Hub : Genes

MTX3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1650	0.0540	2.6e-04	0.004	NA	-0.004	NA	0.004	1.5e-01	NA	8.8e-01	NA	1.4e-01
2	GTEx	Spleen	0.2770	0.1100	6.2e-03	-0.010	NA	-0.005	NA	-0.010	7.0e-01	NA	4.7e-01	NA	7.0e-01
3	YFS	Blood	0.0499	0.0147	2.3e-05	0.021	0.016	0.034	0.03	0.037	1.1e-07	3.4e-06	2.6e-11	3.2e-10	2.4e-12
4	TCGA	Breast Invasive Carcinoma	0.0439	0.0183	1.3e-05	0.019	0.028	0.029	NA	0.027	7.7e-05	1.4e-06	1.1e-06	NA	2.3e-06
5	TCGA	Lung Adenocarcinoma	0.0220	0.0138	4.4e-03	0.022	0.013	0.001	NA	0.005	1.1e-03	9.2e-03	2.5e-01	NA	8.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.3	2.0	6.1	-0.6	-1.4	-2.5	-1.3	0.0
Bipolar Disorder or Schizophrenia	0.8	2.0	5.4	-0.1	-1.7	-2.3	-0.9	1.0
Depressed Affect (Nagel 2018)	2.8	5.9	10.4	2.1	-2.4	1.8	3.2	2.4
Depression (Nagel 2018)	1.1	1.7	3.6	0.6	-0.5	1.6	1.9	1.2
Intelligence (Savage-Jansen 2018)	1.0	3.0	4.4	-2.0	1.9	-1.2	-1.2	-2.1
Neuroticism (Nagel 2018)	3.6	8.6	13.4	2.8	-3.4	0.3	3.1	3.7
Schizophrenia (2018)	0.3	0.7	1.5	0.4	-0.9	-1.0	-0.1	1.2
Schizophrenia vs Biploar Disorder	2.7	3.6	7.0	-1.0	2.6	1.5	-1.1	-2.6
Worry (Nagel 2018)	6.3	13.3	22.7	3.7	-4.2	0.5	3.6	4.8
Alzheimer’s Disease (in mother)	0.4	0.4	1.6	-0.1	-1.3	-0.7	-0.1	-0.1
Alzheimer’s Disease (in father)	0.8	0.8	1.7	-1.0	0.4	0.1	-1.3	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.9	-0.6	-0.4	-0.3	-0.8	-0.9
Crohns Disease (2017)	0.2	0.4	1.5	0.6	0.4	-0.4	0.3	1.2
Irritable Bowel Disease (IBD)	0.6	1.5	5.1	1.3	0.0	-0.6	0.8	2.2
Ulcerative Colitis (UC)	0.6	1.1	3.5	1.1	0.4	-0.5	0.5	1.9
Major Depression (MDD)	0.3	0.3	1.1	0.2	-1.0	0.4	-0.2	0.4
Reaction Time	1.9	3.6	8.7	1.8	-3.0	-0.9	0.8	2.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	-0.5	0.6	-1.1	-0.4	-0.3
Breast Cancer	0.6	1.5	3.2	-1.4	1.4	0.8	-0.0	-1.8
Ovarian Cancer	0.1	0.2	0.6	-0.2	-0.3	-0.4	-0.1	0.7
Prostate Cancer	0.9	1.3	2.1	1.4	-0.6	0.3	1.4	1.4
Age at First Birth	1.4	2.0	4.7	-1.3	0.9	-0.7	-2.2	-1.6
Bipolar Disorder (2011)	1.6	1.5	2.8	0.3	-1.4	-1.5	0.5	1.7
Body Mass Index (BMI) (2010)	1.4	1.9	3.3	1.7	-1.8	0.8	1.2	1.0
Coronary Artery Disease (CAD)	0.6	0.7	1.1	0.4	1.0	1.0	-0.6	-1.0
Crohns Disease (2012)	0.2	0.3	1.1	0.1	1.1	-0.6	-0.1	0.3
Mean Putamen Volume	1.0	1.2	2.2	0.8	-1.0	0.4	1.5	1.3
Fasting Glucose	2.0	2.4	4.8	1.8	-0.6	1.6	2.2	1.1
HbA1C	2.5	2.7	8.0	0.5	1.9	2.8	1.3	-0.2
HDL Cholesterol	0.1	0.2	0.9	-0.3	0.9	0.1	-0.3	-0.2
LDL Cholesterol	0.4	0.7	1.4	-1.1	1.2	0.6	-0.0	-0.8
Lupus	0.2	0.2	0.7	0.6	0.2	0.3	0.1	0.8
Neuroticism (2016)	4.4	6.4	10.9	2.7	-1.9	1.2	3.0	3.3
Primary Biliary Cirrhosis	1.0	1.4	2.2	1.2	-1.0	0.1	1.4	1.5
Rheumatoid Arthritis	0.5	0.6	1.3	0.8	0.7	1.1	0.8	0.3
Schizophrenia (2014)	0.0	0.1	0.2	0.0	-0.5	0.1	0.3	0.3
Triglycerides	1.8	2.9	4.2	-2.0	1.1	-1.7	-2.1	-1.5
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.9	0.4	-0.5	-0.9	-0.2	1.0
