Hub : Genes

MTTP

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0846	0.0280	0.00019	0.033	0.034	0.034	0.041	0.040	3.5e-05	3.1e-05	2.9e-05	4.6e-06	6.1e-06
2	TCGA	Breast Invasive Carcinoma	0.0158	0.0083	0.00230	0.010	0.008	0.001	NA	0.004	2.8e-03	7.2e-03	2.1e-01	NA	5.2e-02
3	TCGA	Brain Lower Grade Glioma	0.0657	0.0285	0.00003	0.038	0.048	0.044	NA	0.032	3.8e-05	3.4e-06	9.5e-06	NA	1.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.8	1.7	-1.3	0.5	-0.7
Bipolar Disorder or Schizophrenia	1.1	2.6	4.0	-2.0	1.0	-1.7
Depressed Affect (Nagel 2018)	1.0	2.0	5.4	0.8	0.1	2.3
Depression (Nagel 2018)	1.0	1.5	3.6	0.8	-0.4	1.9
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.9	0.5	-2.0	-1.1
Neuroticism (Nagel 2018)	1.4	3.4	7.2	1.6	-0.7	2.7
Schizophrenia (2018)	0.9	1.9	2.7	-1.5	0.9	-1.6
Schizophrenia vs Biploar Disorder	0.1	0.1	0.3	-0.5	-0.2	-0.1
Worry (Nagel 2018)	0.7	1.4	2.8	1.1	-0.4	1.7
Alzheimer’s Disease (in mother)	0.6	0.7	1.5	-0.1	1.2	0.6
Alzheimer’s Disease (in father)	2.7	2.9	5.0	1.9	-2.2	0.4
Alzheimer’s Disease (including proxy)	1.5	2.1	3.7	1.9	-1.0	1.3
Crohns Disease (2017)	1.3	2.9	5.2	-1.3	2.3	-1.3
Irritable Bowel Disease (IBD)	1.3	3.0	6.2	-1.2	2.5	-1.2
Ulcerative Colitis (UC)	1.6	3.0	6.0	-1.4	2.4	-1.1
Major Depression (MDD)	2.3	2.8	4.9	1.8	-0.7	2.2
Reaction Time	0.2	0.3	0.9	0.2	0.9	-0.0
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.7	-0.3	-1.3	-1.2
Breast Cancer	0.5	1.2	2.5	0.7	-0.8	1.6
Ovarian Cancer	0.7	0.9	1.5	0.4	-1.2	1.0
Prostate Cancer	1.8	2.6	4.7	2.2	-0.3	1.7
Age at First Birth	1.1	1.6	3.3	-0.5	-1.1	-1.8
Bipolar Disorder (2011)	1.0	1.0	1.4	-1.2	0.9	-0.9
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	-0.5	1.0	-0.2
Coronary Artery Disease (CAD)	0.8	0.9	2.0	-0.8	0.4	-1.4
Crohns Disease (2012)	1.3	2.0	4.2	-1.2	0.7	-2.0
Mean Putamen Volume	1.4	1.6	2.3	1.5	-0.8	1.4
Fasting Glucose	0.0	0.0	0.1	-0.1	-0.1	-0.3
HbA1C	0.3	0.4	0.6	-0.4	-0.7	-0.6
HDL Cholesterol	0.8	1.4	2.4	-1.6	-0.6	-1.2
LDL Cholesterol	6.8	10.7	11.9	-3.0	3.3	-3.5
Lupus	0.1	0.2	0.6	0.3	0.0	0.7
Neuroticism (2016)	1.8	2.6	3.8	1.8	-0.8	2.0
Primary Biliary Cirrhosis	0.5	0.7	1.1	-1.1	0.5	-0.8
Rheumatoid Arthritis	0.8	1.1	1.7	-1.3	0.6	-1.1
Schizophrenia (2014)	0.2	0.5	0.9	-1.0	-0.0	-0.8
Triglycerides	1.5	2.4	3.7	-1.6	1.9	-0.9
Type 2 Diabetes (T2D) (2012)	1.7	1.9	4.8	-1.0	2.2	0.1
Ulcerative Colitis	0.5	0.7	1.0	-1.0	1.0	-0.5
Blood Eosinophil Count	0.4	3.1	5.2	1.8	-0.8	2.3
Blood Platelet Count	0.4	4.5	7.6	1.8	-2.8	1.7
Blood Red Count	0.3	3.2	6.8	1.7	0.0	2.6
Blood White Count	0.0	0.3	0.4	-0.6	-0.4	0.5
Heel T-Score	1.6	12.4	21.8	4.7	-2.0	3.4
BMI	0.2	1.2	1.9	0.1	1.3	1.4
Height	1.2	23.9	58.1	3.7	-7.6	-0.2
Waist Hip Ratio (WHR)	0.9	4.0	7.2	0.8	2.7	2.1
Systolic Blood Pressure	0.9	4.3	7.0	-2.6	-0.2	-2.4
