Hub : Genes

MRPL30

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0388	0.0130	1.1e-12	0.046	0.043	0.043	0.044	0.044	1.2e-14	9.6e-14	9.2e-14	3.8e-14	3.8e-14
2	TCGA	Bladder Urothelial Carcinoma	0.1050	0.0610	1.2e-03	0.034	0.050	0.046	NA	0.040	6.5e-04	4.1e-05	8.8e-05	NA	2.4e-04
3	TCGA	Brain Lower Grade Glioma	0.0418	0.0217	3.2e-05	0.042	0.039	0.032	NA	0.031	1.5e-05	2.7e-05	1.2e-04	NA	1.5e-04
4	TCGA	Lung Adenocarcinoma	0.0601	0.0440	1.3e-05	0.051	0.050	0.044	NA	0.046	1.2e-06	1.6e-06	6.7e-06	NA	3.7e-06
5	TCGA	Prostate Adenocarcinoma	0.0836	0.0358	5.1e-08	0.053	0.072	0.069	NA	0.062	2.9e-06	5.2e-08	1.1e-07	NA	4.6e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	4.6	7.3	18.7	2.0	-4.3	0.1	-2.4	-2.9
Bipolar Disorder or Schizophrenia	0.9	2.2	7.8	0.3	-2.8	0.8	-0.8	-1.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.4	-0.1	0.2	-0.6	0.6
Depression (Nagel 2018)	0.1	0.2	0.3	-0.1	0.3	0.3	-0.6	0.6
Intelligence (Savage-Jansen 2018)	0.6	1.7	3.4	-0.8	1.8	0.3	1.8	1.1
Neuroticism (Nagel 2018)	0.2	0.6	1.5	-0.6	0.9	0.2	-0.1	1.2
Schizophrenia (2018)	0.3	0.7	1.6	-1.3	-0.1	0.9	0.9	0.6
Schizophrenia vs Biploar Disorder	5.0	6.6	15.0	-2.4	3.9	0.4	1.9	3.0
Worry (Nagel 2018)	0.5	1.1	3.1	-0.6	1.8	-0.8	-0.0	1.2
Alzheimer’s Disease (in mother)	2.2	2.6	3.1	1.7	-1.0	-1.7	-1.7	-1.8
Alzheimer’s Disease (in father)	1.8	2.0	3.5	-1.9	-0.6	1.8	1.1	1.1
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	0.2	-0.9	-0.1	-0.7	-0.5
Crohns Disease (2017)	0.1	0.3	0.5	0.4	-0.7	-0.4	-0.1	-0.7
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.3	-0.3	-0.2	-0.0	-0.1
Ulcerative Colitis (UC)	0.2	0.5	1.3	-1.1	0.4	0.3	0.4	0.8
Major Depression (MDD)	0.4	0.5	1.7	0.8	0.4	-0.1	-1.3	0.1
Reaction Time	0.2	0.3	0.9	0.4	0.0	-0.9	0.1	-0.7
Verbal and Numeric Reasoning (VNR)	2.2	5.3	7.6	-1.9	2.8	1.5	2.6	2.5
Breast Cancer	0.6	1.5	3.8	0.9	0.1	-1.6	-1.9	-0.6
Ovarian Cancer	0.6	0.8	1.7	-1.1	0.3	0.9	1.3	0.7
Prostate Cancer	0.4	0.6	1.1	-0.8	-0.5	0.9	1.1	0.0
Age at First Birth	0.4	0.5	0.8	-0.9	0.6	0.6	0.7	0.8
Bipolar Disorder (2011)	2.2	2.1	5.5	1.3	-2.4	0.6	-1.4	-1.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.5	-0.0	0.7	-0.5	-0.0	0.3
Coronary Artery Disease (CAD)	0.4	0.5	1.0	0.7	-0.5	-0.3	-1.0	-0.7
Crohns Disease (2012)	0.2	0.4	0.9	0.5	-0.7	-0.3	-0.1	-1.0
Mean Putamen Volume	1.0	1.1	1.9	-1.1	0.7	1.1	1.4	0.9
Fasting Glucose	0.1	0.1	0.2	0.1	0.4	-0.4	-0.2	0.1
HbA1C	0.2	0.3	0.8	-0.5	0.9	0.0	0.1	0.5
HDL Cholesterol	0.2	0.3	1.0	0.3	-1.0	0.1	-0.5	-0.5
LDL Cholesterol	0.1	0.2	0.5	0.4	0.1	-0.6	-0.7	-0.2
Lupus	0.0	0.1	0.2	0.1	-0.4	0.3	-0.1	0.0
Neuroticism (2016)	0.1	0.1	0.3	-0.0	0.5	-0.5	-0.3	0.2
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.4	1.0	-0.4	0.3	0.8
Rheumatoid Arthritis	0.5	0.7	2.0	0.4	-1.4	-0.1	-1.0	-0.8
Schizophrenia (2014)	0.1	0.2	0.4	-0.6	-0.1	0.5	0.1	0.4
