TWAS hub - MRVI1-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.325	0.0981	1.6e-03	0.144	NA	0.200	NA	0.207	7.4e-06	NA	1.0e-07	NA	6.0e-08
2	GTEx	Artery Tibial	0.218	0.0544	1.1e-05	0.137	NA	0.114	NA	0.118	7.5e-11	NA	3.0e-09	NA	1.8e-09
3	GTEx	Cells Transformed fibroblasts	0.146	0.0530	1.4e-03	0.066	NA	0.028	NA	0.009	1.2e-05	NA	3.1e-03	NA	6.3e-02
4	GTEx	Pancreas	0.494	0.0680	2.1e-08	0.464	NA	0.471	NA	0.477	9.7e-22	NA	3.8e-22	NA	1.7e-22
5	GTEx	Testis	0.679	0.0600	3.9e-10	0.504	NA	0.444	NA	0.482	2.1e-25	NA	1.4e-21	NA	5.4e-24
6	ROSMAP	Brain Pre-frontal Cortex	0.396	0.0439	0.0e+00	0.309	0.213	0.300	0.316	0.312	1.8e-40	7.3e-27	4.5e-39	2e-41	7.3e-41

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Hearing aid user	3.2	3.6	10.5	-0.5	-3.2	-1.2	-3.0	-0.6	-0.6
Smoking status: Current	3.0	4.8	9.3	2.1	2.5	0.5	3.1	2.1	2.0
Coronary Artery Disease (CAD)	2.9	3.5	5.4	-2.3	-0.3	-1.9	-1.4	-2.3	-2.2
High blood pressure (mother)	2.9	4.1	9.1	1.6	-3.0	1.8	-1.1	2.1	2.0
Alcohol usually taken with meals	2.9	4.6	6.4	2.0	-2.0	1.3	-2.3	2.5	2.5
Current tobacco smoking	2.8	4.6	10.7	1.9	2.7	0.2	3.3	1.8	1.7
Average weekly beer plus cider intake	2.8	4.1	7.0	-2.3	2.6	-0.8	2.1	-1.8	-1.8
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	5.2	-1.0	2.3	-1.9	2.1	-1.6	-1.5
Time employed in main current job	2.5	2.9	5.9	-2.4	0.9	-1.3	-0.1	-2.2	-2.0
Medication: Lansoprazole	2.5	2.9	6.5	-2.3	0.4	0.2	0.5	-2.5	-2.2
Illnesses of mother	2.5	3.1	12.0	-0.9	3.5	-0.5	1.2	-1.4	-1.4
Migraine (self-reported)	2.5	3.1	7.3	-0.3	2.7	-1.0	1.9	-1.6	-1.9
Hearing difficulty/problems with background noise	2.3	3.7	10.2	0.4	-3.2	1.7	-2.8	0.5	0.6
Birth weight	2.3	5.0	8.9	3.0	-1.9	0.2	-0.8	3.0	2.8
Worry too long after embarrassment	2.3	3.8	10.3	-1.5	3.2	-1.2	0.6	-2.1	-1.9
Medication: Atorvastatin	2.3	2.8	7.7	1.9	1.5	0.9	2.8	1.0	1.1
Peak expiratory flow (PEF)	2.2	5.2	12.0	-1.3	2.3	-3.5	3.1	-1.2	-1.1
Loud music exposure frequency	2.2	2.4	5.2	1.6	-1.0	1.0	0.3	2.2	2.3
Medication: Omeprazole	2.2	2.6	7.0	1.5	1.9	1.3	2.6	0.6	0.9
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	5.1	-2.3	-0.6	-1.5	-1.8	-1.5	-1.6
Handedness (chirality/laterality): Left-handed	2.2	2.7	11.2	0.9	-0.0	3.4	1.3	1.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	11.1	-1.4	2.6	-3.3	1.3	-1.9	-1.8
Supplements: Zinc	2.1	2.3	5.5	-0.5	-2.0	-2.4	-2.0	0.3	0.0
Impedance of leg (left)	2.0	9.7	14.8	-2.6	3.8	-3.8	1.4	-3.1	-3.3
Tinnitus: Yes, now most or all of the time	2.0	2.3	5.0	-1.7	0.3	-1.3	-1.0	-1.9	-2.2
High blood pressure (siblings)	1.9	2.7	4.7	1.9	-0.9	1.4	-1.0	2.2	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	5.3	-1.6	0.8	-0.5	0.0	-2.3	-2.2
Mineral and other dietary supplements	1.9	2.5	4.1	-1.6	1.9	0.6	1.1	-2.0	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	6.4	1.4	1.5	1.6	2.5	0.4	0.7
Impedance of whole body	1.9	9.8	13.4	-3.4	3.7	-3.7	0.7	-3.0	-3.3
Alzheimer’s Disease (in father)	1.8	2.0	3.3	1.4	-0.6	1.8	1.5	1.4	1.4
Prostate Cancer	1.8	2.6	5.7	-2.4	1.3	-0.5	-0.1	-2.0	-2.0
