Hub : Genes

MZT1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1650	0.0580	2.2e-03	-0.003	NA	0.001	NA	0.000	5.1e-01	NA	0.29000	NA	0.31000
2	GTEx	Muscle Skeletal	0.0768	0.0305	3.5e-03	0.058	NA	0.028	NA	0.037	2.3e-06	NA	0.00076	NA	0.00014
3	METSIM	Adipose	0.0802	0.0235	1.8e-05	0.003	0.025	0.010	0.005	0.007	9.6e-02	9e-05	0.01100	0.049	0.02800

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.7	0.3	0.5	1.3
Bipolar Disorder or Schizophrenia	0.6	1.4	2.9	-1.7	-1.1	-0.3
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	0.6	1.5	-0.2
Depression (Nagel 2018)	0.1	0.1	0.2	0.4	0.1	-0.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.0	1.4	0.6	1.0
Neuroticism (Nagel 2018)	0.5	1.1	2.3	-0.0	1.5	-1.0
Schizophrenia (2018)	1.6	3.3	5.4	-2.3	-1.8	-1.1
Schizophrenia vs Biploar Disorder	0.7	0.9	1.8	-1.3	-0.7	-0.8
Worry (Nagel 2018)	0.5	1.1	2.5	-0.2	1.6	-0.8
Alzheimer’s Disease (in mother)	1.5	1.7	4.4	-2.1	-0.8	0.4
Alzheimer’s Disease (in father)	3.8	4.1	6.2	-2.5	-2.2	-1.3
Alzheimer’s Disease (including proxy)	3.6	5.2	9.7	-3.1	-2.1	-1.1
Crohns Disease (2017)	3.0	6.5	10.9	-3.3	-2.2	-1.9
Irritable Bowel Disease (IBD)	1.4	3.4	5.3	-2.3	-1.3	-1.8
Ulcerative Colitis (UC)	1.0	1.8	3.4	-1.4	-0.1	-1.8
Major Depression (MDD)	1.0	1.2	2.8	-0.7	-1.7	-0.6
Reaction Time	0.5	0.9	2.4	0.3	-0.4	1.5
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.8	1.7	0.1	0.5
Breast Cancer	0.5	1.3	3.4	-0.3	-1.9	-0.6
Ovarian Cancer	0.4	0.6	0.9	0.2	-0.9	-0.9
Prostate Cancer	6.0	8.5	12.0	3.0	3.5	2.2
Age at First Birth	0.9	1.3	3.9	-0.3	-2.0	0.3
Bipolar Disorder (2011)	1.9	1.8	2.0	-1.4	-1.4	-1.3
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.7	0.3	0.3
Coronary Artery Disease (CAD)	0.8	0.9	1.0	1.0	1.0	0.9
Crohns Disease (2012)	3.0	4.9	7.9	-2.3	-1.3	-2.8
Mean Putamen Volume	3.1	3.5	6.7	1.9	2.6	0.2
Fasting Glucose	1.6	1.9	4.0	-2.0	0.1	-1.3
HbA1C	0.0	0.1	0.1	-0.3	-0.2	-0.2
HDL Cholesterol	0.3	0.5	1.3	1.1	0.4	0.3
LDL Cholesterol	0.4	0.6	1.0	0.5	1.0	-0.8
Lupus	0.5	0.7	1.4	1.2	0.7	0.5
Neuroticism (2016)	0.1	0.1	0.2	0.5	0.1	0.1
Primary Biliary Cirrhosis	1.3	1.9	4.1	0.7	-1.1	2.0
Rheumatoid Arthritis	4.6	6.4	15.3	1.9	3.9	-0.0
Schizophrenia (2014)	1.9	4.3	8.7	-3.0	-1.6	-1.2
Triglycerides	0.7	1.1	1.4	-0.8	1.2	-1.2
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.3	-0.4	-0.6	0.1
Ulcerative Colitis	0.6	0.8	2.0	-0.7	-0.2	-1.4
Blood Eosinophil Count	1.6	12.0	21.4	-2.9	-4.6	-2.5
Blood Platelet Count	0.6	7.3	14.0	-2.5	-1.3	-3.7
Blood Red Count	0.1	1.4	3.3	0.1	-0.9	1.8
Blood White Count	0.0	0.3	0.9	0.9	-0.3	0.3
Heel T-Score	0.1	0.7	1.3	1.1	-0.4	0.7
BMI	0.1	0.4	0.9	-0.9	0.3	0.5
Height	0.5	9.6	14.3	-3.7	1.1	-3.8
Waist Hip Ratio (WHR)	0.5	2.3	4.8	-1.4	0.0	-2.2
Systolic Blood Pressure	0.2	0.8	2.4	0.1	1.5	0.3
