Hub : Genes

MRPL47

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.2570 0.0610 6.7e-06 0.023 NA 0.035 NA 0.048 4.8e-03 NA 6.6e-04 NA 9.0e-05
2 GTEx Esophagus Gastroesophageal Junction 0.2570 0.0870 4.4e-03 0.010 NA 0.068 NA 0.027 1.4e-01 NA 1.9e-03 NA 3.6e-02
3 GTEx Nerve Tibial 0.1083 0.0382 9.7e-04 0.019 NA -0.001 NA 0.011 1.5e-02 NA 4.3e-01 NA 5.2e-02
4 METSIM Adipose 0.0683 0.0241 5.4e-04 0.050 0.031 0.042 0.051 0.044 5.7e-08 1.7e-05 5.0e-07 3.7e-08 2.9e-07
5 TCGA Thyroid Carcinoma 0.0450 0.0270 1.0e-04 0.029 0.044 0.035 NA 0.033 7.8e-04 4.2e-05 2.3e-04 NA 3.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.4 2.3 10.6 -0.6 -3.3 -0.6 -0.0 0.3
Bipolar Disorder or Schizophrenia 0.7 1.7 8.3 0.2 -2.9 0.1 0.1 0.3
Depressed Affect (Nagel 2018) 1.3 2.8 6.0 0.1 -2.5 0.4 1.9 2.1
Depression (Nagel 2018) 1.5 2.2 4.2 0.5 -1.5 0.9 2.1 1.8
Intelligence (Savage-Jansen 2018) 0.7 2.2 4.0 2.0 -0.8 2.0 1.0 1.2
Neuroticism (Nagel 2018) 2.4 5.5 8.9 1.2 -3.0 1.6 2.6 2.8
Schizophrenia (2018) 0.2 0.4 1.3 0.7 -1.1 0.6 0.1 0.1
Schizophrenia vs Biploar Disorder 0.1 0.1 0.5 0.1 0.7 0.0 0.1 -0.2
Worry (Nagel 2018) 1.3 2.7 5.0 1.1 -2.2 1.4 1.6 1.6
Alzheimer’s Disease (in mother) 2.8 3.3 4.0 1.9 -1.5 2.0 2.0 1.6
Alzheimer’s Disease (in father) 0.4 0.4 0.7 -0.5 0.4 -0.7 -0.7 -0.8
Alzheimer’s Disease (including proxy) 0.9 1.3 2.2 1.4 -0.8 1.5 1.0 0.7
Crohns Disease (2017) 0.3 0.7 1.5 -0.9 -0.4 0.2 0.9 1.2
Irritable Bowel Disease (IBD) 0.5 1.2 3.7 -1.9 -1.0 -1.1 -0.4 -0.2
Ulcerative Colitis (UC) 1.0 1.9 3.0 -1.7 -1.5 -1.4 -1.0 -1.0
Major Depression (MDD) 1.2 1.5 3.6 0.9 0.0 1.0 1.9 1.4
Reaction Time 0.3 0.6 2.4 0.1 1.6 0.2 0.7 0.4
Verbal and Numeric Reasoning (VNR) 1.1 2.8 4.7 2.0 -0.8 2.2 1.4 1.6
Breast Cancer 1.4 3.4 6.1 -0.3 2.5 -0.8 -2.3 -2.3
Ovarian Cancer 0.1 0.1 0.2 -0.2 -0.4 0.0 0.4 0.4
Prostate Cancer 0.5 0.7 1.8 1.3 -0.7 0.7 0.4 0.7
Age at First Birth 0.2 0.3 1.2 -0.2 1.1 0.3 -0.1 -0.1
Bipolar Disorder (2011) 1.8 1.8 2.8 -1.7 -0.9 -1.6 -1.6 0.0
Body Mass Index (BMI) (2010) 1.7 2.3 2.5 -1.6 1.4 -1.5 -1.6 -1.5
Coronary Artery Disease (CAD) 0.7 0.9 3.3 -0.5 -1.8 -0.3 0.6 0.7
Crohns Disease (2012) 1.4 2.3 6.8 -2.6 0.7 -1.7 -0.9 -0.7
Mean Putamen Volume 2.4 2.7 5.8 -2.4 0.1 -1.7 -1.5 -1.5
Fasting Glucose 0.5 0.5 1.7 1.3 -0.4 0.8 0.4 0.2
HbA1C 0.3 0.4 0.6 0.6 0.4 0.5 0.7 0.8
HDL Cholesterol 0.7 1.2 2.6 1.6 0.2 1.2 0.9 1.0
LDL Cholesterol 0.4 0.6 2.3 0.2 -1.5 0.3 0.6 0.3
Lupus 0.2 0.2 0.5 0.7 0.4 0.3 0.6 0.3
Neuroticism (2016) 1.2 1.8 5.3 0.4 -2.3 0.8 1.4 0.8
Primary Biliary Cirrhosis 0.3 0.5 2.2 0.3 -1.5 0.1 0.2 0.2
Rheumatoid Arthritis 1.0 1.3 2.3 0.9 -0.1 1.1 1.5 1.5
Schizophrenia (2014) 0.1 0.3 1.4 0.4 -1.2 0.2 0.1 0.1
Triglycerides 0.1 0.1 0.4 -0.1 0.6 -0.1 0.3 0.2
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.3 -1.5 0.3 -1.1 -1.0 -0.9
