TWAS hub - MTSS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1926	0.0541	3.6e-04	0.006	NA	0.025	NA	0.006	1.1e-01	NA	4.1e-03	NA	9.9e-02
2	GTEx	Esophagus Muscularis	0.1460	0.0580	8.2e-03	0.068	NA	0.074	NA	0.072	6.2e-05	NA	3.0e-05	NA	3.5e-05
3	GTEx	Heart Left Ventricle	0.3510	0.0772	8.5e-06	0.255	NA	0.159	NA	0.233	7.3e-14	NA	8.3e-09	NA	1.3e-12
4	GTEx	Nerve Tibial	0.1526	0.0524	1.6e-03	0.074	NA	0.064	NA	0.069	6.5e-06	NA	2.6e-05	NA	1.2e-05
5	NTR	Blood	0.0177	0.0075	8.6e-03	0.008	0.004	0.006	0.005	0.007	1.1e-03	1.8e-02	3.7e-03	8.4e-03	2.4e-03
6	YFS	Blood	0.1192	0.0267	1.2e-13	0.036	0.052	0.062	0.076	0.052	7.1e-12	1.4e-16	1.7e-19	8.6e-24	1.9e-16
7	TCGA	Testicular Germ Cell Tumors	0.3340	0.0900	2.7e-04	0.166	0.121	0.091	NA	0.130	1.8e-06	4.8e-05	4.2e-04	NA	2.5e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Medication: Gliclazide	2.6	3.0	6.2	2.5	-1.4	-1.3	1.5	1.4	1.3	2.2
Eye problems/disorders: Diabetes related eye disease	2.3	2.5	8.6	1.6	-0.3	-2.3	0.6	-0.4	-0.2	2.9
Prospective memory result	2.2	2.7	6.6	-0.9	1.6	-2.0	0.0	2.2	2.6	0.2
Number of full sisters	2.2	2.7	6.7	-0.2	2.3	-1.6	2.6	-1.5	-1.0	0.8
Ulcerative Colitis	2.1	3.1	8.2	0.1	2.2	-0.7	2.9	-0.3	-1.2	2.6
Medication: Omeprazole	2.1	2.5	5.5	1.2	2.1	-1.2	0.9	2.4	2.0	-0.1
Breast cancer (self-reported)	2.1	2.5	7.6	-2.8	1.0	0.3	-0.3	-0.1	1.2	-2.7
Basal cell carcinoma (self-reported)	2.1	2.4	5.6	-2.4	1.2	-0.8	0.7	2.2	1.8	1.0
Medication: Ibuprofen	2.0	2.4	6.3	1.2	-1.3	-1.1	-0.8	2.5	1.9	-1.4
Ulcerative Colitis (UC)	1.9	3.6	10.8	0.2	1.9	-0.3	3.3	-0.5	-1.2	3.0
Noisy workplace	1.9	2.3	6.8	-2.6	1.4	-2.2	-0.1	0.5	1.4	-0.7
Medication for pain relief, constipation, heartburn	1.9	3.2	9.6	-1.5	-0.1	2.2	0.4	-2.2	-3.1	0.5
Pain all over the body in last month	1.8	1.9	6.8	1.2	-1.0	-0.9	1.7	-0.2	-0.5	2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	5.0	2.2	-1.8	1.2	-1.6	-1.4	-0.2	0.4
Commuting to job workplace: Walk	1.8	1.9	5.3	2.3	1.4	1.7	0.5	-1.3	1.2	0.0
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	3.2	1.5	1.6	-1.8	0.9	1.8	1.7	0.3
Maternal smoking around birth	1.7	2.5	7.7	-1.4	2.2	-2.8	1.0	-0.1	0.4	1.2
Falls in the last year	1.7	2.3	4.0	-0.3	1.8	1.5	1.6	-0.5	-2.0	-2.0
Ever highly irritable/argumentative for 2 days	1.7	2.1	3.8	0.3	1.8	-1.3	1.9	1.6	1.7	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	7.5	2.1	0.9	-0.2	2.7	0.7	0.6	0.9
Ever had hysterectomy (womb removed)	1.6	1.8	3.3	-0.7	1.5	-1.6	1.1	1.4	1.8	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.1	4.3	1.4	-1.2	-1.4	-0.5	2.1	1.9	-1.0
Number of operations (self-reported)	1.6	2.3	7.8	-0.0	2.2	-0.3	0.0	1.6	2.8	-0.9
Risk taking	1.6	2.3	9.5	-2.0	0.9	-0.5	0.6	3.1	0.9	-0.6
Supplements: Calcium	1.6	1.7	4.5	2.0	-1.3	0.6	0.1	-2.1	-1.3	-0.2
LDL Cholesterol	1.5	2.4	12.7	-0.3	3.6	-0.0	0.9	0.7	0.1	1.6
Had other major operations	1.5	1.8	10.1	0.3	1.3	-0.6	-0.3	0.7	3.2	0.0
Pulse wave Arterial Stiffness index	1.5	1.7	4.5	-0.8	-2.1	0.7	-1.2	0.1	-1.2	-1.9
Miserableness	1.5	2.7	7.7	-0.7	1.3	0.3	-1.1	2.7	2.8	0.2
Alcohol drinker status: Previous	1.5	1.8	4.5	2.1	0.5	0.0	1.6	2.1	0.2	-0.4
Neck or shoulder pain in last month	1.4	2.0	4.6	1.7	-1.3	1.4	-0.2	2.1	1.6	-0.2
Family relationship satisfaction	1.4	1.7	6.8	-0.2	1.5	-0.5	0.6	2.6	1.4	0.6
