TWAS hub - MRPL47

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2570	0.0610	6.7e-06	0.023	NA	0.035	NA	0.048	4.8e-03	NA	6.6e-04	NA	9.0e-05
2	GTEx	Esophagus Gastroesophageal Junction	0.2570	0.0870	4.4e-03	0.010	NA	0.068	NA	0.027	1.4e-01	NA	1.9e-03	NA	3.6e-02
3	GTEx	Nerve Tibial	0.1083	0.0382	9.7e-04	0.019	NA	-0.001	NA	0.011	1.5e-02	NA	4.3e-01	NA	5.2e-02
4	METSIM	Adipose	0.0683	0.0241	5.4e-04	0.050	0.031	0.042	0.051	0.044	5.7e-08	1.7e-05	5.0e-07	3.7e-08	2.9e-07
5	TCGA	Thyroid Carcinoma	0.0450	0.0270	1.0e-04	0.029	0.044	0.035	NA	0.033	7.8e-04	4.2e-05	2.3e-04	NA	3.3e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Heart disease (mother)	5.4	6.5	9.6	-2.7	-3.1	-2.8	-1.8	-2.2
Mother’s age at death	4.6	5.8	7.4	2.2	1.8	2.7	2.7	2.5
Had menopause	3.7	4.6	6.4	2.5	0.8	2.5	2.5	1.9
Pulse wave reflection index	3.6	4.4	6.4	2.5	1.1	2.2	2.0	2.3
Loud music exposure frequency	3.3	3.6	5.7	-2.4	-0.8	-2.3	-1.3	-2.1
Alzheimer’s Disease (in mother)	2.8	3.3	4.0	1.9	-1.5	2.0	2.0	1.6
Medication for hormone replacement therapy	2.8	3.2	3.6	-1.8	1.9	-1.9	-1.8	-1.5
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.2	-2.1	0.4	-2.3	-1.6	-1.7
Average weekly red wine intake	2.7	4.0	5.6	2.0	2.1	1.8	1.6	2.4
Fractured/broken bones in last 5 years	2.7	3.4	5.3	2.3	-0.8	2.0	2.0	1.8
Neuroticism (Nagel 2018)	2.4	5.5	8.9	1.2	-3.0	1.6	2.6	2.8
Mean Putamen Volume	2.4	2.7	5.8	-2.4	0.1	-1.7	-1.5	-1.5
Qualifications: O levels/GCSEs or equivalent	2.4	3.9	6.4	1.6	-1.1	2.1	2.5	2.2
Guilty feelings	2.4	3.6	5.2	1.0	-2.1	1.6	2.2	2.3
Commuting to job workplace: Car/motor vehicle	2.3	2.6	10.2	-0.5	-3.2	-1.0	-0.4	-1.2
Pain experienced in last month	2.2	3.6	5.5	2.2	2.0	2.4	1.2	1.5
Hair/balding pattern: Pattern 3	2.1	3.1	5.3	-2.3	-1.7	-2.0	-1.2	-1.4
Pulse wave Arterial Stiffness index	2.1	2.4	3.3	1.5	-0.1	1.8	1.8	1.8
Chronic bronchitis/emphysema (father)	2.0	2.3	3.3	-1.6	0.3	-1.8	-1.7	-1.7
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	15.5	-0.2	-3.9	-0.2	0.1	0.2
Pulse wave peak to peak time	2.0	2.4	3.3	-1.5	0.1	-1.8	-1.8	-1.8
Qualifications: nursing, teaching	2.0	3.2	7.0	1.4	0.3	1.8	2.6	1.9
Bipolar Disorder (2011)	1.8	1.8	2.8	-1.7	-0.9	-1.6	-1.6	0.0
Ever used hormone-replacement therapy (HRT)	1.8	2.2	3.1	1.2	1.4	1.5	1.8	1.6
Medication: Levothyroxine sodium	1.8	3.0	5.4	-1.4	0.8	-1.7	-2.0	-2.3
Neuroticism score	1.8	3.8	6.2	0.8	-2.5	1.4	2.1	2.3
Body Mass Index (BMI) (2010)	1.7	2.3	2.5	-1.6	1.4	-1.5	-1.6	-1.5
Worrier / anxious feelings	1.7	3.3	8.1	1.4	-2.8	1.4	1.5	1.5
Tense / ‘highly strung’	1.7	2.8	9.4	1.1	-3.1	1.1	1.1	1.1
Birth weight	1.7	3.7	5.9	1.9	-1.1	1.9	2.4	2.1
Supplements: Vitamin C	1.7	2.0	4.2	-1.1	0.3	-1.3	-1.7	-2.0
Illnesses of father: Heart disease	1.7	2.3	3.8	0.6	-1.5	1.5	1.7	1.9
Loneliness, isolation	1.7	2.3	9.7	-0.1	-3.1	0.1	0.9	1.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	3.6	1.1	0.6	1.3	1.9	1.8
