Hub : Genes

MSX1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.189	0.067	0.0025	0.145	NA	0.084	NA	0.106	2.1e-08	NA	2.3e-05	NA	2.0e-06
2	GTEx	Cells Transformed fibroblasts	0.168	0.060	0.0021	0.005	NA	0.036	NA	0.016	1.3e-01	NA	9.9e-04	NA	2.0e-02
3	GTEx	Pituitary	0.551	0.128	0.0062	-0.011	NA	-0.009	NA	0.025	7.6e-01	NA	6.0e-01	NA	7.8e-02
4	TCGA	Bladder Urothelial Carcinoma	0.083	0.041	0.0092	-0.003	0.013	0.003	NA	-0.003	7.7e-01	0.026	1.8e-01	NA	9.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	2.2	0.7	1.5	0.9	0.7
Bipolar Disorder or Schizophrenia	0.5	1.1	3.6	0.4	0.2	-0.8	1.9
Depressed Affect (Nagel 2018)	1.1	2.4	7.1	0.8	-1.3	2.7	-0.0
Depression (Nagel 2018)	1.0	1.6	4.1	-1.1	-2.0	-0.2	-1.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.9	1.4	0.7	0.6	1.0
Neuroticism (Nagel 2018)	0.7	1.6	5.9	-0.0	-0.2	2.4	-0.8
Schizophrenia (2018)	0.9	1.8	3.6	0.4	-0.9	-1.6	1.9
Schizophrenia vs Biploar Disorder	2.6	3.5	7.5	-2.7	-1.3	-2.2	0.1
Worry (Nagel 2018)	1.0	2.2	4.4	-0.2	-0.3	2.1	-2.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.8	0.6	0.0	-0.9	0.3
Alzheimer’s Disease (in father)	0.6	0.6	1.4	0.1	1.2	0.2	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.0	0.8	-0.9	0.5
Crohns Disease (2017)	0.5	1.1	3.3	-0.4	1.8	0.9	-0.4
Irritable Bowel Disease (IBD)	0.6	1.5	2.1	-1.1	1.4	1.4	0.7
Ulcerative Colitis (UC)	0.5	1.0	2.0	-1.0	0.6	0.7	1.4
Major Depression (MDD)	0.8	1.0	2.5	-0.7	-0.9	-1.6	-0.4
Reaction Time	0.2	0.3	0.5	-0.7	-0.5	-0.0	0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.0	0.0	0.1	1.0	0.4
Breast Cancer	0.4	0.9	1.2	0.8	-0.6	-1.1	-1.1
Ovarian Cancer	1.1	1.4	4.5	2.1	-0.8	0.6	0.2
Prostate Cancer	1.8	2.5	7.4	-0.3	2.7	1.6	0.3
Age at First Birth	0.2	0.2	0.5	0.4	0.5	0.7	0.4
Bipolar Disorder (2011)	0.9	0.9	3.2	1.8	0.1	0.5	-0.4
Body Mass Index (BMI) (2010)	1.3	1.8	4.5	-1.6	-0.6	0.1	-2.1
Coronary Artery Disease (CAD)	1.1	1.4	4.1	-2.0	0.0	-0.9	-0.7
Crohns Disease (2012)	0.2	0.4	1.0	0.1	1.0	-0.3	-0.6
Mean Putamen Volume	2.4	2.8	6.4	0.4	-2.1	-2.5	-0.2
Fasting Glucose	1.2	1.5	2.8	-1.7	-1.2	-1.3	0.3
HbA1C	1.1	1.2	4.2	0.3	-0.6	-2.0	-0.4
HDL Cholesterol	0.6	0.9	3.1	-0.1	-0.6	-1.8	0.5
LDL Cholesterol	0.3	0.5	1.4	0.5	-1.2	-0.3	-0.5
Lupus	0.6	0.9	2.3	-1.1	1.5	-0.0	-0.2
Neuroticism (2016)	0.3	0.4	1.0	-0.7	0.3	-0.1	-1.0
Primary Biliary Cirrhosis	3.0	4.3	8.3	-1.1	2.9	-0.9	-2.6
Rheumatoid Arthritis	0.7	0.9	3.4	0.1	0.5	1.9	-0.3
Schizophrenia (2014)	0.7	1.4	3.5	0.0	-0.3	-1.5	1.9
Triglycerides	0.7	1.2	3.0	-0.3	-0.8	1.7	-1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.8	-0.6	1.4	0.9	0.7
Ulcerative Colitis	0.9	1.3	2.9	-0.9	1.1	0.7	1.7