Ulcerative Colitis 1.5 2.2 3.8 -2.0 -1.8 -1.5 -0.9 -0.9
Blood Eosinophil Count 0.2 1.2 2.7 -0.1 0.5 -1.2 -1.6 -1.3
Blood Platelet Count 0.5 5.9 23.9 4.9 0.8 2.1 -0.6 -0.4
Blood Red Count 0.1 0.8 2.8 1.7 -0.0 0.8 -0.4 -0.5
Blood White Count 0.2 1.8 3.5 0.2 1.0 -1.3 -1.7 -1.9
Heel T-Score 0.4 3.0 4.2 1.9 0.7 2.1 2.0 1.6
BMI 0.2 1.2 5.0 0.0 -2.2 -0.1 0.9 0.2
Height 0.2 3.8 13.3 2.1 -3.6 0.6 0.8 0.6
Waist Hip Ratio (WHR) 0.3 1.3 3.2 1.8 0.3 1.0 1.1 1.1
Systolic Blood Pressure 0.1 0.5 2.0 -0.2 1.4 -0.5 -0.4 -0.4
Smoking Status 0.5 1.1 3.6 1.0 1.9 0.9 0.2 0.3
Allergy or Eczema 0.3 0.8 1.9 -0.5 0.4 -0.5 -1.4 -1.2
Cardiovascular Disease 0.1 0.3 0.4 -0.4 -0.4 -0.6 -0.6 -0.6
Hypothyroidism (self reported) 0.0 0.1 0.3 -0.3 -0.2 0.0 0.5 -0.2
Respiratory disease 0.3 0.7 0.9 -1.0 -0.1 -0.9 -0.9 -0.9
Type 2 Diabetes (T2D) (2018) 0.2 0.5 0.9 -1.0 -0.2 -0.7 -0.8 -0.5
Lung FEV1/FVC ratio 0.0 0.0 0.1 0.1 0.2 -0.0 -0.0 -0.1
Lung FVC 0.3 1.5 3.9 0.9 -2.0 0.9 0.9 1.2
Neuroticism 1.5 3.7 5.0 1.4 -1.8 1.7 2.2 2.2
Chronotype (morning person) 0.2 0.5 1.8 1.4 -0.3 0.5 -0.0 -0.6
Hair Pigment 0.0 0.2 0.3 -0.2 0.4 0.4 -0.1 0.6
Tanning 0.0 0.4 0.9 0.6 -0.9 0.7 0.3 0.2
Hand grip strength (left) 0.6 1.4 6.7 -0.2 -2.6 -0.4 -0.4 -0.4
Number of treatments/medications taken 0.1 0.1 0.2 -0.5 -0.3 -0.3 0.5 0.0
Average weekly spirits intake 0.9 1.1 2.8 -1.7 -0.8 -1.1 -0.8 -0.4
Sensitivity / hurt feelings 0.1 0.2 0.8 -0.3 -0.9 -0.3 0.1 0.3
Frequency of depressed mood in last 2 weeks 1.5 2.0 6.9 0.2 -2.6 0.5 1.2 1.2
Hearing difficulty/problems: Yes 0.2 0.3 0.7 0.3 0.8 0.6 0.2 0.5
Relative age of first facial hair 0.7 1.4 2.3 1.5 -0.5 1.5 0.8 1.2
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 0.5 0.0 0.3 0.5 0.1
Ever used hormone-replacement therapy (HRT) 1.8 2.2 3.1 1.2 1.4 1.5 1.8 1.6
Ever had hysterectomy (womb removed) 0.5 0.6 1.7 -0.7 -1.3 -0.8 0.2 -0.3
Systolic blood pressure, automated reading 0.0 0.1 0.2 0.3 -0.1 0.2 0.4 0.3
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.1 -1.1 -0.7 -1.0 -0.1 0.1
Angina 0.3 0.4 1.3 -0.8 -0.4 -1.1 0.1 0.1
Medication for hormone replacement therapy 2.8 3.2 3.6 -1.8 1.9 -1.9 -1.8 -1.5
Vitamin and mineral supplements 0.4 0.6 1.1 0.6 0.1 0.7 1.1 1.0
Supplements: Zinc 0.9 1.0 4.3 -0.3 2.1 -0.1 -0.6 -0.4
Medication: Co-codamol 0.2 0.2 0.4 0.1 0.7 0.2 0.5 0.6
Medication: Metformin 0.1 0.1 0.4 -0.6 0.1 -0.4 0.1 0.1
Diabetes (father) 0.4 0.5 1.5 0.7 -1.2 0.6 0.6 -0.1
Diabetes (mother) 0.7 0.9 4.1 -0.1 -2.0 -0.2 0.3 0.4
Severe depression (siblings) 1.2 1.4 3.0 1.2 1.7 1.1 0.5 1.0
Pack years adult smoking proportion 0.8 1.3 4.1 0.5 -2.0 0.3 0.8 1.2
Impedance of leg (right) 0.7 3.5 12.1 1.4 3.5 1.0 1.0 1.3
Leg fat-free mass (left) 1.1 5.6 27.7 -0.2 -5.3 -0.3 -0.1 -0.5
Trunk fat percentage 0.7 2.7 7.5 1.1 -2.7 0.9 1.8 1.0
