TWAS hub - MXI1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0660	0.0270	2.5e-03	0.077	0.016	0.068	-0.002	-0.002	1.2e-09	4.6e-03	1.1e-08	9.6e-01	5.8e-01
2	GTEx	Artery Aorta	0.2060	0.0630	1.8e-03	0.032	NA	0.048	NA	0.056	7.1e-03	NA	1.1e-03	NA	5.0e-04
3	GTEx	Cells Transformed fibroblasts	0.0970	0.0350	1.2e-03	0.057	NA	0.030	NA	0.048	4.6e-05	NA	2.6e-03	NA	1.6e-04
4	GTEx	Muscle Skeletal	0.1644	0.0378	7.6e-09	0.094	NA	0.118	NA	0.115	1.6e-09	NA	1.2e-11	NA	2.2e-11
5	GTEx	Nerve Tibial	0.1311	0.0511	8.6e-03	0.020	NA	0.012	NA	0.021	1.3e-02	NA	4.8e-02	NA	1.2e-02
6	GTEx	Skin Sun Exposed Lower leg	0.1270	0.0390	3.0e-04	0.057	NA	0.022	NA	0.029	1.6e-05	NA	5.3e-03	NA	1.7e-03
7	NTR	Blood	0.0257	0.0106	1.6e-03	0.004	0.008	0.007	0.008	0.007	1.1e-02	1.1e-03	1.7e-03	1.1e-03	1.6e-03
8	ROSMAP	Brain Pre-frontal Cortex	0.3895	0.0415	0.0e+00	0.385	0.332	0.437	0.418	0.434	1.8e-52	7.2e-44	1.3e-61	2.5e-58	3.1e-61
9	TCGA	Bladder Urothelial Carcinoma	0.0500	0.0240	2.6e-04	0.048	0.039	0.037	NA	0.041	6.6e-05	2.7e-04	3.9e-04	NA	2.0e-04
10	TCGA	Breast Invasive Carcinoma	0.0139	0.0077	2.3e-03	0.005	0.009	0.006	NA	0.006	3.2e-02	4.3e-03	1.4e-02	NA	1.6e-02
11	TCGA	Glioblastoma Multiforme	0.4720	0.1170	8.8e-06	-0.003	0.174	0.052	NA	0.056	4.0e-01	5.9e-06	1.1e-02	NA	8.5e-03
12	TCGA	Head and Neck Squamous Cell Carcinoma	0.0402	0.0206	9.1e-04	0.032	0.031	0.016	NA	0.027	1.4e-04	1.8e-04	5.7e-03	NA	4.9e-04
13	TCGA	Kidney Renal Clear Cell Carcinoma	0.0478	0.0207	9.6e-05	0.064	0.040	0.054	NA	0.057	1.1e-07	2.6e-05	9.8e-07	NA	4.8e-07
14	TCGA	Brain Lower Grade Glioma	0.0768	0.0285	5.8e-07	0.084	0.062	0.076	NA	0.080	8.3e-10	1.5e-07	6.2e-09	NA	2.4e-09
15	TCGA	Lung Squamous Cell Carcinoma	0.0448	0.0295	6.9e-03	-0.002	0.013	0.012	NA	-0.001	5.6e-01	1.1e-02	1.3e-02	NA	5.4e-01
16	TCGA	Pancreatic Adenocarcinoma	0.2600	0.1370	9.9e-04	0.061	0.037	0.006	NA	0.031	1.4e-03	1.1e-02	1.7e-01	NA	1.8e-02
17	TCGA	Prostate Adenocarcinoma	0.0485	0.0209	1.5e-05	0.037	0.045	0.057	NA	0.046	8.0e-05	1.5e-05	1.3e-06	NA	1.3e-05
18	TCGA	Stomach Adenocarcinoma	0.0810	0.0450	4.7e-03	0.037	0.026	-0.003	NA	0.009	1.0e-03	5.2e-03	7.6e-01	NA	6.3e-02
19	TCGA	Testicular Germ Cell Tumors	0.1390	0.0600	7.4e-05	0.122	0.113	0.132	NA	0.125	4.6e-05	8.4e-05	2.1e-05	NA	3.5e-05
20	TCGA	Thyroid Carcinoma	0.1090	0.0420	4.9e-07	0.054	0.070	0.077	NA	0.061	5.3e-06	2.2e-07	6.1e-08	NA	1.5e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Medication for cholesterol, blood pressure or diabetes	5.4	8.9	16.5	-4.0	0.9	-2.6	-2.6	-2.1	-3.2	-3.1	-3.0	-3.0	-2.8	-1.4	-3.8	-3.3	-4.1	-4.0	-2.5	-3.4	-3.1	-2.5	-2.4
Cardiovascular Disease	5.0	16.6	31.9	5.6	-1.1	3.2	3.7	3.2	4.6	3.8	4.3	3.4	3.9	1.2	5.2	4.9	5.7	4.7	3.8	4.5	4.0	3.1	4.2
Ovarian Cancer	4.2	5.6	14.5	-1.8	0.4	-3.6	-3.8	0.5	-1.0	-1.5	0.5	-3.5	-3.6	-0.3	-2.6	-1.5	-1.6	-2.4	-1.7	-3.1	-1.6	-3.7	-2.5
Tinnitus: Yes, now most or all of the time	4.2	4.9	8.5	2.4	0.7	2.6	2.1	1.1	1.9	1.8	1.9	2.7	1.7	2.5	2.1	2.9	2.7	2.5	1.6	2.9	2.4	2.5	1.6
Vascular/heart problems diagnosed by doctor	4.1	11.1	20.4	-4.2	0.4	-2.8	-3.5	-2.5	-3.4	-4.1	-3.3	-3.2	-3.2	-0.1	-4.5	-3.9	-4.3	-4.1	-2.8	-3.9	-2.9	-2.9	-2.8
Medication: Simvastatin	4.0	5.8	9.9	3.1	-0.7	2.3	2.5	1.5	2.4	1.8	2.1	2.5	2.5	1.5	2.9	2.7	3.1	3.0	1.7	2.9	2.7	2.3	2.5
Had menopause	3.6	4.5	8.2	-1.8	-0.7	-2.2	-2.9	-1.2	-2.1	-2.3	-1.0	-2.4	-2.7	-0.8	-2.6	-2.3	-1.9	-1.7	-2.2	-2.8	-2.0	-2.5	-2.7
Medication: Blood pressure	3.6	6.3	12.6	3.5	-0.7	1.9	1.8	1.8	2.7	3.0	2.8	2.4	2.1	1.1	3.1	3.0	3.6	3.2	2.2	2.9	2.5	1.9	1.8
Supplements: Calcium	3.6	4.0	6.5	-2.3	0.4	-1.8	-1.9	-1.1	-2.5	-1.5	-1.4	-2.1	-2.4	0.8	-2.6	-2.2	-2.2	-1.9	-2.5	-2.3	-2.0	-1.7	-2.4
High blood pressure	3.4	9.4	18.1	3.9	-0.4	2.4	3.0	2.2	3.2	3.7	3.2	3.0	2.9	-0.0	4.3	3.6	4.0	3.7	2.4	3.5	2.9	2.6	2.8
Back pain experienced in last month	3.4	4.9	8.2	1.5	1.6	2.5	2.7	1.1	2.3	1.8	1.5	2.2	2.2	2.3	2.7	2.6	1.9	2.4	2.4	2.9	2.2	2.5	2.1
Hypertension (Self-reported)	3.3	9.2	18.3	3.9	-0.6	2.3	3.0	2.2	3.0	3.6	3.1	2.9	3.0	0.0	4.3	3.5	4.0	3.6	2.2	3.4	3.0	2.5	2.9
Unable to work because of sickness or disability	3.3	4.3	10.7	2.3	0.5	0.5	1.4	3.3	2.4	0.9	3.2	1.0	1.1	1.1	2.5	2.7	2.7	2.4	2.5	2.0	2.2	0.7	2.0
Medication for hormone replacement therapy	3.2	3.5	8.4	-0.8	-0.3	-2.4	-2.4	0.5	-1.9	-1.8	0.2	-2.4	-2.9	-0.8	-2.2	-1.0	-0.7	-1.7	-2.1	-2.0	-2.2	-2.6	-2.8
Taking other prescription medications	3.1	4.8	7.8	1.8	1.8	2.2	2.5	2.4	2.5	1.8	2.1	2.3	1.8	1.3	2.5	2.7	2.2	2.1	2.1	2.8	2.3	2.1	2.3
Relative age voice broke	3.0	4.6	10.9	-2.7	-0.2	-0.6	-0.9	-2.8	-2.9	-2.5	-3.3	-0.5	-1.0	-1.1	-2.6	-2.9	-3.0	-2.1	-2.0	-1.8	-2.5	-0.4	-2.4
Coronary Artery Disease (CAD)	2.9	3.4	10.3	1.0	0.3	3.1	3.2	-0.2	1.1	2.4	-0.1	2.7	2.6	-0.1	2.0	1.5	1.1	1.7	0.1	2.3	0.9	3.0	1.2
Medication: Cholesterol lowering	2.9	4.5	8.8	2.9	-0.7	1.8	2.1	1.7	2.5	1.7	2.4	1.6	1.8	1.1	2.6	2.5	3.0	2.8	2.1	2.2	2.1	1.4	1.9
Shortness of breath walking on level ground	2.9	3.5	5.9	2.2	-0.5	2.2	1.9	0.3	1.7	1.9	0.9	2.1	2.4	1.2	2.2	2.0	2.2	1.8	1.4	2.4	2.1	2.1	2.0
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	6.4	1.7	0.6	1.5	2.3	1.1	1.8	1.3	1.5	1.8	1.9	0.2	2.2	2.1	1.8	1.6	1.8	2.1	1.5	1.6	2.5
Long-standing illness, disability or infirmity	2.8	4.4	8.0	1.6	1.4	2.8	2.4	1.3	1.5	2.6	1.3	2.7	2.2	1.0	1.9	2.2	1.8	2.0	1.9	2.8	1.9	2.8	2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.6	3.1	7.4	1.6	1.2	0.7	1.3	2.7	2.1	1.6	2.6	1.2	1.0	1.6	2.1	2.3	1.9	1.6	1.3	1.8	2.4	0.9	1.5
Medication: Metformin	2.5	3.6	7.7	2.8	-0.8	1.6	1.4	1.0	1.8	2.1	1.9	1.9	2.0	-0.2	2.6	2.2	2.7	2.4	1.6	2.3	1.2	1.6	1.5
Severe depression (siblings)	2.3	2.6	6.3	-0.1	-2.0	-1.8	-1.6	-0.6	-1.5	-0.8	-0.7	-2.3	-1.7	-1.0	-1.4	-1.1	-0.5	-1.9	-2.5	-2.1	-2.0	-2.1	-1.6
Birth weight	2.3	4.9	9.6	1.3	2.8	1.6	1.3	2.7	3.1	0.9	2.9	1.6	0.7	3.0	2.1	3.1	2.0	1.9	2.7	2.3	2.7	1.5	1.7
Hearing aid user	2.2	2.4	3.6	1.6	0.1	1.7	1.3	1.3	1.4	1.5	1.0	1.9	1.8	0.9	1.8	1.4	1.7	1.8	1.7	1.9	1.7	1.8	1.8