Blood Eosinophil Count	0.1	0.9	1.5	-1.2	-1.2	0.7	0.6
Blood Platelet Count	0.4	4.6	16.4	-0.2	0.3	4.0	1.4
Blood Red Count	0.1	1.1	2.8	0.9	0.8	1.7	-0.4
Blood White Count	0.1	1.0	2.3	-0.7	-0.9	1.5	-0.5
Heel T-Score	0.1	0.8	1.9	-0.7	0.9	-1.4	0.0
BMI	0.3	2.0	5.1	-1.0	-2.3	-0.5	-1.2
Height	0.4	8.4	27.6	-1.0	-2.1	-5.2	-0.7
Waist Hip Ratio (WHR)	0.1	0.3	1.1	0.4	-0.1	-1.1	0.2
Systolic Blood Pressure	0.7	3.5	7.1	-1.2	2.7	2.0	-1.2
Smoking Status	0.6	1.3	3.3	-0.8	-1.8	-1.2	-0.0
Allergy or Eczema	1.3	3.3	7.2	-1.9	1.6	2.7	0.2
Cardiovascular Disease	0.6	1.9	3.6	0.0	1.6	1.2	-1.9
Hypothyroidism (self reported)	0.3	0.7	1.7	-0.0	1.3	0.2	1.0
Respiratory disease	0.6	1.3	2.3	-0.7	-1.2	1.5	-0.9
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.5	0.3	0.4	0.5	-0.7
Lung FEV1/FVC ratio	0.4	2.2	6.8	1.1	-2.6	-0.3	-0.6
Lung FVC	0.3	1.7	3.3	-1.8	1.8	0.2	0.4
Neuroticism	1.0	2.3	8.6	0.6	-0.2	2.9	-0.6
Chronotype (morning person)	0.7	1.6	2.4	1.6	1.3	-1.5	-0.1
Hair Pigment	0.1	3.8	4.7	-2.2	-2.0	-1.6	1.9
Tanning	0.1	1.7	5.5	-0.6	0.0	-2.3	-0.9
Hand grip strength (left)	0.3	0.8	1.7	-1.1	0.6	-1.3	-0.2
Number of treatments/medications taken	1.5	2.7	5.6	-2.0	-0.1	1.1	-2.4
Average weekly spirits intake	1.3	1.7	5.8	2.4	0.1	0.1	0.9
Sensitivity / hurt feelings	1.3	2.2	6.8	-0.0	0.8	2.6	1.1
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.9	0.6	-0.8	1.4	0.4
Hearing difficulty/problems: Yes	0.7	1.1	2.2	-1.5	-1.3	-0.0	-0.8
Relative age of first facial hair	0.4	0.8	2.2	-0.1	0.2	1.5	0.9
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	3.9	0.5	1.2	2.0	-1.1
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.3	-1.8	0.1	0.9	-0.4
Ever had hysterectomy (womb removed)	1.6	1.8	5.4	-1.2	0.2	0.6	-2.3
Systolic blood pressure, automated reading	1.6	4.6	11.8	-3.4	1.3	0.6	-2.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	2.1	0.5	-0.1	-0.1	1.4
Angina	0.2	0.3	0.9	0.1	0.1	-0.3	-0.9
Medication for hormone replacement therapy	0.2	0.3	0.9	0.2	0.9	0.3	0.1
Vitamin and mineral supplements	1.3	1.7	6.0	0.4	-2.5	-0.9	-0.1
Supplements: Zinc	0.7	0.7	1.4	-1.0	-1.2	-0.1	0.6
Medication: Co-codamol	0.4	0.5	0.6	-0.8	-0.8	0.4	-0.7
Medication: Metformin	1.4	2.0	4.5	1.6	2.1	0.2	-0.9
Diabetes (father)	0.4	0.5	1.2	-0.3	-0.5	0.6	1.1
Diabetes (mother)	2.6	3.3	9.3	-0.6	0.2	3.1	-1.9
Severe depression (siblings)	0.5	0.6	1.3	-1.1	-1.0	-0.1	-0.5
Pack years adult smoking proportion	1.0	1.5	4.0	0.9	-0.1	1.0	2.0
Impedance of leg (right)	0.3	1.5	2.6	1.4	0.8	0.8	1.6
Leg fat-free mass (left)	0.4	2.2	3.2	-0.9	-1.7	-1.8	-1.3
Trunk fat percentage	0.8	3.3	11.5	0.1	-3.4	-0.7	-1.1