Smoking Status	0.3	0.7	2.0	0.2	1.4	-0.1
Allergy or Eczema	2.5	6.7	7.9	-2.4	-2.5	-2.8
Cardiovascular Disease	0.1	0.2	0.4	0.6	0.5	0.3
Hypothyroidism (self reported)	0.2	0.5	1.3	0.2	-0.4	1.1
Respiratory disease	2.0	4.3	9.0	-1.9	-0.5	-3.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	-0.7	0.2	-0.8
Lung FEV1/FVC ratio	1.2	5.9	6.8	-2.6	2.6	-2.1
Lung FVC	2.4	12.1	26.9	5.2	2.0	2.4
Neuroticism	0.4	1.0	2.1	-1.5	0.1	-0.9
Chronotype (morning person)	4.5	10.4	22.4	-3.0	0.2	-4.7
Hair Pigment	0.1	3.2	3.7	-1.9	-1.5	1.9
Tanning	0.0	0.1	0.2	0.5	0.1	-0.1
Hand grip strength (left)	0.6	1.5	2.9	1.1	1.7	-0.5
Number of treatments/medications taken	0.0	0.0	0.1	0.2	-0.0	-0.3
Average weekly spirits intake	0.2	0.3	0.6	0.3	0.3	-0.8
Sensitivity / hurt feelings	1.2	2.0	3.1	0.2	1.7	-1.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.3	0.2	0.1	1.1
Hearing difficulty/problems: Yes	1.1	1.7	2.5	1.1	1.6	1.1
Relative age of first facial hair	0.7	1.4	4.0	0.3	0.4	2.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	1.1	0.2	0.8
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	-0.5	0.2	0.3
Ever had hysterectomy (womb removed)	0.7	0.8	1.9	-0.6	1.4	0.4
Systolic blood pressure, automated reading	0.5	1.3	2.2	0.2	1.5	1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.7	-0.5	-0.3	-1.6
Angina	2.6	3.4	9.1	0.9	3.0	0.6
Medication for hormone replacement therapy	1.4	1.6	2.7	-1.7	-1.4	0.4
Vitamin and mineral supplements	0.8	1.1	3.1	0.1	0.4	1.8
Supplements: Zinc	0.1	0.1	0.2	0.2	0.2	0.4
Medication: Co-codamol	2.0	2.3	3.9	-1.6	0.7	-2.0
Medication: Metformin	0.2	0.2	0.4	-0.4	0.6	-0.3
Diabetes (father)	1.0	1.2	2.1	-1.4	0.4	-1.2
Diabetes (mother)	0.6	0.7	0.9	0.7	0.9	-1.0
Severe depression (siblings)	0.4	0.4	0.9	-1.0	0.4	-0.4
Pack years adult smoking proportion	0.2	0.3	0.6	-0.3	0.5	0.8
Impedance of leg (right)	0.2	0.8	1.3	-1.1	-1.0	-0.4
Leg fat-free mass (left)	0.2	0.9	1.4	-1.2	0.7	-0.9
Trunk fat percentage	0.3	1.0	2.7	-1.6	0.1	0.6
Hand grip strength (right)	0.3	0.7	1.6	0.7	1.3	-0.2
Townsend deprivation index at recruitment	1.4	2.0	4.1	1.3	0.6	2.0
Current tobacco smoking	0.1	0.2	0.4	0.3	0.6	-0.1
Average weekly fortified wine intake	0.2	0.2	0.6	-0.2	0.8	-0.2
Maternal smoking around birth	0.4	0.5	1.1	-0.1	1.1	-0.7
Fed-up feelings	0.5	0.9	1.9	-0.7	-0.5	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.5	-0.7	0.0	-0.0
Relative age voice broke	1.0	1.5	4.3	-0.1	0.5	2.1
Taking other prescription medications	1.4	2.2	5.4	1.0	2.3	-0.4
Age when periods started (menarche)	0.2	0.6	1.5	1.2	-0.2	-0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.6	-0.8	-0.1	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	3.6	1.5	0.2	1.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.6	-0.7	0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.6	-0.2	0.4	-1.3
