Hub : Genes

NBPF10

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0990	0.0440	2.7e-03	-0.001	0.017	0.010	0.018	0.001	5.6e-01	3.0e-03	1.8e-02	2.7e-03	2.3e-01
2	GTEx	Adipose Subcutaneous	0.0590	0.0310	1.9e-03	0.014	NA	0.015	NA	0.029	2.3e-02	NA	1.9e-02	NA	2.0e-03
3	METSIM	Adipose	0.0857	0.0321	7.0e-10	0.047	0.078	0.090	0.079	0.086	1.5e-07	9.9e-12	2.5e-13	6.1e-12	7.5e-13
4	YFS	Blood	0.0790	0.0286	1.2e-05	0.018	0.021	0.022	0.027	0.019	8.1e-07	1.7e-07	6.6e-08	2.4e-09	4.7e-07
5	TCGA	Brain Lower Grade Glioma	0.0687	0.0310	3.4e-04	0.043	0.019	0.021	NA	0.026	1.0e-05	2.6e-03	1.6e-03	NA	4.9e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.5	0.8	1.4	0.5	1.1	1.2	1.1	0.3
Bipolar Disorder or Schizophrenia	0.9	2.3	6.2	-1.1	1.4	1.2	2.5	1.0
Depressed Affect (Nagel 2018)	2.2	4.6	10.0	2.1	3.2	1.8	-0.3	2.3
Depression (Nagel 2018)	3.1	4.7	10.4	3.2	2.8	0.9	0.8	1.9
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.9	-0.1	-1.1	-1.7	-0.0	0.4
Neuroticism (Nagel 2018)	1.5	3.5	8.1	1.8	2.8	1.5	0.8	1.9
Schizophrenia (2018)	1.2	2.4	6.2	-1.5	1.2	0.9	2.5	1.1
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	-0.4	0.8	-0.3	0.3	-0.1
Worry (Nagel 2018)	0.6	1.2	4.1	0.2	2.0	0.9	0.9	0.4
Alzheimer’s Disease (in mother)	1.4	1.6	6.1	1.3	-0.3	-0.2	-0.2	2.5
Alzheimer’s Disease (in father)	0.7	0.8	2.6	0.3	0.5	0.9	0.7	1.6
Alzheimer’s Disease (including proxy)	1.1	1.6	6.8	0.9	0.2	-0.1	0.4	2.6
Crohns Disease (2017)	0.8	1.7	3.7	-1.9	-1.2	-1.5	-0.5	-0.9
Irritable Bowel Disease (IBD)	1.9	4.5	7.0	-2.6	-2.6	-1.8	-1.1	-2.2
Ulcerative Colitis (UC)	2.2	4.1	7.8	-1.8	-2.8	-1.4	-1.2	-2.4
Major Depression (MDD)	0.4	0.5	2.5	1.6	0.0	0.0	0.0	0.0
Reaction Time	1.7	3.2	7.1	0.9	1.4	1.4	2.1	2.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.4	0.4	-1.0	-1.1	-1.6	-0.1
Breast Cancer	7.4	17.9	29.4	3.7	5.4	5.2	1.3	4.2
Ovarian Cancer	1.6	2.1	7.4	-2.7	-0.5	-1.3	-0.1	-1.1
Prostate Cancer	0.6	0.9	3.7	0.2	0.8	0.1	0.0	1.9
Age at First Birth	0.8	1.1	5.0	0.8	-0.1	2.2	-0.2	0.1
Bipolar Disorder (2011)	0.2	0.2	1.0	1.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	3.9	0.3	-2.0	-1.5	-0.2	-0.4
Coronary Artery Disease (CAD)	0.3	0.3	0.9	-1.0	0.2	-0.4	0.2	0.7
Crohns Disease (2012)	0.7	1.1	4.0	-2.0	-0.7	-0.9	-0.4	0.2
Mean Putamen Volume	0.9	1.0	2.3	-0.2	-1.1	-0.8	-1.5	-0.9
Fasting Glucose	1.6	1.9	5.6	-0.2	-1.9	-2.4	0.1	-0.2
HbA1C	0.3	0.4	0.9	-0.4	-0.3	-0.6	-0.6	-0.9
HDL Cholesterol	2.3	3.8	9.5	0.8	2.6	3.1	0.1	1.3
LDL Cholesterol	1.1	1.7	4.1	0.2	-2.0	-2.0	0.1	-0.7
Lupus	0.5	0.8	2.2	0.1	-1.5	-0.6	-0.9	-0.8
Neuroticism (2016)	1.4	2.0	5.5	2.4	1.6	1.1	0.9	0.3
Primary Biliary Cirrhosis	1.7	2.4	8.4	1.4	1.2	0.5	-0.3	2.9
Rheumatoid Arthritis	0.4	0.5	1.7	0.2	0.4	-0.2	-0.7	1.3
Schizophrenia (2014)	0.8	1.8	4.9	-0.4	1.1	1.1	2.2	1.3
Triglycerides	4.6	7.6	16.7	0.5	-3.6	-4.1	0.9	-2.7
