Hub : Genes

NACA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0524	0.0186	4.5e-06	0.050	0.036	0.038	0.043	0.044	5.6e-08	3.1e-06	2.2e-06	4.4e-07	3.1e-07
2	NTR	Blood	0.0119	0.0054	3.6e-03	0.009	0.006	0.004	0.006	0.007	4.7e-04	4.2e-03	2.0e-02	4.3e-03	2.4e-03
3	TCGA	Breast Invasive Carcinoma	0.0351	0.0221	4.9e-03	0.005	0.005	0.012	NA	0.012	3.3e-02	3.1e-02	1.3e-03	NA	1.6e-03
4	TCGA	Prostate Adenocarcinoma	0.0194	0.0124	3.0e-03	0.016	0.023	0.004	NA	0.016	6.8e-03	1.8e-03	1.1e-01	NA	7.3e-03
5	TCGA	Thyroid Carcinoma	0.1490	0.0680	8.0e-04	0.000	0.027	0.028	NA	-0.002	2.9e-01	9.9e-04	8.3e-04	NA	5.9e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	1.2	1.1	-0.9	0.0	1.1	1.1
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.5	0.1	0.0	-0.4	0.3
Depressed Affect (Nagel 2018)	4.7	10.0	16.1	3.1	-3.7	2.9	4.0	1.3
Depression (Nagel 2018)	3.5	5.3	7.2	2.3	-2.7	2.3	2.7	1.3
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.0	-1.0	1.4	-0.1	-0.9	1.3
Neuroticism (Nagel 2018)	1.2	2.8	4.3	1.5	-1.9	1.8	2.1	0.7
Schizophrenia (2018)	0.5	1.1	2.3	-1.5	0.9	0.0	-1.4	-0.5
Schizophrenia vs Biploar Disorder	0.6	0.8	2.5	-1.1	0.2	0.0	-0.5	-1.6
Worry (Nagel 2018)	0.2	0.5	1.1	-0.6	0.4	0.6	-0.5	1.1
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.6	0.3	0.7	-0.6	0.2
Alzheimer’s Disease (in father)	0.3	0.3	0.8	0.9	-0.5	0.3	0.6	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.8	0.0	-0.0	0.9	-0.1	0.4
Crohns Disease (2017)	0.8	1.9	3.5	1.5	-1.0	1.2	1.9	1.2
Irritable Bowel Disease (IBD)	0.5	1.1	3.0	0.0	0.3	1.7	0.6	1.5
Ulcerative Colitis (UC)	0.5	1.0	3.1	-0.3	0.4	1.8	0.1	1.2
Major Depression (MDD)	0.1	0.1	0.3	0.2	-0.3	0.0	0.6	0.3
Reaction Time	0.3	0.5	2.1	-0.0	0.5	-1.4	-0.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.9	-0.9	1.4	0.3	-1.0	1.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	3.2	4.2	6.7	2.6	-2.3	1.5	2.4	1.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.5	0.8	-0.7	0.9	0.8	-0.7	-0.3
Bipolar Disorder (2011)	0.3	0.3	0.9	-1.0	0.3	0.0	-0.7	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.6	-1.0	0.5	0.0	-0.8	-1.2
Coronary Artery Disease (CAD)	0.7	0.8	1.5	-1.2	0.8	0.0	-0.8	-1.1
Crohns Disease (2012)	0.7	1.1	1.9	1.4	-1.2	0.0	1.4	-0.1
Mean Putamen Volume	0.7	0.8	2.0	1.1	-0.7	0.4	0.5	1.4
Fasting Glucose	0.5	0.6	2.5	0.1	-0.4	0.3	0.5	-1.6
HbA1C	1.9	2.1	5.9	-1.2	0.5	-1.4	-1.0	-2.4
HDL Cholesterol	0.5	0.8	1.9	-0.5	1.0	0.0	-0.9	1.4
LDL Cholesterol	0.5	0.7	3.3	0.5	0.2	0.0	0.1	1.8
Lupus	0.4	0.5	1.1	0.8	0.1	0.7	0.7	1.1
Neuroticism (2016)	0.5	0.8	1.3	1.0	-1.0	0.7	1.1	-0.2
Primary Biliary Cirrhosis	0.5	0.7	1.2	0.8	-1.1	0.4	1.1	0.4
Rheumatoid Arthritis	0.3	0.4	0.7	0.8	-0.7	0.0	0.7	0.6
Schizophrenia (2014)	0.8	1.7	3.8	-1.9	1.2	0.0	-1.7	-0.4
Triglycerides	0.7	1.1	2.4	1.4	-1.0	0.0	1.6	-0.3
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.4	-1.8	1.4	0.0	-1.5	-0.7
