Hub : Genes

NBAS

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1370	0.0300	2.2e-16	0.136	0.150	0.151	0.155	0.145	3.1e-16	7.7e-18	6.1e-18	2.0e-18	2.9e-17
2	GTEx	Brain Cerebellar Hemisphere	0.2880	0.0820	7.0e-05	0.220	NA	0.170	NA	0.168	2.4e-06	NA	3.9e-05	NA	4.4e-05
3	GTEx	Brain Cerebellum	0.2420	0.0790	3.8e-04	0.058	NA	0.075	NA	0.062	8.3e-03	NA	3.1e-03	NA	6.5e-03
4	GTEx	Brain Cortex	0.1470	0.0630	5.5e-03	0.103	NA	0.053	NA	0.088	8.9e-04	NA	1.4e-02	NA	2.0e-03
5	GTEx	Brain Frontal Cortex BA9	0.2876	0.1065	1.9e-03	0.002	NA	-0.001	NA	0.042	2.8e-01	NA	3.5e-01	NA	2.8e-02
6	GTEx	Heart Atrial Appendage	0.2930	0.0680	2.6e-08	0.114	NA	0.154	NA	0.174	8.9e-06	NA	2.0e-07	NA	3.1e-08
7	GTEx	Heart Left Ventricle	0.1116	0.0473	3.6e-03	0.012	NA	0.010	NA	0.006	7.2e-02	NA	8.6e-02	NA	1.4e-01
8	GTEx	Nerve Tibial	0.1140	0.0363	2.2e-05	0.088	NA	0.041	NA	0.066	8.9e-07	NA	6.6e-04	NA	2.1e-05
9	GTEx	Testis	0.1870	0.0540	5.6e-07	0.148	NA	0.155	NA	0.147	4.1e-07	NA	2.1e-07	NA	4.5e-07
10	GTEx	Thyroid	0.0790	0.0300	4.9e-04	0.047	NA	0.040	NA	0.046	1.7e-04	NA	4.5e-04	NA	2.0e-04
11	ROSMAP	Brain Pre-frontal Cortex	0.0411	0.0181	3.2e-03	0.020	0.018	0.013	0.018	0.011	1.0e-03	1.7e-03	6.7e-03	2.0e-03	1.2e-02
12	YFS	Blood	0.0156	0.0071	4.3e-03	0.006	0.003	0.003	0.004	0.006	4.7e-03	2.4e-02	2.6e-02	1.9e-02	4.0e-03
13	TCGA	Thyroid Carcinoma	0.0240	0.0140	1.0e-02	0.019	0.013	-0.002	NA	0.003	5.0e-03	1.9e-02	6.6e-01	NA	1.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.2	0.3	1.8	0.2	0.2	-0.3	-0.1	1.1	-0.2	0.4	0.1	-1.4	0.3	0.3	0.1	0.1
Bipolar Disorder or Schizophrenia	1.7	4.1	13.6	-2.0	-1.6	-1.8	-1.9	-1.7	1.9	1.8	-2.2	-3.7	-1.8	-1.4	2.2	-1.5
Depressed Affect (Nagel 2018)	1.1	2.4	7.9	-1.6	-1.4	-2.8	-1.8	0.4	1.2	1.2	-1.8	-2.1	-1.1	-0.8	0.8	-1.5
Depression (Nagel 2018)	1.6	2.3	4.3	-1.3	-1.6	-2.1	-1.4	-0.7	1.4	1.2	-2.0	-2.0	-1.6	-1.2	1.3	-1.4
Intelligence (Savage-Jansen 2018)	1.4	4.3	9.2	2.0	2.0	2.6	2.1	1.8	-2.1	-1.5	1.9	3.0	2.6	1.0	-1.7	1.8
Neuroticism (Nagel 2018)	0.3	0.7	3.2	-0.6	-0.7	-1.4	-0.5	1.6	0.1	-0.2	-0.6	-1.8	-0.1	0.4	0.2	0.1
Schizophrenia (2018)	3.2	6.5	13.4	-2.7	-2.2	-2.0	-2.3	-3.1	2.5	2.0	-2.8	-3.7	-2.5	-2.1	2.8	-2.0
Schizophrenia vs Biploar Disorder	2.1	2.8	5.6	-2.4	-1.3	-1.1	-1.6	-2.3	1.9	1.1	-1.9	-0.6	-1.3	-1.2	2.2	-1.6
Worry (Nagel 2018)	0.4	0.9	2.3	0.1	0.0	0.0	0.5	1.5	-0.9	-1.5	0.6	-1.2	1.1	1.0	-0.8	1.3
Alzheimer’s Disease (in mother)	0.6	0.7	3.4	-0.6	-0.8	-1.1	-0.7	-0.6	0.5	0.4	-0.8	-1.8	-0.9	-0.6	0.8	-0.7
Alzheimer’s Disease (in father)	0.5	0.5	1.8	-0.3	-0.8	-0.5	-0.6	-1.4	0.7	0.5	-0.4	-0.7	-0.8	-0.6	0.9	-0.4
Alzheimer’s Disease (including proxy)	0.6	0.8	2.3	-0.5	-0.9	-1.0	-0.7	-1.1	0.6	0.4	-0.8	-1.5	-1.0	-0.5	1.1	-0.7
Crohns Disease (2017)	0.5	1.1	2.4	-1.1	-1.0	-1.1	-1.0	-1.1	1.3	1.4	-0.9	-0.7	-1.6	-0.7	0.6	-0.9
Irritable Bowel Disease (IBD)	0.6	1.4	2.6	-1.2	-1.0	-1.4	-1.3	-0.5	1.4	1.4	-1.1	-0.2	-1.6	-1.4	0.3	-1.3
Ulcerative Colitis (UC)	0.6	1.2	2.2	-1.0	-0.8	-1.3	-1.4	0.3	1.3	1.2	-1.1	0.0	-1.2	-1.5	0.6	-1.3
Major Depression (MDD)	1.5	1.8	6.4	-0.9	-1.3	-1.9	-1.1	-1.8	0.9	1.7	-0.9	-2.5	-1.1	-0.3	0.7	-0.8
Reaction Time	0.7	1.4	2.9	-1.5	-0.7	-1.0	-1.2	-0.4	1.6	0.3	-1.5	0.5	-0.6	-1.7	1.6	-1.3
Verbal and Numeric Reasoning (VNR)	1.0	2.4	7.5	1.0	1.4	1.4	1.4	1.7	-1.4	-1.3	1.2	2.7	2.2	1.1	-1.2	1.1
Breast Cancer	0.3	0.7	3.1	-1.1	-0.7	-0.2	-0.6	-1.1	0.4	0.7	-0.6	-1.8	-0.5	-0.5	-1.1	-0.7
Ovarian Cancer	0.3	0.4	1.9	-0.7	-0.7	-0.7	-0.6	-1.4	0.5	0.1	-0.7	-0.4	-0.1	-0.4	0.2	-0.6
Prostate Cancer	2.0	2.8	8.9	1.4	1.3	1.8	1.8	-0.0	-1.7	-1.3	1.9	3.0	1.6	1.7	-1.1	1.7
Age at First Birth	0.6	0.9	4.0	0.2	0.8	1.2	0.5	0.3	-1.0	-1.0	1.0	-0.3	1.1	0.2	-2.0	0.8
Bipolar Disorder (2011)	0.1	0.1	1.0	0.0	0.0	-0.4	-0.1	1.0	0.1	-0.2	-0.2	-0.1	-0.5	0.3	0.1	-0.1
Body Mass Index (BMI) (2010)	0.6	0.8	2.7	-0.9	-0.1	-0.4	-0.7	-1.6	0.6	-0.3	-1.1	-1.7	-0.6	-0.5	0.5	-0.8
Coronary Artery Disease (CAD)	0.1	0.2	0.8	-0.2	-0.2	0.2	-0.2	0.8	0.3	-0.1	-0.3	0.9	0.2	0.0	0.6	-0.1
Crohns Disease (2012)	0.3	0.5	1.1	-0.9	-0.5	-0.7	-0.6	-1.0	0.8	0.4	-0.5	-0.8	-0.7	-0.3	0.2	-0.7
Mean Putamen Volume	3.5	4.0	7.4	-2.1	-2.6	-2.7	-2.1	-1.4	1.9	1.9	-2.1	-1.8	-1.4	-2.2	1.0	-2.0
Fasting Glucose	0.6	0.7	2.8	-1.7	-0.9	-0.7	-0.9	-0.4	1.1	0.2	-0.4	0.1	-1.1	-0.3	0.0	-1.1
HbA1C	0.9	1.0	2.2	-1.2	-1.2	-1.3	-1.2	-0.8	1.0	-0.5	-1.5	-1.3	-0.5	0.1	0.4	-1.2
HDL Cholesterol	1.2	2.0	3.2	1.3	1.1	1.6	1.2	1.3	-1.2	-1.5	1.3	1.8	1.7	1.5	-1.2	1.3
LDL Cholesterol	0.3	0.4	0.8	-0.7	-0.6	-0.6	-0.6	0.8	0.6	0.7	-0.5	-0.2	-0.5	-0.8	0.7	-0.9
Lupus	0.1	0.1	0.4	0.2	-0.3	0.1	0.3	0.3	-0.1	0.1	0.2	0.7	0.3	-0.2	0.5	0.3
