Hub : Genes

MRPL47

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2570	0.0610	6.7e-06	0.023	NA	0.035	NA	0.048	4.8e-03	NA	6.6e-04	NA	9.0e-05
2	GTEx	Esophagus Gastroesophageal Junction	0.2570	0.0870	4.4e-03	0.010	NA	0.068	NA	0.027	1.4e-01	NA	1.9e-03	NA	3.6e-02
3	GTEx	Nerve Tibial	0.1083	0.0382	9.7e-04	0.019	NA	-0.001	NA	0.011	1.5e-02	NA	4.3e-01	NA	5.2e-02
4	METSIM	Adipose	0.0683	0.0241	5.4e-04	0.050	0.031	0.042	0.051	0.044	5.7e-08	1.7e-05	5.0e-07	3.7e-08	2.9e-07
5	TCGA	Thyroid Carcinoma	0.0450	0.0270	1.0e-04	0.029	0.044	0.035	NA	0.033	7.8e-04	4.2e-05	2.3e-04	NA	3.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.4	2.3	10.6	-0.6	-3.3	-0.6	-0.0	0.3
Bipolar Disorder or Schizophrenia	0.7	1.7	8.3	0.2	-2.9	0.1	0.1	0.3
Depressed Affect (Nagel 2018)	1.3	2.8	6.0	0.1	-2.5	0.4	1.9	2.1
Depression (Nagel 2018)	1.5	2.2	4.2	0.5	-1.5	0.9	2.1	1.8
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.0	2.0	-0.8	2.0	1.0	1.2
Neuroticism (Nagel 2018)	2.4	5.5	8.9	1.2	-3.0	1.6	2.6	2.8
Schizophrenia (2018)	0.2	0.4	1.3	0.7	-1.1	0.6	0.1	0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.5	0.1	0.7	0.0	0.1	-0.2
Worry (Nagel 2018)	1.3	2.7	5.0	1.1	-2.2	1.4	1.6	1.6
Alzheimer’s Disease (in mother)	2.8	3.3	4.0	1.9	-1.5	2.0	2.0	1.6
Alzheimer’s Disease (in father)	0.4	0.4	0.7	-0.5	0.4	-0.7	-0.7	-0.8
Alzheimer’s Disease (including proxy)	0.9	1.3	2.2	1.4	-0.8	1.5	1.0	0.7
Crohns Disease (2017)	0.3	0.7	1.5	-0.9	-0.4	0.2	0.9	1.2
Irritable Bowel Disease (IBD)	0.5	1.2	3.7	-1.9	-1.0	-1.1	-0.4	-0.2
Ulcerative Colitis (UC)	1.0	1.9	3.0	-1.7	-1.5	-1.4	-1.0	-1.0
Major Depression (MDD)	1.2	1.5	3.6	0.9	0.0	1.0	1.9	1.4
Reaction Time	0.3	0.6	2.4	0.1	1.6	0.2	0.7	0.4
Verbal and Numeric Reasoning (VNR)	1.1	2.8	4.7	2.0	-0.8	2.2	1.4	1.6
Breast Cancer	1.4	3.4	6.1	-0.3	2.5	-0.8	-2.3	-2.3
Ovarian Cancer	0.1	0.1	0.2	-0.2	-0.4	0.0	0.4	0.4
Prostate Cancer	0.5	0.7	1.8	1.3	-0.7	0.7	0.4	0.7
Age at First Birth	0.2	0.3	1.2	-0.2	1.1	0.3	-0.1	-0.1
Bipolar Disorder (2011)	1.8	1.8	2.8	-1.7	-0.9	-1.6	-1.6	0.0
Body Mass Index (BMI) (2010)	1.7	2.3	2.5	-1.6	1.4	-1.5	-1.6	-1.5
Coronary Artery Disease (CAD)	0.7	0.9	3.3	-0.5	-1.8	-0.3	0.6	0.7
Crohns Disease (2012)	1.4	2.3	6.8	-2.6	0.7	-1.7	-0.9	-0.7
Mean Putamen Volume	2.4	2.7	5.8	-2.4	0.1	-1.7	-1.5	-1.5
Fasting Glucose	0.5	0.5	1.7	1.3	-0.4	0.8	0.4	0.2
HbA1C	0.3	0.4	0.6	0.6	0.4	0.5	0.7	0.8
HDL Cholesterol	0.7	1.2	2.6	1.6	0.2	1.2	0.9	1.0
LDL Cholesterol	0.4	0.6	2.3	0.2	-1.5	0.3	0.6	0.3
Lupus	0.2	0.2	0.5	0.7	0.4	0.3	0.6	0.3
Neuroticism (2016)	1.2	1.8	5.3	0.4	-2.3	0.8	1.4	0.8
Primary Biliary Cirrhosis	0.3	0.5	2.2	0.3	-1.5	0.1	0.2	0.2
Rheumatoid Arthritis	1.0	1.3	2.3	0.9	-0.1	1.1	1.5	1.5
Schizophrenia (2014)	0.1	0.3	1.4	0.4	-1.2	0.2	0.1	0.1
Triglycerides	0.1	0.1	0.4	-0.1	0.6	-0.1	0.3	0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.3	-1.5	0.3	-1.1	-1.0	-0.9