Type 2 Diabetes (T2D) (2012)	1.1	1.2	3.5	0.3	-1.3	-1.9	-0.2	-0.9
Ulcerative Colitis	0.9	1.3	2.8	-1.2	-1.7	-0.2	-0.9	-1.2
Blood Eosinophil Count	0.1	0.6	1.4	1.2	-0.4	-0.1	0.1	1.1
Blood Platelet Count	0.6	7.1	16.6	-4.1	-1.3	-4.0	-0.3	-1.1
Blood Red Count	0.5	4.5	10.4	1.7	3.2	1.8	0.1	2.4
Blood White Count	0.3	2.5	5.7	-1.2	-0.9	-2.1	-2.4	0.1
Heel T-Score	0.2	1.2	2.0	1.2	-1.0	-0.8	1.0	1.4
BMI	0.6	3.4	6.7	2.6	-0.7	-2.3	2.1	0.7
Height	0.0	0.3	0.9	0.2	-0.2	0.3	-0.9	-0.7
Waist Hip Ratio (WHR)	0.4	1.8	5.9	-2.4	0.9	0.4	-0.1	1.6
Systolic Blood Pressure	1.4	7.0	11.0	-2.4	-2.6	-3.3	-0.8	-3.3
Smoking Status	1.1	2.6	4.7	-0.9	-1.7	-0.6	-2.0	-2.2
Allergy or Eczema	0.4	1.2	3.3	1.8	1.0	0.9	-0.8	-0.4
Cardiovascular Disease	0.9	2.9	9.0	-1.1	-1.2	-3.0	1.3	-1.1
Hypothyroidism (self reported)	0.7	1.6	3.0	-1.0	-1.3	-1.7	-0.0	-1.6
Respiratory disease	0.6	1.3	3.2	1.4	-0.7	-0.9	0.5	-1.8
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	0.7	0.8	0.2	-0.8	0.5
Lung FEV1/FVC ratio	0.3	1.5	3.0	-1.7	1.2	0.1	1.5	0.8
Lung FVC	0.8	3.9	7.6	-2.8	-1.6	-1.8	-0.2	-2.5
Neuroticism	1.0	2.5	6.3	1.6	2.5	1.7	-0.1	0.9
Chronotype (morning person)	0.4	1.0	1.9	0.7	-0.9	-1.4	1.3	-0.4
Hair Pigment	0.0	0.4	1.3	1.1	0.3	-0.5	0.5	-0.0
Tanning	0.0	0.2	0.6	-0.5	-0.2	-0.8	0.1	0.3
Hand grip strength (left)	0.6	1.6	2.4	-1.5	-0.5	-1.6	-1.3	-1.3
Number of treatments/medications taken	1.3	2.4	4.9	1.7	-1.5	-2.2	1.4	-0.3
Average weekly spirits intake	0.4	0.5	1.4	0.4	0.5	1.2	0.6	0.5
Sensitivity / hurt feelings	0.7	1.1	4.7	2.2	0.7	0.1	0.6	0.5
Frequency of depressed mood in last 2 weeks	1.9	2.6	8.6	2.9	1.6	0.3	0.1	1.4
Hearing difficulty/problems: Yes	2.0	3.1	7.7	2.4	1.2	0.5	2.8	0.5
Relative age of first facial hair	1.9	3.8	7.5	0.1	1.9	2.7	-2.4	1.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.1	0.5	-1.1	-0.9	-0.4	-0.8
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.0	0.3	-0.8	-0.2	1.4	-1.7
Ever had hysterectomy (womb removed)	0.8	0.9	1.3	1.1	-0.8	-1.1	1.1	-0.2
Systolic blood pressure, automated reading	1.8	5.1	15.1	-1.4	-2.4	-3.9	0.8	-1.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	0.5	0.6	-0.1	1.1	0.3
Angina	1.2	1.6	3.6	1.1	-0.4	-0.3	1.7	1.9
Medication for hormone replacement therapy	1.4	1.5	4.4	-0.9	-0.5	0.8	-1.2	-2.1
Vitamin and mineral supplements	0.7	0.9	3.0	0.5	-0.1	-0.8	0.9	1.7
Supplements: Zinc	1.2	1.4	3.2	-0.1	-0.8	0.4	-1.8	-1.7
Medication: Co-codamol	0.7	0.8	1.4	1.2	0.1	-0.2	0.9	1.2
Medication: Metformin	1.2	1.7	3.9	2.0	1.3	-0.2	0.2	1.7
Diabetes (father)	0.9	1.1	2.0	-1.1	0.8	1.4	0.7	-1.0
Diabetes (mother)	1.1	1.4	3.2	-1.3	-0.9	0.3	-1.8	-1.2
Severe depression (siblings)	1.5	1.6	4.7	1.4	-0.5	-1.2	2.2	-0.3
Pack years adult smoking proportion	0.7	1.1	2.6	1.1	1.6	0.4	0.0	1.3
Impedance of leg (right)	0.2	0.9	1.9	-0.9	0.8	0.8	-1.4	0.5
Leg fat-free mass (left)	0.1	0.4	1.2	1.1	0.1	-0.5	0.6	-0.3