Ulcerative Colitis	0.7	1.1	3.1	0.9	0.0	-0.2	1.2	1.8
Blood Eosinophil Count	0.2	1.8	5.4	-0.8	2.3	0.1	-0.6	-1.5
Blood Platelet Count	0.1	0.8	1.8	-0.6	1.4	0.3	-1.1	-0.7
Blood Red Count	0.1	0.7	1.6	1.0	0.8	0.0	1.2	0.7
Blood White Count	0.5	3.8	6.4	-2.4	2.4	-0.1	-1.0	-2.5
Heel T-Score	0.1	0.5	0.9	-0.4	-0.7	-1.0	-0.9	0.4
BMI	0.4	2.4	6.8	-1.7	0.6	0.4	-1.3	-2.6
Height	0.3	5.3	20.3	-1.0	4.5	0.7	-0.1	-2.2
Waist Hip Ratio (WHR)	0.3	1.4	2.7	-0.6	1.2	-0.7	-1.6	-1.4
Systolic Blood Pressure	1.0	4.9	10.1	2.4	-2.1	0.7	1.9	3.2
Smoking Status	1.9	4.5	10.3	-1.3	2.6	2.0	-0.2	-3.2
Allergy or Eczema	0.2	0.6	0.9	-1.0	-1.0	-0.9	0.5	-0.2
Cardiovascular Disease	0.1	0.5	1.4	1.2	-0.3	0.9	0.3	0.2
Hypothyroidism (self reported)	0.3	0.6	1.6	0.8	-0.8	-0.4	0.2	1.3
Respiratory disease	0.7	1.5	2.5	-1.3	0.6	-1.2	-1.3	-1.6
Type 2 Diabetes (T2D) (2018)	2.4	4.4	7.9	-2.2	2.8	-0.1	-1.8	-2.4
Lung FEV1/FVC ratio	0.1	0.3	1.3	-0.0	1.1	0.1	-0.1	0.0
Lung FVC	0.2	1.0	2.6	-0.3	0.6	0.9	1.1	-1.6
Neuroticism	4.2	10.2	16.7	3.5	-2.9	1.0	3.5	4.1
Chronotype (morning person)	0.2	0.6	1.4	-0.3	1.2	0.7	-0.1	-0.9
Hair Pigment	0.0	0.4	1.6	0.6	0.3	1.3	-0.0	-0.4
Tanning	0.1	1.1	2.4	0.4	1.0	1.6	1.4	-0.4
Hand grip strength (left)	1.1	2.8	5.8	-1.1	2.4	-0.9	-1.8	-1.7
Number of treatments/medications taken	0.2	0.4	1.5	-0.3	0.3	-0.3	-0.1	-1.2
Average weekly spirits intake	1.7	2.1	5.2	2.3	-1.1	0.4	1.4	1.4
Sensitivity / hurt feelings	3.0	5.1	11.0	1.8	-3.3	-1.2	1.1	3.0
Frequency of depressed mood in last 2 weeks	0.5	0.8	3.3	0.1	0.2	1.8	0.6	0.3
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.4	0.1	0.9	0.5	-0.1
Relative age of first facial hair	1.4	2.9	6.1	2.2	1.1	2.5	1.3	0.8
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.4	-1.3	-0.3	-0.9	-1.8	-0.8
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.4	0.2	-0.6	0.6	0.2	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	1.6	-0.1	0.5	1.3	0.9	0.4
Systolic blood pressure, automated reading	0.4	1.0	2.3	0.8	-1.5	0.5	0.5	1.3
Eye problems/disorders: Diabetes related eye disease	2.5	2.7	5.3	-2.3	1.4	-1.6	-1.7	-1.0
Angina	1.9	2.5	8.1	1.2	0.7	2.9	1.6	0.1
Medication for hormone replacement therapy	0.4	0.4	1.8	-0.2	0.4	-0.1	-1.4	-0.3
Vitamin and mineral supplements	0.1	0.2	0.7	-0.2	-0.9	-0.4	-0.2	-0.3
Supplements: Zinc	2.0	2.2	4.3	-1.5	0.4	-2.0	-2.1	-0.6
Medication: Co-codamol	0.4	0.4	1.0	-0.6	0.8	0.4	-0.1	-1.0
Medication: Metformin	4.9	6.9	9.7	-3.0	3.1	-1.7	-2.8	-2.3
Diabetes (father)	0.1	0.1	0.3	-0.4	-0.2	-0.5	0.0	-0.3
Diabetes (mother)	0.1	0.1	0.2	-0.1	0.2	0.4	0.2	-0.3
Severe depression (siblings)	0.6	0.7	1.0	1.0	-0.9	-0.7	0.1	1.0
Pack years adult smoking proportion	1.4	2.2	5.7	0.7	1.5	2.4	1.4	0.8
Impedance of leg (right)	1.6	7.7	12.2	3.5	-0.1	2.1	3.3	3.4
Leg fat-free mass (left)	1.9	10.0	17.8	-3.5	2.3	-1.6	-3.5	-4.2