Ulcerative Colitis	1.5	2.2	3.8	-2.0	-1.8	-1.5	-0.9	-0.9
Blood Eosinophil Count	0.2	1.2	2.7	-0.1	0.5	-1.2	-1.6	-1.3
Blood Platelet Count	0.5	5.9	23.9	4.9	0.8	2.1	-0.6	-0.4
Blood Red Count	0.1	0.8	2.8	1.7	-0.0	0.8	-0.4	-0.5
Blood White Count	0.2	1.8	3.5	0.2	1.0	-1.3	-1.7	-1.9
Heel T-Score	0.4	3.0	4.2	1.9	0.7	2.1	2.0	1.6
BMI	0.2	1.2	5.0	0.0	-2.2	-0.1	0.9	0.2
Height	0.2	3.8	13.3	2.1	-3.6	0.6	0.8	0.6
Waist Hip Ratio (WHR)	0.3	1.3	3.2	1.8	0.3	1.0	1.1	1.1
Systolic Blood Pressure	0.1	0.5	2.0	-0.2	1.4	-0.5	-0.4	-0.4
Smoking Status	0.5	1.1	3.6	1.0	1.9	0.9	0.2	0.3
Allergy or Eczema	0.3	0.8	1.9	-0.5	0.4	-0.5	-1.4	-1.2
Cardiovascular Disease	0.1	0.3	0.4	-0.4	-0.4	-0.6	-0.6	-0.6
Hypothyroidism (self reported)	0.0	0.1	0.3	-0.3	-0.2	0.0	0.5	-0.2
Respiratory disease	0.3	0.7	0.9	-1.0	-0.1	-0.9	-0.9	-0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.5	0.9	-1.0	-0.2	-0.7	-0.8	-0.5
Lung FEV1/FVC ratio	0.0	0.0	0.1	0.1	0.2	-0.0	-0.0	-0.1
Lung FVC	0.3	1.5	3.9	0.9	-2.0	0.9	0.9	1.2
Neuroticism	1.5	3.7	5.0	1.4	-1.8	1.7	2.2	2.2
Chronotype (morning person)	0.2	0.5	1.8	1.4	-0.3	0.5	-0.0	-0.6
Hair Pigment	0.0	0.2	0.3	-0.2	0.4	0.4	-0.1	0.6
Tanning	0.0	0.4	0.9	0.6	-0.9	0.7	0.3	0.2
Hand grip strength (left)	0.6	1.4	6.7	-0.2	-2.6	-0.4	-0.4	-0.4
Number of treatments/medications taken	0.1	0.1	0.2	-0.5	-0.3	-0.3	0.5	0.0
Average weekly spirits intake	0.9	1.1	2.8	-1.7	-0.8	-1.1	-0.8	-0.4
Sensitivity / hurt feelings	0.1	0.2	0.8	-0.3	-0.9	-0.3	0.1	0.3
Frequency of depressed mood in last 2 weeks	1.5	2.0	6.9	0.2	-2.6	0.5	1.2	1.2
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.3	0.8	0.6	0.2	0.5
Relative age of first facial hair	0.7	1.4	2.3	1.5	-0.5	1.5	0.8	1.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.5	0.0	0.3	0.5	0.1
Ever used hormone-replacement therapy (HRT)	1.8	2.2	3.1	1.2	1.4	1.5	1.8	1.6
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	-0.7	-1.3	-0.8	0.2	-0.3
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.3	-0.1	0.2	0.4	0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	-1.1	-0.7	-1.0	-0.1	0.1
Angina	0.3	0.4	1.3	-0.8	-0.4	-1.1	0.1	0.1
Medication for hormone replacement therapy	2.8	3.2	3.6	-1.8	1.9	-1.9	-1.8	-1.5
Vitamin and mineral supplements	0.4	0.6	1.1	0.6	0.1	0.7	1.1	1.0
Supplements: Zinc	0.9	1.0	4.3	-0.3	2.1	-0.1	-0.6	-0.4
Medication: Co-codamol	0.2	0.2	0.4	0.1	0.7	0.2	0.5	0.6
Medication: Metformin	0.1	0.1	0.4	-0.6	0.1	-0.4	0.1	0.1
Diabetes (father)	0.4	0.5	1.5	0.7	-1.2	0.6	0.6	-0.1
Diabetes (mother)	0.7	0.9	4.1	-0.1	-2.0	-0.2	0.3	0.4
Severe depression (siblings)	1.2	1.4	3.0	1.2	1.7	1.1	0.5	1.0
Pack years adult smoking proportion	0.8	1.3	4.1	0.5	-2.0	0.3	0.8	1.2
Impedance of leg (right)	0.7	3.5	12.1	1.4	3.5	1.0	1.0	1.3
Leg fat-free mass (left)	1.1	5.6	27.7	-0.2	-5.3	-0.3	-0.1	-0.5
Trunk fat percentage	0.7	2.7	7.5	1.1	-2.7	0.9	1.8	1.0