Hand grip strength (right)	0.7	1.8	3.1	-1.8	0.7	-1.6	-0.9
Townsend deprivation index at recruitment	2.0	2.8	9.4	1.2	0.0	0.6	3.1
Current tobacco smoking	1.2	1.9	5.1	-0.5	-1.6	-2.2	0.2
Average weekly fortified wine intake	1.3	1.5	2.9	-1.3	1.1	1.7	0.5
Maternal smoking around birth	0.3	0.4	0.7	-0.8	-0.7	0.6	0.4
Fed-up feelings	1.0	1.8	4.2	-0.2	-2.1	1.6	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.5	-1.6	-1.4	0.1	-0.1
Relative age voice broke	0.5	0.8	1.9	-1.4	0.3	1.0	0.2
Taking other prescription medications	1.9	3.0	7.9	-1.0	0.5	1.6	-2.8
Age when periods started (menarche)	0.1	0.2	0.5	0.1	0.6	-0.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.2	-0.6	-0.4	1.1	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	8.6	-0.8	0.3	2.9	0.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.0	-0.7	-1.4	-0.7	-0.2
Qualifications: CSEs or equivalent	1.2	1.6	3.6	1.3	0.0	1.2	1.9
Serious illness, injury or assault to yourself	1.1	1.4	3.1	-0.5	-0.3	1.4	-1.8
High blood pressure	1.1	3.1	6.2	-1.8	1.3	0.9	-2.5
Hayfever, allergic rhinitis or eczema	1.5	3.2	5.2	-0.9	2.3	2.3	1.2
Multivitamins +/- minerals	0.6	0.7	2.1	-0.6	1.5	0.7	0.1
Stomach or abdominal pain in last month	1.3	1.6	3.9	0.4	-2.0	0.1	-1.6
Supplements: Glucosamine	0.4	0.5	0.7	-0.7	-0.8	-0.3	0.7
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.9	-1.0	1.5	2.2	-0.0
Medication: Atenolol	1.2	1.5	4.8	0.3	0.2	2.2	-1.0
Medication: Levothyroxine sodium	0.2	0.4	1.4	-1.2	0.1	0.2	0.4
Sitting height	0.0	0.3	0.4	-0.6	-0.6	-0.6	0.4
Chronic bronchitis/emphysema (father)	1.0	1.2	3.8	0.4	1.9	0.5	0.7
High blood pressure (mother)	1.2	1.7	6.0	0.9	-0.2	2.5	0.2
Body mass index (BMI)	0.2	1.0	3.0	-0.4	-1.7	0.1	-1.0
Impedance of leg (left)	0.3	1.6	2.7	1.4	1.3	0.5	1.6
Leg predicted mass (left)	0.4	2.1	3.1	-0.9	-1.6	-1.8	-1.4
Trunk fat mass	0.8	3.5	10.3	-0.3	-3.2	-1.1	-1.6
Waist circumference	0.9	3.2	7.3	-1.1	-2.7	-1.4	-1.5
Number of incorrect matches in round	0.8	1.4	3.2	-1.0	1.0	0.6	-1.8
Past tobacco smoking	1.2	2.3	4.0	1.3	2.0	1.8	-0.3
Alcohol usually taken with meals	1.0	1.6	4.0	1.5	2.0	-0.0	-0.3
Nervous feelings	1.0	1.8	6.5	-0.3	0.4	2.6	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.6	-0.6	-0.4	2.1	0.7
Hearing difficulty/problems with background noise	0.3	0.5	1.3	-1.1	-0.6	-0.4	-0.6
Hair/balding pattern: Pattern 2	1.7	2.1	4.0	-1.5	-1.4	2.0	0.6
Had menopause	1.2	1.5	2.8	-1.7	-0.9	0.0	-1.5
Had other major operations	1.8	2.2	4.3	1.0	1.3	1.3	-2.1
Forced vital capacity (FVC)	0.3	1.0	3.1	-0.1	1.8	-0.2	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	2.5	-0.0	-0.8	1.6	0.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.6	1.6	0.4	1.3	0.1