Trunk fat percentage	1.4	5.4	11.9	1.3	-1.3	-3.4	3.1	1.6
Hand grip strength (right)	0.5	1.2	3.0	-1.0	-0.6	-1.7	-0.7	-1.2
Townsend deprivation index at recruitment	1.0	1.4	2.3	-0.1	-1.5	-1.1	-1.4	-1.3
Current tobacco smoking	0.8	1.4	3.5	0.0	-1.9	-1.6	-0.2	-0.8
Average weekly fortified wine intake	0.7	0.8	2.3	0.1	-1.5	-1.0	-0.4	-0.7
Maternal smoking around birth	0.8	1.2	2.6	0.8	-0.8	-1.6	1.4	-0.4
Fed-up feelings	1.7	3.2	6.6	1.7	2.6	1.2	-1.0	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	2.8	1.7	1.0	-0.4	1.6	0.1
Relative age voice broke	1.2	1.8	4.6	0.2	2.0	2.2	-0.2	0.7
Taking other prescription medications	1.4	2.2	4.1	1.6	-1.4	-2.0	1.5	-0.0
Age when periods started (menarche)	0.5	1.2	4.0	-2.0	-1.1	-0.2	-0.7	-0.6
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	5.6	2.4	1.4	0.5	1.1	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	3.3	0.8	-1.2	-1.1	-1.8	-0.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.2	-0.7	-1.5	-1.4	-0.2	-1.1
Qualifications: CSEs or equivalent	0.4	0.6	0.9	-0.4	0.9	0.9	-1.0	-0.2
Serious illness, injury or assault to yourself	0.7	0.8	3.2	1.8	0.3	-0.1	-0.1	0.9
High blood pressure	0.9	2.4	5.4	-0.7	-1.2	-2.3	1.6	-1.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.9	0.9	0.9	1.2	-1.7	-0.5
Multivitamins +/- minerals	0.2	0.3	0.6	-0.7	0.3	-0.1	0.6	-0.8
Stomach or abdominal pain in last month	0.3	0.4	1.2	0.5	0.1	-0.3	1.1	0.5
Supplements: Glucosamine	1.1	1.4	3.7	-0.6	-1.4	-1.0	-0.2	-1.9
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.6	0.8	1.6	1.1	0.8	1.6
Medication: Atenolol	0.9	1.1	2.9	-0.5	-0.2	-1.4	1.7	0.7
Medication: Levothyroxine sodium	0.6	1.0	2.0	-0.8	-1.0	-1.4	0.7	-1.0
Sitting height	0.2	1.7	4.3	-1.2	0.1	0.7	-1.4	-2.1
Chronic bronchitis/emphysema (father)	1.1	1.3	3.0	1.7	0.3	-0.4	1.4	1.2
High blood pressure (mother)	1.8	2.5	6.1	-0.1	-2.3	-2.5	0.1	-1.0
Body mass index (BMI)	1.0	4.1	8.5	1.5	-1.1	-2.9	2.9	0.5
Impedance of leg (left)	0.2	1.2	2.9	-1.7	0.1	0.2	-1.7	0.2
Leg predicted mass (left)	0.1	0.3	1.0	1.0	0.1	-0.5	0.6	-0.4
Trunk fat mass	1.1	4.5	9.2	1.8	-0.9	-3.0	2.7	1.4
Waist circumference	0.8	2.9	5.6	1.3	-0.8	-2.4	2.2	1.2
Number of incorrect matches in round	0.3	0.5	1.7	0.2	0.3	-0.7	0.1	1.3
Past tobacco smoking	0.8	1.5	3.0	0.3	1.7	0.6	1.1	1.6
Alcohol usually taken with meals	0.1	0.2	0.6	0.7	0.5	0.2	0.3	-0.1
Nervous feelings	0.2	0.4	0.7	0.4	0.8	0.5	0.8	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	0.5	0.6	-0.4	-0.0	-0.4
Hearing difficulty/problems with background noise	1.9	3.1	8.5	2.0	1.3	1.1	2.9	0.3
Hair/balding pattern: Pattern 2	0.5	0.6	1.2	0.4	-1.0	-0.7	-0.5	-1.1
Had menopause	0.8	1.0	4.5	-0.4	-0.4	-0.1	2.1	-0.1
Had other major operations	2.9	3.5	9.8	2.4	-0.4	-1.0	3.1	1.0
