Hub : Genes

MYO5B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0665	0.0251	0.00200	0.008	0.017	0.012	0.017	0.014	1.8e-02	0.00130	5.6e-03	0.0011	2.9e-03
2	TCGA	Breast Invasive Carcinoma	0.0328	0.0154	0.00320	0.002	0.007	0.014	NA	0.007	1.2e-01	0.01300	5.7e-04	NA	9.1e-03
3	TCGA	Brain Lower Grade Glioma	0.0672	0.0286	0.00072	0.032	0.012	0.004	NA	0.017	1.4e-04	0.01400	9.0e-02	NA	4.5e-03
4	TCGA	Lung Squamous Cell Carcinoma	0.0645	0.0295	0.01000	-0.002	0.014	0.014	NA	0.001	6.4e-01	0.00900	9.4e-03	NA	2.4e-01
5	TCGA	Pancreatic Adenocarcinoma	0.1400	0.0670	0.00850	0.000	0.010	0.057	NA	0.014	3.0e-01	0.12000	2.1e-03	NA	8.1e-02
6	TCGA	Thyroid Carcinoma	0.0700	0.0280	0.00120	0.058	0.032	0.044	NA	0.047	2.7e-06	0.00039	3.5e-05	NA	2.2e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	1.0	2.1	1.5	-1.3	-0.7	-0.2	-0.2	-1.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.7	-0.6	-0.3	-0.8	0.4	0.5
Depressed Affect (Nagel 2018)	0.3	0.6	2.3	-1.5	0.0	-0.2	-0.8	-0.6	0.6
Depression (Nagel 2018)	0.4	0.6	1.3	-0.9	1.1	0.6	-0.9	0.4	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.1	0.7	-1.1	-0.3	-0.2	-0.1	-0.8
Neuroticism (Nagel 2018)	0.3	0.8	1.8	-0.3	1.1	0.6	-1.4	-1.1	-0.1
Schizophrenia (2018)	0.3	0.6	2.4	-0.3	0.2	0.2	-0.8	0.7	1.6
Schizophrenia vs Biploar Disorder	1.0	1.4	3.1	-1.8	-0.8	-0.6	0.4	1.6	1.3
Worry (Nagel 2018)	0.3	0.6	2.2	-0.2	0.9	0.2	-1.5	-0.8	-0.0
Alzheimer’s Disease (in mother)	0.6	0.7	1.8	-0.1	0.8	0.3	-1.2	-1.3	-0.2
Alzheimer’s Disease (in father)	0.9	0.9	3.5	1.9	-0.3	-0.5	0.3	0.0	-1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.1	1.0	0.7	-0.1	-0.3	-0.9	-0.3
Crohns Disease (2017)	0.0	0.1	0.2	-0.2	-0.2	-0.4	0.3	-0.4	0.3
Irritable Bowel Disease (IBD)	0.8	1.8	3.1	-1.3	-1.6	-1.8	0.6	1.7	0.4
Ulcerative Colitis (UC)	1.7	3.2	6.7	-1.5	-2.3	-2.2	0.4	2.6	0.2
Major Depression (MDD)	0.3	0.3	1.1	-0.8	0.4	-1.0	-0.3	-0.2	0.0
Reaction Time	0.9	1.7	4.6	0.5	-0.8	-0.3	-1.7	-2.1	-1.3
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	-0.7	-1.1	-1.3	0.1	-0.1	-1.0
Breast Cancer	0.1	0.2	0.6	-0.3	0.4	-0.2	0.2	0.8	-0.4
Ovarian Cancer	0.9	1.1	4.3	-0.3	0.0	0.5	-0.2	-1.5	2.1
Prostate Cancer	0.8	1.1	4.5	-0.1	-0.3	-0.6	0.8	2.1	1.0
Age at First Birth	0.3	0.4	1.5	0.2	-1.2	0.4	0.2	-0.0	-0.7
Bipolar Disorder (2011)	0.4	0.3	0.9	0.9	-0.2	-0.1	-0.3	0.4	0.9
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	-0.4	-0.1	0.0	-0.0	0.9	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	0.8	-0.3	0.6	-0.9	-0.2	-0.1	-0.9
Crohns Disease (2012)	0.3	0.4	1.5	0.8	-0.4	-0.3	-0.3	-1.2	-0.3
Mean Putamen Volume	0.7	0.8	1.7	0.5	1.1	0.8	1.3	0.6	0.8
Fasting Glucose	0.5	0.6	1.4	0.1	1.0	0.1	0.6	1.2	1.0
HbA1C	0.2	0.2	0.6	-0.3	0.2	0.4	0.4	0.3	0.7
HDL Cholesterol	4.3	7.1	24.0	4.9	3.5	1.9	-0.2	-1.2	1.0
LDL Cholesterol	0.8	1.3	5.6	2.4	0.9	0.9	-0.1	-0.6	-0.5
Lupus	0.2	0.3	0.6	-0.2	0.7	0.8	0.6	-0.6	-0.0
Neuroticism (2016)	0.5	0.7	3.5	-0.2	-0.1	-0.3	-1.9	-0.4	-0.4
Primary Biliary Cirrhosis	0.2	0.3	0.9	0.5	0.8	0.3	0.9	-0.2	0.1
Rheumatoid Arthritis	0.6	0.8	2.9	1.2	-0.5	-0.5	0.1	1.7	0.2