Hand grip strength (right) 0.7 1.8 6.3 -0.5 -2.5 -0.8 -1.1 -0.9
Townsend deprivation index at recruitment 0.0 0.1 0.2 -0.4 0.2 0.2 0.1 0.3
Current tobacco smoking 0.5 0.9 1.9 1.3 -0.4 1.4 0.5 0.5
Average weekly fortified wine intake 1.2 1.5 2.0 1.0 -1.1 1.0 1.4 1.4
Maternal smoking around birth 0.4 0.6 1.3 -0.1 -0.4 -0.7 -1.1 -1.1
Fed-up feelings 1.2 2.1 5.9 0.3 -2.4 0.5 1.4 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 7.3 -0.9 -2.7 -0.5 0.4 0.1
Relative age voice broke 0.6 1.0 1.6 0.9 0.9 1.2 0.7 1.1
Taking other prescription medications 0.5 0.8 1.5 -1.2 -1.1 -0.8 -0.2 -0.8
Age when periods started (menarche) 0.1 0.3 0.8 0.9 -0.3 0.8 -0.2 0.3
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.4 0.1 -0.5 -0.6 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 4.0 1.8 -1.7 1.8 2.0 1.8
Tinnitus: Yes, but not now, but have in the past 2.8 3.0 5.2 -2.1 0.4 -2.3 -1.6 -1.7
Qualifications: CSEs or equivalent 0.4 0.5 2.7 -0.0 -1.6 -0.1 -0.2 -0.1
Serious illness, injury or assault to yourself 0.4 0.5 1.9 0.6 -1.4 0.5 0.3 -0.0
High blood pressure 0.9 2.4 2.9 -1.4 -1.5 -1.5 -1.6 -1.7
Hayfever, allergic rhinitis or eczema 0.4 0.8 2.0 -0.4 0.8 -0.5 -1.4 -1.0
Multivitamins +/- minerals 0.5 0.6 1.1 -0.6 -0.1 -0.8 -1.1 -1.0
Stomach or abdominal pain in last month 0.7 0.9 3.6 -0.2 -1.9 -0.6 -0.5 -0.4
Supplements: Glucosamine 0.9 1.2 1.7 -1.0 1.2 -0.9 -1.3 -0.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.4 -0.2 0.3 -0.6 0.1 0.2
Medication: Atenolol 0.5 0.7 2.8 0.4 -1.7 0.4 0.4 0.3
Medication: Levothyroxine sodium 1.8 3.0 5.4 -1.4 0.8 -1.7 -2.0 -2.3
Sitting height 0.2 1.7 5.8 -0.3 -2.4 -0.6 -1.1 -0.9
Chronic bronchitis/emphysema (father) 2.0 2.3 3.3 -1.6 0.3 -1.8 -1.7 -1.7
High blood pressure (mother) 0.1 0.1 0.3 -0.2 -0.3 -0.0 -0.5 -0.5
Body mass index (BMI) 0.7 3.1 13.8 -0.0 -3.7 0.1 1.2 0.4
Impedance of leg (left) 0.8 3.8 13.5 1.4 3.7 1.0 0.9 1.2
Leg predicted mass (left) 1.1 5.6 27.6 -0.1 -5.2 -0.3 -0.0 -0.5
Trunk fat mass 0.8 3.3 13.7 0.8 -3.7 0.4 1.3 0.6
Waist circumference 0.8 2.8 10.8 0.5 -3.3 0.4 1.3 0.8
Number of incorrect matches in round 0.2 0.4 1.1 -0.7 -1.0 -0.2 0.4 -0.2
Past tobacco smoking 0.7 1.3 6.1 0.1 -2.5 0.2 0.6 0.3
Alcohol usually taken with meals 0.1 0.1 0.3 0.4 0.5 0.1 -0.1 0.2
Nervous feelings 1.3 2.4 6.6 1.1 -2.6 1.4 1.1 1.1
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 15.5 -0.2 -3.9 -0.2 0.1 0.2
Hearing difficulty/problems with background noise 0.4 0.6 1.3 -0.5 0.9 -0.3 -1.1 -0.7
Hair/balding pattern: Pattern 2 0.9 1.1 3.4 0.9 1.9 0.8 0.3 0.8
Had menopause 3.7 4.6 6.4 2.5 0.8 2.5 2.5 1.9
Had other major operations 0.1 0.2 0.3 0.3 0.6 0.4 -0.0 -0.4
Forced vital capacity (FVC) 0.4 1.6 6.6 -0.3 -2.6 -0.5 -0.9 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.3 1.8 -0.1 1.8 1.5 1.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 -0.3 -1.1 -0.2 0.7 0.7
