Hub : Genes

MZF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1830	0.0600	5.3e-05	0.122	NA	0.077	NA	0.085	2.1e-06	NA	1.5e-04	NA	7.2e-05
2	GTEx	Testis	0.3330	0.0950	6.9e-06	0.044	NA	0.154	NA	0.132	4.7e-03	NA	2.5e-07	NA	1.8e-06
3	YFS	Blood	0.0900	0.0205	0.0e+00	0.076	0.079	0.076	0.08	0.081	1.4e-23	1.3e-24	7.9e-24	9.7e-25	4.2e-25
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0719	0.0346	6.0e-05	0.038	0.036	0.035	NA	0.042	3.5e-05	5.4e-05	7.2e-05	NA	1.5e-05
5	TCGA	Pancreatic Adenocarcinoma	0.1830	0.1560	2.4e-03	0.015	0.015	0.000	NA	0.009	7.5e-02	7.2e-02	3.3e-01	NA	1.2e-01
6	TCGA	Prostate Adenocarcinoma	0.0469	0.0271	5.3e-03	0.005	0.014	0.018	NA	0.004	8.3e-02	1.0e-02	4.9e-03	NA	1.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	5.5	8.6	16.9	3.8	2.2	-3.2	4.1	0.7	2.3
Bipolar Disorder or Schizophrenia	4.6	11.2	24.3	3.3	3.1	-4.9	4.5	1.3	1.1
Depressed Affect (Nagel 2018)	0.2	0.3	0.5	0.2	-0.7	-0.4	-0.6	0.6	-0.7
Depression (Nagel 2018)	0.3	0.5	1.0	0.6	-0.7	-0.9	1.0	0.1	0.2
Intelligence (Savage-Jansen 2018)	4.2	13.0	24.0	4.9	1.4	-2.7	4.7	1.6	4.5
Neuroticism (Nagel 2018)	0.4	1.0	4.9	2.2	-0.1	-0.5	0.2	0.6	0.5
Schizophrenia (2018)	2.2	4.6	14.0	1.2	2.3	-3.7	2.4	1.1	-0.5
Schizophrenia vs Biploar Disorder	0.4	0.6	2.1	-1.4	-0.6	-0.8	0.2	0.6	-0.4
Worry (Nagel 2018)	0.5	1.1	5.5	2.3	0.2	-0.1	0.4	0.4	0.9
Alzheimer’s Disease (in mother)	0.1	0.1	0.4	-0.5	-0.1	-0.1	-0.0	0.6	0.5
Alzheimer’s Disease (in father)	0.5	0.6	1.1	0.4	0.1	-0.7	1.0	0.7	1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.8	-0.2	-0.5	-0.7	0.6	0.9	0.8
Crohns Disease (2017)	0.9	1.9	3.4	-0.4	1.1	-1.8	1.8	1.4	1.1
Irritable Bowel Disease (IBD)	1.1	2.7	5.7	-0.9	2.4	-2.1	1.7	1.5	0.6
Ulcerative Colitis (UC)	1.0	1.9	4.8	-0.9	2.2	-1.5	1.1	1.4	0.3
Major Depression (MDD)	4.8	5.8	8.4	1.3	2.9	-2.1	2.5	2.5	2.8
Reaction Time	0.8	1.5	5.7	-2.4	-0.7	0.3	-1.2	1.0	-0.6
Verbal and Numeric Reasoning (VNR)	2.7	6.4	16.9	4.1	1.3	-1.0	2.9	0.5	3.2
Breast Cancer	1.0	2.3	4.0	2.0	0.6	-1.3	1.9	1.0	1.8
Ovarian Cancer	0.4	0.5	2.0	1.4	-0.2	-0.1	0.6	0.1	0.9
Prostate Cancer	0.3	0.4	1.1	1.1	0.3	-0.6	0.7	-0.1	0.4
Age at First Birth	0.9	1.3	4.3	-2.1	-0.7	-0.9	0.3	1.3	0.5
Bipolar Disorder (2011)	1.8	1.8	5.6	2.4	1.2	-1.9	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.2	3.9	1.1	0.7	2.0	-1.2	0.0	0.0
Coronary Artery Disease (CAD)	0.5	0.6	1.6	-0.8	0.7	-1.3	1.0	0.3	0.1
Crohns Disease (2012)	0.6	1.0	3.6	0.1	1.9	-1.1	0.9	0.5	0.2
Mean Putamen Volume	0.8	1.0	2.2	-1.5	-0.5	0.7	-1.3	-0.1	-1.0
Fasting Glucose	0.8	1.0	2.7	-0.4	-0.2	1.6	-1.2	-1.1	-0.5
HbA1C	0.5	0.5	2.0	0.2	0.3	1.4	-0.5	-0.9	-0.1
HDL Cholesterol	0.2	0.4	1.9	-1.4	-0.5	-0.3	0.0	0.0	0.0
LDL Cholesterol	0.1	0.2	0.7	-0.2	-0.5	0.8	0.0	0.0	0.0
Lupus	1.6	2.4	4.7	-1.4	-1.6	0.8	-1.9	-1.0	-2.2
Neuroticism (2016)	0.2	0.2	0.4	0.6	-0.4	0.7	-0.4	-0.5	-0.1
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.8	-0.8	0.2	0.2	-0.4	0.3
Rheumatoid Arthritis	0.7	1.0	3.2	-0.4	-1.8	0.5	-0.5	-1.0	-1.0
Schizophrenia (2014)	3.1	6.8	18.7	1.9	2.8	-4.3	3.1	1.3	-0.1
