Hub : Genes

MRVI1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2270 0.0460 1.3e-08 0.146 0.096 0.152 0.152 0.143 2.1e-17 8.8e-12 4.5e-18 4.4e-18 4.4e-17
2 METSIM Adipose 0.0534 0.0197 2.1e-03 0.008 0.019 0.008 0.022 0.009 1.8e-02 6.5e-04 2.0e-02 2.5e-04 1.5e-02
3 NTR Blood 0.0686 0.0171 2.4e-07 0.001 0.026 0.025 0.023 0.022 2.0e-01 7.5e-09 1.4e-08 4.9e-08 9.1e-08
4 ROSMAP Brain Pre-frontal Cortex 0.3676 0.0417 0.0e+00 0.295 0.219 0.298 0.298 0.305 2.4e-38 1.1e-27 9.1e-39 8.1e-39 9.4e-40
5 YFS Blood 0.4907 0.0305 0.0e+00 0.476 0.558 0.587 0.532 0.578 2.5e-179 9.8e-226 8.6e-245 3.4e-210 8.1e-239
6 TCGA Breast Invasive Carcinoma 0.0445 0.0176 5.2e-05 0.022 0.022 0.010 NA 0.015 1.7e-05 2.3e-05 2.5e-03 NA 3.3e-04
7 TCGA Kidney Renal Papillary Cell Carcinoma 0.1500 0.0590 2.6e-03 0.011 0.030 0.057 NA 0.024 7.4e-02 8.0e-03 3.5e-04 NA 1.6e-02
8 TCGA Brain Lower Grade Glioma 0.0714 0.0286 7.9e-04 0.009 0.030 0.024 NA 0.023 2.8e-02 2.1e-04 7.8e-04 NA 1.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 1.0 1.6 7.0 0.1 1.4 -0.1 0.6 2.6 -1.5 1.1 0.3
Bipolar Disorder or Schizophrenia 0.3 0.8 3.4 -0.3 0.7 -1.0 -0.0 1.8 -1.2 0.2 0.3
Depressed Affect (Nagel 2018) 0.6 1.2 3.9 -1.0 0.8 2.0 -0.9 -0.4 0.6 -0.7 -1.3
Depression (Nagel 2018) 0.7 1.1 4.4 -0.1 1.1 2.1 -0.0 1.3 0.4 -1.0 -0.5
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.7 1.3 -0.3 -0.6 1.2 -1.1 -0.4 0.6 0.8
Neuroticism (Nagel 2018) 0.8 2.0 3.1 -1.6 0.1 1.5 -1.4 -1.0 -1.2 -1.8 -1.8
Schizophrenia (2018) 0.2 0.3 1.4 -0.5 -0.2 -1.2 -0.5 0.3 -0.4 -0.7 0.1
Schizophrenia vs Biploar Disorder 0.7 0.9 1.3 1.1 -1.2 -0.7 0.8 -1.1 1.1 0.8 0.9
Worry (Nagel 2018) 0.6 1.4 4.9 -0.7 -1.1 -0.2 -0.6 -1.1 -1.3 -2.2 -1.0
Alzheimer’s Disease (in mother) 1.4 1.6 3.0 1.3 1.3 0.9 1.7 0.5 1.7 0.2 1.7
Alzheimer’s Disease (in father) 0.7 0.8 2.0 0.7 0.9 0.6 1.0 -0.5 1.4 0.9 -0.6
Alzheimer’s Disease (including proxy) 1.1 1.5 5.4 0.8 1.6 1.3 1.3 -0.0 2.3 0.3 -0.0
Crohns Disease (2017) 1.5 3.4 7.6 -2.0 0.5 1.2 -2.6 -0.1 -2.1 -1.4 -2.8
Irritable Bowel Disease (IBD) 1.7 4.1 10.2 -2.2 1.0 1.5 -2.9 -0.9 -2.2 -0.8 -3.2
Ulcerative Colitis (UC) 1.0 1.9 3.9 -1.3 1.1 1.3 -1.8 -1.0 -1.7 -0.4 -2.0
Major Depression (MDD) 1.3 1.6 4.8 -1.6 1.1 1.2 -2.2 0.2 -0.1 0.0 -1.7
Reaction Time 0.5 1.0 3.6 -0.6 1.9 -0.1 -0.4 -0.6 1.2 -0.6 -1.4
Verbal and Numeric Reasoning (VNR) 0.9 2.1 6.2 -0.7 1.8 1.4 -0.2 0.4 -2.2 -2.5 -0.3
Breast Cancer 0.6 1.4 6.1 0.3 -1.0 -0.2 0.5 -2.5 0.1 0.4 1.9
Ovarian Cancer 1.1 1.5 4.6 2.1 -0.7 -0.7 1.9 0.1 0.6 0.7 1.5
Prostate Cancer 0.4 0.6 2.9 0.4 0.4 0.0 1.0 0.0 -0.2 -0.9 1.7
Age at First Birth 0.2 0.3 0.9 0.5 -0.3 -0.1 0.9 0.5 -0.9 0.4 0.3
Bipolar Disorder (2011) 1.5 1.5 4.9 -1.4 1.1 0.1 -1.3 1.1 -2.2 -0.5 -0.7
Body Mass Index (BMI) (2010) 0.3 0.4 2.0 0.3 -0.6 0.1 0.5 1.4 0.5 0.0 0.6
Coronary Artery Disease (CAD) 0.5 0.7 2.0 -0.9 -1.4 -0.2 -0.9 0.6 0.3 -0.9 0.4
Crohns Disease (2012) 2.0 3.3 8.8 -2.1 0.4 1.1 -2.6 -0.2 -1.5 -1.7 -3.0
Mean Putamen Volume 1.4 1.6 5.1 -1.4 1.3 -1.1 -0.8 0.8 -2.2 -1.1 -0.5
Fasting Glucose 1.0 1.2 2.8 -1.6 0.9 -0.0 -1.7 0.9 -0.4 -1.0 -1.1
HbA1C 0.3 0.4 1.1 -0.6 -1.1 0.1 -0.2 -0.6 0.9 0.2 -0.4
HDL Cholesterol 0.4 0.7 2.0 -0.3 -1.0 1.4 -0.6 1.1 -1.0 0.1 -0.0
LDL Cholesterol 0.6 1.0 3.1 0.9 -0.9 1.8 0.1 -0.9 -0.0 0.8 1.1
Lupus 0.4 0.6 2.2 0.2 1.1 0.6 -0.3 1.5 -0.8 -0.3 -0.7
Neuroticism (2016) 2.8 4.0 10.8 -2.4 -0.8 1.1 -2.9 -0.4 -0.8 -2.1 -3.3
Primary Biliary Cirrhosis 1.4 2.0 5.1 -2.3 0.7 0.7 -1.5 1.2 -1.9 -1.5 -0.7