Hand grip strength (right)	0.7	1.8	6.3	-0.5	-2.5	-0.8	-1.1	-0.9
Townsend deprivation index at recruitment	0.0	0.1	0.2	-0.4	0.2	0.2	0.1	0.3
Current tobacco smoking	0.5	0.9	1.9	1.3	-0.4	1.4	0.5	0.5
Average weekly fortified wine intake	1.2	1.5	2.0	1.0	-1.1	1.0	1.4	1.4
Maternal smoking around birth	0.4	0.6	1.3	-0.1	-0.4	-0.7	-1.1	-1.1
Fed-up feelings	1.2	2.1	5.9	0.3	-2.4	0.5	1.4	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	7.3	-0.9	-2.7	-0.5	0.4	0.1
Relative age voice broke	0.6	1.0	1.6	0.9	0.9	1.2	0.7	1.1
Taking other prescription medications	0.5	0.8	1.5	-1.2	-1.1	-0.8	-0.2	-0.8
Age when periods started (menarche)	0.1	0.3	0.8	0.9	-0.3	0.8	-0.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	-0.4	0.1	-0.5	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	4.0	1.8	-1.7	1.8	2.0	1.8
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.2	-2.1	0.4	-2.3	-1.6	-1.7
Qualifications: CSEs or equivalent	0.4	0.5	2.7	-0.0	-1.6	-0.1	-0.2	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	1.9	0.6	-1.4	0.5	0.3	-0.0
High blood pressure	0.9	2.4	2.9	-1.4	-1.5	-1.5	-1.6	-1.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.0	-0.4	0.8	-0.5	-1.4	-1.0
Multivitamins +/- minerals	0.5	0.6	1.1	-0.6	-0.1	-0.8	-1.1	-1.0
Stomach or abdominal pain in last month	0.7	0.9	3.6	-0.2	-1.9	-0.6	-0.5	-0.4
Supplements: Glucosamine	0.9	1.2	1.7	-1.0	1.2	-0.9	-1.3	-0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.2	0.3	-0.6	0.1	0.2
Medication: Atenolol	0.5	0.7	2.8	0.4	-1.7	0.4	0.4	0.3
Medication: Levothyroxine sodium	1.8	3.0	5.4	-1.4	0.8	-1.7	-2.0	-2.3
Sitting height	0.2	1.7	5.8	-0.3	-2.4	-0.6	-1.1	-0.9
Chronic bronchitis/emphysema (father)	2.0	2.3	3.3	-1.6	0.3	-1.8	-1.7	-1.7
High blood pressure (mother)	0.1	0.1	0.3	-0.2	-0.3	-0.0	-0.5	-0.5
Body mass index (BMI)	0.7	3.1	13.8	-0.0	-3.7	0.1	1.2	0.4
Impedance of leg (left)	0.8	3.8	13.5	1.4	3.7	1.0	0.9	1.2
Leg predicted mass (left)	1.1	5.6	27.6	-0.1	-5.2	-0.3	-0.0	-0.5
Trunk fat mass	0.8	3.3	13.7	0.8	-3.7	0.4	1.3	0.6
Waist circumference	0.8	2.8	10.8	0.5	-3.3	0.4	1.3	0.8
Number of incorrect matches in round	0.2	0.4	1.1	-0.7	-1.0	-0.2	0.4	-0.2
Past tobacco smoking	0.7	1.3	6.1	0.1	-2.5	0.2	0.6	0.3
Alcohol usually taken with meals	0.1	0.1	0.3	0.4	0.5	0.1	-0.1	0.2
Nervous feelings	1.3	2.4	6.6	1.1	-2.6	1.4	1.1	1.1
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	15.5	-0.2	-3.9	-0.2	0.1	0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.5	0.9	-0.3	-1.1	-0.7
Hair/balding pattern: Pattern 2	0.9	1.1	3.4	0.9	1.9	0.8	0.3	0.8
Had menopause	3.7	4.6	6.4	2.5	0.8	2.5	2.5	1.9
Had other major operations	0.1	0.2	0.3	0.3	0.6	0.4	-0.0	-0.4
Forced vital capacity (FVC)	0.4	1.6	6.6	-0.3	-2.6	-0.5	-0.9	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.3	1.8	-0.1	1.8	1.5	1.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-0.3	-1.1	-0.2	0.7	0.7