Schizophrenia (2014)	0.5	1.0	2.2	-0.9	-0.1	-0.4	-0.9	1.4	1.5
Triglycerides	0.8	1.3	3.8	-0.3	0.6	0.4	1.5	2.0	1.1
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.6	0.5	-1.3	-0.8	-1.2	-0.4	-1.9
Ulcerative Colitis	2.2	3.2	8.1	-1.6	-1.6	-2.4	0.4	2.9	-0.2
Blood Eosinophil Count	0.1	1.0	2.8	-0.7	0.0	0.1	-1.5	-1.7	-0.5
Blood Platelet Count	0.0	0.5	1.0	-0.8	0.7	0.7	-0.3	-0.0	-1.0
Blood Red Count	0.3	2.7	5.6	-2.4	-1.0	-0.8	1.3	2.3	1.5
Blood White Count	0.5	3.8	6.5	1.4	2.2	2.5	-1.4	-2.5	-1.1
Heel T-Score	0.1	0.7	1.3	1.1	0.7	1.1	0.3	-0.7	-0.7
BMI	0.1	0.4	0.9	0.5	0.2	0.6	-1.0	0.6	-0.9
Height	0.1	2.3	10.2	-0.7	-1.4	-3.2	-0.7	0.6	-0.5
Waist Hip Ratio (WHR)	0.2	0.8	2.4	0.8	0.3	1.5	0.8	-0.6	-0.7
Systolic Blood Pressure	1.6	7.8	35.7	-6.0	-1.9	-1.9	0.5	1.6	1.1
Smoking Status	0.5	1.3	2.8	1.7	1.2	1.4	-0.2	0.9	1.0
Allergy or Eczema	0.5	1.4	7.8	0.1	0.5	0.1	0.0	-2.8	-0.7
Cardiovascular Disease	0.2	0.7	1.4	-0.7	0.6	0.9	-1.2	-0.7	-0.7
Hypothyroidism (self reported)	0.2	0.4	1.3	-0.4	0.8	0.1	-0.4	1.1	0.1
Respiratory disease	0.2	0.5	1.3	-1.0	-0.5	-0.4	0.1	-0.5	-1.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.7	1.1	0.9	1.3	-0.7	-0.9	-0.5
Lung FEV1/FVC ratio	0.1	0.4	0.9	0.8	0.5	1.0	0.1	0.1	0.5
Lung FVC	0.1	0.3	1.5	1.2	0.1	-0.2	-0.3	0.4	-0.0
Neuroticism	0.9	2.2	4.8	-0.2	1.9	1.4	-2.2	-1.5	0.7
Chronotype (morning person)	0.6	1.4	2.5	0.8	-1.1	-1.6	-1.6	0.6	-1.1
Hair Pigment	0.0	0.4	1.9	-0.3	-0.0	-1.4	0.0	-0.3	0.3
Tanning	0.1	1.1	3.6	0.5	1.5	1.9	0.3	-0.5	0.4
Hand grip strength (left)	0.5	1.4	4.7	2.2	-0.7	0.0	-0.7	-0.5	-1.6
Number of treatments/medications taken	0.6	1.1	5.4	-2.3	0.0	-0.5	-0.2	-0.8	-0.3
Average weekly spirits intake	1.8	2.3	7.0	-0.2	0.0	0.5	1.3	2.6	2.2
Sensitivity / hurt feelings	0.3	0.5	1.2	0.5	1.1	0.5	0.2	0.4	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.0	-0.7	0.8	1.0	-0.4	-0.0	-0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.9	-0.4	-0.0	-0.8	0.9	1.4	0.4
Relative age of first facial hair	0.4	0.9	2.7	0.9	-1.2	-0.3	-1.6	-0.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.3	-0.1	1.3	1.8	1.1	0.6	0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	4.6	0.5	-0.8	-0.5	-0.1	2.1	-0.1
Ever had hysterectomy (womb removed)	2.1	2.4	5.7	1.7	2.4	1.8	-1.4	-0.5	0.5
Systolic blood pressure, automated reading	0.6	1.9	10.2	-3.2	-0.4	-0.4	-0.5	0.6	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.9	0.1	0.3	0.9	-0.7	-0.1
Angina	0.5	0.6	2.8	-1.7	0.5	0.0	0.1	0.6	-0.5
Medication for hormone replacement therapy	1.2	1.4	3.4	0.9	-0.3	0.5	1.3	1.8	1.4
Vitamin and mineral supplements	0.7	1.0	3.6	0.9	0.1	0.9	0.5	-1.9	-0.6
Supplements: Zinc	1.2	1.3	5.3	0.5	-0.0	0.5	2.3	1.0	1.1
Medication: Co-codamol	3.8	4.5	6.2	-2.1	-0.9	-2.5	2.1	2.2	2.5
Medication: Metformin	0.3	0.4	1.0	0.3	-0.3	1.0	-1.0	0.4	0.6
Diabetes (father)	1.2	1.5	3.2	1.8	1.1	1.5	0.4	0.2	1.4
Diabetes (mother)	1.9	2.5	6.3	-0.4	-2.1	-1.1	1.6	2.5	0.7
Severe depression (siblings)	0.9	1.0	1.6	-0.8	-1.3	-1.3	0.9	1.0	0.4
Pack years adult smoking proportion	0.3	0.5	1.1	0.1	0.6	0.6	-0.9	-1.1	-0.7