Triglycerides	0.0	0.1	0.2	0.3	0.3	0.5	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.0	-1.0	0.4	0.3	0.0	0.0	0.0
Ulcerative Colitis	1.8	2.7	4.7	-2.0	2.2	-1.9	0.4	1.8	-0.5
Blood Eosinophil Count	0.5	4.1	8.0	-1.6	-1.5	2.2	-2.8	-1.5	-2.1
Blood Platelet Count	2.3	26.8	48.3	3.4	-4.5	5.5	-4.9	-7.0	-5.1
Blood Red Count	0.2	2.4	7.6	2.8	0.9	0.8	0.7	-2.2	0.1
Blood White Count	0.3	1.9	5.2	0.9	-0.6	2.3	-1.7	-1.5	-0.5
Heel T-Score	2.5	19.6	27.5	-4.9	-3.3	4.2	-5.2	-3.5	-5.0
BMI	0.1	0.8	2.5	1.6	1.3	-0.2	0.6	-0.4	0.3
Height	0.3	6.3	17.2	-0.1	-2.0	4.2	-2.8	-2.9	-1.1
Waist Hip Ratio (WHR)	0.2	0.9	3.8	-1.9	0.0	-0.1	-0.7	0.8	-0.5
Systolic Blood Pressure	0.2	1.0	5.2	0.8	-2.3	0.3	0.3	-0.1	0.4
Smoking Status	0.5	1.2	2.5	1.0	1.0	-1.1	1.6	0.4	1.2
Allergy or Eczema	0.9	2.2	4.4	-0.4	0.3	-2.1	1.9	1.8	1.4
Cardiovascular Disease	0.4	1.3	4.7	2.2	1.0	-0.6	1.2	-0.2	0.8
Hypothyroidism (self reported)	1.4	3.2	8.4	-2.9	-1.1	1.1	-1.9	-0.9	-2.0
Respiratory disease	1.2	2.7	7.2	-1.1	0.5	-2.7	1.6	2.3	0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	0.0	-0.4	1.1	-0.8	-0.4	-0.1
Lung FEV1/FVC ratio	0.0	0.2	0.6	0.1	0.1	0.0	-0.4	-0.5	-0.7
Lung FVC	0.2	1.3	3.4	-0.9	-1.8	1.1	-0.6	-1.3	-0.5
Neuroticism	0.2	0.5	2.4	1.6	-0.6	-0.1	-0.3	0.4	-0.1
Chronotype (morning person)	1.3	3.0	11.5	-3.4	1.3	-1.4	0.6	1.6	0.3
Hair Pigment	0.4	10.0	16.7	-0.9	-1.5	3.5	-3.9	-3.6	-4.1
Tanning	0.1	1.0	2.6	-1.6	-0.3	-1.0	-0.1	1.5	-0.0
Hand grip strength (left)	2.3	6.0	8.5	-2.0	-1.8	2.5	-2.5	-2.8	-2.9
Number of treatments/medications taken	1.3	2.4	7.3	2.7	1.2	-1.3	1.7	0.2	0.9
Average weekly spirits intake	0.3	0.4	1.1	-0.4	0.0	-0.5	0.0	-0.8	-1.0
Sensitivity / hurt feelings	1.7	3.0	15.9	4.0	0.0	-0.3	0.9	-0.1	1.0
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.6	0.1	-0.5	-1.2	1.3	1.1	1.0
Hearing difficulty/problems: Yes	1.5	2.3	7.1	-1.4	-0.6	0.4	-1.6	-1.4	-2.7
Relative age of first facial hair	2.3	4.8	24.4	4.9	-0.1	0.5	1.0	-1.3	1.2
Other serious medical condition/disability diagnosed by doctor	3.1	4.1	7.0	-2.5	-1.4	1.2	-2.6	-1.0	-2.6
Ever used hormone-replacement therapy (HRT)	2.0	2.6	5.0	0.8	0.6	-1.7	1.6	2.2	2.0
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	0.3	-0.9	0.5	-0.9	-0.1	-0.6
Systolic blood pressure, automated reading	0.3	0.7	3.4	0.6	-1.8	0.4	0.3	-0.2	0.6
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.0	-1.1	-0.4	-0.7	0.7	1.7	1.3
Angina	0.1	0.1	0.7	-0.8	-0.3	0.1	0.1	0.1	0.3
Medication for hormone replacement therapy	3.0	3.3	6.4	1.0	2.5	-1.8	2.3	1.0	1.7
Vitamin and mineral supplements	5.3	7.2	12.2	-3.1	-3.5	2.5	-3.0	-1.2	-2.2
Supplements: Zinc	5.4	5.8	15.4	1.4	3.9	-1.5	2.3	1.6	2.7
Medication: Co-codamol	1.2	1.4	2.6	1.0	-0.1	-1.1	1.6	1.0	1.6
Medication: Metformin	0.2	0.3	0.9	1.0	0.3	0.0	0.2	0.3	0.6
Diabetes (father)	3.1	3.9	9.4	1.8	3.1	-1.9	2.2	0.7	1.2
Diabetes (mother)	0.9	1.2	3.6	1.9	0.5	-0.5	1.3	-0.1	1.1
Severe depression (siblings)	2.3	2.5	3.6	0.2	1.9	-1.7	1.8	1.6	1.6
Pack years adult smoking proportion	1.0	1.5	2.3	-1.2	-1.5	1.0	-1.5	-0.7	-1.2