Medication: Aspirin	1.4	1.8	6.8	1.3	1.0	-2.6	1.3	0.5	1.1	-0.0
Eye problems/disorders: Glaucoma	1.4	1.7	5.2	-1.6	-0.5	0.4	-0.4	-2.3	-1.5	-1.1
Irritable Bowel Disease (IBD)	1.3	3.1	9.4	0.2	1.6	-1.3	3.1	-0.2	-0.6	2.7
Ovarian Cancer	1.3	1.8	3.9	-0.5	-1.3	0.8	-2.0	-0.9	-1.9	-1.3
HbA1C	1.3	1.4	3.4	1.5	-1.2	1.1	-1.9	-0.7	0.6	-0.8
Triglycerides	1.3	2.1	4.5	-1.0	1.7	-1.6	2.1	-0.1	-0.7	1.8
Frequency of depressed mood in last 2 weeks	1.3	1.8	6.2	1.4	0.1	1.9	2.5	0.4	0.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	9.6	-3.1	1.3	0.1	-0.7	2.3	1.4	-1.1
Father’s age at death	1.3	1.7	6.9	-0.3	-1.2	2.6	-1.2	-0.1	-0.2	-1.4
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	4.4	-2.1	1.4	-0.6	1.4	-0.7	-1.6	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.5	2.1	0.2	-1.6	1.8	-0.1	0.0	-0.5
Alcohol drinker status: Never	1.3	1.5	2.8	-0.9	-1.7	0.7	-1.6	0.3	-1.1	-1.6
Breast Cancer	1.2	2.9	6.0	-1.6	2.2	-2.1	-1.5	0.6	-0.2	-2.4
Mean Putamen Volume	1.2	1.3	4.3	0.9	0.0	2.1	0.5	0.7	-0.3	1.8
Supplements: Zinc	1.2	1.3	5.4	0.3	-1.1	2.3	-0.8	0.1	-0.5	-1.3
Past tobacco smoking	1.2	2.1	7.1	-1.7	0.0	-0.7	2.7	-0.6	-1.7	0.9
Number of children fathered	1.2	1.4	2.3	-1.0	-1.4	-1.5	-1.2	1.4	0.7	0.6
Pulse wave peak to peak time	1.2	1.4	3.9	0.8	2.0	-0.6	0.8	-0.3	1.1	1.8
Health satisfaction	1.2	1.6	4.0	1.7	1.8	0.5	2.0	0.1	0.7	-0.3
Angina (self-reported)	1.2	1.6	3.1	1.8	1.2	-1.6	0.2	-0.7	-0.8	1.7
Mood swings	1.2	2.1	8.4	-0.2	0.2	0.3	0.6	2.9	2.4	0.2
Medication: Aspirin	1.2	1.6	6.4	1.5	0.9	-2.5	0.8	0.0	0.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.4	7.0	-0.1	-0.2	-0.2	1.5	2.6	1.0	-2.6
Irritability	1.2	2.1	4.0	0.1	2.0	-1.4	1.1	2.0	1.4	1.2
Cholesterol lowering medication	1.2	1.7	5.0	1.2	1.9	-0.1	-0.1	0.7	1.2	2.2
Depression (Nagel 2018)	1.1	1.7	4.8	-0.6	1.7	1.7	2.2	0.7	0.2	0.1
Blood Platelet Count	1.1	12.3	77.3	0.5	-2.1	-8.8	-0.3	-0.8	-0.2	1.9
Angina	1.1	1.4	2.4	1.6	1.5	-1.4	0.3	-0.5	-0.6	1.6
Medication: Co-codamol	1.1	1.3	2.6	0.9	-1.0	1.1	-0.1	1.6	1.5	1.0
Hearing difficulty/problems with background noise	1.1	1.8	6.1	-0.2	0.3	0.9	0.1	2.5	1.5	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	8.3	-2.9	0.9	-0.1	-0.3	2.5	1.4	-0.9
Depression (self-reported)	1.1	1.3	4.7	-0.6	1.3	-0.5	2.2	0.8	0.7	0.9
Pulse wave reflection index	1.1	1.4	3.3	-1.8	-1.6	0.5	-0.9	0.8	-0.7	-1.3
Blood clot in the leg (DVT)	1.1	1.4	4.5	0.1	0.9	-0.9	1.2	1.3	2.1	0.7
Emphysema/chronic bronchitis	1.1	1.3	2.7	0.8	-0.5	-0.5	-1.6	1.5	1.7	-0.3
Guilty feelings	1.1	1.7	5.7	-1.0	1.2	-0.8	-0.5	1.5	2.4	0.7
Financial situation satisfaction	1.1	1.4	3.9	1.8	0.7	1.0	0.2	2.0	0.5	0.9
Neuroticism	1.0	2.4	7.5	-1.0	0.8	0.1	0.4	2.6	2.7	0.7
Diabetes (father)	1.0	1.2	2.8	-1.7	0.3	-1.4	1.6	-0.4	-0.2	0.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	2.5	-1.6	-0.8	-0.5	-1.5	0.7	-0.7	-1.6
Hair/balding pattern: Pattern 3	1.0	1.5	4.4	1.2	0.8	-0.9	2.1	1.4	0.0	0.8
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.2	0.9	-1.4	0.0	-0.5	-0.7	-1.3	-1.8
Medication: Cholesterol lowering	1.0	1.5	6.7	-0.1	1.3	-2.6	0.9	-0.7	-0.9	0.5
Illnesses of mother	1.0	1.2	5.8	0.7	1.3	-0.4	0.6	-0.3	-0.0	2.4
High blood pressure (siblings)	1.0	1.4	5.1	-0.5	-0.8	-2.3	0.2	1.2	1.1	-1.1
Age at first live birth	1.0	1.8	3.8	-1.1	-0.5	1.4	-1.6	-0.4	-1.7	-2.0
