Hub : Genes

MZT1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1650 0.0580 2.2e-03 -0.003 NA 0.001 NA 0.000 5.1e-01 NA 0.29000 NA 0.31000
2 GTEx Muscle Skeletal 0.0768 0.0305 3.5e-03 0.058 NA 0.028 NA 0.037 2.3e-06 NA 0.00076 NA 0.00014
3 METSIM Adipose 0.0802 0.0235 1.8e-05 0.003 0.025 0.010 0.005 0.007 9.6e-02 9e-05 0.01100 0.049 0.02800

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.7 1.7 0.3 0.5 1.3
Bipolar Disorder or Schizophrenia 0.6 1.4 2.9 -1.7 -1.1 -0.3
Depressed Affect (Nagel 2018) 0.4 0.8 2.1 0.6 1.5 -0.2
Depression (Nagel 2018) 0.1 0.1 0.2 0.4 0.1 -0.4
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.0 1.4 0.6 1.0
Neuroticism (Nagel 2018) 0.5 1.1 2.3 -0.0 1.5 -1.0
Schizophrenia (2018) 1.6 3.3 5.4 -2.3 -1.8 -1.1
Schizophrenia vs Biploar Disorder 0.7 0.9 1.8 -1.3 -0.7 -0.8
Worry (Nagel 2018) 0.5 1.1 2.5 -0.2 1.6 -0.8
Alzheimer’s Disease (in mother) 1.5 1.7 4.4 -2.1 -0.8 0.4
Alzheimer’s Disease (in father) 3.8 4.1 6.2 -2.5 -2.2 -1.3
Alzheimer’s Disease (including proxy) 3.6 5.2 9.7 -3.1 -2.1 -1.1
Crohns Disease (2017) 3.0 6.5 10.9 -3.3 -2.2 -1.9
Irritable Bowel Disease (IBD) 1.4 3.4 5.3 -2.3 -1.3 -1.8
Ulcerative Colitis (UC) 1.0 1.8 3.4 -1.4 -0.1 -1.8
Major Depression (MDD) 1.0 1.2 2.8 -0.7 -1.7 -0.6
Reaction Time 0.5 0.9 2.4 0.3 -0.4 1.5
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.8 1.7 0.1 0.5
Breast Cancer 0.5 1.3 3.4 -0.3 -1.9 -0.6
Ovarian Cancer 0.4 0.6 0.9 0.2 -0.9 -0.9
Prostate Cancer 6.0 8.5 12.0 3.0 3.5 2.2
Age at First Birth 0.9 1.3 3.9 -0.3 -2.0 0.3
Bipolar Disorder (2011) 1.9 1.8 2.0 -1.4 -1.4 -1.3
Body Mass Index (BMI) (2010) 0.2 0.2 0.4 0.7 0.3 0.3
Coronary Artery Disease (CAD) 0.8 0.9 1.0 1.0 1.0 0.9
Crohns Disease (2012) 3.0 4.9 7.9 -2.3 -1.3 -2.8
Mean Putamen Volume 3.1 3.5 6.7 1.9 2.6 0.2
Fasting Glucose 1.6 1.9 4.0 -2.0 0.1 -1.3
HbA1C 0.0 0.1 0.1 -0.3 -0.2 -0.2
HDL Cholesterol 0.3 0.5 1.3 1.1 0.4 0.3
LDL Cholesterol 0.4 0.6 1.0 0.5 1.0 -0.8
Lupus 0.5 0.7 1.4 1.2 0.7 0.5
Neuroticism (2016) 0.1 0.1 0.2 0.5 0.1 0.1
Primary Biliary Cirrhosis 1.3 1.9 4.1 0.7 -1.1 2.0
Rheumatoid Arthritis 4.6 6.4 15.3 1.9 3.9 -0.0
Schizophrenia (2014) 1.9 4.3 8.7 -3.0 -1.6 -1.2
Triglycerides 0.7 1.1 1.4 -0.8 1.2 -1.2
Type 2 Diabetes (T2D) (2012) 0.1 0.2 0.3 -0.4 -0.6 0.1
Ulcerative Colitis 0.6 0.8 2.0 -0.7 -0.2 -1.4
Blood Eosinophil Count 1.6 12.0 21.4 -2.9 -4.6 -2.5
Blood Platelet Count 0.6 7.3 14.0 -2.5 -1.3 -3.7
Blood Red Count 0.1 1.4 3.3 0.1 -0.9 1.8
Blood White Count 0.0 0.3 0.9 0.9 -0.3 0.3
Heel T-Score 0.1 0.7 1.3 1.1 -0.4 0.7
BMI 0.1 0.4 0.9 -0.9 0.3 0.5
Height 0.5 9.6 14.3 -3.7 1.1 -3.8
Waist Hip Ratio (WHR) 0.5 2.3 4.8 -1.4 0.0 -2.2
Systolic Blood Pressure 0.2 0.8 2.4 0.1 1.5 0.3
Smoking Status 0.3 0.7 2.0 0.2 1.4 -0.1