Forced vital capacity (FVC)	1.1	4.3	9.9	-2.4	-0.8	-0.5	-2.2	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.4	1.8	-0.3	-0.2	-1.8	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	0.5	0.3	-0.5	0.2	0.9
Qualifications: None of the above	1.6	3.4	6.7	0.7	-1.5	-2.6	2.5	1.1
Financial difficulties in last 2 years	1.0	1.4	2.8	-0.5	1.3	1.7	-1.2	0.9
Mouth/teeth dental problems	0.8	1.2	2.9	-1.7	-0.6	-0.2	-1.4	-1.0
Heart attack	0.2	0.2	0.4	-0.6	0.3	0.5	0.5	0.3
Allergy	0.5	1.2	2.5	-1.6	-1.3	-1.2	0.1	0.6
Pain all over the body in last month	1.4	1.5	2.8	0.8	1.3	1.4	-1.7	0.5
Diabetes (self-reported)	0.5	0.8	1.8	1.3	1.3	0.6	-0.5	0.6
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	2.7	0.3	0.2	0.3	-1.6	-0.0
Medication: Ramipril	0.2	0.3	0.5	0.5	-0.0	0.1	0.7	0.7
Medication: Simvastatin	1.2	1.8	2.7	1.5	1.6	1.1	0.4	1.6
Fluid intelligence score	0.2	0.4	0.9	1.0	-0.5	-0.5	-0.8	-0.4
Illnesses of siblings	3.1	4.4	10.2	-0.2	2.9	3.2	-1.6	0.8
Neuroticism score	0.6	1.2	2.8	1.7	1.5	0.6	0.3	0.7
Weight	0.5	2.4	5.4	1.5	-0.7	-2.3	1.9	0.4
Impedance of arm (right)	0.2	1.0	1.5	-1.2	0.4	1.0	-1.0	1.1
Arm fat percentage (right)	1.2	4.6	8.9	1.4	-1.0	-3.0	3.0	1.4
Trunk fat-free mass	0.1	0.4	1.1	1.1	0.2	-0.3	0.1	-0.9
Hip circumference	0.8	3.3	5.9	2.1	-0.8	-2.4	2.2	0.9
Time employed in main current job	0.6	0.7	1.4	-0.8	-0.7	-0.9	1.2	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.9	0.1	-0.5	-0.3	-0.9	-0.3
Father’s age at death	0.1	0.2	0.3	-0.5	0.4	0.3	-0.3	-0.6
Worrier / anxious feelings	0.5	1.0	2.8	-0.9	-0.7	-0.8	-0.2	-1.7
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	6.4	2.5	0.1	-1.0	1.1	1.8
Falls in the last year	2.5	3.4	11.3	3.4	0.8	-1.1	1.9	0.0
Hair/balding pattern: Pattern 3	0.6	0.8	2.0	0.3	1.2	1.4	-0.1	0.8
Number of live births	1.8	2.6	4.6	-2.1	-1.6	-1.4	0.3	-2.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	9.6	-2.7	-0.4	-0.4	-1.8	-3.1
Pulse rate	0.4	0.7	1.9	-0.1	0.3	-0.8	-1.4	1.0
Happiness	0.8	0.9	1.5	1.0	1.1	0.4	1.2	0.9
Noisy workplace	0.3	0.3	1.0	-0.4	-1.0	-0.6	-0.3	0.0
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.2	0.2	1.5	2.0	-1.4	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	1.0	-0.0	-0.2	-0.4	-0.3
Mouth/teeth dental problems: Dentures	2.2	3.8	8.8	1.8	-1.5	-2.0	3.0	0.6
Asthma	0.7	1.4	2.3	1.2	-1.0	-1.5	0.4	-1.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.8	0.5	-0.2	-0.3	-1.7	0.2
Medication: Cholesterol lowering	1.8	2.9	4.1	2.0	1.9	1.4	0.6	2.0
Depression (self-reported)	0.6	0.7	1.5	1.0	0.6	-0.8	1.2	0.1
Medication: Lansoprazole	0.3	0.4	1.4	0.2	0.4	0.3	1.2	0.4
Prospective memory result	2.0	2.4	4.8	0.6	2.1	2.2	0.5	1.5
Lung cancer (father)	1.0	1.2	2.7	1.4	-0.2	-0.1	1.1	1.6
Illnesses of mother	2.5	3.1	7.6	-0.7	2.8	2.5	-1.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	3.0	6.7	-2.4	-0.2	-0.4	-1.6	-2.6
Pulse wave Arterial Stiffness index	1.2	1.4	5.1	0.9	0.6	-0.6	-0.7	2.3
Impedance of arm (left)	0.2	0.8	2.0	-0.8	0.7	0.7	-0.8	1.4