Chest pain or discomfort	1.0	1.5	3.7	-1.4	1.9	-0.4	-0.0	1.6	1.3	0.5
Commuting to job workplace: Car/motor vehicle	1.0	1.2	4.8	-2.2	1.0	-0.8	-0.1	0.7	-0.7	-0.7
Back pain experienced in last month	1.0	1.5	2.9	0.9	-0.7	1.6	-1.1	1.4	1.7	-0.8
Wears glasses or contact lenses	1.0	1.2	5.6	1.0	-2.4	-0.3	0.4	-0.2	-0.9	0.7
Medication: Atorvastatin	1.0	1.3	3.7	-1.9	0.8	-1.4	-0.1	0.3	0.2	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	3.6	-0.2	0.9	-0.6	1.3	1.2	1.9	0.8
Depressed Affect (Nagel 2018)	0.9	1.9	5.7	-0.2	0.9	1.3	-0.6	2.4	2.1	-0.4
Crohns Disease (2012)	0.9	1.4	7.9	0.2	0.2	-2.8	1.2	0.2	0.6	0.3
Type 2 Diabetes (T2D) (2012)	0.9	1.0	2.8	-1.4	1.3	-0.6	-0.2	0.7	0.2	-1.7
Waist Hip Ratio (WHR)	0.9	4.0	17.1	-1.3	2.1	-4.1	1.6	-0.7	0.0	1.4
Smoking Status	0.9	2.2	5.1	2.0	1.0	1.3	-2.3	-1.0	0.5	-1.6
Townsend deprivation index at recruitment	0.9	1.2	2.7	0.2	1.6	-1.0	1.2	-0.8	-0.9	1.4
Illnesses of siblings	0.9	1.2	5.8	-0.4	0.2	2.4	0.3	-1.2	-1.0	0.3
Neuroticism score	0.9	1.9	6.2	-0.9	0.4	0.2	-0.3	2.4	2.5	0.6
Happiness	0.9	1.1	3.4	1.0	0.5	1.8	0.3	1.5	0.7	0.4
Leg pain on walking	0.9	1.1	3.5	-0.9	1.5	0.8	0.6	-1.9	-0.5	-0.4
Friendships satisfaction	0.9	1.1	2.8	-0.6	1.0	-1.7	-0.5	1.3	1.2	-0.6
Fractured/broken bones in last 5 years	0.9	1.2	3.4	-0.8	1.2	0.2	-0.1	-1.6	-1.8	0.2
Myopia	0.9	1.2	4.7	0.8	-0.4	-2.2	0.2	-1.2	-0.8	1.0
Major Depression (MDD)	0.8	1.0	3.0	-1.7	-0.7	0.2	-0.9	0.9	1.3	0.3
Bipolar Disorder (2011)	0.8	0.8	2.8	-0.6	0.5	0.3	0.6	0.2	-1.3	-1.7
Neuroticism (2016)	0.8	1.1	2.1	-1.4	1.2	0.9	1.4	-0.0	0.9	-0.8
Allergy or Eczema	0.8	2.0	6.2	-0.2	2.5	-1.0	0.7	1.2	0.4	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.6	-0.7	1.6	1.1	1.6	0.8	0.4	0.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	3.3	0.1	0.3	0.5	1.3	0.6	1.8	-0.2
Number of incorrect matches in round	0.8	1.4	4.3	-0.8	0.4	0.6	-1.9	-0.4	0.5	-2.1
Exposure to tobacco smoke at home	0.8	0.9	2.7	1.6	-0.6	0.0	-1.3	-0.4	-1.2	0.3
Comparative body size at age 10	0.8	2.2	7.1	-1.3	-1.3	-1.7	1.1	-0.8	0.0	-2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.0	-0.3	1.7	0.9	0.7	-1.6	-0.6	0.1
Eye problems/disorders: None of the above	0.8	0.9	4.0	0.9	0.0	0.0	1.0	0.6	-0.2	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	-1.1	-0.9	0.7	-0.5	-0.9	-1.7	-0.4
Smoking status: Previous	0.8	1.2	5.3	1.0	0.3	0.1	-2.3	0.3	1.3	-0.6
Diabetes diagnosed by doctor	0.8	1.3	2.4	1.3	1.2	-1.5	1.3	-0.5	-0.0	1.4
Ever taken oral contraceptive pill	0.8	0.9	2.6	0.0	-0.3	1.0	0.5	-1.6	-1.5	0.5
Mother’s age at death	0.8	1.0	3.1	-0.1	1.1	0.7	1.1	-0.8	0.6	-1.8
Supplements: Fish oil (including cod liver oil)	0.8	1.1	3.3	1.4	0.0	1.8	1.1	-0.3	-0.2	0.8
Medication: Paracetamol	0.8	1.3	3.2	0.3	-1.4	-0.2	-1.8	0.6	1.2	-1.4
Illnesses of father: High blood pressure	0.8	1.0	4.1	-0.3	1.0	0.2	2.0	-0.6	-0.5	0.9
Ever smoked	0.8	1.5	4.0	2.0	-0.5	0.3	-1.7	0.5	1.6	-0.5
Schizophrenia (2018)	0.7	1.5	6.6	-0.8	0.2	-0.7	-1.2	0.1	1.3	-2.6
Schizophrenia vs Biploar Disorder	0.7	1.0	3.3	0.2	-0.9	0.1	-1.1	-0.9	-0.8	-1.8
Alzheimer’s Disease (including proxy)	0.7	1.0	3.2	0.6	-0.9	-0.1	-0.4	-1.6	-1.8	0.2
Body Mass Index (BMI) (2010)	0.7	0.9	1.6	1.2	-0.5	0.7	-1.2	1.3	0.8	-0.5
Cardiovascular Disease	0.7	2.3	6.2	-0.9	1.3	-2.5	2.0	-1.1	-0.7	1.2