Severe depression (siblings)	1.8	2.1	4.1	-1.9	1.1	-0.3	0.4	-1.9	-2.0
Had major operations	1.8	2.1	5.2	2.3	0.6	0.1	2.0	1.3	1.2
Bipolar Disorder (2011)	1.7	1.7	3.8	-1.8	0.1	-1.9	-0.2	-1.1	-1.3
BMI	1.7	10.0	18.4	4.3	-1.0	4.1	1.4	3.1	3.4
Ever had hysterectomy (womb removed)	1.7	1.9	3.6	-1.9	0.5	0.1	0.6	-1.9	-1.9
Chronic bronchitis/emphysema (father)	1.7	1.9	5.1	0.9	-2.3	1.9	-0.4	0.9	1.0
Impedance of arm (left)	1.7	7.7	13.1	-3.6	2.4	-3.3	0.1	-2.7	-3.0
Medication: Gliclazide	1.7	1.9	3.7	1.8	-0.3	0.8	0.6	1.9	1.9
Commuting to job workplace: Cycle	1.7	2.1	5.4	-1.1	2.3	-0.3	2.0	-1.0	-0.8
Pain experienced in last month	1.7	2.8	6.9	1.6	-0.3	-0.5	0.5	2.6	2.6
Bipolar Disorder or Schizophrenia	1.6	3.9	9.8	-2.6	0.2	-3.1	-0.1	-1.9	-1.9
Schizophrenia (2018)	1.6	3.4	7.5	-2.7	-0.7	-1.6	-1.1	-2.1	-2.0
Primary Biliary Cirrhosis	1.6	2.2	4.7	-2.0	0.3	-1.0	0.3	-2.2	-1.9
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.8	1.0	0.4	1.6	1.5	1.4	1.7
Supplements: Glucosamine	1.6	2.1	4.5	2.1	-0.7	0.7	0.1	1.8	2.0
Falls in the last year	1.6	2.2	5.8	-0.2	2.2	-0.5	2.4	-1.0	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	7.5	-1.0	0.9	-2.7	0.1	-1.1	-1.3
Supplements: Vitamin C	1.6	1.9	3.5	1.2	-0.8	-0.7	-1.6	1.9	1.7
Number of self-reported non-cancer illnesses	1.6	2.7	8.8	1.7	-1.2	3.0	-0.9	1.0	1.2
Average weekly champagne plus white wine intake	1.6	2.2	4.0	0.9	-1.4	1.1	-1.3	2.0	1.8
Medication: Bendroflumethiazide	1.6	2.5	4.1	2.0	-1.9	1.2	-0.2	1.7	1.7
Alcohol drinker status: Previous	1.6	1.8	6.1	1.1	2.5	0.8	1.7	0.3	0.2
Waist Hip Ratio (WHR)	1.5	6.8	16.2	-1.9	4.0	-1.3	2.7	-2.4	-2.4
Medication: Metformin	1.5	2.1	4.9	2.0	-0.5	2.2	-0.0	1.2	1.3
Nervous feelings	1.5	2.9	8.5	-1.2	2.9	-0.5	0.5	-2.0	-1.7
Health satisfaction	1.5	2.0	4.6	-1.2	1.2	0.3	-0.1	-2.1	-2.2
Suffer from ‘nerves’	1.5	2.4	4.3	-0.8	1.2	-1.8	-1.1	-2.1	-1.9
Pack years of smoking	1.5	2.2	3.8	-1.1	1.9	-0.3	1.0	-1.9	-1.9
Bipolar Disorder (2018)	1.4	2.2	9.4	-0.7	1.2	-3.1	1.1	-0.4	-0.5
Impedance of leg (right)	1.4	7.0	11.8	-2.2	3.0	-3.4	0.8	-2.7	-2.9
Qualifications: CSEs or equivalent	1.4	1.8	5.2	-0.6	2.3	0.1	0.7	-1.8	-1.3
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	12.7	-1.5	2.3	-3.6	2.4	-1.3	-1.2
Glaucoma (self-reported)	1.4	1.7	3.4	1.5	0.1	0.1	1.1	1.8	1.8
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.6	4.3	-2.1	-0.2	-0.3	-1.1	-1.3	-1.5
Medication: Ibuprofen	1.4	1.7	6.0	-1.1	0.8	-2.5	-0.4	-1.1	-1.1
Illnesses of father: Heart disease	1.4	1.9	3.0	-1.7	-0.2	-1.6	-0.5	-1.7	-1.7
Schizophrenia (2014)	1.3	2.9	6.4	-2.5	-1.1	-1.7	-0.7	-1.8	-1.9
Lung FEV1/FVC ratio	1.3	6.8	22.9	-0.4	3.6	-1.7	4.8	-1.1	-0.9
Pack years adult smoking proportion	1.3	2.0	4.0	-0.9	2.0	-0.2	1.0	-1.7	-1.7
Impedance of arm (right)	1.3	6.2	9.5	-3.1	2.7	-2.7	0.8	-2.3	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	10.0	-1.4	2.3	-3.2	2.1	-1.2	-1.2
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.0	-1.7	1.5	-1.6	0.8	-1.4	-1.6
Neck or shoulder pain in last month	1.3	1.8	5.0	-1.0	0.1	-0.2	0.5	-2.2	-2.2