Ulcerative Colitis	0.1	0.1	0.4	0.1	-0.2	0.0	0.5	-0.7
Blood Eosinophil Count	0.5	3.6	8.8	-1.4	3.0	-1.2	-2.3	0.8
Blood Platelet Count	21.8	253.1	400.0	19.2	-19.4	8.9	20.0	6.4
Blood Red Count	0.4	4.0	18.3	-0.6	-0.9	-0.8	0.1	-4.3
Blood White Count	0.1	0.9	4.0	0.2	-0.7	-2.0	0.3	0.1
Heel T-Score	4.1	32.2	48.6	7.0	-5.9	3.8	6.7	4.2
BMI	0.7	4.0	10.8	-0.4	0.6	-2.9	-0.6	-3.3
Height	0.2	4.2	17.9	0.1	-0.2	1.5	0.9	-4.2
Waist Hip Ratio (WHR)	0.5	2.4	10.6	-0.3	1.0	0.4	-0.4	3.2
Systolic Blood Pressure	0.3	1.6	3.0	1.3	-1.7	0.8	1.4	-0.9
Smoking Status	0.1	0.3	1.2	0.0	-0.2	-1.1	0.1	-0.3
Allergy or Eczema	0.1	0.2	0.4	0.6	0.6	-0.7	0.0	-0.1
Cardiovascular Disease	3.2	10.5	17.1	3.7	-4.1	1.9	4.1	-0.9
Hypothyroidism (self reported)	0.9	2.1	3.4	1.5	-1.8	1.4	1.6	0.1
Respiratory disease	0.1	0.2	0.4	0.4	0.0	0.6	-0.3	0.7
Type 2 Diabetes (T2D) (2018)	1.3	2.5	7.0	-1.7	0.8	-1.1	-1.0	-2.6
Lung FEV1/FVC ratio	0.4	2.0	7.8	1.1	-0.0	-2.8	0.6	-0.9
Lung FVC	1.5	7.7	16.6	-3.1	4.1	-1.5	-3.1	1.0
Neuroticism	2.0	4.8	10.7	1.7	-1.8	3.3	2.1	1.6
Chronotype (morning person)	2.3	5.2	6.9	2.6	-2.0	2.6	2.4	1.6
Hair Pigment	0.1	1.5	2.9	1.7	-1.4	0.3	1.6	0.3
Tanning	0.1	0.9	1.9	-0.6	1.2	0.8	-0.5	1.4
Hand grip strength (left)	0.9	2.4	5.1	-1.5	2.3	-0.2	-1.8	-1.2
Number of treatments/medications taken	0.6	1.0	1.6	1.2	-1.2	-0.1	1.3	0.8
Average weekly spirits intake	1.5	1.9	2.9	1.4	-1.7	-0.1	1.6	-1.4
Sensitivity / hurt feelings	0.2	0.4	1.6	0.1	-0.3	1.3	0.3	-0.4
Frequency of depressed mood in last 2 weeks	4.4	6.2	9.5	2.6	-3.1	2.1	2.9	1.4
Hearing difficulty/problems: Yes	0.9	1.4	5.2	0.5	0.3	1.2	0.1	2.3
Relative age of first facial hair	0.5	1.0	3.5	-0.8	0.5	1.9	-0.4	0.8
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.4	1.2	-1.1	0.2	1.0	0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.2	-0.7	-0.2	-1.8	0.0	-1.0
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	0.8	-0.4	0.2	0.7	0.5
Systolic blood pressure, automated reading	0.2	0.5	1.0	0.6	-0.8	0.3	0.7	-1.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.0	-0.2
Angina	0.2	0.3	0.7	0.3	-0.6	-0.8	0.5	0.2
Medication for hormone replacement therapy	0.7	0.7	3.2	-0.5	0.3	0.4	-0.1	1.8
Vitamin and mineral supplements	0.1	0.1	0.1	-0.4	0.1	0.3	-0.3	-0.1
Supplements: Zinc	1.9	2.1	3.4	1.6	-1.5	1.1	1.8	-1.0
Medication: Co-codamol	0.3	0.4	1.0	0.8	0.0	0.1	0.5	1.0
Medication: Metformin	0.6	0.9	2.0	1.1	-1.1	0.3	1.4	0.2
Diabetes (father)	0.9	1.1	2.0	-0.4	1.4	-0.5	-1.2	1.3
Diabetes (mother)	0.4	0.6	1.2	-0.7	0.5	1.1	-0.7	0.6
Severe depression (siblings)	3.0	3.4	6.4	1.5	-2.2	2.5	1.9	0.4
Pack years adult smoking proportion	0.5	0.8	1.4	-1.2	0.7	-0.7	-1.0	-0.7
Impedance of leg (right)	0.3	1.5	3.3	-1.8	1.2	0.7	-1.2	0.9
Leg fat-free mass (left)	0.5	2.5	10.3	0.9	-0.6	-0.2	0.9	-3.2
Trunk fat percentage	0.2	1.0	1.4	-1.2	0.8	-1.0	-0.9	-1.0
