0 -0.8 0.4 0.9 0.8 1.0
Age at last live birth 0.1 0.1 0.4 -0.0 0.6 -0.5 0.3 0.1
Family relationship satisfaction 1.0 1.3 2.2 -1.3 1.3 0.4 1.5 0.7
Leg pain on walking 0.5 0.7 1.1 -0.6 1.0 0.7 0.7 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.7 1.6 -0.4 -1.3 1.2 0.0 0.1
Commuting to job workplace: Car/motor vehicle 5.1 5.9 7.8 2.5 -1.6 -2.8 -2.8 -2.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.7 -0.1 1.3 -0.1 0.2 0.8
Medication: Aspirin 0.2 0.2 0.6 -0.3 0.5 0.4 0.2 0.8
Supplements: Vitamin C 0.1 0.1 0.2 0.2 -0.3 0.5 -0.3 -0.3
Knee pain experienced in last month 5.2 8.0 11.0 2.9 -3.1 -1.8 -3.3 -2.8
Hypertension (Self-reported) 0.1 0.2 0.4 -0.6 0.0 0.5 0.0 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 4.3 1.8 -0.9 -1.8 -2.1 -1.1
Illnesses of father: Heart disease 0.6 0.9 1.5 1.2 0.5 -1.2 -1.1 -0.4
Illnesses of siblings: Diabetes 3.4 4.2 6.7 1.7 -2.6 -1.3 -1.8 -2.6
Smoking status: Previous 0.3 0.4 1.0 0.5 -1.0 0.8 -0.1 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 2.0 2.8 -1.4 1.4 1.0 1.4 1.7
Whole body fat-free mass 0.1 0.8 1.3 0.3 1.2 -0.9 -1.1 0.8
Leg fat-free mass (right) 0.2 0.9 2.4 0.0 1.6 -0.9 -0.7 1.0
Arm fat percentage (left) 0.5 2.0 6.2 1.5 -0.3 -1.1 -2.5 -0.6
Average weekly red wine intake 1.4 2.0 2.9 -1.4 1.7 0.7 1.6 1.5
Handedness (chirality/laterality): Left-handed 3.8 4.6 6.0 -2.4 2.3 1.4 2.2 2.3
Mood swings 0.1 0.3 1.0 -0.1 -0.2 -0.2 -1.0 0.5
Loneliness, isolation 0.0 0.0 0.1 -0.4 -0.1 -0.1 -0.2 0.1
Long-standing illness, disability or infirmity 0.2 0.3 0.6 -0.4 0.8 0.1 -0.1 0.7
Ever had bowel cancer screening 1.9 2.2 3.5 1.9 -0.6 -1.8 -1.5 -1.3
Diabetes diagnosed by doctor 0.1 0.2 0.8 0.0 0.9 -0.1 0.0 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 1.3 -0.6 0.8 1.0 1.1 1.0
Friendships satisfaction 0.3 0.3 0.8 -0.4 0.9 0.1 0.7 0.4
Qualifications: nursing, teaching 0.2 0.3 0.6 0.5 0.6 -0.7 -0.2 -0.1
Commuting to job workplace: Walk 0.6 0.6 1.4 -0.3 1.2 0.4 0.9 0.7
Eye problems/disorders: Cataract 1.2 1.4 4.9 0.4 -2.2 0.5 -0.7 -1.2
Mouth/teeth dental problems: Mouth ulcers 1.8 2.8 5.4 1.3 -2.2 -1.1 -0.9 -2.3
Medication for cholesterol 0.5 0.8 1.6 -0.9 -0.8 1.2 0.9 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.0 0.1 0.1 -0.1 -0.3 0.2 -0.3 0.2
Back pain experienced in last month 0.6 0.9 2.4 0.5 -1.0 -0.8 -1.6 -0.5
Mineral and other dietary supplements 1.2 1.6 2.4 -1.3 0.6 1.4 1.6 1.2
Breast cancer (self-reported) 0.9 1.1 3.9 -0.0 2.0 -0.4 0.2 1.2
Asthma (self-reported) 0.7 1.3 2.9 -0.9 1.7 0.5 0.7 1.5
Osteoporosis (self-reported) 0.8 1.0 2.3 0.7 -1.2 -1.0 -0.4 -1.5
Osteoarthritis (self-reported) 0.2 0.3 1.0 0.6 -0.1 0.0 -1.0 -0.2
Medication: Aspirin 0.3 0.3 0.6 -0.5 0.5 0.7 0.5 0.8
Medication: Gliclazide 0.4 0.5 1.7 -0.3 1.3 -0.1 0.2 0.7
Illnesses of father: None of the above (group 1) 1.1 1.3 2.5 -1.1 0.2 1.5 1.6 0.9
Smoking status: Current 5.9 9.3 19.5 2.4 -4.4 -0.9 -2.5 -3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.2 1.1 -0.6 0.1 -1.0 -0.3
Whole body water mass 0.1 0.7 1.3 0.4 1.0 -0.9 -1.1 0.7
Leg predicted mass (right) 0.2 0.9 2.2 0.0 1.5 -0.9 -0.7 1.0
Arm fat mass (left) 0.4 1.6 5.2 1.2 0.2 -1.1 -2.3 -0.1
Number of self-reported non-cancer illnesses 0.1 0.3 0.6 -0.4 -0.7 0.8 -0.3 0.1
Average weekly champagne plus white wine intake 1.0 1.3 3.9 -1.4 0.3 0.5 2.0 0.7