Allergy or Eczema 2.5 6.7 7.9 -2.4 -2.5 -2.8
Cardiovascular Disease 0.1 0.2 0.4 0.6 0.5 0.3
Hypothyroidism (self reported) 0.2 0.5 1.3 0.2 -0.4 1.1
Respiratory disease 2.0 4.3 9.0 -1.9 -0.5 -3.0
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.7 -0.7 0.2 -0.8
Lung FEV1/FVC ratio 1.2 5.9 6.8 -2.6 2.6 -2.1
Lung FVC 2.4 12.1 26.9 5.2 2.0 2.4
Neuroticism 0.4 1.0 2.1 -1.5 0.1 -0.9
Chronotype (morning person) 4.5 10.4 22.4 -3.0 0.2 -4.7
Hair Pigment 0.1 3.2 3.7 -1.9 -1.5 1.9
Tanning 0.0 0.1 0.2 0.5 0.1 -0.1
Hand grip strength (left) 0.6 1.5 2.9 1.1 1.7 -0.5
Number of treatments/medications taken 0.0 0.0 0.1 0.2 -0.0 -0.3
Average weekly spirits intake 0.2 0.3 0.6 0.3 0.3 -0.8
Sensitivity / hurt feelings 1.2 2.0 3.1 0.2 1.7 -1.8
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.3 0.2 0.1 1.1
Hearing difficulty/problems: Yes 1.1 1.7 2.5 1.1 1.6 1.1
Relative age of first facial hair 0.7 1.4 4.0 0.3 0.4 2.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.2 1.1 0.2 0.8
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 -0.5 0.2 0.3
Ever had hysterectomy (womb removed) 0.7 0.8 1.9 -0.6 1.4 0.4
Systolic blood pressure, automated reading 0.5 1.3 2.2 0.2 1.5 1.3
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.7 -0.5 -0.3 -1.6
Angina 2.6 3.4 9.1 0.9 3.0 0.6
Medication for hormone replacement therapy 1.4 1.6 2.7 -1.7 -1.4 0.4
Vitamin and mineral supplements 0.8 1.1 3.1 0.1 0.4 1.8
Supplements: Zinc 0.1 0.1 0.2 0.2 0.2 0.4
Medication: Co-codamol 2.0 2.3 3.9 -1.6 0.7 -2.0
Medication: Metformin 0.2 0.2 0.4 -0.4 0.6 -0.3
Diabetes (father) 1.0 1.2 2.1 -1.4 0.4 -1.2
Diabetes (mother) 0.6 0.7 0.9 0.7 0.9 -1.0
Severe depression (siblings) 0.4 0.4 0.9 -1.0 0.4 -0.4
Pack years adult smoking proportion 0.2 0.3 0.6 -0.3 0.5 0.8
Impedance of leg (right) 0.2 0.8 1.3 -1.1 -1.0 -0.4
Leg fat-free mass (left) 0.2 0.9 1.4 -1.2 0.7 -0.9
Trunk fat percentage 0.3 1.0 2.7 -1.6 0.1 0.6
Hand grip strength (right) 0.3 0.7 1.6 0.7 1.3 -0.2
Townsend deprivation index at recruitment 1.4 2.0 4.1 1.3 0.6 2.0
Current tobacco smoking 0.1 0.2 0.4 0.3 0.6 -0.1
Average weekly fortified wine intake 0.2 0.2 0.6 -0.2 0.8 -0.2
Maternal smoking around birth 0.4 0.5 1.1 -0.1 1.1 -0.7
Fed-up feelings 0.5 0.9 1.9 -0.7 -0.5 -1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.5 -0.7 0.0 -0.0
Relative age voice broke 1.0 1.5 4.3 -0.1 0.5 2.1
Taking other prescription medications 1.4 2.2 5.4 1.0 2.3 -0.4
Age when periods started (menarche) 0.2 0.6 1.5 1.2 -0.2 -0.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.6 -0.8 -0.1 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.0 3.6 1.5 0.2 1.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.6 -0.7 0.2