Hand grip strength (right)	1.3	3.4	6.9	-2.1	2.6	-0.0	-2.2	-1.0
Townsend deprivation index at recruitment	2.3	3.3	4.2	2.0	-1.9	1.7	2.0	1.2
Current tobacco smoking	0.3	0.5	0.8	0.7	-0.7	-0.9	0.7	-0.7
Average weekly fortified wine intake	0.8	0.9	3.7	0.6	-0.3	-1.9	0.3	0.3
Maternal smoking around birth	0.8	1.2	2.5	1.6	-1.1	-0.2	1.5	0.2
Fed-up feelings	1.6	3.0	5.7	1.5	-2.3	1.2	2.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	2.4	1.0	-1.4	1.6	1.1	1.2
Relative age voice broke	0.7	1.1	2.6	-1.6	1.1	0.2	-1.3	0.0
Taking other prescription medications	0.1	0.1	0.5	0.1	-0.7	-0.4	0.2	-0.2
Age when periods started (menarche)	0.7	1.7	3.8	-1.7	0.4	-0.2	-1.2	-1.9
Bilateral oophorectomy (both ovaries removed)	2.9	3.3	6.6	2.0	-2.6	0.8	2.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	10.3	3.2	-2.3	2.1	2.8	2.0
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.4	0.3	0.2	-0.1	0.4	0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.1	0.4	-0.5	0.0	-0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.0	-0.2	-0.3	0.0	0.5
High blood pressure	3.8	10.7	16.3	3.7	-3.9	2.9	4.0	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	0.9	0.9	0.9	-0.9	-0.0	0.9
Multivitamins +/- minerals	0.9	1.1	2.0	1.4	-1.0	0.1	1.4	0.7
Stomach or abdominal pain in last month	1.7	2.1	4.1	1.7	-2.0	-0.6	1.6	-0.7
Supplements: Glucosamine	2.3	3.0	6.2	-1.8	2.5	-1.4	-1.9	0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.5	-0.1	-0.6	-0.7	0.0	-0.5
Medication: Atenolol	2.1	2.6	4.3	2.1	-1.5	0.8	1.9	1.4
Medication: Levothyroxine sodium	0.7	1.2	1.6	1.1	-1.3	1.2	0.9	1.1
Sitting height	0.5	3.4	5.1	1.3	-1.8	1.7	2.0	-2.3
Chronic bronchitis/emphysema (father)	0.8	1.0	1.2	-1.0	0.6	-1.1	-1.1	-1.1
High blood pressure (mother)	2.8	3.9	5.5	2.1	-2.2	2.0	2.3	0.7
Body mass index (BMI)	0.5	2.1	4.6	-0.7	0.9	-2.2	-0.8	-2.0
Impedance of leg (left)	0.3	1.4	3.2	-1.8	1.1	0.7	-1.2	0.9
Leg predicted mass (left)	0.5	2.6	10.9	0.9	-0.7	-0.3	0.9	-3.3
Trunk fat mass	0.3	1.3	3.7	-0.9	0.7	-1.0	-0.7	-1.9
Waist circumference	0.1	0.2	0.7	0.2	0.2	-0.6	0.3	-0.9
Number of incorrect matches in round	1.9	3.2	5.7	-1.9	1.6	-1.5	-2.4	-1.2
Past tobacco smoking	0.5	0.8	1.7	-1.3	0.6	-0.2	-1.0	-1.0
Alcohol usually taken with meals	1.5	2.4	3.8	2.0	-1.6	1.2	1.8	1.1
Nervous feelings	0.4	0.7	1.4	-1.1	0.8	-0.6	-1.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.7	1.0	-1.3	-0.0	1.1	-0.4
Hearing difficulty/problems with background noise	1.2	2.0	6.1	1.3	-0.7	0.7	1.1	2.5
Hair/balding pattern: Pattern 2	3.8	4.8	6.7	2.4	-1.9	2.6	2.4	1.7
Had menopause	3.9	4.9	8.3	-2.8	2.9	-1.4	-2.3	0.9
Had other major operations	3.5	4.3	8.7	2.4	-3.0	0.2	2.6	0.5
Forced vital capacity (FVC)	0.4	1.4	2.9	-1.4	1.7	0.6	-1.0	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	9.9	3.2	-2.0	1.8	2.6	2.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.1	-0.6	0.8	-0.3	-0.6	1.4