Alcohol drinker status: Previous	1.7	1.9	3.4	1.1	-0.9	1.5	1.9	1.3
Fluid intelligence score	1.6	3.2	5.6	2.3	-0.3	2.4	1.6	1.7
Alcohol intake versus 10 years previously	1.6	2.4	3.3	-1.8	0.7	-1.4	-1.7	-1.8
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.1	1.3	-0.8	1.7	1.5	1.8
Medication for pain relief, constipation, heartburn	1.6	2.8	4.8	-1.4	-0.3	-1.5	-2.2	-2.2
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.7	-2.2	0.0	-1.6	-1.3	-0.9
Depression (Nagel 2018)	1.5	2.2	4.2	0.5	-1.5	0.9	2.1	1.8
Ulcerative Colitis	1.5	2.2	3.8	-2.0	-1.8	-1.5	-0.9	-0.9
Neuroticism	1.5	3.7	5.0	1.4	-1.8	1.7	2.2	2.2
Frequency of depressed mood in last 2 weeks	1.5	2.0	6.9	0.2	-2.6	0.5	1.2	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	4.0	1.8	-1.7	1.8	2.0	1.8
High blood pressure (siblings)	1.5	2.2	3.6	-1.5	-0.3	-1.5	-1.6	-1.9
Neck or shoulder pain in last month	1.5	2.1	4.2	-2.0	-0.7	-1.9	-1.2	-1.0
Mean time to correctly identify matches	1.5	2.8	9.9	0.4	3.1	0.8	1.4	1.1
Leg pain on walking	1.5	1.8	2.2	1.3	-1.2	1.4	1.5	1.4
Financial situation satisfaction	1.5	1.9	3.4	-1.6	-1.9	-1.5	-0.7	-0.8
Bipolar Disorder (2018)	1.4	2.3	10.6	-0.6	-3.3	-0.6	-0.0	0.3
Breast Cancer	1.4	3.4	6.1	-0.3	2.5	-0.8	-2.3	-2.3
Crohns Disease (2012)	1.4	2.3	6.8	-2.6	0.7	-1.7	-0.9	-0.7
Qualifications: College or University degree	1.4	4.5	6.9	1.9	0.1	2.4	2.6	2.6
Medication: Seretide 50 evohaler	1.4	1.7	2.2	-1.4	0.5	-1.5	-1.4	-1.4
Smoking status: Previous	1.4	2.2	8.2	-0.9	2.9	-1.0	-0.8	-0.5
Miserableness	1.4	2.4	5.8	-2.4	-1.0	-2.1	-0.7	-0.6
Depressed Affect (Nagel 2018)	1.3	2.8	6.0	0.1	-2.5	0.4	1.9	2.1
Worry (Nagel 2018)	1.3	2.7	5.0	1.1	-2.2	1.4	1.6	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	7.3	-0.9	-2.7	-0.5	0.4	0.1
Nervous feelings	1.3	2.4	6.6	1.1	-2.6	1.4	1.1	1.1
Medication: Omeprazole	1.3	1.6	3.0	0.8	0.6	1.0	1.7	1.7
Medication: Atorvastatin	1.3	1.6	2.3	-1.1	-0.8	-1.3	-1.5	-1.4
Major Depression (MDD)	1.2	1.5	3.6	0.9	0.0	1.0	1.9	1.4
Neuroticism (2016)	1.2	1.8	5.3	0.4	-2.3	0.8	1.4	0.8
Severe depression (siblings)	1.2	1.4	3.0	1.2	1.7	1.1	0.5	1.0
Average weekly fortified wine intake	1.2	1.5	2.0	1.0	-1.1	1.0	1.4	1.4
Fed-up feelings	1.2	2.1	5.9	0.3	-2.4	0.5	1.4	1.5
Shortness of breath walking on level ground	1.2	1.4	2.5	-1.3	-0.3	-1.6	-1.1	-1.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.8	0.4	1.5	0.9	1.1	1.7
Migraine (self-reported)	1.2	1.5	2.4	1.5	-0.0	1.4	1.3	1.1
Irritability	1.2	2.0	4.5	0.8	-0.6	1.4	1.7	2.1
Verbal and Numeric Reasoning (VNR)	1.1	2.8	4.7	2.0	-0.8	2.2	1.4	1.6
Leg fat-free mass (left)	1.1	5.6	27.7	-0.2	-5.3	-0.3	-0.1	-0.5
Leg predicted mass (left)	1.1	5.6	27.6	-0.1	-5.2	-0.3	-0.0	-0.5
Qualifications: None of the above	1.1	2.3	3.4	-1.3	1.1	-1.4	-1.8	-1.8
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.1	-1.3	0.3	-1.4	-1.0	-1.2