Illnesses of father: None of the above (group 1)	2.1	2.6	6.8	-1.0	0.1	-2.6	-2.1	0.4	-1.2	-1.1	0.5	-2.2	-2.6	-0.2	-1.6	-0.8	-0.8	-1.4	-1.9	-1.9	-1.5	-2.4	-2.0
Major Depression (MDD)	2.0	2.4	8.9	-0.2	-1.0	-2.9	-1.8	1.0	-0.8	-1.4	0.7	-2.8	-2.1	-1.2	-1.1	-0.6	-0.3	-1.6	-0.8	-1.9	-0.9	-3.0	-0.6
Reaction Time	2.0	3.9	7.9	2.4	-0.9	1.6	2.3	0.8	1.5	2.3	1.4	2.0	2.3	0.7	2.3	1.6	2.3	2.8	2.0	2.2	2.2	1.8	2.2
Age at First Birth	2.0	2.9	9.9	-3.1	2.3	-1.2	-1.5	-0.9	-1.6	-1.2	-1.2	-0.8	-2.0	-0.1	-2.2	-1.5	-2.9	-2.3	-0.5	-1.5	-1.3	-1.0	-1.2
Ever used hormone-replacement therapy (HRT)	2.0	2.5	5.2	-2.3	2.1	-1.4	-1.9	0.2	-1.2	-2.3	-0.4	-1.4	-2.2	0.4	-1.9	-1.1	-1.9	-1.8	-1.2	-1.6	-1.0	-1.4	-1.8
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	5.8	0.8	0.6	1.7	2.4	0.8	1.5	1.3	0.7	2.0	1.8	1.5	2.0	1.2	0.9	1.8	1.3	1.6	2.3	2.0	1.9
Time employed in main current job	1.9	2.2	4.1	1.5	1.1	1.4	0.9	0.6	1.5	0.9	1.5	1.7	1.1	1.7	1.3	2.0	1.8	1.6	1.3	1.9	1.7	1.6	1.5
Number of self-reported non-cancer illnesses	1.9	3.2	6.6	1.6	0.4	2.6	2.4	0.7	1.0	2.1	0.8	2.5	2.0	1.4	1.6	1.5	1.7	2.5	0.9	2.3	1.6	2.5	1.2
Myopia	1.9	2.8	6.9	-0.1	-2.0	-2.2	-2.0	-0.9	-0.5	-2.6	-0.4	-2.6	-1.6	-1.1	-1.6	-1.1	-0.5	-1.9	-1.8	-2.2	-1.1	-2.5	-0.6
Ever highly irritable/argumentative for 2 days	1.8	2.1	6.1	2.5	-1.8	-0.6	0.6	1.9	1.5	1.4	2.0	-0.4	0.7	-0.5	1.7	1.2	2.3	2.0	1.9	0.7	1.1	-0.5	1.1
Blood clot in the leg (DVT)	1.8	2.4	5.1	0.8	0.7	1.5	2.2	1.1	1.5	1.1	0.9	1.8	1.6	1.5	2.0	1.2	1.0	1.8	1.4	1.6	2.3	1.8	1.9
Medication: Lisinopril	1.8	2.3	6.2	2.2	-0.3	0.1	0.5	2.0	1.8	1.4	2.5	0.6	0.6	-0.2	2.1	2.1	2.3	1.9	1.4	1.5	1.4	0.2	1.2
Schizophrenia vs Biploar Disorder	1.7	2.2	5.1	-1.5	0.9	-1.6	-2.1	-0.0	-1.6	-1.1	-0.1	-1.6	-2.2	0.1	-1.7	-1.0	-1.2	-1.4	-1.9	-1.5	-1.7	-1.4	-2.2
Alcohol usually taken with meals	1.7	2.8	6.9	-0.5	-2.1	-1.4	-1.6	-1.6	-2.1	-0.8	-1.9	-1.4	-0.8	-2.6	-1.6	-1.8	-1.0	-2.1	-2.2	-1.7	-1.8	-1.4	-0.8
Qualifications: None of the above	1.7	3.7	9.4	1.2	1.0	3.0	2.7	-0.2	1.1	1.1	0.1	3.0	2.5	1.4	1.8	1.6	1.3	1.7	0.9	2.5	1.9	3.1	2.1
Illnesses of father: Heart disease	1.7	2.4	6.4	1.0	0.2	2.1	2.5	0.5	1.2	1.0	0.2	2.0	1.9	0.4	1.5	1.3	1.0	1.3	2.5	1.9	1.2	1.9	1.9
Maternal smoking around birth	1.6	2.3	6.6	2.6	-2.2	-1.0	0.2	2.4	1.3	1.4	2.3	-1.2	-0.0	-1.3	1.5	1.3	2.4	1.4	1.6	0.2	0.0	-1.3	0.4
Impedance of leg (left)	1.6	7.6	20.5	-2.2	-2.5	-0.6	-2.2	-4.4	-3.3	-1.9	-4.5	-0.9	-0.5	-3.6	-2.8	-3.8	-3.0	-2.7	-2.3	-2.4	-3.4	-0.8	-2.3
Alcohol intake versus 10 years previously	1.6	2.3	6.0	2.3	-2.0	1.5	1.3	0.1	0.6	2.3	0.5	1.3	1.9	1.1	1.3	1.0	2.0	2.4	0.7	1.6	1.1	1.5	1.2
Number of live births	1.6	2.2	5.8	-1.0	-0.9	-1.6	-1.8	-0.5	-1.9	-1.4	-0.6	-1.5	-1.8	-0.9	-1.5	-1.5	-1.1	-0.9	-2.4	-1.8	-1.5	-1.7	-2.0
Pulse wave reflection index	1.6	1.9	4.3	-1.6	0.1	-0.9	-1.1	-1.2	-2.1	-1.3	-1.3	-1.2	-1.1	-1.2	-1.6	-1.7	-1.7	-1.5	-1.4	-1.5	-1.7	-1.1	-1.3
Number of children fathered	1.6	1.8	8.5	1.3	0.9	-0.5	0.2	2.9	1.6	1.4	2.7	-0.1	-0.2	-0.0	1.5	1.9	1.6	0.4	0.3	0.7	1.4	-0.5	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.9	4.1	-1.2	0.3	-1.9	-2.0	0.2	-1.4	-1.8	-0.2	-1.9	-1.8	0.1	-1.7	-1.2	-1.2	-1.2	-0.9	-1.7	-0.8	-1.9	-1.1
Illnesses of siblings: Diabetes	1.6	1.9	9.7	1.1	-2.9	1.7	1.1	-3.1	-0.9	0.8	-2.1	1.3	1.7	-0.2	-0.4	-0.7	0.5	0.5	-0.7	0.6	-0.6	1.5	-0.5
High cholesterol (Self-reported)	1.6	2.8	6.7	2.6	-1.4	1.7	1.7	0.8	1.5	1.3	1.2	1.8	2.1	-0.1	2.0	1.7	2.4	2.0	0.7	1.9	1.8	1.5	1.7
Waist circumference	1.5	5.6	8.2	2.4	1.2	2.1	2.1	1.6	2.6	2.4	2.5	2.1	2.2	1.9	2.8	2.9	2.7	2.6	2.0	2.8	2.8	2.1	2.8
Exposure to tobacco smoke outside home	1.5	2.0	3.8	1.1	1.1	1.6	1.3	0.5	1.8	1.1	0.9	1.6	1.6	0.6	1.9	1.8	1.2	0.9	1.5	1.8	1.6	1.6	1.7
Age at last live birth	1.5	2.1	5.8	-0.6	-1.3	-2.4	-1.9	-0.5	-1.4	-0.7	-0.1	-1.9	-1.8	0.2	-1.5	-1.3	-0.7	-1.1	-2.2	-1.7	-0.8	-2.1	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.6	1.9	-0.8	0.8	1.7	1.3	1.6	1.7	1.4	0.6	0.9	0.9	1.6	1.5	1.9	2.1	0.7	1.1	1.2	0.6	0.6
Supplements: Vitamin C	1.5	1.7	5.1	-0.7	1.0	-1.8	-1.9	1.5	-0.0	-2.3	1.1	-1.9	-2.2	1.2	-0.9	-0.1	-0.4	-0.6	-0.5	-1.3	-0.1	-1.9	-1.0
Wears glasses or contact lenses	1.5	1.7	3.9	0.8	1.8	0.8	0.7	1.6	0.9	0.2	1.8	1.4	0.3	1.9	1.2	2.0	1.2	0.8	-0.2	1.4	2.0	0.9	1.6
Impedance of whole body	1.5	7.7	22.6	-2.2	-2.4	-0.4	-1.9	-4.8	-3.4	-0.9	-4.5	-0.6	-0.5	-3.9	-2.9	-3.7	-3.0	-2.7	-2.4	-2.3	-3.6	-0.7	-2.5
Hearing difficulty/problems: Yes	1.4	2.1	5.1	1.5	-0.4	2.2	1.9	-0.6	0.6	1.4	-0.1	2.1	2.1	0.6	1.4	1.2	1.4	1.4	0.0	2.0	1.1	2.3	1.2
Leg fat-free mass (left)	1.4	7.4	13.5	1.9	2.4	1.6	2.8	3.0	3.7	2.6	3.0	1.7	1.9	2.7	3.1	3.3	2.4	2.5	3.3	2.8	3.4	1.8	3.1
Leg predicted mass (left)	1.4	7.6	13.9	1.9	2.4	1.6	2.8	3.1	3.7	2.5	3.1	1.7	1.9	2.7	3.2	3.4	2.4	2.5	3.4	2.9	3.4	1.9	3.1
Hearing difficulty/problems with background noise	1.4	2.3	4.6	1.6	-0.5	2.0	2.1	-0.2	0.7	2.1	0.3	1.9	2.1	0.6	1.6	1.2	1.5	1.8	1.2	2.0	0.9	2.0	1.4
Father’s age at death	1.4	1.9	5.6	-1.9	-0.2	-0.3	-0.7	-2.0	-1.3	-1.5	-2.4	-0.7	-0.4	-1.5	-1.1	-2.1	-2.2	-1.5	-1.1	-1.5	-1.0	-0.6	-0.8
Osteoarthritis (self-reported)	1.4	1.8	4.0	-0.2	1.6	1.7	1.6	-0.3	1.2	1.1	-0.3	2.0	1.9	0.3	1.5	0.7	-0.2	1.0	1.7	1.4	1.4	1.9	1.7
Body mass index (BMI)	1.3	5.5	9.2	2.0	1.9	1.7	1.8	2.2	2.9	2.1	2.9	1.7	1.6	2.7	2.7	3.0	2.6	2.4	2.1	2.5	2.9	1.8	2.5
Heart attack	1.3	1.7	4.5	1.3	0.9	0.8	1.1	1.9	1.6	0.1	2.1	0.7	0.4	1.3	1.3	1.8	1.7	1.5	1.2	1.3	1.2	0.6	0.9
Arm fat percentage (right)	1.3	5.0	8.2	2.1	0.8	2.6	2.1	0.5	2.3	2.9	1.6	2.5	2.4	1.6	2.6	2.5	2.3	2.5	1.7	2.7	2.3	2.6	2.3
Worrier / anxious feelings	1.3	2.4	5.5	-1.8	1.8	-1.9	-2.3	0.9	-0.9	-1.8	0.1	-1.7	-2.2	-0.4	-1.5	-0.8	-1.6	-1.9	-1.3	-1.8	-0.6	-2.2	-1.1
Length of working week for main job	1.3	1.4	6.1	1.8	-0.6	-1.0	-0.5	2.5	1.2	1.4	2.2	-0.6	-0.1	0.6	1.0	1.4	1.8	0.7	0.9	0.3	0.8	-0.7	0.5
Eye problems/disorders: None of the above	1.3	1.5	5.4	-2.0	0.8	-0.3	0.4	-2.3	-0.5	-0.8	-2.0	-0.8	-0.3	-0.9	-0.8	-1.3	-2.1	-2.0	-0.4	-1.2	-0.8	-0.5	-0.0