Qualifications: None of the above	0.6	1.3	5.3	0.1	-0.1	-2.3	-0.1	-1.1
Financial difficulties in last 2 years	0.1	0.1	0.2	0.1	0.4	-0.3	-0.0	-0.5
Mouth/teeth dental problems	0.0	0.1	0.2	-0.2	-0.1	0.2	-0.2	-0.4
Heart attack	0.3	0.4	1.1	0.8	-1.1	-0.1	0.6	0.4
Allergy	0.3	0.6	1.3	-0.5	-0.8	1.1	0.4	-0.8
Pain all over the body in last month	0.2	0.2	0.6	0.5	-0.2	-0.4	0.3	-0.8
Diabetes (self-reported)	0.5	0.7	1.4	0.5	-1.2	1.0	0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.6	1.3	-1.0	-0.8	1.0	0.6
Medication: Ramipril	0.9	1.1	2.3	1.2	-1.5	0.2	1.2	-0.7
Medication: Simvastatin	1.2	1.7	2.7	1.6	-1.2	0.5	1.4	1.5
Fluid intelligence score	0.3	0.7	1.3	-0.7	0.7	1.1	-0.7	0.8
Illnesses of siblings	6.4	9.0	11.9	-3.1	2.9	-3.2	-3.5	-2.1
Neuroticism score	1.0	2.0	4.2	1.2	-1.4	2.1	1.5	0.4
Weight	0.4	2.1	9.4	-0.3	0.4	-0.9	-0.2	-3.1
Impedance of arm (right)	0.4	1.9	4.5	-0.8	-0.1	2.1	-0.5	2.0
Arm fat percentage (right)	0.3	1.0	1.4	-1.0	0.9	-1.2	-1.1	-0.9
Trunk fat-free mass	0.7	4.2	19.3	0.8	-0.5	-0.4	0.9	-4.4
Hip circumference	0.3	1.5	6.8	-0.2	0.2	-0.7	-0.0	-2.6
Time employed in main current job	1.3	1.5	2.5	-1.2	1.6	-1.2	-1.5	0.1
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.7	-0.7	-0.0	0.7	0.3
Father’s age at death	1.2	1.6	3.0	-1.7	1.3	-0.7	-1.7	-0.3
Worrier / anxious feelings	0.3	0.7	1.6	-0.9	0.5	1.3	-0.5	-0.5
Frequency of tiredness / lethargy in last 2 weeks	3.1	5.0	10.1	2.3	-3.2	0.6	2.9	-1.0
Falls in the last year	0.2	0.2	0.8	0.1	0.4	0.4	-0.1	0.9
Hair/balding pattern: Pattern 3	1.2	1.8	3.5	-1.9	1.3	0.9	-1.5	0.8
Number of live births	0.2	0.4	0.8	0.5	0.0	0.9	0.4	0.8
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	3.3	-1.4	1.8	-0.5	-1.2	-1.1
Pulse rate	4.0	6.8	11.1	3.2	-3.3	0.9	3.3	1.1
Happiness	0.6	0.7	1.0	1.0	-0.9	0.2	0.9	1.0
Noisy workplace	0.5	0.6	3.0	0.0	-0.1	-1.7	-0.1	-0.1
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.4	0.2	0.1	0.6	0.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	1.7	-1.1	1.3	1.3	-0.9	0.9
Mouth/teeth dental problems: Dentures	1.3	2.2	4.3	-1.6	0.7	-2.1	-1.0	-1.7
Asthma	0.2	0.4	1.1	1.0	-0.0	-0.3	0.1	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.2	0.0	-0.5	0.6	0.5	-1.1
Medication: Cholesterol lowering	2.1	3.2	5.6	2.4	-2.1	0.3	2.3	0.6
Depression (self-reported)	1.3	1.5	2.9	1.5	-1.7	0.7	1.5	0.2
Medication: Lansoprazole	0.7	0.8	2.4	-0.9	0.1	-0.6	-0.5	-1.6
Prospective memory result	2.5	3.1	5.1	2.2	-1.4	1.4	2.3	1.4
Lung cancer (father)	1.9	2.2	3.2	-1.8	1.6	-1.6	-1.6	-0.6
Illnesses of mother	1.1	1.4	2.7	-0.9	1.5	-1.7	-1.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	2.8	-1.2	1.7	-0.1	-1.0	-0.7
Pulse wave Arterial Stiffness index	2.4	2.9	5.8	1.6	-1.9	1.2	2.4	-0.8
Impedance of arm (left)	0.5	2.5	6.8	-0.6	0.0	2.3	-0.3	2.6