Arm fat-free mass (right)	1.1	5.5	25.7	-0.6	-5.1	-1.0	-0.1	-0.7
Arm predicted mass (right)	1.1	5.7	25.5	-0.8	-5.0	-1.2	-0.4	-0.9
Eye problems/disorders: Cataract	1.1	1.2	3.8	1.0	-1.9	0.8	0.7	0.5
Average weekly champagne plus white wine intake	1.1	1.5	3.1	1.3	-1.8	1.1	0.8	0.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.7	0.3	2.2	0.0	-0.9	-1.1
Arm fat-free mass (left)	1.1	5.6	27.1	-0.4	-5.2	-0.7	0.1	-0.5
Average weekly beer plus cider intake	1.1	1.5	2.6	-1.1	-1.0	-1.1	-1.6	-1.3
Ulcerative Colitis (UC)	1.0	1.9	3.0	-1.7	-1.5	-1.4	-1.0	-1.0
Rheumatoid Arthritis	1.0	1.3	2.3	0.9	-0.1	1.1	1.5	1.5
Pulse rate	1.0	1.7	2.9	-0.3	-1.5	-0.8	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	11.7	-1.1	-3.4	-1.0	-1.1	-0.8
Exposure to tobacco smoke at home	1.0	1.1	1.9	-1.2	-0.9	-1.4	-0.7	-1.0
Worry too long after embarrassment	1.0	1.6	3.3	0.9	-0.5	1.5	1.2	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.1	-0.4	-1.4	-0.8	-1.1	-1.3
Emphysema/chronic bronchitis	1.0	1.1	3.2	-0.2	-1.8	0.1	1.2	0.8
Hypertension (Self-reported)	1.0	2.9	3.4	-1.5	-1.6	-1.8	-1.8	-1.9
Leg fat-free mass (right)	1.0	5.5	27.3	-0.2	-5.2	-0.2	-0.1	-0.5
Whole body water mass	1.0	5.8	27.2	-0.6	-5.2	-0.8	-0.3	-0.8
Leg predicted mass (right)	1.0	5.5	27.0	-0.2	-5.2	-0.3	-0.2	-0.5
Arm fat mass (left)	1.0	4.0	18.3	0.5	-4.3	0.2	1.1	0.2
Basal metabolic rate	1.0	5.5	26.3	-0.5	-5.1	-0.7	-0.2	-0.7
Age started oral contraceptive pill	1.0	1.3	2.0	1.1	-0.6	1.3	1.4	1.1
Unable to work because of sickness or disability	1.0	1.3	2.7	-1.7	0.0	-1.4	-0.7	-1.2
Alzheimer’s Disease (including proxy)	0.9	1.3	2.2	1.4	-0.8	1.5	1.0	0.7
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.3	-1.5	0.3	-1.1	-1.0	-0.9
Average weekly spirits intake	0.9	1.1	2.8	-1.7	-0.8	-1.1	-0.8	-0.4
Supplements: Zinc	0.9	1.0	4.3	-0.3	2.1	-0.1	-0.6	-0.4
High blood pressure	0.9	2.4	2.9	-1.4	-1.5	-1.5	-1.6	-1.7
Supplements: Glucosamine	0.9	1.2	1.7	-1.0	1.2	-0.9	-1.3	-0.9
Hair/balding pattern: Pattern 2	0.9	1.1	3.4	0.9	1.9	0.8	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.3	1.8	-0.1	1.8	1.5	1.3
Mouth/teeth dental problems	0.9	1.5	3.9	-0.3	-0.5	-1.1	-1.3	-2.0
Allergy	0.9	2.0	2.8	1.5	-0.9	1.5	1.7	1.4
Weight	0.9	4.3	20.6	0.2	-4.5	0.0	0.8	0.2
Depression (self-reported)	0.9	1.0	2.2	0.5	-1.5	0.8	0.9	1.2
Length of working week for main job	0.9	0.9	2.5	0.7	-1.6	0.9	0.6	0.7
Whole body fat-free mass	0.9	5.3	24.4	-0.6	-4.9	-0.9	-0.4	-0.8
Long-standing illness, disability or infirmity	0.9	1.4	2.4	-1.2	-0.1	-1.3	-1.2	-1.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.4	-1.8	-0.1	-1.4	-1.1	-0.7
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	-0.8	0.3	-1.4	-1.3	-1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.4	0.3	2.1	0.2	-0.8	-0.7
Myopia	0.9	1.3	3.1	1.6	0.9	1.8	0.2	0.3
Arm predicted mass (left)	0.9	4.6	22.2	-0.4	-4.7	-0.7	0.1	-0.5