Rheumatoid Arthritis 0.8 1.1 3.3 -0.1 1.5 0.8 -0.9 -0.0 -1.1 -1.8 -0.3
Schizophrenia (2014) 0.3 0.6 2.1 -0.3 0.3 -1.4 0.3 1.2 0.1 0.3 1.0
Triglycerides 0.8 1.3 4.0 1.1 1.5 -0.4 1.0 -0.6 2.0 0.7 0.8
Type 2 Diabetes (T2D) (2012) 0.9 1.0 3.2 1.8 1.4 1.1 0.7 0.1 -0.8 -0.4 0.4
Ulcerative Colitis 2.3 3.4 8.8 -2.5 0.2 0.2 -2.5 -1.7 -1.6 -0.4 -3.0
Blood Eosinophil Count 0.3 2.3 3.7 -1.6 1.4 -0.2 -1.6 1.9 -1.0 -1.7 -1.9
Blood Platelet Count 0.4 4.6 19.3 0.8 2.5 4.4 0.6 0.9 1.7 -0.5 2.5
Blood Red Count 0.8 7.7 13.5 2.8 1.9 3.1 3.1 1.4 3.5 2.0 3.7
Blood White Count 0.1 0.8 2.8 -0.3 1.7 -0.6 -0.3 -1.2 -0.4 0.9 -0.6
Heel T-Score 0.1 0.7 2.7 -0.0 -0.1 1.0 0.7 -0.8 -1.6 -0.6 -0.8
BMI 0.3 1.6 6.2 0.7 0.2 0.3 0.8 -2.5 1.5 1.5 -1.0
Height 0.1 2.4 7.8 -1.3 1.7 2.8 -1.7 1.2 -1.1 -0.3 -1.1
Waist Hip Ratio (WHR) 1.3 5.8 22.3 -2.3 -0.9 4.7 -2.1 2.1 -0.8 -2.8 -0.5
Systolic Blood Pressure 1.9 9.6 29.3 2.9 -2.3 -5.4 3.4 -4.4 -0.8 0.3 1.5
Smoking Status 0.6 1.5 5.2 0.8 1.9 1.5 0.6 2.3 -0.3 -0.0 0.5
Allergy or Eczema 2.9 7.5 17.0 -4.1 0.3 0.9 -3.8 0.6 -3.6 -2.0 -3.2
Cardiovascular Disease 1.1 3.8 8.6 2.1 0.1 -1.5 2.4 -2.9 1.7 1.6 1.8
Hypothyroidism (self reported) 1.0 2.4 6.8 1.7 -0.2 -1.3 2.6 1.4 1.1 0.2 2.0
Respiratory disease 1.2 2.7 5.7 -1.6 -1.9 -1.4 -1.3 -2.2 -2.4 -0.9 -0.9
Type 2 Diabetes (T2D) (2018) 1.2 2.3 5.2 0.8 0.9 1.2 1.2 -1.8 2.0 1.3 2.3
Lung FEV1/FVC ratio 1.5 7.6 21.3 -2.0 2.0 4.6 -2.9 4.2 -0.7 -1.4 -1.5
Lung FVC 0.8 4.2 9.3 2.3 0.7 1.1 2.6 2.8 1.2 1.0 3.0
Neuroticism 0.4 1.0 2.9 -1.2 -0.7 0.3 -1.0 -1.4 -0.2 -1.7 -0.5
Chronotype (morning person) 1.0 2.2 4.5 -1.5 0.4 1.5 -2.1 -0.6 1.1 -2.0 -1.7
Hair Pigment 0.0 0.8 2.8 0.6 1.4 1.7 0.0 0.8 0.8 0.4 0.3
Tanning 0.2 2.0 10.6 -0.2 -3.2 -1.4 -0.4 -1.0 1.1 0.9 0.8
Hand grip strength (left) 0.1 0.3 1.1 0.5 1.1 0.3 0.3 -0.2 0.5 0.5 0.9
Number of treatments/medications taken 1.8 3.3 8.7 2.3 -0.8 0.6 2.9 -0.8 1.9 0.3 2.6
Average weekly spirits intake 0.9 1.1 3.9 0.3 0.2 -0.9 -0.0 -0.7 -2.0 -1.8 -0.1
Sensitivity / hurt feelings 0.5 0.8 1.7 -0.8 -1.3 1.1 -1.3 -0.2 -0.2 0.0 -1.3
Frequency of depressed mood in last 2 weeks 0.8 1.2 4.7 -0.5 1.4 2.2 -0.6 0.6 0.4 -0.7 -1.0
Hearing difficulty/problems: Yes 1.0 1.6 3.1 1.7 0.3 0.2 1.7 -1.8 0.6 0.3 1.7
Relative age of first facial hair 0.2 0.4 2.2 -0.1 0.4 0.0 -0.6 0.0 -1.5 -0.8 -0.2
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 3.5 -1.9 -0.3 1.0 -1.1 -0.9 -1.3 0.3 -1.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.3 0.4 -0.9 1.5 0.5 -0.4 0.5 -0.4 1.5
Ever had hysterectomy (womb removed) 1.1 1.2 5.5 -0.1 0.0 2.4 0.4 0.4 0.5 -1.0 1.6
Systolic blood pressure, automated reading 1.4 4.0 10.8 1.0 -3.3 -3.0 1.4 -2.6 -1.1 -0.8 -0.7
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 4.5 -1.2 0.2 0.9 -1.3 -0.8 -2.1 -1.4 -0.3
Angina 0.3 0.4 1.0 -0.2 -0.4 -1.0 -0.1 0.5 -1.0 -0.6 0.1
Medication for hormone replacement therapy 0.7 0.8 3.2 1.1 -0.2 1.1 0.5 0.3 -0.3 0.2 1.8
Vitamin and mineral supplements 0.7 1.0 2.7 0.8 0.7 -0.8 1.2 -0.7 1.1 -1.6 0.6
Supplements: Zinc 2.7 2.9 7.4 1.5 -1.4 -2.2 1.8 0.2 0.9 2.7 1.8
Medication: Co-codamol 1.3 1.5 3.8 -1.9 -0.1 0.9 -1.9 1.2 0.7 0.1 -1.4
Medication: Metformin 1.1 1.6 4.7 0.5 0.6 0.7 1.0 -1.9 1.0 1.0 2.2
Diabetes (father) 1.0 1.2 3.5 1.0 1.0 1.7 1.0 1.9 0.6 0.4 0.0
Diabetes (mother) 0.5 0.6 2.5 -0.6 -1.6 -1.3 -0.0 -0.1 -0.2 -0.4 -0.0
Severe depression (siblings) 0.9 1.0 2.4 1.6 -0.4 0.6 1.3 -0.3 -1.4 -0.9 0.7