Neuroticism (2016)	0.3	0.4	2.6	-0.3	0.6	0.1	-0.2	0.5	-0.3	-0.6	0.0	-1.6	-0.1	0.4	-0.8	0.3
Primary Biliary Cirrhosis	1.7	2.4	5.2	-1.1	-1.7	-2.3	-1.6	-0.6	1.6	1.3	-1.7	-0.5	-1.9	-1.6	1.4	-1.7
Rheumatoid Arthritis	0.1	0.1	0.5	0.5	-0.1	-0.3	0.2	0.7	-0.2	-0.6	0.3	0.3	0.4	0.2	-0.1	0.1
Schizophrenia (2014)	3.0	6.6	11.8	-2.8	-2.5	-2.1	-2.5	-2.4	2.6	2.6	-2.9	-3.4	-2.2	-2.0	2.9	-2.1
Triglycerides	2.5	4.1	6.5	-2.5	-2.5	-2.2	-1.6	-2.0	1.9	2.5	-1.9	-2.0	-1.5	-1.6	2.0	-1.8
Type 2 Diabetes (T2D) (2012)	1.2	1.4	4.0	-1.0	-1.2	-1.2	-1.0	0.0	1.4	0.4	-1.4	-1.3	-1.0	-1.2	2.0	-1.0
Ulcerative Colitis	0.8	1.2	2.5	-1.0	-1.0	-1.3	-1.4	-0.7	1.3	0.8	-1.3	-0.3	-1.1	-0.9	0.9	-1.6
Blood Eosinophil Count	0.0	0.3	2.0	0.2	-0.2	-0.6	-0.3	1.4	0.6	0.6	-0.3	0.4	-0.2	0.7	0.3	-0.1
Blood Platelet Count	0.0	0.4	1.8	-0.9	-0.5	-1.3	-0.7	-0.3	0.6	0.5	-0.1	-0.3	-0.7	0.1	0.3	-0.3
Blood Red Count	0.1	1.1	3.2	-0.7	-1.1	-0.7	-0.9	-0.6	0.9	0.3	-0.9	-1.8	-1.3	-1.7	0.4	-0.6
Blood White Count	0.6	4.2	6.7	-2.2	-2.0	-2.2	-2.1	-2.6	2.6	1.1	-2.4	-1.1	-2.3	-2.2	1.5	-1.7
Heel T-Score	0.1	0.9	2.0	0.6	1.1	0.8	1.0	0.9	-1.0	-1.1	0.8	1.3	0.8	-0.5	-1.4	0.5
BMI	2.2	12.5	18.8	-4.2	-2.8	-2.7	-3.9	-2.9	4.0	2.6	-4.3	-3.3	-4.1	-4.0	3.0	-3.3
Height	0.0	0.3	1.3	1.1	0.8	0.1	0.6	-0.7	-0.6	0.6	0.4	-0.1	0.6	0.5	0.0	0.2
Waist Hip Ratio (WHR)	0.7	3.1	5.9	-1.2	-2.4	-2.0	-1.7	-1.7	1.9	1.0	-1.6	-2.2	-2.2	-1.0	1.8	-1.4
Systolic Blood Pressure	0.8	4.2	8.8	-1.8	-2.2	-1.7	-1.8	-0.9	2.0	2.8	-2.0	-3.0	-2.3	-2.1	1.7	-1.4
Smoking Status	1.6	3.9	12.6	-1.2	-1.5	-1.7	-1.6	-3.5	1.9	1.6	-2.1	-2.4	-2.1	-1.6	1.5	-2.1
Allergy or Eczema	0.4	1.0	2.8	0.3	0.8	0.6	0.6	1.1	-0.9	-1.4	0.8	0.9	0.6	1.5	-1.7	0.8
Cardiovascular Disease	0.3	1.1	3.1	-0.7	-1.4	-1.1	-1.1	-0.5	1.1	0.5	-1.2	-0.8	-1.7	-0.5	1.3	-1.1
Hypothyroidism (self reported)	0.4	0.9	2.0	-0.2	-0.9	-1.2	-1.0	-0.3	1.1	1.2	-1.1	0.4	-1.4	-0.3	1.1	-1.2
Respiratory disease	0.1	0.1	0.4	-0.3	-0.0	-0.2	-0.3	-0.6	0.4	-0.5	-0.4	-0.6	-0.4	0.0	0.5	0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.3	1.4	0.8	0.2	0.7	0.4	-0.0	-0.5	-1.2	0.0	0.1	0.3	0.5	-0.1	0.4
Lung FEV1/FVC ratio	2.1	10.5	26.3	-1.6	-3.9	-5.1	-2.8	-3.9	3.6	2.4	-3.3	-2.6	-3.5	-1.6	3.5	-2.5
Lung FVC	0.2	0.8	3.8	-0.3	-0.7	-2.0	-0.6	0.5	0.7	0.5	-0.5	-1.5	-0.8	-0.0	1.0	0.0
Neuroticism	0.2	0.5	4.4	-0.0	-0.3	-0.7	-0.3	1.0	-0.3	-0.1	0.1	-2.1	-0.1	0.3	-0.2	0.3
Chronotype (morning person)	0.1	0.1	0.4	0.3	0.4	-0.4	-0.1	0.6	-0.2	-0.1	0.5	0.5	0.0	0.4	-0.2	-0.1
Hair Pigment	0.1	1.7	3.4	-1.0	-1.9	-1.4	-1.0	-1.1	1.5	1.2	-1.7	-0.9	-0.9	-1.0	1.5	-1.3
Tanning	0.1	1.1	2.0	1.4	1.2	0.8	1.0	1.0	-1.2	-0.4	1.3	1.1	1.0	1.1	-0.5	0.8
Hand grip strength (left)	0.4	1.0	2.8	-1.0	0.0	-0.1	-0.8	-1.7	1.3	-0.0	-1.2	-1.6	-1.4	-0.4	0.7	-0.9
Number of treatments/medications taken	0.4	0.7	1.9	-0.9	-0.7	-0.8	-0.6	-1.0	0.8	1.0	-0.7	-1.1	-1.4	0.6	0.5	-0.7
Average weekly spirits intake	0.7	0.8	2.7	0.3	0.6	0.7	0.4	-0.4	-1.3	-1.1	0.6	0.9	1.1	0.7	-1.7	1.0
Sensitivity / hurt feelings	2.0	3.4	6.9	1.6	2.2	2.6	2.0	1.0	-2.0	-1.3	2.2	0.3	1.7	1.2	-2.0	2.3
Frequency of depressed mood in last 2 weeks	2.7	3.8	7.2	-2.0	-1.9	-2.3	-1.9	-1.4	1.8	1.7	-2.4	-2.7	-2.1	-1.5	1.4	-1.8
Hearing difficulty/problems: Yes	4.2	6.4	9.0	-2.5	-2.0	-3.0	-2.7	-1.8	3.0	2.3	-2.8	-2.4	-2.1	-2.5	2.7	-2.7
Relative age of first facial hair	1.3	2.6	6.2	1.5	1.3	1.4	1.4	2.5	-1.9	-0.3	1.4	0.7	1.7	1.7	-2.2	1.7
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.2	-1.1	-1.5	-1.4	-1.1	0.1	1.3	0.2	-1.2	-1.1	-1.1	-0.6	1.2	-1.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.0	0.8	0.7	0.2	0.7	-0.4	-0.5	-0.2	0.7	0.8	-0.1	1.0	-0.2	-0.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.0	0.7	0.3	-0.1	0.6	-0.7	-0.6	0.5	0.6	0.5	0.7	0.7	-1.0	0.1
Systolic blood pressure, automated reading	1.7	4.9	9.0	-2.2	-1.7	-1.8	-2.1	0.3	2.5	3.0	-2.1	-2.5	-2.3	-3.0	2.5	-1.5
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	0.1	-0.4	-0.7	-0.1	0.3	0.2	0.8	-0.1	-0.6	-0.5	0.1	0.0	-0.0
Angina	0.1	0.1	0.5	0.3	0.2	-0.1	0.1	-0.4	0.1	-0.3	0.3	0.1	-0.2	0.3	0.7	-0.1
Medication for hormone replacement therapy	0.4	0.4	2.7	0.1	0.3	-0.6	0.4	-1.6	-0.3	0.3	0.0	-1.2	-0.0	-0.7	-0.3	0.0
Vitamin and mineral supplements	2.0	2.7	8.8	1.5	1.4	1.6	1.3	3.0	-1.6	-1.3	1.2	1.8	1.9	1.3	-1.0	1.6
Supplements: Zinc	0.4	0.4	1.4	-1.2	-0.4	-0.7	-0.6	-0.8	0.6	0.1	-0.3	0.2	0.1	-1.1	0.5	-0.2
Medication: Co-codamol	3.6	4.2	5.9	-2.4	-1.9	-2.3	-2.2	-1.4	2.2	2.3	-2.2	-2.4	-1.8	-1.0	1.7	-2.2
Medication: Metformin	0.1	0.2	1.3	0.1	-0.6	-0.1	-0.4	-1.1	0.0	-0.1	-0.5	-0.7	-0.0	0.3	0.2	-0.3