Arm fat mass (right)	0.9	3.7	8.2	1.3	-1.0	-2.9	2.7	0.7
Trunk predicted mass	0.1	0.4	1.0	1.0	0.2	-0.3	-0.0	-0.9
Standing height	0.1	0.9	3.7	-0.1	0.2	0.6	-1.9	-0.5
Length of working week for main job	0.2	0.2	0.5	0.4	0.0	-0.7	0.4	-0.5
Exposure to tobacco smoke at home	0.5	0.6	1.8	-1.4	0.1	0.6	-0.7	0.6
Breastfed as a baby	0.1	0.1	0.5	-0.3	0.0	0.1	-0.7	0.3
Tense / ‘highly strung’	0.6	1.0	4.0	2.0	0.5	-0.5	0.8	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	1.3	0.9	-0.7	0.6	-1.2
Hair/balding pattern: Pattern 4	1.9	4.6	9.9	-1.0	-1.6	-3.1	2.9	1.2
Birth weight of first child	0.2	0.4	1.7	1.3	-0.4	-0.0	-0.5	0.2
Peak expiratory flow (PEF)	1.5	3.6	6.9	-1.8	-1.5	-2.2	-0.7	-2.6
Pulse wave reflection index	0.4	0.5	1.0	1.0	0.8	-0.4	-0.0	0.9
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.8	1.7	0.6	-0.3	-0.2	1.2
Loud music exposure frequency	1.5	1.6	4.8	-0.7	-1.4	-0.9	-2.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.5	-0.5	0.9	0.8	-1.6	-0.3
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	5.2	0.7	2.1	2.3	-0.2	1.5
Blood clot in the leg (DVT)	3.8	4.9	11.2	1.5	3.1	3.3	-0.5	1.0
Medication: Paracetamol	0.5	0.8	1.3	1.1	1.1	0.7	-0.8	0.5
Headache pain in last month	0.3	0.5	1.4	-0.6	-0.5	-0.7	-1.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	-0.9	-1.4	-0.6	-0.7	-1.6
Glaucoma (self-reported)	1.7	2.0	3.6	1.7	-1.1	-1.9	1.4	0.7
Gout (self-reported)	2.7	3.8	10.4	-1.2	-2.5	-3.2	-0.6	-0.4
Hypothyroidism/myxoedema (self-reported)	2.1	4.0	5.9	-1.8	-2.1	-2.4	-1.0	-2.4
Medication: Amlodipine	0.8	1.1	3.3	1.2	0.6	0.1	1.8	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	0.4	-0.2	-0.9	1.1	0.0
Birth weight	0.2	0.5	1.8	-0.6	-0.5	-0.4	-1.3	-0.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-0.2	-1.2	-1.0	0.7	0.2
High blood pressure (siblings)	3.8	5.4	10.4	-0.5	-3.0	-3.2	2.2	-1.7
Forced vital capacity (FVC), Best measure	0.7	2.7	5.1	-2.0	-0.4	-0.6	-1.9	-2.3
Body fat percentage	1.3	5.2	10.8	1.5	-1.0	-3.3	3.0	1.7
Leg fat percentage (right)	1.1	4.2	8.3	1.8	-0.6	-2.9	2.6	1.4
Arm fat-free mass (right)	0.1	0.6	1.0	0.9	-0.4	-1.0	0.6	-0.8
Exposure to tobacco smoke outside home	1.0	1.3	3.4	-0.9	1.2	1.8	0.5	-0.6
Comparative body size at age 10	0.3	0.9	2.7	1.0	-0.1	-1.6	-0.0	0.8
Number of full brothers	0.3	0.4	1.6	-1.2	0.1	0.1	-0.6	-0.1
Worry too long after embarrassment	0.2	0.3	0.9	1.0	0.2	-0.4	0.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	1.0	1.0	0.2	0.2	0.5	-0.5
Wheeze or whistling in the chest in last year	1.1	1.9	4.2	0.7	-2.0	-2.0	0.5	-0.8
Number of children fathered	1.6	1.8	4.0	1.0	2.0	0.8	1.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.6	6.9	-0.8	-1.9	-1.4	0.3	-2.6
Age at first live birth	1.1	1.9	3.3	1.6	0.8	1.8	-1.6	0.6
Pulse wave peak to peak time	1.4	1.7	5.7	-1.3	-0.6	0.6	0.5	-2.4