Pack years adult smoking proportion	0.8	1.3	4.1	0.5	-2.0	0.3	0.8	1.2
Impedance of leg (left)	0.8	3.8	13.5	1.4	3.7	1.0	0.9	1.2
Trunk fat mass	0.8	3.3	13.7	0.8	-3.7	0.4	1.3	0.6
Waist circumference	0.8	2.8	10.8	0.5	-3.3	0.4	1.3	0.8
Illnesses of siblings	0.8	1.1	1.9	1.1	1.4	0.9	0.8	1.0
Trunk fat-free mass	0.8	4.7	19.3	-1.0	-4.4	-1.2	-0.7	-1.1
Hip circumference	0.8	3.3	15.8	-0.6	-4.0	-0.3	0.5	0.1
Noisy workplace	0.8	1.0	1.4	-1.2	-1.1	-0.9	-0.8	-1.1
Prospective memory result	0.8	0.9	1.2	-1.0	-1.1	-1.0	-0.7	-1.0
Arm fat mass (right)	0.8	3.4	15.6	0.4	-4.0	0.2	1.2	0.3
Trunk predicted mass	0.8	4.7	19.3	-1.0	-4.4	-1.2	-0.7	-1.1
Forced vital capacity (FVC), Best measure	0.8	3.0	10.3	-0.7	-3.2	-1.0	-1.3	-1.2
Eye problems/disorders: None of the above	0.8	0.9	4.5	0.0	2.1	0.2	-0.0	-0.0
Illnesses of siblings: Diabetes	0.8	1.0	4.2	0.3	-2.1	0.6	0.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.0	0.0	-1.4	-0.5	-0.8	-1.3
Number of self-reported non-cancer illnesses	0.8	1.4	2.8	1.0	-1.7	0.9	1.3	0.8
Medication: Blood pressure	0.8	1.6	2.4	-1.3	-0.4	-1.6	-1.2	-1.4
Impedance of whole body	0.8	4.1	12.1	2.0	3.5	1.6	0.7	1.3
Bipolar Disorder or Schizophrenia	0.7	1.7	8.3	0.2	-2.9	0.1	0.1	0.3
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.0	2.0	-0.8	2.0	1.0	1.2
Coronary Artery Disease (CAD)	0.7	0.9	3.3	-0.5	-1.8	-0.3	0.6	0.7
HDL Cholesterol	0.7	1.2	2.6	1.6	0.2	1.2	0.9	1.0
Relative age of first facial hair	0.7	1.4	2.3	1.5	-0.5	1.5	0.8	1.2
Diabetes (mother)	0.7	0.9	4.1	-0.1	-2.0	-0.2	0.3	0.4
Impedance of leg (right)	0.7	3.5	12.1	1.4	3.5	1.0	1.0	1.3
Trunk fat percentage	0.7	2.7	7.5	1.1	-2.7	0.9	1.8	1.0
Hand grip strength (right)	0.7	1.8	6.3	-0.5	-2.5	-0.8	-1.1	-0.9
Stomach or abdominal pain in last month	0.7	0.9	3.6	-0.2	-1.9	-0.6	-0.5	-0.4
Body mass index (BMI)	0.7	3.1	13.8	-0.0	-3.7	0.1	1.2	0.4
Past tobacco smoking	0.7	1.3	6.1	0.1	-2.5	0.2	0.6	0.3
Financial difficulties in last 2 years	0.7	0.9	1.6	-0.7	-1.0	-1.3	-0.9	-0.6
Impedance of arm (right)	0.7	3.4	10.0	1.8	3.2	1.6	0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	2.5	-0.7	-1.6	-0.6	-0.8	-0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	3.2	0.6	1.8	0.6	0.9	1.1
Birth weight of first child	0.7	1.2	2.6	1.1	-0.2	0.8	1.6	1.3
Whole body fat mass	0.7	2.8	12.0	0.6	-3.5	0.2	1.1	0.4
Medication: Aspirin	0.7	0.9	2.1	0.0	0.5	0.7	1.4	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	3.5	-0.0	-1.9	0.3	0.6	0.3
Mood swings	0.7	1.3	3.3	0.3	-1.8	0.2	1.0	1.4
Friendships satisfaction	0.7	0.9	3.1	-1.8	-0.5	-1.0	-0.3	-0.1
Asthma (self-reported)	0.7	1.4	1.7	-1.3	0.9	-1.2	-1.2	-1.1
Commuting to job workplace: Public transport	0.7	0.8	1.6	1.2	0.7	1.3	0.6	0.7
Pack years of smoking	0.7	1.1	3.5	0.4	-1.9	0.2	0.7	1.1
Leg fat mass (left)	0.7	2.8	11.3	0.7	-3.4	0.3	1.4	0.6