Diabetes (father)	8.1	10.1	20.5	-3.1	-3.0	-2.0	-3.5	-2.6	3.2	3.0	-3.8	-4.5	-3.4	-2.7	2.4	-3.3
Diabetes (mother)	1.9	2.4	3.6	-1.4	-1.4	-1.5	-1.5	-0.3	1.8	1.8	-1.6	-1.5	-1.6	-1.6	1.9	-1.7
Severe depression (siblings)	0.4	0.5	2.8	-0.6	-0.4	-0.7	-0.4	-0.5	0.5	-0.2	-0.9	-1.7	-0.6	-0.5	0.6	-0.2
Pack years adult smoking proportion	0.4	0.6	1.9	-0.2	-0.8	-0.9	-0.6	-0.5	0.7	0.7	-0.5	-1.4	-0.7	-0.3	0.9	-0.7
Impedance of leg (right)	0.3	1.4	3.8	1.2	1.1	0.5	1.1	1.9	-1.1	-1.0	1.8	1.0	1.5	1.2	-0.0	0.8
Leg fat-free mass (left)	1.7	8.7	16.7	-2.8	-2.4	-2.3	-3.0	-4.1	3.1	2.8	-3.5	-2.9	-3.0	-2.9	2.5	-2.8
Trunk fat percentage	2.5	10.2	14.4	-3.8	-2.3	-3.0	-3.6	-2.6	3.8	2.2	-3.5	-2.8	-3.6	-3.6	3.0	-3.1
Hand grip strength (right)	0.2	0.4	1.7	-0.8	0.2	0.3	-0.4	-1.3	0.8	0.3	-0.6	-0.9	-0.9	-0.4	0.2	-0.3
Townsend deprivation index at recruitment	8.8	12.4	16.7	-3.4	-3.6	-3.8	-3.5	-3.1	3.8	3.2	-4.1	-2.9	-4.0	-3.5	3.1	-3.6
Current tobacco smoking	1.0	1.7	3.6	-0.9	-1.3	-1.2	-1.3	-1.9	1.5	0.5	-1.3	-1.3	-1.3	-0.5	1.3	-1.7
Average weekly fortified wine intake	2.2	2.6	5.5	1.4	2.4	1.6	1.8	1.2	-1.7	-1.5	1.7	1.4	1.8	0.6	-1.1	2.1
Maternal smoking around birth	0.2	0.2	0.7	-0.3	-0.2	-0.9	-0.8	0.0	0.4	-0.6	-0.5	-0.0	0.0	0.1	0.0	-0.8
Fed-up feelings	4.3	7.8	10.9	-3.3	-2.7	-3.1	-3.0	-1.8	2.7	2.8	-3.2	-3.2	-2.7	-2.5	1.8	-2.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	5.1	-2.1	-2.0	-2.2	-2.0	-2.1	1.9	1.2	-2.3	-1.9	-1.6	-1.1	1.6	-2.0
Relative age voice broke	0.3	0.4	1.7	0.6	1.2	0.4	0.4	-0.4	-0.8	0.6	0.6	0.3	0.5	-0.0	-1.3	0.2
Taking other prescription medications	0.4	0.7	1.6	-1.1	-0.8	-0.1	-0.8	-0.3	0.9	0.2	-0.8	-1.3	-1.1	0.7	1.2	-0.6
Age when periods started (menarche)	0.4	1.1	3.6	1.9	0.8	1.0	1.3	-0.1	-1.0	-1.5	0.8	0.3	0.8	1.1	-0.3	1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.5	0.8	0.2	0.5	0.9	-1.2	-0.8	-0.5	0.6	0.2	0.5	0.8	0.1	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.2	0.7	0.1	0.0	0.8	-1.1	-0.6	-1.1	0.6	-0.3	0.3	-0.2	-0.9	0.4
Tinnitus: Yes, but not now, but have in the past	1.9	2.1	3.9	-2.0	-1.6	-1.1	-1.7	-0.5	1.8	1.2	-1.9	-0.9	-1.1	-1.0	1.3	-1.7
Qualifications: CSEs or equivalent	1.0	1.3	3.1	-0.9	-1.5	-1.2	-1.1	-0.3	1.2	0.2	-1.1	-1.5	-1.8	-0.5	1.0	-1.6
Serious illness, injury or assault to yourself	0.2	0.3	1.6	-0.3	0.1	-0.6	0.0	-0.3	-0.2	-1.2	-0.1	-0.8	0.1	0.9	0.2	-0.3
High blood pressure	0.9	2.5	4.8	-1.6	-1.5	-1.2	-1.6	-1.4	1.6	1.2	-1.7	-1.8	-2.2	-0.9	2.1	-1.4
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.6	-0.1	0.2	0.3	0.3	0.5	-0.4	-0.9	0.4	0.3	0.0	1.2	-1.1	0.1
Multivitamins +/- minerals	2.1	2.7	8.4	-1.7	-1.4	-1.7	-1.5	-2.9	1.3	1.0	-1.5	-1.5	-1.9	-1.3	0.5	-1.9
Stomach or abdominal pain in last month	0.3	0.4	1.1	0.6	0.8	1.0	0.7	-0.9	-0.6	-0.0	0.5	-0.2	-0.1	0.7	-0.5	0.8
Supplements: Glucosamine	0.8	1.1	2.6	1.0	-0.0	0.3	1.0	-0.5	-1.4	-0.3	1.6	0.8	1.2	1.2	-1.3	1.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.8	-1.2	-1.2	-0.9	-1.1	-0.5	1.0	0.8	-1.2	-2.0	-0.6	-1.0	0.9	-1.0
Medication: Atenolol	1.4	1.8	2.9	-1.6	-1.7	-1.5	-1.3	-0.4	1.4	1.0	-1.5	-1.2	-1.4	-0.9	1.7	-0.9
Medication: Levothyroxine sodium	0.7	1.1	3.1	-0.8	-0.7	-0.6	-1.2	-0.4	1.2	0.7	-1.3	0.1	-1.4	-0.7	1.8	-1.5
Sitting height	0.1	1.0	2.5	-0.8	-0.3	-0.8	-0.9	-1.6	0.7	0.9	-0.9	-1.4	-0.5	-1.5	0.7	-1.2
Chronic bronchitis/emphysema (father)	0.2	0.3	1.0	-0.7	0.3	0.5	-0.4	-0.4	0.1	0.3	-0.0	0.6	1.0	-0.7	-0.3	-0.2
High blood pressure (mother)	0.2	0.2	1.5	0.2	-0.2	-0.2	-0.1	1.0	-0.3	1.2	-0.2	-0.5	0.1	0.3	-0.3	0.0
Body mass index (BMI)	3.5	15.1	20.8	-4.4	-3.2	-3.8	-4.4	-3.4	4.5	3.1	-4.6	-3.5	-4.5	-3.6	3.5	-3.7
Impedance of leg (left)	0.2	1.0	3.5	0.8	0.7	0.2	0.8	1.9	-0.8	-1.3	1.6	0.9	1.1	0.9	-0.1	0.6
Leg predicted mass (left)	1.6	8.4	16.6	-2.7	-2.3	-2.2	-3.0	-4.1	3.0	2.7	-3.4	-2.8	-2.9	-2.9	2.4	-2.7
Trunk fat mass	3.0	12.7	16.8	-4.0	-2.6	-3.4	-4.0	-3.3	4.1	2.8	-3.9	-3.2	-4.0	-3.8	3.3	-3.5
Waist circumference	4.3	15.7	21.6	-4.3	-3.5	-4.1	-4.5	-3.8	4.6	3.0	-4.5	-3.4	-4.7	-3.3	3.6	-3.8
Number of incorrect matches in round	0.3	0.6	3.0	0.1	-0.1	0.8	-0.1	1.7	-0.0	-1.7	-0.1	0.3	0.4	-0.5	0.2	0.2
Past tobacco smoking	1.8	3.3	4.7	1.9	1.1	1.4	1.8	1.9	-1.9	-2.0	2.1	2.1	1.8	2.2	-1.2	2.0
Alcohol usually taken with meals	2.8	4.6	7.2	1.7	2.2	2.7	2.6	1.2	-2.5	-2.3	2.3	1.3	2.0	1.4	-2.7	2.4
Nervous feelings	0.3	0.6	5.4	-0.4	-0.7	-0.3	-0.2	-0.3	-0.0	-1.2	-0.2	-2.3	-0.1	0.2	-0.5	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.9	-0.7	-0.5	-0.8	0.0	-0.7	0.1	-0.5	-0.3	-0.9	0.1	0.9	-0.3	-0.0
Hearing difficulty/problems with background noise	0.1	0.2	1.3	-0.6	0.1	-0.8	-0.2	0.0	0.3	0.4	-0.4	-1.1	0.2	-0.0	0.1	-0.1