Medication: Allopurinol	1.3	1.8	6.2	0.9	-0.9	2.5	0.0	1.2	1.2
Pulse rate, automated reading	1.3	4.3	7.8	-2.1	1.4	-0.9	1.8	-2.8	-2.7
Arm fat-free mass (left)	1.3	6.4	13.5	2.9	-2.3	3.7	0.2	2.3	2.5
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.1	1.2	-1.0	1.8	0.6	1.3	1.6
Serious illness, injury or assault to yourself	1.2	1.4	4.5	1.6	-0.3	2.1	-0.3	0.9	0.7
Medication: Atenolol	1.2	1.5	3.6	1.4	-0.0	0.4	0.0	1.8	1.9
Body mass index (BMI)	1.2	5.1	16.6	2.5	-0.6	4.1	1.1	1.7	1.9
Medication: Simvastatin	1.2	1.8	5.4	0.7	-2.3	1.4	-0.9	0.9	1.2
Age at first live birth	1.2	2.1	4.2	1.9	-0.3	-0.0	-1.0	2.0	2.1
Overall health rating	1.2	2.5	5.9	1.3	2.2	2.4	1.5	0.4	0.6
Arm predicted mass (left)	1.2	6.2	13.8	2.8	-2.2	3.7	-0.0	2.2	2.4
Depression (Nagel 2018)	1.1	1.6	3.9	0.3	1.6	-0.6	2.0	-1.3	-1.0
Cardiovascular Disease	1.1	3.8	9.6	1.8	-2.0	3.1	-0.5	1.7	1.7
Vitamin and mineral supplements	1.1	1.4	2.9	-1.7	0.5	0.6	-0.2	-1.6	-1.6
Leg fat-free mass (left)	1.1	5.6	13.0	2.2	-2.4	3.6	-0.0	2.1	2.4
Fed-up feelings	1.1	1.9	5.7	-0.1	2.4	0.7	2.1	-0.7	-0.6
Number of incorrect matches in round	1.1	1.9	4.8	-1.8	-1.7	0.1	-2.2	-0.4	-0.6
Weight	1.1	5.5	15.9	2.4	-1.4	4.0	0.9	2.0	2.1
Trunk fat-free mass	1.1	6.2	11.4	2.6	-3.4	2.9	-0.8	2.2	2.3
Pulse rate	1.1	1.9	3.7	-1.0	1.3	-1.0	0.7	-1.9	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.1	-0.0	1.7	1.1	1.8	0.3	0.5
Medication: Cholesterol lowering	1.1	1.7	2.5	1.6	-1.2	1.4	-1.4	1.0	1.2
Trunk predicted mass	1.1	6.0	10.8	2.5	-3.3	2.9	-0.8	2.1	2.3
Blood clot in the leg (DVT)	1.1	1.4	2.2	1.1	-0.8	1.5	0.9	1.2	1.4
Hypertension (Self-reported)	1.1	3.0	6.1	1.4	-1.8	2.5	-0.8	1.9	1.6
Loneliness, isolation	1.1	1.6	5.1	2.3	0.4	1.3	-0.2	1.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	4.5	0.9	-0.4	2.1	0.2	1.1	1.1
Whole body water mass	1.1	6.1	11.6	2.5	-2.9	3.4	-0.4	2.2	2.4
Mother’s age at death	1.1	1.4	3.6	1.9	-0.1	-0.1	0.3	1.6	1.5
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.1	1.5	-1.2	-0.9	-0.6	1.3	1.4
Rheumatoid Arthritis	1.0	1.3	3.7	1.0	1.0	1.9	1.1	0.7	0.8
Ulcerative Colitis	1.0	1.4	2.5	1.5	-1.0	1.6	-0.0	0.9	1.4
Systolic blood pressure, automated reading	1.0	2.8	8.9	1.2	-2.1	3.0	-0.6	1.0	0.9
Medication: Co-codamol	1.0	1.1	2.1	1.5	0.0	0.5	1.4	1.2	1.1
High blood pressure	1.0	2.9	6.8	1.2	-1.9	2.6	-0.8	1.6	1.4
Stomach or abdominal pain in last month	1.0	1.3	2.1	1.3	-1.5	1.3	-0.4	0.8	1.2
Leg predicted mass (left)	1.0	5.5	12.8	2.2	-2.4	3.6	-0.1	2.1	2.3
Hair/balding pattern: Pattern 3	1.0	1.4	4.0	2.0	-0.8	0.1	-0.2	1.3	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.9	1.7	-0.9	1.1	-0.4	1.4	1.3
Headache pain in last month	1.0	1.7	7.6	0.4	2.8	-0.8	0.5	-0.7	-1.1
Comparative body size at age 10	1.0	2.7	7.3	0.9	-0.6	2.0	2.7	1.2	1.4
Whole body fat-free mass	1.0	5.8	10.8	2.5	-2.8	3.3	-0.4	2.1	2.3
Osteoporosis (self-reported)	1.0	1.2	2.8	-1.0	0.5	-0.5	-0.5	-1.6	-1.7
Basal metabolic rate	1.0	5.7	12.6	2.5	-2.5	3.5	-0.0	2.1	2.3
Diastolic blood pressure, automated reading	1.0	3.2	8.6	0.2	-2.7	2.9	-1.7	-0.2	-0.3
Worry (Nagel 2018)	0.9	1.8	4.0	-0.9	1.6	0.1	-0.5	-2.0	-1.8