Triglycerides	0.1	0.1	0.3	-0.2	0.5	-0.2	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	0.6	0.7	-1.0	-0.7	0.2
Ulcerative Colitis	0.4	0.6	2.1	-0.1	1.5	-0.3	0.1	0.8
Blood Eosinophil Count	0.3	2.4	7.8	-0.8	2.8	-0.2	1.1	1.5
Blood Platelet Count	0.0	0.1	0.1	0.1	0.3	-0.2	0.4	-0.0
Blood Red Count	0.6	5.5	9.1	2.2	-2.2	-1.9	-3.0	-2.3
Blood White Count	0.3	2.5	3.8	1.4	-2.0	-0.3	-1.8	-1.8
Heel T-Score	1.1	8.5	13.8	3.1	-3.7	-1.4	-2.2	-3.5
BMI	0.4	2.1	7.6	1.4	0.3	-1.0	-2.8	-0.1
Height	0.5	10.0	16.6	-2.8	4.1	1.3	3.5	3.4
Waist Hip Ratio (WHR)	1.0	4.5	7.1	-2.4	2.4	0.8	2.7	1.8
Systolic Blood Pressure	0.2	0.9	1.5	-0.9	0.7	1.2	0.9	1.0
Smoking Status	2.9	7.0	17.2	2.0	-4.1	-0.3	-1.8	-3.3
Allergy or Eczema	0.5	1.2	4.6	-0.1	2.1	-0.5	0.5	1.1
Cardiovascular Disease	0.1	0.3	0.7	0.1	-0.8	-0.0	-0.8	-0.1
Hypothyroidism (self reported)	0.6	1.5	3.2	1.6	-0.8	-0.3	-1.8	-0.8
Respiratory disease	1.6	3.5	8.9	-1.2	3.0	0.5	0.9	2.4
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.3	-0.3	1.1	-0.4	0.2	0.2
Lung FEV1/FVC ratio	6.5	32.8	50.8	5.5	-7.1	-3.1	-5.5	-6.5
Lung FVC	0.3	1.5	3.2	-0.9	0.7	1.8	0.9	1.5
Neuroticism	0.1	0.3	0.8	-0.4	0.5	-0.2	-0.5	0.9
Chronotype (morning person)	0.0	0.1	0.1	0.0	-0.4	0.2	0.3	-0.3
Hair Pigment	0.1	1.7	3.0	1.3	-1.6	-0.1	-1.7	-1.1
Tanning	0.0	0.6	1.0	-0.9	-0.0	1.0	0.9	0.5
Hand grip strength (left)	2.1	5.6	9.7	-1.9	3.1	0.9	2.5	2.8
Number of treatments/medications taken	0.2	0.4	0.6	0.6	-0.7	0.2	-0.8	-0.7
Average weekly spirits intake	0.3	0.3	0.7	0.4	-0.6	-0.4	-0.9	-0.4
Sensitivity / hurt feelings	0.3	0.5	1.7	-0.1	1.3	-0.6	-0.3	0.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	-1.2	0.2	0.9	0.4	1.1
Hearing difficulty/problems: Yes	0.5	0.8	1.9	-0.4	1.4	-0.5	1.1	0.6
Relative age of first facial hair	0.0	0.1	0.2	-0.2	0.2	0.3	0.3	0.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	2.2	1.5	-1.2	-0.8	-1.4	-1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.3	0.7	-0.4	0.0	0.5
Ever had hysterectomy (womb removed)	4.9	5.6	8.4	2.6	-1.8	-2.1	-2.9	-2.3
Systolic blood pressure, automated reading	0.3	0.8	1.4	0.8	1.2	-0.9	-1.2	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	0.2	-0.3	0.4	0.1	-0.3
Angina	0.1	0.1	0.4	0.6	0.2	0.1	-0.5	-0.1
Medication for hormone replacement therapy	1.6	1.8	3.8	1.4	-0.1	-1.9	-1.2	-1.3
Vitamin and mineral supplements	0.6	0.8	2.0	-0.8	-0.6	1.4	0.7	0.6
Supplements: Zinc	0.1	0.1	0.4	0.1	0.3	-0.6	0.2	-0.4
Medication: Co-codamol	0.5	0.6	0.9	0.7	-0.6	-0.7	-0.8	-1.0
Medication: Metformin	1.0	1.4	3.0	-1.1	1.7	0.7	0.9	1.2
Diabetes (father)	1.7	2.1	5.5	-0.6	2.3	0.8	0.9	1.8
Diabetes (mother)	1.2	1.5	2.8	0.7	-1.4	-1.3	-0.7	-1.7
Severe depression (siblings)	1.4	1.5	2.3	-1.5	0.3	1.5	0.8	1.5
Pack years adult smoking proportion	0.2	0.2	0.9	0.1	1.0	0.1	-0.3	0.5
Impedance of leg (right)	0.4	1.9	4.6	-1.3	-0.0	1.7	2.1	0.5