Trunk fat percentage	0.4	1.5	3.9	-1.1	1.4	0.5	-0.2	-2.0
Hand grip strength (right)	1.5	4.2	7.7	-1.6	2.8	-0.2	-2.0	-2.6
Townsend deprivation index at recruitment	0.6	0.8	1.4	-0.8	0.9	0.2	-1.2	-1.0
Current tobacco smoking	0.8	1.3	4.2	0.8	-0.3	2.0	1.3	0.2
Average weekly fortified wine intake	2.2	2.6	6.6	0.4	-2.6	-1.8	-1.2	1.2
Maternal smoking around birth	0.8	1.1	3.0	-1.2	1.7	0.3	-0.9	-0.7
Fed-up feelings	1.5	2.6	3.4	1.4	-1.5	1.5	1.8	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.7	0.0	-0.0	0.5	1.3	1.0
Relative age voice broke	0.6	0.9	1.6	1.0	0.1	1.3	0.9	1.1
Taking other prescription medications	0.6	0.9	1.4	1.2	-0.9	0.3	1.0	1.1
Age when periods started (menarche)	0.2	0.4	1.2	1.1	-0.1	0.9	0.4	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	-0.8	0.5	-0.0	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.6	-0.5	0.7	1.1	-0.2	-1.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.3	0.0	-0.8	-0.9	-0.1
Qualifications: CSEs or equivalent	1.6	2.2	3.3	-1.2	1.7	1.0	-1.5	-1.8
Serious illness, injury or assault to yourself	2.2	2.6	6.1	-1.8	0.4	-0.6	-2.5	-1.8
High blood pressure	0.2	0.6	2.0	0.5	0.4	1.4	0.3	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.8	-0.2	-0.6	-0.4	0.9	0.6
Multivitamins +/- minerals	0.6	0.8	1.6	-0.9	1.3	0.1	-1.1	-0.6
Stomach or abdominal pain in last month	0.4	0.5	1.2	0.7	0.6	-0.4	0.4	1.1
Supplements: Glucosamine	1.7	2.2	3.7	-1.6	1.1	-0.9	-1.6	-1.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.5	1.1	-0.7	0.8	0.6	-0.4	-1.0
Medication: Atenolol	0.4	0.5	1.1	0.6	0.9	0.4	1.1	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.5	0.0	0.1	0.4	0.7	0.6
Sitting height	0.4	2.7	8.4	-1.2	2.9	-1.0	-0.8	-1.4
Chronic bronchitis/emphysema (father)	2.1	2.4	8.6	1.0	0.6	2.9	1.4	0.6
High blood pressure (mother)	0.5	0.7	3.0	-0.1	-1.7	0.4	0.3	0.3
Body mass index (BMI)	1.1	4.9	9.4	-2.6	1.1	-0.9	-2.5	-3.1
Impedance of leg (left)	1.3	6.5	10.5	3.2	0.2	1.7	3.1	3.0
Leg predicted mass (left)	1.8	9.5	16.9	-3.4	2.2	-1.6	-3.4	-4.1
Trunk fat mass	0.8	3.6	8.2	-2.0	2.2	0.1	-1.2	-2.9
Waist circumference	1.7	6.4	11.6	-2.9	1.9	-1.3	-2.5	-3.4
Number of incorrect matches in round	0.2	0.3	1.2	1.1	-0.0	0.2	0.3	0.1
Past tobacco smoking	3.4	6.2	12.3	2.4	-3.0	-0.1	2.1	3.5
Alcohol usually taken with meals	1.1	1.9	4.2	-0.6	-2.0	-2.0	-0.2	0.8
Nervous feelings	2.4	4.5	8.5	1.9	-2.3	0.4	2.2	2.9
Frequency of tenseness / restlessness in last 2 weeks	1.8	2.8	4.8	1.3	-1.1	2.1	2.2	1.3
Hearing difficulty/problems with background noise	0.2	0.3	0.7	-0.6	0.9	-0.2	-0.2	-0.5
Hair/balding pattern: Pattern 2	1.8	2.3	5.5	-1.9	0.4	-0.3	-1.4	-2.4
Had menopause	0.2	0.3	0.7	-0.7	-0.8	0.0	-0.0	0.5
Had other major operations	0.1	0.2	0.4	0.3	-0.2	0.7	0.4	0.3
Forced vital capacity (FVC)	0.7	2.5	5.9	-0.4	2.4	0.9	0.5	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	-0.2	0.4	0.5	-0.2	-0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	1.1	0.7	-1.0	-0.8	0.1	1.1