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.3	-0.9	-0.5
High blood pressure	0.2	0.6	0.7	-0.7	0.8	-0.8
Hayfever, allergic rhinitis or eczema	1.6	3.5	5.4	-1.4	-2.3	-1.8
Multivitamins +/- minerals	1.3	1.6	3.4	-0.5	-1.1	-1.8
Stomach or abdominal pain in last month	0.6	0.7	1.3	-0.4	0.8	-1.1
Supplements: Glucosamine	0.4	0.5	1.1	-0.0	-0.6	-1.1
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.8	-0.9	0.2	-1.4
Medication: Atenolol	0.9	1.2	1.7	0.9	1.3	1.1
Medication: Levothyroxine sodium	0.0	0.0	0.1	-0.0	0.3	-0.2
Sitting height	0.8	5.6	8.4	-2.9	-1.8	-2.3
Chronic bronchitis/emphysema (father)	2.6	3.0	3.8	2.0	1.3	1.8
High blood pressure (mother)	1.2	1.7	4.5	-2.1	-0.4	0.8
Body mass index (BMI)	0.2	0.8	1.2	-0.3	1.1	1.1
Impedance of leg (left)	0.1	0.5	0.8	-0.7	-0.9	-0.5
Leg predicted mass (left)	0.2	0.9	1.3	-1.1	0.8	-0.8
Trunk fat mass	0.2	1.0	2.8	-1.7	0.3	0.1
Waist circumference	0.2	0.9	1.5	-1.2	1.0	-0.5
Number of incorrect matches in round	0.4	0.6	1.1	-1.0	0.8	-0.2
Past tobacco smoking	0.6	1.1	3.1	0.4	-1.8	0.4
Alcohol usually taken with meals	1.0	1.7	3.0	-1.7	-1.0	-1.0
Nervous feelings	1.4	2.6	6.6	1.1	2.6	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	0.2	1.0	0.0
Hearing difficulty/problems with background noise	2.0	3.2	6.6	1.3	2.6	1.2
Hair/balding pattern: Pattern 2	5.3	6.7	13.6	-3.7	-0.3	-2.5
Had menopause	0.2	0.3	0.7	-0.4	0.3	0.8
Had other major operations	0.3	0.4	0.9	-1.0	0.2	0.3
Forced vital capacity (FVC)	0.6	2.2	3.4	1.7	1.9	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.0	0.8	-0.1	1.7
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-1.1	0.1	0.8
Qualifications: None of the above	0.4	0.8	1.7	-0.9	0.1	-1.3
Financial difficulties in last 2 years	2.1	2.8	6.4	-1.4	-2.5	0.2
Mouth/teeth dental problems	0.1	0.2	0.4	0.6	-0.5	0.2
Heart attack	3.2	4.1	8.2	1.8	2.9	-1.0
Allergy	1.0	2.2	4.0	1.5	0.5	2.0
Pain all over the body in last month	2.2	2.4	6.2	0.9	2.5	0.0
Diabetes (self-reported)	0.3	0.5	1.5	-0.2	1.2	0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.2	-0.3	0.4
Medication: Ramipril	0.9	1.2	3.0	0.7	1.7	-0.1
Medication: Simvastatin	1.4	2.0	4.4	2.1	1.1	-0.7
Fluid intelligence score	0.2	0.4	1.0	0.2	-1.0	0.1
Illnesses of siblings	0.2	0.3	0.6	0.0	-0.6	-0.8
Neuroticism score	0.2	0.5	1.0	0.0	1.0	-0.7
Weight	0.2	0.9	1.5	-1.2	1.0	-0.1
Impedance of arm (right)	0.2	1.1	1.8	-1.2	-1.3	-0.4
Arm fat percentage (right)	0.2	0.9	1.5	-1.2	0.1	1.1
Trunk fat-free mass	0.2	1.2	1.7	-1.2	0.6	-1.3
Hip circumference	0.2	0.7	2.0	-1.4	-0.0	0.1
Time employed in main current job	0.8	0.9	2.2	0.4	1.5	0.5
Alcohol intake versus 10 years previously	0.8	1.2	2.1	1.0	-0.6	1.4