Pack years adult smoking proportion 0.5 0.8 5.2 0.0 1.0 -0.2 0.4 0.2 -0.2 -2.3 0.2
Impedance of leg (right) 0.3 1.6 5.8 0.3 -0.1 2.0 0.0 2.4 0.4 -1.0 1.3
Leg fat-free mass (left) 0.3 1.6 5.1 -1.0 0.7 -0.2 -1.1 -2.3 -1.0 0.2 -1.9
Trunk fat percentage 0.2 1.0 2.3 -0.4 -1.0 0.9 -0.2 -1.0 0.6 -1.5 -1.4
Hand grip strength (right) 0.2 0.6 1.9 -0.6 0.7 1.4 -1.1 -0.3 -0.4 0.5 0.4
Townsend deprivation index at recruitment 0.2 0.4 1.0 -0.8 -0.7 0.3 -1.0 0.5 -0.4 0.3 -0.4
Current tobacco smoking 0.8 1.3 4.3 0.5 1.1 1.9 -0.2 2.1 0.8 -0.0 -0.9
Average weekly fortified wine intake 0.3 0.4 0.8 0.6 -0.7 -0.8 0.5 0.2 0.4 0.9 0.5
Maternal smoking around birth 0.2 0.2 0.5 -0.3 -0.3 0.7 0.5 0.1 0.7 -0.7 0.1
Fed-up feelings 0.5 1.0 2.5 0.6 1.2 1.6 0.9 0.5 0.7 -1.2 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.9 -0.4 -0.4 1.7 -0.5 1.1 0.5 -0.2 -0.7
Relative age voice broke 0.3 0.4 1.8 0.2 0.6 -0.1 -0.6 1.3 -0.6 -0.2 -0.5
Taking other prescription medications 0.5 0.7 3.8 -0.2 -0.1 0.8 0.3 -0.9 -0.5 -2.0 -0.2
Age when periods started (menarche) 1.1 2.6 7.5 -1.1 -2.3 -2.7 -1.3 -2.2 -0.4 -0.1 -0.6
Bilateral oophorectomy (both ovaries removed) 1.1 1.3 3.2 -0.2 -1.8 1.6 -0.1 -1.0 1.5 0.7 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 4.9 2.1 0.9 0.2 2.2 0.4 -1.0 -1.3 0.7
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.7 -1.3 1.9 -0.3 -1.6 0.8 -0.9 -1.0 -1.6
Qualifications: CSEs or equivalent 1.8 2.3 5.9 -1.9 1.6 1.8 -1.7 0.3 -0.4 -2.4 -0.4
Serious illness, injury or assault to yourself 1.1 1.3 2.9 1.7 0.1 -0.1 1.5 -1.3 1.0 0.0 1.6
High blood pressure 1.3 3.5 6.3 2.0 -2.2 -0.9 2.5 -2.3 1.1 1.5 1.8
Hayfever, allergic rhinitis or eczema 2.3 4.9 11.3 -3.4 0.9 0.1 -3.0 0.7 -3.0 -1.6 -2.5
Multivitamins +/- minerals 1.2 1.5 3.5 -1.7 0.7 1.2 -1.9 0.2 -1.2 1.1 -0.9
Stomach or abdominal pain in last month 1.4 1.8 6.9 -1.3 -0.4 -0.3 -1.7 -0.8 -2.6 -0.1 -1.4
Supplements: Glucosamine 1.0 1.3 4.9 0.5 -1.2 1.9 0.3 -0.2 -0.2 2.2 0.5
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 4.4 -1.6 0.4 2.0 -1.8 2.1 0.3 -1.0 -1.6
Medication: Atenolol 1.2 1.5 4.0 1.9 -1.0 -1.2 2.0 0.2 -0.2 0.8 1.2
Medication: Levothyroxine sodium 1.1 1.8 5.7 1.7 0.0 -0.7 2.4 0.7 1.5 0.4 1.5
Sitting height 0.1 0.8 1.9 0.8 1.1 0.1 0.6 -0.9 -1.4 0.6 1.0
Chronic bronchitis/emphysema (father) 0.6 0.8 3.4 0.7 0.3 0.5 0.4 -1.9 0.1 1.2 0.4
High blood pressure (mother) 1.8 2.6 9.9 1.3 -1.1 -3.1 1.7 -1.0 -0.2 2.0 0.7
Body mass index (BMI) 0.2 0.9 4.6 0.4 -0.6 0.3 0.5 -2.1 0.8 -0.2 -0.9
Impedance of leg (left) 0.6 2.8 9.8 0.8 0.0 2.6 0.6 3.1 0.7 -1.1 1.9
Leg predicted mass (left) 0.3 1.7 5.1 -1.1 0.7 -0.1 -1.2 -2.3 -1.1 0.2 -1.9
Trunk fat mass 0.2 0.8 2.4 -0.4 -0.7 0.9 -0.2 -1.5 0.2 -1.1 -1.3
Waist circumference 0.2 0.9 3.6 -0.2 -0.6 1.7 0.1 -1.9 0.3 -0.5 -0.1
Number of incorrect matches in round 1.6 2.6 4.8 1.7 -1.7 -2.2 2.0 -0.5 0.0 1.5 2.0
Past tobacco smoking 0.9 1.7 6.4 0.1 -2.5 -2.0 0.0 -0.2 1.3 -1.1 -0.5
Alcohol usually taken with meals 1.4 2.3 6.3 1.1 -1.7 -1.9 0.8 -1.7 -0.6 2.5 0.5
Nervous feelings 1.2 2.2 8.0 -1.5 -0.7 -0.2 -1.5 0.3 -1.3 -2.8 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 3.3 0.6 0.1 0.9 0.1 -0.6 1.8 0.4 0.1
Hearing difficulty/problems with background noise 5.1 8.2 14.8 3.5 0.1 -1.1 3.9 -3.4 3.0 2.3 3.5
Hair/balding pattern: Pattern 2 0.6 0.7 1.3 0.8 1.1 -0.8 0.9 0.6 -0.9 -1.1 -0.0
Had menopause 0.7 0.9 2.2 0.7 -1.4 0.8 0.7 -0.3 1.1 0.3 1.5
Had other major operations 0.4 0.5 1.2 0.0 -0.8 0.9 0.4 1.1 0.1 -1.0 0.3