Qualifications: None of the above	0.7	1.5	2.6	-1.2	-0.1	-1.4	-1.6
Financial difficulties in last 2 years	0.3	0.4	1.6	1.3	-0.2	0.0	0.2
Mouth/teeth dental problems	0.9	1.4	2.5	1.3	1.6	-1.2	0.2
Heart attack	1.2	1.5	4.8	2.2	-0.3	0.9	0.6
Allergy	1.3	2.9	5.7	1.7	-1.7	-2.4	-0.6
Pain all over the body in last month	1.7	1.9	4.2	-2.1	1.0	-1.5	0.2
Diabetes (self-reported)	0.3	0.4	1.0	0.1	1.0	0.6	-0.6
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	6.2	-1.1	1.9	2.5	-0.7
Medication: Ramipril	1.9	2.4	7.0	1.1	-1.1	0.6	-2.6
Medication: Simvastatin	0.7	1.0	2.3	0.6	-0.0	1.5	-1.2
Fluid intelligence score	0.3	0.6	1.3	1.1	-0.0	1.0	-0.1
Illnesses of siblings	0.7	0.9	3.3	1.8	-0.0	0.7	0.1
Neuroticism score	1.5	3.1	11.4	-0.2	-0.6	3.4	-0.7
Weight	0.5	2.4	5.2	-0.7	-2.3	-1.5	-1.3
Impedance of arm (right)	0.5	2.3	6.2	2.5	-1.4	0.3	1.1
Arm fat percentage (right)	0.7	2.9	9.7	0.9	-3.1	-0.1	-1.1
Trunk fat-free mass	0.2	1.4	3.2	-1.2	-0.7	-1.8	-0.7
Hip circumference	0.7	3.2	8.4	-0.4	-2.9	-1.6	-1.4
Time employed in main current job	1.7	2.0	4.1	-0.1	-2.0	1.8	-0.6
Alcohol intake versus 10 years previously	0.5	0.7	1.5	-0.7	-1.2	-0.2	0.8
Father’s age at death	1.3	1.8	4.6	2.1	1.4	0.1	0.8
Worrier / anxious feelings	1.1	2.1	5.5	-1.4	-0.3	2.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.7	-0.8	-0.6	2.6	-0.9
Falls in the last year	1.2	1.6	3.3	-1.8	-1.1	-0.7	-1.2
Hair/balding pattern: Pattern 3	0.9	1.3	4.1	0.3	2.0	0.1	-1.1
Number of live births	0.5	0.7	2.0	-0.2	0.8	0.3	1.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.7	0.6	1.6	0.0	0.7
Pulse rate	0.5	0.8	1.1	-1.1	0.8	-0.7	-1.0
Happiness	0.8	0.9	2.2	0.2	0.1	1.3	-1.5
Noisy workplace	1.1	1.3	2.6	0.2	0.5	1.5	1.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.9	1.1	0.9	1.4	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.4	-1.0	1.2	0.0	-0.7
Mouth/teeth dental problems: Dentures	0.8	1.3	2.2	-1.4	-1.5	-0.9	0.6
Asthma	0.9	1.8	4.1	-1.4	-0.1	1.1	-2.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.3	1.1	-1.5	-0.4	0.1
Medication: Cholesterol lowering	0.7	1.1	2.8	0.5	1.7	0.6	-1.0
Depression (self-reported)	0.0	0.1	0.1	0.2	0.2	0.3	0.2
Medication: Lansoprazole	0.6	0.6	1.6	-0.6	1.3	0.6	0.4
Prospective memory result	1.1	1.3	3.7	-0.2	0.2	-1.9	-1.2
Lung cancer (father)	0.3	0.3	0.5	0.5	-0.7	-0.2	0.7
Illnesses of mother	1.6	2.0	6.6	0.9	-0.5	-2.6	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.7	0.6	2.2	0.2	0.7
Pulse wave Arterial Stiffness index	1.8	2.2	4.6	-0.9	-2.1	-0.8	-1.6
Impedance of arm (left)	0.3	1.6	3.3	1.8	-1.6	-0.2	0.6
Arm fat mass (right)	0.5	2.0	6.8	0.1	-2.6	-0.6	-1.0