Mean time to correctly identify matches	1.3	2.4	4.6	2.1	-0.6	1.6	1.5	0.5	1.0	1.3	1.3	1.9	1.6	0.5	1.8	1.7	2.1	2.0	1.3	2.0	1.6	1.6	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	7.3	1.0	-2.7	-1.7	-1.8	-0.2	-0.5	-1.4	0.3	-1.7	-0.8	-1.3	-0.5	-0.5	0.6	-0.1	-0.5	-1.3	-1.1	-1.7	-0.9
Prostate Cancer	1.2	1.7	6.4	-1.4	0.2	0.3	-0.3	-2.5	-1.7	-0.1	-2.1	0.3	-0.3	0.0	-1.6	-1.2	-1.6	-1.4	-2.2	-0.5	-1.1	0.5	-1.5
Mean Putamen Volume	1.2	1.4	3.8	-1.0	-1.0	-0.7	-0.4	-1.8	-1.7	-1.2	-1.9	-0.7	-0.3	-1.4	-1.0	-1.5	-1.3	-0.8	-0.7	-1.1	-1.4	-0.5	-1.1
Weight	1.2	6.1	12.3	1.7	2.4	1.8	2.2	2.2	3.5	2.0	2.6	1.8	1.8	2.5	2.9	3.1	2.2	2.1	2.8	2.6	3.2	1.9	3.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	4.3	0.9	0.4	1.0	1.3	0.7	0.9	2.1	0.9	1.1	1.0	1.6	0.9	0.9	1.0	1.5	1.0	1.2	1.5	1.0	1.3
Depression (self-reported)	1.2	1.5	4.0	1.3	0.5	0.4	0.9	1.4	2.0	1.4	1.5	0.5	0.8	0.4	1.6	1.6	1.4	1.1	1.4	1.1	1.4	0.4	1.5
Arm fat mass (right)	1.2	4.9	7.2	1.9	1.4	2.1	2.1	1.2	2.7	2.5	1.9	2.1	2.2	2.0	2.7	2.5	2.1	2.3	1.9	2.5	2.6	2.2	2.5
Health satisfaction	1.2	1.5	4.1	1.3	-0.2	1.5	1.2	0.5	0.6	2.0	0.8	1.8	1.3	0.4	1.3	1.2	1.4	1.3	0.4	1.6	1.0	1.6	0.9
Leg fat-free mass (right)	1.2	6.6	11.9	1.5	2.6	1.5	2.7	2.8	3.5	2.4	2.8	1.6	1.7	2.6	2.9	3.1	2.0	2.2	3.2	2.6	3.2	1.8	3.0
Arm fat percentage (left)	1.2	4.8	8.7	2.0	0.7	2.6	2.2	0.2	2.1	2.9	1.4	2.5	2.5	1.5	2.5	2.3	2.2	2.5	1.8	2.7	2.3	2.6	2.2
Medication: Aspirin	1.2	1.5	4.3	1.2	-0.1	1.8	1.8	0.3	0.9	2.1	0.5	1.4	1.3	0.6	1.0	0.9	1.2	1.8	1.1	1.4	0.8	1.4	0.6
Leg predicted mass (right)	1.2	6.4	11.8	1.5	2.5	1.5	2.6	2.9	3.4	2.3	2.8	1.6	1.7	2.6	2.9	3.1	2.0	2.2	3.1	2.6	3.2	1.7	3.0
Arm fat mass (left)	1.2	5.0	7.1	1.8	1.4	2.3	2.2	1.1	2.7	2.5	1.8	2.2	2.2	2.0	2.6	2.5	2.1	2.3	2.1	2.6	2.7	2.4	2.5
Basal metabolic rate	1.2	6.7	13.8	1.7	2.4	1.3	2.4	3.1	3.7	1.9	2.9	1.5	1.7	2.7	3.1	3.1	2.1	2.3	3.2	2.5	3.4	1.6	3.2
Ever depressed for a whole week	1.2	1.5	4.4	-0.7	-0.6	-1.8	-1.0	0.5	-1.3	-0.0	0.1	-2.1	-1.8	-0.2	-1.5	-1.1	-0.7	-1.1	-1.1	-1.5	-1.3	-2.1	-1.3
Schizophrenia (2018)	1.1	2.3	5.9	-0.8	0.0	-2.3	-2.1	1.8	-0.8	-1.4	0.6	-2.4	-2.1	-0.5	-1.3	-0.9	-0.7	-1.1	-0.9	-1.9	-1.2	-2.4	-1.2
Body Mass Index (BMI) (2010)	1.1	1.6	6.2	1.5	-0.3	-0.9	-0.2	2.5	1.6	-0.5	2.3	-1.0	-0.4	0.8	1.1	1.4	1.7	1.0	1.8	0.2	0.6	-1.0	0.6
Primary Biliary Cirrhosis	1.1	1.5	4.9	-0.7	-1.2	1.2	0.3	-2.1	-1.7	1.2	-2.2	0.9	0.9	-0.9	-0.8	-1.7	-1.0	0.0	-1.9	-0.1	-1.0	1.2	-0.7
Triglycerides	1.1	1.7	5.9	2.4	-2.4	-0.7	-0.0	2.0	1.1	1.2	1.8	-0.6	0.4	-1.0	1.4	0.8	2.2	1.4	0.7	0.2	0.4	-0.8	0.6
Ulcerative Colitis	1.1	1.6	3.9	-2.0	1.2	-0.2	-0.7	-0.9	-1.5	-1.1	-1.4	-0.5	-1.0	-0.5	-1.6	-1.1	-1.9	-1.8	-2.0	-0.9	-1.3	-0.3	-1.5
BMI	1.1	6.6	13.1	2.6	1.5	1.8	1.7	2.6	3.0	1.9	3.2	1.5	1.5	3.6	2.7	3.5	3.1	2.6	2.5	2.7	3.0	1.7	2.8
Systolic Blood Pressure	1.1	5.3	18.5	3.3	-4.3	2.8	2.4	-2.1	0.2	3.1	-1.0	2.3	3.6	-0.9	1.8	0.4	2.5	2.5	-0.1	2.2	0.7	2.7	1.2
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	5.2	1.8	-1.4	-0.6	-0.6	2.2	0.1	0.8	2.3	-0.3	-0.5	0.2	0.5	0.8	1.8	1.4	-0.4	0.2	0.3	-0.7	-0.0
Impedance of leg (right)	1.1	5.6	14.1	-1.5	-2.7	-0.6	-2.0	-3.7	-2.7	-1.6	-3.8	-0.9	-0.4	-3.3	-2.4	-3.2	-2.3	-2.2	-1.9	-2.1	-3.0	-0.8	-2.1
Medication: Ramipril	1.1	1.4	2.9	1.7	-0.2	0.7	1.2	0.8	1.6	1.7	1.2	0.7	1.1	-0.2	1.5	1.5	1.7	1.1	1.5	1.2	0.8	0.7	1.0
Trunk fat-free mass	1.1	6.4	14.4	1.6	2.3	0.8	2.0	3.6	3.8	1.2	3.1	1.0	1.4	2.8	3.1	3.0	2.1	2.1	3.2	2.2	3.5	1.1	3.1
Noisy workplace	1.1	1.4	5.4	1.1	0.7	-0.0	0.7	2.3	1.1	1.9	2.3	-0.1	-0.2	0.8	1.0	1.2	1.4	1.5	1.1	0.6	0.8	-0.2	-0.0
Illnesses of mother	1.1	1.4	4.9	-2.0	1.8	-0.8	-0.2	-0.0	-0.0	-2.2	-0.4	-1.2	-1.6	0.8	-1.4	-0.6	-1.6	-1.3	0.5	-1.2	-0.5	-1.0	-0.6
Impedance of arm (left)	1.1	5.3	21.6	-1.6	-2.2	0.2	-0.8	-4.7	-3.0	0.3	-4.0	0.2	0.3	-3.2	-2.2	-2.9	-2.4	-2.0	-2.0	-1.4	-2.8	0.1	-1.8
Trunk predicted mass	1.1	6.2	14.1	1.5	2.3	0.7	1.8	3.7	3.8	1.1	3.2	0.9	1.3	2.8	3.0	3.0	2.0	2.1	3.1	2.1	3.5	0.9	3.1
Hair/balding pattern: Pattern 4	1.1	2.6	7.2	-1.2	-1.0	-1.2	-1.8	-1.4	-2.2	-1.2	-1.5	-1.4	-1.3	-0.6	-2.0	-1.8	-1.4	-1.8	-2.7	-1.8	-1.9	-1.2	-1.6
Glaucoma (self-reported)	1.1	1.3	3.1	1.8	-1.4	0.7	0.5	0.8	1.1	0.8	0.9	0.7	1.1	0.5	1.2	0.9	1.6	1.6	1.4	0.9	1.3	0.6	1.6
Emphysema/chronic bronchitis	1.1	1.2	2.8	-0.7	-0.2	-1.4	-1.7	-0.1	-0.9	-0.9	-0.2	-1.3	-1.3	-1.1	-1.1	-0.9	-0.7	-1.5	-1.2	-1.3	-1.5	-1.4	-0.9
Leg fat mass (right)	1.1	4.4	7.7	1.7	1.6	2.0	1.7	1.3	2.8	2.1	1.9	1.8	1.8	2.0	2.4	2.5	2.0	2.1	2.2	2.4	2.5	2.0	2.4
Whole body fat-free mass	1.1	6.6	13.8	1.6	2.5	1.1	2.3	3.5	3.7	1.7	3.1	1.2	1.5	2.7	3.0	3.1	2.1	2.2	3.3	2.4	3.4	1.3	3.1
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.4	1.9	-0.8	0.8	1.2	0.6	1.5	0.7	1.0	0.8	1.1	0.5	1.2	1.6	1.8	1.3	0.9	1.3	1.2	0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	5.8	0.4	2.4	1.7	1.8	1.3	1.8	0.7	1.3	1.8	0.6	2.1	1.3	2.1	0.9	1.1	1.1	1.9	1.7	1.9	0.7
Whole body water mass	1.1	6.5	13.8	1.6	2.5	1.0	2.3	3.5	3.7	1.6	3.1	1.2	1.5	2.8	3.0	3.1	2.1	2.2	3.2	2.4	3.4	1.3	3.0
Supplements: Glucosamine	1.0	1.3	2.3	-1.2	-0.6	-0.7	-1.1	-0.9	-1.1	-1.4	-1.4	-1.1	-0.9	-0.4	-1.3	-1.5	-1.3	-1.2	-1.0	-1.4	-1.2	-0.9	-1.1
Medication: Lansoprazole	1.0	1.2	3.3	1.7	-0.6	-0.2	0.3	1.7	1.0	1.8	1.8	-0.1	0.4	0.3	1.2	1.2	1.7	1.1	0.6	0.6	0.9	-0.2	0.8
Number of full brothers	1.0	1.3	3.2	1.0	-0.2	1.7	1.4	-0.2	0.8	0.5	0.0	1.5	1.8	0.1	1.5	0.8	0.9	1.3	1.5	1.4	0.5	1.7	1.1
Angina (self-reported)	1.0	1.3	2.7	1.4	-0.1	1.3	1.2	0.7	1.0	0.9	1.2	1.1	0.9	1.0	1.1	1.3	1.5	1.6	0.8	1.5	1.0	1.1	0.9
Whole body fat mass	1.0	4.2	6.4	1.6	1.2	2.3	2.1	0.5	2.5	2.5	1.3	2.2	2.3	1.5	2.3	2.2	1.8	2.0	2.0	2.4	2.3	2.3	2.3
Medication: Aspirin	1.0	1.3	4.0	1.2	-0.3	1.6	1.5	0.4	0.7	1.8	0.8	1.2	1.0	1.0	0.9	0.8	1.4	2.0	0.7	1.2	0.8	1.2	0.4
Diabetes diagnosed by doctor	1.0	1.7	5.1	2.3	-1.2	0.4	-0.1	1.5	1.1	1.5	2.0	0.9	1.0	-0.0	1.5	1.2	2.2	1.8	0.9	1.2	1.0	0.5	0.9
Miserableness	1.0	1.7	4.9	0.8	1.1	1.1	1.5	0.2	2.2	1.2	0.7	1.0	1.3	0.9	1.5	1.5	0.8	0.9	1.6	1.3	2.1	0.9	1.5
Arm predicted mass (left)	1.0	5.0	12.1	1.1	2.6	0.7	1.6	3.4	3.5	0.7	2.9	0.8	0.9	2.6	2.5	2.7	1.7	1.8	2.9	1.8	3.0	0.8	2.6