Qualifications: CSEs or equivalent 0.4 0.6 1.6 -0.2 0.4 -1.3
Serious illness, injury or assault to yourself 0.3 0.4 0.8 -0.3 -0.9 -0.5
High blood pressure 0.2 0.6 0.7 -0.7 0.8 -0.8
Hayfever, allergic rhinitis or eczema 1.6 3.5 5.4 -1.4 -2.3 -1.8
Multivitamins +/- minerals 1.3 1.6 3.4 -0.5 -1.1 -1.8
Stomach or abdominal pain in last month 0.6 0.7 1.3 -0.4 0.8 -1.1
Supplements: Glucosamine 0.4 0.5 1.1 -0.0 -0.6 -1.1
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 1.8 -0.9 0.2 -1.4
Medication: Atenolol 0.9 1.2 1.7 0.9 1.3 1.1
Medication: Levothyroxine sodium 0.0 0.0 0.1 -0.0 0.3 -0.2
Sitting height 0.8 5.6 8.4 -2.9 -1.8 -2.3
Chronic bronchitis/emphysema (father) 2.6 3.0 3.8 2.0 1.3 1.8
High blood pressure (mother) 1.2 1.7 4.5 -2.1 -0.4 0.8
Body mass index (BMI) 0.2 0.8 1.2 -0.3 1.1 1.1
Impedance of leg (left) 0.1 0.5 0.8 -0.7 -0.9 -0.5
Leg predicted mass (left) 0.2 0.9 1.3 -1.1 0.8 -0.8
Trunk fat mass 0.2 1.0 2.8 -1.7 0.3 0.1
Waist circumference 0.2 0.9 1.5 -1.2 1.0 -0.5
Number of incorrect matches in round 0.4 0.6 1.1 -1.0 0.8 -0.2
Past tobacco smoking 0.6 1.1 3.1 0.4 -1.8 0.4
Alcohol usually taken with meals 1.0 1.7 3.0 -1.7 -1.0 -1.0
Nervous feelings 1.4 2.6 6.6 1.1 2.6 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.9 0.2 1.0 0.0
Hearing difficulty/problems with background noise 2.0 3.2 6.6 1.3 2.6 1.2
Hair/balding pattern: Pattern 2 5.3 6.7 13.6 -3.7 -0.3 -2.5
Had menopause 0.2 0.3 0.7 -0.4 0.3 0.8
Had other major operations 0.3 0.4 0.9 -1.0 0.2 0.3
Forced vital capacity (FVC) 0.6 2.2 3.4 1.7 1.9 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.0 0.8 -0.1 1.7
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.3 -1.1 0.1 0.8
Qualifications: None of the above 0.4 0.8 1.7 -0.9 0.1 -1.3
Financial difficulties in last 2 years 2.1 2.8 6.4 -1.4 -2.5 0.2
Mouth/teeth dental problems 0.1 0.2 0.4 0.6 -0.5 0.2
Heart attack 3.2 4.1 8.2 1.8 2.9 -1.0
Allergy 1.0 2.2 4.0 1.5 0.5 2.0
Pain all over the body in last month 2.2 2.4 6.2 0.9 2.5 0.0
Diabetes (self-reported) 0.3 0.5 1.5 -0.2 1.2 0.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 -0.2 -0.3 0.4
Medication: Ramipril 0.9 1.2 3.0 0.7 1.7 -0.1
Medication: Simvastatin 1.4 2.0 4.4 2.1 1.1 -0.7
Fluid intelligence score 0.2 0.4 1.0 0.2 -1.0 0.1
Illnesses of siblings 0.2 0.3 0.6 0.0 -0.6 -0.8
Neuroticism score 0.2 0.5 1.0 0.0 1.0 -0.7
Weight 0.2 0.9 1.5 -1.2 1.0 -0.1
Impedance of arm (right) 0.2 1.1 1.8 -1.2 -1.3 -0.4
Arm fat percentage (right) 0.2 0.9 1.5 -1.2 0.1 1.1
Trunk fat-free mass 0.2 1.2 1.7 -1.2 0.6 -1.3
Hip circumference 0.2 0.7 2.0 -1.4 -0.0 0.1
Time employed in main current job 0.8 0.9 2.2 0.4 1.5 0.5
Alcohol intake versus 10 years previously 0.8 1.2 2.1 1.0 -0.6 1.4
Father’s age at death 1.8 2.4 6.1 -2.5 -0.8 -0.7