Hair/balding pattern: Pattern 2	1.1	1.4	2.4	-1.1	-1.0	-0.8	-1.0	-1.6	1.4	0.2	-1.5	-1.0	-1.4	-0.6	1.5	-1.5
Had menopause	1.4	1.7	3.4	-1.4	-1.2	-1.9	-1.3	-0.6	1.6	1.1	-1.0	-0.5	-1.4	-1.8	1.4	-1.2
Had other major operations	1.4	1.7	5.9	1.3	1.6	2.4	1.5	0.2	-1.3	-0.0	1.2	0.6	1.8	0.7	-0.3	1.4
Forced vital capacity (FVC)	0.5	1.8	4.3	-0.3	-1.3	-1.8	-1.1	-1.7	1.1	1.1	-1.0	-2.1	-1.3	-1.6	1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.6	0.6	0.1	-0.1	0.7	-1.3	-0.7	-0.6	0.4	-0.4	0.2	-0.1	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	3.7	4.5	11.6	-1.6	-1.8	-2.6	-1.7	-3.4	1.8	2.1	-1.7	-2.9	-2.0	-1.7	1.5	-1.7
Qualifications: None of the above	2.9	6.1	9.7	-2.4	-2.3	-3.1	-2.8	-2.2	2.9	1.4	-3.0	-1.5	-2.5	-1.5	2.8	-2.7
Financial difficulties in last 2 years	0.7	1.0	2.4	-0.8	-0.2	-1.5	-0.9	-0.9	1.2	0.9	-1.0	-0.2	-1.1	-0.8	1.3	-1.0
Mouth/teeth dental problems	4.7	7.3	13.2	1.9	2.5	3.1	2.6	2.5	-3.0	-1.9	2.4	3.2	2.7	2.3	-3.6	2.5
Heart attack	0.3	0.4	1.7	-0.1	-0.0	-0.1	-0.6	-0.6	0.3	0.2	-0.4	-1.2	-1.3	0.1	0.9	-0.7
Allergy	0.1	0.2	1.5	0.1	0.0	0.1	-0.1	0.1	0.3	1.2	-0.2	-0.1	-0.2	-1.1	0.5	0.1
Pain all over the body in last month	5.1	5.5	10.3	-2.3	-1.9	-2.1	-2.5	-0.8	2.7	2.2	-2.8	-1.8	-2.2	-2.2	3.2	-2.8
Diabetes (self-reported)	0.1	0.1	0.6	0.8	0.2	0.1	0.2	-0.1	-0.2	-0.5	0.1	-0.1	-0.3	0.4	0.3	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.1	0.5	0.4	0.5	0.3	0.2	-0.5	-1.0	0.2	0.0	0.1	0.6	-0.5	-0.1
Medication: Ramipril	0.4	0.5	1.4	0.4	0.8	1.1	0.7	-0.0	-0.8	-0.6	0.6	0.4	0.5	1.2	0.3	0.6
Medication: Simvastatin	0.2	0.3	1.4	-0.3	-0.7	-0.6	-0.5	-0.0	0.4	0.3	-0.2	0.1	-1.2	0.2	0.4	-0.4
Fluid intelligence score	1.6	3.4	7.1	1.7	2.5	2.7	1.9	0.3	-1.6	-1.7	1.8	2.1	2.0	1.7	-1.2	1.6
Illnesses of siblings	1.0	1.4	3.0	1.4	0.9	1.1	1.2	1.7	-1.3	-0.9	1.3	0.4	0.9	0.5	-1.7	1.2
Neuroticism score	0.5	1.1	7.5	-1.1	-1.0	-1.3	-1.0	-0.3	0.5	0.4	-0.7	-2.7	-0.8	-0.3	0.1	-0.5
Weight	3.2	15.5	20.6	-4.0	-3.1	-3.7	-4.3	-4.5	4.3	3.4	-4.4	-3.7	-4.3	-3.7	3.5	-3.8
Impedance of arm (right)	2.9	13.4	18.2	3.2	3.9	3.6	3.9	3.8	-3.8	-3.5	4.3	3.5	4.2	3.0	-3.1	3.5
Arm fat percentage (right)	2.0	7.8	11.4	-3.4	-1.8	-2.7	-3.2	-2.0	3.4	2.2	-3.2	-2.3	-3.2	-2.9	2.6	-2.7
Trunk fat-free mass	1.2	7.1	14.1	-2.0	-2.1	-2.5	-2.7	-3.8	2.6	2.7	-2.9	-2.9	-2.7	-2.3	2.4	-2.6
Hip circumference	2.6	11.3	15.3	-3.8	-2.6	-3.4	-3.8	-3.6	3.6	3.0	-3.9	-2.7	-3.5	-3.1	3.0	-3.3
Time employed in main current job	2.0	2.3	3.8	-1.9	-1.1	-1.2	-1.7	-0.5	1.8	1.6	-1.6	-1.3	-1.2	-1.8	1.9	-1.8
Alcohol intake versus 10 years previously	0.8	1.3	3.6	-1.4	-1.4	-0.6	-1.3	-0.3	0.8	-0.3	-1.9	-1.7	-0.6	-0.9	0.6	-1.2
Father’s age at death	1.0	1.3	2.3	1.2	0.8	1.2	1.3	0.5	-1.2	-1.5	1.1	1.5	1.4	1.1	-0.4	1.3
Worrier / anxious feelings	0.6	1.2	2.2	1.0	0.6	0.8	1.1	1.0	-1.4	-1.4	1.0	-0.2	1.3	1.5	-0.9	1.2
Frequency of tiredness / lethargy in last 2 weeks	3.8	6.2	14.4	-2.4	-2.5	-2.3	-2.3	-2.1	2.5	2.0	-2.8	-3.8	-2.6	-1.9	1.7	-2.7
Falls in the last year	0.1	0.2	0.7	0.2	0.6	-0.2	0.4	-0.8	-0.0	-0.1	0.1	-0.7	0.4	0.4	0.6	0.2
Hair/balding pattern: Pattern 3	0.1	0.2	1.3	0.5	-0.1	-0.2	0.4	-1.1	-0.1	-0.1	0.1	-0.3	-0.2	-0.5	-0.1	0.5
Number of live births	0.4	0.5	1.0	-0.2	-1.0	-0.9	-0.8	0.6	0.8	0.7	-0.6	0.4	-0.8	-0.2	0.5	-1.0
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	8.1	-0.7	-2.1	-2.8	-1.7	-2.1	1.9	1.4	-1.7	-2.6	-2.0	-1.8	2.0	-1.3
Pulse rate	1.6	2.7	5.3	-2.2	-1.5	-1.3	-1.4	-2.3	1.7	2.2	-1.7	-0.9	-1.3	-1.6	1.6	-0.9
Happiness	1.2	1.4	2.8	-0.9	-1.1	-1.6	-1.7	0.6	1.5	0.9	-1.3	-0.9	-0.9	-0.9	1.4	-1.2
Noisy workplace	2.4	3.0	6.7	-2.1	-1.4	-1.4	-1.9	-2.6	1.5	0.8	-1.8	-2.3	-1.5	-1.3	0.6	-2.0
Qualifications: A levels/AS levels or equivalent	1.3	3.0	8.1	1.7	1.4	2.8	2.0	1.4	-2.0	-2.0	1.5	1.2	1.1	1.4	-1.3	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	0.2	1.0	0.3	0.5	0.2	0.0	-1.1	0.4	-0.3	-0.2	0.0	1.0	0.3
Mouth/teeth dental problems: Dentures	2.9	4.9	9.8	-1.6	-2.1	-2.1	-2.0	-1.7	2.5	1.9	-1.9	-2.8	-2.4	-2.1	3.1	-2.0
Asthma	0.1	0.2	1.1	-0.2	0.0	0.2	-0.1	-0.9	0.0	-1.1	-0.1	-0.2	-0.2	0.5	-0.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.6	-0.2	-0.1	-0.8	-0.2	0.3	0.5	-0.1	-0.2	0.3	-0.2	-0.4	-0.2	-0.1
Medication: Cholesterol lowering	0.1	0.1	0.6	0.1	-0.3	-0.0	-0.3	0.3	0.3	0.4	-0.3	-0.2	-0.8	-0.2	0.4	-0.3
Depression (self-reported)	0.7	0.8	4.7	-0.4	0.2	-0.5	-0.1	-0.3	-0.1	-1.3	-0.0	-2.2	0.7	1.7	-0.6	0.4
Medication: Lansoprazole	3.3	3.7	6.5	-1.9	-1.6	-1.5	-1.8	-1.7	2.0	2.4	-1.9	-2.5	-1.9	-1.6	2.1	-1.9
Prospective memory result	0.8	1.0	1.9	-1.3	-1.3	-1.1	-1.2	-0.8	0.8	0.9	-1.0	-1.4	-0.6	-0.5	1.0	-0.8