Qualifications: None of the above	0.5	1.1	2.0	-1.2	1.4	0.0	-0.8	-1.2
Financial difficulties in last 2 years	2.5	3.4	6.5	-2.0	1.2	1.4	-1.8	-2.5
Mouth/teeth dental problems	0.9	1.4	3.0	-1.3	1.7	-0.9	-0.5	-1.1
Heart attack	0.2	0.3	1.0	-0.2	-0.1	1.0	0.7	-0.1
Allergy	0.1	0.1	0.4	0.4	-0.0	0.2	-0.6	0.3
Pain all over the body in last month	0.7	0.8	1.3	-1.1	0.7	0.4	-0.9	-1.1
Diabetes (self-reported)	1.4	2.2	3.8	-1.8	1.9	-0.0	-1.2	-1.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	-0.2	-0.7	0.0	0.6	0.4
Medication: Ramipril	0.1	0.1	0.2	-0.0	0.2	0.4	-0.4	-0.5
Medication: Simvastatin	0.2	0.3	0.8	0.5	-0.6	0.4	0.9	0.2
Fluid intelligence score	0.0	0.1	0.3	-0.1	0.5	-0.1	0.4	-0.2
Illnesses of siblings	1.0	1.3	2.4	1.4	-0.5	0.7	1.6	1.3
Neuroticism score	3.0	6.2	11.5	2.3	-2.7	0.5	2.5	3.4
Weight	1.7	8.5	15.4	-3.3	2.4	-1.3	-2.9	-3.9
Impedance of arm (right)	1.9	8.7	16.2	3.0	-1.2	1.5	4.0	3.8
Arm fat percentage (right)	0.3	1.1	2.9	-1.3	0.7	0.2	-0.7	-1.7
Trunk fat-free mass	1.9	11.1	17.3	-3.6	2.7	-1.9	-3.8	-4.2
Hip circumference	1.1	4.7	9.1	-2.6	1.8	-1.1	-1.8	-3.0
Time employed in main current job	1.3	1.5	2.2	1.4	-1.5	1.2	0.9	1.2
Alcohol intake versus 10 years previously	8.2	12.2	25.8	-2.5	5.1	3.3	-0.3	-4.3
Father’s age at death	0.3	0.4	1.1	0.1	-0.5	-0.2	1.0	0.7
Worrier / anxious feelings	2.3	4.3	8.1	1.8	-2.8	0.1	1.6	2.7
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.0	0.4	0.5	1.7	1.1	0.3
Falls in the last year	0.8	1.1	1.8	1.2	-1.4	1.0	0.9	0.5
Hair/balding pattern: Pattern 3	1.6	2.3	4.9	1.9	-0.5	0.4	1.6	2.2
Number of live births	1.4	1.9	5.9	1.2	-0.7	-1.2	0.7	2.4
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	6.0	-0.1	2.4	0.5	0.5	-1.8
Pulse rate	0.8	1.3	3.4	1.8	-0.8	-0.5	0.1	1.6
Happiness	0.6	0.8	2.2	0.5	-1.5	-1.0	0.1	0.6
Noisy workplace	0.2	0.3	0.9	0.2	0.7	0.9	0.3	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	-0.4	-0.8	-0.9	-0.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	5.4	6.2	11.8	-2.8	1.6	0.0	-3.0	-3.4
Mouth/teeth dental problems: Dentures	0.3	0.5	2.0	0.3	-1.4	0.0	0.1	0.4
Asthma	0.2	0.4	0.6	-0.5	-0.2	-0.7	-0.7	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	0.4	-1.0	-0.8	-0.3	0.4
Medication: Cholesterol lowering	0.2	0.3	0.7	0.8	0.3	0.7	0.5	-0.4
Depression (self-reported)	0.2	0.2	0.4	0.6	0.1	-0.4	0.2	0.6
Medication: Lansoprazole	0.8	0.9	2.0	-0.9	1.4	-0.7	-0.9	-0.8
Prospective memory result	0.5	0.6	1.4	-1.2	-0.1	-0.9	-0.7	-0.5
Lung cancer (father)	0.4	0.5	1.0	-0.6	0.3	1.0	-0.1	-1.0
Illnesses of mother	0.5	0.6	2.0	0.6	0.0	-1.4	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.1	-0.3	2.0	0.0	0.2	-1.7
Pulse wave Arterial Stiffness index	0.8	1.0	3.9	0.0	2.0	0.7	0.4	-0.6
Impedance of arm (left)	2.1	9.7	18.7	3.3	-1.1	1.6	4.3	3.9