Impedance of leg (right)	0.2	0.7	1.1	1.0	-0.7	1.1	0.9	-0.9	-0.4
Leg fat-free mass (left)	0.2	0.8	1.7	-0.8	0.1	-1.3	-1.1	1.2	0.4
Trunk fat percentage	0.2	0.7	2.4	0.2	-0.2	1.2	-0.2	1.5	0.5
Hand grip strength (right)	0.2	0.6	2.1	1.5	-0.1	0.9	0.6	0.3	0.2
Townsend deprivation index at recruitment	0.9	1.2	3.0	-0.6	-0.0	1.5	1.3	1.7	0.5
Current tobacco smoking	1.3	2.1	3.3	1.0	1.8	1.8	-0.2	1.5	1.7
Average weekly fortified wine intake	1.1	1.3	3.8	1.1	-0.1	0.2	-2.0	-0.8	-1.5
Maternal smoking around birth	0.9	1.3	3.6	0.5	1.9	1.8	-0.4	0.1	0.5
Fed-up feelings	0.4	0.7	2.6	-1.6	-0.4	-0.9	-0.7	0.2	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.2	-1.5	1.1	1.2	0.3	0.7	0.3
Relative age voice broke	0.7	1.1	2.1	1.4	-0.8	-0.2	0.5	1.5	1.2
Taking other prescription medications	0.6	0.9	2.8	-0.0	-0.9	-0.4	-1.0	-0.7	-1.7
Age when periods started (menarche)	0.4	0.8	3.0	0.9	-0.6	-0.3	-1.7	0.4	-0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	-0.1	1.4	1.0	-0.5	-1.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	-0.4	-0.0	0.2	-1.3	-0.8	-0.5
Tinnitus: Yes, but not now, but have in the past	2.7	2.8	6.6	0.7	1.4	1.7	1.4	1.7	2.6
Qualifications: CSEs or equivalent	1.3	1.7	4.3	2.1	-1.2	-0.8	0.2	-1.0	-1.7
Serious illness, injury or assault to yourself	0.5	0.6	1.6	-1.3	-0.3	-0.0	1.2	0.3	0.5
High blood pressure	0.8	2.1	10.8	-3.3	0.8	0.6	0.9	-0.1	0.3
Hayfever, allergic rhinitis or eczema	0.6	1.4	6.9	0.5	0.4	0.3	-0.4	-2.6	-0.8
Multivitamins +/- minerals	0.9	1.2	2.6	-1.3	0.4	-0.8	-0.0	1.6	1.3
Stomach or abdominal pain in last month	0.4	0.5	2.2	0.1	-0.8	0.0	1.5	-0.2	0.1
Supplements: Glucosamine	0.2	0.3	0.6	0.0	0.7	0.7	-0.3	0.7	-0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.8	-0.9	0.1	0.6	-0.3	-0.4	0.1
Medication: Atenolol	2.2	2.7	9.5	-3.1	-0.8	-1.9	-1.0	-0.4	-1.2
Medication: Levothyroxine sodium	0.7	1.2	2.9	-1.2	-1.2	-1.0	0.8	1.7	-0.0
Sitting height	0.7	5.1	14.0	-3.0	-2.1	-3.7	-0.0	0.9	1.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.9	0.3	0.7	0.9	0.2	0.2	0.4
High blood pressure (mother)	0.1	0.2	0.7	-0.3	0.1	-0.1	0.3	-0.4	0.8
Body mass index (BMI)	0.1	0.6	1.5	0.3	0.6	0.7	-1.2	1.2	0.1
Impedance of leg (left)	0.1	0.7	2.2	0.5	-0.5	0.9	1.5	-0.8	0.2
Leg predicted mass (left)	0.2	0.9	1.7	-0.8	0.0	-1.3	-1.1	1.3	0.3
Trunk fat mass	0.2	0.7	3.1	-0.2	-0.2	0.6	-0.5	1.8	0.4
Waist circumference	0.2	0.6	1.4	-0.3	0.7	0.8	-1.0	1.2	-0.0
Number of incorrect matches in round	0.6	1.0	2.3	0.5	1.2	1.5	1.5	0.1	0.1
Past tobacco smoking	0.3	0.5	1.3	-0.4	1.2	-0.4	0.5	-0.7	0.6
Alcohol usually taken with meals	0.9	1.4	2.6	-1.6	-0.5	-0.6	1.3	-1.4	1.3
Nervous feelings	0.5	1.0	2.1	0.1	-1.2	-1.1	-1.4	-0.1	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.6	-0.9	-0.5	0.4	0.6	1.3	-0.1
Hearing difficulty/problems with background noise	0.1	0.2	0.5	-0.7	0.2	-0.1	-0.7	0.3	-0.5
Hair/balding pattern: Pattern 2	0.6	0.8	2.3	1.3	0.5	1.5	0.4	-0.3	0.4
Had menopause	0.3	0.4	1.7	-0.0	0.5	0.5	0.0	0.1	1.3
Had other major operations	0.2	0.3	0.9	-0.7	-0.5	0.3	-0.1	-0.1	0.9