Lung cancer (father)	0.3	0.3	1.0	-0.8	0.2	-1.0	-0.7	-0.1	0.4	-0.1	-0.3	-0.4	-0.8	-1.0	-0.3	-0.5
Illnesses of mother	0.2	0.2	1.2	0.2	0.7	0.4	0.5	-1.1	0.0	-0.1	0.2	0.3	0.3	0.4	0.4	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.0	-0.1	-1.4	-2.2	-1.1	-1.9	1.4	0.8	-1.1	-1.7	-1.5	-1.0	1.8	-0.8
Pulse wave Arterial Stiffness index	0.2	0.2	1.2	0.4	-0.1	0.2	0.3	-0.2	-0.3	0.3	0.5	-0.1	1.1	0.2	-0.7	0.7
Impedance of arm (left)	2.5	11.8	16.2	2.9	3.6	3.6	3.6	3.7	-3.5	-3.4	4.0	3.7	3.4	2.7	-3.1	3.1
Arm fat mass (right)	3.2	13.1	17.3	-4.0	-2.7	-3.6	-4.0	-3.2	4.2	3.1	-4.1	-3.5	-4.0	-3.5	3.3	-3.6
Trunk predicted mass	1.3	7.4	14.1	-2.0	-2.2	-2.6	-2.8	-3.8	2.7	2.8	-3.0	-2.9	-2.8	-2.4	2.5	-2.7
Standing height	0.1	1.1	8.1	0.2	-0.3	-0.5	-0.4	-2.9	0.4	1.0	-0.4	-1.4	-0.4	-0.9	0.7	-0.9
Length of working week for main job	0.1	0.1	0.3	0.2	0.3	0.6	0.2	0.3	-0.0	0.3	-0.4	0.4	0.2	0.3	0.6	-0.1
Exposure to tobacco smoke at home	1.7	1.9	3.5	-1.3	-1.4	-1.3	-1.4	-1.5	1.2	1.9	-1.6	-0.9	-1.6	-0.7	1.3	-1.6
Breastfed as a baby	0.1	0.2	0.7	0.4	-0.8	0.2	0.1	-0.1	-0.2	0.8	-0.0	-0.8	0.4	0.1	0.2	-0.1
Tense / ‘highly strung’	0.2	0.4	2.6	-0.5	-0.6	-0.2	-0.1	-0.8	-0.1	-0.7	-0.2	-1.6	-0.0	0.8	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	9.0	-1.0	-1.4	-1.6	-1.1	-2.4	1.0	0.3	-1.1	-3.0	-1.1	-0.1	0.6	-0.6
Hair/balding pattern: Pattern 4	0.3	0.7	1.5	-1.2	-0.8	-0.6	-1.1	0.6	1.0	0.8	-0.8	-0.2	-0.3	-0.7	1.1	-0.8
Birth weight of first child	0.3	0.5	1.2	0.2	1.1	1.0	0.6	-0.8	-0.5	0.8	0.8	-0.6	0.6	0.1	-0.5	0.8
Peak expiratory flow (PEF)	0.2	0.5	1.6	0.3	-0.8	-1.3	-0.7	-0.8	0.8	0.5	-0.7	-1.1	-0.5	-0.3	0.6	-0.3
Pulse wave reflection index	0.7	0.8	2.6	-0.3	-1.4	-1.6	-0.9	-0.7	0.9	0.1	-0.9	-1.4	-0.7	-0.4	0.2	-0.8
Ever highly irritable/argumentative for 2 days	1.2	1.4	4.6	-0.8	-0.6	-1.9	-1.0	-2.1	1.1	1.4	-0.9	-1.6	-0.8	-0.0	0.7	-0.7
Loud music exposure frequency	0.1	0.1	0.9	-0.1	-0.2	-0.0	0.0	0.0	-0.1	-0.1	-0.2	-1.0	-0.1	0.0	-0.7	-0.1
Qualifications: O levels/GCSEs or equivalent	2.6	4.2	7.0	2.2	1.7	2.5	2.4	2.7	-1.9	-1.9	2.4	1.9	1.1	0.9	-2.3	2.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.3	0.6	0.3	0.5	0.9	-0.4	-0.6	0.6	-0.0	0.8	0.0	0.1	0.7
Blood clot in the leg (DVT)	0.5	0.6	1.9	1.4	0.7	0.4	0.7	1.1	-0.7	-1.0	0.6	0.6	0.9	0.6	0.3	0.5
Medication: Paracetamol	1.7	2.8	4.3	-1.8	-1.4	-1.9	-1.8	-1.2	2.1	1.4	-1.9	-0.8	-1.5	-1.5	1.8	-2.0
Headache pain in last month	0.1	0.1	0.8	-0.2	0.1	-0.4	0.1	-0.9	0.2	-0.2	0.1	-0.4	-0.2	0.3	0.2	-0.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	0.6	1.1	0.6	0.7	-0.1	-0.7	-0.4	1.0	1.2	1.3	0.2	-1.0	0.5
Glaucoma (self-reported)	2.0	2.3	5.5	-1.2	-1.4	-2.3	-1.3	-0.6	1.9	1.5	-1.5	-0.2	-1.6	-0.6	2.4	-1.6
Gout (self-reported)	0.4	0.5	2.0	-0.2	-0.9	-1.4	-0.5	0.2	0.6	0.6	-0.6	-0.2	-1.0	-0.1	-0.0	-1.1
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	7.5	-1.5	-1.8	-1.7	-2.0	-1.0	2.1	2.0	-2.0	-0.6	-2.7	-1.4	2.1	-2.3
Medication: Amlodipine	0.5	0.7	1.3	-1.0	-0.7	-0.9	-0.8	-0.9	1.0	0.8	-0.8	-0.6	-1.1	-0.1	0.9	-0.9
Medication: Ventolin 100micrograms inhaler	0.3	0.4	2.4	0.3	0.2	0.3	0.4	1.6	-0.4	-0.4	0.3	0.9	0.1	1.0	0.0	0.8
Birth weight	0.7	1.6	5.0	-1.5	-1.0	0.4	-1.4	-0.6	1.2	0.9	-1.4	-0.4	-0.9	-2.2	0.6	-1.9
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.3	-0.5	-0.6	-1.0	-0.5	1.1	0.3	0.7	-0.5	-0.1	-0.8	-0.4	-0.1	-0.5
High blood pressure (siblings)	0.5	0.7	2.4	-0.7	-0.8	-0.2	-0.8	-0.7	0.6	0.8	-1.1	-0.0	-0.4	-0.7	1.5	-1.1
Forced vital capacity (FVC), Best measure	0.2	0.8	2.0	0.0	-0.8	-1.2	-0.6	-1.4	0.7	0.6	-0.6	-1.4	-0.6	-1.0	1.0	-0.4
Body fat percentage	3.3	13.0	18.1	-4.2	-2.7	-3.6	-4.1	-2.7	4.3	2.8	-4.0	-3.1	-4.1	-3.7	3.5	-3.6
Leg fat percentage (right)	4.7	17.1	23.6	-4.7	-3.3	-4.6	-4.7	-3.0	4.9	3.7	-4.5	-3.4	-4.5	-3.5	4.3	-4.0
Arm fat-free mass (right)	2.7	13.7	20.7	-3.3	-3.3	-3.5	-3.9	-4.5	3.8	3.6	-4.0	-3.7	-3.9	-3.3	3.4	-3.6
Exposure to tobacco smoke outside home	2.2	2.9	4.1	-2.0	-1.4	-1.8	-2.0	-1.5	1.9	1.4	-1.9	-1.2	-1.8	-1.1	1.6	-2.0
Comparative body size at age 10	0.5	1.5	2.6	0.2	1.5	1.5	0.9	1.6	-1.1	-1.3	1.1	0.9	1.5	-0.2	-1.4	1.3
Number of full brothers	0.7	0.9	2.5	-1.0	-1.1	-0.8	-1.1	-1.6	0.9	0.7	-1.0	-0.9	-0.3	-0.2	1.5	-0.8
Worry too long after embarrassment	0.2	0.4	2.7	-0.6	-0.4	-0.2	-0.3	0.7	-0.0	0.4	-0.1	-1.6	-0.3	-1.0	0.2	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	3.0	3.8	10.5	-1.6	-1.9	-2.0	-1.6	-3.2	1.8	1.6	-1.9	-3.2	-1.8	-1.0	1.0	-1.5
Wheeze or whistling in the chest in last year	0.8	1.5	2.4	-1.2	-0.7	-1.5	-1.4	-1.2	1.5	-0.2	-1.4	-0.9	-1.6	-0.3	1.6	-1.4