Smoking Status	0.9	2.1	5.8	-0.1	2.4	0.7
Allergy or Eczema	0.0	0.1	0.2	-0.4	-0.4	-0.1
Cardiovascular Disease	0.6	2.0	2.4	-1.5	1.2	-1.6
Hypothyroidism (self reported)	0.3	0.7	1.7	-1.3	-0.4	0.3
Respiratory disease	0.3	0.7	1.5	-1.2	0.8	0.1
Type 2 Diabetes (T2D) (2018)	2.3	4.3	4.7	-2.1	2.2	-2.0
Lung FEV1/FVC ratio	0.1	0.5	0.8	0.8	0.2	-0.9
Lung FVC	3.0	15.4	19.2	4.4	-4.1	3.2
Neuroticism	1.1	2.6	4.6	1.6	-0.7	2.1
Chronotype (morning person)	0.6	1.4	4.2	0.2	-2.0	0.1
Hair Pigment	0.0	1.3	4.0	2.0	0.1	-0.2
Tanning	0.0	0.3	0.4	0.1	-0.7	-0.6
Hand grip strength (left)	2.4	6.3	12.2	2.6	-3.5	0.0
Number of treatments/medications taken	0.7	1.3	2.3	-1.5	0.7	-1.0
Average weekly spirits intake	1.0	1.3	1.9	1.4	-0.1	1.4
Sensitivity / hurt feelings	0.0	0.1	0.1	0.3	-0.3	-0.1
Frequency of depressed mood in last 2 weeks	0.5	0.6	1.4	0.1	0.7	1.2
Hearing difficulty/problems: Yes	2.3	3.6	4.6	-2.2	1.3	-2.1
Relative age of first facial hair	2.0	4.1	4.5	2.0	-2.1	1.9
Other serious medical condition/disability diagnosed by doctor	2.3	3.0	5.7	-2.4	1.3	-1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	0.4	1.0	0.4
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	0.2	0.4
Systolic blood pressure, automated reading	0.3	1.0	1.6	-1.0	-0.6	-1.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	0.0	0.7	-0.2
Angina	1.4	1.9	2.5	-1.6	1.0	-1.5
Medication for hormone replacement therapy	0.1	0.1	0.1	0.4	-0.1	0.3
Vitamin and mineral supplements	0.2	0.3	0.7	-0.4	0.3	0.9
Supplements: Zinc	0.2	0.2	0.7	0.2	0.1	-0.8
Medication: Co-codamol	1.7	2.0	4.0	1.3	-2.0	0.5
Medication: Metformin	5.6	7.8	10.4	-3.2	2.3	-2.8
Diabetes (father)	0.1	0.1	0.1	-0.1	0.3	-0.4
Diabetes (mother)	0.7	0.9	1.5	-0.7	0.9	-1.2
Severe depression (siblings)	0.1	0.2	0.3	-0.4	0.6	0.0
Pack years adult smoking proportion	0.2	0.4	0.9	-0.4	0.2	0.9
Impedance of leg (right)	0.8	3.9	7.1	-2.2	0.0	-2.7
Leg fat-free mass (left)	0.4	2.3	3.2	1.8	-1.4	1.3
Trunk fat percentage	0.1	0.2	0.5	-0.7	0.5	0.1
Hand grip strength (right)	1.8	4.8	11.5	1.7	-3.4	0.4
Townsend deprivation index at recruitment	1.0	1.4	2.8	-0.5	1.7	1.1
Current tobacco smoking	1.4	2.2	5.4	-0.6	2.3	1.0
Average weekly fortified wine intake	1.1	1.3	2.0	-1.4	1.4	-0.1
Maternal smoking around birth	0.5	0.8	1.9	-0.6	1.4	0.0
Fed-up feelings	0.5	0.9	2.2	0.0	0.7	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.1	0.6	0.3	2.0
Relative age voice broke	1.3	2.0	3.8	1.9	-0.6	1.3
Taking other prescription medications	0.2	0.3	0.5	-0.6	-0.7	0.0
Age when periods started (menarche)	0.6	1.5	1.9	-1.4	1.2	-1.1
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.1	-0.2	1.1	0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.6	3.6	4.0	-2.0	2.0	-1.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.6	-0.2	0.6