Forced vital capacity (FVC) 0.6 2.4 11.0 0.0 2.3 1.6 0.3 3.3 -0.2 -0.1 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 4.3 2.1 1.3 0.4 2.1 0.8 -1.1 -0.9 0.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 2.3 0.1 0.2 -0.1 -0.1 0.2 1.5 1.2 -0.5
Qualifications: None of the above 0.1 0.3 1.0 -0.6 -1.0 -0.0 -0.4 -0.2 0.8 -0.6 0.0
Financial difficulties in last 2 years 0.1 0.1 0.6 -0.1 -0.1 0.1 0.1 0.2 0.8 0.3 -0.2
Mouth/teeth dental problems 1.2 1.9 5.4 1.1 -0.3 -2.3 1.8 0.5 -1.3 0.7 1.6
Heart attack 0.6 0.7 2.2 -1.4 0.1 -0.2 -1.5 -0.6 -0.8 0.3 -0.8
Allergy 1.8 4.0 10.4 3.2 0.2 0.6 2.7 -0.1 2.2 2.0 2.3
Pain all over the body in last month 3.2 3.5 8.2 2.8 1.4 1.1 2.8 0.6 0.6 -0.3 2.9
Diabetes (self-reported) 1.3 2.1 7.5 0.4 -0.9 1.0 1.0 -2.7 1.8 1.2 1.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.4 -0.4 -1.1 -1.2 -0.6 0.4 -1.2 -0.4 -0.3
Medication: Ramipril 0.4 0.6 1.2 0.9 0.6 0.3 0.5 -0.9 -0.9 0.4 1.1
Medication: Simvastatin 0.5 0.7 2.5 0.9 -0.6 -0.7 0.5 -1.6 0.7 1.1 0.3
Fluid intelligence score 0.9 2.0 7.0 -1.4 1.1 1.0 -1.1 0.1 -2.6 -1.0 -1.5
Illnesses of siblings 0.4 0.5 1.6 0.4 1.1 -0.3 0.2 1.3 0.5 -0.8 0.5
Neuroticism score 0.3 0.7 2.4 -0.6 -1.1 0.6 -0.6 -0.5 -0.1 -1.5 -0.9
Weight 0.2 0.8 4.0 -0.2 0.1 1.0 -0.2 -2.0 -0.0 -0.0 -1.1
Impedance of arm (right) 0.3 1.3 4.1 -1.0 -0.3 -1.0 -0.5 2.0 -0.1 -2.0 -0.2
Arm fat percentage (right) 0.2 0.9 2.0 -0.4 -1.0 0.1 -0.1 -1.4 0.3 -1.4 -1.4
Trunk fat-free mass 0.1 0.8 3.0 -0.4 0.6 0.5 -0.9 -1.7 -1.0 0.7 -0.9
Hip circumference 0.3 1.4 8.5 0.7 0.7 -0.5 0.7 -2.9 0.4 0.3 -0.7
Time employed in main current job 1.3 1.5 5.9 -0.7 0.5 2.4 -0.8 0.4 -1.1 -1.8 0.1
Alcohol intake versus 10 years previously 0.4 0.5 1.0 -0.3 -0.7 0.8 -0.4 0.9 -0.8 0.7 1.0
Father’s age at death 1.3 1.7 3.3 -0.8 0.6 -1.1 -1.0 1.2 -1.7 -1.8 -1.6
Worrier / anxious feelings 0.5 0.9 3.6 -0.5 -0.1 0.8 -0.5 -0.6 -0.4 -1.5 -1.9
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.7 3.4 1.0 1.5 1.8 1.2 0.9 1.7 -0.3 1.2
Falls in the last year 0.9 1.2 5.8 -0.4 1.1 2.4 0.1 1.4 0.1 -0.5 0.4
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 -0.5 -0.2 -0.4 -0.7 -1.0 -1.1 1.2 -0.6
Number of live births 0.9 1.2 3.1 1.7 -0.5 -0.1 1.8 -0.3 1.1 0.8 1.4
Forced expiratory volume in 1-second (FEV1) 1.1 3.7 17.3 0.5 2.2 2.5 0.2 4.2 0.1 -0.1 0.5
Pulse rate 0.5 0.8 3.0 -0.1 -0.4 0.9 -0.1 0.6 1.7 -1.5 -0.0
Happiness 0.4 0.5 2.5 -0.4 0.3 -0.6 -0.7 -0.3 0.3 -0.6 -1.6
Noisy workplace 1.4 1.7 4.0 -0.8 -0.3 1.4 -1.4 -0.7 -1.9 -2.0 -0.8
Qualifications: A levels/AS levels or equivalent 0.5 1.1 2.2 1.4 1.3 -0.2 1.5 0.5 -0.9 1.3 0.5
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 2.8 -0.6 0.6 1.2 -0.9 0.7 -1.7 -1.5 -1.1
Mouth/teeth dental problems: Dentures 1.0 1.7 7.0 -0.5 1.9 2.6 -0.8 0.1 -0.0 -1.1 -0.9
Asthma 0.9 1.7 5.2 -1.1 -1.4 -1.6 -0.5 -1.6 -2.3 -0.3 -0.5
Medication: Ibuprofen (e.g. Nurofen) 1.9 2.4 6.9 1.0 0.0 0.9 1.2 2.2 2.6 0.6 2.1
Medication: Cholesterol lowering 0.9 1.5 8.3 0.0 -0.1 -0.1 0.2 -2.9 0.5 1.7 0.5
Depression (self-reported) 0.9 1.1 2.2 -1.1 0.2 0.1 -1.4 -1.5 -1.2 -0.9 -1.1
Medication: Lansoprazole 0.6 0.7 2.9 -0.4 -0.9 1.1 -0.4 -0.0 0.2 -1.7 -0.5
Prospective memory result 0.5 0.6 1.1 -1.0 -0.5 -0.7 -1.0 -0.6 0.9 -1.0 -0.3
Lung cancer (father) 0.2 0.2 0.6 -0.1 -0.2 0.3 -0.3 0.4 -0.8 0.0 -0.7
Illnesses of mother 0.8 1.0 2.7 1.1 0.9 1.6 0.3 0.8 0.4 -1.5 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.8 15.9 -0.3 2.5 2.6 -0.6 4.0 0.1 -1.2 0.3