Qualifications: None of the above	1.1	2.3	3.4	-1.3	1.1	-1.4	-1.8	-1.8
Financial difficulties in last 2 years	0.7	0.9	1.6	-0.7	-1.0	-1.3	-0.9	-0.6
Mouth/teeth dental problems	0.9	1.5	3.9	-0.3	-0.5	-1.1	-1.3	-2.0
Heart attack	0.2	0.2	0.4	0.3	-0.2	0.4	0.6	0.6
Allergy	0.9	2.0	2.8	1.5	-0.9	1.5	1.7	1.4
Pain all over the body in last month	0.2	0.2	1.1	-0.2	-1.1	-0.0	0.2	-0.1
Diabetes (self-reported)	0.0	0.1	0.2	-0.4	-0.0	-0.2	-0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.8	-0.9	-0.2	-0.8	-0.7	-0.7
Medication: Ramipril	0.3	0.3	0.9	-0.1	-0.5	-0.3	-0.6	-1.0
Medication: Simvastatin	0.0	0.1	0.1	0.2	-0.1	-0.1	0.4	-0.4
Fluid intelligence score	1.6	3.2	5.6	2.3	-0.3	2.4	1.6	1.7
Illnesses of siblings	0.8	1.1	1.9	1.1	1.4	0.9	0.8	1.0
Neuroticism score	1.8	3.8	6.2	0.8	-2.5	1.4	2.1	2.3
Weight	0.9	4.3	20.6	0.2	-4.5	0.0	0.8	0.2
Impedance of arm (right)	0.7	3.4	10.0	1.8	3.2	1.6	0.3	0.9
Arm fat percentage (right)	0.5	1.9	6.5	0.7	-2.5	0.6	1.4	0.6
Trunk fat-free mass	0.8	4.7	19.3	-1.0	-4.4	-1.2	-0.7	-1.1
Hip circumference	0.8	3.3	15.8	-0.6	-4.0	-0.3	0.5	0.1
Time employed in main current job	0.1	0.1	0.3	0.2	-0.5	0.2	0.3	-0.2
Alcohol intake versus 10 years previously	1.6	2.4	3.3	-1.8	0.7	-1.4	-1.7	-1.8
Father’s age at death	0.6	0.8	1.6	0.6	0.9	0.7	0.8	1.3
Worrier / anxious feelings	1.7	3.3	8.1	1.4	-2.8	1.4	1.5	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	1.5	-1.2	-0.7	-1.0	-0.7	-1.0
Falls in the last year	0.3	0.4	0.7	-0.8	0.0	-0.8	-0.6	-0.4
Hair/balding pattern: Pattern 3	2.1	3.1	5.3	-2.3	-1.7	-2.0	-1.2	-1.4
Number of live births	0.0	0.1	0.1	-0.1	-0.3	0.3	0.2	0.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	5.9	-0.4	-2.4	-0.6	-1.0	-0.6
Pulse rate	1.0	1.7	2.9	-0.3	-1.5	-0.8	-1.6	-1.7
Happiness	0.6	0.7	2.0	-0.6	-0.1	-0.1	1.0	1.4
Noisy workplace	0.8	1.0	1.4	-1.2	-1.1	-0.9	-0.8	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.8	0.6	-0.0	1.2	1.3	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.9	2.5	-0.7	-1.6	-0.6	-0.8	-0.6
Mouth/teeth dental problems: Dentures	0.7	1.2	3.2	0.6	1.8	0.6	0.9	1.1
Asthma	0.5	1.0	1.8	-1.4	0.2	-1.2	-0.9	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.4	0.0	1.8	-0.4	-0.4	-0.1
Medication: Cholesterol lowering	0.5	0.8	2.3	-0.8	-1.5	-0.7	0.1	-0.6
Depression (self-reported)	0.9	1.0	2.2	0.5	-1.5	0.8	0.9	1.2
Medication: Lansoprazole	0.2	0.2	0.3	-0.5	-0.2	-0.6	0.5	-0.2
Prospective memory result	0.8	0.9	1.2	-1.0	-1.1	-1.0	-0.7	-1.0
Lung cancer (father)	0.2	0.3	0.4	0.5	-0.6	0.3	-0.4	-0.6
Illnesses of mother	0.5	0.6	3.0	0.4	1.7	-0.0	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	11.7	-1.1	-3.4	-1.0	-1.1	-0.8
Pulse wave Arterial Stiffness index	2.1	2.4	3.3	1.5	-0.1	1.8	1.8	1.8
Impedance of arm (left)	0.5	2.2	5.8	1.7	2.4	1.4	0.0	0.6