Leg fat-free mass (left)	0.2	0.9	1.6	0.2	1.3	-1.0	-1.0	0.8
Trunk fat percentage	0.1	0.5	1.6	0.5	0.4	-0.3	-1.3	0.3
Hand grip strength (right)	3.1	8.4	14.1	-2.3	3.8	1.3	3.1	3.3
Townsend deprivation index at recruitment	1.5	2.1	3.4	-1.5	0.9	1.8	1.4	1.4
Current tobacco smoking	5.0	8.2	17.4	2.2	-4.2	-0.8	-2.4	-3.5
Average weekly fortified wine intake	2.2	2.6	4.8	1.7	-0.4	-2.2	-1.3	-1.9
Maternal smoking around birth	1.5	2.1	7.0	0.6	-2.7	0.4	-1.0	-1.5
Fed-up feelings	0.2	0.4	0.8	-0.4	-0.9	0.5	-0.7	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.7	0.0	1.3	-0.6	-0.6	0.7
Relative age voice broke	0.2	0.3	0.7	-0.3	0.4	0.8	0.5	0.6
Taking other prescription medications	0.6	1.0	2.4	-1.0	0.0	1.5	1.0	0.5
Age when periods started (menarche)	1.6	4.0	7.4	-1.9	0.4	2.7	2.4	1.7
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	3.3	1.8	-0.3	-1.2	-1.8	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	6.8	2.5	-1.8	-1.7	-2.6	-2.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.6	-0.2	0.0	-0.7	-0.0
Qualifications: CSEs or equivalent	1.4	1.9	3.3	-1.1	1.1	1.8	0.5	1.8
Serious illness, injury or assault to yourself	0.4	0.4	0.7	0.7	-0.8	0.2	-0.8	-0.6
High blood pressure	0.1	0.1	0.3	-0.5	-0.3	0.4	-0.1	0.4
Hayfever, allergic rhinitis or eczema	0.8	1.8	5.9	-0.4	2.4	0.1	0.6	1.6
Multivitamins +/- minerals	0.6	0.7	1.7	0.8	-0.0	-1.3	-0.7	-0.9
Stomach or abdominal pain in last month	2.0	2.5	4.1	2.0	-0.7	-1.6	-1.8	-1.5
Supplements: Glucosamine	0.8	1.1	1.9	1.0	-0.9	-0.8	-1.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.9	1.3	0.1	-0.8	-1.4	-0.4
Medication: Atenolol	0.6	0.8	1.4	0.7	-1.1	-0.6	-0.7	-1.2
Medication: Levothyroxine sodium	0.4	0.7	1.8	0.7	-1.0	0.3	-1.3	-0.3
Sitting height	0.9	6.6	9.4	-2.4	3.0	1.2	2.7	3.1
Chronic bronchitis/emphysema (father)	4.2	5.0	6.1	2.3	-1.5	-2.5	-2.3	-2.4
High blood pressure (mother)	0.2	0.3	0.5	-0.6	0.1	0.7	0.6	0.6
Body mass index (BMI)	0.5	2.1	7.6	1.3	-0.5	-0.9	-2.8	-0.4
Impedance of leg (left)	0.6	2.9	6.7	-1.6	0.3	2.1	2.6	0.8
Leg predicted mass (left)	0.2	0.8	1.5	0.2	1.2	-1.0	-1.0	0.8
Trunk fat mass	0.1	0.6	1.6	0.4	0.8	-0.4	-1.3	0.5
Waist circumference	0.2	0.7	1.9	-0.2	1.4	-0.5	-0.8	0.9
Number of incorrect matches in round	0.6	1.1	4.1	0.2	-2.0	-0.1	-0.5	-0.9
Past tobacco smoking	0.6	1.1	3.1	-0.8	1.8	-0.6	0.5	1.0
Alcohol usually taken with meals	0.1	0.2	0.6	0.6	0.5	-0.8	0.1	0.0
Nervous feelings	0.2	0.4	0.7	-0.8	0.5	0.5	0.5	0.8
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	7.1	-2.7	0.9	2.5	1.6	2.6
Hearing difficulty/problems with background noise	0.8	1.3	4.0	-0.5	2.0	-0.1	0.5	1.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.5	0.1	0.7	0.3	-0.0	0.4
Had menopause	1.0	1.3	3.8	0.4	1.5	-1.9	0.0	-0.1
Had other major operations	2.2	2.7	4.3	2.1	-0.4	-1.9	-2.0	-1.2
Forced vital capacity (FVC)	2.7	10.6	13.8	-2.9	3.4	2.9	3.3	3.7