Qualifications: None of the above 1.1 2.3 3.4 -1.3 1.1 -1.4 -1.8 -1.8
Financial difficulties in last 2 years 0.7 0.9 1.6 -0.7 -1.0 -1.3 -0.9 -0.6
Mouth/teeth dental problems 0.9 1.5 3.9 -0.3 -0.5 -1.1 -1.3 -2.0
Heart attack 0.2 0.2 0.4 0.3 -0.2 0.4 0.6 0.6
Allergy 0.9 2.0 2.8 1.5 -0.9 1.5 1.7 1.4
Pain all over the body in last month 0.2 0.2 1.1 -0.2 -1.1 -0.0 0.2 -0.1
Diabetes (self-reported) 0.0 0.1 0.2 -0.4 -0.0 -0.2 -0.4 -0.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.8 -0.9 -0.2 -0.8 -0.7 -0.7
Medication: Ramipril 0.3 0.3 0.9 -0.1 -0.5 -0.3 -0.6 -1.0
Medication: Simvastatin 0.0 0.1 0.1 0.2 -0.1 -0.1 0.4 -0.4
Fluid intelligence score 1.6 3.2 5.6 2.3 -0.3 2.4 1.6 1.7
Illnesses of siblings 0.8 1.1 1.9 1.1 1.4 0.9 0.8 1.0
Neuroticism score 1.8 3.8 6.2 0.8 -2.5 1.4 2.1 2.3
Weight 0.9 4.3 20.6 0.2 -4.5 0.0 0.8 0.2
Impedance of arm (right) 0.7 3.4 10.0 1.8 3.2 1.6 0.3 0.9
Arm fat percentage (right) 0.5 1.9 6.5 0.7 -2.5 0.6 1.4 0.6
Trunk fat-free mass 0.8 4.7 19.3 -1.0 -4.4 -1.2 -0.7 -1.1
Hip circumference 0.8 3.3 15.8 -0.6 -4.0 -0.3 0.5 0.1
Time employed in main current job 0.1 0.1 0.3 0.2 -0.5 0.2 0.3 -0.2
Alcohol intake versus 10 years previously 1.6 2.4 3.3 -1.8 0.7 -1.4 -1.7 -1.8
Father’s age at death 0.6 0.8 1.6 0.6 0.9 0.7 0.8 1.3
Worrier / anxious feelings 1.7 3.3 8.1 1.4 -2.8 1.4 1.5 1.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 1.5 -1.2 -0.7 -1.0 -0.7 -1.0
Falls in the last year 0.3 0.4 0.7 -0.8 0.0 -0.8 -0.6 -0.4
Hair/balding pattern: Pattern 3 2.1 3.1 5.3 -2.3 -1.7 -2.0 -1.2 -1.4
Number of live births 0.0 0.1 0.1 -0.1 -0.3 0.3 0.2 0.2
Forced expiratory volume in 1-second (FEV1) 0.5 1.5 5.9 -0.4 -2.4 -0.6 -1.0 -0.6
Pulse rate 1.0 1.7 2.9 -0.3 -1.5 -0.8 -1.6 -1.7
Happiness 0.6 0.7 2.0 -0.6 -0.1 -0.1 1.0 1.4
Noisy workplace 0.8 1.0 1.4 -1.2 -1.1 -0.9 -0.8 -1.1
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.8 0.6 -0.0 1.2 1.3 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.9 2.5 -0.7 -1.6 -0.6 -0.8 -0.6
Mouth/teeth dental problems: Dentures 0.7 1.2 3.2 0.6 1.8 0.6 0.9 1.1
Asthma 0.5 1.0 1.8 -1.4 0.2 -1.2 -0.9 -0.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 3.4 0.0 1.8 -0.4 -0.4 -0.1
Medication: Cholesterol lowering 0.5 0.8 2.3 -0.8 -1.5 -0.7 0.1 -0.6
Depression (self-reported) 0.9 1.0 2.2 0.5 -1.5 0.8 0.9 1.2
Medication: Lansoprazole 0.2 0.2 0.3 -0.5 -0.2 -0.6 0.5 -0.2
Prospective memory result 0.8 0.9 1.2 -1.0 -1.1 -1.0 -0.7 -1.0
Lung cancer (father) 0.2 0.3 0.4 0.5 -0.6 0.3 -0.4 -0.6
Illnesses of mother 0.5 0.6 3.0 0.4 1.7 -0.0 -0.2 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.0 3.2 11.7 -1.1 -3.4 -1.0 -1.1 -0.8
Pulse wave Arterial Stiffness index 2.1 2.4 3.3 1.5 -0.1 1.8 1.8 1.8
Impedance of arm (left) 0.5 2.2 5.8 1.7 2.4 1.4 0.0 0.6
Arm fat mass (right) 0.8 3.4 15.6 0.4 -4.0 0.2 1.2 0.3