Verbal and Numeric Reasoning (VNR)	0.9	2.2	9.8	-0.3	3.1	0.9	1.5	0.1	0.1
Neuroticism (2016)	0.9	1.3	4.0	-0.1	2.0	1.5	1.0	-0.5	-0.5
Blood Platelet Count	0.9	10.9	51.3	0.6	7.2	-0.5	3.1	-1.5	-1.2
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.5	0.9	1.6	-0.3	1.5	-1.1	-0.8
Age when periods started (menarche)	0.9	2.1	9.2	-0.5	-1.0	-0.3	-3.0	-0.9	-1.0
Past tobacco smoking	0.9	1.7	2.8	-1.7	0.5	-0.7	-1.2	-1.6	-1.6
Financial difficulties in last 2 years	0.9	1.2	3.9	2.0	0.7	0.4	0.8	1.0	0.8
Neuroticism score	0.9	1.9	7.1	-0.5	2.7	0.0	0.1	-1.5	-1.4
Hip circumference	0.9	3.9	14.1	1.8	-1.4	3.8	0.3	1.3	1.5
Mouth/teeth dental problems: Dentures	0.9	1.6	4.4	0.6	1.9	0.9	2.1	0.4	0.6
Arm fat mass (right)	0.9	3.7	11.8	2.2	-0.4	3.4	1.0	1.4	1.6
Arm fat-free mass (right)	0.9	4.6	9.5	2.2	-2.7	3.1	-0.4	1.6	1.8
Medication: Seretide 50 evohaler	0.9	1.1	2.7	-1.1	-1.0	0.1	-1.6	-0.8	-0.9
Leg fat mass (right)	0.9	3.5	11.0	2.1	0.3	3.3	1.6	1.0	1.3
Arm predicted mass (right)	0.9	4.5	9.4	2.2	-2.7	3.1	-0.1	1.6	1.8
Family relationship satisfaction	0.9	1.2	3.6	1.3	-0.7	1.9	-0.0	0.7	0.9
Leg fat mass (left)	0.9	3.3	11.2	2.0	0.6	3.3	1.6	0.9	1.1
Schizophrenia vs Biploar Disorder	0.8	1.1	2.7	0.1	-1.6	1.6	-1.0	-0.3	-0.2
Systolic Blood Pressure	0.8	4.1	15.1	1.0	-1.9	3.9	-1.3	1.4	1.2
Neuroticism	0.8	1.9	4.9	-1.1	2.2	0.2	-0.4	-1.6	-1.6
Hearing difficulty/problems: Yes	0.8	1.3	4.5	0.3	-2.1	1.1	-1.2	-0.4	-0.4
Forced vital capacity (FVC)	0.8	3.2	10.1	-1.6	1.6	-3.2	1.4	-0.9	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.0	-1.4	0.1	-0.4	-0.5	-1.3	-1.4
Qualifications: College or University degree	0.8	2.6	5.6	1.2	0.2	1.9	0.4	2.4	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.2	-0.5	0.7	-1.0	0.1	-1.5	-1.2
Number of full sisters	0.8	1.0	5.1	-0.4	-2.3	0.1	-0.6	0.2	-0.2
Leg fat-free mass (right)	0.8	4.2	11.1	1.7	-2.0	3.3	0.1	1.8	2.0
Diabetes diagnosed by doctor	0.8	1.3	3.6	1.3	-0.2	1.9	-0.0	1.1	1.1
Leg predicted mass (right)	0.8	4.0	11.2	1.7	-1.9	3.3	0.2	1.7	1.9
Arm fat mass (left)	0.8	3.2	11.5	1.8	-0.3	3.4	1.1	1.2	1.3
Guilty feelings	0.8	1.2	6.0	-0.1	2.4	0.8	-0.3	-0.3	-0.4
Leg fat percentage (left)	0.8	2.8	6.6	1.6	1.7	2.6	2.0	0.3	0.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.1	1.0	-1.4	1.4	-0.3	0.2	0.1
Blood White Count	0.7	5.3	13.0	3.6	1.5	1.9	1.6	2.1	2.4
Smoking Status	0.7	1.8	5.2	0.8	1.5	-0.6	2.3	1.1	1.0
Lung FVC	0.7	3.6	11.8	-1.9	1.2	-3.4	0.2	-1.4	-1.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.8	1.3	-0.2	1.2	-0.2	0.9	1.1
Diabetes (father)	0.7	0.8	3.3	-0.1	0.9	-0.8	1.8	-0.3	-0.3
Taking other prescription medications	0.7	1.1	2.8	0.1	0.5	1.7	0.8	-1.2	-1.1
Multivitamins +/- minerals	0.7	0.9	1.9	1.4	0.4	-0.2	0.6	1.1	1.3
Had menopause	0.7	0.9	1.2	-0.9	-1.1	-0.6	-1.1	-0.7	-1.1
Mouth/teeth dental problems	0.7	1.0	2.6	-0.9	-0.9	-1.1	-1.6	-0.5	-0.7
Medication: Ramipril	0.7	0.9	2.1	0.6	-1.0	1.4	-0.5	0.8	0.9
Fluid intelligence score	0.7	1.4	1.9	0.6	1.3	1.3	0.9	1.2	1.4
Arm fat percentage (right)	0.7	2.6	9.1	1.5	0.9	3.0	1.5	0.7	0.9