Number of children fathered	0.2	0.2	0.8	0.3	0.9	0.4	0.4	-0.7	0.0	0.0	0.2	0.5	-0.4	-0.1	0.2	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.7	-0.5	-0.9	-1.0	-0.7	1.2	0.6	0.7	-0.2	-1.6	-0.5	-0.2	0.7	-0.4
Age at first live birth	3.8	6.7	15.0	2.3	2.6	3.9	2.8	1.7	-2.7	-2.4	2.5	1.9	3.0	1.1	-2.7	3.0
Pulse wave peak to peak time	0.3	0.3	1.4	-0.5	0.0	-0.3	-0.4	0.2	0.4	-0.1	-0.7	-0.1	-1.2	-0.3	0.8	-0.9
Health satisfaction	0.3	0.4	1.3	-0.5	-0.2	-0.5	-0.6	0.1	0.5	1.1	-0.7	-1.0	-0.9	-0.8	0.3	-0.4
Shortness of breath walking on level ground	2.7	3.3	5.8	-1.8	-2.4	-1.8	-2.2	-1.6	1.7	1.6	-1.9	-1.6	-1.4	-1.8	1.4	-2.0
Qualifications: College or University degree	2.9	9.0	12.9	2.8	3.2	3.4	3.6	1.9	-3.4	-2.8	3.2	2.2	3.0	3.1	-2.3	3.4
Eye problems/disorders: None of the above	1.3	1.5	7.8	0.6	0.2	0.9	0.6	0.9	-1.3	-1.5	0.8	1.3	1.0	0.6	-2.8	1.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.3	-0.5	-0.3	-1.3	-0.9	-0.8	1.1	0.5	-1.0	-0.4	-1.4	-0.6	1.5	-1.4
Emphysema/chronic bronchitis	0.5	0.5	1.2	-0.9	-0.5	-0.8	-0.7	-0.2	0.5	-0.3	-0.6	-1.0	-0.2	-1.1	0.6	-0.9
Medication for pain relief, constipation, heartburn	2.7	4.7	7.4	2.0	2.2	2.6	2.3	1.3	-2.7	-2.0	2.1	1.0	2.6	1.6	-2.3	2.5
Neck or shoulder pain in last month	1.7	2.4	5.2	-0.9	-1.2	-1.5	-1.0	-1.2	1.7	1.1	-1.6	-1.8	-1.9	-2.2	2.3	-1.3
Medication: Blood pressure	1.2	2.2	4.2	-1.4	-1.6	-1.3	-1.3	-1.1	1.3	1.6	-1.6	-2.1	-1.9	-1.0	1.5	-1.2
Angina (self-reported)	0.1	0.1	1.0	0.0	-0.2	-0.2	-0.1	-0.5	0.4	-0.1	0.2	-0.1	-0.3	0.2	1.0	-0.3
Migraine (self-reported)	0.1	0.2	1.3	-0.1	-0.1	-0.1	-0.2	-1.1	0.4	0.4	0.1	0.0	-0.2	0.6	0.2	0.0
Medication: Ibuprofen	0.1	0.1	0.3	0.5	0.4	-0.3	0.3	0.4	0.1	-0.2	0.2	0.5	-0.1	0.3	0.0	0.5
Medication: Allopurinol	0.1	0.1	1.0	0.0	0.1	-0.3	-0.0	0.2	-0.1	0.3	-0.3	-0.0	-0.3	0.3	-1.0	-0.3
Medication: Omeprazole	0.2	0.2	1.4	0.2	0.1	0.7	0.3	0.1	-0.1	0.2	0.5	1.2	0.0	-0.5	0.3	0.4
Medication: Seretide 50 evohaler	0.2	0.2	1.6	-0.3	0.3	0.1	-0.0	0.3	-0.0	-1.3	0.2	-0.8	-0.2	-0.2	-0.2	0.3
Mean time to correctly identify matches	0.5	0.9	1.7	-1.0	-0.3	-1.1	-0.9	0.3	1.3	0.4	-1.1	0.8	-0.4	-1.3	1.2	-1.0
Heart disease (mother)	0.2	0.3	1.1	0.6	0.2	0.4	0.1	-0.2	-0.4	-0.2	0.5	0.8	0.2	1.1	-0.8	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.5	0.9	1.1	0.8	1.3	-1.6	-1.1	0.4	1.0	-0.1	0.9	0.0	-0.2	1.3
Whole body fat mass	4.1	17.3	22.8	-4.6	-3.2	-4.0	-4.6	-3.6	4.8	3.5	-4.6	-3.9	-4.6	-4.2	3.9	-4.1
Leg fat mass (right)	5.0	19.3	25.7	-4.7	-3.5	-4.4	-4.8	-4.0	5.1	4.0	-4.9	-4.0	-4.7	-3.9	4.4	-4.4
Arm predicted mass (right)	2.6	13.5	20.2	-3.2	-3.3	-3.4	-3.8	-4.5	3.8	3.6	-3.9	-3.7	-4.0	-3.3	3.5	-3.6
Pulse rate, automated reading	0.9	3.1	6.2	-2.5	-1.1	-0.6	-1.7	-2.2	2.2	1.4	-1.8	-1.1	-1.5	-2.4	1.9	-1.1
Alcohol intake frequency.	1.1	2.6	5.6	-0.9	-2.4	-1.3	-1.6	-2.2	1.6	0.6	-1.9	-1.9	-1.9	-1.1	1.1	-1.4
Comparative height size at age 10	0.2	1.0	2.8	-0.3	0.2	0.1	-0.4	-1.6	0.7	1.0	-0.4	-1.5	-0.4	-1.7	1.6	-0.8
Number of full sisters	5.0	6.1	10.2	-2.5	-1.8	-2.5	-2.6	-1.3	2.8	2.4	-2.8	-2.3	-2.2	-2.4	3.2	-2.7
Suffer from ‘nerves’	0.1	0.2	0.8	-0.4	-0.3	-0.1	-0.1	0.5	0.1	-0.9	-0.2	-0.7	0.3	0.3	0.0	0.3
Overall health rating	1.2	2.6	4.0	-1.7	-1.6	-1.5	-1.7	-1.0	1.7	1.2	-1.8	-1.7	-2.0	-1.5	1.3	-1.9
Chest pain or discomfort	1.0	1.4	3.2	-1.1	-1.0	-1.8	-1.2	-1.2	1.4	0.5	-1.2	-1.3	-1.4	0.1	1.0	-1.2
Had major operations	1.3	1.6	5.2	0.7	1.3	1.2	1.0	-0.3	-1.1	-2.3	1.1	0.4	1.2	1.7	-1.6	0.9
Age at last live birth	1.2	1.8	6.2	0.8	0.8	2.5	1.3	1.2	-1.3	-0.7	1.1	1.1	2.0	-0.3	-1.4	1.3
Family relationship satisfaction	1.5	1.9	4.0	-1.4	-1.0	-2.0	-1.7	-1.1	1.6	0.7	-1.6	-1.4	-1.1	-0.8	1.7	-1.3
Leg pain on walking	1.0	1.2	2.6	1.0	1.4	1.6	1.1	0.9	-1.2	-1.2	1.0	0.5	1.3	0.8	-0.9	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	3.2	-1.3	-0.5	-0.1	-0.9	-0.3	0.9	1.0	-0.6	-1.5	-1.8	-1.7	0.4	-0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.8	0.7	1.4	1.7	1.0	1.5	-1.1	-1.0	1.2	0.9	0.9	0.1	-0.0	1.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	0.6	-0.5	0.6	0.3	-0.2	-0.2	-0.7	0.5	0.8	-0.3	-0.1	-0.7	0.5
Medication: Aspirin	0.2	0.2	0.9	0.2	-0.2	-0.3	-0.1	0.8	0.1	0.4	0.3	0.5	-0.9	0.9	-0.2	-0.3
Supplements: Vitamin C	0.3	0.4	0.9	0.5	0.8	0.7	0.6	-0.3	-0.3	-0.6	1.0	0.5	0.6	0.5	0.1	0.7
Knee pain experienced in last month	0.4	0.6	3.3	0.3	0.9	0.7	0.4	1.8	-0.5	-0.9	0.6	0.9	0.3	0.5	-0.4	0.7
Hypertension (Self-reported)	0.8	2.1	3.9	-1.4	-1.4	-1.1	-1.4	-1.2	1.5	1.6	-1.5	-1.7	-2.0	-0.8	1.9	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.3	-0.4	-0.4	-0.1	-0.0	-0.9	0.0	1.1	-0.1	-0.4	-0.1	0.4	0.3	0.4
Illnesses of father: Heart disease	0.3	0.4	1.5	-0.6	-1.2	-0.6	-0.6	-0.6	0.4	0.2	-0.1	-0.7	-0.6	-0.6	0.7	-0.8