Arm fat mass (right)	1.0	4.0	8.9	-2.3	1.4	-0.4	-1.9	-3.0
Trunk predicted mass	1.9	10.7	16.9	-3.5	2.7	-1.9	-3.7	-4.1
Standing height	0.3	3.3	8.8	-1.3	3.0	-1.3	-1.0	-1.8
Length of working week for main job	2.1	2.4	4.0	1.7	-0.0	1.1	2.0	1.9
Exposure to tobacco smoke at home	0.3	0.4	0.9	-0.3	0.6	0.5	-0.9	-0.5
Breastfed as a baby	2.6	3.3	6.6	-1.7	2.2	0.5	-1.3	-2.6
Tense / ‘highly strung’	3.3	5.4	8.0	2.5	-1.5	1.8	2.6	2.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.6	0.7	-0.3	-1.3	-0.3	1.2
Hair/balding pattern: Pattern 4	0.7	1.6	2.4	-1.5	1.0	-0.5	-1.4	-1.5
Birth weight of first child	0.3	0.6	1.0	-0.7	0.8	0.7	0.2	-1.0
Peak expiratory flow (PEF)	0.7	1.7	6.2	-0.4	2.5	0.7	0.3	-1.3
Pulse wave reflection index	0.3	0.3	1.2	-1.1	0.5	-0.1	0.3	-0.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.9	1.0	-1.4	-0.6	-0.4	1.2
Loud music exposure frequency	1.4	1.5	5.2	-0.2	-0.0	2.3	1.4	0.4
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	0.7	-1.1	0.5	0.5	0.4
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	3.4	1.8	-1.2	1.2	1.4	1.8
Blood clot in the leg (DVT)	0.3	0.4	0.7	0.2	0.8	0.5	0.8	-0.5
Medication: Paracetamol	0.3	0.6	1.7	-0.0	1.3	-0.1	-0.1	-1.0
Headache pain in last month	0.5	0.8	1.8	1.3	-0.8	-0.1	0.5	1.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.9	-0.1	-1.2	-1.1	0.4	1.7
Glaucoma (self-reported)	1.2	1.4	4.9	0.7	-2.2	0.6	0.8	0.8
Gout (self-reported)	0.2	0.3	0.6	-0.5	0.3	-0.8	-0.6	-0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.5	1.1	-0.9	-0.2	0.9	1.6
Medication: Amlodipine	0.0	0.0	0.2	-0.1	-0.4	0.0	-0.2	0.1
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.3	-0.6	-0.4	0.2	0.9
Birth weight	0.3	0.7	1.8	-0.1	-1.3	-1.1	-0.2	0.7
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.4	0.0	0.1	0.2	-0.0	0.6
High blood pressure (siblings)	2.4	3.5	6.6	-2.5	1.1	-0.8	-1.6	-2.6
Forced vital capacity (FVC), Best measure	0.4	1.5	3.8	-0.1	1.9	0.4	0.5	-1.8
Body fat percentage	0.4	1.4	3.6	-1.2	1.3	0.5	-0.4	-1.9
Leg fat percentage (right)	0.3	1.3	2.5	-1.1	1.2	0.6	-0.8	-1.6
Arm fat-free mass (right)	2.4	12.3	21.2	-3.6	3.2	-1.6	-3.8	-4.6
Exposure to tobacco smoke outside home	0.8	1.0	4.0	0.3	0.9	2.0	0.5	0.1
Comparative body size at age 10	1.2	3.2	6.0	-2.4	-0.6	-1.8	-1.5	-2.0
Number of full brothers	1.0	1.3	3.6	-0.4	-0.2	-1.7	-1.9	-0.0
Worry too long after embarrassment	2.7	4.5	7.4	1.9	-2.3	0.5	2.5	2.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	3.6	1.8	-0.8	0.7	1.6	1.9
Wheeze or whistling in the chest in last year	0.6	1.1	1.6	-1.2	1.1	1.3	-0.4	-0.9
Number of children fathered	0.1	0.1	0.4	-0.0	-0.2	-0.3	0.1	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.1	-0.2	0.8	0.7	0.4	-1.1
Age at first live birth	1.9	3.4	5.3	-1.9	1.3	-1.6	-2.3	-1.9
Pulse wave peak to peak time	0.6	0.7	2.4	-0.3	-1.5	-0.8	-0.6	0.1