Impedance of leg (right)	0.1	0.3	1.2	-0.2	-0.6	-0.4	-0.3	1.1	0.1
Leg fat-free mass (left)	0.2	1.0	2.0	1.3	1.4	0.8	0.3	-1.2	0.2
Trunk fat percentage	0.4	1.8	5.2	2.3	1.0	-1.2	1.4	0.6	0.9
Hand grip strength (right)	1.5	4.1	6.2	-0.8	-1.3	2.3	-2.3	-2.5	-2.4
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.6	-0.2	-0.0	-0.5	-0.2	-0.8
Current tobacco smoking	1.0	1.7	3.9	-2.0	-1.9	1.0	-1.3	0.2	-0.3
Average weekly fortified wine intake	1.0	1.1	1.8	1.2	-0.1	-1.1	1.3	0.8	1.3
Maternal smoking around birth	0.3	0.5	1.5	1.2	0.6	-0.4	0.4	-0.8	-0.4
Fed-up feelings	0.1	0.3	0.8	-0.3	0.1	-0.9	0.2	0.7	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.0	0.7	-0.2	-1.1	1.4	0.9	1.0
Relative age voice broke	2.2	3.4	17.9	4.2	-0.6	0.5	0.3	-1.3	0.5
Taking other prescription medications	0.8	1.2	2.4	0.1	1.1	-1.5	1.3	1.1	0.7
Age when periods started (menarche)	1.2	2.9	13.0	3.6	1.0	0.1	1.0	-0.2	1.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.4	0.6	-0.5	0.9	-1.2	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	5.0	11.3	22.2	-1.0	-2.1	4.7	-4.0	-3.9	-3.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.8	-0.1	0.1	0.3	-0.8	-0.2
Qualifications: CSEs or equivalent	0.6	0.8	1.4	-0.3	1.2	-1.1	1.1	0.9	0.5
Serious illness, injury or assault to yourself	1.4	1.7	6.9	-2.6	-0.5	-0.6	-0.9	0.9	-1.0
High blood pressure	1.0	2.7	5.7	2.4	1.3	-1.4	2.1	0.2	1.4
Hayfever, allergic rhinitis or eczema	0.8	1.7	3.2	0.3	0.2	-1.8	1.6	1.6	1.2
Multivitamins +/- minerals	3.7	4.7	6.9	2.3	2.6	-2.3	2.5	1.4	1.6
Stomach or abdominal pain in last month	3.9	4.9	9.5	3.1	0.7	-1.8	3.1	0.7	2.5
Supplements: Glucosamine	2.5	3.3	5.5	1.7	1.3	-1.5	2.0	1.8	2.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.7	-0.9	0.5	-1.6	1.3	1.6	1.1
Medication: Atenolol	1.2	1.5	3.8	1.9	0.8	-0.9	1.7	-0.2	0.9
Medication: Levothyroxine sodium	1.1	1.8	5.1	-2.3	-0.5	1.0	-1.5	-0.6	-1.3
Sitting height	0.3	1.9	5.3	-0.8	-0.1	2.3	-1.4	-1.6	-0.6
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-0.2	0.9	-1.3	0.8	0.9	0.2
High blood pressure (mother)	2.6	3.7	8.6	1.3	1.3	-1.3	1.9	2.2	2.9
Body mass index (BMI)	0.1	0.5	1.4	1.2	0.7	-0.4	0.8	-0.1	0.4
Impedance of leg (left)	0.1	0.3	0.7	-0.1	-0.8	-0.6	-0.3	0.9	-0.3
Leg predicted mass (left)	0.2	0.9	1.8	1.2	1.4	0.8	0.3	-1.2	0.2
Trunk fat mass	0.3	1.2	4.1	2.0	1.3	-0.5	1.0	0.0	0.6
Waist circumference	0.1	0.4	1.4	1.2	0.9	-0.0	0.3	0.0	0.3
Number of incorrect matches in round	1.9	3.2	6.5	-1.4	-1.2	1.4	-2.0	-1.8	-2.6
Past tobacco smoking	3.3	6.0	11.4	-2.8	-3.4	2.1	-2.7	-1.1	-2.0
Alcohol usually taken with meals	0.4	0.7	1.9	-1.4	0.3	0.1	-1.1	0.6	-0.7
Nervous feelings	0.2	0.4	1.2	1.1	-0.1	-0.5	0.3	0.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	2.6	0.8	0.2	-1.0	1.1	1.6	1.6
Hearing difficulty/problems with background noise	0.2	0.3	0.9	0.4	0.3	-1.0	0.4	0.6	0.1
Hair/balding pattern: Pattern 2	1.3	1.7	4.1	1.3	2.0	-0.0	0.6	1.2	1.6
Had menopause	0.4	0.5	1.3	-0.2	0.1	0.4	-1.0	-0.6	-1.2
Had other major operations	0.5	0.6	1.8	1.3	-0.1	0.2	0.6	-0.1	1.1
Forced vital capacity (FVC)	0.3	1.2	3.9	0.2	-0.6	2.0	-0.2	-1.4	1.0