Hand grip strength (left)	0.6	1.4	6.7	-0.2	-2.6	-0.4	-0.4	-0.4
Relative age voice broke	0.6	1.0	1.6	0.9	0.9	1.2	0.7	1.1
Father’s age at death	0.6	0.8	1.6	0.6	0.9	0.7	0.8	1.3
Happiness	0.6	0.7	2.0	-0.6	-0.1	-0.1	1.0	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.4	0.0	1.8	-0.4	-0.4	-0.1
Number of full brothers	0.6	0.8	1.9	-1.2	0.5	-0.5	-1.4	-0.4
Leg fat mass (right)	0.6	2.4	9.9	0.6	-3.1	0.1	1.3	0.5
Suffer from ‘nerves’	0.6	1.0	2.3	0.3	-1.5	0.9	0.9	1.1
Age at last live birth	0.6	0.8	1.9	-0.2	-0.9	-0.6	-1.4	-1.0
Knee pain experienced in last month	0.6	1.0	2.2	-1.2	-1.5	-1.0	-0.3	-0.5
Arm fat percentage (left)	0.6	2.3	9.0	0.8	-3.0	0.5	1.3	0.5
Ever had bowel cancer screening	0.6	0.7	1.2	0.6	0.6	0.8	1.1	1.0
Mineral and other dietary supplements	0.6	0.9	3.6	0.0	-1.9	-0.3	0.6	0.5
Medication: Gliclazide	0.6	0.6	1.0	0.8	1.0	0.8	0.6	0.6
Smoking status: Current	0.6	1.0	1.8	1.3	-1.1	1.3	0.5	0.5
Hearing aid user	0.6	0.7	2.6	-0.2	1.6	-0.2	-0.6	-0.7
Ever smoked	0.6	1.0	4.6	-0.4	2.1	-0.2	-0.6	-0.3
Supplements: Calcium	0.6	0.6	0.7	0.7	0.8	0.8	0.8	0.7
Irritable Bowel Disease (IBD)	0.5	1.2	3.7	-1.9	-1.0	-1.1	-0.4	-0.2
Prostate Cancer	0.5	0.7	1.8	1.3	-0.7	0.7	0.4	0.7
Fasting Glucose	0.5	0.5	1.7	1.3	-0.4	0.8	0.4	0.2
Blood Platelet Count	0.5	5.9	23.9	4.9	0.8	2.1	-0.6	-0.4
Smoking Status	0.5	1.1	3.6	1.0	1.9	0.9	0.2	0.3
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	-0.7	-1.3	-0.8	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	-1.1	-0.7	-1.0	-0.1	0.1
Current tobacco smoking	0.5	0.9	1.9	1.3	-0.4	1.4	0.5	0.5
Taking other prescription medications	0.5	0.8	1.5	-1.2	-1.1	-0.8	-0.2	-0.8
Multivitamins +/- minerals	0.5	0.6	1.1	-0.6	-0.1	-0.8	-1.1	-1.0
Medication: Atenolol	0.5	0.7	2.8	0.4	-1.7	0.4	0.4	0.3
Arm fat percentage (right)	0.5	1.9	6.5	0.7	-2.5	0.6	1.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	-1.2	-0.7	-1.0	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	5.9	-0.4	-2.4	-0.6	-1.0	-0.6
Asthma	0.5	1.0	1.8	-1.4	0.2	-1.2	-0.9	-0.9
Medication: Cholesterol lowering	0.5	0.8	2.3	-0.8	-1.5	-0.7	0.1	-0.6
Illnesses of mother	0.5	0.6	3.0	0.4	1.7	-0.0	-0.2	-0.1
Impedance of arm (left)	0.5	2.2	5.8	1.7	2.4	1.4	0.0	0.6
Blood clot in the leg (DVT)	0.5	0.7	1.0	-1.0	-0.6	-0.9	-0.8	-0.8
Body fat percentage	0.5	2.1	5.7	1.0	-2.4	0.7	1.6	0.9
Wheeze or whistling in the chest in last year	0.5	1.0	2.4	-1.4	-0.3	-1.6	-0.3	-0.5
Number of children fathered	0.5	0.5	1.3	1.1	0.0	0.8	0.6	0.5
Health satisfaction	0.5	0.6	1.8	0.2	-1.3	0.2	0.8	0.6
Medication: Ibuprofen	0.5	0.6	1.7	-0.4	1.3	-0.7	-0.5	-0.3
Medication: Allopurinol	0.5	0.6	1.1	-0.6	0.9	-0.8	-0.5	-1.0
Alcohol intake frequency.	0.5	1.2	2.6	-1.6	0.3	-0.9	-1.2	-1.1
Medication for cholesterol	0.5	0.7	1.3	0.9	-0.7	1.1	0.6	0.9
Medication: Aspirin	0.5	0.7	1.5	0.1	0.5	0.6	1.2	1.1