Arm fat mass (right)	0.8	3.4	15.6	0.4	-4.0	0.2	1.2	0.3
Trunk predicted mass	0.8	4.7	19.3	-1.0	-4.4	-1.2	-0.7	-1.1
Standing height	0.2	1.8	7.9	0.6	-2.8	-0.1	-0.8	-0.5
Length of working week for main job	0.9	0.9	2.5	0.7	-1.6	0.9	0.6	0.7
Exposure to tobacco smoke at home	1.0	1.1	1.9	-1.2	-0.9	-1.4	-0.7	-1.0
Breastfed as a baby	0.3	0.3	0.8	-0.1	-0.9	0.0	0.6	0.6
Tense / ‘highly strung’	1.7	2.8	9.4	1.1	-3.1	1.1	1.1	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.3	1.2	-0.8	-0.4	-0.3
Hair/balding pattern: Pattern 4	0.2	0.6	1.0	-0.4	-0.5	0.7	1.0	1.0
Birth weight of first child	0.7	1.2	2.6	1.1	-0.2	0.8	1.6	1.3
Peak expiratory flow (PEF)	0.3	0.7	3.2	-0.3	-1.8	0.0	-0.6	-0.1
Pulse wave reflection index	3.6	4.4	6.4	2.5	1.1	2.2	2.0	2.3
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	0.3	0.9	0.0	-0.3	-0.2
Loud music exposure frequency	3.3	3.6	5.7	-2.4	-0.8	-2.3	-1.3	-2.1
Qualifications: O levels/GCSEs or equivalent	2.4	3.9	6.4	1.6	-1.1	2.1	2.5	2.2
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.1	1.3	-0.8	1.7	1.5	1.8
Blood clot in the leg (DVT)	0.5	0.7	1.0	-1.0	-0.6	-0.9	-0.8	-0.8
Medication: Paracetamol	0.1	0.2	0.4	-0.3	0.6	-0.6	-0.3	-0.1
Headache pain in last month	0.2	0.3	0.5	-0.5	-0.7	-0.4	0.5	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.0	0.1	1.7	0.3	-0.5	0.3
Glaucoma (self-reported)	0.1	0.2	0.4	-0.1	-0.6	-0.2	-0.3	-0.5
Gout (self-reported)	0.4	0.6	1.0	-0.2	1.0	-0.7	-0.5	-1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	0.8	-0.9	-0.5	-0.7	-0.1	-0.9
Medication: Amlodipine	0.2	0.2	0.5	-0.0	-0.4	-0.2	-0.7	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.1	-0.9	-0.2	-0.6	-1.1	-0.7
Birth weight	1.7	3.7	5.9	1.9	-1.1	1.9	2.4	2.1
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.1	-1.3	0.3	-1.4	-1.0	-1.2
High blood pressure (siblings)	1.5	2.2	3.6	-1.5	-0.3	-1.5	-1.6	-1.9
Forced vital capacity (FVC), Best measure	0.8	3.0	10.3	-0.7	-3.2	-1.0	-1.3	-1.2
Body fat percentage	0.5	2.1	5.7	1.0	-2.4	0.7	1.6	0.9
Leg fat percentage (right)	0.4	1.4	3.3	0.7	-1.8	0.3	1.6	0.8
Arm fat-free mass (right)	1.1	5.5	25.7	-0.6	-5.1	-1.0	-0.1	-0.7
Exposure to tobacco smoke outside home	0.3	0.5	0.9	-0.5	0.0	-0.8	-0.9	-0.7
Comparative body size at age 10	0.1	0.2	0.9	0.4	-1.0	0.3	-0.2	-0.1
Number of full brothers	0.6	0.8	1.9	-1.2	0.5	-0.5	-1.4	-0.4
Worry too long after embarrassment	1.0	1.6	3.3	0.9	-0.5	1.5	1.2	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.6	0.2	0.7	0.1	0.5	0.8
Wheeze or whistling in the chest in last year	0.5	1.0	2.4	-1.4	-0.3	-1.6	-0.3	-0.5
Number of children fathered	0.5	0.5	1.3	1.1	0.0	0.8	0.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	2.1	-0.4	-1.4	-0.8	-1.1	-1.3
Age at first live birth	0.1	0.2	0.8	0.9	-0.3	0.3	-0.4	0.1
Pulse wave peak to peak time	2.0	2.4	3.3	-1.5	0.1	-1.8	-1.8	-1.8
Health satisfaction	0.5	0.6	1.8	0.2	-1.3	0.2	0.8	0.6