Miserableness 0.2 0.3 1.2 0.3 -0.1 0.1 -1.1 0.4
Guilty feelings 2.4 3.5 6.0 2.2 -1.5 -1.4 -2.5 -1.6
Wears glasses or contact lenses 0.2 0.3 0.9 -0.4 -1.0 0.2 0.2 -0.5
Ever taken oral contraceptive pill 1.2 1.3 4.4 -0.7 -0.9 2.1 0.8 0.7
Hearing aid user 0.7 0.8 2.9 -0.3 1.7 -0.0 0.4 1.0
Mother’s age at death 0.2 0.3 1.0 0.5 0.2 -1.0 0.0 -0.4
Financial situation satisfaction 0.1 0.1 0.4 0.0 0.6 0.2 0.0 0.2
Tinnitus: Yes, now most or all of the time 0.5 0.5 1.7 -0.0 -1.3 0.4 0.4 -0.8
Commuting to job workplace: Public transport 3.9 4.6 9.8 -2.4 1.0 1.9 3.1 1.8
Eye problems/disorders: Glaucoma 1.0 1.2 2.3 1.5 -0.0 -1.2 -1.0 -1.1
Medication: Blood pressure 0.0 0.1 0.3 -0.2 0.3 -0.0 -0.1 0.6
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.6 0.5 -1.3 0.4 -1.2 -0.6
Supplements: Fish oil (including cod liver oil) 0.7 0.9 1.3 1.0 -0.8 -0.7 -1.1 -1.1
High cholesterol (Self-reported) 1.0 1.9 4.0 1.0 -2.0 -0.6 -1.2 -1.5
Medication: Bendroflumethiazide 0.7 1.1 1.8 -1.1 0.9 1.1 0.7 1.3
Medication: Paracetamol 0.4 0.6 0.8 0.8 0.9 -0.9 -0.8 -0.0
Medication: Lisinopril 0.1 0.1 0.4 0.0 0.7 -0.2 0.4 0.0
Medication: Atorvastatin 0.3 0.4 0.9 0.4 -0.9 0.2 -1.0 -0.3
Illnesses of father: High blood pressure 0.5 0.6 2.2 -0.0 -1.5 0.3 -0.3 -0.8
Alcohol drinker status: Never 1.2 1.5 2.3 1.4 -0.2 -1.5 -1.3 -1.1
Ever smoked 0.8 1.4 2.8 1.1 -1.6 -0.4 -0.7 -1.7
Basal metabolic rate 0.2 0.9 1.6 0.2 1.3 -0.8 -1.1 0.9
Leg fat percentage (left) 0.4 1.5 5.6 1.2 -0.4 -0.5 -2.4 -0.5
Arm fat-free mass (left) 0.1 0.6 1.1 0.2 0.9 -0.5 -1.0 0.9
Number of operations (self-reported) 0.1 0.1 0.3 0.1 0.6 0.0 -0.1 0.2
Average weekly beer plus cider intake 0.5 0.7 1.5 -0.7 1.2 -0.2 0.9 0.9
Irritability 0.6 1.0 2.1 -1.5 0.2 1.2 0.9 0.9
Risk taking 0.3 0.4 1.2 -0.2 -1.1 0.7 0.4 -0.6
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 -0.3 0.5 0.3 0.4 0.2
Fractured/broken bones in last 5 years 0.2 0.2 0.4 0.3 -0.4 -0.3 -0.7 -0.5
Age started oral contraceptive pill 3.4 4.3 11.4 -1.3 3.4 0.6 1.6 2.4
Diastolic blood pressure, automated reading 0.2 0.8 2.3 -0.0 1.5 -0.2 -0.6 1.0
Ever depressed for a whole week 0.2 0.2 0.5 -0.7 -0.4 0.6 0.1 0.3
Unable to work because of sickness or disability 0.5 0.7 2.3 0.4 1.5 0.1 -0.2 1.0
Commuting to job workplace: Cycle 2.9 3.5 5.5 -1.6 0.9 2.4 2.4 1.7
Myopia 1.1 1.6 2.8 -1.7 0.6 1.2 1.4 1.3
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.5 0.6 -0.5 -0.4 -0.1 -0.7
Cholesterol lowering medication 1.0 1.5 2.5 1.3 -0.9 -1.2 -1.6 -1.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.5 -0.7 -0.1 0.3 -0.1 0.7
Pain experienced in last month 1.7 2.9 5.6 -1.6 1.6 1.0 2.4 1.6
Supplements: Calcium 0.7 0.8 1.7 -0.8 1.3 0.1 0.7 1.1
Basal cell carcinoma (self-reported) 0.6 0.7 1.3 0.8 -0.7 -1.2 -0.6 -1.0
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.5 0.7 0.2 -0.7 -0.3 -0.6
Deep venous thrombosis (DVT) (self-reported) 2.0 2.6 4.2 1.9 -0.5 -1.8 -2.1 -1.3
Heart disease (siblings) 0.4 0.6 1.0 0.9 0.1 -1.0 -0.5 -0.7
Alcohol drinker status: Previous 2.0 2.3 3.8 -1.8 0.1 1.9 1.6 1.3
Pack years of smoking 0.1 0.2 0.7 0.1 0.9 -0.0 -0.4 0.4
Impedance of whole body 0.4 1.8 6.1 -1.2 0.5 1.0 2.5 0.4
Leg fat mass (left) 0.3 1.2 4.6 0.9 0.2 -0.6 -2.1 0.0
Arm predicted mass (left) 0.2 0.9 2.2 0.6 0.8 -0.9 -1.5 0.6