Medication: Bendroflumethiazide	0.5	0.8	1.7	0.1	-1.3	0.2	1.1	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.5	0.2	1.2	-0.2	-0.8	-0.8
Alzheimer’s Disease (in father)	0.4	0.4	0.7	-0.5	0.4	-0.7	-0.7	-0.8
LDL Cholesterol	0.4	0.6	2.3	0.2	-1.5	0.3	0.6	0.3
Heel T-Score	0.4	3.0	4.2	1.9	0.7	2.1	2.0	1.6
Vitamin and mineral supplements	0.4	0.6	1.1	0.6	0.1	0.7	1.1	1.0
Diabetes (father)	0.4	0.5	1.5	0.7	-1.2	0.6	0.6	-0.1
Maternal smoking around birth	0.4	0.6	1.3	-0.1	-0.4	-0.7	-1.1	-1.1
Qualifications: CSEs or equivalent	0.4	0.5	2.7	-0.0	-1.6	-0.1	-0.2	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	1.9	0.6	-1.4	0.5	0.3	-0.0
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.0	-0.4	0.8	-0.5	-1.4	-1.0
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.5	0.9	-0.3	-1.1	-0.7
Forced vital capacity (FVC)	0.4	1.6	6.6	-0.3	-2.6	-0.5	-0.9	-0.7
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-0.3	-1.1	-0.2	0.7	0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	-0.9	-0.2	-0.8	-0.7	-0.7
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	0.6	-0.0	1.2	1.3	1.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.0	0.1	1.7	0.3	-0.5	0.3
Gout (self-reported)	0.4	0.6	1.0	-0.2	1.0	-0.7	-0.5	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.1	-0.9	-0.2	-0.6	-1.1	-0.7
Leg fat percentage (right)	0.4	1.4	3.3	0.7	-1.8	0.3	1.6	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-0.4	1.2	-0.3	-0.8	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.3	0.2	1.5	0.1	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.3	0.4	-2.1	0.4	-0.2	0.0
Osteoporosis (self-reported)	0.4	0.5	1.0	1.0	-0.8	0.7	0.6	-0.0
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.6	-0.9	-0.7	-0.7	-0.6
Ever taken oral contraceptive pill	0.4	0.4	1.5	-0.6	-1.2	-0.2	0.2	0.2
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.2	-0.7	1.1	0.5	0.7
Leg fat percentage (left)	0.4	1.6	3.6	0.8	-1.9	0.5	1.6	0.8
Number of operations (self-reported)	0.4	0.5	1.1	0.1	-0.4	0.6	1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.7	-0.9	-0.7	-0.7	-0.7	-0.7
Crohns Disease (2017)	0.3	0.7	1.5	-0.9	-0.4	0.2	0.9	1.2
Reaction Time	0.3	0.6	2.4	0.1	1.6	0.2	0.7	0.4
HbA1C	0.3	0.4	0.6	0.6	0.4	0.5	0.7	0.8
Primary Biliary Cirrhosis	0.3	0.5	2.2	0.3	-1.5	0.1	0.2	0.2
Waist Hip Ratio (WHR)	0.3	1.3	3.2	1.8	0.3	1.0	1.1	1.1
Allergy or Eczema	0.3	0.8	1.9	-0.5	0.4	-0.5	-1.4	-1.2
Respiratory disease	0.3	0.7	0.9	-1.0	-0.1	-0.9	-0.9	-0.9
Lung FVC	0.3	1.5	3.9	0.9	-2.0	0.9	0.9	1.2
Angina	0.3	0.4	1.3	-0.8	-0.4	-1.1	0.1	0.1
Medication: Ramipril	0.3	0.3	0.9	-0.1	-0.5	-0.3	-0.6	-1.0
Falls in the last year	0.3	0.4	0.7	-0.8	0.0	-0.8	-0.6	-0.4
Breastfed as a baby	0.3	0.3	0.8	-0.1	-0.9	0.0	0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.3	1.2	-0.8	-0.4	-0.3
Peak expiratory flow (PEF)	0.3	0.7	3.2	-0.3	-1.8	0.0	-0.6	-0.1
Exposure to tobacco smoke outside home	0.3	0.5	0.9	-0.5	0.0	-0.8	-0.9	-0.7