Pulse wave Arterial Stiffness index 0.4 0.5 1.5 -0.1 -0.1 0.8 0.6 0.6 1.2 -0.4 0.9
Impedance of arm (left) 0.2 0.9 2.4 -0.7 -0.6 -1.3 -0.2 1.5 0.2 -1.6 0.0
Arm fat mass (right) 0.2 1.0 3.0 -0.8 -0.7 0.5 -0.7 -1.7 0.4 -0.7 -1.6
Trunk predicted mass 0.1 0.8 2.9 -0.4 0.6 0.5 -0.8 -1.7 -0.9 0.7 -0.8
Standing height 0.1 1.4 2.8 -1.1 1.5 1.7 -1.3 0.5 -1.6 0.3 -0.4
Length of working week for main job 0.8 0.8 3.3 -0.4 -0.9 0.7 -0.7 0.2 -1.2 -1.8 0.3
Exposure to tobacco smoke at home 0.4 0.4 1.3 -0.2 -0.7 -0.7 0.2 -0.9 -0.4 0.2 1.1
Breastfed as a baby 1.2 1.5 4.4 1.3 0.6 -1.2 1.8 2.1 -0.7 0.6 0.3
Tense / ‘highly strung’ 0.6 0.9 2.1 -1.5 -0.9 0.5 -1.3 -1.1 0.5 -0.6 -0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 2.0 1.1 -0.8 1.4 0.5 -1.3 -0.3 1.3 0.2
Hair/balding pattern: Pattern 4 0.1 0.3 1.7 -0.4 -0.2 -0.3 0.0 1.3 0.4 -0.5 0.2
Birth weight of first child 0.6 1.1 3.0 0.7 0.2 -0.1 0.1 1.5 -1.7 -1.5 -0.8
Peak expiratory flow (PEF) 1.9 4.5 24.6 0.7 1.7 2.6 0.2 5.0 -1.0 -0.5 0.2
Pulse wave reflection index 1.3 1.6 3.8 1.2 1.2 1.6 2.0 1.4 -0.0 0.2 1.3
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.9 -0.8 -0.1 -0.5 -0.7 0.1 0.4 -1.1 -1.7
Loud music exposure frequency 0.8 0.9 2.7 -0.9 0.4 -1.1 -0.7 -0.4 1.1 0.4 -1.6
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 2.9 0.0 -0.5 0.7 -0.1 1.7 -0.1 0.8 -0.3
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.6 -0.3 -0.8 0.4 -0.5 0.3 0.4 -0.4 -0.6
Blood clot in the leg (DVT) 0.7 0.9 2.6 -0.0 1.6 -0.8 -0.1 0.7 0.6 -0.6 -1.5
Medication: Paracetamol 3.0 4.9 13.6 2.1 0.3 -0.2 3.0 1.5 3.7 1.9 2.5
Headache pain in last month 1.8 3.1 10.0 1.1 1.1 2.1 0.8 -0.2 3.2 0.7 2.5
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 4.3 -0.3 -0.0 -0.4 -0.5 2.1 -0.2 -1.4 -0.2
Glaucoma (self-reported) 1.1 1.3 2.6 0.4 1.2 -1.4 1.6 0.9 -0.9 1.5 0.1
Gout (self-reported) 1.8 2.4 5.9 2.3 0.3 -0.9 2.1 -0.9 2.4 -0.1 1.4
Hypothyroidism/myxoedema (self-reported) 0.9 1.7 5.1 1.5 -0.4 -1.0 2.3 0.9 1.3 0.2 1.7
Medication: Amlodipine 1.2 1.7 3.4 -1.9 -1.7 -0.9 -1.8 -0.6 -0.6 -0.0 -1.5
Medication: Ventolin 100micrograms inhaler 1.7 2.2 5.1 -0.9 -2.3 -1.9 -0.4 -2.2 -0.3 1.5 -0.7
Birth weight 1.0 2.1 9.5 0.8 -0.1 -2.1 0.4 -0.3 1.5 3.1 -0.1
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.3 0.4 -0.1 -0.8 1.0 -1.2 0.3 0.1 0.1
High blood pressure (siblings) 1.0 1.4 4.1 0.8 -1.4 -0.8 1.1 -2.0 -0.6 1.6 -0.3
Forced vital capacity (FVC), Best measure 0.6 2.2 9.2 -0.7 2.3 1.2 -0.5 3.0 -0.3 -0.6 0.3
Body fat percentage 0.2 1.0 2.2 -0.2 -1.2 1.1 -0.0 -1.0 0.5 -1.5 -1.3
Leg fat percentage (right) 0.2 0.8 2.0 0.6 -0.9 1.4 0.6 -1.0 0.6 -1.1 -0.6
Arm fat-free mass (right) 0.1 0.7 2.9 -0.2 0.5 1.1 -0.6 -1.7 -0.3 0.8 -0.6
Exposure to tobacco smoke outside home 0.3 0.3 1.1 -0.5 0.7 1.1 0.1 0.3 -0.6 -0.7 -0.1
Comparative body size at age 10 0.4 1.2 2.8 -0.2 1.7 0.7 -0.1 1.1 -0.4 -1.6 -1.5
Number of full brothers 0.7 0.8 2.2 0.1 -0.2 -1.3 0.7 -0.3 0.9 1.2 1.5
Worry too long after embarrassment 0.4 0.7 2.5 -0.9 0.5 0.7 -0.8 0.2 -0.4 -1.6 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.0 1.3 0.1 -0.7 1.4 -0.7 -0.2 -0.2 1.0
Wheeze or whistling in the chest in last year 0.8 1.5 3.3 -1.4 -0.5 -1.1 -0.9 -0.6 -1.4 -1.4 -1.8
Number of children fathered 2.9 3.3 7.7 0.9 -2.0 -0.8 1.8 -1.3 2.8 1.5 2.4
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.3 1.1 -0.5 -0.4 1.5 -0.3 0.4 -0.6 1.5