Heel bone mineral density (BMD) T-score, automated (right)	2.6	5.9	10.4	-1.2	-1.9	3.2	-3.2	-2.1	-2.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.1	-0.2	-0.1	-1.4	1.0	0.8	0.2
Qualifications: None of the above	0.3	0.5	1.3	-0.9	-0.6	-0.5	-0.6	0.3	-1.1
Financial difficulties in last 2 years	0.4	0.5	1.1	-0.7	-1.0	-0.7	-0.2	0.1	-0.9
Mouth/teeth dental problems	0.5	0.7	1.6	-0.3	-1.2	1.3	-1.0	-0.4	-0.1
Heart attack	0.2	0.3	0.4	0.5	0.7	0.1	-0.4	-0.5	-0.7
Allergy	0.9	2.1	5.2	0.4	-0.5	2.3	-1.8	-1.7	-0.9
Pain all over the body in last month	1.2	1.2	3.2	0.5	0.6	-1.0	1.8	0.7	1.5
Diabetes (self-reported)	0.2	0.4	1.2	-0.5	0.5	1.1	-0.4	0.0	0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	0.5	-0.1	-0.8	0.8	0.0	0.1
Medication: Ramipril	1.0	1.3	2.5	1.2	0.8	-0.7	1.4	0.9	1.6
Medication: Simvastatin	0.4	0.6	1.2	-0.6	-0.9	0.2	-0.9	-0.5	-1.1
Fluid intelligence score	2.4	5.0	10.6	3.3	1.8	-1.0	2.5	0.6	2.9
Illnesses of siblings	0.5	0.7	1.2	-1.1	0.0	0.3	-0.6	-1.1	-1.1
Neuroticism score	0.1	0.3	1.2	1.1	-0.3	-0.3	-0.2	0.7	-0.0
Weight	0.1	0.7	1.9	1.4	1.1	0.6	0.2	-0.8	0.2
Impedance of arm (right)	0.8	3.5	4.2	2.0	0.6	-2.0	2.1	2.0	2.0
Arm fat percentage (right)	0.4	1.5	4.0	2.0	0.7	-1.1	1.4	0.7	1.0
Trunk fat-free mass	0.4	2.1	4.1	-0.4	0.7	2.0	-1.4	-2.0	-1.3
Hip circumference	0.4	1.6	4.4	2.1	1.4	-0.6	1.4	0.0	1.2
Time employed in main current job	0.3	0.3	0.8	-0.5	-0.9	-0.1	-0.5	0.8	0.0
Alcohol intake versus 10 years previously	0.5	0.7	1.2	0.3	1.1	1.1	-0.9	-0.7	-0.6
Father’s age at death	0.6	0.8	1.4	-0.5	-0.5	0.9	-1.0	-1.2	-1.1
Worrier / anxious feelings	0.4	0.7	1.7	0.6	0.2	-0.9	0.7	1.3	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.1	0.3	0.7	-0.7	0.5	1.0	0.5
Falls in the last year	0.6	0.8	1.8	-0.5	1.4	-1.1	0.4	-0.2	-1.0
Hair/balding pattern: Pattern 3	0.7	1.0	2.3	-0.5	0.7	-1.2	0.7	1.5	0.9
Number of live births	0.2	0.3	1.1	1.1	-0.6	0.1	-0.3	-0.3	-0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.8	0.3	-0.2	1.2	0.2	-1.4	0.6
Pulse rate	0.1	0.2	0.6	-0.4	-0.1	0.6	-0.7	0.5	0.3
Happiness	0.5	0.6	2.4	-1.6	-0.8	0.8	-0.5	-0.0	0.0
Noisy workplace	0.3	0.3	0.8	-0.9	-0.4	0.4	-0.5	-0.5	-0.7
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.5	2.3	0.4	0.7	1.0	-0.2	2.1
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	4.3	0.3	2.1	-1.0	0.9	-0.0	-0.0
Mouth/teeth dental problems: Dentures	0.2	0.4	1.6	-0.1	1.3	-0.7	0.4	-0.1	-0.4
Asthma	0.7	1.4	4.0	-0.0	0.6	-2.0	1.3	1.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.4	0.3	0.4	-1.5	1.2	1.9	1.2
Medication: Cholesterol lowering	0.9	1.4	2.7	-0.4	-0.7	1.0	-1.6	-1.1	-1.6
Depression (self-reported)	1.7	2.1	7.4	2.7	-0.3	-0.8	1.5	0.4	1.4
Medication: Lansoprazole	2.3	2.6	4.1	-1.0	-1.0	2.0	-2.0	-1.6	-1.6
Prospective memory result	0.5	0.7	2.1	-0.5	0.5	-1.4	0.4	1.0	-0.4
Lung cancer (father)	1.3	1.6	2.4	-0.1	-0.8	1.6	-1.4	-1.6	-1.4
Illnesses of mother	3.0	3.7	5.4	-1.7	-1.1	2.0	-2.3	-1.8	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	0.6	-0.1	0.6	0.6	-0.6	1.0