Angina (self-reported)	0.3	0.4	1.4	-0.9	-0.2	-1.2	-0.0	0.0
Comparative height size at age 10	0.3	1.7	2.4	-1.3	-1.2	-1.5	-1.4	-1.0
Number of full sisters	0.3	0.4	1.0	0.4	-1.0	0.7	0.5	0.4
Overall health rating	0.3	0.7	2.1	0.4	-1.4	0.2	1.0	0.6
Chest pain or discomfort	0.3	0.4	0.9	-1.0	-0.5	-0.9	-0.4	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	-0.9	-0.3	-0.5	-0.6	-0.4
Diabetes diagnosed by doctor	0.3	0.5	1.1	-0.7	-1.1	-0.6	-0.5	-0.3
Medication: Paracetamol	0.3	0.4	1.1	-0.5	1.0	-0.7	-0.4	-0.3
Diastolic blood pressure, automated reading	0.3	1.1	1.9	1.4	-0.7	1.3	0.9	0.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.1	0.8	1.0	1.0	0.8	1.0
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.2	0.8	-0.4	-0.7	-0.7
Schizophrenia (2018)	0.2	0.4	1.3	0.7	-1.1	0.6	0.1	0.1
Age at First Birth	0.2	0.3	1.2	-0.2	1.1	0.3	-0.1	-0.1
Lupus	0.2	0.2	0.5	0.7	0.4	0.3	0.6	0.3
Blood Eosinophil Count	0.2	1.2	2.7	-0.1	0.5	-1.2	-1.6	-1.3
Blood White Count	0.2	1.8	3.5	0.2	1.0	-1.3	-1.7	-1.9
BMI	0.2	1.2	5.0	0.0	-2.2	-0.1	0.9	0.2
Height	0.2	3.8	13.3	2.1	-3.6	0.6	0.8	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.5	0.9	-1.0	-0.2	-0.7	-0.8	-0.5
Chronotype (morning person)	0.2	0.5	1.8	1.4	-0.3	0.5	-0.0	-0.6
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.3	0.8	0.6	0.2	0.5
Medication: Co-codamol	0.2	0.2	0.4	0.1	0.7	0.2	0.5	0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.4	0.1	-0.5	-0.6	-0.6
Sitting height	0.2	1.7	5.8	-0.3	-2.4	-0.6	-1.1	-0.9
Number of incorrect matches in round	0.2	0.4	1.1	-0.7	-1.0	-0.2	0.4	-0.2
Heart attack	0.2	0.2	0.4	0.3	-0.2	0.4	0.6	0.6
Pain all over the body in last month	0.2	0.2	1.1	-0.2	-1.1	-0.0	0.2	-0.1
Medication: Lansoprazole	0.2	0.2	0.3	-0.5	-0.2	-0.6	0.5	-0.2
Lung cancer (father)	0.2	0.3	0.4	0.5	-0.6	0.3	-0.4	-0.6
Standing height	0.2	1.8	7.9	0.6	-2.8	-0.1	-0.8	-0.5
Hair/balding pattern: Pattern 4	0.2	0.6	1.0	-0.4	-0.5	0.7	1.0	1.0
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	0.3	0.9	0.0	-0.3	-0.2
Headache pain in last month	0.2	0.3	0.5	-0.5	-0.7	-0.4	0.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.8	-0.9	-0.5	-0.7	-0.1	-0.9
Medication: Amlodipine	0.2	0.2	0.5	-0.0	-0.4	-0.2	-0.7	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.2	0.7	0.1	0.5	0.8
Pulse rate, automated reading	0.2	0.6	0.9	1.0	-0.7	0.4	-0.9	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.3	-0.4	1.1	-0.1	-0.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.1	0.2	-0.4	-0.8	-0.7
Breast cancer (self-reported)	0.2	0.3	0.8	0.4	-0.9	0.2	-0.1	-0.5
Medication: Lisinopril	0.2	0.3	0.6	0.5	-0.8	0.4	0.7	0.4
Alcohol drinker status: Never	0.2	0.3	1.1	-0.0	-1.0	-0.5	0.1	0.1
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.2	0.2	0.7	0.1	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	0.4	-0.3	0.4	0.6	0.5