Bipolar Disorder (2018)	0.9	1.4	6.1	-0.6	-1.9	0.0	0.1	-2.3	-1.0	0.4	-2.5	-0.1	1.2	-1.3	-0.6	-2.1	-1.3	-0.3	0.2	-0.8	-0.2	0.1	0.4
Waist Hip Ratio (WHR)	0.9	4.1	8.0	2.8	-0.5	1.9	1.6	1.4	1.5	1.3	1.7	2.2	2.4	0.7	2.5	2.2	2.8	2.6	1.1	2.7	2.2	2.2	2.1
Townsend deprivation index at recruitment	0.9	1.3	3.2	0.9	0.3	1.8	1.0	-0.3	1.1	-0.1	0.1	1.6	1.5	1.2	0.9	1.3	0.9	0.7	1.2	1.7	1.1	1.8	1.1
Average weekly fortified wine intake	0.9	1.0	5.0	0.2	-2.2	-0.9	-0.3	-0.9	-1.3	-1.5	-1.0	-1.2	-0.2	-0.7	-0.6	-1.0	-0.2	-0.7	-1.7	-1.0	-0.6	-1.0	-0.3
Trunk fat mass	0.9	4.0	6.1	1.5	1.3	2.4	2.1	0.1	2.4	2.5	1.0	2.2	2.4	1.1	2.3	2.1	1.6	1.7	2.0	2.4	2.1	2.4	2.4
Illnesses of siblings	0.9	1.3	4.2	-0.8	0.5	-1.8	-1.1	1.4	-0.2	-0.6	0.4	-2.0	-1.7	-0.5	-0.8	-0.4	-0.7	-1.4	-0.3	-1.3	-0.7	-2.0	-0.7
Impedance of arm (right)	0.9	4.1	16.6	-1.4	-1.9	0.2	-1.0	-4.1	-2.8	0.3	-3.5	0.3	0.2	-3.0	-1.9	-2.5	-2.0	-1.7	-1.9	-1.1	-2.5	0.2	-1.6
Asthma	0.9	1.8	6.2	1.8	-2.1	1.2	0.9	-0.5	-0.4	2.2	-0.0	1.4	1.5	1.6	0.7	0.1	1.5	2.5	-1.2	1.2	0.9	1.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.9	0.3	-1.5	-1.7	-1.3	0.5	-0.1	0.7	0.3	-1.9	-1.2	-0.6	-1.0	-0.7	0.0	-0.7	-0.2	-1.3	-0.9	-2.0	-0.9
Asthma (self-reported)	0.9	1.7	6.1	1.8	-2.1	1.1	0.8	-0.4	-0.4	2.0	0.1	1.3	1.4	1.5	0.6	0.2	1.6	2.5	-1.2	1.2	0.9	1.3	0.6
Smoking status: Current	0.9	1.5	3.6	1.8	-1.4	0.3	0.8	0.8	1.8	0.9	1.2	0.2	1.2	-0.5	1.6	1.1	1.6	0.9	1.9	0.9	1.0	0.2	1.6
Eye problems/disorders: Glaucoma	0.9	1.1	2.6	1.0	-0.4	0.8	0.8	0.6	1.3	1.1	0.6	1.0	1.1	0.3	1.1	0.9	1.0	1.3	1.6	1.0	1.4	0.8	1.6
Medication: Atorvastatin	0.9	1.1	2.6	1.6	-0.7	0.9	1.0	0.3	1.3	0.6	1.3	0.6	0.9	0.7	1.1	1.1	1.6	1.6	1.6	1.1	0.7	0.6	0.7
Illnesses of father: High blood pressure	0.9	1.1	3.6	1.1	-0.4	0.8	1.2	0.4	0.8	1.9	0.3	0.9	1.6	-0.3	1.4	0.8	0.9	0.9	0.9	1.0	1.4	0.9	1.5
Arm fat-free mass (left)	0.9	4.8	12.0	1.2	2.4	0.5	1.5	3.5	3.4	0.6	2.9	0.6	0.8	2.6	2.6	2.7	1.7	1.8	2.8	1.7	2.9	0.7	2.5
Number of operations (self-reported)	0.9	1.4	8.3	1.2	0.9	-0.3	-0.0	2.9	1.1	0.5	2.7	-0.1	-0.7	0.8	0.8	1.7	1.5	0.9	0.0	0.6	0.7	-0.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.6	0.9	1.3	0.7	0.9	1.8	1.3	-0.3	1.9	0.6	0.2	1.1	0.9	1.6	1.3	1.0	0.8	1.1	1.0	0.5	0.7
Leg fat mass (left)	0.9	3.6	6.0	1.4	1.7	1.8	1.6	1.1	2.5	1.9	1.7	1.7	1.7	2.1	2.1	2.2	1.7	1.9	1.8	2.1	2.4	1.9	2.2
Lupus	0.8	1.3	5.2	0.4	0.2	2.0	2.0	-0.7	0.6	2.3	-0.9	1.4	1.4	-0.0	0.3	0.5	0.3	0.5	1.0	1.1	0.0	1.8	0.5
Type 2 Diabetes (T2D) (2018)	0.8	1.4	4.5	2.1	-1.0	0.5	-0.1	1.2	0.9	1.9	1.8	0.8	0.8	-0.8	1.2	1.2	2.1	1.2	0.5	1.3	0.6	0.5	0.8
Diabetes (father)	0.8	1.0	2.9	1.1	0.8	0.8	0.7	1.1	1.5	1.1	1.6	0.7	0.3	1.0	1.1	1.7	1.3	0.9	0.6	0.9	0.8	0.6	0.3
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.8	0.8	0.8	0.4	0.5	1.3	1.3	-0.3	1.3	0.6	0.4	1.2	0.9	1.3	1.0	0.6	1.1	1.0	1.3	0.4	0.9
Diabetes (self-reported)	0.8	1.3	4.2	2.0	-1.1	0.1	-0.3	1.6	1.0	1.1	1.9	0.5	0.6	-0.7	1.3	1.2	2.0	1.3	0.7	0.9	0.4	0.1	0.6
Lung cancer (father)	0.8	1.0	3.2	-0.8	1.4	-1.3	-1.6	1.1	-0.3	-0.1	1.1	-1.1	-1.8	0.8	-0.9	0.2	-0.4	-0.9	-0.2	-0.8	-0.4	-1.2	-0.9
Birth weight of first child	0.8	1.5	10.4	-0.6	3.2	1.1	0.4	0.9	1.6	1.5	1.2	0.9	0.1	0.4	1.2	1.1	-0.1	0.9	1.7	0.9	0.9	0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.6	0.2	0.2	1.5	1.5	-1.2	0.1	1.2	-0.3	1.8	1.4	0.5	0.8	0.3	0.2	1.2	0.4	1.3	0.8	1.9	0.4
Gout (self-reported)	0.8	1.0	3.5	0.9	-0.2	1.1	1.0	0.4	1.0	1.4	0.0	1.1	1.5	-0.1	1.4	0.5	0.8	1.1	1.9	1.0	0.9	1.2	0.8
Medication: Ventolin 100micrograms inhaler	0.8	1.1	6.0	2.1	-2.4	-0.2	0.0	1.0	0.2	1.1	1.1	-0.3	0.5	0.1	0.8	0.3	1.9	1.5	-0.7	0.3	0.2	-0.2	0.4
Leg fat percentage (right)	0.8	2.8	4.1	1.6	1.0	1.8	1.2	0.5	2.0	1.6	1.3	1.8	1.8	1.1	2.0	2.0	1.8	1.7	1.4	2.0	1.9	1.9	2.0
Arm fat-free mass (right)	0.8	4.3	10.7	0.9	2.5	0.6	1.6	3.2	3.3	0.6	2.6	0.7	0.8	2.5	2.3	2.5	1.4	1.5	2.8	1.6	2.7	0.7	2.4
Wheeze or whistling in the chest in last year	0.8	1.4	3.9	2.0	-1.5	0.5	0.6	0.5	0.3	1.5	1.0	0.6	1.3	1.2	1.3	0.7	1.8	1.9	-0.7	1.0	1.3	0.7	1.1
Arm predicted mass (right)	0.8	4.0	10.6	0.9	2.4	0.7	1.6	3.0	3.3	0.6	2.4	0.7	1.0	2.4	2.3	2.4	1.4	1.5	2.6	1.6	2.7	0.8	2.4
Overall health rating	0.8	1.7	3.7	1.2	-0.0	1.5	1.7	0.6	0.7	1.7	0.7	1.7	1.4	1.3	1.3	1.0	1.3	1.9	0.7	1.7	1.3	1.6	1.1
Osteoporosis (self-reported)	0.8	1.0	3.3	-1.0	-0.0	0.0	0.1	-1.3	-1.6	0.5	-1.1	0.1	-0.7	1.8	-1.5	-1.2	-0.9	-0.1	-1.8	-0.6	-0.4	0.4	-1.4
Mother’s age at death	0.8	1.0	4.1	-1.5	2.0	1.2	1.1	-1.0	-0.4	-1.5	-1.2	1.0	0.2	1.0	-0.4	-0.2	-1.3	-0.8	-0.6	0.3	0.6	1.1	0.4
Alcohol drinker status: Previous	0.8	1.0	2.8	0.7	0.8	0.3	0.9	1.7	1.1	0.8	1.4	0.3	0.1	1.2	1.1	1.2	1.0	1.2	0.9	0.6	1.5	0.2	0.7
Bipolar Disorder or Schizophrenia	0.7	1.8	4.2	-1.0	-1.2	-1.8	-1.6	-0.1	-1.2	-0.9	-1.1	-1.9	-0.9	-1.2	-1.4	-2.0	-1.3	-1.1	-0.5	-2.0	-1.1	-1.8	-0.7
Hand grip strength (left)	0.7	1.8	6.2	1.6	-1.1	-1.6	-0.7	2.5	1.6	0.7	2.4	-1.8	-0.9	-0.1	1.0	1.2	1.6	0.6	1.0	-0.4	0.3	-1.9	0.3
Number of treatments/medications taken	0.7	1.3	4.2	0.3	1.3	2.0	1.1	0.2	0.6	1.1	-0.0	1.9	1.2	0.6	0.7	0.7	0.5	1.3	1.4	1.5	0.4	1.9	0.3
Relative age of first facial hair	0.7	1.3	4.5	-1.5	0.4	0.5	-0.3	-2.1	-1.0	-1.3	-1.9	0.4	-0.2	-0.7	-1.4	-1.2	-1.6	-1.7	-1.3	-0.4	-1.0	0.5	-0.9
Systolic blood pressure, automated reading	0.7	2.1	10.0	2.4	-3.2	1.5	1.0	-1.2	-0.4	1.8	-0.5	1.3	1.8	-0.8	0.8	0.2	1.8	1.3	-1.6	1.1	0.1	1.4	-0.1
Serious illness, injury or assault to yourself	0.7	0.9	3.8	1.2	-1.3	0.4	1.1	0.4	0.7	2.0	0.7	0.4	0.9	-0.9	0.9	0.3	1.1	1.3	1.4	0.7	-0.1	0.4	0.3
Stomach or abdominal pain in last month	0.7	0.8	3.0	-0.1	1.7	0.9	0.7	0.9	0.7	0.7	0.6	1.3	0.8	-0.1	1.2	1.0	0.2	0.9	0.9	1.1	0.7	1.2	0.8
Medication: Levothyroxine sodium	0.7	1.2	3.9	-2.0	1.5	0.1	-0.5	-0.5	-1.7	0.1	-1.1	0.5	-0.6	-0.4	-1.2	-1.4	-1.8	-0.8	-1.6	-0.6	-1.0	0.5	-0.8
High blood pressure (mother)	0.7	1.0	5.8	1.3	-2.4	0.5	0.2	-0.7	-0.2	1.8	-0.7	0.6	1.5	-1.0	1.0	-0.4	0.8	0.9	-0.0	0.3	0.2	0.6	0.4