Father’s age at death	1.8	2.4	6.1	-2.5	-0.8	-0.7
Worrier / anxious feelings	0.8	1.6	3.3	0.4	1.8	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.7	0.3	0.9	0.7
Falls in the last year	0.5	0.6	1.9	-0.0	1.4	0.3
Hair/balding pattern: Pattern 3	1.8	2.7	6.0	2.4	-0.4	1.4
Number of live births	0.2	0.3	0.5	-0.6	0.7	0.3
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.4	0.9	2.3	0.2
Pulse rate	0.7	1.2	2.5	0.5	1.6	-1.0
Happiness	1.1	1.3	3.7	-1.9	-0.5	-0.3
Noisy workplace	0.6	0.7	1.3	0.8	0.5	1.1
Qualifications: A levels/AS levels or equivalent	0.9	2.1	3.3	1.8	1.6	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	1.1	-0.6	1.0	-0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	1.8	0.3	1.3	1.4
Asthma	0.1	0.2	0.4	0.2	0.6	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.8	-0.4	-0.9	0.6
Medication: Cholesterol lowering	0.8	1.3	2.1	1.4	0.9	1.0
Depression (self-reported)	1.2	1.4	2.2	1.3	1.5	0.6
Medication: Lansoprazole	0.2	0.2	0.4	-0.6	0.3	-0.5
Prospective memory result	0.1	0.1	0.2	-0.2	0.3	0.5
Lung cancer (father)	1.5	1.7	3.9	0.9	0.8	2.0
Illnesses of mother	0.6	0.8	2.1	1.5	-0.5	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.0	0.8	2.2	0.4
Pulse wave Arterial Stiffness index	1.2	1.4	2.9	0.3	1.1	-1.7
Impedance of arm (left)	0.3	1.3	1.8	-1.4	-1.1	-0.9
Arm fat mass (right)	0.2	0.8	1.8	-1.3	0.6	0.5
Trunk predicted mass	0.2	1.3	1.9	-1.4	0.5	-1.3
Standing height	0.5	4.8	7.5	-2.6	-0.2	-2.7
Length of working week for main job	0.3	0.3	0.7	-0.2	-0.8	-0.5
Exposure to tobacco smoke at home	0.6	0.7	1.5	0.6	1.2	0.5
Breastfed as a baby	0.6	0.8	1.1	0.9	0.6	1.1
Tense / ‘highly strung’	0.6	1.0	1.6	-1.0	-1.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.2	-0.3	0.1	1.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.3	1.1	0.8	0.7
Birth weight of first child	0.2	0.5	0.9	-0.3	-0.9	0.6
Peak expiratory flow (PEF)	0.4	1.0	2.7	-0.4	1.7	-0.4
Pulse wave reflection index	0.3	0.3	0.6	0.6	0.8	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	0.4	0.3	-0.1
Loud music exposure frequency	0.8	0.9	2.2	-1.5	-0.6	-0.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.8	0.7	0.9	0.7
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.5	0.4	0.3	-1.2
Blood clot in the leg (DVT)	1.1	1.4	4.2	0.2	2.1	-0.3
Medication: Paracetamol	2.3	3.9	4.6	-2.1	-1.8	-2.0
Headache pain in last month	0.6	1.0	1.9	-0.8	-1.4	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	-1.0	-0.4	-0.4
Glaucoma (self-reported)	0.4	0.5	0.8	0.9	-0.1	0.8
Gout (self-reported)	0.3	0.4	1.0	-0.1	0.2	-1.0
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.1	-0.3	-0.4	0.2
Medication: Amlodipine	1.3	1.8	2.2	1.4	1.1	1.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.1	-1.1	0.1	0.0