Qualifications: CSEs or equivalent	0.4	0.5	1.6	-0.1	1.3	-0.0
Serious illness, injury or assault to yourself	1.0	1.2	1.8	-1.2	1.3	-0.6
High blood pressure	0.1	0.4	1.0	-0.2	-1.0	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.5	-0.7	-0.4	-0.3
Multivitamins +/- minerals	0.4	0.5	0.8	0.7	-0.9	0.6
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.1	0.0	1.0
Supplements: Glucosamine	0.5	0.6	1.5	0.5	-1.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.3	0.5	-1.5	0.7
Medication: Atenolol	4.1	5.1	5.6	-2.3	2.4	-2.1
Medication: Levothyroxine sodium	0.3	0.4	1.2	-1.1	0.4	-0.1
Sitting height	1.6	11.1	30.1	1.5	-5.5	-0.9
Chronic bronchitis/emphysema (father)	0.3	0.4	0.7	-0.3	0.8	-0.5
High blood pressure (mother)	0.4	0.6	1.7	-0.2	-1.3	-0.0
Body mass index (BMI)	0.5	2.0	4.5	-0.2	2.1	1.2
Impedance of leg (left)	0.9	4.6	7.9	-2.4	-0.5	-2.8
Leg predicted mass (left)	0.4	2.2	3.1	1.8	-1.3	1.3
Trunk fat mass	0.0	0.1	0.3	0.1	-0.2	0.6
Waist circumference	0.4	1.5	2.4	0.4	1.6	1.4
Number of incorrect matches in round	2.3	3.8	6.3	2.1	-2.5	0.9
Past tobacco smoking	1.5	2.8	5.9	-2.4	0.2	-1.6
Alcohol usually taken with meals	0.0	0.0	0.1	-0.3	-0.0	-0.2
Nervous feelings	0.7	1.3	2.9	0.9	0.4	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.6	0.4	0.6	1.3
Hearing difficulty/problems with background noise	1.0	1.6	2.2	-1.5	1.2	-1.2
Hair/balding pattern: Pattern 2	0.8	1.0	2.1	-0.9	0.1	-1.4
Had menopause	1.1	1.3	2.1	1.5	0.4	1.3
Had other major operations	0.4	0.5	1.1	-1.1	0.6	-0.1
Forced vital capacity (FVC)	4.6	17.8	34.2	4.1	-5.8	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	2.1	-1.0	1.4	-0.6
Ever unenthusiastic/disinterested for a whole week	4.6	5.6	8.5	2.2	-1.9	2.9
Qualifications: None of the above	0.3	0.7	1.3	1.1	0.1	0.9
Financial difficulties in last 2 years	1.3	1.7	2.5	-1.6	1.4	-0.9
Mouth/teeth dental problems	0.1	0.1	0.2	0.4	-0.5	-0.2
Heart attack	0.1	0.1	0.3	0.1	0.5	0.3
Allergy	0.3	0.7	1.7	1.3	-0.5	0.5
Pain all over the body in last month	2.0	2.2	3.6	-1.9	1.1	-1.2
Diabetes (self-reported)	2.2	3.4	3.7	-1.9	1.9	-1.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.3	-0.7	-0.1	-1.1
Medication: Ramipril	0.5	0.6	1.4	0.6	-1.2	0.1
Medication: Simvastatin	3.0	4.5	5.2	-2.0	2.3	-2.1
Fluid intelligence score	0.2	0.4	0.8	0.2	-0.9	-0.5
Illnesses of siblings	0.1	0.1	0.2	-0.3	0.4	0.3
Neuroticism score	0.7	1.5	3.7	0.6	0.7	1.9
Weight	0.2	1.0	1.4	1.1	-0.6	1.2
Impedance of arm (right)	0.3	1.4	2.0	-0.5	-1.4	-1.3
Arm fat percentage (right)	0.4	1.5	3.6	-0.7	1.9	0.8
Trunk fat-free mass	1.0	5.7	8.4	2.9	-2.4	1.7
Hip circumference	0.1	0.3	0.4	0.5	-0.6	0.5
Time employed in main current job	1.0	1.2	1.3	-0.9	1.1	-1.1
Alcohol intake versus 10 years previously	0.1	0.2	0.3	0.4	-0.6	-0.2