Shortness of breath walking on level ground	1.2	1.4	2.5	-1.3	-0.3	-1.6	-1.1	-1.2
Qualifications: College or University degree	1.4	4.5	6.9	1.9	0.1	2.4	2.6	2.6
Eye problems/disorders: None of the above	0.8	0.9	4.5	0.0	2.1	0.2	-0.0	-0.0
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.8	0.4	1.5	0.9	1.1	1.7
Emphysema/chronic bronchitis	1.0	1.1	3.2	-0.2	-1.8	0.1	1.2	0.8
Medication for pain relief, constipation, heartburn	1.6	2.8	4.8	-1.4	-0.3	-1.5	-2.2	-2.2
Neck or shoulder pain in last month	1.5	2.1	4.2	-2.0	-0.7	-1.9	-1.2	-1.0
Medication: Blood pressure	0.1	0.1	0.4	-0.0	-0.7	-0.4	0.0	-0.4
Angina (self-reported)	0.3	0.4	1.4	-0.9	-0.2	-1.2	-0.0	0.0
Migraine (self-reported)	1.2	1.5	2.4	1.5	-0.0	1.4	1.3	1.1
Medication: Ibuprofen	0.5	0.6	1.7	-0.4	1.3	-0.7	-0.5	-0.3
Medication: Allopurinol	0.5	0.6	1.1	-0.6	0.9	-0.8	-0.5	-1.0
Medication: Omeprazole	1.3	1.6	3.0	0.8	0.6	1.0	1.7	1.7
Medication: Seretide 50 evohaler	1.4	1.7	2.2	-1.4	0.5	-1.5	-1.4	-1.4
Mean time to correctly identify matches	1.5	2.8	9.9	0.4	3.1	0.8	1.4	1.1
Heart disease (mother)	5.4	6.5	9.6	-2.7	-3.1	-2.8	-1.8	-2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-0.4	1.2	-0.3	-0.8	-0.3
Whole body fat mass	0.7	2.8	12.0	0.6	-3.5	0.2	1.1	0.4
Leg fat mass (right)	0.6	2.4	9.9	0.6	-3.1	0.1	1.3	0.5
Arm predicted mass (right)	1.1	5.7	25.5	-0.8	-5.0	-1.2	-0.4	-0.9
Pulse rate, automated reading	0.2	0.6	0.9	1.0	-0.7	0.4	-0.9	-0.6
Alcohol intake frequency.	0.5	1.2	2.6	-1.6	0.3	-0.9	-1.2	-1.1
Comparative height size at age 10	0.3	1.7	2.4	-1.3	-1.2	-1.5	-1.4	-1.0
Number of full sisters	0.3	0.4	1.0	0.4	-1.0	0.7	0.5	0.4
Suffer from ‘nerves’	0.6	1.0	2.3	0.3	-1.5	0.9	0.9	1.1
Overall health rating	0.3	0.7	2.1	0.4	-1.4	0.2	1.0	0.6
Chest pain or discomfort	0.3	0.4	0.9	-1.0	-0.5	-0.9	-0.4	-0.3
Had major operations	0.1	0.1	0.2	-0.3	-0.4	-0.1	-0.4	-0.1
Age at last live birth	0.6	0.8	1.9	-0.2	-0.9	-0.6	-1.4	-1.0
Family relationship satisfaction	0.1	0.1	0.3	0.5	-0.2	0.1	-0.2	0.0
Leg pain on walking	1.5	1.8	2.2	1.3	-1.2	1.4	1.5	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.8	-0.9	-0.3	-0.5	-0.6	-0.4
Commuting to job workplace: Car/motor vehicle	2.3	2.6	10.2	-0.5	-3.2	-1.0	-0.4	-1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.3	0.2	1.5	0.1	0.2	0.1
Medication: Aspirin	0.7	0.9	2.1	0.0	0.5	0.7	1.4	1.3
Supplements: Vitamin C	1.7	2.0	4.2	-1.1	0.3	-1.3	-1.7	-2.0
Knee pain experienced in last month	0.6	1.0	2.2	-1.2	-1.5	-1.0	-0.3	-0.5
Hypertension (Self-reported)	1.0	2.9	3.4	-1.5	-1.6	-1.8	-1.8	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	3.5	-0.0	-1.9	0.3	0.6	0.3
Illnesses of father: Heart disease	1.7	2.3	3.8	0.6	-1.5	1.5	1.7	1.9
Illnesses of siblings: Diabetes	0.8	1.0	4.2	0.3	-2.1	0.6	0.3	0.1
Smoking status: Previous	1.4	2.2	8.2	-0.9	2.9	-1.0	-0.8	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	4.3	0.4	-2.1	0.4	-0.2	0.0