Birth weight	0.5	1.1	2.3	1.5	0.9	0.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.6	-0.7	1.3	-1.1
High blood pressure (siblings)	0.1	0.2	0.2	-0.5	0.4	0.5
Forced vital capacity (FVC), Best measure	0.6	2.3	3.2	1.7	1.8	0.9
Body fat percentage	0.3	1.0	2.6	-1.6	0.0	0.7
Leg fat percentage (right)	0.2	0.6	1.0	-0.8	0.5	1.0
Arm fat-free mass (right)	0.3	1.5	2.2	-1.1	1.0	-1.5
Exposure to tobacco smoke outside home	1.5	2.0	5.0	-2.2	-0.2	-0.9
Comparative body size at age 10	1.2	3.4	5.9	2.0	-0.3	2.4
Number of full brothers	2.6	3.3	5.7	2.4	2.0	0.1
Worry too long after embarrassment	0.6	1.0	1.3	1.1	1.1	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.5	0.2	1.2	-0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.6	-0.8	0.4	-0.3
Number of children fathered	0.2	0.2	0.3	-0.3	0.5	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	1.5	0.6	1.2	0.9
Age at first live birth	1.3	2.4	3.3	-0.7	-1.8	-1.8
Pulse wave peak to peak time	1.2	1.4	2.6	-0.5	-1.1	1.6
Health satisfaction	0.5	0.6	1.3	0.3	1.1	0.6
Shortness of breath walking on level ground	0.6	0.7	1.1	0.6	1.0	0.9
Qualifications: College or University degree	0.2	0.5	1.3	1.1	0.4	-0.2
Eye problems/disorders: None of the above	1.5	1.8	3.9	0.4	-1.1	2.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	-0.6	0.2	0.6
Emphysema/chronic bronchitis	0.0	0.0	0.0	-0.2	0.1	-0.1
Medication for pain relief, constipation, heartburn	0.5	0.9	1.9	1.4	0.9	0.3
Neck or shoulder pain in last month	0.9	1.3	2.8	-0.9	-1.7	-0.3
Medication: Blood pressure	0.1	0.2	0.5	0.3	0.7	-0.3
Angina (self-reported)	2.2	2.9	8.0	0.8	2.8	0.2
Migraine (self-reported)	1.1	1.4	3.5	1.9	0.6	0.5
Medication: Ibuprofen	0.3	0.4	0.9	-0.3	-1.0	0.4
Medication: Allopurinol	0.2	0.2	0.6	0.8	0.4	-0.0
Medication: Omeprazole	0.7	0.9	2.3	0.4	1.5	0.3
Medication: Seretide 50 evohaler	1.4	1.7	2.3	-1.5	-0.6	-1.5
Mean time to correctly identify matches	1.0	1.9	3.1	-0.4	-1.8	1.5
Heart disease (mother)	1.5	1.9	3.8	0.1	-2.0	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	-0.8	-0.6	-0.1
Whole body fat mass	0.2	0.9	2.6	-1.6	0.4	0.2
Leg fat mass (right)	0.2	0.7	1.4	-1.2	0.7	0.3
Arm predicted mass (right)	0.3	1.3	2.0	-1.1	0.9	-1.4
Pulse rate, automated reading	0.8	2.7	6.8	1.1	2.6	0.4
Alcohol intake frequency.	0.1	0.3	0.5	-0.3	-0.7	0.4
Comparative height size at age 10	0.8	4.5	10.9	-3.3	-0.9	-1.4
Number of full sisters	0.8	0.9	1.7	0.7	1.3	-0.8
Suffer from ‘nerves’	1.1	1.8	3.1	1.4	1.8	-0.5
Overall health rating	0.0	0.1	0.1	-0.3	-0.1	0.4
Chest pain or discomfort	0.5	0.7	1.6	1.3	-0.7	-0.2
Had major operations	1.4	1.6	2.1	-1.4	-1.4	-1.0
Age at last live birth	0.2	0.3	0.4	-0.6	-0.7	-0.3
Family relationship satisfaction	0.9	1.1	2.6	-1.6	-0.8	-0.1