Health satisfaction	1.0	1.2	2.3	-0.6	-1.4	-1.5	0.2	-1.3
Shortness of breath walking on level ground	1.6	1.9	4.9	1.9	-0.2	-0.6	2.2	0.8
Qualifications: College or University degree	2.4	7.6	18.9	-1.0	2.4	4.3	-3.4	-0.4
Eye problems/disorders: None of the above	0.7	0.8	1.1	1.0	0.7	1.0	-0.9	0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.8	1.3	0.7	0.2	-1.0	0.3
Emphysema/chronic bronchitis	0.3	0.4	0.7	0.3	-0.6	-0.6	0.9	-0.5
Medication for pain relief, constipation, heartburn	0.5	0.9	2.1	-1.5	-1.0	-0.6	-0.0	-1.1
Neck or shoulder pain in last month	0.5	0.7	3.2	1.8	-0.2	-0.4	0.2	0.4
Medication: Blood pressure	0.3	0.6	1.2	0.6	-0.3	-1.1	0.9	0.5
Angina (self-reported)	1.7	2.2	5.4	1.5	-0.3	-0.3	1.8	2.3
Migraine (self-reported)	1.0	1.2	2.0	-0.9	-1.4	-1.1	-0.8	-1.1
Medication: Ibuprofen	0.7	0.8	1.6	1.2	-0.6	-0.6	-1.2	0.6
Medication: Allopurinol	2.6	3.4	10.8	-1.0	-2.1	-3.3	-0.8	0.4
Medication: Omeprazole	1.5	1.8	6.8	-0.0	-0.6	-0.9	2.6	-1.0
Medication: Seretide 50 evohaler	0.7	0.8	1.3	0.2	-1.0	-1.1	-1.1	-0.5
Mean time to correctly identify matches	2.0	3.8	11.4	1.4	1.0	0.8	2.0	3.4
Heart disease (mother)	0.5	0.6	1.3	-1.2	-1.0	-0.6	-0.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.5	-0.1	0.2	-0.1	-0.7
Whole body fat mass	1.1	4.5	8.6	1.8	-0.9	-2.9	2.8	1.3
Leg fat mass (right)	0.9	3.6	6.5	2.0	-0.6	-2.5	2.4	1.1
Arm predicted mass (right)	0.1	0.7	1.2	1.1	-0.2	-1.0	0.7	-0.8
Pulse rate, automated reading	0.4	1.2	4.3	-0.7	-0.3	-2.1	0.1	1.2
Alcohol intake frequency.	1.1	2.6	6.9	2.6	-0.7	-2.4	-0.4	0.3
Comparative height size at age 10	0.3	1.4	4.7	2.2	1.2	-0.1	-0.5	0.8
Number of full sisters	1.7	2.1	8.8	0.9	-0.6	-0.5	3.0	-0.7
Suffer from ‘nerves’	1.2	1.8	4.5	0.8	2.1	1.6	-0.0	1.2
Overall health rating	1.0	2.2	6.5	0.9	-1.2	-2.5	1.4	-0.0
Chest pain or discomfort	0.7	1.0	1.7	0.7	1.1	1.3	-1.2	-0.1
Had major operations	0.5	0.6	1.3	0.6	-0.2	-1.2	0.4	1.1
Age at last live birth	0.3	0.5	1.0	0.8	-1.0	0.2	-0.5	-0.7
Family relationship satisfaction	0.6	0.8	2.4	1.6	0.1	-0.7	1.0	-0.0
Leg pain on walking	0.4	0.5	1.4	0.1	-0.9	-0.0	-1.2	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	1.2	0.8	-0.2	0.5	0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.6	1.9	0.3	0.2	0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.4	-0.1	-0.7	-0.2	0.2	-0.4
Medication: Aspirin	0.6	0.8	2.3	0.4	0.4	0.3	1.2	1.5
Supplements: Vitamin C	0.5	0.5	1.0	-0.2	0.5	0.9	-0.8	-1.0
Knee pain experienced in last month	0.4	0.7	2.0	0.2	-0.8	-1.4	0.8	0.4
Hypertension (Self-reported)	0.9	2.4	5.5	-0.7	-1.3	-2.4	1.7	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	3.2	-0.8	-0.8	-0.3	0.4	-1.8
Illnesses of father: Heart disease	0.3	0.4	1.2	0.1	0.4	0.1	0.8	1.1
Illnesses of siblings: Diabetes	1.7	2.1	4.1	1.0	-0.8	-2.0	1.6	1.5
Smoking status: Previous	0.6	0.8	2.5	-0.5	0.0	1.0	-1.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.5	-0.3	0.6	1.2	-2.1	-0.7