Age at first live birth 1.1 2.0 7.7 0.0 -0.4 -2.8 0.2 -1.0 -1.5 1.9 -1.1
Pulse wave peak to peak time 0.4 0.5 1.3 0.1 0.2 -0.8 -0.6 -0.6 -1.1 0.6 -1.0
Health satisfaction 1.4 1.8 5.3 -2.3 -0.7 -1.0 -1.4 -0.3 0.7 -2.2 -0.2
Shortness of breath walking on level ground 1.4 1.6 6.3 -0.1 -1.7 -1.1 1.0 -1.2 2.5 -0.3 0.4
Qualifications: College or University degree 0.4 1.1 4.5 0.2 2.1 -0.8 0.7 -0.1 -1.9 -0.0 0.2
Eye problems/disorders: None of the above 0.9 1.0 2.9 1.3 -0.7 -0.4 0.6 -0.1 1.7 1.4 0.8
Mouth/teeth dental problems: Loose teeth 0.4 0.5 2.5 0.5 0.2 0.9 -0.2 -1.6 -0.5 0.1 0.2
Emphysema/chronic bronchitis 0.7 0.8 1.6 -1.3 0.7 0.6 -1.2 1.2 -0.1 -0.7 -0.7
Medication for pain relief, constipation, heartburn 1.3 2.3 8.5 -1.1 -0.2 -0.6 -1.4 -1.5 -2.9 -0.5 -1.9
Neck or shoulder pain in last month 1.4 2.0 4.9 2.0 0.2 1.1 1.1 1.4 0.1 -2.2 1.6
Medication: Blood pressure 0.2 0.4 1.1 0.7 -0.4 -0.3 0.9 -1.1 -0.2 0.4 0.3
Angina (self-reported) 0.3 0.4 1.0 -0.0 -0.2 -0.9 0.2 0.6 -1.0 -0.8 0.2
Migraine (self-reported) 7.4 9.2 21.6 4.6 1.0 1.6 3.9 1.4 4.2 0.1 3.7
Medication: Ibuprofen 1.4 1.7 3.9 1.2 0.0 0.2 1.4 1.5 1.8 0.5 2.0
Medication: Allopurinol 1.2 1.7 3.3 1.5 0.6 -1.2 1.7 -1.4 1.8 0.2 1.0
Medication: Omeprazole 0.9 1.0 4.3 0.8 0.2 2.1 0.8 1.4 0.2 -0.8 0.1
Medication: Seretide 50 evohaler 0.4 0.4 1.4 -0.3 0.2 -1.0 0.7 -1.2 -0.1 0.5 0.3
Mean time to correctly identify matches 0.4 0.7 2.8 -0.3 0.5 -0.2 -0.0 -1.3 1.7 0.0 -0.8
Heart disease (mother) 0.6 0.7 1.3 -0.7 -0.2 0.7 -0.8 0.9 -1.0 -1.2 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.3 -0.8 0.7 1.1 -0.7 -0.8 -0.8 -0.5 -0.3
Whole body fat mass 0.2 0.9 1.9 -0.4 -0.5 1.2 -0.3 -1.4 -0.1 -1.1 -1.3
Leg fat mass (right) 0.2 0.8 2.5 0.2 -0.5 1.3 0.1 -1.6 0.3 -0.7 -1.1
Arm predicted mass (right) 0.1 0.7 2.4 -0.0 0.4 1.3 -0.5 -1.6 -0.2 0.7 -0.6
Pulse rate, automated reading 1.0 3.4 14.1 -1.5 0.7 3.8 -1.8 1.3 0.1 -2.1 -1.0
Alcohol intake frequency. 1.0 2.4 5.0 2.1 -0.5 0.2 2.2 1.2 1.7 0.9 2.1
Comparative height size at age 10 0.2 1.2 7.3 -0.5 0.7 2.7 -0.7 0.7 -0.5 0.4 0.2
Number of full sisters 5.7 7.0 14.5 3.5 -0.9 -0.3 3.8 -0.6 3.0 3.0 3.0
Suffer from ‘nerves’ 0.3 0.4 1.4 -0.3 -1.2 0.2 -0.5 -0.7 -0.5 -0.8 0.0
Overall health rating 0.9 2.0 4.5 -1.8 0.7 2.1 -1.6 -0.5 0.1 -1.7 -1.5
Chest pain or discomfort 1.0 1.5 7.8 -1.0 0.5 0.3 -0.6 -0.4 -2.8 -1.4 -0.5
Had major operations 1.0 1.2 4.8 -0.2 1.3 0.5 -0.3 2.2 -0.6 -0.5 -1.4
Age at last live birth 1.1 1.6 6.1 -0.9 -0.3 -2.5 -0.7 0.1 -1.7 0.3 -1.5
Family relationship satisfaction 0.7 0.8 2.8 0.6 -0.1 -1.7 0.7 -1.4 -0.9 -0.2 0.6
Leg pain on walking 0.3 0.4 1.4 0.1 -0.7 -0.7 0.5 0.2 1.2 -0.7 0.2
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.6 4.9 1.4 -0.3 0.3 1.5 0.6 2.2 1.1 1.3
Commuting to job workplace: Car/motor vehicle 1.5 1.7 3.6 1.7 -1.8 0.4 1.9 -0.5 0.7 0.9 1.7
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.1 0.3 -0.2 -0.9 0.7 -0.3 0.3 1.0 1.1
Medication: Aspirin 0.1 0.1 0.3 -0.1 0.2 0.3 -0.1 -0.5 -0.1 -0.3 0.3
Supplements: Vitamin C 1.3 1.6 6.0 0.7 -2.4 -1.3 0.1 -0.3 -0.4 1.9 0.4
Knee pain experienced in last month 0.9 1.4 4.9 -0.4 -2.2 -0.9 -0.9 -0.6 -0.0 -1.9 -0.5
Hypertension (Self-reported) 1.3 3.6 7.5 2.1 -1.9 -1.0 2.7 -2.1 1.1 1.6 2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.3 3.9 -0.8 -1.4 2.0 -1.1 -0.2 -0.7 -1.4 -0.6
Illnesses of father: Heart disease 0.7 1.0 5.4 -1.0 -0.5 2.3 -1.1 -0.1 0.2 -0.0 0.0
Illnesses of siblings: Diabetes 0.8 1.0 2.7 -0.5 -1.2 -0.5 -0.2 -0.6 1.4 1.6 -0.9