Pulse wave Arterial Stiffness index	0.8	0.9	2.8	-0.4	1.7	1.3	-0.6	-0.2	0.7
Impedance of arm (left)	0.5	2.2	3.3	1.8	0.2	-1.5	1.6	1.6	1.6
Arm fat mass (right)	0.2	0.8	2.4	1.6	0.9	-0.4	0.9	-0.0	0.6
Trunk predicted mass	0.3	2.0	4.1	-0.4	0.6	2.0	-1.4	-1.9	-1.2
Standing height	0.1	1.4	3.8	0.6	1.2	2.0	-1.0	-1.4	-0.1
Length of working week for main job	3.3	3.7	7.1	-0.4	0.4	-2.7	2.2	2.6	1.7
Exposure to tobacco smoke at home	0.6	0.6	1.8	0.8	1.4	-0.5	0.8	-0.1	0.5
Breastfed as a baby	0.2	0.3	0.9	0.2	-0.7	-0.3	-0.2	-0.3	-0.9
Tense / ‘highly strung’	0.7	1.2	3.1	1.8	1.2	-0.4	0.6	0.8	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	4.7	7.2	11.8	1.9	1.1	-3.4	3.1	3.1	2.6
Hair/balding pattern: Pattern 4	3.4	8.2	13.2	-1.0	-3.4	3.0	-2.7	-3.6	-2.7
Birth weight of first child	1.3	2.3	4.0	0.5	-1.4	2.0	-1.7	-1.8	-1.2
Peak expiratory flow (PEF)	0.6	1.4	3.2	1.8	0.7	-0.0	1.4	-0.6	1.6
Pulse wave reflection index	0.5	0.6	1.8	0.7	1.4	0.1	0.5	0.2	1.1
Ever highly irritable/argumentative for 2 days	2.4	2.8	5.5	0.5	1.2	-2.1	1.7	2.3	1.6
Loud music exposure frequency	0.5	0.5	2.2	1.5	0.1	-0.6	0.6	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	3.1	4.9	12.0	3.5	1.7	-1.0	2.5	0.6	2.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.3	-0.2	0.2	-1.1	0.9	0.7	0.5
Blood clot in the leg (DVT)	0.5	0.6	1.7	-1.3	-0.6	-0.8	0.6	0.8	0.5
Medication: Paracetamol	0.1	0.2	1.0	0.3	1.0	-0.0	0.4	0.1	0.5
Headache pain in last month	3.2	5.5	9.1	2.1	2.0	-1.8	2.3	2.6	3.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.1	-0.7	0.6	-0.2	0.2	1.0	0.8
Glaucoma (self-reported)	1.0	1.2	2.7	-1.6	-0.8	-0.8	-0.7	1.0	-1.2
Gout (self-reported)	3.0	4.1	6.5	1.4	1.4	-2.5	2.3	2.1	2.0
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	3.9	-2.0	-0.6	1.2	-1.7	-1.1	-2.0
Medication: Amlodipine	0.4	0.6	1.5	0.7	-1.0	-0.5	-0.3	-0.5	-1.2
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.8	-0.9	0.2	-0.7	0.5	-0.2	-0.6
Birth weight	1.0	2.2	4.2	-0.0	-0.3	1.5	-1.9	-1.7	-2.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.0	-1.4	0.3	-0.8	0.8	1.7	1.5
High blood pressure (siblings)	0.4	0.6	1.6	1.3	-0.2	0.2	-0.0	1.1	0.9
Forced vital capacity (FVC), Best measure	0.1	0.4	1.0	0.3	-0.2	0.9	0.3	-0.5	1.0
Body fat percentage	0.3	1.3	4.3	2.1	0.8	-1.1	1.1	0.5	0.6
Leg fat percentage (right)	0.0	0.1	0.5	0.7	0.1	-0.4	0.1	0.2	-0.1
Arm fat-free mass (right)	0.2	1.2	2.5	-0.2	0.8	1.6	-1.0	-1.5	-0.8
Exposure to tobacco smoke outside home	0.2	0.3	0.7	-0.0	0.8	-0.1	0.0	-0.8	-0.7
Comparative body size at age 10	0.5	1.3	2.4	1.5	0.8	-0.8	1.5	0.4	1.3
Number of full brothers	0.4	0.5	1.6	-1.3	0.2	-0.5	-0.3	0.8	-0.3
Worry too long after embarrassment	0.6	0.9	3.7	1.9	-0.8	0.1	0.1	0.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	4.1	5.3	9.0	1.0	0.5	-3.0	2.7	2.9	2.4
Wheeze or whistling in the chest in last year	1.3	2.4	5.8	-1.0	0.3	-1.8	1.4	2.4	1.4
Number of children fathered	0.3	0.3	1.1	1.1	-0.5	-0.4	0.0	-0.2	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.3	-0.1	-0.5	0.3	0.3	0.2
Age at first live birth	0.2	0.4	0.8	-0.7	0.7	0.4	-0.1	0.7	0.9