Worrier / anxious feelings 0.8 1.6 3.3 0.4 1.8 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.7 0.3 0.9 0.7
Falls in the last year 0.5 0.6 1.9 -0.0 1.4 0.3
Hair/balding pattern: Pattern 3 1.8 2.7 6.0 2.4 -0.4 1.4
Number of live births 0.2 0.3 0.5 -0.6 0.7 0.3
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 5.4 0.9 2.3 0.2
Pulse rate 0.7 1.2 2.5 0.5 1.6 -1.0
Happiness 1.1 1.3 3.7 -1.9 -0.5 -0.3
Noisy workplace 0.6 0.7 1.3 0.8 0.5 1.1
Qualifications: A levels/AS levels or equivalent 0.9 2.1 3.3 1.8 1.6 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 1.1 -0.6 1.0 -0.7
Mouth/teeth dental problems: Dentures 0.7 1.2 1.8 0.3 1.3 1.4
Asthma 0.1 0.2 0.4 0.2 0.6 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.8 -0.4 -0.9 0.6
Medication: Cholesterol lowering 0.8 1.3 2.1 1.4 0.9 1.0
Depression (self-reported) 1.2 1.4 2.2 1.3 1.5 0.6
Medication: Lansoprazole 0.2 0.2 0.4 -0.6 0.3 -0.5
Prospective memory result 0.1 0.1 0.2 -0.2 0.3 0.5
Lung cancer (father) 1.5 1.7 3.9 0.9 0.8 2.0
Illnesses of mother 0.6 0.8 2.1 1.5 -0.5 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 5.0 0.8 2.2 0.4
Pulse wave Arterial Stiffness index 1.2 1.4 2.9 0.3 1.1 -1.7
Impedance of arm (left) 0.3 1.3 1.8 -1.4 -1.1 -0.9
Arm fat mass (right) 0.2 0.8 1.8 -1.3 0.6 0.5
Trunk predicted mass 0.2 1.3 1.9 -1.4 0.5 -1.3
Standing height 0.5 4.8 7.5 -2.6 -0.2 -2.7
Length of working week for main job 0.3 0.3 0.7 -0.2 -0.8 -0.5
Exposure to tobacco smoke at home 0.6 0.7 1.5 0.6 1.2 0.5
Breastfed as a baby 0.6 0.8 1.1 0.9 0.6 1.1
Tense / ‘highly strung’ 0.6 1.0 1.6 -1.0 -1.3 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 2.2 -0.3 0.1 1.5
Hair/balding pattern: Pattern 4 0.3 0.8 1.3 1.1 0.8 0.7
Birth weight of first child 0.2 0.5 0.9 -0.3 -0.9 0.6
Peak expiratory flow (PEF) 0.4 1.0 2.7 -0.4 1.7 -0.4
Pulse wave reflection index 0.3 0.3 0.6 0.6 0.8 0.3
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 0.4 0.3 -0.1
Loud music exposure frequency 0.8 0.9 2.2 -1.5 -0.6 -0.3
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 0.8 0.7 0.9 0.7
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.5 0.4 0.3 -1.2
Blood clot in the leg (DVT) 1.1 1.4 4.2 0.2 2.1 -0.3
Medication: Paracetamol 2.3 3.9 4.6 -2.1 -1.8 -2.0
Headache pain in last month 0.6 1.0 1.9 -0.8 -1.4 -0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.4 0.9 -1.0 -0.4 -0.4
Glaucoma (self-reported) 0.4 0.5 0.8 0.9 -0.1 0.8
Gout (self-reported) 0.3 0.4 1.0 -0.1 0.2 -1.0
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.1 -0.3 -0.4 0.2
Medication: Amlodipine 1.3 1.8 2.2 1.4 1.1 1.5
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.1 -1.1 0.1 0.0
Birth weight 0.5 1.1 2.3 1.5 0.9 0.5