Chronotype (morning person)	0.7	1.5	2.7	-1.6	-0.5	-0.1	1.2	-1.4	-1.3	-1.6
Number of treatments/medications taken	0.7	1.3	3.8	1.2	0.4	-0.4	0.9	1.9	1.6	0.0
Hearing difficulty/problems: Yes	0.7	1.1	2.6	0.1	-0.5	0.2	1.4	1.6	0.9	1.4
Medication for hormone replacement therapy	0.7	0.8	2.1	-1.3	0.9	0.1	0.1	1.5	0.5	-0.7
Average weekly fortified wine intake	0.7	0.9	2.2	-1.5	1.0	1.2	0.4	-1.1	-0.6	-0.1
Relative age voice broke	0.7	1.1	2.7	-1.7	-0.3	-0.8	-1.6	-0.8	0.7	-0.9
Stomach or abdominal pain in last month	0.7	0.9	2.7	1.4	0.8	-0.2	1.6	-0.0	1.0	0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	3.0	-0.6	0.4	0.3	-0.4	1.1	0.8	-1.7
High blood pressure (mother)	0.7	1.0	3.5	0.7	-1.9	-0.5	-0.5	0.3	1.2	-0.9
Medication: Simvastatin	0.7	1.0	1.6	1.3	-0.1	-1.3	-0.6	-1.1	-1.0	1.1
Impedance of arm (right)	0.7	3.2	9.6	0.2	0.6	3.1	-1.9	-1.3	-1.7	-2.1
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	4.2	-0.1	-0.9	1.6	-2.0	0.6	-0.3	-0.0
Shortness of breath walking on level ground	0.7	0.8	1.6	1.2	0.6	-1.0	1.0	0.1	0.7	-1.2
Medication: Blood pressure	0.7	1.2	4.0	0.1	1.1	-1.2	2.0	-0.3	1.2	0.4
Heart disease (mother)	0.7	0.8	1.4	-1.1	0.0	0.5	-0.3	1.1	1.1	-1.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.7	0.6	0.8	1.0	1.6	0.9	0.7	-0.1
Pain experienced in last month	0.7	1.1	3.7	-0.8	0.0	-1.3	-1.9	-0.5	-1.0	-0.8
Reaction Time	0.6	1.1	3.7	0.4	1.4	-0.5	0.7	1.9	0.8	0.2
Blood Eosinophil Count	0.6	4.7	9.1	-2.9	0.3	-3.0	2.1	-2.9	-1.4	0.4
Blood Red Count	0.6	5.6	21.0	0.5	-2.7	4.6	-0.7	-1.8	-2.2	-1.4
Respiratory disease	0.6	1.4	4.4	-0.9	0.9	-0.8	-0.2	1.5	0.7	2.1
Hand grip strength (left)	0.6	1.7	10.2	-3.2	-0.5	-0.2	-0.0	0.2	-0.5	1.1
Relative age of first facial hair	0.6	1.2	4.4	-0.7	0.4	-0.2	-1.5	-0.9	-0.6	-2.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	3.3	-0.4	0.1	-1.8	1.0	0.4	0.6	-0.6
Systolic blood pressure, automated reading	0.6	1.7	3.3	1.7	-1.8	-0.6	0.6	0.6	1.8	1.1
Diabetes (mother)	0.6	0.8	2.3	-0.6	-0.9	-1.5	0.8	1.1	0.4	-0.0
Current tobacco smoking	0.6	0.9	2.0	0.6	1.0	1.1	-0.7	0.2	1.2	-1.4
Supplements: Glucosamine	0.6	0.8	2.7	-0.6	1.6	0.8	-1.3	-0.5	0.4	-0.0
Medication: Atenolol	0.6	0.8	2.6	1.1	0.2	-0.3	1.0	-0.8	0.0	1.6
Medication: Levothyroxine sodium	0.6	1.0	3.1	0.3	0.2	-1.2	0.8	1.7	1.2	0.2
Alcohol usually taken with meals	0.6	0.9	5.1	0.0	-2.2	-0.7	-0.0	0.8	0.0	-0.3
Had menopause	0.6	0.7	2.2	1.5	0.0	-1.2	-0.2	0.9	0.9	-0.3
Mouth/teeth dental problems	0.6	0.9	2.7	0.3	-1.2	-0.6	-0.9	0.6	1.7	0.2
Fluid intelligence score	0.6	1.3	3.6	-1.1	-1.5	0.7	-0.7	0.0	-1.9	1.0
Pulse rate	0.6	1.0	3.9	0.1	0.8	-1.4	0.8	-0.1	-0.0	2.0
Impedance of arm (left)	0.6	3.0	7.8	0.3	0.5	2.8	-2.0	-1.4	-1.7	-2.0
Medication: Paracetamol	0.6	1.0	3.1	0.9	-0.9	-0.3	-1.8	0.3	1.2	-0.5
Glaucoma (self-reported)	0.6	0.8	1.8	-1.3	0.3	0.1	-0.1	-1.3	-1.3	0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.1	-0.3	1.1	-0.9	0.8	-1.4	-0.4	0.3
Exposure to tobacco smoke outside home	0.6	0.8	4.0	-0.1	2.0	0.0	0.8	-0.0	-0.9	0.0
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.4	1.2	-0.5	-1.2	1.0	0.5	-0.4
Had major operations	0.6	0.7	2.3	-0.4	1.4	-0.2	0.5	-0.2	-0.1	-1.5
Knee pain experienced in last month	0.6	1.0	4.2	0.9	0.8	0.6	0.8	-2.0	-0.4	0.2
Average weekly red wine intake	0.6	0.9	2.7	-1.2	-0.2	0.0	0.7	1.6	1.3	-0.1