Whole body fat-free mass	0.9	5.3	24.4	-0.6	-4.9	-0.9	-0.4	-0.8
Leg fat-free mass (right)	1.0	5.5	27.3	-0.2	-5.2	-0.2	-0.1	-0.5
Arm fat percentage (left)	0.6	2.3	9.0	0.8	-3.0	0.5	1.3	0.5
Average weekly red wine intake	2.7	4.0	5.6	2.0	2.1	1.8	1.6	2.4
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.3	-0.4	1.1	-0.1	-0.1	0.1
Mood swings	0.7	1.3	3.3	0.3	-1.8	0.2	1.0	1.4
Loneliness, isolation	1.7	2.3	9.7	-0.1	-3.1	0.1	0.9	1.1
Long-standing illness, disability or infirmity	0.9	1.4	2.4	-1.2	-0.1	-1.3	-1.2	-1.6
Ever had bowel cancer screening	0.6	0.7	1.2	0.6	0.6	0.8	1.1	1.0
Diabetes diagnosed by doctor	0.3	0.5	1.1	-0.7	-1.1	-0.6	-0.5	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.1	0.2	-0.4	-0.8	-0.7
Friendships satisfaction	0.7	0.9	3.1	-1.8	-0.5	-1.0	-0.3	-0.1
Qualifications: nursing, teaching	2.0	3.2	7.0	1.4	0.3	1.8	2.6	1.9
Commuting to job workplace: Walk	0.1	0.1	0.2	0.3	0.5	0.2	-0.2	0.3
Eye problems/disorders: Cataract	1.1	1.2	3.8	1.0	-1.9	0.8	0.7	0.5
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.4	-1.8	-0.1	-1.4	-1.1	-0.7
Medication for cholesterol	0.5	0.7	1.3	0.9	-0.7	1.1	0.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.0	0.0	-1.4	-0.5	-0.8	-1.3
Back pain experienced in last month	0.1	0.2	0.5	-0.7	-0.2	-0.5	0.0	-0.1
Mineral and other dietary supplements	0.6	0.9	3.6	0.0	-1.9	-0.3	0.6	0.5
Breast cancer (self-reported)	0.2	0.3	0.8	0.4	-0.9	0.2	-0.1	-0.5
Asthma (self-reported)	0.7	1.4	1.7	-1.3	0.9	-1.2	-1.2	-1.1
Osteoporosis (self-reported)	0.4	0.5	1.0	1.0	-0.8	0.7	0.6	-0.0
Osteoarthritis (self-reported)	0.4	0.5	0.8	-0.6	-0.9	-0.7	-0.7	-0.6
Medication: Aspirin	0.5	0.7	1.5	0.1	0.5	0.6	1.2	1.1
Medication: Gliclazide	0.6	0.6	1.0	0.8	1.0	0.8	0.6	0.6
Illnesses of father: None of the above (group 1)	0.9	1.1	1.8	-0.8	0.3	-1.4	-1.3	-1.2
Smoking status: Current	0.6	1.0	1.8	1.3	-1.1	1.3	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.1	0.1	-1.1	-0.3	-0.0	0.2
Whole body water mass	1.0	5.8	27.2	-0.6	-5.2	-0.8	-0.3	-0.8
Leg predicted mass (right)	1.0	5.5	27.0	-0.2	-5.2	-0.3	-0.2	-0.5
Arm fat mass (left)	1.0	4.0	18.3	0.5	-4.3	0.2	1.1	0.2
Number of self-reported non-cancer illnesses	0.8	1.4	2.8	1.0	-1.7	0.9	1.3	0.8
Average weekly champagne plus white wine intake	1.1	1.5	3.1	1.3	-1.8	1.1	0.8	0.8
Miserableness	1.4	2.4	5.8	-2.4	-1.0	-2.1	-0.7	-0.6
Guilty feelings	2.4	3.6	5.2	1.0	-2.1	1.6	2.2	2.3
Wears glasses or contact lenses	0.1	0.1	0.2	0.0	0.1	0.4	0.4	0.4
Ever taken oral contraceptive pill	0.4	0.4	1.5	-0.6	-1.2	-0.2	0.2	0.2
Hearing aid user	0.6	0.7	2.6	-0.2	1.6	-0.2	-0.6	-0.7
Mother’s age at death	4.6	5.8	7.4	2.2	1.8	2.7	2.7	2.5
Financial situation satisfaction	1.5	1.9	3.4	-1.6	-1.9	-1.5	-0.7	-0.8
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.7	0.3	2.2	0.0	-0.9	-1.1