Trunk predicted mass	0.3	1.6	3.7	-1.3	-0.6	-1.9	-0.7
Standing height	0.5	4.5	13.2	-1.3	-1.6	-3.6	-0.8
Length of working week for main job	0.7	0.8	2.0	1.1	-1.4	-0.2	-0.1
Exposure to tobacco smoke at home	0.3	0.3	1.2	-0.0	0.3	-0.1	1.1
Breastfed as a baby	0.6	0.8	2.7	-1.6	-0.1	0.6	-0.1
Tense / ‘highly strung’	2.3	3.8	11.0	-1.2	1.1	3.3	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.8	0.1	-0.4	-0.2	-0.9
Hair/balding pattern: Pattern 4	1.4	3.4	6.6	-2.4	-1.1	-2.6	0.3
Birth weight of first child	0.0	0.1	0.3	0.2	0.5	0.1	0.2
Peak expiratory flow (PEF)	0.7	1.7	6.6	2.6	0.3	0.4	0.3
Pulse wave reflection index	1.3	1.6	4.8	-0.9	-2.2	0.7	0.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.9	0.7	0.3	0.8	1.4
Loud music exposure frequency	1.1	1.2	3.0	0.8	-1.1	-0.2	-1.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.8	0.9	0.5	0.1	0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-0.5	0.3	0.9	-1.4
Blood clot in the leg (DVT)	0.7	0.9	2.6	-0.3	-0.6	-0.8	-1.6
Medication: Paracetamol	2.0	3.3	12.0	-1.0	-3.5	-0.2	0.3
Headache pain in last month	1.7	3.0	6.0	-0.8	-2.4	1.5	1.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	-0.6	-1.0	-0.9	0.8
Glaucoma (self-reported)	0.4	0.4	1.1	-0.1	1.0	-0.7	0.2
Gout (self-reported)	0.8	1.0	2.8	-0.9	-0.6	-1.7	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.6	-0.5	0.3	0.3	0.8
Medication: Amlodipine	0.6	0.8	2.8	-0.3	1.7	-0.0	-0.4
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	-1.0	-0.1	1.0	-0.7
Birth weight	0.7	1.5	5.4	2.3	-0.8	0.2	0.0
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.9	-1.4	-0.5	0.9	0.5
High blood pressure (siblings)	0.3	0.5	0.8	-0.8	0.7	-0.9	-0.2
Forced vital capacity (FVC), Best measure	0.4	1.4	5.4	-0.1	2.3	-0.2	0.4
Body fat percentage	0.7	2.7	8.9	0.2	-3.0	-0.3	-1.3
Leg fat percentage (right)	0.4	1.6	3.8	0.2	-1.9	0.2	-1.5
Arm fat-free mass (right)	0.4	2.3	3.8	-2.0	-0.7	-1.9	-1.2
Exposure to tobacco smoke outside home	1.1	1.4	5.3	0.2	0.6	-2.3	-0.2
Comparative body size at age 10	0.7	1.9	3.4	-1.9	0.6	0.7	1.8
Number of full brothers	1.0	1.3	4.2	0.7	-0.5	0.2	2.1
Worry too long after embarrassment	2.2	3.7	8.5	0.8	2.3	2.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.2	0.2	-0.7	0.1
Wheeze or whistling in the chest in last year	0.6	1.1	2.1	-0.7	-1.4	0.7	-1.2
Number of children fathered	0.8	0.9	3.4	-0.1	-0.2	-1.8	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	2.4	2.9	5.7	-1.9	-0.9	-1.1	-2.4
Age at first live birth	1.2	2.1	4.2	1.4	2.0	0.9	-1.1
Pulse wave peak to peak time	1.3	1.6	3.7	0.9	1.9	0.3	1.3
Health satisfaction	0.8	1.1	1.9	-0.7	-0.9	1.0	-1.4