Nervous feelings	0.7	1.3	3.5	1.2	0.4	0.4	0.8	1.5	1.0	1.3	1.3	0.5	0.6	1.6	1.1	1.4	1.2	1.3	1.9	1.0	1.4	0.2	1.4
Financial difficulties in last 2 years	0.7	0.9	3.0	-0.4	-0.3	-1.5	-1.7	0.5	-0.5	-0.7	-0.1	-1.7	-1.1	-0.7	-0.8	-0.7	-0.5	-0.9	0.3	-1.2	-0.8	-1.6	-0.7
Falls in the last year	0.7	1.0	5.6	-1.1	0.8	-1.4	-0.9	-0.1	-0.3	-0.7	0.1	-1.2	-1.1	2.4	-0.8	-0.7	-1.0	-0.2	-0.5	-1.1	0.8	-1.2	-0.2
Headache pain in last month	0.7	1.2	3.5	0.9	0.4	1.6	1.2	0.1	1.2	1.9	0.4	1.3	1.0	-0.2	1.2	1.4	1.1	0.9	0.7	1.5	0.5	1.4	0.5
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.7	1.3	-0.5	-0.6	-0.3	1.6	0.9	0.6	1.9	-0.5	-0.4	-1.1	0.4	1.0	1.3	0.3	1.0	0.2	-0.1	-0.8	0.1
High blood pressure (siblings)	0.7	1.1	3.0	0.4	-0.0	1.5	1.2	-1.2	0.2	1.2	-0.4	1.7	1.5	0.8	0.8	0.2	0.4	1.6	0.6	1.1	0.8	1.7	0.7
Qualifications: College or University degree	0.7	2.1	8.1	-0.7	-0.1	-2.8	-1.8	0.7	-0.1	-1.3	0.7	-2.5	-1.9	-0.4	-1.1	-0.5	-0.7	-1.9	0.3	-1.7	-0.6	-2.7	0.0
Suffer from ‘nerves’	0.7	1.0	3.0	1.7	-1.1	0.1	0.2	1.1	0.9	1.6	1.0	0.0	0.9	0.2	1.4	1.1	1.5	1.1	1.3	0.8	0.8	-0.0	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.8	-0.8	-0.7	-1.0	-0.5	-1.0	-0.8	-1.1	-0.9	-1.2	-0.8	-0.2	-0.9	-1.0	-0.9	-1.3	-1.0	-1.2	-0.8	-0.9	-0.7
Mineral and other dietary supplements	0.7	0.9	2.4	0.5	0.7	1.2	1.3	-0.3	1.1	0.8	0.3	1.5	1.1	0.0	0.8	1.0	0.5	0.5	1.0	1.2	0.9	1.4	1.1
Ever taken oral contraceptive pill	0.7	0.7	4.4	0.9	-0.6	-0.7	-0.6	1.3	1.0	0.6	1.1	-0.6	-0.2	-2.1	0.9	0.7	0.8	-0.1	0.8	0.0	-0.4	-0.9	0.1
Cholesterol lowering medication	0.7	1.0	2.4	1.2	-0.3	1.4	1.2	0.2	0.5	0.0	0.3	1.5	1.4	-0.3	1.0	0.9	1.1	0.8	0.2	1.5	0.9	1.4	1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.9	-1.2	0.0	-0.4	-0.0	-0.7	-1.2	0.0	-1.2	-0.6	-0.5	-1.4	-0.9	-1.2	-1.3	-1.2	-0.9	-1.0	-1.3	-0.6	-0.6
Pain experienced in last month	0.7	1.1	3.6	-0.2	-0.1	-1.9	-1.6	1.0	-0.1	-1.5	0.9	-1.5	-1.7	0.6	-1.2	-0.4	-0.1	-0.5	-0.1	-1.3	-0.0	-1.8	-0.5
Crohns Disease (2012)	0.6	1.0	6.1	-1.6	2.5	-0.3	-1.0	0.5	-0.6	-0.9	-0.0	-0.0	-1.0	-0.6	-1.0	-0.2	-1.3	-1.5	-0.8	-0.4	-0.6	-0.2	-0.7
Neuroticism (2016)	0.6	0.9	2.1	-0.9	0.9	-1.4	-1.2	1.0	0.1	-1.1	0.5	-1.2	-1.4	-0.5	-0.7	-0.2	-0.7	-1.3	0.4	-1.0	-0.5	-1.4	-0.5
Angina	0.6	0.8	1.8	1.0	0.2	1.0	0.8	0.7	0.9	0.6	1.1	0.7	0.5	1.2	0.8	1.2	1.2	1.4	0.6	1.1	0.9	0.8	0.7
Vitamin and mineral supplements	0.6	0.9	2.9	-0.4	-0.9	0.5	0.5	-1.7	-0.7	1.0	-1.6	0.9	0.9	-1.6	-0.2	-1.0	-0.8	-0.5	-1.2	-0.1	-0.5	0.8	-0.4
Current tobacco smoking	0.6	1.0	3.0	1.7	-1.7	-0.1	0.3	0.7	1.4	0.7	1.0	-0.2	1.0	-1.0	1.3	0.8	1.4	0.7	1.3	0.5	0.6	-0.2	1.4
Qualifications: CSEs or equivalent	0.6	0.9	3.4	-0.9	0.3	-1.1	-1.8	0.0	-1.2	-0.1	-0.2	-1.0	-0.9	-0.8	-1.1	-1.2	-0.9	-0.6	-0.1	-1.1	-1.1	-0.8	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	-1.5	1.4	0.8	0.4	-0.8	-0.9	-0.2	-1.1	0.2	-0.2	0.9	-0.7	-0.7	-1.3	-0.3	-0.6	-0.2	-0.6	0.6	-0.6
Medication: Atenolol	0.6	0.7	3.4	0.6	0.9	-0.3	-0.0	1.6	1.0	0.4	1.8	-0.1	-0.3	0.6	0.8	0.9	0.9	1.3	0.8	0.4	1.0	-0.4	0.2
Had other major operations	0.6	0.7	2.9	0.2	1.5	-0.1	0.3	1.7	0.7	0.1	1.6	0.1	-0.4	0.1	0.7	0.9	0.6	1.0	1.5	0.5	0.3	-0.1	0.4
Pulse rate	0.6	1.1	2.1	1.3	-0.7	1.5	1.2	0.4	0.9	1.4	0.2	1.4	1.2	0.5	1.2	1.0	1.3	0.9	0.5	1.3	0.7	1.4	0.5
Happiness	0.6	0.7	1.3	-0.5	-0.6	-1.0	-1.1	-0.5	-0.8	-0.6	-0.6	-1.0	-0.9	-0.6	-1.0	-0.8	-0.7	-0.7	-0.8	-1.1	-0.8	-1.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.4	-0.6	1.3	0.9	0.9	-0.7	0.9	1.0	-0.4	1.0	1.1	-0.1	0.9	0.1	-0.6	-0.1	0.3	0.6	1.3	1.0	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.1	0.8	-1.7	-1.4	-1.0	0.5	0.2	0.1	0.6	-1.5	-0.8	-0.9	-0.5	-0.3	0.5	-0.2	1.0	-0.9	-0.7	-1.8	-0.4
Medication: Amlodipine	0.6	0.8	3.4	1.9	-1.2	-0.3	0.1	1.3	0.4	0.6	1.7	0.0	0.1	0.4	0.9	1.2	1.8	0.8	0.4	0.5	0.3	-0.2	0.2
Body fat percentage	0.6	2.3	4.8	1.2	0.7	2.2	1.5	-0.7	1.5	2.1	0.3	2.0	2.0	0.7	1.6	1.4	1.2	1.3	1.1	1.9	1.4	2.1	1.6
Comparative body size at age 10	0.6	1.7	10.8	-0.4	3.3	-0.2	-0.0	2.6	1.7	-0.2	2.4	-0.3	-0.9	1.2	0.8	1.6	0.3	-0.2	0.5	0.3	1.1	-0.3	0.7
Medication: Ibuprofen	0.6	0.7	2.0	-1.4	1.3	0.6	0.0	-1.4	0.1	0.8	-1.4	0.5	0.6	-0.5	-0.1	-0.7	-1.4	-1.0	-0.2	-0.1	0.4	0.6	0.9
Ever had bowel cancer screening	0.6	0.7	3.8	-0.7	1.9	1.3	1.2	-0.4	0.5	0.5	-0.2	1.2	0.5	0.9	0.2	0.6	-0.4	-0.3	0.2	0.9	0.6	1.2	0.3
Friendships satisfaction	0.6	0.8	3.3	1.2	-1.8	-1.4	-1.1	0.2	0.3	-0.8	0.8	-1.2	-0.3	-0.7	0.3	0.2	0.9	-0.1	-0.6	-0.6	0.6	-1.5	0.7
Financial situation satisfaction	0.6	0.8	3.2	0.1	-1.5	0.8	0.4	-1.7	-0.7	-0.1	-1.8	0.5	1.1	-1.6	-0.3	-1.0	-0.3	-0.2	0.0	0.1	-0.5	0.7	0.2
Alcohol drinker status: Never	0.6	0.8	2.5	-0.3	-0.2	1.3	-0.2	-1.4	-1.2	0.2	-1.6	1.3	1.0	0.0	-0.5	-0.7	-0.4	0.2	-1.1	0.5	-0.3	1.5	-0.5
Leg fat percentage (left)	0.6	2.1	3.4	1.2	1.1	1.7	1.0	0.2	1.7	1.4	1.0	1.7	1.6	1.2	1.7	1.7	1.4	1.4	1.0	1.8	1.8	1.8	1.8
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.3	-0.7	0.7	-1.3	-0.9	0.9	-0.5	-0.9	0.4	-1.2	-1.1	-0.4	-0.5	-0.2	-0.6	-1.5	-0.6	-0.8	-0.0	-1.4	-0.1
Diastolic blood pressure, automated reading	0.6	1.8	12.1	2.5	-3.5	-0.0	0.0	0.3	-0.2	2.6	0.6	-0.2	0.7	-1.4	0.8	0.1	2.1	1.3	-1.1	0.2	-0.6	-0.1	-0.5
Alzheimer’s Disease (in father)	0.5	0.5	1.6	0.7	0.4	0.0	0.5	1.2	0.7	0.2	1.3	0.2	0.1	1.0	0.5	1.0	1.0	0.6	1.0	0.7	0.7	0.1	0.7
Blood Eosinophil Count	0.5	4.0	14.8	1.9	2.2	0.6	0.7	3.9	1.8	1.8	3.8	1.0	-0.3	0.5	2.2	3.5	2.7	1.5	1.1	2.2	0.6	0.8	0.6
Blood White Count	0.5	3.9	20.3	1.3	2.6	-1.2	-0.7	4.5	1.2	-0.4	4.2	-0.9	-2.1	1.8	1.0	3.1	2.3	0.3	-0.5	0.8	1.3	-1.2	-0.3
Lung FEV1/FVC ratio	0.5	2.3	20.4	-1.4	4.5	0.6	-0.4	1.8	0.8	-2.3	1.4	0.7	-1.5	1.6	-0.5	1.6	-0.4	-1.3	-0.6	0.7	0.4	0.6	-0.8
Average weekly spirits intake	0.5	0.6	2.2	0.4	0.7	0.2	0.9	1.0	1.2	-1.5	0.8	-0.0	0.5	0.3	1.0	1.0	0.5	0.0	0.6	0.5	1.0	0.1	0.8
Sensitivity / hurt feelings	0.5	0.9	3.1	0.2	1.3	-0.8	-0.5	1.8	0.8	-0.7	1.7	-1.0	-1.4	0.6	-0.3	1.1	0.6	-0.3	1.2	-0.1	-0.4	-1.1	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	4.3	0.5	1.1	-0.0	-0.2	1.3	1.5	0.1	1.3	0.0	-0.2	0.5	0.4	1.1	0.7	0.3	2.1	0.5	0.6	-0.2	0.3