Whole body fat-free mass	0.1	0.4	1.0	1.0	0.1	-0.5	0.2	-0.7
Leg fat-free mass (right)	0.0	0.2	0.5	0.7	-0.1	-0.5	0.3	-0.5
Arm fat percentage (left)	1.2	4.9	10.0	1.5	-0.9	-3.2	3.0	1.6
Average weekly red wine intake	0.6	0.9	1.9	-0.6	-0.0	0.9	-1.1	-1.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.7	0.2	1.3	1.2	0.6	-0.8
Mood swings	2.0	3.5	8.1	1.5	2.8	1.3	0.0	2.4
Loneliness, isolation	3.3	4.6	8.6	2.3	2.9	1.6	1.3	2.2
Long-standing illness, disability or infirmity	0.9	1.3	2.6	1.6	-1.3	-1.5	0.2	-0.3
Ever had bowel cancer screening	2.0	2.4	5.2	-0.2	-1.5	-1.8	2.3	1.1
Diabetes diagnosed by doctor	0.4	0.7	2.5	1.6	0.7	-0.1	-0.5	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	-0.2	-0.4	-0.1	-0.8	-0.4
Friendships satisfaction	2.2	2.7	4.2	1.6	1.7	1.6	1.1	2.0
Qualifications: nursing, teaching	4.0	6.3	9.6	2.5	3.0	3.1	-2.1	1.6
Commuting to job workplace: Walk	0.7	0.7	1.2	-0.7	-1.0	-0.1	-0.9	-1.1
Eye problems/disorders: Cataract	1.5	1.7	3.5	-1.9	-1.3	-1.2	-0.5	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	4.9	-0.6	-1.1	0.4	-1.6	-2.2
Medication for cholesterol	2.0	3.1	5.0	1.7	2.0	1.9	-0.2	2.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.4	0.1	0.5	0.7	0.3	-1.2
Back pain experienced in last month	0.5	0.8	2.0	1.4	0.5	-0.6	1.1	-0.5
Mineral and other dietary supplements	2.3	3.1	6.9	-0.1	2.2	1.8	-0.9	2.6
Breast cancer (self-reported)	0.6	0.7	1.3	-0.8	-0.8	-1.1	1.0	-0.3
Asthma (self-reported)	0.8	1.7	3.1	1.2	-1.1	-1.6	0.4	-1.8
Osteoporosis (self-reported)	0.4	0.5	1.5	-0.0	-0.6	-0.9	1.2	-0.0
Osteoarthritis (self-reported)	1.6	2.1	4.3	0.3	-2.1	-1.4	1.8	-1.0
Medication: Aspirin	0.4	0.5	1.2	0.6	-0.2	0.1	1.1	1.0
Medication: Gliclazide	3.9	4.5	9.3	1.8	2.6	3.0	-0.8	1.5
Illnesses of father: None of the above (group 1)	1.7	2.1	5.2	-1.2	-1.7	-2.3	-0.7	-0.7
Smoking status: Current	1.0	1.6	3.8	-0.2	-2.0	-1.6	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.3	-1.8	-0.2	-1.1	-0.7	-1.7
Whole body water mass	0.1	0.3	0.9	0.9	0.1	-0.6	0.3	-0.7
Leg predicted mass (right)	0.0	0.2	0.6	0.7	-0.0	-0.5	0.4	-0.4
Arm fat mass (left)	0.8	3.4	8.1	1.2	-0.9	-2.9	2.4	0.7
Number of self-reported non-cancer illnesses	1.1	1.8	2.2	1.5	-1.4	-1.4	1.3	-1.1
Average weekly champagne plus white wine intake	0.7	0.9	4.2	-0.3	0.3	2.0	0.3	0.4
Miserableness	0.2	0.3	0.8	0.6	0.9	0.5	-0.2	0.4
Guilty feelings	0.5	0.8	1.1	1.0	0.9	0.9	0.8	0.6
Wears glasses or contact lenses	1.2	1.4	2.7	1.5	0.4	-0.8	1.6	1.1
Ever taken oral contraceptive pill	1.8	2.0	4.2	0.3	1.7	2.1	-1.5	0.8
Hearing aid user	3.0	3.3	6.6	1.4	2.6	1.4	0.6	2.4
Mother’s age at death	0.2	0.3	0.6	0.4	-0.8	-0.1	0.7	0.4
Financial situation satisfaction	0.9	1.1	2.9	-0.7	0.0	0.2	-1.7	-1.5
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.7	1.3	0.5	0.2	1.1	0.5