Chronic bronchitis/emphysema (mother) 1.0 1.1 1.6 -0.7 1.3 -1.1
High blood pressure (siblings) 0.1 0.2 0.2 -0.5 0.4 0.5
Forced vital capacity (FVC), Best measure 0.6 2.3 3.2 1.7 1.8 0.9
Body fat percentage 0.3 1.0 2.6 -1.6 0.0 0.7
Leg fat percentage (right) 0.2 0.6 1.0 -0.8 0.5 1.0
Arm fat-free mass (right) 0.3 1.5 2.2 -1.1 1.0 -1.5
Exposure to tobacco smoke outside home 1.5 2.0 5.0 -2.2 -0.2 -0.9
Comparative body size at age 10 1.2 3.4 5.9 2.0 -0.3 2.4
Number of full brothers 2.6 3.3 5.7 2.4 2.0 0.1
Worry too long after embarrassment 0.6 1.0 1.3 1.1 1.1 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.5 0.2 1.2 -0.1
Wheeze or whistling in the chest in last year 0.2 0.3 0.6 -0.8 0.4 -0.3
Number of children fathered 0.2 0.2 0.3 -0.3 0.5 0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.9 1.5 0.6 1.2 0.9
Age at first live birth 1.3 2.4 3.3 -0.7 -1.8 -1.8
Pulse wave peak to peak time 1.2 1.4 2.6 -0.5 -1.1 1.6
Health satisfaction 0.5 0.6 1.3 0.3 1.1 0.6
Shortness of breath walking on level ground 0.6 0.7 1.1 0.6 1.0 0.9
Qualifications: College or University degree 0.2 0.5 1.3 1.1 0.4 -0.2
Eye problems/disorders: None of the above 1.5 1.8 3.9 0.4 -1.1 2.0
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.3 -0.6 0.2 0.6
Emphysema/chronic bronchitis 0.0 0.0 0.0 -0.2 0.1 -0.1
Medication for pain relief, constipation, heartburn 0.5 0.9 1.9 1.4 0.9 0.3
Neck or shoulder pain in last month 0.9 1.3 2.8 -0.9 -1.7 -0.3
Medication: Blood pressure 0.1 0.2 0.5 0.3 0.7 -0.3
Angina (self-reported) 2.2 2.9 8.0 0.8 2.8 0.2
Migraine (self-reported) 1.1 1.4 3.5 1.9 0.6 0.5
Medication: Ibuprofen 0.3 0.4 0.9 -0.3 -1.0 0.4
Medication: Allopurinol 0.2 0.2 0.6 0.8 0.4 -0.0
Medication: Omeprazole 0.7 0.9 2.3 0.4 1.5 0.3
Medication: Seretide 50 evohaler 1.4 1.7 2.3 -1.5 -0.6 -1.5
Mean time to correctly identify matches 1.0 1.9 3.1 -0.4 -1.8 1.5
Heart disease (mother) 1.5 1.9 3.8 0.1 -2.0 -1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.7 -0.8 -0.6 -0.1
Whole body fat mass 0.2 0.9 2.6 -1.6 0.4 0.2
Leg fat mass (right) 0.2 0.7 1.4 -1.2 0.7 0.3
Arm predicted mass (right) 0.3 1.3 2.0 -1.1 0.9 -1.4
Pulse rate, automated reading 0.8 2.7 6.8 1.1 2.6 0.4
Alcohol intake frequency. 0.1 0.3 0.5 -0.3 -0.7 0.4
Comparative height size at age 10 0.8 4.5 10.9 -3.3 -0.9 -1.4
Number of full sisters 0.8 0.9 1.7 0.7 1.3 -0.8
Suffer from ‘nerves’ 1.1 1.8 3.1 1.4 1.8 -0.5
Overall health rating 0.0 0.1 0.1 -0.3 -0.1 0.4
Chest pain or discomfort 0.5 0.7 1.6 1.3 -0.7 -0.2
Had major operations 1.4 1.6 2.1 -1.4 -1.4 -1.0
Age at last live birth 0.2 0.3 0.4 -0.6 -0.7 -0.3
Family relationship satisfaction 0.9 1.1 2.6 -1.6 -0.8 -0.1
Leg pain on walking 0.3 0.4 0.7 0.3 0.7 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 2.1 1.5 0.3 1.1