Shortness of breath walking on level ground	1.5	1.8	4.3	-0.6	-1.4	0.7	-2.1
Qualifications: College or University degree	0.4	1.3	3.3	-0.9	1.8	0.6	-0.9
Eye problems/disorders: None of the above	0.6	0.7	2.2	1.5	-0.5	0.4	0.4
Mouth/teeth dental problems: Loose teeth	2.0	2.3	5.8	-0.5	-2.4	-0.8	-1.6
Emphysema/chronic bronchitis	1.2	1.3	3.1	-0.0	-0.4	1.8	1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	3.2	1.1	1.8	0.5	0.4
Neck or shoulder pain in last month	0.3	0.4	1.2	0.3	-1.1	-0.3	-0.3
Medication: Blood pressure	0.2	0.4	0.8	0.1	0.9	0.3	-0.9
Angina (self-reported)	0.2	0.2	0.6	0.3	0.3	-0.4	-0.8
Migraine (self-reported)	0.9	1.2	2.2	1.5	-0.5	-0.4	1.4
Medication: Ibuprofen	0.7	0.9	2.0	0.8	-1.4	-0.7	0.6
Medication: Allopurinol	1.6	2.2	5.2	-1.8	-0.6	-2.3	0.1
Medication: Omeprazole	0.5	0.6	1.6	-0.7	0.0	-1.3	-0.5
Medication: Seretide 50 evohaler	0.3	0.4	1.1	-1.1	-0.0	-0.3	-0.4
Mean time to correctly identify matches	0.4	0.7	2.7	-1.6	-0.3	-0.3	0.1
Heart disease (mother)	1.3	1.6	3.4	-1.4	-1.0	0.4	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.8	-0.2	-1.7	-0.0	0.9
Whole body fat mass	0.7	2.8	7.8	-0.4	-2.8	-1.1	-1.4
Leg fat mass (right)	0.4	1.6	3.6	-0.2	-1.9	-0.6	-1.6
Arm predicted mass (right)	0.4	2.3	4.0	-1.8	-0.4	-2.0	-1.3
Pulse rate, automated reading	0.6	2.0	5.3	-1.6	0.2	-0.5	-2.3
Alcohol intake frequency.	0.3	0.8	1.5	-0.5	-1.2	0.8	0.8
Comparative height size at age 10	0.3	1.9	3.3	-1.5	-1.8	-0.1	-1.5
Number of full sisters	0.7	0.9	1.8	1.3	0.6	-1.1	-0.3
Suffer from ‘nerves’	0.7	1.1	2.2	-0.4	0.7	1.5	-1.3
Overall health rating	1.6	3.4	6.2	-0.5	-2.5	2.3	-1.5
Chest pain or discomfort	1.6	2.4	5.0	-0.1	-2.0	-0.7	-2.2
Had major operations	1.3	1.5	2.5	-1.5	1.6	1.1	0.5
Age at last live birth	1.7	2.5	5.9	2.0	2.4	0.2	-0.1
Family relationship satisfaction	0.9	1.2	2.0	-0.8	1.4	0.6	-1.2
Leg pain on walking	1.1	1.3	2.3	-1.5	-1.5	-0.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	3.0	0.7	-0.4	1.7	1.5
Commuting to job workplace: Car/motor vehicle	2.4	2.8	8.2	1.3	1.2	2.9	0.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.1	-0.2	-1.1	-1.0	-0.1
Medication: Aspirin	0.5	0.7	1.7	-1.3	0.1	-0.9	-0.1
Supplements: Vitamin C	1.4	1.7	3.8	-2.0	1.5	-0.6	0.7
Knee pain experienced in last month	0.8	1.2	1.7	-1.3	-1.3	1.2	-0.3
Hypertension (Self-reported)	0.7	2.0	4.1	-1.7	1.0	0.5	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.4	0.8	-0.5	-0.5
Illnesses of father: Heart disease	0.3	0.4	0.8	0.5	0.4	-0.9	0.6
Illnesses of siblings: Diabetes	0.5	0.6	1.1	-0.7	-0.8	1.0	-0.5
Smoking status: Previous	1.3	1.9	3.8	-1.3	-1.9	-1.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.1	1.4	0.8	-0.8	0.9