Father’s age at death	3.3	4.4	6.7	2.5	-2.6	0.6
Worrier / anxious feelings	0.3	0.6	1.4	1.2	-0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.7	-0.2	0.2	1.3
Falls in the last year	0.7	0.9	1.4	-0.5	1.1	1.2
Hair/balding pattern: Pattern 3	1.4	2.0	3.6	-1.4	-0.8	-1.9
Number of live births	2.4	3.4	6.6	2.6	0.2	1.9
Forced expiratory volume in 1-second (FEV1)	4.2	14.0	27.4	3.8	-5.2	0.7
Pulse rate	0.6	1.1	2.0	0.9	-0.6	1.4
Happiness	2.3	2.8	6.4	1.4	0.1	2.5
Noisy workplace	0.7	0.9	2.3	0.5	-1.5	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.4	-0.1	0.0	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.2	-0.4	-0.4	0.4
Mouth/teeth dental problems: Dentures	0.9	1.5	1.9	-1.1	1.2	-1.4
Asthma	1.9	3.8	6.0	-2.5	2.3	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.2	1.1	-0.3
Medication: Cholesterol lowering	4.1	6.4	11.3	-2.3	3.4	-1.6
Depression (self-reported)	2.0	2.5	5.5	1.3	-0.3	2.3
Medication: Lansoprazole	1.4	1.6	3.1	-1.3	-0.4	-1.8
Prospective memory result	0.1	0.2	0.2	-0.5	0.4	0.2
Lung cancer (father)	0.1	0.2	0.5	0.1	0.2	0.7
Illnesses of mother	0.2	0.2	0.3	-0.6	0.3	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.1	22.3	3.3	-4.7	0.4
Pulse wave Arterial Stiffness index	0.7	0.8	1.2	1.1	-0.5	1.0
Impedance of arm (left)	0.3	1.3	2.9	-0.5	-1.7	-1.0
Arm fat mass (right)	0.2	0.9	1.5	0.1	1.2	1.0
Trunk predicted mass	0.9	5.4	7.9	2.8	-2.4	1.6
Standing height	1.5	14.5	33.1	3.2	-5.8	0.3
Length of working week for main job	1.5	1.7	2.8	1.3	-1.7	0.8
Exposure to tobacco smoke at home	0.3	0.4	0.6	-0.8	0.6	0.4
Breastfed as a baby	0.2	0.3	0.5	0.7	-0.1	0.6
Tense / ‘highly strung’	2.1	3.4	6.1	2.0	-0.4	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	2.7	1.2	-1.3	1.6
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.3	0.2	0.0
Birth weight of first child	0.9	1.6	4.2	0.8	-2.0	0.2
Peak expiratory flow (PEF)	2.4	5.7	10.6	2.5	-3.3	0.0
Pulse wave reflection index	1.4	1.7	4.8	-0.1	2.2	-0.4
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.1	-0.1	-0.3	1.4
Loud music exposure frequency	0.2	0.3	0.3	-0.5	0.6	-0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.7	0.8	-0.7	0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	-0.2	-0.9	0.0
Blood clot in the leg (DVT)	0.0	0.0	0.1	-0.1	0.0	0.3
Medication: Paracetamol	0.3	0.5	1.3	0.2	0.5	1.1
Headache pain in last month	0.4	0.7	1.3	-0.0	1.1	0.9
Medication for cholesterol, blood pressure or diabetes	1.3	2.1	3.6	1.2	-1.9	1.1
Glaucoma (self-reported)	1.6	1.9	5.0	0.8	-2.2	-0.5
Gout (self-reported)	3.0	4.0	5.9	2.4	-1.8	1.7
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.9	-2.0	0.3	-0.6
Medication: Amlodipine	0.1	0.1	0.3	0.1	0.6	0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.2	-1.1	0.7	0.3