Heart disease (siblings)	0.2	0.2	0.9	0.5	-1.0	0.1	-0.1	0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	0.1	0.7	0.0	0.1	-0.2
Ovarian Cancer	0.1	0.1	0.2	-0.2	-0.4	0.0	0.4	0.4
Schizophrenia (2014)	0.1	0.3	1.4	0.4	-1.2	0.2	0.1	0.1
Triglycerides	0.1	0.1	0.4	-0.1	0.6	-0.1	0.3	0.2
Blood Red Count	0.1	0.8	2.8	1.7	-0.0	0.8	-0.4	-0.5
Systolic Blood Pressure	0.1	0.5	2.0	-0.2	1.4	-0.5	-0.4	-0.4
Cardiovascular Disease	0.1	0.3	0.4	-0.4	-0.4	-0.6	-0.6	-0.6
Number of treatments/medications taken	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.5	0.0
Sensitivity / hurt feelings	0.1	0.2	0.8	-0.3	-0.9	-0.3	0.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.5	0.0	0.3	0.5	0.1
Medication: Metformin	0.1	0.1	0.4	-0.6	0.1	-0.4	0.1	0.1
Age when periods started (menarche)	0.1	0.3	0.8	0.9	-0.3	0.8	-0.2	0.3
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.2	0.3	-0.6	0.1	0.2
High blood pressure (mother)	0.1	0.1	0.3	-0.2	-0.3	-0.0	-0.5	-0.5
Alcohol usually taken with meals	0.1	0.1	0.3	0.4	0.5	0.1	-0.1	0.2
Had other major operations	0.1	0.2	0.3	0.3	0.6	0.4	-0.0	-0.4
Time employed in main current job	0.1	0.1	0.3	0.2	-0.5	0.2	0.3	-0.2
Medication: Paracetamol	0.1	0.2	0.4	-0.3	0.6	-0.6	-0.3	-0.1
Glaucoma (self-reported)	0.1	0.2	0.4	-0.1	-0.6	-0.2	-0.3	-0.5
Comparative body size at age 10	0.1	0.2	0.9	0.4	-1.0	0.3	-0.2	-0.1
Age at first live birth	0.1	0.2	0.8	0.9	-0.3	0.3	-0.4	0.1
Medication: Blood pressure	0.1	0.1	0.4	-0.0	-0.7	-0.4	0.0	-0.4
Had major operations	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.4	-0.1
Family relationship satisfaction	0.1	0.1	0.3	0.5	-0.2	0.1	-0.2	0.0
Commuting to job workplace: Walk	0.1	0.1	0.2	0.3	0.5	0.2	-0.2	0.3
Back pain experienced in last month	0.1	0.2	0.5	-0.7	-0.2	-0.5	0.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.1	0.1	-1.1	-0.3	-0.0	0.2
Wears glasses or contact lenses	0.1	0.1	0.2	0.0	0.1	0.4	0.4	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	-0.1	0.1	-0.4	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.2	-0.8	-0.3	0.5	-0.2
Risk taking	0.1	0.1	0.4	0.1	-0.7	-0.1	-0.0	-0.0
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	0.1	-0.2	0.0	0.3
Cholesterol lowering medication	0.1	0.2	0.4	0.5	0.6	0.2	0.3	0.0
Hypothyroidism (self reported)	0.0	0.1	0.3	-0.3	-0.2	0.0	0.5	-0.2
Lung FEV1/FVC ratio	0.0	0.0	0.1	0.1	0.2	-0.0	-0.0	-0.1
Hair Pigment	0.0	0.2	0.3	-0.2	0.4	0.4	-0.1	0.6
Tanning	0.0	0.4	0.9	0.6	-0.9	0.7	0.3	0.2
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.3	-0.1	0.2	0.4	0.3
Townsend deprivation index at recruitment	0.0	0.1	0.2	-0.4	0.2	0.2	0.1	0.3
Diabetes (self-reported)	0.0	0.1	0.2	-0.4	-0.0	-0.2	-0.4	-0.1
Medication: Simvastatin	0.0	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.4
Number of live births	0.0	0.1	0.1	-0.1	-0.3	0.3	0.2	0.2

Hub : Genes

MRPL47

Models

Trait associations