Forced vital capacity (FVC)	0.3	1.1	2.1	0.1	-1.4	-1.4	-1.4	-0.0	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.8	-0.1	-0.1	-0.3	-2.0	-1.3	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.2	0.3	0.2	1.1	1.0	0.9	0.6
Qualifications: None of the above	1.0	2.2	7.7	0.9	2.8	1.3	-0.7	1.2	1.1
Financial difficulties in last 2 years	1.0	1.4	3.3	-0.8	1.8	0.5	1.2	0.4	1.6
Mouth/teeth dental problems	0.4	0.6	2.2	1.1	-0.1	-0.2	0.1	-1.5	-0.2
Heart attack	1.3	1.6	5.1	-1.2	-1.0	-2.3	-0.3	1.3	-0.7
Allergy	0.5	1.1	5.5	0.1	0.1	-0.3	0.3	2.4	0.8
Pain all over the body in last month	1.4	1.6	3.3	0.4	-0.2	-0.3	-1.5	-1.8	-1.8
Diabetes (self-reported)	0.4	0.7	1.8	0.3	0.8	1.3	-0.1	-0.9	0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.8	0.4	1.7	0.4	0.6	0.2	0.5
Medication: Ramipril	1.0	1.3	4.5	-2.1	-1.2	-0.2	-0.3	-1.0	-0.8
Medication: Simvastatin	0.3	0.5	1.2	-0.8	0.6	0.4	1.1	-0.8	-0.2
Fluid intelligence score	0.1	0.1	0.3	-0.3	-0.2	-0.5	-0.1	-0.3	-0.5
Illnesses of siblings	2.1	2.9	5.4	2.3	-0.7	-1.2	-2.0	-1.8	-1.7
Neuroticism score	0.3	0.6	1.5	-0.2	0.9	1.2	-0.6	-0.1	1.1
Weight	0.2	0.8	2.2	-0.5	0.0	-0.6	-1.3	1.5	0.3
Impedance of arm (right)	0.2	0.8	2.7	-0.6	-1.6	0.4	1.3	-0.1	0.1
Arm fat percentage (right)	0.2	0.8	3.5	-0.4	-0.4	0.8	-0.4	1.9	0.6
Trunk fat-free mass	0.3	1.8	5.0	-0.8	0.1	-2.1	-2.2	0.9	0.1
Hip circumference	0.3	1.2	3.5	-1.0	0.2	-0.4	-1.1	1.9	1.0
Time employed in main current job	1.1	1.2	3.1	-1.2	-1.3	-0.6	-1.8	0.9	0.2
Alcohol intake versus 10 years previously	0.4	0.7	1.4	1.2	1.0	0.6	0.4	0.3	-1.0
Father’s age at death	0.3	0.4	0.9	0.6	-0.9	-1.0	0.1	0.6	0.1
Worrier / anxious feelings	0.2	0.5	1.1	0.5	0.8	1.0	0.4	0.8	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	5.2	-0.1	1.8	2.3	1.4	-0.2	0.2
Falls in the last year	0.3	0.3	1.0	0.8	-1.0	0.1	0.2	0.6	0.2
Hair/balding pattern: Pattern 3	0.8	1.2	2.1	-1.2	-1.5	-1.5	-0.1	1.2	0.2
Number of live births	0.7	0.9	2.4	-0.7	-0.8	-0.9	0.6	1.5	1.0
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.4	-0.1	-1.4	-1.6	-1.0	0.6	-0.7
Pulse rate	0.1	0.2	0.7	0.3	0.3	-0.3	-0.9	0.5	0.3
Happiness	0.5	0.7	1.4	-1.2	0.2	1.0	0.6	0.4	1.0
Noisy workplace	0.4	0.4	1.3	0.6	1.2	0.8	0.3	0.4	0.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.1	-1.2	-1.0	-0.2	1.4	0.6	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	1.2	0.8	0.5	-0.9	0.1	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.6	1.1	0.1	-0.8	-0.0	-0.8	1.0	-1.1
Asthma	0.3	0.5	1.3	-0.6	-0.8	-0.3	-0.5	-0.7	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.0	-0.7	0.8	-0.9	1.0	1.4	1.0
Medication: Cholesterol lowering	0.6	0.9	3.2	-0.7	0.3	-0.3	0.0	-1.2	-1.8
Depression (self-reported)	0.2	0.2	0.5	-0.4	0.4	-0.1	0.4	-0.5	0.7
Medication: Lansoprazole	1.6	1.8	4.4	-0.6	1.3	1.7	1.2	-0.5	2.1
Prospective memory result	0.5	0.7	1.8	-0.7	-0.9	-1.3	0.4	0.4	-0.6
Lung cancer (father)	1.2	1.4	3.8	2.0	-1.1	-0.6	-1.6	0.3	0.1
Illnesses of mother	0.5	0.6	2.1	0.1	0.6	0.5	-0.7	-1.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.1	0.2	-0.9	-1.0	-0.8	0.7	-0.5