Length of working week for main job	0.7	0.8	1.7	-0.6	1.0	0.4	-0.2	-1.2	-1.3
Exposure to tobacco smoke at home	0.7	0.8	1.1	1.0	-1.0	0.9	-0.8	0.8	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.7	-1.1	-0.3	-0.2	-0.5	-1.2	-1.3
Leg fat percentage (right)	0.7	2.5	6.6	1.7	1.3	2.6	1.8	0.5	0.7
Shortness of breath walking on level ground	0.7	0.9	1.9	-0.9	-0.6	0.4	-0.9	-1.1	-1.4
Whole body fat mass	0.7	2.9	9.8	1.8	0.6	3.1	1.6	0.7	0.9
Age at last live birth	0.7	1.0	1.4	1.0	1.1	-0.8	-0.6	1.1	1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.7	1.0	1.0	-0.8	0.9	-0.5	1.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.5	-1.1	-0.7	0.1	-0.2	-1.1	-1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.6	0.1	0.9	1.3	-0.2	-1.3	-1.2
Supplements: Calcium	0.7	0.8	1.5	0.7	-1.2	-0.7	-1.0	0.8	0.7
Neuroticism (Nagel 2018)	0.6	1.5	5.8	0.1	2.4	0.7	0.7	-1.1	-0.9
Lupus	0.6	0.9	2.7	-1.6	-0.2	-0.7	1.0	-0.8	-0.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.0	-0.5	1.4	1.2	0.3	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.3	0.2	1.3	1.6	1.8	0.5	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	0.4	-0.2	1.0	1.3	0.5	0.7
Waist circumference	0.6	2.3	9.4	1.5	-0.1	3.1	1.1	0.6	0.7
Heart attack	0.6	0.8	1.8	1.4	0.7	-0.6	-0.6	0.8	1.1
Diabetes (self-reported)	0.6	1.0	3.6	1.2	-0.1	1.9	-0.6	0.6	0.5
Birth weight of first child	0.6	1.1	4.2	-0.3	2.0	0.3	1.6	-0.2	0.0
Pulse wave reflection index	0.6	0.8	1.7	1.1	1.1	0.3	1.3	0.4	0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	4.1	0.5	-0.1	0.7	-2.0	0.3	0.0
Forced vital capacity (FVC), Best measure	0.6	2.3	8.5	-1.4	1.4	-2.9	0.8	-0.6	-0.7
Body fat percentage	0.6	2.4	7.0	1.2	1.5	2.6	1.9	0.2	0.3
Number of children fathered	0.6	0.6	2.7	-0.0	-1.0	0.3	-1.6	0.1	-0.0
Pulse wave peak to peak time	0.6	0.7	1.2	0.3	-1.1	0.6	-0.2	1.1	1.1
Medication: Blood pressure	0.6	1.1	1.9	1.4	-0.8	1.2	-0.5	1.0	1.3
Knee pain experienced in last month	0.6	0.9	1.7	-0.5	1.3	0.1	-0.4	-1.3	-1.2
Qualifications: nursing, teaching	0.6	0.9	1.7	0.7	-0.8	0.5	-1.1	1.3	1.1
Wears glasses or contact lenses	0.6	0.7	3.3	0.2	-0.2	1.8	0.8	-0.0	0.2
Medication: Lisinopril	0.6	0.7	1.6	0.8	1.2	0.7	0.9	0.6	0.5
Ever smoked	0.6	1.1	1.9	1.2	0.4	-0.1	1.1	1.4	1.3
Ever depressed for a whole week	0.6	0.7	1.3	1.0	-1.0	0.3	-1.1	0.6	0.7
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.0	1.4	0.8	-0.3	-0.4	0.8	1.1
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	-0.9	0.3	-0.6	0.7	-0.9	-0.9
Alzheimer’s Disease (including proxy)	0.5	0.7	2.4	0.4	-0.4	0.8	1.6	0.7	0.6
Major Depression (MDD)	0.5	0.6	1.9	1.4	0.0	0.2	0.6	0.8	0.7
Age at First Birth	0.5	0.8	1.5	0.6	-0.9	0.8	-0.1	1.2	1.2
Respiratory disease	0.5	1.1	3.4	-0.9	-1.0	1.8	-1.0	-0.4	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.2	0.8	0.3	1.8	0.1	1.0	0.9
Trunk fat percentage	0.5	2.0	6.8	0.7	1.2	2.6	1.8	0.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.1	0.5	0.7	-1.1	0.7	-1.0	-0.9
Trunk fat mass	0.5	2.3	9.4	1.4	0.1	3.1	1.3	0.6	0.7