Smoking status: Previous 0.6 0.9 4.2 -0.3 2.0 0.9 -0.3 0.3 -1.2 0.3 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 3.7 -1.0 1.4 1.3 -1.5 1.2 -0.4 -0.1 -1.9
Whole body fat-free mass 0.2 1.1 3.6 -0.7 0.7 0.4 -1.0 -1.9 -0.9 0.5 -1.3
Leg fat-free mass (right) 0.2 1.1 3.7 -0.8 0.8 -0.0 -0.9 -1.9 -0.8 0.1 -1.6
Arm fat percentage (left) 0.2 0.9 2.3 -0.2 -1.0 -0.1 0.1 -1.5 0.6 -1.2 -1.4
Average weekly red wine intake 0.4 0.5 1.6 -0.7 0.0 0.4 -1.0 -1.3 -1.0 0.3 -0.3
Handedness (chirality/laterality): Left-handed 1.1 1.3 4.4 0.3 2.1 1.4 0.5 -1.6 -0.2 -0.8 0.7
Mood swings 0.4 0.8 3.2 -0.1 -0.2 1.8 -0.5 -0.0 0.7 -0.4 -1.4
Loneliness, isolation 0.4 0.5 1.4 -0.7 -0.1 -0.0 -0.8 -0.7 0.8 -0.5 -1.2
Long-standing illness, disability or infirmity 0.5 0.8 3.7 -0.5 -1.0 0.9 0.3 -1.9 -0.2 0.4 0.2
Ever had bowel cancer screening 1.0 1.1 3.7 0.9 -0.9 -0.1 1.1 1.9 -1.2 0.5 0.8
Diabetes diagnosed by doctor 1.2 1.9 4.6 0.7 0.2 1.7 1.1 -2.1 1.1 1.4 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.3 1.1 -0.1 -0.9 1.1 0.1 0.6 -0.9 1.0
Friendships satisfaction 0.4 0.4 1.4 -0.3 0.4 -1.0 -0.2 -0.5 -0.6 -1.2 -0.5
Qualifications: nursing, teaching 1.0 1.6 3.7 1.1 -0.3 -1.7 1.0 -0.8 -1.9 1.4 0.9
Commuting to job workplace: Walk 0.6 0.6 1.5 -1.0 0.6 -0.6 -1.2 0.1 -1.0 0.1 -0.8
Eye problems/disorders: Cataract 0.3 0.3 1.0 -0.3 0.2 -0.9 0.2 0.2 -0.2 -1.0 -0.5
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.8 0.6 -0.1 2.0 0.2 0.3 1.9 -0.7 0.3
Medication for cholesterol 1.0 1.5 3.7 -1.9 -0.4 -1.0 -1.4 -1.3 -0.2 0.7 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.0 -0.6 0.4 -0.4 -0.9 -1.0 0.6 -0.6 -0.8
Back pain experienced in last month 1.0 1.4 3.2 -0.1 -1.2 1.6 -1.4 -0.4 1.8 -1.0 0.9
Mineral and other dietary supplements 1.3 1.7 8.1 -0.5 2.0 -0.4 -0.3 -0.3 -0.6 -2.9 -0.8
Breast cancer (self-reported) 0.3 0.4 0.8 -0.2 -0.6 -0.6 -0.4 0.9 -0.9 -0.5 -0.0
Asthma (self-reported) 0.8 1.7 6.4 -1.0 -1.1 -1.4 -0.5 -1.5 -2.5 -0.3 -0.6
Osteoporosis (self-reported) 0.3 0.4 1.7 -0.3 -0.1 0.7 -0.2 -0.4 -0.7 -1.3 0.2
Osteoarthritis (self-reported) 1.0 1.3 3.0 1.7 0.1 1.3 1.3 1.4 1.1 -0.6 0.3
Medication: Aspirin 0.2 0.3 0.8 -0.4 -0.2 0.8 -0.2 -0.9 0.5 0.1 0.5
Medication: Gliclazide 1.3 1.4 3.5 -0.7 1.1 1.5 -0.6 -0.8 1.9 1.6 -0.5
Illnesses of father: None of the above (group 1) 0.9 1.1 3.8 -1.2 -0.2 -1.2 -0.7 1.0 -1.9 -0.5 -0.8
Smoking status: Current 0.6 1.0 2.9 0.2 1.0 1.7 -0.2 1.5 0.6 0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 9.9 0.3 1.6 1.7 0.5 3.1 0.5 -0.3 1.3
Whole body water mass 0.2 1.2 3.6 -0.8 0.7 0.4 -1.0 -1.9 -1.1 0.5 -1.4
Leg predicted mass (right) 0.2 1.1 3.8 -0.8 0.8 0.0 -0.9 -1.9 -0.8 -0.0 -1.6
Arm fat mass (left) 0.2 0.8 2.8 -0.5 -0.6 0.5 -0.4 -1.7 0.4 -0.7 -1.4
Number of self-reported non-cancer illnesses 0.7 1.2 7.1 0.2 -1.2 -0.0 0.6 -2.7 -0.5 0.1 0.6
Average weekly champagne plus white wine intake 1.0 1.4 5.5 1.0 -1.2 -2.4 0.9 -1.0 -0.5 1.1 0.0
Miserableness 0.6 1.1 4.5 0.1 1.3 1.2 -0.1 0.2 2.1 0.9 -0.7
Guilty feelings 1.2 1.8 3.3 -1.5 -0.5 1.4 -1.8 -1.7 -1.6 -0.9 -0.7
Wears glasses or contact lenses 1.1 1.3 2.8 -0.6 -1.2 -0.2 -1.4 -0.7 0.6 -1.7 -1.6
Ever taken oral contraceptive pill 0.6 0.7 1.6 -0.7 1.0 1.0 -0.8 1.3 -0.1 0.4 -0.8
Hearing aid user 1.3 1.4 3.1 0.4 -1.2 -0.9 0.7 -1.8 1.3 1.4 1.3
Mother’s age at death 0.7 0.8 2.3 1.2 0.4 -0.6 1.5 0.2 -0.2 1.4 0.5
Financial situation satisfaction 1.1 1.4 3.5 0.7 -0.4 -1.9 0.8 -1.8 1.6 -0.4 0.8