Birth weight	4.1	8.8	16.2	2.9	-4.0	1.4
Chronic bronchitis/emphysema (mother)	1.0	1.2	1.7	1.1	-0.8	1.3
High blood pressure (siblings)	0.1	0.2	0.4	-0.2	-0.7	0.2
Forced vital capacity (FVC), Best measure	4.6	16.8	32.0	4.0	-5.7	1.5
Body fat percentage	0.2	0.7	1.4	-0.9	1.2	0.1
Leg fat percentage (right)	0.5	2.0	4.8	-1.0	2.2	0.1
Arm fat-free mass (right)	0.4	1.9	2.5	1.6	-1.2	1.2
Exposure to tobacco smoke outside home	0.7	0.9	2.1	-1.4	0.8	0.3
Comparative body size at age 10	0.5	1.4	2.7	1.6	-0.3	1.2
Number of full brothers	0.7	0.9	1.6	-0.6	1.3	0.8
Worry too long after embarrassment	0.3	0.5	0.7	0.8	-0.7	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.3	-0.1	-1.5	0.0
Wheeze or whistling in the chest in last year	1.5	2.6	5.1	-2.2	1.5	0.8
Number of children fathered	3.1	3.5	5.2	2.0	-2.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	5.6	-1.0	2.4	-0.6
Age at first live birth	1.1	1.9	4.3	-0.0	-2.1	-1.2
Pulse wave peak to peak time	0.6	0.7	1.4	-0.9	0.0	-1.2
Health satisfaction	0.6	0.7	1.7	0.3	0.6	1.3
Shortness of breath walking on level ground	1.2	1.4	3.1	-1.0	1.8	0.4
Qualifications: College or University degree	0.1	0.4	0.7	-0.5	-0.4	-0.8
Eye problems/disorders: None of the above	0.5	0.6	1.4	-1.2	0.4	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.5	-0.4	0.7	0.4
Emphysema/chronic bronchitis	1.9	2.2	5.2	-1.0	2.3	-0.6
Medication for pain relief, constipation, heartburn	0.3	0.4	0.8	0.7	-0.9	0.0
Neck or shoulder pain in last month	0.6	0.8	1.6	-0.9	1.3	0.1
Medication: Blood pressure	0.4	0.8	1.4	-0.9	0.2	-1.2
Angina (self-reported)	1.3	1.7	2.2	-1.5	1.0	-1.3
Migraine (self-reported)	0.7	0.8	2.0	0.7	-0.1	1.4
Medication: Ibuprofen	0.1	0.2	0.4	0.3	0.6	0.2
Medication: Allopurinol	5.1	6.8	11.0	3.3	-2.3	2.1
Medication: Omeprazole	0.1	0.1	0.3	-0.2	0.5	0.3
Medication: Seretide 50 evohaler	2.5	2.9	4.0	-1.9	2.0	-0.9
Mean time to correctly identify matches	0.2	0.4	1.1	1.1	-0.0	-0.0
Heart disease (mother)	1.0	1.3	3.0	0.8	0.3	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.6	-0.6	1.3	-0.7
Whole body fat mass	0.1	0.2	0.5	0.1	0.5	0.7
Leg fat mass (right)	0.2	0.6	1.5	-0.4	1.2	0.5
Arm predicted mass (right)	0.6	2.8	3.9	2.0	-1.7	1.4
Pulse rate, automated reading	0.2	0.6	1.0	-1.0	0.7	0.4
Alcohol intake frequency.	1.2	2.9	7.3	1.0	-2.7	-0.5
Comparative height size at age 10	1.6	8.7	20.1	2.4	-4.5	0.0
Number of full sisters	0.7	0.9	1.4	1.1	0.2	1.2
Suffer from ‘nerves’	0.1	0.2	0.5	-0.7	0.4	0.1
Overall health rating	1.9	4.0	6.4	-2.3	2.5	-0.5
Chest pain or discomfort	0.6	0.9	1.8	-0.6	0.8	1.3
Had major operations	1.2	1.4	2.2	1.2	0.6	1.5
Age at last live birth	0.7	1.0	2.5	0.8	-1.6	0.0
Family relationship satisfaction	4.1	5.1	8.1	2.0	-1.8	2.8