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.4	6.3	2.3	-2.2	-1.2	-2.5	-2.0
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.7	0.6	-1.2	-1.0	-0.8	-1.3
Qualifications: None of the above	2.6	5.5	11.2	1.5	-3.3	-0.9	-2.5	-2.6
Financial difficulties in last 2 years	0.4	0.6	1.9	0.3	1.4	-0.9	-0.1	0.1
Mouth/teeth dental problems	0.9	1.4	2.7	-1.2	0.9	1.2	0.9	1.6
Heart attack	0.4	0.5	0.7	0.9	-0.0	-0.8	-0.6	-0.9
Allergy	0.8	1.8	5.6	0.4	-2.4	-0.1	-0.3	-1.7
Pain all over the body in last month	4.7	5.0	9.4	-1.9	3.1	1.1	2.3	2.4
Diabetes (self-reported)	0.1	0.2	0.7	-0.2	0.9	-0.3	0.2	-0.1
Hayfever/allergic rhinitis (self-reported)	2.9	3.8	4.9	-2.0	1.7	1.8	2.0	2.2
Medication: Ramipril	0.0	0.0	0.1	-0.4	-0.1	-0.1	0.2	-0.2
Medication: Simvastatin	1.2	1.7	3.9	0.9	-2.0	-0.5	-1.1	-1.6
Fluid intelligence score	2.5	5.3	9.1	-1.8	2.7	1.4	3.0	2.2
Illnesses of siblings	0.4	0.5	2.2	0.4	1.5	-0.3	0.3	0.3
Neuroticism score	0.1	0.2	0.9	-0.0	-0.1	-0.4	-1.0	0.2
Weight	0.2	1.0	1.8	0.2	1.3	-0.7	-1.2	1.0
Impedance of arm (right)	0.1	0.6	2.7	-0.2	0.5	-0.0	1.6	-0.2
Arm fat percentage (right)	0.6	2.5	7.2	1.7	-0.6	-1.2	-2.7	-0.8
Trunk fat-free mass	0.1	0.6	1.0	0.4	0.9	-0.8	-1.0	0.7
Hip circumference	0.2	0.7	1.8	0.3	0.9	-0.4	-1.3	0.8
Time employed in main current job	0.7	0.8	1.1	-0.9	0.9	0.6	1.0	1.0
Alcohol intake versus 10 years previously	1.0	1.5	2.1	1.4	-1.1	-0.9	-1.4	-1.4
Father’s age at death	1.2	1.7	2.7	-1.2	0.7	1.6	1.6	1.1
Worrier / anxious feelings	0.6	1.2	3.0	-0.0	1.7	-1.6	-0.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.3	-0.0	0.2	-0.7	0.7
Falls in the last year	0.1	0.2	0.3	-0.6	-0.3	0.4	0.3	0.2
Hair/balding pattern: Pattern 3	0.4	0.5	1.8	0.5	0.7	-1.3	-0.3	-0.2
Number of live births	0.3	0.4	1.2	0.0	1.1	0.3	0.1	0.7
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	5.3	-1.5	2.0	2.1	2.0	2.3
Pulse rate	0.9	1.5	3.9	-1.0	2.0	-0.1	0.9	1.4
Happiness	1.2	1.5	1.8	-1.4	1.3	0.7	1.3	1.3
Noisy workplace	1.7	2.1	3.0	1.1	-1.6	-1.1	-1.5	-1.7
Qualifications: A levels/AS levels or equivalent	1.3	2.9	7.7	-0.7	2.8	-0.6	2.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	2.7	0.9	-1.6	-0.5	-0.9	-1.3
Mouth/teeth dental problems: Dentures	1.1	1.9	2.5	1.2	-1.6	-0.7	-1.6	-1.6
Asthma	0.6	1.1	3.0	-0.7	1.7	0.2	0.5	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	2.6	1.4	-1.6	-0.8	-1.6	-1.4
Medication: Cholesterol lowering	0.3	0.4	1.2	0.2	-1.1	0.5	-0.6	-0.5
Depression (self-reported)	1.6	2.0	4.0	-1.6	0.2	2.0	1.1	1.4
Medication: Lansoprazole	5.5	6.3	8.4	2.9	-1.2	-2.9	-2.9	-2.3
Prospective memory result	1.8	2.2	4.6	1.5	-1.0	-1.4	-2.2	-1.2
Lung cancer (father)	1.4	1.6	2.2	1.5	-0.7	-1.2	-1.5	-1.3
Illnesses of mother	0.4	0.5	0.8	-0.7	0.2	0.8	0.9	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.8	-1.1	0.6	1.9	1.4	1.4
Pulse wave Arterial Stiffness index	0.6	0.7	1.7	-0.6	1.3	0.3	0.3	1.2