Commuting to job workplace: Car/motor vehicle 0.4 0.4 0.9 0.5 0.9 -0.4
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.9 0.1 1.4 0.7
Medication: Aspirin 0.8 1.1 2.7 0.7 1.6 0.3
Supplements: Vitamin C 0.7 0.8 1.6 1.3 -0.3 0.8
Knee pain experienced in last month 0.3 0.4 0.8 0.1 0.7 0.9
Hypertension (Self-reported) 0.2 0.6 0.9 -0.6 0.9 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.5 1.9 -0.3 -0.5
Illnesses of father: Heart disease 0.4 0.5 1.1 0.5 1.1 0.3
Illnesses of siblings: Diabetes 0.4 0.5 0.8 -0.7 -0.5 -0.9
Smoking status: Previous 0.5 0.8 2.1 -0.1 1.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.7 -1.2 -0.2 -1.3
Whole body fat-free mass 0.2 1.1 1.6 -1.2 0.6 -1.1
Leg fat-free mass (right) 0.1 0.8 1.1 -0.9 0.8 -1.0
Arm fat percentage (left) 0.2 0.7 1.1 -1.1 0.6 0.7
Average weekly red wine intake 0.1 0.2 0.2 -0.2 0.4 -0.5
Handedness (chirality/laterality): Left-handed 1.0 1.2 1.9 -1.4 -0.1 -1.3
Mood swings 0.5 0.9 1.7 0.7 0.7 -1.3
Loneliness, isolation 0.7 1.0 1.4 1.0 1.2 0.8
Long-standing illness, disability or infirmity 0.4 0.6 1.1 0.4 0.8 -1.0
Ever had bowel cancer screening 0.6 0.7 1.5 0.4 1.2 -0.6
Diabetes diagnosed by doctor 0.6 0.9 2.6 0.1 1.6 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.3 1.1 -0.2 0.1
Friendships satisfaction 0.8 1.0 1.5 -1.2 -0.8 -0.9
Qualifications: nursing, teaching 0.6 1.0 1.6 -1.1 -0.4 -1.3
Commuting to job workplace: Walk 1.6 1.8 4.0 -1.0 -2.0 0.5
Eye problems/disorders: Cataract 3.0 3.4 6.1 -2.0 0.2 -2.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.6 -0.6 0.3 -0.8
Medication for cholesterol 0.3 0.4 0.6 0.8 -0.7 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.7 3.6 1.1 1.9 -0.4
Back pain experienced in last month 0.2 0.2 0.7 -0.0 0.1 -0.8
Mineral and other dietary supplements 0.2 0.3 0.7 -0.9 0.3 -0.1
Breast cancer (self-reported) 1.6 1.9 2.7 -0.5 -1.6 -1.6
Asthma (self-reported) 0.0 0.1 0.2 -0.2 0.0 -0.5
Osteoporosis (self-reported) 0.5 0.6 0.8 -0.2 -0.9 -0.9
Osteoarthritis (self-reported) 1.2 1.6 3.7 -0.9 1.9 -0.4
Medication: Aspirin 0.7 1.0 2.3 0.7 1.5 0.4
Medication: Gliclazide 0.3 0.3 0.7 -0.4 -0.1 -0.8
Illnesses of father: None of the above (group 1) 0.0 0.0 0.0 0.2 0.1 -0.1
Smoking status: Current 0.1 0.2 0.4 0.3 0.4 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.2 1.0 1.1 0.6
Whole body water mass 0.2 1.0 1.4 -1.2 0.7 -1.1
Leg predicted mass (right) 0.1 0.8 1.0 -0.9 0.7 -1.0
Arm fat mass (left) 0.2 0.8 2.0 -1.4 0.6 0.1
Number of self-reported non-cancer illnesses 0.4 0.7 2.0 -0.3 1.4 -0.4
Average weekly champagne plus white wine intake 0.5 0.7 1.5 -1.2 -0.8 0.2
Miserableness 0.2 0.3 0.4 0.6 0.6 0.4
Guilty feelings 0.2 0.3 0.7 -0.8 -0.3 0.1