Pulse wave Arterial Stiffness index	1.2	1.4	3.5	-0.9	-0.2	-1.9	-0.5	1.5	1.3
Impedance of arm (left)	0.2	0.9	2.9	-0.1	-1.7	0.0	1.5	-0.7	-0.2
Arm fat mass (right)	0.2	0.8	3.3	-0.8	-0.3	0.1	-0.9	1.8	0.6
Trunk predicted mass	0.3	1.9	5.2	-0.9	-0.0	-2.3	-2.1	1.0	0.2
Standing height	0.2	2.1	7.6	-1.6	-1.1	-2.8	-0.8	0.5	0.5
Length of working week for main job	0.3	0.4	1.4	1.2	-0.1	-0.1	-0.5	-0.2	-0.7
Exposure to tobacco smoke at home	2.3	2.5	5.5	-0.9	-2.1	-2.3	-0.4	1.9	-1.0
Breastfed as a baby	0.5	0.7	1.9	1.0	0.6	0.5	-1.4	-0.6	-0.0
Tense / ‘highly strung’	0.6	1.1	1.8	1.1	1.2	1.2	-1.3	0.8	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.4	-0.7	-0.9	-0.4	1.6	1.1	1.0
Hair/balding pattern: Pattern 4	0.4	1.1	3.7	-0.3	1.9	0.5	-0.0	-0.7	1.4
Birth weight of first child	0.4	0.7	2.6	0.6	0.3	-0.1	1.6	0.1	0.9
Peak expiratory flow (PEF)	0.7	1.6	5.0	0.8	-1.1	-1.1	-2.2	0.1	-1.4
Pulse wave reflection index	1.0	1.2	2.2	-0.6	-1.5	-1.5	-0.5	1.5	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	-0.4	0.5	0.1	-0.7	0.7	-0.1
Loud music exposure frequency	1.3	1.4	3.5	-1.1	-1.9	-1.3	-0.7	1.0	-0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.4	3.0	-0.7	-1.7	-0.4	1.4	1.6	0.6
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.0	-2.0	-1.3	-0.5	-0.5	1.4	0.1
Blood clot in the leg (DVT)	0.8	1.0	2.6	0.9	1.6	0.7	-0.7	-1.3	-0.6
Medication: Paracetamol	0.3	0.5	1.0	-0.2	0.9	1.0	-0.5	-0.8	0.3
Headache pain in last month	0.5	0.9	1.7	-1.3	0.1	0.5	1.3	-0.3	1.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.7	1.3	-0.1	-0.3	-0.4	1.2	1.3
Glaucoma (self-reported)	0.6	0.7	3.5	0.1	-1.9	-0.2	-0.3	0.4	-0.5
Gout (self-reported)	0.8	1.1	3.8	-0.5	2.0	1.4	-0.1	-0.3	0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.7	-0.4	0.7	0.2	0.3	0.9	0.5
Medication: Amlodipine	1.2	1.7	3.4	0.7	0.8	0.4	-1.7	-1.7	-1.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.1	-0.1	-0.0	0.7	-1.4	-1.2	-1.2
Birth weight	0.3	0.6	2.7	-0.0	-1.7	-0.9	-0.1	0.3	-0.2
Chronic bronchitis/emphysema (mother)	0.8	1.0	3.3	0.9	1.8	1.1	0.8	-0.1	-0.2
High blood pressure (siblings)	2.0	2.9	8.5	-2.9	0.2	1.5	1.7	0.4	1.8
Forced vital capacity (FVC), Best measure	0.2	0.6	1.4	-0.0	-1.2	-1.0	-1.0	0.5	-0.4
Body fat percentage	0.2	0.8	2.6	0.2	-0.0	1.4	-0.0	1.6	0.4
Leg fat percentage (right)	0.3	0.9	2.7	0.2	-0.0	1.6	-0.2	1.6	0.4
Arm fat-free mass (right)	0.2	1.0	2.8	-0.3	0.6	-1.5	-1.7	0.8	0.2
Exposure to tobacco smoke outside home	1.0	1.3	3.7	-1.9	-0.6	-0.6	0.7	1.5	0.8
Comparative body size at age 10	0.4	1.0	2.6	1.6	0.2	0.9	0.6	1.4	-0.5
Number of full brothers	0.7	0.9	2.0	1.4	0.3	1.2	0.9	-1.0	0.2
Worry too long after embarrassment	0.4	0.6	2.4	-1.6	0.1	0.2	-0.2	-1.0	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.5	-0.7	-1.1	-1.1	1.4	1.4	1.6
Wheeze or whistling in the chest in last year	0.7	1.3	4.3	1.3	1.0	2.1	0.0	-0.0	-0.9
Number of children fathered	0.1	0.1	0.1	0.2	0.2	-0.4	-0.3	-0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	3.7	-1.9	0.5	-0.0	0.5	0.7	1.2
Age at first live birth	0.3	0.5	1.7	0.4	-1.1	-0.0	0.5	-0.1	-1.3