Trunk predicted mass 0.8 4.7 19.3 -1.0 -4.4 -1.2 -0.7 -1.1
Standing height 0.2 1.8 7.9 0.6 -2.8 -0.1 -0.8 -0.5
Length of working week for main job 0.9 0.9 2.5 0.7 -1.6 0.9 0.6 0.7
Exposure to tobacco smoke at home 1.0 1.1 1.9 -1.2 -0.9 -1.4 -0.7 -1.0
Breastfed as a baby 0.3 0.3 0.8 -0.1 -0.9 0.0 0.6 0.6
Tense / ‘highly strung’ 1.7 2.8 9.4 1.1 -3.1 1.1 1.1 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 1.4 -0.3 1.2 -0.8 -0.4 -0.3
Hair/balding pattern: Pattern 4 0.2 0.6 1.0 -0.4 -0.5 0.7 1.0 1.0
Birth weight of first child 0.7 1.2 2.6 1.1 -0.2 0.8 1.6 1.3
Peak expiratory flow (PEF) 0.3 0.7 3.2 -0.3 -1.8 0.0 -0.6 -0.1
Pulse wave reflection index 3.6 4.4 6.4 2.5 1.1 2.2 2.0 2.3
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.8 0.3 0.9 0.0 -0.3 -0.2
Loud music exposure frequency 3.3 3.6 5.7 -2.4 -0.8 -2.3 -1.3 -2.1
Qualifications: O levels/GCSEs or equivalent 2.4 3.9 6.4 1.6 -1.1 2.1 2.5 2.2
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 3.1 1.3 -0.8 1.7 1.5 1.8
Blood clot in the leg (DVT) 0.5 0.7 1.0 -1.0 -0.6 -0.9 -0.8 -0.8
Medication: Paracetamol 0.1 0.2 0.4 -0.3 0.6 -0.6 -0.3 -0.1
Headache pain in last month 0.2 0.3 0.5 -0.5 -0.7 -0.4 0.5 0.4
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 3.0 0.1 1.7 0.3 -0.5 0.3
Glaucoma (self-reported) 0.1 0.2 0.4 -0.1 -0.6 -0.2 -0.3 -0.5
Gout (self-reported) 0.4 0.6 1.0 -0.2 1.0 -0.7 -0.5 -1.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 0.8 -0.9 -0.5 -0.7 -0.1 -0.9
Medication: Amlodipine 0.2 0.2 0.5 -0.0 -0.4 -0.2 -0.7 -0.7
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.1 -0.9 -0.2 -0.6 -1.1 -0.7
Birth weight 1.7 3.7 5.9 1.9 -1.1 1.9 2.4 2.1
Chronic bronchitis/emphysema (mother) 1.1 1.3 2.1 -1.3 0.3 -1.4 -1.0 -1.2
High blood pressure (siblings) 1.5 2.2 3.6 -1.5 -0.3 -1.5 -1.6 -1.9
Forced vital capacity (FVC), Best measure 0.8 3.0 10.3 -0.7 -3.2 -1.0 -1.3 -1.2
Body fat percentage 0.5 2.1 5.7 1.0 -2.4 0.7 1.6 0.9
Leg fat percentage (right) 0.4 1.4 3.3 0.7 -1.8 0.3 1.6 0.8
Arm fat-free mass (right) 1.1 5.5 25.7 -0.6 -5.1 -1.0 -0.1 -0.7
Exposure to tobacco smoke outside home 0.3 0.5 0.9 -0.5 0.0 -0.8 -0.9 -0.7
Comparative body size at age 10 0.1 0.2 0.9 0.4 -1.0 0.3 -0.2 -0.1
Number of full brothers 0.6 0.8 1.9 -1.2 0.5 -0.5 -1.4 -0.4
Worry too long after embarrassment 1.0 1.6 3.3 0.9 -0.5 1.5 1.2 1.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.6 0.2 0.7 0.1 0.5 0.8
Wheeze or whistling in the chest in last year 0.5 1.0 2.4 -1.4 -0.3 -1.6 -0.3 -0.5
Number of children fathered 0.5 0.5 1.3 1.1 0.0 0.8 0.6 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 2.1 -0.4 -1.4 -0.8 -1.1 -1.3
Age at first live birth 0.1 0.2 0.8 0.9 -0.3 0.3 -0.4 0.1
Pulse wave peak to peak time 2.0 2.4 3.3 -1.5 0.1 -1.8 -1.8 -1.8
Health satisfaction 0.5 0.6 1.8 0.2 -1.3 0.2 0.8 0.6