Smoking status: Current	0.6	0.9	1.8	0.8	0.4	1.2	-0.9	0.3	1.1	-1.3
Ever depressed for a whole week	0.6	0.7	1.7	0.3	1.0	-0.3	-1.3	1.3	-0.2	-0.7
Pack years of smoking	0.6	0.9	2.3	1.1	-1.2	-0.3	-1.5	0.1	-0.1	-1.0
Bipolar Disorder (2018)	0.5	0.8	3.1	-0.9	0.5	-0.6	1.8	-0.6	-0.3	0.7
Neuroticism (Nagel 2018)	0.5	1.2	3.5	-0.3	0.8	0.9	0.3	1.9	1.8	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	2.3	0.6	-1.2	-0.1	-0.0	-0.6	-1.5	0.0
Crohns Disease (2017)	0.5	1.2	3.5	-0.3	0.7	-1.9	1.7	0.6	0.6	1.0
HDL Cholesterol	0.5	0.9	2.2	0.7	-1.0	1.5	-1.4	0.7	0.4	-0.2
Rheumatoid Arthritis	0.5	0.7	1.8	0.3	-0.1	1.2	-0.8	-1.4	-1.0	0.2
Schizophrenia (2014)	0.5	1.1	5.5	-1.0	-0.1	-0.3	-0.2	-1.0	0.7	-2.3
Heel T-Score	0.5	3.8	12.7	-0.8	-0.3	-0.8	-1.2	3.6	1.4	-3.0
Severe depression (siblings)	0.5	0.5	1.3	-0.9	1.2	1.0	0.4	-0.4	0.0	0.3
Pack years adult smoking proportion	0.5	0.7	2.6	0.9	-1.0	-0.4	-1.6	-0.2	-0.2	-0.6
Fed-up feelings	0.5	1.0	3.3	0.3	1.8	0.3	0.5	0.3	1.4	1.1
Serious illness, injury or assault to yourself	0.5	0.6	2.4	0.4	1.5	0.8	0.6	-0.6	0.4	-0.5
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.3	-0.1	1.5	0.3	0.6	0.8	-0.2	-0.8
Qualifications: None of the above	0.5	1.1	2.0	1.4	0.2	0.1	-1.3	-1.4	-1.2	0.7
Heart attack	0.5	0.7	2.2	1.2	-0.2	-0.1	-0.1	-0.1	-1.5	1.1
Allergy	0.5	1.1	2.3	1.3	-1.2	1.1	-0.4	-0.7	-0.4	-1.5
Diabetes (self-reported)	0.5	0.8	1.8	0.7	1.3	-1.2	1.1	-0.4	0.2	0.9
Lung cancer (father)	0.5	0.6	1.7	1.3	-0.1	-1.0	1.2	0.2	-0.3	-0.1
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.9	1.7	-1.1	0.0	-0.1	0.1	-0.6	-0.2
Wheeze or whistling in the chest in last year	0.5	1.0	3.9	-2.0	-0.4	-0.6	-1.2	-0.4	-0.8	-0.4
Medication: Allopurinol	0.5	0.6	2.6	-0.8	-1.6	0.3	-0.2	0.6	-0.3	-0.7
Medication: Seretide 50 evohaler	0.5	0.5	3.0	-0.4	-0.5	-0.6	-0.3	1.7	0.1	0.1
Mean time to correctly identify matches	0.5	1.0	3.2	0.6	0.9	-1.0	0.5	1.8	0.9	-0.5
Alcohol intake frequency.	0.5	1.3	5.1	2.3	0.1	0.3	1.2	1.2	-0.4	0.8
Suffer from ‘nerves’	0.5	0.7	2.3	-0.6	0.5	0.9	1.5	0.5	-0.4	0.9
Overall health rating	0.5	1.1	4.0	-2.0	0.9	-0.5	1.5	-0.0	0.4	0.7
Supplements: Vitamin C	0.5	0.6	2.2	-0.5	-0.4	1.0	-1.5	-0.5	0.3	-0.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.9	-0.1	1.4	-0.7	0.1	0.2	0.6	-1.3
Loneliness, isolation	0.5	0.7	2.0	0.0	0.5	0.4	1.3	0.9	1.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	1.1	-0.1	0.4	-0.5	-0.8	-0.1	-1.2
Eye problems/disorders: Cataract	0.5	0.5	1.7	-0.6	0.2	0.1	-1.3	0.1	0.1	-1.3
Medication for cholesterol	0.5	0.8	2.7	0.5	-1.6	-0.5	-0.0	-1.0	-1.2	-0.0
Asthma (self-reported)	0.5	1.0	3.3	-1.0	0.9	-0.6	-0.3	0.9	0.6	1.8
Illnesses of father: None of the above (group 1)	0.5	0.6	2.9	0.5	-0.6	-0.5	-1.7	-0.1	-0.4	-0.4
Average weekly beer plus cider intake	0.5	0.7	1.9	-0.1	-0.6	-0.2	-1.3	-0.9	-0.3	-1.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.6	0.2	-0.5	-0.6	-0.8	0.8	1.6	0.1
Alzheimer’s Disease (in father)	0.4	0.5	1.1	-0.8	-0.4	0.2	0.4	-1.0	-1.0	-0.0
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.0	-1.1	-0.7	1.0	-1.4	-0.0	-1.3	0.3
Fasting Glucose	0.4	0.5	1.1	-0.8	0.8	-1.1	0.0	-0.4	-0.5	-0.8
Primary Biliary Cirrhosis	0.4	0.5	1.4	-0.1	-0.3	1.2	-1.1	0.6	0.5	0.7
Blood White Count	0.4	3.0	6.6	-1.7	-0.3	-2.6	-1.5	-2.2	-1.7	-1.3