Impedance of arm (left)	0.3	1.4	4.7	-0.9	1.1	0.3	2.2	0.5
Arm fat mass (right)	0.4	1.5	5.2	1.2	0.3	-1.0	-2.3	-0.0
Trunk predicted mass	0.1	0.6	1.1	0.4	0.9	-0.8	-1.0	0.7
Standing height	0.7	6.6	13.0	-2.1	3.6	0.3	2.8	2.8
Length of working week for main job	1.2	1.3	3.4	-0.9	1.8	-0.0	1.0	1.1
Exposure to tobacco smoke at home	2.5	2.8	4.8	1.9	0.3	-2.2	-2.0	-1.2
Breastfed as a baby	0.4	0.4	1.4	0.1	1.2	-0.5	0.1	0.7
Tense / ‘highly strung’	1.0	1.6	2.4	-1.6	0.5	1.3	1.1	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.3	-0.2	-1.5	0.4	-0.7	-0.6
Hair/balding pattern: Pattern 4	0.7	1.8	2.9	1.3	-1.7	-0.6	-1.5	-1.4
Birth weight of first child	0.0	0.0	0.0	-0.0	0.0	0.2	0.2	-0.1
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.0	0.7	0.4	0.7	0.6
Pulse wave reflection index	0.4	0.5	1.5	-0.4	1.2	0.3	0.4	0.8
Ever highly irritable/argumentative for 2 days	1.6	2.0	2.9	-1.7	0.7	1.6	1.0	1.6
Loud music exposure frequency	1.5	1.6	4.2	-1.4	-0.0	2.0	0.7	1.2
Qualifications: O levels/GCSEs or equivalent	3.8	6.1	17.9	-1.2	4.2	-0.3	2.4	2.3
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.3	-0.6	1.8	-0.2	1.0	0.8
Blood clot in the leg (DVT)	1.8	2.3	4.0	1.7	-0.4	-1.7	-2.0	-1.2
Medication: Paracetamol	0.2	0.3	0.6	0.3	0.8	-0.5	-0.6	0.2
Headache pain in last month	3.2	5.6	9.3	2.5	-1.8	-1.8	-3.0	-2.4
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.6	-0.6	1.6	0.2	1.0	1.0
Glaucoma (self-reported)	0.1	0.1	0.5	0.7	0.1	0.0	-0.0	-0.3
Gout (self-reported)	1.2	1.6	2.6	-1.5	1.3	0.6	1.1	1.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	3.8	1.5	-1.1	-0.7	-1.9	-1.2
Medication: Amlodipine	1.3	1.8	2.5	-1.3	1.0	1.6	1.3	1.5
Medication: Ventolin 100micrograms inhaler	1.5	2.0	3.2	-1.8	0.8	1.5	1.4	1.4
Birth weight	0.6	1.4	2.4	1.5	-0.2	-1.6	-1.0	-1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-0.7	0.2	1.2	0.3	0.9
High blood pressure (siblings)	0.4	0.6	1.8	0.1	-1.4	-0.1	-0.9	-0.7
Forced vital capacity (FVC), Best measure	1.7	6.1	7.5	-2.2	2.1	2.6	2.6	2.7
Body fat percentage	0.3	1.0	3.7	1.0	-0.0	-0.6	-1.9	-0.2
Leg fat percentage (right)	0.6	2.3	7.6	1.5	-0.6	-0.8	-2.8	-0.7
Arm fat-free mass (right)	0.1	0.7	1.2	0.1	1.1	-0.5	-1.0	1.0
Exposure to tobacco smoke outside home	0.9	1.2	3.6	0.7	1.9	-1.1	-0.7	0.3
Comparative body size at age 10	0.0	0.1	0.4	-0.0	0.2	-0.2	-0.6	0.3
Number of full brothers	1.7	2.1	3.1	1.2	-1.8	-0.9	-1.4	-1.8
Worry too long after embarrassment	0.2	0.4	0.9	-0.8	0.2	0.7	0.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.9	0.8	-1.7	0.1	-0.9	-1.1
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	-0.8	1.1	0.6	0.2	1.2
Number of children fathered	0.6	0.7	1.3	1.1	-0.3	-0.5	-1.1	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	3.0	-1.5	1.7	0.8	1.1	1.7
Age at first live birth	0.1	0.1	0.4	-0.2	0.1	-0.3	0.7	0.0