Trunk fat percentage	0.5	2.1	5.5	0.8	0.7	2.3	1.6	-1.2	1.2	2.1	-0.2	2.1	2.1	0.2	1.3	1.1	0.8	1.0	1.0	1.7	1.0	2.2	1.5
Hand grip strength (right)	0.5	1.4	3.6	1.5	-0.5	0.1	0.6	1.5	1.9	1.5	1.6	0.1	0.5	1.2	1.5	1.3	1.5	1.2	1.3	0.7	1.2	0.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.6	1.1	-0.1	0.1	0.4	0.8	1.3	0.9	0.9	0.2	0.6	-0.7	1.0	1.2	1.1	0.4	1.2	0.7	0.5	0.1	0.5
Multivitamins +/- minerals	0.5	0.6	1.8	-0.1	0.9	-0.8	-1.0	1.1	0.3	-0.7	0.9	-1.4	-1.2	-0.1	-0.2	0.7	0.2	-0.8	0.6	-0.5	-0.5	-1.3	-0.2
Past tobacco smoking	0.5	0.9	3.0	-1.0	-0.1	-0.4	-0.3	-1.4	-1.2	0.6	-1.5	-0.4	-0.1	-1.3	-0.7	-1.3	-1.2	-0.9	-1.7	-0.9	-0.9	-0.2	-0.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	0.1	-1.4	-1.2	-0.7	0.3	-0.8	0.4	0.0	-1.4	-0.8	-0.5	-0.6	-0.9	-0.1	-0.1	-0.3	-1.1	-0.7	-1.4	-0.9
Exposure to tobacco smoke at home	0.5	0.5	1.8	0.6	0.2	0.2	0.8	0.6	0.7	0.7	0.9	0.5	0.3	1.0	0.9	0.7	0.7	1.3	1.1	0.7	0.8	0.4	0.4
Worry too long after embarrassment	0.5	0.8	3.1	-0.9	1.8	-1.2	-0.3	1.3	0.7	0.1	0.9	-1.2	-1.2	-0.4	-0.1	0.3	-0.6	-1.0	0.3	-0.9	-0.0	-1.4	0.0
Pulse rate, automated reading	0.5	1.6	8.2	2.1	-2.9	1.4	1.4	-0.2	0.1	1.7	-0.5	1.3	1.8	-0.1	0.7	0.4	1.6	0.9	-0.1	1.2	0.6	1.3	0.4
Alcohol intake frequency.	0.5	1.1	2.1	0.6	0.8	1.3	1.1	0.3	0.6	1.4	0.2	1.4	1.3	0.7	1.0	0.9	0.7	1.1	0.2	1.3	1.4	1.4	1.4
Number of full sisters	0.5	0.7	2.2	0.5	-1.5	-1.4	-1.0	0.7	-0.3	0.1	0.8	-1.2	-0.9	-0.7	-0.5	-0.6	0.3	0.1	0.2	-0.8	-0.6	-1.4	-0.5
Had major operations	0.5	0.5	2.6	0.1	0.7	-0.8	-0.3	1.6	0.5	-0.3	1.2	-0.9	-1.2	-0.3	-0.1	0.7	0.3	-0.6	-0.5	-0.3	-0.2	-1.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.9	0.8	0.1	-0.5	-0.0	1.7	2.0	1.3	1.3	-0.6	0.0	1.2	0.8	1.0	0.9	0.5	1.8	0.2	1.3	-0.6	0.9
Medication for cholesterol	0.5	0.8	2.8	0.6	-1.7	1.1	0.9	-1.5	0.0	1.1	-1.1	0.8	1.4	0.7	0.4	-0.4	0.3	1.0	0.4	0.4	0.5	1.1	0.7
Medication: Gliclazide	0.5	0.6	2.3	1.1	0.2	0.2	-0.3	1.0	1.1	-1.0	1.5	0.0	-0.1	0.3	0.6	1.3	1.3	0.4	-0.1	0.6	0.4	0.1	0.5
Risk taking	0.5	0.8	3.9	0.8	0.1	-0.3	0.3	1.4	1.4	0.6	1.4	-0.7	-0.2	0.5	0.8	1.0	1.0	0.6	2.0	0.2	0.6	-0.5	0.7
Alzheimer’s Disease (including proxy)	0.4	0.6	1.5	0.5	1.0	0.8	0.4	0.8	0.5	0.7	1.2	0.7	0.2	0.9	0.5	1.2	0.8	0.8	0.5	1.1	0.6	0.7	0.1
Crohns Disease (2017)	0.4	1.0	5.7	-0.6	2.4	-0.4	-1.2	1.9	0.2	-0.6	1.4	-0.1	-1.4	-0.1	-0.7	0.8	-0.1	-1.2	-0.5	0.0	-0.3	-0.4	-0.7
Irritable Bowel Disease (IBD)	0.4	0.9	3.1	-0.6	1.8	-0.3	-0.8	1.5	-0.3	-0.7	0.9	-0.3	-1.6	-0.4	-1.0	0.6	-0.2	-1.3	-1.5	-0.1	-0.8	-0.5	-1.3
Fasting Glucose	0.4	0.5	2.0	-0.1	1.4	0.7	0.5	0.5	0.8	0.8	0.6	0.6	0.4	0.9	0.4	0.4	0.2	-0.0	-0.1	0.5	1.1	0.5	1.2
Ever had hysterectomy (womb removed)	0.4	0.5	2.2	0.7	0.4	-0.2	-0.3	1.5	0.9	0.0	1.4	-0.3	-0.5	1.1	0.1	0.8	0.9	0.5	0.2	0.2	0.6	-0.4	0.0
Supplements: Zinc	0.4	0.5	1.3	1.1	-0.5	0.7	0.4	-0.1	0.7	0.3	0.5	0.2	0.5	1.1	0.7	0.8	1.1	1.0	-0.1	0.7	0.9	0.4	0.6
Age when periods started (menarche)	0.4	1.0	5.9	0.9	-2.4	1.3	1.1	-1.3	-0.8	1.0	-1.2	0.9	1.2	-0.5	-0.1	-0.6	0.6	0.9	-0.0	0.5	-0.6	1.1	-0.2
Hair/balding pattern: Pattern 2	0.4	0.5	2.4	0.1	-1.2	1.0	0.6	-1.4	-0.3	0.7	-1.5	0.6	1.1	-0.5	-0.0	-0.6	-0.3	0.0	0.1	0.3	-0.1	0.9	-0.3
Mouth/teeth dental problems	0.4	0.6	2.5	-0.4	-0.0	-1.3	-0.5	0.7	0.1	0.2	0.3	-1.6	-0.9	-0.4	-0.3	-0.3	-0.5	-0.9	-0.5	-1.0	0.1	-1.6	0.4
Allergy	0.4	0.8	3.5	-0.4	1.9	-0.6	-0.3	1.3	0.9	-1.3	1.3	-0.7	-1.1	-0.6	0.2	0.9	0.1	-0.9	1.5	-0.1	-0.3	-0.7	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.0	0.4	-1.3	0.6	0.4	-1.2	-0.8	1.4	-1.0	0.6	1.1	-0.7	0.1	-0.7	0.0	0.5	-0.6	0.1	0.1	0.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.0	1.3	-1.7	0.0	0.2	0.6	0.1	1.7	0.3	0.1	0.7	-1.3	0.7	0.2	1.0	0.4	-0.1	0.4	0.0	-0.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.6	0.2	1.9	-0.0	1.3	2.1	2.1	0.9	1.6	0.1	-0.3	0.7	1.1	1.9	0.6	-0.1	1.4	0.9	1.0	0.1	0.5
Tense / ‘highly strung’	0.4	0.6	2.5	-0.4	0.5	-1.0	-0.7	0.5	0.7	-1.1	0.3	-1.3	-0.9	-0.8	-0.4	0.1	-0.4	-1.2	0.6	-0.8	-0.1	-1.6	-0.0
Medication: Seretide 50 evohaler	0.4	0.5	5.6	0.6	-1.1	0.2	0.3	-0.4	-1.1	0.4	-0.2	0.2	0.2	-0.2	-0.2	-0.1	0.4	0.2	-2.4	0.3	-0.3	0.2	-0.5
Comparative height size at age 10	0.4	2.5	6.6	-2.2	1.2	-1.8	-1.3	-0.0	-0.2	-2.6	-0.9	-2.0	-1.5	-0.5	-1.5	-1.4	-2.1	-2.5	-0.6	-1.9	-1.1	-1.8	-0.6
Chest pain or discomfort	0.4	0.6	3.4	1.0	-1.8	-0.1	-0.2	-0.2	-1.1	1.1	-0.3	-0.1	0.3	-1.1	-0.1	-0.4	0.7	0.6	-1.5	0.2	-0.9	0.0	-0.6
Leg pain on walking	0.4	0.4	1.4	-0.8	1.1	-0.3	-0.3	0.3	-0.4	-0.4	0.2	-0.6	-1.2	1.2	-0.9	-0.2	-0.5	-0.1	-0.4	-0.4	-0.6	-0.4	-1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	4.7	-1.0	2.2	-0.0	0.1	1.3	0.4	0.6	0.6	0.1	-0.3	0.8	0.5	-0.0	-0.6	0.3	0.6	0.0	0.3	0.2	0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	2.7	-0.1	-0.5	0.5	0.2	-1.6	-0.8	-0.9	-0.9	0.6	0.2	1.0	-0.4	-0.2	-0.1	-0.0	-1.6	0.1	-0.1	0.8	-0.4
Average weekly red wine intake	0.4	0.6	1.8	-0.7	-0.9	-0.8	-0.7	-0.9	-1.3	-0.6	-1.0	-0.6	-0.1	-1.0	-0.7	-1.4	-1.0	-0.5	-0.2	-0.9	-0.7	-0.7	-0.1
Mood swings	0.4	0.8	2.7	0.7	0.8	-0.0	0.2	1.2	1.3	0.9	1.1	0.2	0.5	0.1	1.2	1.1	0.8	0.7	1.6	0.7	1.1	0.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.9	-0.7	0.7	0.6	0.1	-1.2	-0.4	0.7	-0.8	0.5	0.0	-1.4	-0.4	-0.5	-0.7	0.2	0.6	0.1	-0.6	0.6	-0.3
Qualifications: nursing, teaching	0.4	0.6	3.5	-0.5	1.2	0.2	0.9	-0.2	1.5	0.4	0.0	0.0	0.5	0.1	0.7	0.4	-0.4	0.0	1.9	0.3	0.8	0.1	0.9
Commuting to job workplace: Walk	0.4	0.4	1.4	0.4	-0.0	-1.2	-0.0	1.1	0.7	-0.0	1.0	-0.6	-0.4	1.0	0.4	0.5	0.4	0.5	0.8	-0.3	0.7	-0.9	0.2
Eye problems/disorders: Cataract	0.4	0.5	2.1	0.3	0.7	-0.4	-1.2	1.4	-0.3	-0.9	1.2	-0.2	-0.8	0.4	-0.5	0.4	0.5	0.4	-0.2	0.1	-0.8	-0.2	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	1.8	-0.5	-0.8	-0.3	-0.9	-1.0	-1.2	0.2	-0.9	-0.4	-0.3	-0.6	-1.1	-1.1	-0.6	-0.4	-0.7	-0.7	-1.4	-0.2	-1.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.5	-0.1	1.2	0.3	0.1	1.5	0.9	0.3	1.1	0.2	-0.2	0.2	0.7	0.5	0.2	0.7	1.6	0.4	0.2	0.1	0.2
Medication: Bendroflumethiazide	0.4	0.6	2.0	0.3	-0.3	0.8	0.8	-0.9	0.2	1.4	-0.5	1.0	1.4	-0.4	1.2	-0.1	0.0	0.8	0.1	0.5	0.9	0.9	0.8