Arm fat mass (right)	0.4	1.6	4.1	-0.9	0.9	-1.3	-0.9	-2.0
Trunk predicted mass	0.8	4.3	19.8	0.7	-0.5	-0.5	0.9	-4.5
Standing height	0.4	3.6	8.5	0.8	-1.0	2.4	1.4	-2.9
Length of working week for main job	0.8	0.9	1.8	1.4	-1.0	0.1	1.2	0.6
Exposure to tobacco smoke at home	1.6	1.8	2.8	1.1	-1.2	1.7	1.1	1.5
Breastfed as a baby	0.7	0.8	1.5	1.2	-0.8	-0.5	1.2	-0.6
Tense / ‘highly strung’	0.4	0.6	0.9	-0.9	0.4	-0.7	-0.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	4.2	6.4	11.4	3.3	-2.8	1.1	3.4	0.9
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	0.7	-1.1	-0.5	0.7	-0.5
Birth weight of first child	1.3	2.4	3.3	1.3	-1.8	1.7	1.6	1.2
Peak expiratory flow (PEF)	1.2	2.9	5.3	-1.8	2.3	-0.7	-2.0	-1.2
Pulse wave reflection index	0.1	0.1	0.5	-0.1	0.1	0.7	0.2	-0.1
Ever highly irritable/argumentative for 2 days	1.3	1.5	4.0	-0.8	0.6	-2.0	-0.6	-1.5
Loud music exposure frequency	5.9	6.5	12.3	-3.0	3.2	-0.2	-3.5	0.6
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.2	1.2	-1.0	1.8	1.5	-0.8
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.1	1.1	-0.5	1.9	0.8	2.0
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.4	-0.1	-0.9	-0.6	0.1
Medication: Paracetamol	0.2	0.4	1.0	0.5	-0.6	1.0	0.3	0.5
Headache pain in last month	3.3	5.7	8.1	2.3	-2.9	2.5	2.9	0.8
Medication for cholesterol, blood pressure or diabetes	3.7	6.1	10.2	-3.2	2.8	-1.1	-3.2	-1.1
Glaucoma (self-reported)	0.6	0.8	1.8	-1.4	0.5	0.3	-1.3	0.0
Gout (self-reported)	0.4	0.5	1.1	-0.8	1.0	0.4	-0.7	0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.2	1.2	-1.4	1.5	1.2	0.7
Medication: Amlodipine	2.4	3.4	5.1	1.9	-1.8	2.1	2.3	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	1.3	-0.4	-0.0	0.8	0.2
Birth weight	1.0	2.2	4.1	1.1	-0.9	1.9	1.2	2.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.6	-0.4	-0.1	0.7	-0.1
High blood pressure (siblings)	5.8	8.3	11.4	3.0	-2.7	3.1	3.4	2.1
Forced vital capacity (FVC), Best measure	0.4	1.6	3.3	-1.4	1.8	0.7	-1.1	-0.8
Body fat percentage	0.4	1.5	2.0	-1.4	1.1	-1.4	-1.2	-1.1
Leg fat percentage (right)	0.7	2.4	4.5	-1.5	1.5	-2.1	-1.3	-1.2
Arm fat-free mass (right)	0.6	3.3	14.0	0.8	-0.5	-0.7	1.0	-3.7
Exposure to tobacco smoke outside home	2.9	3.9	5.3	2.2	-1.1	2.3	1.9	2.1
Comparative body size at age 10	0.2	0.6	1.2	0.7	-0.8	-0.3	0.8	-1.1
Number of full brothers	0.6	0.7	2.2	-0.4	0.6	-1.5	-0.9	0.2
Worry too long after embarrassment	0.2	0.4	1.7	0.3	-0.2	1.3	0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.5	6.9	2.6	-2.2	1.5	2.4	1.6
Wheeze or whistling in the chest in last year	1.6	2.9	6.3	2.5	-1.8	-0.4	2.2	-0.1
Number of children fathered	1.7	2.0	2.9	1.7	-1.5	1.3	1.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.6	4.8	-1.5	2.2	-1.0	-1.9	-1.2
Age at first live birth	0.4	0.6	1.1	1.1	-0.9	0.4	1.0	-0.2
Pulse wave peak to peak time	2.1	2.5	5.2	-1.6	1.9	-0.9	-2.3	0.6