Commuting to job workplace: Public transport	0.7	0.8	1.6	1.2	0.7	1.3	0.6	0.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	-0.1	0.1	-0.4	-0.5
Medication: Blood pressure	0.8	1.6	2.4	-1.3	-0.4	-1.6	-1.2	-1.4
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.7	-2.2	0.0	-1.6	-1.3	-0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.4	0.3	2.1	0.2	-0.8	-0.7
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.2	-0.8	-0.3	0.5	-0.2
Medication: Bendroflumethiazide	0.5	0.8	1.7	0.1	-1.3	0.2	1.1	1.0
Medication: Paracetamol	0.3	0.4	1.1	-0.5	1.0	-0.7	-0.4	-0.3
Medication: Lisinopril	0.2	0.3	0.6	0.5	-0.8	0.4	0.7	0.4
Medication: Atorvastatin	1.3	1.6	2.3	-1.1	-0.8	-1.3	-1.5	-1.4
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.2	-0.7	1.1	0.5	0.7
Alcohol drinker status: Never	0.2	0.3	1.1	-0.0	-1.0	-0.5	0.1	0.1
Ever smoked	0.6	1.0	4.6	-0.4	2.1	-0.2	-0.6	-0.3
Basal metabolic rate	1.0	5.5	26.3	-0.5	-5.1	-0.7	-0.2	-0.7
Leg fat percentage (left)	0.4	1.6	3.6	0.8	-1.9	0.5	1.6	0.8
Arm fat-free mass (left)	1.1	5.6	27.1	-0.4	-5.2	-0.7	0.1	-0.5
Number of operations (self-reported)	0.4	0.5	1.1	0.1	-0.4	0.6	1.0	1.1
Average weekly beer plus cider intake	1.1	1.5	2.6	-1.1	-1.0	-1.1	-1.6	-1.3
Irritability	1.2	2.0	4.5	0.8	-0.6	1.4	1.7	2.1
Risk taking	0.1	0.1	0.4	0.1	-0.7	-0.1	-0.0	-0.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.5	0.2	1.2	-0.2	-0.8	-0.8
Fractured/broken bones in last 5 years	2.7	3.4	5.3	2.3	-0.8	2.0	2.0	1.8
Age started oral contraceptive pill	1.0	1.3	2.0	1.1	-0.6	1.3	1.4	1.1
Diastolic blood pressure, automated reading	0.3	1.1	1.9	1.4	-0.7	1.3	0.9	0.7
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	0.1	-0.2	0.0	0.3
Unable to work because of sickness or disability	1.0	1.3	2.7	-1.7	0.0	-1.4	-0.7	-1.2
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.2	0.2	0.7	0.1	0.6
Myopia	0.9	1.3	3.1	1.6	0.9	1.8	0.2	0.3
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.1	0.8	1.0	1.0	0.8	1.0
Cholesterol lowering medication	0.1	0.2	0.4	0.5	0.6	0.2	0.3	0.0
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	3.6	1.1	0.6	1.3	1.9	1.8
Pain experienced in last month	2.2	3.6	5.5	2.2	2.0	2.4	1.2	1.5
Supplements: Calcium	0.6	0.6	0.7	0.7	0.8	0.8	0.8	0.7
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.2	0.8	-0.4	-0.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.3	0.4	-0.3	0.4	0.6	0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.7	-0.9	-0.7	-0.7	-0.7	-0.7
Heart disease (siblings)	0.2	0.2	0.9	0.5	-1.0	0.1	-0.1	0.1
Alcohol drinker status: Previous	1.7	1.9	3.4	1.1	-0.9	1.5	1.9	1.3
Pack years of smoking	0.7	1.1	3.5	0.4	-1.9	0.2	0.7	1.1
Impedance of whole body	0.8	4.1	12.1	2.0	3.5	1.6	0.7	1.3
Leg fat mass (left)	0.7	2.8	11.3	0.7	-3.4	0.3	1.4	0.6
Arm predicted mass (left)	0.9	4.6	22.2	-0.4	-4.7	-0.7	0.1	-0.5