Lung FVC	0.4	2.2	7.3	0.9	-0.1	-2.4	2.7	1.1	-0.0	0.7
Average weekly spirits intake	0.4	0.5	1.5	0.6	0.0	1.1	-1.2	0.4	-0.3	0.6
Sensitivity / hurt feelings	0.4	0.6	1.6	0.0	-0.6	-1.3	1.0	0.5	0.8	0.5
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.7	0.7	1.3	0.1	0.5	0.8	0.9	0.1
Medication: Metformin	0.4	0.6	1.0	0.9	0.7	-0.9	1.0	-0.5	0.7	0.6
Trunk fat percentage	0.4	1.7	5.0	0.3	-1.5	1.1	-1.2	1.4	-0.4	-2.2
Hand grip strength (right)	0.4	1.1	6.3	-2.5	-0.6	0.7	0.1	0.6	-0.4	0.5
Taking other prescription medications	0.4	0.7	2.5	0.9	0.2	1.6	1.0	0.4	0.3	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-1.1	0.1	0.7	-1.0	0.2	0.7	-0.1
Asthma	0.4	0.7	2.4	-1.0	0.8	-0.7	-0.3	0.5	0.4	1.6
Medication: Lansoprazole	0.4	0.5	1.7	-0.7	-1.3	0.1	0.6	0.3	-0.4	0.7
Peak expiratory flow (PEF)	0.4	0.9	2.6	-0.6	-0.5	0.6	1.6	-0.9	-1.1	1.0
Loud music exposure frequency	0.4	0.5	0.9	-0.3	-0.5	-0.0	0.7	-1.0	-0.8	-0.8
Migraine (self-reported)	0.4	0.5	1.8	1.3	0.7	0.4	-0.1	0.0	-0.5	0.8
Pulse rate, automated reading	0.4	1.3	2.3	-0.8	1.5	-1.2	1.3	1.4	-0.3	1.0
Age at last live birth	0.4	0.6	2.4	-0.2	0.8	0.1	-0.9	1.5	-0.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.1	-0.4	0.2	-1.0	-0.6	0.4	0.1	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	0.8	0.6	0.5	0.9	0.5	0.9	0.6	0.4
Illnesses of father: Heart disease	0.4	0.5	1.6	0.6	-1.3	0.2	1.2	-0.3	-0.1	0.2
Ever had bowel cancer screening	0.4	0.5	1.0	-0.9	1.0	0.2	0.8	0.3	0.9	0.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.0	-0.6	-0.2	-0.7	0.2	-1.4	-1.2	-0.6
Mineral and other dietary supplements	0.4	0.5	1.6	-0.6	-0.3	-1.3	-0.5	0.6	-0.4	-0.8
Osteoarthritis (self-reported)	0.4	0.6	2.5	-0.0	0.7	0.9	0.2	0.0	1.6	-0.4
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.5	-1.2	0.2	-0.0	-0.0	1.2	0.5
Age started oral contraceptive pill	0.4	0.5	1.7	-0.5	-0.3	-0.6	-1.3	-0.5	-0.4	-0.9
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.6	1.0	-0.2	-0.2	-0.2	0.1	-1.3	1.1
Heart disease (siblings)	0.4	0.5	2.2	0.3	-0.1	-0.9	-1.5	0.2	0.1	-0.7
Impedance of whole body	0.4	2.1	6.6	0.1	0.5	2.6	-1.2	-1.1	-1.3	-1.8
Bipolar Disorder or Schizophrenia	0.3	0.8	2.3	-1.2	0.5	-0.9	0.2	-0.3	0.8	-1.5
Coronary Artery Disease (CAD)	0.3	0.3	1.0	-0.4	-0.9	-0.1	-0.4	-1.0	-0.3	-0.3
Lupus	0.3	0.5	1.3	-1.1	0.5	-0.3	-0.8	0.7	0.5	0.5
Hypothyroidism (self reported)	0.3	0.7	2.0	-0.2	-0.1	-1.4	1.4	0.7	-0.0	-0.3
Vitamin and mineral supplements	0.3	0.4	1.0	0.2	0.9	-1.0	0.5	0.2	-0.5	0.5
Age when periods started (menarche)	0.3	0.7	1.7	0.7	0.6	1.3	-1.1	-0.8	-0.7	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.3	1.1	0.6	-0.2	0.4	-0.5	-0.1	0.5
Qualifications: CSEs or equivalent	0.3	0.5	1.1	1.0	-0.6	0.4	1.0	-0.1	0.1	0.8
High blood pressure	0.3	0.9	4.2	-0.7	0.6	-1.0	2.0	-0.6	-0.2	-0.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.3	-1.1	1.1	-0.6	0.4	0.4	0.3	0.9
Multivitamins +/- minerals	0.3	0.4	1.1	0.0	-1.1	1.1	-0.4	-0.2	-0.4	-0.4
Sitting height	0.3	2.2	7.0	1.3	-1.3	2.6	-2.0	1.0	0.1	-0.3
Impedance of leg (left)	0.3	1.3	4.3	-0.3	0.4	1.5	-0.5	-1.1	-1.0	-2.1
Trunk fat mass	0.3	1.5	3.6	0.3	-1.5	1.0	-1.1	1.9	-0.1	-1.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.9	1.0	1.0	-0.1	0.1	0.6	0.8	-0.0