Leg pain on walking	0.2	0.2	0.3	0.4	-0.5	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.2	0.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	0.1	0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.8	0.5	-0.9	0.5
Medication: Aspirin	2.0	2.7	4.0	-2.0	1.3	-1.5
Supplements: Vitamin C	0.8	1.0	2.4	-0.4	0.6	-1.6
Knee pain experienced in last month	0.3	0.5	1.1	1.1	0.2	0.5
Hypertension (Self-reported)	0.2	0.5	0.7	-0.5	-0.7	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.6	0.8	-0.4	0.6
Illnesses of father: Heart disease	2.4	3.3	6.0	-1.6	2.5	-1.2
Illnesses of siblings: Diabetes	0.2	0.2	0.3	-0.3	0.5	-0.5
Smoking status: Previous	0.8	1.2	2.9	1.7	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.2	0.3	-1.1	-0.4
Whole body fat-free mass	0.7	3.9	5.5	2.4	-1.9	1.6
Leg fat-free mass (right)	0.4	2.3	2.8	1.7	-1.5	1.3
Arm fat percentage (left)	0.3	1.3	2.8	-0.5	1.7	1.0
Average weekly red wine intake	0.0	0.1	0.2	0.2	-0.4	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.9	-0.5	0.3	1.0
Mood swings	1.5	2.7	7.0	1.0	-0.1	2.6
Loneliness, isolation	1.6	2.2	6.1	-0.7	2.5	0.2
Long-standing illness, disability or infirmity	1.5	2.3	3.7	-1.9	1.7	-0.7
Ever had bowel cancer screening	0.5	0.6	1.7	-1.3	-0.1	-0.4
Diabetes diagnosed by doctor	2.4	4.0	5.0	-2.2	1.8	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.1	-0.2	1.5	0.1
Friendships satisfaction	1.2	1.4	3.0	0.4	-1.1	1.7
Qualifications: nursing, teaching	0.2	0.3	0.4	0.2	-0.6	-0.6
Commuting to job workplace: Walk	0.3	0.3	0.5	-0.6	-0.2	-0.7
Eye problems/disorders: Cataract	1.1	1.2	2.2	1.5	-0.8	0.9
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	0.5	-0.4	0.8
Medication for cholesterol	1.0	1.5	2.0	1.4	-0.8	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.0	1.0	-0.3	0.1
Back pain experienced in last month	0.8	1.2	2.0	-1.4	1.1	-0.6
Mineral and other dietary supplements	0.5	0.7	1.5	-0.8	1.2	-0.1
Breast cancer (self-reported)	1.0	1.3	2.5	-1.6	0.3	-1.1
Asthma (self-reported)	1.8	3.5	6.2	-2.5	2.0	-0.6
Osteoporosis (self-reported)	2.1	2.5	3.9	-2.0	1.1	-1.6
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.1	0.8	0.5
Medication: Aspirin	3.2	4.1	5.4	-2.3	1.4	-2.3
Medication: Gliclazide	5.3	6.0	7.5	-2.7	2.0	-2.5
Illnesses of father: None of the above (group 1)	1.1	1.3	3.3	0.7	-1.8	0.5
Smoking status: Current	1.8	2.9	6.3	-0.3	2.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	2.1	0.1	-1.4	-1.4
Whole body water mass	0.6	3.6	5.2	2.3	-1.8	1.5
Leg predicted mass (right)	0.4	2.1	2.5	1.6	-1.5	1.3
Arm fat mass (left)	0.2	0.8	1.2	0.1	1.1	1.1
Number of self-reported non-cancer illnesses	0.3	0.6	1.5	-1.2	0.6	0.0
Average weekly champagne plus white wine intake	0.4	0.6	1.2	0.2	1.1	0.7
Miserableness	0.9	1.5	4.5	0.4	0.0	2.1
Guilty feelings	5.0	7.5	16.1	2.5	-0.3	4.0