Health satisfaction	0.1	0.1	0.3	-0.5	0.2	-0.4	-0.4	0.1
Shortness of breath walking on level ground	1.3	1.6	3.0	-1.2	0.8	-1.7	-1.4	-1.0
Qualifications: College or University degree	0.5	1.6	4.0	-0.9	1.2	2.0	-0.5	1.3
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.5	0.3	-0.7	-0.4	-0.8
Mouth/teeth dental problems: Loose teeth	3.2	3.8	6.6	-2.4	2.1	-0.8	-2.6	-1.1
Emphysema/chronic bronchitis	1.3	1.4	3.9	0.2	-1.6	-0.6	0.5	-2.0
Medication for pain relief, constipation, heartburn	0.5	0.8	1.4	-1.1	1.1	-0.1	-1.2	0.3
Neck or shoulder pain in last month	0.8	1.1	2.6	0.8	-0.7	-1.6	0.9	-1.0
Medication: Blood pressure	3.8	6.6	9.2	3.0	-2.7	2.0	2.9	2.1
Angina (self-reported)	0.2	0.3	0.8	0.4	-0.6	-0.9	0.5	0.2
Migraine (self-reported)	0.3	0.4	1.4	0.2	-0.4	1.2	0.2	0.3
Medication: Ibuprofen	0.5	0.6	1.1	0.8	-0.9	0.7	1.0	-0.4
Medication: Allopurinol	0.0	0.0	0.1	-0.1	0.3	-0.0	0.2	-0.2
Medication: Omeprazole	0.5	0.6	1.9	-0.4	-0.5	-0.9	-0.3	-1.4
Medication: Seretide 50 evohaler	1.3	1.5	2.6	-1.2	1.0	-1.6	-1.0	-1.2
Mean time to correctly identify matches	0.1	0.2	0.5	0.4	-0.2	-0.7	0.5	0.3
Heart disease (mother)	1.9	2.3	4.4	1.8	-2.1	0.3	1.9	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	0.6	-0.6	0.2	0.2	1.3
Whole body fat mass	0.3	1.5	3.5	-1.0	0.9	-1.1	-0.8	-1.9
Leg fat mass (right)	0.6	2.3	4.7	-1.1	1.1	-1.8	-1.0	-2.2
Arm predicted mass (right)	0.7	3.4	13.4	1.1	-0.7	-0.6	1.3	-3.7
Pulse rate, automated reading	2.6	8.4	14.5	3.8	-3.7	0.0	3.6	1.0
Alcohol intake frequency.	2.5	5.9	10.3	3.2	-2.7	0.9	3.2	0.9
Comparative height size at age 10	0.5	2.9	9.9	0.9	-0.8	1.3	1.1	-3.1
Number of full sisters	0.3	0.4	1.0	-0.4	0.1	-1.0	-0.3	-0.8
Suffer from ‘nerves’	0.1	0.2	0.8	-0.3	0.4	-0.9	-0.3	-0.1
Overall health rating	0.1	0.1	0.4	0.3	-0.7	-0.2	0.3	-0.3
Chest pain or discomfort	0.2	0.3	0.5	0.7	-0.5	-0.4	0.5	0.3
Had major operations	0.4	0.4	1.4	-0.2	0.4	0.7	-0.4	1.2
Age at last live birth	0.5	0.7	1.0	0.9	-0.7	1.0	0.8	-0.7
Family relationship satisfaction	0.5	0.6	1.2	1.0	-0.8	-0.5	1.1	-0.1
Leg pain on walking	0.4	0.4	1.7	-0.1	0.1	1.3	0.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	2.2	-0.2	-0.4	-1.5	-0.0	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.4	0.9	1.0	-0.5	0.5	0.7	0.5
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.6	-0.3	0.3	-0.8	-0.3	-0.2
Medication: Aspirin	2.6	3.4	6.9	2.4	-2.2	0.2	2.6	0.1
Supplements: Vitamin C	0.8	0.9	1.8	-1.0	1.3	-0.1	-1.3	-0.1
Knee pain experienced in last month	1.0	1.5	2.5	-1.5	1.1	-1.6	-1.3	-0.4
Hypertension (Self-reported)	3.7	10.2	14.8	3.5	-3.8	3.0	3.9	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.1	-0.1	-0.1	-1.5	-0.5	-1.1
Illnesses of father: Heart disease	0.4	0.5	1.0	0.7	-0.7	-0.7	0.4	1.0
Illnesses of siblings: Diabetes	0.7	0.9	2.2	0.5	-1.0	1.5	0.8	0.6