Health satisfaction	0.6	0.7	2.1	-0.8	-0.1	-1.4	-0.9	-0.4
Shortness of breath walking on level ground	0.2	0.2	0.4	0.6	-0.2	0.6	0.1	0.5
Qualifications: College or University degree	0.6	2.0	5.6	-0.2	-2.0	-2.4	-0.5	0.3
Eye problems/disorders: None of the above	0.3	0.3	0.7	0.5	0.6	0.3	0.8	0.4
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.8	1.9	-0.3	1.5	1.4	1.5
Emphysema/chronic bronchitis	0.3	0.4	0.5	-0.3	-0.7	-0.6	-0.5	0.7
Medication for pain relief, constipation, heartburn	0.6	1.1	2.5	-0.5	-1.6	-1.1	-1.1	0.6
Neck or shoulder pain in last month	1.6	2.3	5.5	1.8	-0.8	2.4	1.5	0.5
Medication: Blood pressure	1.0	1.7	3.4	0.1	1.9	1.5	-0.4	-1.7
Angina (self-reported)	1.7	2.3	6.5	1.2	1.0	2.5	1.6	0.1
Migraine (self-reported)	0.3	0.4	1.0	0.8	0.0	-0.2	0.2	1.0
Medication: Ibuprofen	0.5	0.6	1.9	-0.5	-0.9	-1.4	-0.3	0.1
Medication: Allopurinol	0.1	0.1	0.3	-0.1	0.6	-0.1	-0.1	-0.2
Medication: Omeprazole	0.8	0.9	1.6	-0.1	0.8	1.3	1.1	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	1.1	0.8	-1.0	-0.0	0.9	1.0
Mean time to correctly identify matches	0.6	1.2	4.5	0.6	-2.1	-0.7	0.3	0.8
Heart disease (mother)	1.3	1.6	7.0	0.1	-0.1	2.6	0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.3	1.0	-0.5	0.6	1.1	1.1
Whole body fat mass	1.0	4.2	9.5	-2.2	1.9	-0.2	-1.7	-3.1
Leg fat mass (right)	1.1	4.3	8.8	-2.3	1.9	-0.2	-2.0	-3.0
Arm predicted mass (right)	2.4	12.3	21.8	-3.7	3.0	-1.5	-3.8	-4.7
Pulse rate, automated reading	0.3	1.0	2.5	-0.8	-0.3	-1.1	-1.6	-0.5
Alcohol intake frequency.	0.8	1.8	3.7	-0.6	1.7	1.9	0.4	-1.3
Comparative height size at age 10	0.4	2.5	4.1	-2.0	2.0	-1.0	-0.7	-1.7
Number of full sisters	0.4	0.5	1.1	-0.5	1.0	0.9	-0.1	-0.7
Suffer from ‘nerves’	3.4	5.3	11.2	2.2	-2.7	-0.6	1.6	3.4
Overall health rating	0.5	1.1	2.0	-1.4	-0.4	-1.0	-1.4	-0.6
Chest pain or discomfort	0.7	0.9	2.3	0.7	-0.1	1.5	1.2	0.7
Had major operations	0.1	0.2	0.5	-0.3	0.2	0.7	-0.4	-0.3
Age at last live birth	2.5	3.6	8.6	-1.5	0.1	-2.9	-2.5	-0.9
Family relationship satisfaction	0.9	1.1	2.9	0.7	-0.9	-1.7	-0.8	0.8
Leg pain on walking	2.7	3.4	6.2	-2.5	0.7	-1.2	-2.0	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.2	-0.3	0.6	1.5	-0.1	-1.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	-0.1	0.4	0.9	0.3	-0.2
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	4.7	1.8	-0.7	-0.7	2.2	2.1
Medication: Aspirin	1.4	1.9	3.3	1.8	-0.3	1.1	1.8	1.1
Supplements: Vitamin C	0.6	0.7	1.1	-0.6	0.7	-1.0	-1.0	-0.6
Knee pain experienced in last month	0.3	0.4	1.5	0.5	0.3	1.2	0.2	-0.3
Hypertension (Self-reported)	0.2	0.6	2.2	0.6	-0.1	1.5	0.3	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.2	0.1	0.3	0.3	1.1	-0.3
Illnesses of father: Heart disease	0.3	0.4	0.8	0.6	0.9	0.2	0.4	0.8
Illnesses of siblings: Diabetes	3.3	4.0	7.8	-1.7	2.8	-1.0	-2.1	-2.0
Smoking status: Previous	4.7	7.0	13.1	-2.4	3.4	-0.0	-2.2	-3.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	0.7	0.9	1.2	0.7	-0.3