Shortness of breath walking on level ground 1.2 1.4 2.5 -1.3 -0.3 -1.6 -1.1 -1.2
Qualifications: College or University degree 1.4 4.5 6.9 1.9 0.1 2.4 2.6 2.6
Eye problems/disorders: None of the above 0.8 0.9 4.5 0.0 2.1 0.2 -0.0 -0.0
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.8 0.4 1.5 0.9 1.1 1.7
Emphysema/chronic bronchitis 1.0 1.1 3.2 -0.2 -1.8 0.1 1.2 0.8
Medication for pain relief, constipation, heartburn 1.6 2.8 4.8 -1.4 -0.3 -1.5 -2.2 -2.2
Neck or shoulder pain in last month 1.5 2.1 4.2 -2.0 -0.7 -1.9 -1.2 -1.0
Medication: Blood pressure 0.1 0.1 0.4 -0.0 -0.7 -0.4 0.0 -0.4
Angina (self-reported) 0.3 0.4 1.4 -0.9 -0.2 -1.2 -0.0 0.0
Migraine (self-reported) 1.2 1.5 2.4 1.5 -0.0 1.4 1.3 1.1
Medication: Ibuprofen 0.5 0.6 1.7 -0.4 1.3 -0.7 -0.5 -0.3
Medication: Allopurinol 0.5 0.6 1.1 -0.6 0.9 -0.8 -0.5 -1.0
Medication: Omeprazole 1.3 1.6 3.0 0.8 0.6 1.0 1.7 1.7
Medication: Seretide 50 evohaler 1.4 1.7 2.2 -1.4 0.5 -1.5 -1.4 -1.4
Mean time to correctly identify matches 1.5 2.8 9.9 0.4 3.1 0.8 1.4 1.1
Heart disease (mother) 5.4 6.5 9.6 -2.7 -3.1 -2.8 -1.8 -2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.5 -0.4 1.2 -0.3 -0.8 -0.3
Whole body fat mass 0.7 2.8 12.0 0.6 -3.5 0.2 1.1 0.4
Leg fat mass (right) 0.6 2.4 9.9 0.6 -3.1 0.1 1.3 0.5
Arm predicted mass (right) 1.1 5.7 25.5 -0.8 -5.0 -1.2 -0.4 -0.9
Pulse rate, automated reading 0.2 0.6 0.9 1.0 -0.7 0.4 -0.9 -0.6
Alcohol intake frequency. 0.5 1.2 2.6 -1.6 0.3 -0.9 -1.2 -1.1
Comparative height size at age 10 0.3 1.7 2.4 -1.3 -1.2 -1.5 -1.4 -1.0
Number of full sisters 0.3 0.4 1.0 0.4 -1.0 0.7 0.5 0.4
Suffer from ‘nerves’ 0.6 1.0 2.3 0.3 -1.5 0.9 0.9 1.1
Overall health rating 0.3 0.7 2.1 0.4 -1.4 0.2 1.0 0.6
Chest pain or discomfort 0.3 0.4 0.9 -1.0 -0.5 -0.9 -0.4 -0.3
Had major operations 0.1 0.1 0.2 -0.3 -0.4 -0.1 -0.4 -0.1
Age at last live birth 0.6 0.8 1.9 -0.2 -0.9 -0.6 -1.4 -1.0
Family relationship satisfaction 0.1 0.1 0.3 0.5 -0.2 0.1 -0.2 0.0
Leg pain on walking 1.5 1.8 2.2 1.3 -1.2 1.4 1.5 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 0.8 -0.9 -0.3 -0.5 -0.6 -0.4
Commuting to job workplace: Car/motor vehicle 2.3 2.6 10.2 -0.5 -3.2 -1.0 -0.4 -1.2
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 2.3 0.2 1.5 0.1 0.2 0.1
Medication: Aspirin 0.7 0.9 2.1 0.0 0.5 0.7 1.4 1.3
Supplements: Vitamin C 1.7 2.0 4.2 -1.1 0.3 -1.3 -1.7 -2.0
Knee pain experienced in last month 0.6 1.0 2.2 -1.2 -1.5 -1.0 -0.3 -0.5
Hypertension (Self-reported) 1.0 2.9 3.4 -1.5 -1.6 -1.8 -1.8 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 3.5 -0.0 -1.9 0.3 0.6 0.3
Illnesses of father: Heart disease 1.7 2.3 3.8 0.6 -1.5 1.5 1.7 1.9
Illnesses of siblings: Diabetes 0.8 1.0 4.2 0.3 -2.1 0.6 0.3 0.1
Smoking status: Previous 1.4 2.2 8.2 -0.9 2.9 -1.0 -0.8 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 4.3 0.4 -2.1 0.4 -0.2 0.0