Smoking status: Previous	0.1	0.1	0.6	-0.1	0.4	-0.0	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	2.1	1.2	-1.0	1.0	1.5	-0.7
Whole body fat-free mass	0.6	3.6	15.7	1.0	-0.7	-0.4	1.0	-4.0
Leg fat-free mass (right)	0.5	2.7	9.7	1.3	-1.0	-0.1	1.1	-3.1
Arm fat percentage (left)	0.1	0.6	0.7	-0.7	0.8	-0.8	-0.8	-0.4
Average weekly red wine intake	0.5	0.7	1.7	-0.4	0.3	-1.0	-0.7	-1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.8	-0.5	0.6	-0.2	-0.4	-0.9
Mood swings	2.4	4.3	7.1	2.2	-2.3	1.8	2.7	1.1
Loneliness, isolation	3.3	4.6	6.5	2.1	-2.2	2.5	2.3	1.4
Long-standing illness, disability or infirmity	1.0	1.5	3.0	1.5	-1.7	0.3	1.4	0.3
Ever had bowel cancer screening	0.4	0.4	1.7	-0.5	-0.4	-0.2	-0.0	-1.3
Diabetes diagnosed by doctor	0.4	0.7	1.3	0.6	-1.2	0.4	1.0	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.8	0.9	-0.5	-0.4	0.7	-0.9
Friendships satisfaction	0.1	0.1	0.2	-0.1	0.3	0.3	-0.4	0.4
Qualifications: nursing, teaching	2.3	3.6	5.7	2.4	-1.4	2.0	2.2	1.4
Commuting to job workplace: Walk	0.4	0.4	0.6	0.6	-0.6	0.7	0.6	0.7
Eye problems/disorders: Cataract	1.6	1.8	4.0	1.3	-0.6	1.3	1.2	2.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.9	1.7	-1.1	0.2	1.6	0.3
Medication for cholesterol	1.6	2.4	4.4	-1.7	2.1	-0.6	-2.0	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	-0.5	0.4	-0.8	-0.2	-0.4
Back pain experienced in last month	0.1	0.1	0.3	-0.5	0.3	-0.5	-0.4	-0.0
Mineral and other dietary supplements	2.0	2.7	5.7	1.1	-2.4	0.5	1.4	-2.0
Breast cancer (self-reported)	0.5	0.6	1.4	0.1	-1.1	-0.7	0.4	-1.2
Asthma (self-reported)	0.2	0.3	0.9	1.0	0.1	-0.5	0.0	0.6
Osteoporosis (self-reported)	0.8	0.9	1.4	-0.8	1.0	-1.1	-1.2	-0.7
Osteoarthritis (self-reported)	2.0	2.6	4.7	-2.2	1.7	-1.1	-2.0	-0.6
Medication: Aspirin	3.1	4.0	7.9	2.4	-2.5	0.2	2.8	-0.2
Medication: Gliclazide	1.2	1.3	3.1	1.8	-0.9	-0.3	1.5	0.6
Illnesses of father: None of the above (group 1)	1.5	1.9	3.8	-1.9	1.6	-0.0	-1.7	-0.8
Smoking status: Current	0.6	0.9	1.2	1.1	-0.9	-0.9	1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.9	-1.0	1.7	-0.8	-1.1	0.8
Whole body water mass	0.6	3.7	16.4	0.8	-0.6	-0.4	0.9	-4.0
Leg predicted mass (right)	0.5	2.8	10.2	1.2	-1.0	-0.2	1.1	-3.2
Arm fat mass (left)	0.3	1.1	3.4	-0.6	0.6	-1.0	-0.5	-1.8
Number of self-reported non-cancer illnesses	1.3	2.2	4.3	1.7	-2.1	0.4	1.8	0.4
Average weekly champagne plus white wine intake	0.3	0.4	0.9	0.4	-1.0	0.6	0.7	-0.1
Miserableness	2.2	3.7	7.6	2.0	-2.3	1.4	2.8	-0.1
Guilty feelings	1.1	1.6	3.5	1.1	-0.2	1.9	0.8	1.7
Wears glasses or contact lenses	2.9	3.4	6.1	-1.9	1.6	-2.5	-1.6	-1.4
Ever taken oral contraceptive pill	0.8	0.9	2.8	-0.4	0.8	0.4	-0.7	1.7
Hearing aid user	7.2	8.1	11.5	3.4	-3.2	2.3	3.4	1.6
Mother’s age at death	0.9	1.2	1.5	-1.2	1.1	-0.6	-1.2	-1.2
Financial situation satisfaction	1.8	2.2	4.7	-1.5	1.3	-2.2	-1.4	-0.9
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.0	1.1	-1.4	1.4	1.1	-0.0