Whole body fat-free mass	2.0	11.4	19.0	-3.6	2.6	-1.9	-3.8	-4.4
Leg fat-free mass (right)	2.0	10.8	18.4	-3.7	2.3	-2.0	-3.6	-4.3
Arm fat percentage (left)	0.3	1.0	2.8	-1.2	0.7	0.4	-0.4	-1.7
Average weekly red wine intake	2.0	3.0	11.0	0.7	-3.3	-0.9	0.5	1.5
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.1	0.7	0.4	1.8	1.3	0.2
Mood swings	1.7	3.1	4.6	2.0	-1.3	1.2	2.1	2.0
Loneliness, isolation	0.4	0.6	2.2	-0.4	-0.6	1.5	-0.1	0.1
Long-standing illness, disability or infirmity	0.9	1.3	2.2	-1.5	0.8	-0.2	-1.2	-1.5
Ever had bowel cancer screening	1.2	1.5	2.6	-1.1	1.6	-0.0	-1.6	-1.0
Diabetes diagnosed by doctor	1.8	2.9	6.2	-1.7	2.5	-0.3	-1.6	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.4	-0.4	-0.4	-0.8	0.5
Friendships satisfaction	1.7	2.2	4.5	0.6	-1.5	-2.1	0.3	1.9
Qualifications: nursing, teaching	0.6	1.0	3.2	0.9	-0.7	-0.3	0.3	1.8
Commuting to job workplace: Walk	0.4	0.5	1.4	0.7	-0.3	0.2	1.2	0.6
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.2	-0.5	0.3	-0.1	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.9	0.0	-0.8	-0.9	-0.8	0.4
Medication for cholesterol	0.1	0.1	0.4	0.1	0.6	0.1	0.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.0	-0.0	0.8	1.4	1.0	-1.0
Back pain experienced in last month	1.2	1.7	4.5	-0.8	2.1	0.9	-0.3	-1.6
Mineral and other dietary supplements	0.5	0.6	1.4	0.4	-1.2	0.6	0.8	0.7
Breast cancer (self-reported)	0.9	1.1	3.0	-1.7	-0.2	-1.2	-0.7	-0.7
Asthma (self-reported)	0.1	0.3	0.5	-0.4	-0.1	-0.6	-0.6	-0.7
Osteoporosis (self-reported)	1.4	1.7	2.5	1.2	-1.6	1.4	1.3	0.8
Osteoarthritis (self-reported)	4.5	5.8	12.0	-3.4	1.3	-0.7	-1.8	-3.5
Medication: Aspirin	1.2	1.6	3.0	1.7	-0.1	1.0	1.7	1.1
Medication: Gliclazide	1.4	1.6	5.0	-1.1	2.2	-0.4	-0.6	-1.0
Illnesses of father: None of the above (group 1)	1.0	1.3	1.9	1.3	-1.4	0.9	1.1	0.9
Smoking status: Current	1.0	1.5	3.7	1.0	-0.6	1.9	1.5	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	2.2	0.9	1.3	1.5	1.4	-0.9
Whole body water mass	2.1	12.0	20.1	-3.7	2.7	-1.9	-3.9	-4.5
Leg predicted mass (right)	2.0	10.6	18.0	-3.6	2.3	-1.9	-3.5	-4.2
Arm fat mass (left)	0.7	2.9	6.7	-2.1	1.1	-0.5	-1.6	-2.6
Number of self-reported non-cancer illnesses	0.2	0.3	1.0	-0.3	0.0	-1.0	-0.4	-0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.5	-0.1	-0.6	-0.7	-0.4	0.1
Miserableness	1.4	2.4	4.8	1.6	-1.1	0.0	1.8	2.2
Guilty feelings	0.6	0.9	2.0	-0.3	-1.4	-1.4	-0.7	0.3
Wears glasses or contact lenses	0.9	1.1	2.1	-1.4	0.3	-0.8	-0.7	-1.5
Ever taken oral contraceptive pill	1.6	1.8	3.4	-0.8	1.9	-1.2	-1.5	-1.2
Hearing aid user	2.6	3.0	4.8	2.2	-2.2	0.5	1.1	1.9
Mother’s age at death	0.2	0.2	0.3	-0.5	-0.5	-0.5	-0.4	-0.1
Financial situation satisfaction	0.9	1.1	1.9	0.7	-1.1	0.8	1.1	1.4
Tinnitus: Yes, now most or all of the time	2.3	2.7	5.4	2.0	-1.2	0.6	1.5	2.3