Tinnitus: Yes, now most or all of the time 1.4 1.6 6.0 1.4 -0.7 0.1 1.9 0.5 0.7 0.2 2.5
Commuting to job workplace: Public transport 1.7 2.0 5.0 -1.9 1.3 0.2 -1.9 1.0 -0.6 -0.7 -2.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.4 -0.4 1.2 -0.3 0.5 1.0 -1.0 0.6 -0.4
Medication: Blood pressure 1.1 2.1 4.6 2.0 -1.5 0.3 2.2 0.0 0.8 -0.2 2.1
Pain type(s) experienced in last month: Hip pain 1.0 1.2 5.0 -0.8 -1.1 1.0 -1.3 -0.3 0.1 -2.2 -0.2
Supplements: Fish oil (including cod liver oil) 0.7 1.0 4.5 0.6 -1.4 -0.0 0.4 0.2 0.8 2.1 0.1
High cholesterol (Self-reported) 0.3 0.5 1.6 1.3 0.1 0.5 1.2 -0.7 -0.0 0.3 0.7
Medication: Bendroflumethiazide 1.7 2.6 5.8 2.4 -1.5 -0.7 2.4 -1.0 1.2 1.8 0.9
Medication: Paracetamol 3.1 4.8 13.6 2.1 0.1 0.4 3.0 0.9 3.7 1.8 2.7
Medication: Lisinopril 0.6 0.8 1.9 1.2 0.3 1.1 1.4 -0.2 1.1 -0.4 0.5
Medication: Atorvastatin 0.5 0.6 3.0 0.1 1.7 0.9 0.4 0.7 0.2 -0.0 -0.9
Illnesses of father: High blood pressure 0.5 0.6 1.8 1.3 0.4 -0.3 1.4 -0.2 -0.3 -0.7 0.4
Alcohol drinker status: Never 0.5 0.6 2.0 1.0 1.1 0.0 0.9 1.4 0.1 -0.0 0.3
Ever smoked 1.0 1.7 2.8 0.9 1.7 1.6 0.9 0.6 -1.3 1.6 1.6
Basal metabolic rate 0.2 1.1 3.9 -0.7 0.7 0.6 -0.9 -2.0 -0.8 0.3 -1.4
Leg fat percentage (left) 0.3 1.2 3.4 1.1 -0.8 1.9 1.2 -0.8 1.0 -1.1 -0.2
Arm fat-free mass (left) 0.2 1.0 2.4 -0.4 0.7 1.5 -0.8 -1.5 -0.7 0.6 -1.0
Number of operations (self-reported) 0.3 0.5 2.0 -0.0 -0.4 1.1 0.3 1.4 0.5 0.4 0.1
Average weekly beer plus cider intake 1.7 2.4 9.2 -2.1 1.0 0.9 -1.1 1.3 -0.5 -3.0 -1.0
Irritability 0.7 1.2 4.3 1.9 -0.6 1.1 2.1 0.5 -0.2 0.2 0.5
Risk taking 1.3 1.9 4.6 1.9 0.4 0.1 1.8 2.1 -0.4 0.8 1.7
Ever had prostate specific antigen (PSA) test 1.9 2.2 5.8 2.4 0.1 -0.3 2.4 -1.3 0.9 0.5 1.9
Fractured/broken bones in last 5 years 1.0 1.2 2.4 0.2 0.0 -1.3 1.0 1.4 1.6 0.9 1.4
Age started oral contraceptive pill 0.8 1.0 4.1 -1.4 -0.1 -0.2 -0.9 -0.4 -2.0 -0.8 -0.7
Diastolic blood pressure, automated reading 1.8 5.5 16.5 1.0 -4.1 -3.4 1.5 -3.2 -0.9 -1.1 -0.4
Ever depressed for a whole week 0.4 0.4 1.4 -0.5 -0.5 0.1 -0.7 -1.2 -0.1 0.9 -0.6
Unable to work because of sickness or disability 0.8 1.1 5.1 0.0 -0.8 2.2 -0.4 -0.5 1.1 -0.9 0.7
Commuting to job workplace: Cycle 1.9 2.3 7.7 -0.3 2.8 1.6 -0.4 2.0 -1.7 -1.1 -0.2
Myopia 0.6 0.9 1.7 0.4 0.8 1.3 0.6 1.1 -1.3 1.3 0.1
Vascular/heart problems diagnosed by doctor 0.9 2.3 4.7 -1.5 1.7 0.8 -2.2 2.0 -1.1 -0.9 -1.5
Cholesterol lowering medication 0.3 0.5 1.2 1.0 0.7 0.0 0.8 0.5 0.0 -1.1 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 3.6 -0.0 0.4 1.9 0.1 0.6 -0.8 -1.2 -0.4
Pain experienced in last month 1.4 2.4 5.5 -1.7 0.5 -0.6 -0.9 0.1 -2.1 2.1 -2.3
Supplements: Calcium 0.5 0.5 2.6 0.3 -0.8 -0.2 0.2 0.3 0.7 1.6 0.2
Basal cell carcinoma (self-reported) 0.2 0.3 1.0 0.4 -0.7 0.5 0.5 -0.1 -1.0 0.0 0.1
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.6 -1.6 0.1 0.1 -1.6 -0.7 -1.0 0.2 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.7 0.1 1.3 -1.0 0.0 0.4 0.7 -0.4 -1.6
Heart disease (siblings) 0.2 0.2 0.6 -0.0 0.6 0.0 0.0 -0.6 0.8 -0.7 -0.1
Alcohol drinker status: Previous 0.4 0.5 1.0 0.6 0.9 0.5 0.8 0.0 0.7 -1.0 0.0
Pack years of smoking 0.6 0.9 5.5 0.1 0.9 -0.0 0.5 0.2 0.1 -2.3 0.6
Impedance of whole body 0.2 1.2 5.8 0.0 -0.4 0.4 0.2 2.4 0.3 -1.4 1.0
Leg fat mass (left) 0.2 0.8 2.7 0.3 -0.4 1.6 0.3 -1.6 0.5 -0.7 -0.8
Arm predicted mass (left) 0.2 0.9 3.3 -0.4 0.4 1.2 -0.8 -1.8 -0.6 0.7 -0.9