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.7	-0.1	-0.3	-0.3	-0.7
Eye problems/disorders: Glaucoma	0.5	0.6	1.9	-0.3	-0.1	1.0	-0.3	1.4
Medication: Blood pressure	3.6	6.9	11.9	3.1	-3.5	1.3	3.3	-0.5
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	-0.1	-0.1	0.2	0.1	0.0
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.9	-0.7	1.7	-0.4	-1.0	2.2
High cholesterol (Self-reported)	1.8	3.2	6.2	2.5	-1.8	1.0	2.1	1.0
Medication: Bendroflumethiazide	1.7	2.5	4.5	2.1	-1.8	0.2	2.1	0.8
Medication: Paracetamol	0.4	0.7	1.9	0.6	-1.0	1.4	0.4	0.3
Medication: Lisinopril	2.8	3.7	6.7	2.5	-2.0	0.2	2.6	1.1
Medication: Atorvastatin	1.8	2.2	4.2	1.5	-1.5	2.0	1.4	0.8
Illnesses of father: High blood pressure	2.2	2.7	4.8	1.9	-0.9	2.2	1.8	1.3
Alcohol drinker status: Never	0.5	0.6	2.2	-0.0	-0.8	-0.3	0.3	-1.5
Ever smoked	2.8	5.0	9.9	3.1	-2.3	0.7	2.8	1.1
Basal metabolic rate	0.6	3.3	15.0	0.7	-0.5	-0.5	0.8	-3.9
Leg fat percentage (left)	0.6	2.3	4.5	-1.4	1.3	-2.1	-1.3	-1.2
Arm fat-free mass (left)	0.8	3.9	17.6	0.6	-0.5	-1.0	0.8	-4.2
Number of operations (self-reported)	2.5	3.7	4.4	1.9	-2.1	1.8	1.9	1.9
Average weekly beer plus cider intake	0.9	1.3	3.0	-0.5	1.5	-1.7	-1.0	-0.2
Irritability	0.0	0.1	0.3	-0.1	0.1	-0.5	-0.1	-0.2
Risk taking	0.4	0.6	1.4	0.2	-0.2	-1.2	0.1	-1.1
Ever had prostate specific antigen (PSA) test	3.4	3.9	6.2	2.2	-2.1	1.6	2.5	1.0
Fractured/broken bones in last 5 years	0.2	0.2	0.8	0.3	-0.5	0.9	0.2	0.2
Age started oral contraceptive pill	0.1	0.1	0.3	-0.3	-0.1	0.6	-0.2	-0.2
Diastolic blood pressure, automated reading	4.0	12.5	21.0	4.2	-4.4	1.9	4.6	-0.9
Ever depressed for a whole week	0.4	0.5	0.9	-0.3	0.9	-0.7	-0.6	0.9
Unable to work because of sickness or disability	0.3	0.5	0.9	0.6	-1.0	-0.3	0.9	0.2
Commuting to job workplace: Cycle	0.2	0.3	0.5	0.7	-0.7	-0.4	0.3	0.2
Myopia	1.1	1.6	4.2	-2.1	0.9	0.2	-1.6	-0.4
Vascular/heart problems diagnosed by doctor	3.2	8.8	14.1	-3.4	3.8	-2.1	-3.7	-0.3
Cholesterol lowering medication	0.8	1.2	2.2	1.3	-1.3	0.4	1.5	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.0	-0.6	-0.3	-1.0	-0.6	-1.4
Pain experienced in last month	0.1	0.2	0.5	0.3	-0.3	0.7	0.3	0.3
Supplements: Calcium	0.4	0.4	0.9	1.0	0.0	0.5	0.9	0.4
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	0.4	-0.2	0.6	0.8	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	0.7	-0.9	-0.1	0.4	0.4
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.5	0.0	-1.1	-0.7	0.1
Heart disease (siblings)	5.2	6.4	9.2	2.9	-3.0	2.3	2.9	1.1
Alcohol drinker status: Previous	0.7	0.8	1.2	1.1	-0.9	0.1	0.9	1.0
Pack years of smoking	0.5	0.8	1.6	-1.3	0.7	-0.6	-1.1	-0.6
Impedance of whole body	0.4	2.1	5.3	-1.0	0.2	2.0	-0.4	2.3
Leg fat mass (left)	0.5	2.1	4.2	-1.1	1.1	-1.7	-1.0	-2.1
Arm predicted mass (left)	0.7	3.7	17.0	0.2	-0.0	-1.0	0.4	-4.1