Leg pain on walking	0.3	0.4	0.7	0.3	0.7	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.1	1.5	0.3	1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.9	0.5	0.9	-0.4
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.9	0.1	1.4	0.7
Medication: Aspirin	0.8	1.1	2.7	0.7	1.6	0.3
Supplements: Vitamin C	0.7	0.8	1.6	1.3	-0.3	0.8
Knee pain experienced in last month	0.3	0.4	0.8	0.1	0.7	0.9
Hypertension (Self-reported)	0.2	0.6	0.9	-0.6	0.9	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.5	1.9	-0.3	-0.5
Illnesses of father: Heart disease	0.4	0.5	1.1	0.5	1.1	0.3
Illnesses of siblings: Diabetes	0.4	0.5	0.8	-0.7	-0.5	-0.9
Smoking status: Previous	0.5	0.8	2.1	-0.1	1.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.7	-1.2	-0.2	-1.3
Whole body fat-free mass	0.2	1.1	1.6	-1.2	0.6	-1.1
Leg fat-free mass (right)	0.1	0.8	1.1	-0.9	0.8	-1.0
Arm fat percentage (left)	0.2	0.7	1.1	-1.1	0.6	0.7
Average weekly red wine intake	0.1	0.2	0.2	-0.2	0.4	-0.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.9	-1.4	-0.1	-1.3
Mood swings	0.5	0.9	1.7	0.7	0.7	-1.3
Loneliness, isolation	0.7	1.0	1.4	1.0	1.2	0.8
Long-standing illness, disability or infirmity	0.4	0.6	1.1	0.4	0.8	-1.0
Ever had bowel cancer screening	0.6	0.7	1.5	0.4	1.2	-0.6
Diabetes diagnosed by doctor	0.6	0.9	2.6	0.1	1.6	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.3	1.1	-0.2	0.1
Friendships satisfaction	0.8	1.0	1.5	-1.2	-0.8	-0.9
Qualifications: nursing, teaching	0.6	1.0	1.6	-1.1	-0.4	-1.3
Commuting to job workplace: Walk	1.6	1.8	4.0	-1.0	-2.0	0.5
Eye problems/disorders: Cataract	3.0	3.4	6.1	-2.0	0.2	-2.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.6	0.3	-0.8
Medication for cholesterol	0.3	0.4	0.6	0.8	-0.7	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.7	3.6	1.1	1.9	-0.4
Back pain experienced in last month	0.2	0.2	0.7	-0.0	0.1	-0.8
Mineral and other dietary supplements	0.2	0.3	0.7	-0.9	0.3	-0.1
Breast cancer (self-reported)	1.6	1.9	2.7	-0.5	-1.6	-1.6
Asthma (self-reported)	0.0	0.1	0.2	-0.2	0.0	-0.5
Osteoporosis (self-reported)	0.5	0.6	0.8	-0.2	-0.9	-0.9
Osteoarthritis (self-reported)	1.2	1.6	3.7	-0.9	1.9	-0.4
Medication: Aspirin	0.7	1.0	2.3	0.7	1.5	0.4
Medication: Gliclazide	0.3	0.3	0.7	-0.4	-0.1	-0.8
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	0.2	0.1	-0.1
Smoking status: Current	0.1	0.2	0.4	0.3	0.4	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.2	1.0	1.1	0.6
Whole body water mass	0.2	1.0	1.4	-1.2	0.7	-1.1
Leg predicted mass (right)	0.1	0.8	1.0	-0.9	0.7	-1.0
Arm fat mass (left)	0.2	0.8	2.0	-1.4	0.6	0.1
Number of self-reported non-cancer illnesses	0.4	0.7	2.0	-0.3	1.4	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	1.5	-1.2	-0.8	0.2
Miserableness	0.2	0.3	0.4	0.6	0.6	0.4
Guilty feelings	0.2	0.3	0.7	-0.8	-0.3	0.1