Whole body fat-free mass 0.9 5.3 24.4 -0.6 -4.9 -0.9 -0.4 -0.8
Leg fat-free mass (right) 1.0 5.5 27.3 -0.2 -5.2 -0.2 -0.1 -0.5
Arm fat percentage (left) 0.6 2.3 9.0 0.8 -3.0 0.5 1.3 0.5
Average weekly red wine intake 2.7 4.0 5.6 2.0 2.1 1.8 1.6 2.4
Handedness (chirality/laterality): Left-handed 0.2 0.3 1.3 -0.4 1.1 -0.1 -0.1 0.1
Mood swings 0.7 1.3 3.3 0.3 -1.8 0.2 1.0 1.4
Loneliness, isolation 1.7 2.3 9.7 -0.1 -3.1 0.1 0.9 1.1
Long-standing illness, disability or infirmity 0.9 1.4 2.4 -1.2 -0.1 -1.3 -1.2 -1.6
Ever had bowel cancer screening 0.6 0.7 1.2 0.6 0.6 0.8 1.1 1.0
Diabetes diagnosed by doctor 0.3 0.5 1.1 -0.7 -1.1 -0.6 -0.5 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.6 -0.1 0.2 -0.4 -0.8 -0.7
Friendships satisfaction 0.7 0.9 3.1 -1.8 -0.5 -1.0 -0.3 -0.1
Qualifications: nursing, teaching 2.0 3.2 7.0 1.4 0.3 1.8 2.6 1.9
Commuting to job workplace: Walk 0.1 0.1 0.2 0.3 0.5 0.2 -0.2 0.3
Eye problems/disorders: Cataract 1.1 1.2 3.8 1.0 -1.9 0.8 0.7 0.5
Mouth/teeth dental problems: Mouth ulcers 0.9 1.4 3.4 -1.8 -0.1 -1.4 -1.1 -0.7
Medication for cholesterol 0.5 0.7 1.3 0.9 -0.7 1.1 0.6 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.0 0.0 -1.4 -0.5 -0.8 -1.3
Back pain experienced in last month 0.1 0.2 0.5 -0.7 -0.2 -0.5 0.0 -0.1
Mineral and other dietary supplements 0.6 0.9 3.6 0.0 -1.9 -0.3 0.6 0.5
Breast cancer (self-reported) 0.2 0.3 0.8 0.4 -0.9 0.2 -0.1 -0.5
Asthma (self-reported) 0.7 1.4 1.7 -1.3 0.9 -1.2 -1.2 -1.1
Osteoporosis (self-reported) 0.4 0.5 1.0 1.0 -0.8 0.7 0.6 -0.0
Osteoarthritis (self-reported) 0.4 0.5 0.8 -0.6 -0.9 -0.7 -0.7 -0.6
Medication: Aspirin 0.5 0.7 1.5 0.1 0.5 0.6 1.2 1.1
Medication: Gliclazide 0.6 0.6 1.0 0.8 1.0 0.8 0.6 0.6
Illnesses of father: None of the above (group 1) 0.9 1.1 1.8 -0.8 0.3 -1.4 -1.3 -1.2
Smoking status: Current 0.6 1.0 1.8 1.3 -1.1 1.3 0.5 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.3 1.1 0.1 -1.1 -0.3 -0.0 0.2
Whole body water mass 1.0 5.8 27.2 -0.6 -5.2 -0.8 -0.3 -0.8
Leg predicted mass (right) 1.0 5.5 27.0 -0.2 -5.2 -0.3 -0.2 -0.5
Arm fat mass (left) 1.0 4.0 18.3 0.5 -4.3 0.2 1.1 0.2
Number of self-reported non-cancer illnesses 0.8 1.4 2.8 1.0 -1.7 0.9 1.3 0.8
Average weekly champagne plus white wine intake 1.1 1.5 3.1 1.3 -1.8 1.1 0.8 0.8
Miserableness 1.4 2.4 5.8 -2.4 -1.0 -2.1 -0.7 -0.6
Guilty feelings 2.4 3.6 5.2 1.0 -2.1 1.6 2.2 2.3
Wears glasses or contact lenses 0.1 0.1 0.2 0.0 0.1 0.4 0.4 0.4
Ever taken oral contraceptive pill 0.4 0.4 1.5 -0.6 -1.2 -0.2 0.2 0.2
Hearing aid user 0.6 0.7 2.6 -0.2 1.6 -0.2 -0.6 -0.7
Mother’s age at death 4.6 5.8 7.4 2.2 1.8 2.7 2.7 2.5
Financial situation satisfaction 1.5 1.9 3.4 -1.6 -1.9 -1.5 -0.7 -0.8
Tinnitus: Yes, now most or all of the time 1.1 1.3 4.7 0.3 2.2 0.0 -0.9 -1.1