Pulse wave peak to peak time	0.7	0.8	2.5	0.2	-1.6	-1.2	0.5	0.2	-0.7
Health satisfaction	1.3	1.7	6.6	-2.6	0.1	1.0	-1.4	0.3	-0.8
Shortness of breath walking on level ground	0.4	0.4	1.5	-0.3	1.2	-0.7	0.1	0.6	-0.3
Qualifications: College or University degree	0.2	0.7	2.7	-0.7	-0.2	1.6	-0.8	-0.3	0.7
Eye problems/disorders: None of the above	1.2	1.4	2.7	1.6	-0.9	1.7	-1.1	-1.1	0.1
Mouth/teeth dental problems: Loose teeth	1.7	2.0	4.5	0.3	1.6	-0.8	1.7	1.2	2.1
Emphysema/chronic bronchitis	1.2	1.4	3.2	-1.6	0.6	-1.1	0.6	1.8	0.7
Medication for pain relief, constipation, heartburn	0.3	0.6	1.4	1.2	-0.5	-0.2	0.8	-1.0	0.2
Neck or shoulder pain in last month	0.7	1.0	5.8	0.7	2.4	-0.2	0.2	-0.2	-0.1
Medication: Blood pressure	0.2	0.3	0.9	0.9	-0.0	0.2	0.4	-0.8	0.1
Angina (self-reported)	0.2	0.2	0.9	-1.0	-0.5	0.2	-0.0	0.1	0.2
Migraine (self-reported)	0.4	0.5	1.8	1.4	-0.1	0.0	0.5	0.5	1.0
Medication: Ibuprofen	1.2	1.4	2.5	0.7	0.8	-1.6	1.3	1.5	0.9
Medication: Allopurinol	2.8	3.8	5.3	1.7	1.6	-2.3	2.2	1.9	1.9
Medication: Omeprazole	0.2	0.3	0.8	-0.9	0.4	0.4	-0.6	0.4	0.0
Medication: Seretide 50 evohaler	0.3	0.4	1.3	-0.4	0.1	-1.1	0.9	0.2	-0.0
Mean time to correctly identify matches	1.6	3.0	6.2	-2.5	-1.5	0.9	-2.2	0.1	-1.9
Heart disease (mother)	0.1	0.2	0.9	0.1	0.9	0.2	-0.1	-0.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.9	0.8	-1.0	0.0	0.5	-0.9	0.0
Whole body fat mass	0.2	0.8	2.9	1.7	1.1	-0.4	0.7	-0.1	0.4
Leg fat mass (right)	0.1	0.4	1.3	1.0	1.1	-0.3	0.5	-0.2	0.1
Arm predicted mass (right)	0.3	1.3	2.5	-0.3	0.9	1.6	-1.0	-1.6	-0.9
Pulse rate, automated reading	0.2	0.8	1.7	-1.0	-0.3	0.3	-0.1	1.3	1.3
Alcohol intake frequency.	1.0	2.2	6.0	2.4	1.3	-0.5	1.7	-0.1	1.6
Comparative height size at age 10	0.6	3.0	4.8	-2.1	0.3	2.1	-2.2	-1.4	-1.6
Number of full sisters	0.5	0.6	2.6	-1.6	0.1	-0.5	-0.4	0.3	-0.8
Suffer from ‘nerves’	0.4	0.6	2.3	1.5	-0.3	-0.6	0.2	0.8	0.3
Overall health rating	0.1	0.2	0.6	-0.1	-0.8	0.2	-0.3	0.7	0.1
Chest pain or discomfort	1.2	1.7	3.5	0.4	0.6	-1.9	1.8	1.3	1.1
Had major operations	0.6	0.7	2.4	-1.0	1.5	-0.4	-0.1	-0.1	-0.8
Age at last live birth	0.5	0.7	1.1	-0.9	0.8	-0.3	0.6	1.1	1.1
Family relationship satisfaction	0.2	0.2	0.5	-0.6	-0.5	-0.5	0.0	-0.0	-0.7
Leg pain on walking	1.1	1.4	3.0	-1.5	-0.3	1.6	-1.7	-0.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	-0.5	-0.7	0.5	-0.0	-0.8	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.5	1.2	-0.5	0.9	-0.2	-0.5	0.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.1	0.7	-0.1	1.1	0.2	-0.2	1.5
Medication: Aspirin	0.1	0.1	0.4	-0.3	0.1	0.4	-0.6	0.1	-0.3
Supplements: Vitamin C	4.7	5.6	8.5	1.8	2.9	-1.9	2.8	1.5	2.7
Knee pain experienced in last month	0.3	0.4	1.6	0.4	1.3	-0.5	0.3	0.5	0.3
Hypertension (Self-reported)	1.1	3.0	5.4	2.1	1.5	-1.8	2.3	0.8	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.2	3.3	-1.0	-1.6	1.8	-1.8	-1.2	-1.2
Illnesses of father: Heart disease	0.9	1.2	2.8	1.7	0.0	-1.5	1.4	0.2	0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.7	1.3	0.7	0.2	0.2	-0.1	0.4