Basal cell carcinoma (self-reported)	0.4	0.4	1.6	-0.4	-0.6	-0.1	-0.7	-1.2	-1.0	0.1	-1.1	-0.4	-0.0	-0.1	-0.8	-0.9	-0.6	-0.4	-1.1	-0.7	-0.3	-0.3	-0.2
Heart disease (siblings)	0.4	0.4	1.3	-0.5	-0.1	-0.5	-0.9	-0.0	-0.5	-0.9	0.3	-0.6	-1.0	1.1	-0.8	-0.4	-0.3	-0.2	-1.1	-0.7	-0.3	-0.6	-0.9
Depression (Nagel 2018)	0.3	0.5	2.5	0.5	0.9	0.3	0.4	0.8	1.4	0.4	1.0	0.3	0.0	0.0	0.4	1.1	0.7	0.2	1.6	0.6	0.5	0.2	0.1
Intelligence (Savage-Jansen 2018)	0.3	0.8	3.4	-0.1	-1.8	-0.3	-0.2	-1.8	-0.7	-0.3	-1.5	-0.1	0.8	-1.2	-0.2	-0.9	-0.6	-1.1	-1.5	-0.4	-0.3	-0.2	0.6
Worry (Nagel 2018)	0.3	0.6	1.6	-0.8	1.1	-1.0	-1.2	1.0	-0.4	-0.7	0.2	-1.0	-1.1	-0.2	-0.5	-0.3	-0.7	-0.5	0.4	-0.8	-0.5	-1.3	-0.2
Alzheimer’s Disease (in mother)	0.3	0.3	1.3	0.3	1.2	0.3	-0.1	0.6	0.3	0.7	1.0	0.4	-0.2	0.6	0.1	1.0	0.5	0.4	-0.0	0.7	0.3	0.3	-0.4
Ulcerative Colitis (UC)	0.3	0.6	2.7	-0.7	1.1	-0.0	-0.2	0.6	-0.5	-0.7	0.1	-0.3	-1.2	-0.1	-0.9	0.3	-0.5	-0.9	-1.7	-0.2	-0.8	-0.3	-1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.7	3.4	0.3	-1.8	0.5	0.6	-1.4	-0.2	0.6	-1.2	0.6	1.3	0.5	0.2	-0.4	-0.1	-0.1	-1.3	0.2	0.8	0.7	0.8
HDL Cholesterol	0.3	0.4	2.5	-1.5	1.6	0.4	-0.1	-0.2	-0.4	-0.2	-0.7	0.2	-0.4	0.7	-0.6	-0.3	-1.3	-0.5	-0.0	-0.1	0.1	0.3	-0.3
Rheumatoid Arthritis	0.3	0.5	3.9	0.3	-0.4	-0.4	-1.4	-0.2	-0.2	0.6	0.4	-0.5	-0.8	0.7	-0.5	-0.0	0.4	-0.1	-2.0	-0.4	-0.2	-0.4	-0.6
Schizophrenia (2014)	0.3	0.7	1.5	-1.0	0.6	-1.0	-1.1	0.5	-0.6	-0.7	0.0	-1.2	-1.1	0.3	-1.0	-0.9	-0.8	-0.5	-0.5	-1.2	-0.5	-1.0	-0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.8	-0.3	-0.1	-0.4	-0.4	-1.4	-0.9	0.6	-1.0	0.4	0.4	-0.7	-0.2	-0.7	-0.5	-0.4	-1.0	-0.1	-0.1	0.3	-0.1
Blood Platelet Count	0.3	3.2	13.2	-1.6	0.6	-1.1	-1.5	-0.0	-3.3	-0.5	-0.4	-0.9	-2.2	-0.7	-2.0	-1.1	-1.4	-1.6	-3.6	-1.1	-2.5	-0.8	-3.2
Respiratory disease	0.3	0.8	3.3	0.4	-0.9	1.0	0.2	-1.0	-0.9	0.7	-0.7	1.0	0.8	1.8	-0.2	-0.4	0.3	1.1	-1.3	0.6	0.5	1.1	0.1
Chronotype (morning person)	0.3	0.7	1.9	1.0	0.2	0.3	0.6	1.2	0.9	0.2	1.1	0.5	0.2	1.4	0.5	1.0	1.2	1.2	0.8	0.9	1.1	0.3	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.7	-0.2	1.2	-0.2	0.3	1.3	0.7	-1.2	0.8	-0.3	-0.5	0.3	0.0	0.6	0.0	-0.5	0.7	0.1	0.3	-0.2	0.3
Diabetes (mother)	0.3	0.4	2.0	-0.0	-0.5	0.2	-0.5	-0.5	-0.9	0.6	-0.6	0.3	0.4	1.4	-0.2	-0.8	-0.2	0.3	-1.3	-0.2	0.3	0.3	-0.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	4.2	0.4	-2.0	0.1	0.2	-1.4	-0.6	1.4	-1.2	0.2	0.9	-0.3	-0.2	-0.9	-0.1	0.3	-1.2	-0.3	0.1	0.2	0.1
Pain all over the body in last month	0.3	0.3	0.8	0.6	-0.7	0.9	0.8	-0.2	-0.1	0.1	-0.6	0.7	0.9	-0.9	0.3	0.2	0.4	0.1	0.6	0.8	-0.4	0.9	-0.0
Fluid intelligence score	0.3	0.6	3.4	0.4	-1.8	0.5	0.4	-1.5	-0.3	0.6	-1.3	0.7	1.2	-0.1	0.2	-0.4	-0.1	-0.1	-0.6	0.3	0.4	0.7	0.5
Hip circumference	0.3	1.1	2.5	0.3	1.5	1.0	1.2	0.2	1.2	1.6	0.8	0.8	0.8	1.1	1.0	1.1	0.6	0.8	1.0	1.1	1.4	1.0	1.5
Mouth/teeth dental problems: Dentures	0.3	0.5	3.0	0.1	-0.5	-0.4	-1.1	0.1	-0.7	-1.7	-0.0	-0.1	-0.6	-0.1	-0.8	-0.3	0.1	0.0	-0.9	-0.3	-0.7	-0.2	-1.2
Breastfed as a baby	0.3	0.3	3.5	0.8	-1.9	-0.4	-0.1	-0.1	-0.2	0.1	-0.0	-0.4	0.0	-1.0	0.2	-0.4	0.5	0.2	-0.3	-0.3	-0.1	-0.6	-0.1
Peak expiratory flow (PEF)	0.3	0.7	1.9	-0.9	1.2	-1.1	-0.7	0.5	0.3	-0.6	0.5	-1.1	-1.4	-0.6	-0.6	0.1	-0.7	-1.2	-0.1	-0.7	-0.7	-1.0	-1.3
Forced vital capacity (FVC), Best measure	0.3	1.2	3.9	0.4	1.2	0.1	1.5	1.7	2.0	1.3	1.2	0.1	0.1	0.8	1.1	1.6	0.7	0.3	1.8	0.9	1.0	0.2	0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	2.9	0.1	-1.2	-0.4	0.3	-0.1	-0.5	-0.7	-0.4	-0.3	-0.0	-1.7	0.2	-0.5	-0.1	-0.5	0.1	-0.4	-1.0	-0.5	0.0
Medication: Allopurinol	0.3	0.4	2.9	0.3	0.2	0.4	0.5	0.5	0.5	0.9	0.0	0.3	0.5	-1.0	0.8	0.2	0.3	0.4	1.7	0.3	-0.1	0.3	0.1
Medication: Omeprazole	0.3	0.4	0.8	-0.6	-0.3	-0.3	0.1	-0.5	-0.9	-0.1	-0.7	-0.4	-0.4	-0.8	-0.6	-0.9	-0.7	-0.7	-0.7	-0.6	-0.9	-0.4	-0.5
Loneliness, isolation	0.3	0.5	1.1	0.8	-0.9	-0.5	-0.1	0.3	0.9	1.1	0.5	-0.2	0.4	0.4	0.9	0.3	0.6	0.7	0.9	-0.0	1.0	-0.4	0.9
Guilty feelings	0.3	0.4	1.5	0.2	0.2	-0.6	-0.7	1.2	0.8	0.0	0.7	-0.8	-0.2	-0.9	0.7	0.6	0.3	-0.4	1.0	-0.2	0.2	-0.9	0.4
Commuting to job workplace: Public transport	0.3	0.3	1.5	1.1	-1.2	-0.3	0.3	0.6	-0.2	0.6	0.8	-0.3	-0.1	-0.2	0.3	0.6	1.0	0.6	0.1	0.2	-0.3	-0.4	0.1
Ever smoked	0.3	0.5	1.8	0.5	0.2	-0.2	-0.5	1.3	0.6	-1.1	1.2	-0.0	-0.3	1.1	0.2	0.8	0.7	0.0	0.9	0.3	0.6	-0.3	0.1
Age started oral contraceptive pill	0.3	0.4	2.0	-0.6	1.1	0.8	0.5	-0.4	-0.4	-1.4	-0.5	0.8	0.0	0.7	-0.2	0.2	-0.4	-0.5	-1.2	0.3	0.4	0.7	-0.1
Breast Cancer	0.2	0.5	1.8	-0.7	-0.2	0.6	1.1	-1.2	-0.5	-0.6	-1.3	0.5	0.8	-0.8	-0.1	-0.9	-0.9	-0.1	0.8	0.1	-0.4	0.7	0.2
Bipolar Disorder (2011)	0.2	0.2	1.9	-0.5	-0.2	-0.1	0.0	-0.4	0.1	-0.2	-0.7	-0.2	0.1	-1.4	-0.2	-0.5	-0.7	-0.5	0.2	-0.5	-0.4	-0.2	-0.0
LDL Cholesterol	0.2	0.4	1.3	1.1	-1.2	-0.1	0.4	0.3	-0.1	0.9	0.4	0.3	0.6	-0.1	0.6	0.3	0.9	0.7	-0.7	0.4	0.5	0.0	0.6
Blood Red Count	0.2	1.5	5.7	-1.5	0.5	1.2	-0.1	-2.4	-1.4	1.2	-2.4	1.1	1.1	-0.9	-0.4	-1.6	-1.7	-0.2	-0.6	-0.0	-0.5	1.4	0.1
Heel T-Score	0.2	1.5	4.2	-1.8	0.1	-1.4	-1.6	-1.0	-0.5	-0.2	-1.4	-1.4	-0.7	-1.3	-0.7	-1.9	-2.1	-1.1	-0.3	-1.8	-0.7	-1.2	-0.4
Allergy or Eczema	0.2	0.5	3.3	0.4	-1.7	-0.1	0.3	-0.7	-0.3	1.8	-0.5	0.1	0.6	0.2	0.1	-0.8	0.1	0.7	-0.8	-0.3	0.4	0.0	0.4
Lung FVC	0.2	1.2	3.8	1.1	-0.4	-0.3	1.9	1.9	1.1	1.5	1.7	-0.2	-0.3	0.4	1.1	1.3	1.3	1.1	1.5	0.6	0.3	-0.4	0.1
Neuroticism	0.2	0.5	1.6	-0.4	0.4	-1.1	-1.2	0.9	-0.4	-0.2	0.6	-1.0	-1.2	0.2	-0.5	-0.2	-0.2	-0.1	0.0	-0.8	-0.3	-1.3	-0.6
Tanning	0.2	2.1	4.8	-1.2	-1.0	-1.0	-1.2	-1.4	-1.6	-1.5	-1.5	-1.4	-1.0	-2.1	-1.6	-1.7	-1.4	-1.7	-0.5	-1.6	-2.2	-1.1	-1.4
Medication: Co-codamol	0.2	0.2	2.0	-0.4	1.4	0.6	0.3	0.0	0.5	0.3	-0.2	0.5	0.4	0.3	0.1	0.3	-0.3	-0.3	-0.5	0.4	0.6	0.6	0.3
Fed-up feelings	0.2	0.4	1.5	0.4	-0.2	1.0	0.8	-0.7	0.6	-0.0	-0.6	0.5	1.1	0.1	0.5	0.3	0.2	0.4	1.2	0.6	0.8	0.7	0.8
Sitting height	0.2	1.2	6.9	-0.2	1.8	-0.6	0.4	1.7	1.8	-0.8	1.1	-0.2	-0.1	0.8	0.7	1.0	0.0	-0.0	2.6	0.4	1.1	-0.4	1.5