Pulse wave peak to peak time	0.5	0.5	1.1	0.5	-1.0	-0.4	-0.2	-1.0
Health satisfaction	0.5	0.7	1.5	-0.6	1.1	0.4	-0.4	1.2
Shortness of breath walking on level ground	0.3	0.4	0.9	0.2	-0.9	-0.6	-0.6	-0.5
Qualifications: College or University degree	1.7	5.4	11.3	-1.6	3.4	0.3	2.8	2.2
Eye problems/disorders: None of the above	0.5	0.6	1.3	-0.6	1.0	0.2	0.1	1.1
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.6	1.1	-1.1	-1.1	-0.9	-1.6
Emphysema/chronic bronchitis	0.1	0.1	0.2	-0.2	-0.3	0.2	-0.3	0.4
Medication for pain relief, constipation, heartburn	0.5	0.8	2.4	-1.0	0.5	0.6	1.6	0.4
Neck or shoulder pain in last month	0.4	0.5	1.5	0.0	-1.2	0.8	-0.6	-0.5
Medication: Blood pressure	0.1	0.1	0.4	-0.5	-0.3	0.6	0.1	0.2
Angina (self-reported)	0.2	0.3	0.8	0.9	-0.1	-0.1	-0.7	-0.5
Migraine (self-reported)	0.0	0.1	0.1	0.3	-0.1	0.3	0.1	-0.2
Medication: Ibuprofen	0.8	1.0	1.7	0.9	-1.3	-0.3	-1.1	-1.0
Medication: Allopurinol	0.3	0.4	0.6	-0.7	0.8	-0.1	0.3	0.8
Medication: Omeprazole	0.1	0.1	0.1	-0.3	-0.4	0.2	-0.4	0.2
Medication: Seretide 50 evohaler	5.5	6.3	9.8	-2.2	3.1	1.4	2.5	2.9
Mean time to correctly identify matches	0.1	0.3	1.0	0.1	0.6	-1.0	0.1	-0.2
Heart disease (mother)	1.1	1.4	2.6	1.6	-0.3	-1.1	-1.5	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.6	-0.6	-0.5	0.8	0.6	0.4
Whole body fat mass	0.2	0.7	2.8	0.6	0.4	-0.6	-1.7	0.3
Leg fat mass (right)	0.5	1.8	6.4	1.3	0.0	-0.9	-2.5	-0.3
Arm predicted mass (right)	0.1	0.7	1.3	0.0	1.1	-0.4	-0.9	1.1
Pulse rate, automated reading	0.1	0.2	0.5	0.0	0.6	-0.7	-0.3	0.2
Alcohol intake frequency.	2.0	4.7	6.8	2.4	-1.5	-1.8	-2.6	-2.4
Comparative height size at age 10	0.3	1.7	5.2	-0.7	2.3	-0.9	0.7	1.3
Number of full sisters	0.7	0.8	2.3	0.6	0.8	-1.5	-0.6	-0.6
Suffer from ‘nerves’	0.2	0.3	1.1	0.2	0.5	-1.0	-0.6	-0.1
Overall health rating	0.8	1.6	4.5	-0.7	2.1	-0.5	-0.5	1.6
Chest pain or discomfort	3.8	5.5	9.9	2.8	-1.1	-2.0	-3.1	-2.1
Had major operations	0.6	0.7	1.0	-0.8	0.4	0.9	0.8	1.0
Age at last live birth	0.1	0.1	0.4	-0.0	0.6	-0.5	0.3	0.1
Family relationship satisfaction	1.0	1.3	2.2	-1.3	1.3	0.4	1.5	0.7
Leg pain on walking	0.5	0.7	1.1	-0.6	1.0	0.7	0.7	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	1.6	-0.4	-1.3	1.2	0.0	0.1
Commuting to job workplace: Car/motor vehicle	5.1	5.9	7.8	2.5	-1.6	-2.8	-2.8	-2.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.7	-0.1	1.3	-0.1	0.2	0.8
Medication: Aspirin	0.2	0.2	0.6	-0.3	0.5	0.4	0.2	0.8
Supplements: Vitamin C	0.1	0.1	0.2	0.2	-0.3	0.5	-0.3	-0.3
Knee pain experienced in last month	5.2	8.0	11.0	2.9	-3.1	-1.8	-3.3	-2.8
Hypertension (Self-reported)	0.1	0.2	0.4	-0.6	0.0	0.5	0.0	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	4.3	1.8	-0.9	-1.8	-2.1	-1.1
Illnesses of father: Heart disease	0.6	0.9	1.5	1.2	0.5	-1.2	-1.1	-0.4
Illnesses of siblings: Diabetes	3.4	4.2	6.7	1.7	-2.6	-1.3	-1.8	-2.6