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.6	-0.2	-0.6	-0.7	0.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.8	0.8	0.8	-0.4	1.4	0.8
Medication: Blood pressure	3.5	6.7	11.7	-2.3	-3.0	-3.4	1.3	-2.4
Pain type(s) experienced in last month: Hip pain	2.6	3.2	7.0	2.1	0.2	-1.5	2.6	1.6
Supplements: Fish oil (including cod liver oil)	5.6	7.3	13.8	-0.4	-3.7	-3.2	0.7	-3.4
High cholesterol (Self-reported)	0.4	0.7	1.7	-0.0	0.6	0.3	1.1	1.3
Medication: Bendroflumethiazide	4.6	7.1	10.8	-3.3	-2.9	-3.2	0.4	-2.4
Medication: Paracetamol	0.7	1.1	1.5	1.2	1.2	0.9	-0.9	1.0
Medication: Lisinopril	0.2	0.2	0.9	0.2	0.3	0.0	-0.1	0.9
Medication: Atorvastatin	0.2	0.2	0.4	-0.6	-0.1	-0.3	0.5	0.5
Illnesses of father: High blood pressure	1.3	1.6	3.2	-1.0	-0.3	1.4	-1.2	-1.8
Alcohol drinker status: Never	0.5	0.7	2.2	0.6	0.2	-0.7	-1.5	0.4
Ever smoked	1.1	2.0	4.2	0.2	-2.1	-0.6	-1.1	-2.0
Basal metabolic rate	0.1	0.6	1.2	1.1	-0.1	-1.0	0.7	-0.5
Leg fat percentage (left)	1.2	4.3	11.1	1.4	-1.0	-3.3	2.5	1.2
Arm fat-free mass (left)	0.1	0.6	1.3	0.5	-0.3	-1.1	0.7	-0.9
Number of operations (self-reported)	3.0	4.4	10.8	2.2	-0.7	-2.5	3.3	-0.1
Average weekly beer plus cider intake	0.1	0.2	0.3	-0.2	-0.5	-0.5	-0.4	0.3
Irritability	0.8	1.3	4.4	2.1	0.9	0.3	0.8	0.7
Risk taking	0.7	1.0	1.7	0.9	-0.2	1.3	-1.3	-0.8
Ever had prostate specific antigen (PSA) test	0.9	1.1	3.0	0.7	-1.1	-1.7	-0.5	-0.7
Fractured/broken bones in last 5 years	0.7	1.0	2.7	-0.2	-0.8	-1.1	1.6	-0.5
Age started oral contraceptive pill	0.7	0.9	2.9	-0.6	-0.4	0.2	1.7	1.1
Diastolic blood pressure, automated reading	2.2	6.9	18.7	-1.9	-3.0	-4.3	0.9	-1.7
Ever depressed for a whole week	0.3	0.4	0.8	0.9	0.4	-0.8	0.3	0.4
Unable to work because of sickness or disability	1.3	1.6	6.4	2.5	0.9	0.8	0.1	-0.5
Commuting to job workplace: Cycle	1.7	2.1	5.3	-2.3	-1.0	0.3	-0.8	-1.8
Myopia	0.6	0.9	2.3	-0.9	0.1	1.5	-1.1	-0.3
Vascular/heart problems diagnosed by doctor	0.8	2.1	5.3	-0.1	1.0	1.9	-2.3	0.9
Cholesterol lowering medication	1.1	1.6	4.4	-2.1	-1.3	-1.1	-0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	6.7	-0.3	-0.7	-1.3	2.6	-0.9
Pain experienced in last month	0.8	1.3	4.2	-2.0	-0.7	-0.4	-0.3	-1.4
Supplements: Calcium	0.1	0.1	0.1	0.2	0.3	0.3	-0.2	0.3
Basal cell carcinoma (self-reported)	1.1	1.3	3.7	0.0	-1.2	-1.0	-0.6	-1.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.6	-0.7	0.1	0.2	0.8	0.3
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	10.9	1.2	3.1	3.3	-0.6	0.9
Heart disease (siblings)	0.7	0.9	3.2	1.8	-1.1	0.2	0.2	0.4
Alcohol drinker status: Previous	0.5	0.6	1.1	1.0	0.8	0.0	-1.1	-0.1
Pack years of smoking	1.4	2.1	3.9	1.7	1.8	0.5	0.6	2.0
Impedance of whole body	0.2	1.1	2.1	-1.4	0.2	0.4	-1.4	1.2
Leg fat mass (left)	0.9	3.6	7.7	1.9	-0.8	-2.8	2.3	1.0
Arm predicted mass (left)	0.1	0.3	0.8	0.4	-0.2	-0.9	0.3	-0.8