Hair/balding pattern: Pattern 2	0.5	0.6	1.7	0.5	-0.0	1.3	0.9	0.6	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.0	-0.9	0.1	-0.5	-1.4	-0.5	-0.6
Illnesses of siblings	0.5	0.7	1.1	-1.0	0.4	-0.8	0.8	-1.0	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.8	0.2	0.5	0.8	1.9	-0.4	-0.4
Noisy workplace	0.5	0.6	1.4	0.0	-0.1	1.2	-0.0	-1.2	-0.8
Asthma	0.5	0.9	3.8	0.5	-0.4	2.0	-0.7	0.7	0.5
Exposure to tobacco smoke outside home	0.5	0.6	2.1	0.2	-0.3	1.2	1.5	-0.1	-0.1
Emphysema/chronic bronchitis	0.5	0.5	1.6	-1.1	0.5	0.2	1.2	-0.1	-0.1
Heart disease (mother)	0.5	0.6	1.5	-1.2	-0.0	-0.5	0.4	-1.0	-0.7
Arm fat percentage (left)	0.5	2.0	7.8	1.2	0.7	2.8	1.3	0.5	0.6
Long-standing illness, disability or infirmity	0.5	0.7	1.8	1.0	-0.4	1.4	-1.1	0.1	0.2
Friendships satisfaction	0.5	0.6	2.1	1.0	0.4	1.4	0.1	0.5	0.6
Eye problems/disorders: Cataract	0.5	0.6	1.2	1.0	0.6	0.9	1.1	0.2	0.3
Breast cancer (self-reported)	0.5	0.6	2.1	-0.2	0.6	-1.4	-0.1	-0.7	-0.7
Asthma (self-reported)	0.5	1.1	4.4	0.6	-0.4	2.1	-0.5	0.9	0.7
Osteoarthritis (self-reported)	0.5	0.7	1.3	-0.4	0.8	-0.6	1.1	-1.0	-0.8
Financial situation satisfaction	0.5	0.6	1.9	0.6	-0.1	1.4	-0.5	-0.7	-0.6
High cholesterol (Self-reported)	0.5	0.8	3.6	0.2	-1.9	1.2	-0.2	-0.2	-0.1
Number of operations (self-reported)	0.5	0.7	2.3	1.5	-0.3	-0.6	0.6	0.9	0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.8	-1.1	1.2	-2.0	0.5	-1.1	-1.0
Cholesterol lowering medication	0.5	0.7	1.6	0.6	-0.8	1.1	1.2	0.3	0.5
Breast Cancer	0.4	1.0	5.2	0.1	-0.3	0.8	-2.3	-0.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-1.0	-0.7	-0.1	-0.3	-0.7	-0.9
Angina	0.4	0.6	1.0	0.8	1.0	0.3	0.0	1.0	0.9
Townsend deprivation index at recruitment	0.4	0.5	2.2	0.4	0.7	-1.5	-0.3	-0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	3.1	0.1	1.1	0.6	1.8	0.4	0.8
Worrier / anxious feelings	0.4	0.8	3.5	0.6	0.4	1.9	0.9	0.1	0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.8	0.8	-1.1	-0.1	-0.1	1.3	1.1
Prospective memory result	0.4	0.5	1.1	-0.2	-0.2	-1.0	-1.0	-0.7	-0.5
Hair/balding pattern: Pattern 4	0.4	0.9	1.9	-1.3	1.4	-1.2	0.4	-0.3	-0.5
Gout (self-reported)	0.4	0.6	2.1	0.3	-0.9	1.5	-0.2	0.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.8	-0.7	-0.1	-0.9	-0.4	-1.4	-1.3
Mean time to correctly identify matches	0.4	0.8	2.2	0.7	-1.1	1.5	0.3	0.4	0.7
Alcohol intake frequency.	0.4	0.8	2.3	1.5	1.0	-1.1	0.7	0.0	-0.2
Chest pain or discomfort	0.4	0.5	1.3	-0.6	-0.1	1.2	0.7	-0.8	-0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.4	0.7	-1.2	-0.1	-1.1	0.2	0.1
Mood swings	0.4	0.8	1.7	0.9	0.7	1.3	1.2	-0.1	0.1
Commuting to job workplace: Walk	0.4	0.4	1.6	-0.2	-0.4	-1.3	-0.5	0.4	0.4
Back pain experienced in last month	0.4	0.6	1.2	0.0	0.3	0.4	-1.0	-1.1	-1.1
Ever taken oral contraceptive pill	0.4	0.5	1.1	-0.9	0.6	-0.8	1.0	-0.1	-0.2
Commuting to job workplace: Public transport	0.4	0.4	1.6	-0.4	0.8	-0.4	1.3	-0.2	-0.1
Myopia	0.4	0.6	0.8	0.8	0.2	-0.9	0.5	0.9	0.9
Depressed Affect (Nagel 2018)	0.3	0.6	1.3	0.5	1.2	1.0	1.1	-0.1	0.1
Ulcerative Colitis (UC)	0.3	0.7	2.7	0.2	-0.5	1.6	0.8	0.1	0.4