Number of incorrect matches in round	0.2	0.3	1.5	-0.1	0.8	1.1	-0.3	-0.6	-0.2	-0.4	-0.4	0.9	0.4	1.2	-0.1	0.2	-0.0	0.2	0.2	0.5	0.4	1.0	0.3
Forced vital capacity (FVC)	0.2	0.7	3.6	0.5	0.1	-0.7	0.8	1.5	1.6	0.8	1.0	-0.7	-0.2	-0.3	0.7	1.0	0.5	-0.2	1.9	0.2	0.3	-0.6	0.4
Neuroticism score	0.2	0.5	1.6	0.1	0.6	-1.0	-0.7	1.3	0.8	0.6	1.0	-0.8	-0.5	-0.3	0.4	0.5	0.2	-0.0	1.0	-0.4	0.6	-1.2	0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	3.4	0.2	1.1	-0.6	0.5	1.8	1.7	0.3	1.4	-0.5	-0.6	0.1	0.7	1.3	0.4	-0.3	1.7	0.2	0.4	-0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.2	-0.9	0.7	-1.1	-0.5	0.4	-0.1	0.3	0.1	-0.7	-0.8	0.6	-0.3	-0.3	-0.9	-1.0	-0.4	-0.8	0.3	-1.0	0.2
Prospective memory result	0.2	0.3	2.0	0.3	0.2	-0.7	-0.8	1.4	0.1	0.0	1.1	-0.5	-0.5	-0.2	0.0	0.1	0.5	0.0	-0.3	-0.3	0.1	-0.6	-0.1
Loud music exposure frequency	0.2	0.2	1.0	0.1	-0.2	-0.3	0.7	0.7	-0.7	1.0	0.2	-0.2	-0.2	0.0	-0.1	-0.1	0.1	-0.2	-0.6	-0.1	-0.5	-0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.7	-0.2	-0.6	-0.1	-0.4	-0.5	-0.2	1.1	-0.7	-0.2	0.2	-1.3	0.1	-0.5	-0.4	-0.4	0.1	-0.4	-0.3	-0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.3	-1.2	0.6	-0.0	-0.6	-0.3	-1.0	0.4	-0.9	0.3	-0.3	-0.4	-0.7	-0.9	-1.1	-0.5	-0.7	-0.4	-0.8	0.3	-0.8
Medication for pain relief, constipation, heartburn	0.2	0.3	1.0	0.1	0.0	-1.0	-0.9	0.7	-0.1	-0.8	0.8	-0.7	-1.0	0.0	-0.3	0.3	0.2	-0.2	0.1	-0.4	-0.4	-0.8	-0.6
Neck or shoulder pain in last month	0.2	0.3	4.0	0.2	-0.2	0.2	0.6	0.7	-0.3	2.0	0.2	-0.1	0.0	-0.0	0.4	0.2	0.2	0.4	-0.4	0.2	-0.3	0.1	-0.4
Heart disease (mother)	0.2	0.3	0.9	0.4	-0.4	0.5	0.4	0.1	-0.0	0.9	-0.1	0.6	0.6	-0.8	0.5	0.3	0.3	-0.1	-0.9	0.6	-0.1	0.6	-0.3
Family relationship satisfaction	0.2	0.3	1.7	0.1	-1.3	-0.6	-0.6	-0.7	0.2	-0.1	-0.7	-0.6	0.2	0.1	-0.2	-0.7	-0.3	-0.2	-0.1	-0.7	0.4	-0.6	0.4
Knee pain experienced in last month	0.2	0.2	2.2	-0.7	1.5	0.4	0.4	0.4	0.1	-0.4	0.1	0.5	0.0	0.6	0.3	0.4	-0.4	-0.2	-0.0	0.5	0.1	0.5	-0.0
Breast cancer (self-reported)	0.2	0.2	2.0	-0.5	0.7	0.4	0.4	0.0	0.1	0.5	0.1	0.7	0.2	-1.4	0.4	-0.0	-0.4	-0.0	-0.2	0.3	0.0	0.4	-0.3
Medication: Blood pressure	0.2	0.3	2.0	0.2	0.8	-0.3	0.2	1.4	0.7	-0.2	1.1	-0.2	-0.2	-0.3	0.8	0.7	0.4	0.1	0.4	0.1	0.4	-0.3	0.2
Irritability	0.2	0.4	1.1	0.4	0.3	0.7	0.5	-0.1	1.1	0.1	0.1	0.8	0.8	-0.1	0.7	0.7	0.4	-0.2	0.6	0.8	1.0	0.5	0.7
Fractured/broken bones in last 5 years	0.2	0.3	1.1	-0.4	-0.2	-0.4	-0.3	-0.5	-0.4	0.2	-0.4	-0.3	-0.6	0.9	-1.0	-0.6	-0.4	-0.4	-1.0	-0.7	0.1	-0.4	-0.2
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	0.4	-0.1	0.8	0.4	-0.6	0.5	0.6	-0.3	0.7	0.9	0.2	0.4	0.3	0.3	0.4	0.6	0.6	0.7	0.7	0.5
Neuroticism (Nagel 2018)	0.1	0.2	1.6	-0.3	1.3	0.0	-0.1	0.6	0.5	-0.4	0.3	-0.1	-0.2	-0.1	0.1	0.5	-0.1	-0.3	1.1	0.1	0.1	-0.3	0.3
HbA1C	0.1	0.1	0.5	-0.3	0.7	-0.2	-0.2	0.3	0.7	0.2	0.2	-0.2	0.0	0.1	0.6	0.2	-0.2	0.3	0.6	-0.2	-0.1	-0.0	0.2
Height	0.1	2.3	11.3	-1.2	3.4	0.9	1.8	0.6	2.5	-0.2	-0.0	0.8	1.0	0.8	1.2	1.2	-0.9	-0.7	2.7	0.9	1.7	0.9	2.1
Smoking Status	0.1	0.3	0.8	0.9	-0.9	0.2	-0.0	0.4	0.6	-0.6	0.5	-0.3	0.3	-0.4	0.3	0.5	0.8	0.0	0.9	0.3	-0.1	-0.2	0.3
Hypothyroidism (self reported)	0.1	0.2	0.6	-0.7	0.4	-0.3	-0.8	0.1	-0.4	0.1	-0.4	-0.1	-0.5	-0.1	-0.6	-0.7	-0.6	-0.1	0.3	-0.4	-0.6	-0.1	-0.7
Pack years adult smoking proportion	0.1	0.1	0.4	0.2	0.4	0.2	0.0	-0.0	-0.1	-0.1	0.2	0.4	0.4	-0.7	0.4	0.3	0.3	-0.1	-0.3	0.4	-0.4	0.4	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	1.3	-0.6	1.1	0.4	0.1	-0.2	-0.1	0.6	-0.5	0.0	0.5	0.8	0.1	-0.1	-0.5	-0.0	0.4	0.1	0.4	0.4	0.9
Chronic bronchitis/emphysema (father)	0.1	0.1	0.7	0.1	0.4	0.1	-0.1	0.8	-0.1	-0.2	0.4	0.0	-0.2	-0.0	0.3	0.2	0.2	0.7	-0.4	0.1	0.2	-0.0	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	1.1	0.3	-0.1	-0.4	-0.0	-0.1	0.4	1.1	0.3	-0.7	-0.2	0.2	0.2	0.2	0.2	0.2	0.6	-0.2	0.1	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.1	-0.2	0.0	0.7	0.2	-1.0	-0.3	0.4	-0.9	0.4	0.9	0.7	-0.0	-0.3	-0.4	0.1	0.0	0.3	0.6	0.6	0.9
Hair/balding pattern: Pattern 3	0.1	0.2	0.7	0.2	0.1	-0.4	0.7	0.6	0.7	-0.0	0.9	0.0	-0.0	-0.3	0.7	0.3	0.2	0.6	0.4	-0.0	0.5	-0.3	0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.1	0.3	0.1	-0.1	0.2	-0.5	-0.2	0.4	0.3	-0.4	-0.4	-0.0	0.3	0.2	0.1	-0.4	0.3	-0.5	0.1	-0.5
Standing height	0.1	0.9	4.0	-0.6	1.5	0.4	1.1	0.2	1.7	0.0	-0.4	0.5	0.9	-0.0	0.8	0.5	-0.6	-0.4	2.0	0.5	1.0	0.6	1.6
Medication: Paracetamol	0.1	0.1	0.5	-0.1	0.1	0.4	0.6	-0.0	0.5	0.4	-0.1	0.2	0.3	0.7	0.4	0.1	-0.0	0.3	0.2	0.2	0.2	0.4	0.0
Age at first live birth	0.1	0.2	1.2	0.2	-0.3	-0.6	-0.1	-0.2	-0.2	0.1	0.3	0.0	-0.2	1.1	-0.2	0.2	0.2	-0.2	-1.0	0.0	0.8	-0.2	0.3
Pulse wave peak to peak time	0.1	0.1	0.5	-0.1	-0.2	-0.1	0.3	-0.1	0.6	0.1	-0.4	-0.3	0.4	0.5	0.1	-0.2	-0.2	-0.1	0.7	-0.2	0.5	-0.0	0.6
Migraine (self-reported)	0.1	0.2	1.4	0.5	-0.2	0.1	-0.3	0.2	0.9	-0.2	0.2	-0.3	-0.1	-0.4	0.1	0.4	0.4	-0.1	1.2	0.1	-0.3	-0.3	-0.4
Smoking status: Previous	0.1	0.2	0.7	0.3	0.4	0.2	-0.2	0.7	0.2	-0.7	0.8	0.1	-0.4	0.8	-0.1	0.6	0.5	0.3	0.8	0.3	0.1	-0.0	-0.2
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.0	-0.1	-0.0	0.4	-0.6	0.6	0.1	-0.3	-0.1	0.3	-0.2	0.1	0.2	-0.1	-0.6	0.3	0.0	0.1	0.0	0.7
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.6	0.2	-0.5	-0.3	-0.1	0.3	-0.1	-0.8	0.2	-0.6	-0.3	0.2	0.3	0.0	0.3	0.4	0.2	-0.2	-0.0	-0.5	-0.1
Medication: Paracetamol	0.1	0.1	0.6	-0.3	-0.0	0.4	0.2	-0.3	0.0	0.8	-0.8	0.0	0.2	0.0	-0.2	-0.4	-0.4	-0.2	0.3	-0.1	-0.6	0.3	-0.2
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.4	0.5	-0.0	-0.1	-0.6	-0.7	0.1	-0.4	-0.5	-0.3	0.0	-0.3	-0.2	-0.3	0.2	-0.4	-0.2	-0.5	-0.2	-0.7
Commuting to job workplace: Cycle	0.1	0.2	0.6	-0.1	0.1	-0.4	-0.5	-0.7	0.2	-0.1	0.1	-0.5	-0.4	0.5	-0.5	0.2	-0.1	-0.6	-0.8	-0.4	0.5	-0.5	-0.0
Pack years of smoking	0.1	0.2	1.0	-0.1	0.8	0.2	-0.2	-0.2	-0.3	-0.6	0.1	0.4	0.1	-0.7	0.1	0.3	0.1	-0.5	-1.0	0.3	-0.6	0.4	-0.0
Hair Pigment	0.0	1.3	4.8	0.3	2.2	0.4	0.7	2.1	1.6	0.3	1.8	0.7	-0.2	-0.5	1.2	2.1	0.8	-0.1	0.7	1.2	0.1	0.4	0.3

Hub : Genes

MXI1

Models

Trait associations