Illnesses of siblings: Diabetes	0.1	0.2	0.6	-0.7	0.4	-0.4	-0.4	0.8	0.3	-0.3	-0.1	0.1	0.4	0.6	0.4	-0.1
Smoking status: Previous	1.1	1.6	3.4	-1.4	-0.7	-1.1	-1.2	-1.2	1.2	1.4	-1.4	-1.6	-1.2	-1.8	0.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.6	0.1	0.2	-0.1	-0.2	-1.0	0.0	-0.3	-0.2	-1.3	-0.6	-0.7	-0.2	-0.5
Whole body fat-free mass	1.6	9.0	17.2	-2.5	-2.5	-2.6	-3.0	-4.2	3.0	2.9	-3.3	-3.1	-3.1	-2.8	2.6	-2.9
Leg fat-free mass (right)	1.5	8.2	16.7	-2.8	-2.4	-2.1	-3.0	-4.1	2.9	2.5	-3.4	-2.9	-3.0	-2.9	2.1	-2.7
Arm fat percentage (left)	1.9	7.7	11.6	-3.4	-1.8	-2.6	-3.1	-2.0	3.4	2.2	-3.2	-2.0	-3.4	-2.9	2.6	-2.7
Average weekly red wine intake	4.6	6.7	11.9	1.8	2.9	2.5	2.6	2.6	-2.6	-1.9	2.7	3.3	2.3	1.5	-3.4	2.7
Handedness (chirality/laterality): Left-handed	1.5	1.7	3.5	-1.1	-1.8	-1.4	-1.5	-0.8	1.4	0.2	-1.4	-1.0	-1.1	-1.1	1.9	-1.7
Mood swings	2.7	4.8	10.7	-2.5	-2.1	-3.3	-2.5	-1.5	2.0	1.9	-2.5	-2.1	-2.3	-1.3	1.4	-2.2
Loneliness, isolation	2.2	3.1	6.7	-1.5	-2.2	-1.7	-2.0	-1.2	1.7	1.0	-2.2	-2.6	-1.7	-0.8	1.2	-2.1
Long-standing illness, disability or infirmity	2.4	3.7	6.1	-1.9	-1.8	-2.3	-2.0	-0.0	2.4	0.8	-1.9	-2.3	-2.5	-1.8	1.9	-1.7
Ever had bowel cancer screening	1.4	1.6	3.0	-1.2	-1.6	-1.7	-1.5	-1.1	1.4	1.5	-1.2	-0.4	-1.4	-0.4	0.9	-1.4
Diabetes diagnosed by doctor	0.1	0.1	0.3	0.5	0.1	0.2	0.1	-0.3	-0.2	-0.6	-0.1	-0.3	-0.3	0.6	0.2	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.6	0.9	0.7	0.3	0.8	0.2	-0.6	-0.3	0.5	0.8	1.3	-0.2	0.4	-0.0
Friendships satisfaction	0.2	0.2	0.7	0.2	0.8	0.6	0.1	0.8	-0.2	-0.7	0.1	0.2	-0.2	0.5	0.1	0.4
Qualifications: nursing, teaching	0.6	0.9	1.8	0.9	0.9	1.2	0.9	-0.4	-1.3	-0.5	1.1	0.1	1.1	0.5	-1.1	1.2
Commuting to job workplace: Walk	0.3	0.3	1.1	0.1	-0.7	-0.2	-0.0	-0.7	-0.1	1.0	-0.1	0.2	-0.2	-0.6	-1.0	-0.3
Eye problems/disorders: Cataract	0.3	0.3	1.0	0.6	0.7	1.0	0.5	0.7	-0.3	0.1	0.4	0.5	0.5	0.2	0.7	0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	2.5	-1.2	-1.4	-1.6	-1.5	-1.3	1.3	1.4	-1.1	-1.4	-1.2	-0.9	1.4	-1.5
Medication for cholesterol	0.2	0.3	2.0	0.6	-0.0	0.4	0.2	1.4	-0.1	-0.2	0.5	0.7	0.7	-0.5	0.0	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.1	-0.1	-0.1	-0.7	-0.5	-0.6	0.8	-0.5	-0.8	-0.6	-1.0	1.1	0.3	-0.6
Back pain experienced in last month	2.6	3.8	12.0	-1.4	-1.6	-2.0	-1.7	-2.3	1.9	1.1	-1.9	-3.5	-2.4	-1.3	1.8	-1.1
Mineral and other dietary supplements	0.6	0.8	1.6	0.8	1.0	1.0	0.6	1.3	-0.5	-1.2	0.4	1.2	0.4	1.2	-0.5	0.5
Breast cancer (self-reported)	0.2	0.2	1.3	-0.6	-0.4	-0.0	-0.2	0.1	0.5	0.5	-0.5	-0.6	-0.2	-0.3	1.2	0.1
Asthma (self-reported)	0.1	0.1	0.9	0.0	0.2	0.4	0.1	-0.5	-0.1	-1.0	0.1	0.1	-0.1	0.6	-0.1	0.3
Osteoporosis (self-reported)	1.3	1.7	6.2	1.1	0.8	1.5	1.1	2.5	-1.0	-1.4	1.3	1.7	0.9	0.3	-0.8	1.1
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.7	0.8	0.3	0.7	0.7	-0.8	-0.8	0.9	0.5	1.0	0.6	-0.9	0.6
Medication: Aspirin	0.2	0.2	1.1	0.5	0.0	-0.1	0.1	0.6	-0.2	0.2	0.6	0.3	-0.6	1.1	-0.4	0.0
Medication: Gliclazide	1.0	1.2	2.6	-1.1	-1.4	-0.3	-1.1	-1.6	0.7	1.3	-1.2	-1.6	-1.2	-0.4	-0.0	-0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.5	0.9	1.0	-0.0	0.7	1.2	-0.3	-0.5	0.3	0.7	-0.2	0.9	-0.3	0.9
Smoking status: Current	1.0	1.7	3.2	-0.8	-1.2	-1.2	-1.3	-1.7	1.5	0.9	-1.4	-1.1	-1.4	-0.4	1.4	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.4	9.3	-0.6	-2.3	-3.0	-1.5	-1.5	1.8	2.8	-1.7	-2.6	-2.2	-1.3	2.8	-1.6
Whole body water mass	1.5	8.6	17.0	-2.5	-2.4	-2.6	-3.0	-4.1	2.9	2.9	-3.3	-3.1	-3.0	-2.7	2.5	-2.8
Leg predicted mass (right)	1.5	8.3	16.6	-2.8	-2.4	-2.1	-2.9	-4.1	2.9	2.5	-3.4	-2.9	-3.0	-3.0	2.1	-2.7
Arm fat mass (left)	3.2	13.1	17.6	-4.0	-2.7	-3.5	-4.0	-3.3	4.2	3.2	-4.1	-3.2	-4.1	-3.5	3.3	-3.6
Number of self-reported non-cancer illnesses	1.6	2.7	5.3	-1.5	-1.7	-1.7	-1.8	-1.6	2.0	0.7	-1.6	-1.6	-2.3	0.1	2.0	-1.6
Average weekly champagne plus white wine intake	0.9	1.3	2.5	1.2	1.1	1.0	1.0	1.6	-1.2	-1.4	1.2	1.6	0.9	0.6	-0.7	0.4
Miserableness	1.2	2.2	6.2	-1.5	-1.3	-2.5	-1.5	-0.5	1.0	1.5	-1.6	-2.3	-1.0	-0.7	0.9	-1.3
Guilty feelings	0.9	1.3	3.4	-0.9	-1.8	-1.0	-1.1	0.3	1.1	1.3	-1.0	-1.6	-0.7	-0.6	1.5	-0.7
Wears glasses or contact lenses	0.2	0.2	0.8	-0.3	-0.6	0.4	-0.3	-0.9	0.1	-0.6	-0.1	-0.6	0.2	0.5	0.0	-0.1
Ever taken oral contraceptive pill	1.3	1.5	3.8	1.3	2.0	1.8	1.4	0.6	-1.1	-1.3	1.1	0.9	0.8	0.7	-0.7	1.3
Hearing aid user	0.2	0.3	0.9	0.4	0.7	0.1	0.3	0.9	-0.3	-0.9	0.2	-0.0	0.7	0.3	-0.5	0.5
Mother’s age at death	0.5	0.6	1.9	0.6	1.4	1.0	0.7	1.1	-0.6	-0.2	0.4	1.2	0.5	0.6	-0.7	0.5