Smoking status: Previous	3.9	5.8	14.8	2.5	3.9	-2.1	2.6	0.9	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.3	0.5	0.7	0.1	0.9	0.8	1.5
Whole body fat-free mass	0.2	1.2	3.0	0.3	0.8	1.5	-0.7	-1.7	-0.7
Leg fat-free mass (right)	0.2	0.8	1.7	1.0	1.3	0.8	0.3	-1.3	0.0
Arm fat percentage (left)	0.4	1.5	4.0	2.0	0.7	-1.0	1.4	0.6	1.0
Average weekly red wine intake	0.7	1.1	2.4	-1.5	-0.1	0.8	-1.3	-0.4	-1.2
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.7	-1.2	0.2	1.5	-1.6	0.1	-0.4
Mood swings	0.5	0.9	2.7	1.0	-0.2	0.4	-1.1	-0.8	-1.6
Loneliness, isolation	0.3	0.4	0.9	0.5	-1.0	-0.6	-0.2	0.7	-0.4
Long-standing illness, disability or infirmity	0.2	0.3	1.0	0.3	-0.4	-0.6	0.0	1.0	0.2
Ever had bowel cancer screening	3.4	4.0	7.5	0.6	1.9	-2.7	2.1	2.4	1.5
Diabetes diagnosed by doctor	0.2	0.4	1.4	-0.1	0.5	1.2	-0.3	-0.2	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.5	0.3	0.1	-1.1	1.2	-0.3	-0.0
Friendships satisfaction	1.3	1.7	4.5	-2.1	-1.4	-0.6	0.7	1.2	1.1
Qualifications: nursing, teaching	0.5	0.7	2.3	-0.4	-0.6	1.5	-0.4	-0.1	1.1
Commuting to job workplace: Walk	0.5	0.6	2.9	-1.7	-0.1	-0.2	-0.4	0.5	-0.3
Eye problems/disorders: Cataract	2.1	2.5	5.3	-0.4	1.0	-1.7	1.6	2.3	1.7
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	7.2	2.7	1.5	-1.4	1.8	0.6	1.1
Medication for cholesterol	1.1	1.6	2.6	-0.6	-1.1	1.4	-1.3	-1.6	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.8	1.7	1.4	-1.1	0.8	0.5	0.3
Back pain experienced in last month	1.4	2.0	3.5	-0.5	-0.1	1.9	-1.8	-1.7	-1.5
Mineral and other dietary supplements	1.2	1.6	3.2	-1.8	-1.5	0.6	-1.2	-0.5	-1.3
Breast cancer (self-reported)	0.4	0.5	1.1	-1.1	0.6	-0.7	0.6	0.8	0.4
Asthma (self-reported)	0.7	1.5	3.8	-0.2	0.6	-1.9	1.3	1.7	0.5
Osteoporosis (self-reported)	4.0	4.9	9.9	3.1	2.9	-1.5	2.3	0.7	1.9
Osteoarthritis (self-reported)	1.1	1.4	4.4	-2.1	-0.1	-0.3	-1.2	1.2	-1.1
Medication: Aspirin	0.5	0.7	1.5	-0.4	-0.4	1.0	-1.2	-0.6	-0.9
Medication: Gliclazide	1.3	1.5	3.4	-1.3	-1.9	1.6	-1.1	-0.3	0.2
Illnesses of father: None of the above (group 1)	1.3	1.6	3.8	-0.6	-0.8	1.9	-1.9	-0.8	-0.8
Smoking status: Current	0.7	1.1	3.1	-1.6	-1.8	0.6	-0.8	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.6	0.4	0.0	0.1	0.5	-0.3	0.7
Whole body water mass	0.2	1.2	3.0	0.0	0.6	1.7	-0.9	-1.7	-0.7
Leg predicted mass (right)	0.2	0.9	1.7	1.1	1.3	0.8	0.3	-1.3	0.1
Arm fat mass (left)	0.2	0.7	1.7	1.3	0.9	-0.5	0.9	0.3	0.7
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.1	-0.2	-0.4	0.1	-0.5	-0.8
Average weekly champagne plus white wine intake	0.2	0.3	1.5	-1.2	0.1	-0.3	-0.1	0.1	-0.5
Miserableness	1.2	2.0	5.5	0.5	1.1	-1.5	1.0	2.3	1.3
Guilty feelings	1.8	2.7	6.0	0.9	0.1	-2.4	2.0	2.0	1.2
Wears glasses or contact lenses	0.7	0.8	2.6	1.6	1.0	-0.3	0.5	0.5	0.8
Ever taken oral contraceptive pill	1.2	1.3	2.7	0.6	1.6	-0.8	1.6	0.2	1.2
Hearing aid user	0.1	0.1	0.2	-0.0	0.3	-0.2	-0.3	-0.0	-0.5
Mother’s age at death	0.2	0.3	1.1	-1.1	0.0	-0.1	-0.5	0.3	-0.5
Financial situation satisfaction	0.2	0.2	1.0	-1.0	0.2	-0.4	0.0	0.3	-0.4