Commuting to job workplace: Public transport 0.7 0.8 1.6 1.2 0.7 1.3 0.6 0.7
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.1 -0.1 0.1 -0.4 -0.5
Medication: Blood pressure 0.8 1.6 2.4 -1.3 -0.4 -1.6 -1.2 -1.4
Pain type(s) experienced in last month: Hip pain 1.6 2.0 4.7 -2.2 0.0 -1.6 -1.3 -0.9
Supplements: Fish oil (including cod liver oil) 0.9 1.1 4.4 0.3 2.1 0.2 -0.8 -0.7
High cholesterol (Self-reported) 0.1 0.2 0.6 -0.2 -0.8 -0.3 0.5 -0.2
Medication: Bendroflumethiazide 0.5 0.8 1.7 0.1 -1.3 0.2 1.1 1.0
Medication: Paracetamol 0.3 0.4 1.1 -0.5 1.0 -0.7 -0.4 -0.3
Medication: Lisinopril 0.2 0.3 0.6 0.5 -0.8 0.4 0.7 0.4
Medication: Atorvastatin 1.3 1.6 2.3 -1.1 -0.8 -1.3 -1.5 -1.4
Illnesses of father: High blood pressure 0.4 0.5 1.3 0.2 -0.7 1.1 0.5 0.7
Alcohol drinker status: Never 0.2 0.3 1.1 -0.0 -1.0 -0.5 0.1 0.1
Ever smoked 0.6 1.0 4.6 -0.4 2.1 -0.2 -0.6 -0.3
Basal metabolic rate 1.0 5.5 26.3 -0.5 -5.1 -0.7 -0.2 -0.7
Leg fat percentage (left) 0.4 1.6 3.6 0.8 -1.9 0.5 1.6 0.8
Arm fat-free mass (left) 1.1 5.6 27.1 -0.4 -5.2 -0.7 0.1 -0.5
Number of operations (self-reported) 0.4 0.5 1.1 0.1 -0.4 0.6 1.0 1.1
Average weekly beer plus cider intake 1.1 1.5 2.6 -1.1 -1.0 -1.1 -1.6 -1.3
Irritability 1.2 2.0 4.5 0.8 -0.6 1.4 1.7 2.1
Risk taking 0.1 0.1 0.4 0.1 -0.7 -0.1 -0.0 -0.0
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.5 0.2 1.2 -0.2 -0.8 -0.8
Fractured/broken bones in last 5 years 2.7 3.4 5.3 2.3 -0.8 2.0 2.0 1.8
Age started oral contraceptive pill 1.0 1.3 2.0 1.1 -0.6 1.3 1.4 1.1
Diastolic blood pressure, automated reading 0.3 1.1 1.9 1.4 -0.7 1.3 0.9 0.7
Ever depressed for a whole week 0.1 0.1 0.2 -0.4 0.1 -0.2 0.0 0.3
Unable to work because of sickness or disability 1.0 1.3 2.7 -1.7 0.0 -1.4 -0.7 -1.2
Commuting to job workplace: Cycle 0.2 0.2 0.5 0.2 0.2 0.7 0.1 0.6
Myopia 0.9 1.3 3.1 1.6 0.9 1.8 0.2 0.3
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.1 0.8 1.0 1.0 0.8 1.0
Cholesterol lowering medication 0.1 0.2 0.4 0.5 0.6 0.2 0.3 0.0
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 3.6 1.1 0.6 1.3 1.9 1.8
Pain experienced in last month 2.2 3.6 5.5 2.2 2.0 2.4 1.2 1.5
Supplements: Calcium 0.6 0.6 0.7 0.7 0.8 0.8 0.8 0.7
Basal cell carcinoma (self-reported) 0.3 0.4 0.7 -0.2 0.8 -0.4 -0.7 -0.7
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.3 0.4 -0.3 0.4 0.6 0.5
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 0.7 -0.9 -0.7 -0.7 -0.7 -0.7
Heart disease (siblings) 0.2 0.2 0.9 0.5 -1.0 0.1 -0.1 0.1
Alcohol drinker status: Previous 1.7 1.9 3.4 1.1 -0.9 1.5 1.9 1.3
Pack years of smoking 0.7 1.1 3.5 0.4 -1.9 0.2 0.7 1.1
Impedance of whole body 0.8 4.1 12.1 2.0 3.5 1.6 0.7 1.3
Leg fat mass (left) 0.7 2.8 11.3 0.7 -3.4 0.3 1.4 0.6
Arm predicted mass (left) 0.9 4.6 22.2 -0.4 -4.7 -0.7 0.1 -0.5