Whole body fat-free mass	0.3	2.0	3.8	-1.3	-1.2	-1.9	-1.0
Leg fat-free mass (right)	0.4	2.4	4.0	-1.0	-1.6	-2.0	-1.4
Arm fat percentage (left)	0.7	2.7	8.9	0.7	-3.0	-0.2	-1.2
Average weekly red wine intake	0.2	0.3	0.9	0.5	0.9	0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.4	1.2	-0.4	-0.2	1.1	-0.7
Mood swings	0.6	1.1	3.7	0.9	0.1	1.9	0.0
Loneliness, isolation	1.4	1.9	4.0	-1.2	-1.5	2.0	-0.5
Long-standing illness, disability or infirmity	1.1	1.7	3.4	-0.9	-0.3	1.9	-1.6
Ever had bowel cancer screening	1.3	1.5	5.5	-0.3	-2.4	-0.7	-0.1
Diabetes diagnosed by doctor	0.5	0.8	1.6	0.3	1.3	1.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	-1.0	-0.5	0.1	1.0
Friendships satisfaction	1.1	1.3	4.9	-0.0	-0.6	2.2	-0.1
Qualifications: nursing, teaching	0.8	1.3	2.9	1.1	1.7	0.9	0.3
Commuting to job workplace: Walk	0.9	1.0	2.1	0.7	1.0	0.5	1.4
Eye problems/disorders: Cataract	0.6	0.7	1.5	-1.2	0.3	1.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	3.8	0.3	0.4	1.9	0.2
Medication for cholesterol	1.5	2.3	5.1	0.2	-0.9	-1.8	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	7.3	-0.1	2.7	1.3	0.6
Back pain experienced in last month	1.2	1.7	5.8	-0.7	-2.4	0.6	-0.4
Mineral and other dietary supplements	1.1	1.5	4.6	1.0	0.6	-2.1	-0.2
Breast cancer (self-reported)	2.3	2.7	9.2	0.2	0.9	-0.8	-3.0
Asthma (self-reported)	0.9	1.8	3.6	-1.5	-0.0	1.2	-1.9
Osteoporosis (self-reported)	0.7	0.8	2.5	-0.9	0.1	1.6	-0.0
Osteoarthritis (self-reported)	0.4	0.5	1.0	-0.1	-0.8	1.0	-0.7
Medication: Aspirin	0.5	0.6	2.1	-1.5	0.2	-0.7	-0.1
Medication: Gliclazide	0.1	0.1	0.3	0.6	0.2	-0.4	-0.2
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	-0.5	-0.9	0.6	0.2
Smoking status: Current	0.9	1.4	3.7	-0.3	-1.3	-1.9	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	7.8	-0.1	2.8	-0.4	-0.4
Whole body water mass	0.3	1.9	3.6	-1.3	-1.1	-1.9	-1.0
Leg predicted mass (right)	0.5	2.4	4.2	-1.0	-1.6	-2.1	-1.4
Arm fat mass (left)	0.5	2.1	6.7	-0.2	-2.6	-0.8	-1.0
Number of self-reported non-cancer illnesses	2.3	4.0	7.5	-1.4	1.2	2.7	-2.2
Average weekly champagne plus white wine intake	0.3	0.4	1.2	1.1	-0.1	-0.1	-0.4
Miserableness	1.0	1.7	3.6	1.9	-0.9	1.6	0.2
Guilty feelings	1.1	1.7	6.2	-0.4	0.4	2.5	0.3
Wears glasses or contact lenses	1.9	2.2	4.3	-2.1	-0.7	0.4	-1.9
Ever taken oral contraceptive pill	1.7	1.9	3.3	-1.6	0.1	-1.4	1.8
Hearing aid user	0.4	0.4	0.6	0.8	0.2	0.8	0.6
Mother’s age at death	0.5	0.6	0.9	-0.7	-0.8	-0.7	-0.9
Financial situation satisfaction	0.2	0.3	0.9	1.0	-0.2	0.3	0.2
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.7	0.3	0.8	0.9