Pulse wave peak to peak time	1.1	1.3	2.8	0.9	-0.0	1.7	0.4	-1.4	-1.4
Health satisfaction	1.9	2.4	9.3	-0.4	1.4	3.0	1.2	0.8	1.0
Shortness of breath walking on level ground	0.1	0.2	0.6	0.1	0.0	0.3	-0.4	0.8	0.4
Qualifications: College or University degree	0.2	0.6	1.8	-0.3	-0.5	0.3	0.5	-1.0	-1.3
Eye problems/disorders: None of the above	1.0	1.2	3.9	0.4	1.3	-0.7	-2.0	-0.9	0.2
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.7	-0.4	-0.7	-1.9	-1.4	1.3	0.0
Emphysema/chronic bronchitis	0.5	0.6	1.3	-0.3	-0.3	1.1	-1.0	0.1	-1.1
Medication for pain relief, constipation, heartburn	0.2	0.3	0.5	0.7	-0.2	0.6	0.6	-0.4	0.3
Neck or shoulder pain in last month	0.3	0.5	1.4	-1.2	0.5	0.6	0.4	0.7	0.3
Medication: Blood pressure	0.5	0.9	2.2	-1.5	-0.1	0.8	0.6	-1.2	-0.9
Angina (self-reported)	0.5	0.6	2.9	-1.7	0.6	-0.0	0.0	0.6	-0.2
Migraine (self-reported)	2.9	3.6	9.2	-3.0	-2.1	-2.0	1.4	0.1	1.5
Medication: Ibuprofen	1.2	1.4	3.5	-0.2	0.9	-0.7	1.9	1.2	1.5
Medication: Allopurinol	1.4	1.9	3.9	0.8	1.9	2.0	-0.7	-1.5	-0.6
Medication: Omeprazole	0.7	0.8	2.3	0.1	-0.7	-0.3	-1.3	-1.5	-0.6
Medication: Seretide 50 evohaler	0.2	0.3	0.9	-1.0	0.2	-0.1	0.5	0.2	-0.6
Mean time to correctly identify matches	1.4	2.7	6.0	-0.3	-1.4	-1.0	-2.1	-2.4	-1.7
Heart disease (mother)	1.6	1.9	7.4	-1.6	-0.9	0.0	0.8	2.7	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.7	3.2	5.6	0.9	-2.4	-1.8	-0.3	-2.0	-2.2
Whole body fat mass	0.1	0.6	2.3	-0.1	0.0	0.7	-0.6	1.5	0.4
Leg fat mass (right)	0.1	0.5	1.9	0.1	-0.0	1.1	-0.4	1.4	0.3
Arm predicted mass (right)	0.2	1.0	2.7	-0.3	0.4	-1.5	-1.6	1.0	0.2
Pulse rate, automated reading	0.1	0.3	1.1	0.7	-0.1	-0.2	-1.1	0.4	-0.1
Alcohol intake frequency.	0.5	1.2	2.3	-1.5	-0.2	-0.7	1.5	1.4	0.4
Comparative height size at age 10	0.1	0.7	2.5	-1.2	-0.1	-1.6	0.1	-0.5	-0.2
Number of full sisters	0.5	0.7	2.1	-1.4	0.2	-0.6	-1.0	-0.1	0.7
Suffer from ‘nerves’	1.4	2.3	4.4	-1.0	-1.4	-1.9	-2.1	-1.1	-1.3
Overall health rating	0.6	1.2	5.0	-0.4	0.5	1.2	2.2	0.5	-0.0
Chest pain or discomfort	2.5	3.6	9.5	-1.5	-0.9	0.2	2.5	3.1	1.6
Had major operations	3.7	4.3	10.3	-1.5	-2.6	-1.1	0.7	3.2	2.3
Age at last live birth	0.5	0.7	2.1	0.3	-1.4	-0.1	0.4	-0.2	-1.3
Family relationship satisfaction	1.5	1.8	5.9	-0.8	0.5	1.7	2.4	1.0	0.4
Leg pain on walking	1.0	1.2	3.6	-0.6	-0.2	0.3	0.9	1.9	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.0	1.4	1.0	0.4	0.5	-0.5	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.8	0.2	-0.4	0.2	0.5	-0.9	-0.1
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.8	1.1	0.8	1.2	-0.9	-0.6	-1.7
Medication: Aspirin	1.2	1.6	3.1	-1.4	-1.0	-1.7	-1.8	0.5	-0.8
Supplements: Vitamin C	0.9	1.1	5.3	-0.5	0.2	-0.2	0.9	2.3	0.0
Knee pain experienced in last month	0.7	1.1	3.1	-0.2	1.4	0.6	0.9	0.8	1.8
Hypertension (Self-reported)	0.6	1.8	8.7	-2.9	0.7	0.5	1.1	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.8	1.7	0.2	1.2	-0.8	-0.6	-0.8
Illnesses of father: Heart disease	1.0	1.4	4.9	-2.2	-1.0	-1.2	0.8	0.5	0.2
Illnesses of siblings: Diabetes	1.2	1.4	4.3	-0.6	-1.5	-0.7	0.4	2.1	1.0