Smoking status: Previous	0.3	0.4	1.0	0.5	-1.0	0.8	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	2.0	2.8	-1.4	1.4	1.0	1.4	1.7
Whole body fat-free mass	0.1	0.8	1.3	0.3	1.2	-0.9	-1.1	0.8
Leg fat-free mass (right)	0.2	0.9	2.4	0.0	1.6	-0.9	-0.7	1.0
Arm fat percentage (left)	0.5	2.0	6.2	1.5	-0.3	-1.1	-2.5	-0.6
Average weekly red wine intake	1.4	2.0	2.9	-1.4	1.7	0.7	1.6	1.5
Handedness (chirality/laterality): Left-handed	3.8	4.6	6.0	-2.4	2.3	1.4	2.2	2.3
Mood swings	0.1	0.3	1.0	-0.1	-0.2	-0.2	-1.0	0.5
Loneliness, isolation	0.0	0.0	0.1	-0.4	-0.1	-0.1	-0.2	0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.4	0.8	0.1	-0.1	0.7
Ever had bowel cancer screening	1.9	2.2	3.5	1.9	-0.6	-1.8	-1.5	-1.3
Diabetes diagnosed by doctor	0.1	0.2	0.8	0.0	0.9	-0.1	0.0	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.3	-0.6	0.8	1.0	1.1	1.0
Friendships satisfaction	0.3	0.3	0.8	-0.4	0.9	0.1	0.7	0.4
Qualifications: nursing, teaching	0.2	0.3	0.6	0.5	0.6	-0.7	-0.2	-0.1
Commuting to job workplace: Walk	0.6	0.6	1.4	-0.3	1.2	0.4	0.9	0.7
Eye problems/disorders: Cataract	1.2	1.4	4.9	0.4	-2.2	0.5	-0.7	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	5.4	1.3	-2.2	-1.1	-0.9	-2.3
Medication for cholesterol	0.5	0.8	1.6	-0.9	-0.8	1.2	0.9	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	-0.1	-0.3	0.2	-0.3	0.2
Back pain experienced in last month	0.6	0.9	2.4	0.5	-1.0	-0.8	-1.6	-0.5
Mineral and other dietary supplements	1.2	1.6	2.4	-1.3	0.6	1.4	1.6	1.2
Breast cancer (self-reported)	0.9	1.1	3.9	-0.0	2.0	-0.4	0.2	1.2
Asthma (self-reported)	0.7	1.3	2.9	-0.9	1.7	0.5	0.7	1.5
Osteoporosis (self-reported)	0.8	1.0	2.3	0.7	-1.2	-1.0	-0.4	-1.5
Osteoarthritis (self-reported)	0.2	0.3	1.0	0.6	-0.1	0.0	-1.0	-0.2
Medication: Aspirin	0.3	0.3	0.6	-0.5	0.5	0.7	0.5	0.8
Medication: Gliclazide	0.4	0.5	1.7	-0.3	1.3	-0.1	0.2	0.7
Illnesses of father: None of the above (group 1)	1.1	1.3	2.5	-1.1	0.2	1.5	1.6	0.9
Smoking status: Current	5.9	9.3	19.5	2.4	-4.4	-0.9	-2.5	-3.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.2	1.1	-0.6	0.1	-1.0	-0.3
Whole body water mass	0.1	0.7	1.3	0.4	1.0	-0.9	-1.1	0.7
Leg predicted mass (right)	0.2	0.9	2.2	0.0	1.5	-0.9	-0.7	1.0
Arm fat mass (left)	0.4	1.6	5.2	1.2	0.2	-1.1	-2.3	-0.1
Number of self-reported non-cancer illnesses	0.1	0.3	0.6	-0.4	-0.7	0.8	-0.3	0.1
Average weekly champagne plus white wine intake	1.0	1.3	3.9	-1.4	0.3	0.5	2.0	0.7
Miserableness	0.2	0.3	1.2	0.3	-0.1	0.1	-1.1	0.4
Guilty feelings	2.4	3.5	6.0	2.2	-1.5	-1.4	-2.5	-1.6
Wears glasses or contact lenses	0.2	0.3	0.9	-0.4	-1.0	0.2	0.2	-0.5
Ever taken oral contraceptive pill	1.2	1.3	4.4	-0.7	-0.9	2.1	0.8	0.7
Hearing aid user	0.7	0.8	2.9	-0.3	1.7	-0.0	0.4	1.0
Mother’s age at death	0.2	0.3	1.0	0.5	0.2	-1.0	0.0	-0.4
Financial situation satisfaction	0.1	0.1	0.4	0.0	0.6	0.2	0.0	0.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.7	-0.0	-1.3	0.4	0.4	-0.8