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.4	-0.1	-0.5	0.3
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	0.1	-0.2	-0.7	0.2
Medication: Blood pressure	1.5	2.9	8.8	-1.4	-0.6	0.8	-3.0
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.0	0.3	-0.5	-1.4	-0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.7	-1.3	0.0	0.8	-0.1
High cholesterol (Self-reported)	0.9	1.6	4.4	0.1	0.3	1.4	-2.1
Medication: Bendroflumethiazide	3.1	4.7	17.0	-0.8	-1.0	0.5	-4.1
Medication: Paracetamol	2.3	3.6	12.5	-1.2	-3.5	0.1	0.5
Medication: Lisinopril	0.2	0.3	0.6	0.1	0.8	0.5	0.4
Medication: Atorvastatin	0.5	0.6	1.5	1.2	0.9	0.1	-0.4
Illnesses of father: High blood pressure	1.1	1.4	3.9	0.1	1.3	0.2	-2.0
Alcohol drinker status: Never	0.8	0.9	2.1	-0.6	-1.5	1.1	0.0
Ever smoked	1.2	2.1	5.3	-1.0	-1.3	-2.3	0.8
Basal metabolic rate	0.3	1.8	3.3	-1.0	-1.4	-1.8	-1.0
Leg fat percentage (left)	0.4	1.3	2.9	0.1	-1.7	0.0	-1.5
Arm fat-free mass (left)	0.3	1.5	2.9	-1.3	-0.6	-1.7	-1.0
Number of operations (self-reported)	2.2	3.2	8.8	0.0	1.8	3.0	0.8
Average weekly beer plus cider intake	1.5	2.2	6.1	-1.4	-0.6	0.6	2.5
Irritability	0.2	0.3	0.8	-0.6	-0.1	0.9	-0.2
Risk taking	0.7	1.0	2.5	-0.7	-1.6	-0.1	1.1
Ever had prostate specific antigen (PSA) test	3.8	4.3	6.3	-2.4	-2.5	-1.4	-1.8
Fractured/broken bones in last 5 years	0.4	0.5	0.9	0.8	-0.5	1.0	0.2
Age started oral contraceptive pill	2.2	2.8	7.5	-0.5	-1.7	-0.8	-2.7
Diastolic blood pressure, automated reading	0.2	0.6	1.0	-0.4	0.2	1.0	-1.0
Ever depressed for a whole week	1.7	2.1	5.2	2.3	-0.2	1.5	1.0
Unable to work because of sickness or disability	1.1	1.4	2.1	1.4	-0.7	1.1	-1.4
Commuting to job workplace: Cycle	0.6	0.7	2.8	-0.2	0.2	-0.3	-1.7
Myopia	1.4	2.1	4.5	-1.5	-0.8	1.0	-2.1
Vascular/heart problems diagnosed by doctor	1.0	2.6	4.8	1.5	-1.0	-1.6	2.2
Cholesterol lowering medication	0.9	1.3	1.7	1.2	-0.5	1.3	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.2	-0.9	-0.7	-0.3
Pain experienced in last month	1.6	2.6	5.2	1.8	2.3	0.1	1.4
Supplements: Calcium	1.5	1.7	6.4	-2.5	-0.1	0.6	0.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.0	1.0	-0.8	0.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.2	1.8	-0.6	0.8	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.8	-0.4	-0.6	-0.7	-1.7
Heart disease (siblings)	0.3	0.4	1.4	0.2	0.1	1.2	0.0
Alcohol drinker status: Previous	3.2	3.7	13.2	1.2	0.0	3.6	0.1
Pack years of smoking	1.0	1.4	4.3	0.5	0.1	1.0	2.1
Impedance of whole body	0.2	1.1	2.9	1.7	-0.3	-0.0	1.2
Leg fat mass (left)	0.4	1.6	3.1	-0.4	-1.8	-0.9	-1.6
Arm predicted mass (left)	0.3	1.4	2.6	-1.6	-0.4	-1.4	-0.8