Smoking status: Previous	0.4	0.6	2.5	0.0	-1.6	-0.0	-0.1	0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	4.1	1.7	0.4	-0.1	-1.9	-0.7	-2.0
Whole body fat-free mass	0.2	1.4	3.7	-0.8	0.1	-1.9	-1.7	1.0	0.2
Leg fat-free mass (right)	0.2	1.0	2.2	-1.1	0.2	-1.5	-0.7	1.3	0.7
Arm fat percentage (left)	0.2	0.7	2.8	-0.2	-0.3	0.8	-0.3	1.7	0.5
Average weekly red wine intake	1.5	2.2	6.2	-2.5	-1.7	-1.4	0.3	-0.3	1.4
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.0	-1.0	0.6	-0.3	-0.5	-0.1	0.7
Mood swings	0.1	0.2	0.4	-0.4	-0.3	0.3	-0.6	0.6	0.7
Loneliness, isolation	2.0	2.8	4.2	-1.8	-1.4	-0.7	1.7	2.0	1.9
Long-standing illness, disability or infirmity	1.6	2.5	9.8	-1.2	1.1	0.8	3.1	0.6	1.2
Ever had bowel cancer screening	0.2	0.2	0.7	0.2	0.2	0.9	0.6	-0.1	-0.1
Diabetes diagnosed by doctor	0.6	0.9	2.6	0.5	1.1	1.6	0.0	-0.8	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	1.0	0.5	1.0	0.7	-0.1	0.9	0.2
Friendships satisfaction	1.8	2.2	7.6	-2.8	0.3	-0.2	1.9	0.7	1.1
Qualifications: nursing, teaching	0.2	0.3	0.8	-0.5	-0.9	-0.2	0.4	0.4	0.3
Commuting to job workplace: Walk	0.5	0.5	1.4	1.2	0.7	-0.9	0.6	0.4	0.0
Eye problems/disorders: Cataract	1.7	2.0	6.8	-1.8	0.5	1.3	2.6	-0.1	0.6
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.4	1.9	1.4	1.5	0.0	-0.1	-0.4
Medication for cholesterol	0.3	0.4	1.2	1.1	0.3	0.4	-0.6	-0.2	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.0	0.3	-0.3	-0.5	0.6	1.0	0.1
Back pain experienced in last month	0.3	0.4	1.0	1.0	0.7	0.6	-0.5	0.1	-0.7
Mineral and other dietary supplements	0.3	0.4	1.9	0.5	-0.3	0.1	0.2	-1.4	0.3
Breast cancer (self-reported)	0.2	0.2	0.8	0.9	0.3	0.3	0.2	-0.1	-0.2
Asthma (self-reported)	0.5	0.9	2.5	-0.4	-0.8	-0.3	-1.2	-0.9	-1.6
Osteoporosis (self-reported)	0.8	1.0	2.6	0.7	0.7	1.2	1.6	-0.1	1.0
Osteoarthritis (self-reported)	0.4	0.5	1.6	-1.0	0.3	0.3	-0.2	1.3	-0.4
Medication: Aspirin	1.6	2.0	3.6	-1.7	-1.4	-1.7	-1.9	0.4	-1.0
Medication: Gliclazide	0.9	1.0	2.1	1.2	1.2	1.5	-0.0	0.1	1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	1.2	0.8	0.9	-0.0	-0.1	0.6
Smoking status: Current	1.0	1.5	2.5	1.1	1.6	1.6	-0.3	1.1	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.8	0.4	0.8	0.0	-0.1	1.3	-0.4
Whole body water mass	0.3	1.5	3.9	-0.8	0.1	-2.0	-1.8	1.1	0.2
Leg predicted mass (right)	0.2	1.0	2.3	-1.1	0.2	-1.5	-0.7	1.3	0.7
Arm fat mass (left)	0.2	0.7	2.9	-0.4	-0.2	0.1	-0.8	1.7	0.5
Number of self-reported non-cancer illnesses	0.5	0.9	3.9	-2.0	0.3	0.1	0.3	-0.6	-0.9
Average weekly champagne plus white wine intake	0.3	0.4	1.3	0.1	0.2	0.8	-0.5	-1.2	0.5
Miserableness	0.5	0.8	4.0	-2.0	-0.8	-0.6	-0.0	0.2	-0.3
Guilty feelings	0.8	1.2	2.7	0.5	1.6	0.9	-0.4	-1.7	0.5
Wears glasses or contact lenses	1.2	1.4	3.9	2.0	0.6	1.6	-0.3	-0.8	-0.8
Ever taken oral contraceptive pill	0.8	0.9	3.4	-0.6	0.4	1.0	0.7	-1.9	-0.1
Hearing aid user	0.9	1.0	1.8	-0.7	1.3	-0.1	1.0	1.3	0.9
Mother’s age at death	0.6	0.7	2.4	0.2	-0.4	-0.8	1.6	0.5	1.0
Financial situation satisfaction	2.0	2.4	4.7	-1.8	0.6	-0.5	1.3	2.1	2.2
Tinnitus: Yes, now most or all of the time	0.8	1.0	3.2	-0.8	-0.2	-1.8	-0.7	0.1	-1.2