Financial difficulties in last 2 years	0.3	0.4	1.9	0.1	0.8	-0.2	1.4	-0.1	-0.3	0.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	-0.5	-0.2	1.0	-0.6	0.0	-0.7	0.8
Medication: Ramipril	0.3	0.4	1.6	-0.0	1.2	-0.4	0.3	-0.7	-0.5	-0.1
Weight	0.3	1.3	6.0	0.2	-1.5	0.2	-0.7	2.4	0.4	-0.4
Arm fat percentage (right)	0.3	1.2	2.7	0.1	-1.7	0.6	-1.2	1.4	-0.7	-1.3
Hip circumference	0.3	1.5	4.6	0.3	-1.8	1.0	-0.5	2.1	0.2	-0.9
Time employed in main current job	0.3	0.4	0.7	-0.8	0.2	0.7	-0.8	-0.2	-0.8	0.5
Worrier / anxious feelings	0.3	0.5	2.0	0.0	-1.4	-0.6	-0.8	0.6	0.7	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.8	-0.8	-0.2	0.5	-0.7	0.7	1.3	-0.4
Qualifications: A levels/AS levels or equivalent	0.3	0.7	3.3	-0.7	-0.5	-0.8	0.1	-0.4	-1.8	-0.3
Mouth/teeth dental problems: Dentures	0.3	0.6	1.1	0.4	0.6	1.0	1.1	0.5	-0.9	0.3
Arm fat mass (right)	0.3	1.1	3.6	-0.1	-1.4	0.1	-0.9	1.9	-0.3	-0.9
Length of working week for main job	0.3	0.4	0.8	0.2	0.9	0.6	-0.5	-0.8	-0.2	-0.7
Breastfed as a baby	0.3	0.3	0.8	-0.9	-0.3	0.0	0.7	0.5	-0.3	-0.8
Tense / ‘highly strung’	0.3	0.5	1.0	-1.0	1.0	0.6	-0.7	0.4	0.4	-0.5
Gout (self-reported)	0.3	0.4	0.7	-0.8	-0.8	0.8	-0.1	0.7	-0.1	-0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.5	-0.8	-0.7	-1.1	1.2	0.7	0.3	-0.5
Medication: Amlodipine	0.3	0.4	0.9	0.2	0.5	-0.3	1.0	-0.9	-0.0	0.9
Birth weight	0.3	0.7	1.8	-0.2	-0.8	-1.0	-0.5	1.3	1.0	-0.3
Body fat percentage	0.3	1.3	3.1	0.1	-1.6	0.7	-0.9	1.5	-0.4	-1.8
Leg fat percentage (right)	0.3	1.1	4.2	-0.7	-1.4	-0.5	-0.3	2.0	0.2	-0.9
Arm fat-free mass (right)	0.3	1.3	4.0	0.5	-1.0	-0.7	0.4	2.0	1.0	1.5
Number of full brothers	0.3	0.4	1.9	0.4	-0.5	-0.7	-0.2	-0.2	-0.3	-1.4
Whole body fat mass	0.3	1.4	3.9	0.1	-1.5	0.5	-1.0	2.0	0.0	-1.5
Leg fat mass (right)	0.3	1.2	5.0	-0.5	-1.4	-0.3	-0.3	2.2	0.2	-0.8
Hypertension (Self-reported)	0.3	0.9	4.1	-0.5	0.5	-1.1	2.0	-0.7	-0.4	0.0
Illnesses of siblings: Diabetes	0.3	0.4	0.9	0.5	-0.1	-0.8	0.5	-0.9	-0.7	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.1	-0.3	0.5	1.4	0.8	-0.4	-0.7	0.3
Long-standing illness, disability or infirmity	0.3	0.5	1.5	0.2	1.0	-0.1	-0.1	0.7	1.2	0.6
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.6	-0.3	-0.7	0.9	0.2	-0.7	-0.6
Osteoporosis (self-reported)	0.3	0.3	0.8	0.6	0.6	-0.8	0.3	0.9	0.1	-0.4
Arm fat mass (left)	0.3	1.2	4.9	-0.2	-1.4	-0.0	-0.9	2.2	-0.1	-0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.5	0.2	0.8	-0.2	0.9	0.3	0.3	1.2
High cholesterol (Self-reported)	0.3	0.4	1.9	0.3	1.4	-0.4	-0.3	0.4	0.8	-0.1
Medication: Lisinopril	0.3	0.4	1.9	-0.2	-0.2	0.4	-0.2	-0.5	0.7	-1.4
Arm fat-free mass (left)	0.3	1.3	5.6	0.2	-1.2	-0.5	-0.1	2.4	1.0	0.9
Diastolic blood pressure, automated reading	0.3	0.9	3.0	-0.1	-1.7	-1.1	0.6	0.2	1.1	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.7	0.6	-0.6	1.3	-1.6	0.7	0.6	-0.0
Arm predicted mass (left)	0.3	1.3	6.0	0.0	-1.1	-0.2	0.1	2.4	0.9	1.0
Intelligence (Savage-Jansen 2018)	0.2	0.8	1.2	-1.1	0.8	0.6	-0.9	0.9	-1.1	0.6
Worry (Nagel 2018)	0.2	0.4	0.9	-0.7	0.0	0.6	0.4	0.9	0.8	0.4
Age at First Birth	0.2	0.3	0.9	-0.1	0.8	-0.2	0.6	0.1	-0.1	-1.0
Systolic Blood Pressure	0.2	1.1	2.6	0.0	-1.6	-1.4	0.0	-0.7	1.4	1.0
Lung FEV1/FVC ratio	0.2	1.2	2.3	0.5	-1.3	-0.5	1.5	1.3	-1.4	0.7
Impedance of leg (right)	0.2	1.2	4.6	-0.7	0.3	1.6	-0.7	-0.2	-0.4	-2.2