Wears glasses or contact lenses 0.0 0.0 0.0 0.0 -0.1 -0.0
Ever taken oral contraceptive pill 0.9 1.0 2.8 0.4 1.7 -0.1
Hearing aid user 0.4 0.4 0.5 0.7 -0.7 0.6
Mother’s age at death 2.1 2.6 3.6 1.7 1.3 1.9
Financial situation satisfaction 0.4 0.4 1.1 -0.4 -1.1 -0.0
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.3 1.1 -0.1 0.2
Commuting to job workplace: Public transport 1.0 1.2 2.2 0.9 1.5 0.9
Eye problems/disorders: Glaucoma 0.3 0.3 0.5 0.6 0.7 0.3
Medication: Blood pressure 0.5 0.9 1.8 -0.7 1.3 -0.8
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 -0.1 0.5 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.5 1.6 0.5 0.6
High cholesterol (Self-reported) 1.6 2.8 7.4 2.7 0.2 1.1
Medication: Bendroflumethiazide 0.4 0.7 1.4 -1.2 0.7 -0.1
Medication: Paracetamol 3.4 5.2 5.8 -2.4 -2.3 -2.1
Medication: Lisinopril 2.0 2.6 7.6 -0.4 -0.2 -2.8
Medication: Atorvastatin 1.3 1.6 3.2 0.8 1.0 1.8
Illnesses of father: High blood pressure 0.6 0.7 2.1 -0.2 -1.4 -0.2
Alcohol drinker status: Never 0.8 1.0 2.9 1.7 0.1 -0.0
Ever smoked 0.5 0.8 1.4 -0.5 1.2 -0.8
Basal metabolic rate 0.2 1.1 1.8 -1.4 0.7 -0.9
Leg fat percentage (left) 0.1 0.4 0.6 -0.6 0.5 0.8
Arm fat-free mass (left) 0.2 1.0 1.8 -1.4 0.5 -0.9
Number of operations (self-reported) 4.1 6.0 12.7 -3.6 -0.8 -2.2
Average weekly beer plus cider intake 0.6 0.9 1.5 0.1 1.2 1.1
Irritability 0.7 1.2 1.7 -1.1 -0.9 -1.3
Risk taking 0.3 0.4 0.9 -0.6 -0.9 0.1
Ever had prostate specific antigen (PSA) test 0.6 0.7 0.8 0.9 0.8 0.8
Fractured/broken bones in last 5 years 0.3 0.4 0.7 0.8 0.8 0.0
Age started oral contraceptive pill 0.3 0.3 0.6 0.1 0.8 -0.6
Diastolic blood pressure, automated reading 1.5 4.5 7.4 2.3 2.7 0.9
Ever depressed for a whole week 0.9 1.2 2.8 -1.7 -0.3 0.8
Unable to work because of sickness or disability 0.8 1.1 2.8 -1.7 0.4 0.6
Commuting to job workplace: Cycle 0.5 0.5 0.8 -0.9 -0.9 -0.4
Myopia 1.4 2.0 4.7 -0.3 -2.2 1.1
Vascular/heart problems diagnosed by doctor 0.5 1.2 2.8 -0.1 -1.7 1.0
Cholesterol lowering medication 3.5 5.2 7.8 2.8 2.5 1.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 1.9 0.8 1.4 1.2
Pain experienced in last month 0.5 0.8 1.6 1.3 0.5 0.6
Supplements: Calcium 0.6 0.7 1.4 0.8 1.2 0.0
Basal cell carcinoma (self-reported) 0.6 0.7 1.6 -0.5 -1.3 0.5
Heart attack/myocardial infarction (self-reported) 3.0 3.8 7.8 1.6 2.8 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 3.1 0.1 1.8 -0.1
Heart disease (siblings) 1.2 1.5 3.4 1.1 1.8 -0.3
Alcohol drinker status: Previous 1.1 1.2 2.0 -1.2 -1.4 -0.4
Pack years of smoking 0.1 0.1 0.2 -0.3 0.3 0.5
Impedance of whole body 0.3 1.4 2.1 -1.4 -1.3 -0.8
Leg fat mass (left) 0.1 0.5 0.9 -0.9 0.8 0.3
Arm predicted mass (left) 0.2 1.2 2.4 -1.6 0.3 -1.1