Commuting to job workplace: Public transport	3.9	4.6	9.8	-2.4	1.0	1.9	3.1	1.8
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	1.5	-0.0	-1.2	-1.0	-1.1
Medication: Blood pressure	0.0	0.1	0.3	-0.2	0.3	-0.0	-0.1	0.6
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.6	0.5	-1.3	0.4	-1.2	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	1.0	-0.8	-0.7	-1.1	-1.1
High cholesterol (Self-reported)	1.0	1.9	4.0	1.0	-2.0	-0.6	-1.2	-1.5
Medication: Bendroflumethiazide	0.7	1.1	1.8	-1.1	0.9	1.1	0.7	1.3
Medication: Paracetamol	0.4	0.6	0.8	0.8	0.9	-0.9	-0.8	-0.0
Medication: Lisinopril	0.1	0.1	0.4	0.0	0.7	-0.2	0.4	0.0
Medication: Atorvastatin	0.3	0.4	0.9	0.4	-0.9	0.2	-1.0	-0.3
Illnesses of father: High blood pressure	0.5	0.6	2.2	-0.0	-1.5	0.3	-0.3	-0.8
Alcohol drinker status: Never	1.2	1.5	2.3	1.4	-0.2	-1.5	-1.3	-1.1
Ever smoked	0.8	1.4	2.8	1.1	-1.6	-0.4	-0.7	-1.7
Basal metabolic rate	0.2	0.9	1.6	0.2	1.3	-0.8	-1.1	0.9
Leg fat percentage (left)	0.4	1.5	5.6	1.2	-0.4	-0.5	-2.4	-0.5
Arm fat-free mass (left)	0.1	0.6	1.1	0.2	0.9	-0.5	-1.0	0.9
Number of operations (self-reported)	0.1	0.1	0.3	0.1	0.6	0.0	-0.1	0.2
Average weekly beer plus cider intake	0.5	0.7	1.5	-0.7	1.2	-0.2	0.9	0.9
Irritability	0.6	1.0	2.1	-1.5	0.2	1.2	0.9	0.9
Risk taking	0.3	0.4	1.2	-0.2	-1.1	0.7	0.4	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	-0.3	0.5	0.3	0.4	0.2
Fractured/broken bones in last 5 years	0.2	0.2	0.4	0.3	-0.4	-0.3	-0.7	-0.5
Age started oral contraceptive pill	3.4	4.3	11.4	-1.3	3.4	0.6	1.6	2.4
Diastolic blood pressure, automated reading	0.2	0.8	2.3	-0.0	1.5	-0.2	-0.6	1.0
Ever depressed for a whole week	0.2	0.2	0.5	-0.7	-0.4	0.6	0.1	0.3
Unable to work because of sickness or disability	0.5	0.7	2.3	0.4	1.5	0.1	-0.2	1.0
Commuting to job workplace: Cycle	2.9	3.5	5.5	-1.6	0.9	2.4	2.4	1.7
Myopia	1.1	1.6	2.8	-1.7	0.6	1.2	1.4	1.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	0.6	-0.5	-0.4	-0.1	-0.7
Cholesterol lowering medication	1.0	1.5	2.5	1.3	-0.9	-1.2	-1.6	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.7	-0.1	0.3	-0.1	0.7
Pain experienced in last month	1.7	2.9	5.6	-1.6	1.6	1.0	2.4	1.6
Supplements: Calcium	0.7	0.8	1.7	-0.8	1.3	0.1	0.7	1.1
Basal cell carcinoma (self-reported)	0.6	0.7	1.3	0.8	-0.7	-1.2	-0.6	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	0.7	0.2	-0.7	-0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	4.2	1.9	-0.5	-1.8	-2.1	-1.3
Heart disease (siblings)	0.4	0.6	1.0	0.9	0.1	-1.0	-0.5	-0.7
Alcohol drinker status: Previous	2.0	2.3	3.8	-1.8	0.1	1.9	1.6	1.3
Pack years of smoking	0.1	0.2	0.7	0.1	0.9	-0.0	-0.4	0.4
Impedance of whole body	0.4	1.8	6.1	-1.2	0.5	1.0	2.5	0.4
Leg fat mass (left)	0.3	1.2	4.6	0.9	0.2	-0.6	-2.1	0.0
Arm predicted mass (left)	0.2	0.9	2.2	0.6	0.8	-0.9	-1.5	0.6