Commuting to job workplace: Public transport	1.0	1.2	3.7	-0.5	-0.5	-1.0	-0.1	1.4	1.9
Eye problems/disorders: Glaucoma	0.6	0.8	1.9	-0.5	-1.4	-0.1	1.2	0.8	0.7
Medication: Blood pressure	0.4	0.7	3.5	-1.9	0.5	0.1	0.1	-0.4	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.7	-0.3	0.5	-0.2	-0.2	-1.3	-1.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.1	0.7	-0.3	-0.7	0.8	-0.7
High cholesterol (Self-reported)	0.6	1.0	2.8	1.7	1.0	0.9	-0.9	-0.7	-0.4
Medication: Bendroflumethiazide	1.0	1.5	3.8	-1.2	-0.3	-0.3	-2.0	-1.4	-1.2
Medication: Paracetamol	1.3	2.1	4.3	1.0	2.1	2.0	-0.5	-1.6	0.3
Medication: Lisinopril	0.9	1.2	4.9	-2.2	0.0	-0.5	0.9	0.0	1.1
Medication: Atorvastatin	0.8	0.9	2.6	0.9	-1.0	-0.6	-0.3	-0.8	-1.6
Illnesses of father: High blood pressure	0.9	1.1	4.7	-2.2	0.8	-0.9	-0.2	-0.1	0.6
Alcohol drinker status: Never	0.7	0.8	2.7	0.7	0.6	-0.3	0.7	1.6	0.8
Ever smoked	0.2	0.4	1.0	0.2	-0.6	0.7	-0.7	1.0	0.0
Basal metabolic rate	0.2	1.2	2.8	-0.7	0.0	-1.6	-1.7	1.2	0.2
Leg fat percentage (left)	0.3	0.9	2.8	-0.0	0.2	1.5	0.1	1.7	0.7
Arm fat-free mass (left)	0.3	1.3	2.8	-0.9	0.3	-1.7	-1.4	1.4	0.5
Number of operations (self-reported)	0.4	0.6	1.0	0.6	-1.0	0.8	-0.4	0.8	1.0
Average weekly beer plus cider intake	0.5	0.7	2.9	1.7	-0.4	0.1	-0.7	0.4	-0.6
Irritability	0.6	1.1	3.1	0.3	0.8	1.8	-0.2	1.6	-0.1
Risk taking	0.7	1.1	2.5	1.4	1.0	0.8	-1.6	-0.4	-0.6
Ever had prostate specific antigen (PSA) test	1.5	1.8	3.2	-0.5	-1.8	-1.8	-1.4	-0.4	-1.4
Fractured/broken bones in last 5 years	0.7	0.9	2.2	0.6	1.4	1.5	0.8	-0.3	0.8
Age started oral contraceptive pill	1.0	1.2	4.1	-0.4	-1.5	-2.0	-0.2	1.0	-0.3
Diastolic blood pressure, automated reading	0.7	2.1	8.1	-2.9	-0.5	-0.9	-0.7	1.6	0.4
Ever depressed for a whole week	0.6	0.8	2.6	-0.1	0.5	0.3	0.8	1.6	1.1
Unable to work because of sickness or disability	0.8	1.0	3.1	-1.2	0.8	0.2	1.8	-0.4	0.9
Commuting to job workplace: Cycle	0.1	0.2	0.4	0.4	0.5	0.6	-0.0	0.4	0.0
Myopia	1.6	2.3	7.2	1.1	-1.7	-0.9	-0.3	-1.2	-2.7
Vascular/heart problems diagnosed by doctor	0.9	2.4	13.0	3.6	-0.9	-0.2	-0.6	-0.1	-0.0
Cholesterol lowering medication	0.1	0.1	0.3	0.3	-0.6	-0.5	-0.3	0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.1	-0.0	-0.5	-0.4	-1.7	-2.3	-1.0
Pain experienced in last month	0.2	0.3	0.8	0.4	-0.6	0.6	-0.3	-0.9	-0.3
Supplements: Calcium	0.4	0.5	1.1	0.1	0.6	0.9	1.1	0.4	0.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.8	1.7	-0.2	-0.9	-1.3	-0.9	-1.1
Heart attack/myocardial infarction (self-reported)	1.3	1.7	5.6	-1.2	-0.9	-2.4	-0.3	1.4	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.7	0.9	1.3	0.5	-0.6	-1.2	-0.7
Heart disease (siblings)	0.4	0.4	1.0	-0.6	-0.2	1.0	0.3	0.7	0.7
Alcohol drinker status: Previous	1.3	1.5	5.7	-2.4	1.4	0.4	-0.5	-0.8	0.5
Pack years of smoking	0.2	0.3	0.7	-0.0	0.5	0.7	-0.6	-0.9	-0.5
Impedance of whole body	0.2	0.9	2.3	0.3	-1.3	0.5	1.5	-0.9	-0.1
Leg fat mass (left)	0.2	0.6	2.0	-0.1	0.2	1.1	-0.3	1.4	0.6
Arm predicted mass (left)	0.3	1.4	3.2	-0.9	0.2	-1.8	-1.6	1.2	0.5