Reaction Time	0.3	0.6	1.8	0.4	0.2	1.2	1.3	-0.1	0.2
HbA1C	0.3	0.3	0.8	-0.9	0.4	0.4	0.1	-0.7	-0.7
LDL Cholesterol	0.3	0.5	1.6	-0.2	-0.8	0.8	-1.3	0.0	0.2
Chronotype (morning person)	0.3	0.6	1.4	-0.6	-0.0	0.7	0.7	-1.2	-0.9
Average weekly spirits intake	0.3	0.4	2.0	0.4	0.4	1.4	-0.0	-0.0	0.1
Diabetes (mother)	0.3	0.4	1.0	-0.2	-0.6	0.2	-1.0	-0.6	-0.7
Average weekly fortified wine intake	0.3	0.3	1.4	0.4	0.0	-1.2	-0.5	0.0	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.5	-0.4	1.9	-0.7	0.1	-0.4	-0.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.9	0.6	-0.4	-1.0	-0.4	0.4	0.4
Happiness	0.3	0.4	0.9	0.9	0.2	0.9	0.7	-0.1	0.2
Depression (self-reported)	0.3	0.4	1.7	1.3	-0.5	0.4	-0.5	-0.2	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	-0.2	0.8	-0.5	0.1	-0.7	-0.8
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.2	0.7	-0.1	0.6	-0.8	-0.6
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.8	0.9	0.0	-0.7	0.7	0.8	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.8	0.2	0.2	-0.9	0.4	-0.6	-0.7
Medication: Amlodipine	0.3	0.4	0.9	0.1	-0.9	0.1	-0.8	0.4	0.6
Angina (self-reported)	0.3	0.4	0.8	0.6	0.9	0.3	0.0	0.8	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.2	0.6	-1.1	0.3	-0.5	-0.7
Smoking status: Previous	0.3	0.4	1.2	0.6	-1.1	0.2	0.4	0.6	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.9	-0.2	-0.4	1.4	0.8	0.2	0.2
Medication: Paracetamol	0.3	0.5	2.5	-0.2	1.6	-0.7	0.3	0.2	-0.0
Alcohol drinker status: Never	0.3	0.3	1.3	0.5	0.1	-0.5	1.1	0.3	0.3
Fractured/broken bones in last 5 years	0.3	0.4	1.3	-0.8	0.3	-1.2	0.2	-0.1	-0.4
Unable to work because of sickness or disability	0.3	0.3	0.8	0.5	-0.1	0.6	-0.2	-0.9	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.9	0.2	1.7	-0.4	-0.9	0.3	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.6	0.4	-0.9	1.3	0.4	0.0	0.5
Ovarian Cancer	0.2	0.3	0.8	-0.2	-0.4	-0.4	-0.6	-0.7	-0.9
Mean Putamen Volume	0.2	0.3	0.5	-0.0	0.7	-0.3	0.7	0.5	0.6
HDL Cholesterol	0.2	0.4	1.3	0.2	1.1	-0.7	0.6	-0.1	-0.1
Triglycerides	0.2	0.4	1.2	-0.6	-1.1	0.1	-0.6	-0.5	-0.4
Allergy or Eczema	0.2	0.5	2.0	-0.4	1.4	-0.3	0.1	-0.6	-0.4
Tanning	0.2	2.0	7.0	-0.4	-1.1	-1.6	-2.6	-0.6	-0.7
Number of treatments/medications taken	0.2	0.4	1.4	-0.0	-0.1	1.2	0.4	-0.6	-0.7
Sensitivity / hurt feelings	0.2	0.3	1.4	0.2	1.2	-0.2	0.2	-0.3	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.6	0.7	-0.4	-0.3	-0.1	0.5	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.4	-0.3	-0.2	-0.8	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.0	1.0	0.4	0.2	-0.4	0.4	0.5
Had other major operations	0.2	0.2	0.6	0.7	0.4	0.2	0.8	-0.2	-0.4
Pain all over the body in last month	0.2	0.2	0.5	0.6	-0.2	0.7	0.7	0.0	-0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.8	0.8	0.2	-0.9	-0.0	-0.0	0.1
Breastfed as a baby	0.2	0.3	1.0	-0.3	0.1	-0.8	1.0	0.1	-0.0
Tense / ‘highly strung’	0.2	0.3	0.4	-0.1	0.4	0.5	-0.5	-0.6	-0.7
Medication: Paracetamol	0.2	0.4	0.8	0.3	0.9	-0.6	0.7	0.7	0.4
Number of full brothers	0.2	0.3	1.2	0.4	-0.3	-0.5	-1.1	0.3	0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.5	0.7	0.8	0.4	-0.5	-0.5