Tinnitus: Yes, now most or all of the time	2.6	3.0	6.5	-1.7	-0.8	1.2	-2.4	-1.0	-2.5
Commuting to job workplace: Public transport	0.9	1.1	2.5	-1.6	-0.9	1.0	-1.4	-0.1	-0.6
Eye problems/disorders: Glaucoma	1.7	2.0	4.5	-1.8	0.4	-2.1	0.4	1.8	-0.8
Medication: Blood pressure	0.3	0.6	1.4	0.4	0.3	-0.8	0.8	1.2	0.9
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.2	0.3	-0.1	-0.1	0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.5	1.9	0.5	-0.8	1.2	0.2	0.7
High cholesterol (Self-reported)	0.7	1.3	3.1	-0.2	-0.9	0.8	-1.3	-1.1	-1.8
Medication: Bendroflumethiazide	0.1	0.2	0.4	-0.1	-0.0	0.7	-0.6	-0.5	-0.5
Medication: Paracetamol	0.5	0.7	2.3	0.6	1.5	-0.1	0.6	0.6	0.9
Medication: Lisinopril	0.3	0.3	1.4	0.3	0.2	0.6	-0.1	-1.2	-0.4
Medication: Atorvastatin	0.1	0.1	0.4	-0.4	-0.0	-0.1	-0.0	0.6	0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.5	0.5	-0.1	0.0	0.3	0.1
Alcohol drinker status: Never	3.7	4.4	7.2	2.2	2.1	-1.6	2.7	1.1	2.4
Ever smoked	3.3	5.8	10.8	3.3	2.7	-1.7	2.7	0.9	2.4
Basal metabolic rate	0.2	1.0	2.3	0.5	0.9	1.4	-0.5	-1.5	-0.4
Leg fat percentage (left)	0.1	0.2	0.8	0.9	-0.2	-0.5	0.2	0.1	-0.2
Arm fat-free mass (left)	0.2	0.8	1.9	-0.5	0.3	1.4	-1.0	-1.1	-0.7
Number of operations (self-reported)	1.0	1.4	2.4	0.7	1.0	-1.6	1.4	1.4	1.0
Average weekly beer plus cider intake	0.2	0.2	0.4	0.3	-0.7	-0.2	0.2	0.6	0.6
Irritability	1.3	2.3	3.9	2.0	1.7	-0.9	1.3	1.1	1.7
Risk taking	0.7	1.0	1.9	0.2	1.0	-1.4	1.3	0.7	0.8
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	-0.8	-0.4	-0.4	0.3	0.6	0.3
Fractured/broken bones in last 5 years	0.4	0.5	1.6	-0.2	0.7	-1.3	0.4	0.6	-0.4
Age started oral contraceptive pill	0.2	0.3	1.0	0.8	1.0	0.1	-0.2	-0.3	-0.3
Diastolic blood pressure, automated reading	0.1	0.3	0.8	0.3	-0.8	-0.2	0.9	-0.2	0.5
Ever depressed for a whole week	0.3	0.4	0.8	-0.3	-0.7	-0.7	0.4	0.9	0.2
Unable to work because of sickness or disability	1.2	1.6	3.1	0.4	-0.2	-1.3	1.7	1.3	1.8
Commuting to job workplace: Cycle	0.9	1.1	2.9	-1.7	-0.2	0.5	-0.6	1.4	1.0
Myopia	1.8	2.6	6.0	2.4	0.6	-0.6	2.0	0.2	2.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	4.6	-2.1	-1.5	1.3	-1.8	0.1	-1.0
Cholesterol lowering medication	0.3	0.5	1.2	-1.0	-0.6	0.0	-0.6	-0.3	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.6	-0.3	0.6	-0.1	0.1	0.7	0.7
Pain experienced in last month	0.6	1.1	3.6	-0.5	-1.9	0.5	-0.4	-1.2	-0.9
Supplements: Calcium	4.7	5.2	8.4	2.7	1.7	-1.7	2.9	1.4	2.9
Basal cell carcinoma (self-reported)	1.0	1.2	2.2	-0.7	0.3	-1.2	1.2	1.5	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.6	0.7	0.2	-0.5	-0.8	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	-1.2	-0.4	-1.0	0.9	0.8	0.6
Heart disease (siblings)	0.1	0.1	0.3	0.1	-0.6	0.2	-0.2	-0.4	-0.3
Alcohol drinker status: Previous	0.4	0.4	0.7	0.6	0.7	0.6	-0.4	-0.9	-0.6
Pack years of smoking	0.5	0.7	1.4	-0.6	-1.0	0.7	-1.2	-0.5	-0.8
Impedance of whole body	0.3	1.5	2.8	1.2	0.1	-1.5	1.2	1.7	1.2
Leg fat mass (left)	0.1	0.3	0.9	1.0	0.9	-0.2	0.3	-0.2	0.0
Arm predicted mass (left)	0.3	1.3	2.9	-0.4	0.4	1.7	-1.2	-1.5	-1.0