Wears glasses or contact lenses	1.3	1.5	3.8	-0.2	-0.8	-2.0
Ever taken oral contraceptive pill	0.8	0.9	2.5	-0.3	0.4	-1.6
Hearing aid user	1.2	1.3	3.3	-0.7	1.8	0.4
Mother’s age at death	0.1	0.1	0.2	0.3	-0.5	-0.1
Financial situation satisfaction	1.9	2.3	3.2	-1.5	1.8	-1.2
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.2	-0.1	-0.7
Commuting to job workplace: Public transport	0.4	0.5	0.8	-0.7	0.1	-0.9
Eye problems/disorders: Glaucoma	2.8	3.4	8.2	1.3	-2.9	-0.3
Medication: Blood pressure	0.1	0.1	0.2	-0.4	-0.4	-0.2
Pain type(s) experienced in last month: Hip pain	2.7	3.4	6.1	-1.6	2.5	-1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.3	0.8	-1.1	-0.2
High cholesterol (Self-reported)	4.6	8.1	13.0	-2.6	3.6	-2.1
Medication: Bendroflumethiazide	1.0	1.5	2.9	-1.7	0.0	-1.3
Medication: Paracetamol	0.1	0.2	0.4	-0.1	0.7	0.4
Medication: Lisinopril	0.6	0.8	1.3	-1.2	0.5	-0.8
Medication: Atorvastatin	2.3	2.8	5.2	-1.4	2.3	-1.1
Illnesses of father: High blood pressure	0.7	0.8	1.1	-0.9	1.0	-0.8
Alcohol drinker status: Never	0.4	0.5	1.3	0.2	-1.1	-0.3
Ever smoked	1.0	1.7	3.9	2.0	-0.2	1.1
Basal metabolic rate	0.5	2.7	3.8	2.0	-1.4	1.4
Leg fat percentage (left)	0.5	1.7	3.8	-1.2	2.0	0.1
Arm fat-free mass (left)	0.4	2.2	3.1	1.8	-1.5	1.2
Number of operations (self-reported)	0.4	0.5	0.9	0.6	-0.5	1.0
Average weekly beer plus cider intake	1.2	1.8	3.3	-0.9	1.8	1.2
Irritability	0.4	0.6	1.7	-0.3	0.1	1.3
Risk taking	0.0	0.1	0.1	-0.2	0.4	-0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.1	-0.3	-0.5
Fractured/broken bones in last 5 years	4.1	5.3	6.0	2.4	-2.5	2.1
Age started oral contraceptive pill	0.2	0.3	0.6	-0.2	-0.7	-0.5
Diastolic blood pressure, automated reading	0.0	0.1	0.1	-0.1	-0.3	0.3
Ever depressed for a whole week	4.6	5.7	6.8	2.6	-1.9	2.6
Unable to work because of sickness or disability	0.4	0.5	0.9	-0.8	0.9	-0.1
Commuting to job workplace: Cycle	1.2	1.5	2.4	0.6	-1.3	1.6
Myopia	0.8	1.1	1.6	-1.3	0.6	-1.2
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.4	0.6	0.4	0.7
Cholesterol lowering medication	1.0	1.4	2.0	-1.1	1.4	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.8	-0.9	0.5	-0.5
Pain experienced in last month	1.2	2.0	4.4	1.2	-2.1	-0.4
Supplements: Calcium	0.5	0.6	1.1	-0.7	-0.2	-1.1
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.2	-0.8	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.3	0.0	0.5	0.2
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.2	-0.1	0.4
Heart disease (siblings)	0.2	0.3	0.5	-0.4	-0.3	-0.7
Alcohol drinker status: Previous	0.2	0.2	0.5	0.0	-0.3	-0.7
Pack years of smoking	0.1	0.2	0.3	-0.5	0.1	0.6
Impedance of whole body	0.5	2.7	4.2	-1.5	-1.4	-2.0
Leg fat mass (left)	0.1	0.5	1.2	-0.4	1.1	0.5
Arm predicted mass (left)	0.4	1.9	3.0	1.7	-1.2	1.2