Commuting to job workplace: Public transport	0.4	0.5	1.3	-0.2	0.8	0.6	-0.2	-1.1
Eye problems/disorders: Glaucoma	1.4	1.6	6.6	0.4	-2.6	-0.2	0.4	1.0
Medication: Blood pressure	0.4	0.7	1.4	0.3	-1.1	0.2	1.2	1.0
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.5	-0.2	-0.2	0.2	-0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.1	-0.2	1.4	-0.9	-0.9	-0.6
High cholesterol (Self-reported)	0.2	0.3	0.7	0.3	0.2	0.8	0.6	-0.7
Medication: Bendroflumethiazide	0.2	0.2	0.6	0.1	-0.2	0.8	-0.0	-0.7
Medication: Paracetamol	0.1	0.2	0.5	-0.1	0.3	-0.3	0.6	-0.7
Medication: Lisinopril	1.4	1.8	3.6	-1.8	-0.4	-0.0	-1.4	-1.9
Medication: Atorvastatin	0.7	0.9	1.8	1.3	-1.3	0.8	0.2	0.4
Illnesses of father: High blood pressure	3.8	4.7	10.8	-2.5	1.7	-0.7	-1.6	-3.3
Alcohol drinker status: Never	0.3	0.4	1.4	-0.0	-1.2	-0.7	0.1	0.2
Ever smoked	2.4	4.3	8.5	-2.3	2.2	0.6	-1.5	-2.9
Basal metabolic rate	2.0	11.1	18.9	-3.6	2.5	-1.8	-3.7	-4.3
Leg fat percentage (left)	0.5	1.6	3.5	-1.3	1.4	0.5	-0.9	-1.9
Arm fat-free mass (left)	2.0	10.0	18.0	-3.4	2.3	-1.6	-3.6	-4.2
Number of operations (self-reported)	0.8	1.2	2.3	0.7	-1.5	0.7	0.4	1.5
Average weekly beer plus cider intake	0.1	0.2	0.4	0.4	0.0	0.6	0.4	0.1
Irritability	0.3	0.5	1.8	-0.4	1.3	-0.5	-0.1	-0.4
Risk taking	0.7	1.0	4.2	0.4	0.0	2.1	0.7	0.5
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	0.9	-0.1	0.9	0.6	1.1
Fractured/broken bones in last 5 years	0.5	0.6	1.1	0.7	-0.8	0.9	1.0	0.1
Age started oral contraceptive pill	2.1	2.6	6.4	-1.4	0.3	-2.5	-2.0	-0.7
Diastolic blood pressure, automated reading	0.0	0.2	0.4	-0.2	-0.3	0.6	-0.1	-0.4
Ever depressed for a whole week	0.5	0.7	1.7	0.8	-0.7	-0.0	0.8	1.3
Unable to work because of sickness or disability	1.9	2.4	4.5	1.5	1.2	2.1	2.0	0.2
Commuting to job workplace: Cycle	1.7	2.1	4.3	1.7	-0.8	0.3	1.5	2.1
Myopia	2.1	3.1	6.0	-2.2	0.7	-1.4	-1.5	-2.4
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.6	0.0	-0.4	-1.3	0.1	0.9
Cholesterol lowering medication	0.0	0.1	0.2	-0.4	-0.3	-0.2	-0.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.9	0.3	0.6	1.4	1.2	-0.9
Pain experienced in last month	0.5	0.9	2.0	0.3	-1.4	-1.2	0.3	0.8
Supplements: Calcium	0.2	0.2	0.4	-0.4	0.3	-0.3	-0.6	-0.5
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	-0.3	-1.3	-0.7	-0.4	0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	0.1	-0.2	1.2	0.9	0.1
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.2	0.1	1.1	0.5	0.8	-0.6
Heart disease (siblings)	0.6	0.7	1.2	-1.0	1.1	-0.2	-0.8	-0.8
Alcohol drinker status: Previous	2.0	2.3	4.7	-1.0	2.2	0.9	-1.0	-2.0
Pack years of smoking	1.0	1.5	3.5	0.2	1.6	1.9	0.9	0.6
Impedance of whole body	2.2	11.4	20.3	3.9	-0.8	2.0	4.5	4.1
Leg fat mass (left)	1.2	4.5	9.5	-2.4	1.9	-0.4	-2.0	-3.1
Arm predicted mass (left)	2.2	11.1	19.6	-3.5	2.6	-1.7	-3.7	-4.4