Financial situation satisfaction	1.5	1.8	4.0	-1.0	-1.5	-1.9	-1.3	-1.1	1.2	2.0	-1.7	-0.5	-1.2	-0.9	1.0	-1.3
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.9	-0.3	-0.1	-0.5	-0.4	0.8	0.3	0.2	-0.5	0.3	-0.4	-0.9	0.7	-0.5
Commuting to job workplace: Public transport	1.2	1.4	5.3	1.4	0.5	0.7	1.3	0.8	-1.1	-2.3	0.6	0.8	0.5	1.3	-1.3	1.3
Eye problems/disorders: Glaucoma	0.9	1.0	3.2	-0.7	-0.9	-1.3	-0.6	-0.7	1.0	1.8	-1.1	-0.3	-0.8	0.2	1.6	-0.9
Medication: Blood pressure	0.2	0.3	1.1	-0.7	-0.5	-0.1	-0.5	0.2	0.5	0.1	-0.6	-0.1	-1.0	1.0	0.7	-0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.9	-0.7	-0.4	0.0	-0.3	-0.9	0.7	-0.1	-1.0	-0.5	-0.6	-0.2	0.7	-0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.0	-1.4	-1.3	-1.0	-1.1	-1.1	0.8	1.4	-0.9	-2.0	-0.4	-1.1	0.5	-0.8
High cholesterol (Self-reported)	0.3	0.5	2.0	-0.5	-0.2	-1.1	-0.5	0.5	0.5	1.4	-0.3	-0.5	-0.9	-0.2	0.4	-0.6
Medication: Bendroflumethiazide	2.1	3.2	10.0	-2.0	-1.5	-1.4	-1.7	-2.4	1.4	1.8	-2.0	-3.2	-1.4	-1.2	0.6	-1.5
Medication: Paracetamol	0.4	0.6	1.2	-0.8	-0.6	-0.8	-0.8	-0.9	1.0	1.0	-0.6	-0.5	-0.6	-0.4	1.1	-0.9
Medication: Lisinopril	0.0	0.1	0.2	-0.1	-0.5	-0.2	-0.3	0.1	0.0	-0.2	-0.1	0.3	-0.1	0.2	0.4	-0.3
Medication: Atorvastatin	0.1	0.2	0.6	0.3	0.8	0.6	0.4	-0.3	-0.3	0.2	0.2	-0.6	0.2	0.6	-0.2	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.2	-0.2	0.4	0.4	0.5	-0.9	-0.7	0.3	0.0	0.5	0.8	-0.8	0.1
Alcohol drinker status: Never	0.2	0.3	1.4	0.2	-0.1	-0.3	-0.2	-0.8	0.6	0.4	-0.1	-0.6	-1.2	-0.4	0.1	-0.1
Ever smoked	2.2	3.8	5.5	-2.0	-1.5	-1.5	-1.9	-2.3	2.0	1.8	-2.3	-2.2	-1.5	-2.2	1.6	-2.4
Basal metabolic rate	2.1	11.4	19.5	-3.1	-2.8	-3.0	-3.5	-4.4	3.5	3.2	-3.8	-3.5	-3.5	-3.2	2.9	-3.3
Leg fat percentage (left)	5.2	18.7	25.8	-5.1	-3.6	-4.8	-5.0	-3.1	5.1	3.5	-4.7	-3.5	-4.9	-3.8	4.3	-4.2
Arm fat-free mass (left)	2.7	13.8	23.3	-3.2	-3.2	-3.7	-3.8	-4.8	3.8	3.4	-4.0	-3.9	-3.8	-3.2	3.5	-3.5
Number of operations (self-reported)	0.6	0.9	1.7	0.7	0.8	1.2	0.9	-1.3	-0.8	-1.1	0.8	0.7	1.3	1.0	-0.7	0.5
Average weekly beer plus cider intake	1.4	2.0	4.7	-1.0	-1.3	-1.5	-1.5	-1.3	1.5	1.4	-1.3	-1.6	-0.9	-1.2	2.2	-1.4
Irritability	3.7	6.3	9.8	-2.9	-2.5	-2.9	-2.7	-1.7	2.8	1.1	-3.0	-3.1	-3.1	-1.4	2.0	-2.5
Risk taking	0.3	0.4	2.1	0.3	-0.1	-0.1	0.4	-0.3	-0.1	-1.5	0.2	0.7	-0.1	1.4	0.1	0.7
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.3	0.3	0.4	0.2	0.5	-0.1	-0.3	0.7	-0.3	-0.3	0.1	-0.0	0.4
Fractured/broken bones in last 5 years	0.6	0.8	1.6	0.8	1.2	0.8	1.0	0.9	-0.8	0.3	1.1	1.2	0.8	0.6	0.1	0.9
Age started oral contraceptive pill	1.5	1.9	5.3	1.2	1.2	0.6	1.4	1.7	-1.0	-1.7	1.9	2.3	0.5	1.2	-0.9	1.3
Diastolic blood pressure, automated reading	2.9	9.0	14.4	-3.1	-2.6	-2.6	-3.2	-0.6	3.4	3.0	-3.0	-3.8	-3.3	-3.6	3.1	-2.4
Ever depressed for a whole week	2.1	2.6	5.6	-1.1	-1.6	-1.8	-1.3	-2.1	1.4	1.8	-1.1	-2.4	-1.7	-1.8	1.2	-1.1
Unable to work because of sickness or disability	0.5	0.7	2.6	-0.9	-0.3	-0.4	-0.6	-1.0	1.0	0.4	-1.0	-1.0	-0.6	0.0	1.6	-0.6
Commuting to job workplace: Cycle	0.2	0.2	1.3	-0.0	0.2	0.3	0.3	-0.2	-0.3	0.5	0.2	0.2	-0.0	1.1	-0.7	0.7
Myopia	0.4	0.6	1.4	-0.8	-1.1	-0.9	-0.9	-0.2	1.2	-0.1	-0.9	-0.1	-1.2	-0.2	0.7	-0.4
Vascular/heart problems diagnosed by doctor	1.0	2.7	6.5	1.5	1.3	1.2	1.6	1.3	-1.7	-1.3	1.6	1.8	2.4	0.9	-2.5	1.4
Cholesterol lowering medication	0.4	0.6	1.7	-0.6	-1.0	-1.1	-0.8	-1.0	0.6	-0.3	-0.4	-0.9	-1.3	0.5	0.7	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.9	-0.0	-0.1	0.1	0.1	-0.5	0.1	0.4	0.4	1.0	-0.1	-0.3	0.6	0.1
Pain experienced in last month	2.7	4.6	8.2	1.8	1.9	2.2	2.0	1.6	-2.5	-1.1	2.5	2.8	2.1	2.2	-2.9	1.7
Supplements: Calcium	4.9	5.4	7.5	2.3	2.4	2.4	2.3	2.1	-2.3	-2.6	2.6	2.7	2.5	2.0	-1.3	2.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	-0.6	0.4	-0.2	-0.3	-0.1	0.4	0.3	-0.3	-0.5	-0.2	-0.9	0.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.2	-0.4	-0.3	-0.3	-0.9	-0.8	0.5	0.6	-0.6	-1.1	-1.5	-0.2	1.2	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.1	1.8	1.0	0.7	1.0	1.1	-1.0	-1.3	0.9	1.1	1.0	1.0	-0.0	0.8
Heart disease (siblings)	0.6	0.7	3.1	-0.9	-0.1	-1.1	-1.0	-1.8	0.7	0.7	-0.5	0.3	-0.5	0.1	1.0	-0.9
Alcohol drinker status: Previous	0.1	0.1	0.4	0.2	-0.2	0.0	0.2	0.3	-0.1	0.3	0.1	0.7	-0.3	-0.3	0.5	-0.2
Pack years of smoking	0.4	0.6	1.8	-0.2	-0.8	-1.0	-0.5	-0.4	0.6	1.0	-0.5	-1.3	-0.6	-0.4	1.1	-0.7
Impedance of whole body	1.0	4.9	8.0	1.9	2.2	2.0	2.3	2.8	-2.2	-2.4	2.8	2.2	2.3	1.6	-1.6	1.9
Leg fat mass (left)	5.6	22.0	28.7	-5.1	-3.9	-4.8	-5.2	-4.2	5.4	4.1	-5.2	-4.2	-5.2	-4.2	4.5	-4.7
Arm predicted mass (left)	2.9	14.8	22.4	-3.4	-3.4	-3.9	-4.0	-4.7	3.9	3.5	-4.2	-4.1	-4.1	-3.4	3.5	-3.7