Eye problems/disorders: None of the above	0.2	0.3	0.9	-0.2	-0.6	-0.7	-0.9	0.0	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	0.1	-0.8	0.3	-0.4	-0.3	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	0.1	-0.7	0.7	-0.6	0.3	0.5
Leg pain on walking	0.2	0.3	0.8	0.2	0.0	-0.2	0.1	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-1.1	-0.6	-0.8	0.4	-0.2	0.1
Average weekly red wine intake	0.2	0.4	1.1	-0.3	-0.0	1.0	-1.0	0.0	-0.1
Ever had bowel cancer screening	0.2	0.2	0.7	-0.5	-0.6	-0.8	0.3	0.2	0.2
Medication for cholesterol	0.2	0.3	1.7	-0.0	-0.0	0.0	-1.3	-0.2	-0.1
Medication: Aspirin	0.2	0.2	0.7	0.0	-0.1	-0.1	-0.4	-0.7	-0.8
Illnesses of father: None of the above (group 1)	0.2	0.3	1.5	0.0	1.2	-0.5	0.4	-0.0	0.1
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	0.1	0.4	-0.5	0.9	0.4	0.5
Risk taking	0.2	0.3	0.7	0.6	0.2	-0.4	0.4	0.9	0.6
Age started oral contraceptive pill	0.2	0.2	0.3	-0.4	0.4	0.6	0.5	-0.3	-0.4
Heart disease (siblings)	0.2	0.3	0.5	-0.5	0.7	-0.1	-0.1	-0.7	-0.6
Body Mass Index (BMI) (2010)	0.1	0.2	1.0	-0.3	-0.1	-1.0	0.1	-0.0	-0.1
Crohns Disease (2012)	0.1	0.2	0.6	0.8	-0.3	0.2	0.1	0.2	0.4
Fasting Glucose	0.1	0.1	0.3	0.1	0.5	-0.1	0.2	0.3	0.2
Blood Eosinophil Count	0.1	0.6	2.4	-0.1	0.8	-0.7	1.6	-0.0	0.0
Heel T-Score	0.1	0.7	1.3	1.1	-0.7	1.0	1.0	0.4	0.5
Height	0.1	1.7	7.0	0.0	-2.6	1.2	0.4	0.9	0.8
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.3	-0.2	-0.5	-0.4	-0.8	-0.8
Relative age of first facial hair	0.1	0.1	0.4	0.6	-0.3	0.6	0.0	-0.1	-0.2
Relative age voice broke	0.1	0.2	0.7	0.6	-0.1	-0.3	0.8	0.1	0.3
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.1	-0.5	0.1	0.4	-0.5	-0.6
Sitting height	0.1	0.7	2.4	0.0	-1.6	0.9	-0.7	0.5	0.4
Qualifications: None of the above	0.1	0.3	0.5	0.7	0.5	0.2	0.7	-0.5	-0.3
Allergy	0.1	0.3	0.8	0.7	-0.9	-0.1	0.6	0.3	0.0
Father’s age at death	0.1	0.2	0.8	0.2	0.3	-0.4	0.9	-0.2	-0.1
Number of live births	0.1	0.1	0.3	-0.6	0.5	0.1	-0.1	-0.1	-0.1
Lung cancer (father)	0.1	0.1	0.2	0.2	0.5	0.2	0.4	0.1	0.2
Standing height	0.1	0.7	3.3	-0.0	-1.8	-0.2	-0.3	0.6	0.5
Comparative height size at age 10	0.1	0.8	1.6	0.6	-1.1	0.4	0.0	1.3	1.1
Medication: Aspirin	0.1	0.1	0.2	0.2	-0.3	0.2	-0.1	-0.5	-0.4
Miserableness	0.1	0.2	0.4	0.6	0.3	-0.7	0.4	0.4	0.5
Medication: Blood pressure	0.1	0.3	0.7	-0.1	0.6	0.5	0.8	0.4	0.1
Illnesses of father: High blood pressure	0.1	0.1	0.3	0.1	-0.2	0.6	-0.1	-0.0	-0.3
Basal cell carcinoma (self-reported)	0.1	0.1	0.5	-0.7	-0.1	-0.1	-0.5	-0.2	-0.2
Crohns Disease (2017)	0.0	0.1	0.4	-0.1	-0.1	-0.1	0.2	-0.6	-0.3
Blood Red Count	0.0	0.4	1.0	0.3	-0.0	-1.0	-0.8	0.6	0.4
Hair Pigment	0.0	0.3	1.2	-0.3	-0.3	-1.1	0.2	-0.6	-0.5
Hand grip strength (left)	0.0	0.1	0.3	-0.2	-0.5	0.3	0.1	-0.1	-0.3
Hand grip strength (right)	0.0	0.1	0.3	-0.1	-0.6	0.2	-0.2	0.2	-0.1
Maternal smoking around birth	0.0	0.1	0.1	0.3	0.4	0.1	0.3	-0.1	-0.2
Irritability	0.0	0.1	0.2	0.1	0.4	0.0	0.4	-0.2	-0.2

Hub : Genes

MRVI1-AS1

Models

Trait associations