Wears glasses or contact lenses	0.0	0.0	0.0	0.0	-0.1	-0.0
Ever taken oral contraceptive pill	0.9	1.0	2.8	0.4	1.7	-0.1
Hearing aid user	0.4	0.4	0.5	0.7	-0.7	0.6
Mother’s age at death	2.1	2.6	3.6	1.7	1.3	1.9
Financial situation satisfaction	0.4	0.4	1.1	-0.4	-1.1	-0.0
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.3	1.1	-0.1	0.2
Commuting to job workplace: Public transport	1.0	1.2	2.2	0.9	1.5	0.9
Eye problems/disorders: Glaucoma	0.3	0.3	0.5	0.6	0.7	0.3
Medication: Blood pressure	0.5	0.9	1.8	-0.7	1.3	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	-0.1	0.5	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.5	1.6	0.5	0.6
High cholesterol (Self-reported)	1.6	2.8	7.4	2.7	0.2	1.1
Medication: Bendroflumethiazide	0.4	0.7	1.4	-1.2	0.7	-0.1
Medication: Paracetamol	3.4	5.2	5.8	-2.4	-2.3	-2.1
Medication: Lisinopril	2.0	2.6	7.6	-0.4	-0.2	-2.8
Medication: Atorvastatin	1.3	1.6	3.2	0.8	1.0	1.8
Illnesses of father: High blood pressure	0.6	0.7	2.1	-0.2	-1.4	-0.2
Alcohol drinker status: Never	0.8	1.0	2.9	1.7	0.1	-0.0
Ever smoked	0.5	0.8	1.4	-0.5	1.2	-0.8
Basal metabolic rate	0.2	1.1	1.8	-1.4	0.7	-0.9
Leg fat percentage (left)	0.1	0.4	0.6	-0.6	0.5	0.8
Arm fat-free mass (left)	0.2	1.0	1.8	-1.4	0.5	-0.9
Number of operations (self-reported)	4.1	6.0	12.7	-3.6	-0.8	-2.2
Average weekly beer plus cider intake	0.6	0.9	1.5	0.1	1.2	1.1
Irritability	0.7	1.2	1.7	-1.1	-0.9	-1.3
Risk taking	0.3	0.4	0.9	-0.6	-0.9	0.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	0.8	0.9	0.8	0.8
Fractured/broken bones in last 5 years	0.3	0.4	0.7	0.8	0.8	0.0
Age started oral contraceptive pill	0.3	0.3	0.6	0.1	0.8	-0.6
Diastolic blood pressure, automated reading	1.5	4.5	7.4	2.3	2.7	0.9
Ever depressed for a whole week	0.9	1.2	2.8	-1.7	-0.3	0.8
Unable to work because of sickness or disability	0.8	1.1	2.8	-1.7	0.4	0.6
Commuting to job workplace: Cycle	0.5	0.5	0.8	-0.9	-0.9	-0.4
Myopia	1.4	2.0	4.7	-0.3	-2.2	1.1
Vascular/heart problems diagnosed by doctor	0.5	1.2	2.8	-0.1	-1.7	1.0
Cholesterol lowering medication	3.5	5.2	7.8	2.8	2.5	1.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	1.9	0.8	1.4	1.2
Pain experienced in last month	0.5	0.8	1.6	1.3	0.5	0.6
Supplements: Calcium	0.6	0.7	1.4	0.8	1.2	0.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	-0.5	-1.3	0.5
Heart attack/myocardial infarction (self-reported)	3.0	3.8	7.8	1.6	2.8	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.1	0.1	1.8	-0.1
Heart disease (siblings)	1.2	1.5	3.4	1.1	1.8	-0.3
Alcohol drinker status: Previous	1.1	1.2	2.0	-1.2	-1.4	-0.4
Pack years of smoking	0.1	0.1	0.2	-0.3	0.3	0.5
Impedance of whole body	0.3	1.4	2.1	-1.4	-1.3	-0.8
Leg fat mass (left)	0.1	0.5	0.9	-0.9	0.8	0.3
Arm predicted mass (left)	0.2	1.2	2.4	-1.6	0.3	-1.1