Leg fat-free mass (left)	0.2	1.0	3.7	0.3	-1.4	0.0	-0.6	1.9	0.7	0.4
Body mass index (BMI)	0.2	0.9	3.5	-0.3	-1.3	-0.9	-0.1	1.9	0.3	-0.4
Leg predicted mass (left)	0.2	0.9	3.5	0.2	-1.3	0.1	-0.6	1.9	0.6	0.6
Waist circumference	0.2	0.6	2.1	-0.3	-0.2	-1.2	0.7	1.4	0.2	0.2
Trunk fat-free mass	0.2	0.9	4.2	-0.1	-0.9	-0.2	-0.4	2.0	0.8	1.0
Alcohol intake versus 10 years previously	0.2	0.3	1.6	0.0	0.2	-0.3	1.3	-0.4	-0.8	0.0
Number of live births	0.2	0.3	0.9	0.6	0.9	-0.2	-0.1	-0.4	0.3	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.9	0.4	-0.9	-0.3	0.8	1.7	0.4	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.3	0.1	-0.9	-0.1	0.5	1.5	-0.0	-0.4
Trunk predicted mass	0.2	0.9	4.0	-0.1	-0.9	-0.1	-0.4	2.0	0.7	0.8
Standing height	0.2	1.6	5.3	0.8	-0.7	2.3	-1.5	1.5	0.4	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	-0.7	0.0	0.1	1.1	0.2	0.5	0.7
Hair/balding pattern: Pattern 4	0.2	0.6	2.9	-0.6	-0.7	0.0	-0.7	-0.0	-1.7	-0.1
Headache pain in last month	0.2	0.3	1.6	0.0	0.1	1.3	-0.4	-0.4	0.1	-0.3
Worry too long after embarrassment	0.2	0.4	1.0	-0.9	-0.5	0.2	-0.2	0.5	1.0	0.3
Qualifications: College or University degree	0.2	0.8	2.1	-1.2	0.6	-1.4	-0.7	-0.4	0.3	-0.8
Arm predicted mass (right)	0.2	1.3	4.5	0.1	-1.3	-0.6	0.3	2.1	0.8	1.3
Whole body fat-free mass	0.2	1.1	4.2	0.1	-1.1	-0.3	-0.3	2.1	0.8	1.0
Arm fat percentage (left)	0.2	0.9	2.2	0.2	-1.5	0.2	-0.9	1.4	-0.6	-1.0
Whole body water mass	0.2	1.0	4.3	0.2	-1.1	-0.2	-0.4	2.1	0.8	0.9
Average weekly champagne plus white wine intake	0.2	0.2	0.7	-0.2	-0.4	-0.1	0.1	0.8	0.5	0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	1.4	0.5	-0.1	1.2	0.2	-0.1	0.1	-0.1
Basal metabolic rate	0.2	1.0	4.6	0.0	-1.2	-0.1	-0.5	2.1	0.7	0.5
Leg fat percentage (left)	0.2	0.7	2.0	-0.4	-1.4	-0.5	-0.4	1.4	-0.2	-0.9
Unable to work because of sickness or disability	0.2	0.2	0.6	0.8	0.6	-0.0	0.5	-0.3	-0.1	-0.3
Commuting to job workplace: Cycle	0.2	0.2	0.5	0.3	0.4	-0.5	0.7	0.5	-0.5	0.4
Leg fat mass (left)	0.2	0.8	3.1	-0.3	-1.4	-0.3	-0.3	1.8	-0.1	-0.7
Prostate Cancer	0.1	0.2	0.7	0.3	-0.5	0.0	-0.8	-0.3	0.5	0.0
Height	0.1	2.9	9.7	2.1	-1.2	3.1	-0.5	1.9	0.5	0.3
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.8	0.2	0.9	-0.5	0.7	-0.5	0.1	-0.0
Hair Pigment	0.1	2.0	5.7	-1.6	1.0	-2.4	0.0	0.3	0.3	2.1
Nervous feelings	0.1	0.2	0.7	-0.6	0.1	-0.0	-0.2	-0.8	0.0	-0.4
Forced vital capacity (FVC)	0.1	0.4	1.4	0.7	-0.5	-0.0	0.8	1.2	0.6	0.2
Birth weight of first child	0.1	0.3	0.6	-0.3	-0.7	0.7	0.4	0.2	0.8	-0.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	-0.2	0.3	-0.1	-0.5	0.2	0.4	-0.7
Forced vital capacity (FVC), Best measure	0.1	0.3	1.0	0.4	-0.6	0.4	0.2	1.0	0.3	-0.5
Comparative height size at age 10	0.1	0.7	2.9	0.7	-1.0	1.7	-0.2	0.8	0.0	-0.0
Leg fat-free mass (right)	0.1	0.7	2.0	0.5	-1.2	-0.1	-0.4	1.4	0.4	0.9
Leg predicted mass (right)	0.1	0.7	2.3	0.5	-1.1	-0.1	-0.4	1.5	0.4	0.9
Hearing aid user	0.1	0.2	0.6	-0.1	-0.4	-0.1	0.4	0.4	-0.8	-0.3
Medication: Blood pressure	0.1	0.2	0.6	-0.0	-0.2	0.7	0.3	-0.1	0.8	-0.6
Medication: Bendroflumethiazide	0.1	0.1	0.5	0.1	-0.7	-0.3	0.2	0.2	0.3	-0.3
BMI	0.0	0.3	0.7	-0.7	-0.3	-0.2	-0.2	0.6	-0.4	-0.8
Tanning	0.0	0.5	1.0	0.8	-0.8	-0.0	-1.0	0.9	0.5	-0.0

Hub : Genes

MTSS1

Models

Trait associations