Hub : Genes

NCALD

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0850 0.0290 7.1e-04 0.014 0.028 0.009 0.028 0.010 7.4e-03 2.0e-04 2.4e-02 2.0e-04 1.7e-02
2 GTEx Cells Transformed fibroblasts 0.1180 0.0410 2.7e-03 0.033 NA 0.031 NA 0.025 1.6e-03 NA 2.3e-03 NA 4.9e-03
3 GTEx Testis 0.2430 0.0650 4.8e-05 0.199 NA 0.172 NA 0.188 3.3e-09 NA 4.6e-08 NA 9.2e-09
4 NTR Blood 0.0221 0.0088 2.5e-03 0.000 0.009 -0.001 0.008 -0.001 3.1e-01 3.7e-04 7.1e-01 7.2e-04 6.4e-01
5 ROSMAP Brain Pre-frontal Cortex 0.0702 0.0213 2.4e-05 0.007 0.034 0.010 0.030 0.007 4.2e-02 2.6e-05 1.6e-02 7.8e-05 4.2e-02
6 YFS Blood 0.1223 0.0213 0.0e+00 0.083 0.079 0.086 0.091 0.090 8.2e-26 1.2e-24 8.9e-27 4.6e-28 5.7e-28

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.4 1.3 -0.2 0.7 1.1 0.4 -0.4 0.5
Bipolar Disorder or Schizophrenia 0.5 1.2 4.3 -0.4 1.0 2.1 -0.6 -1.0 -0.4
Depressed Affect (Nagel 2018) 0.4 0.9 3.0 1.7 0.2 1.2 -0.3 0.0 -0.9
Depression (Nagel 2018) 0.5 0.8 2.3 -0.2 -0.3 1.5 -0.8 -0.5 -1.2
Intelligence (Savage-Jansen 2018) 2.0 6.0 12.0 -3.5 0.7 3.4 -2.4 -2.5 -0.7
Neuroticism (Nagel 2018) 0.6 1.4 4.5 2.1 0.3 1.4 -1.1 0.8 -0.2
Schizophrenia (2018) 0.5 1.1 3.0 -0.4 0.7 1.7 -1.2 -1.0 -0.9
Schizophrenia vs Biploar Disorder 0.4 0.5 0.9 -0.4 -0.1 0.9 -0.8 -0.6 1.0
Worry (Nagel 2018) 1.2 2.6 10.2 1.1 0.8 1.9 -3.2 -0.0 -0.4
Alzheimer’s Disease (in mother) 4.1 4.8 11.9 3.5 -1.3 -2.6 1.9 2.2 0.3
Alzheimer’s Disease (in father) 0.2 0.2 0.7 0.5 0.1 -0.4 0.0 -0.5 -0.8
Alzheimer’s Disease (including proxy) 2.7 3.9 13.0 3.6 -0.6 -1.9 1.3 2.2 -0.2
Crohns Disease (2017) 0.4 0.8 4.1 0.1 -2.0 0.1 0.0 0.1 0.8
Irritable Bowel Disease (IBD) 0.4 0.9 2.0 1.4 -0.3 1.0 -0.4 1.2 1.0
Ulcerative Colitis (UC) 0.9 1.7 3.6 1.9 1.0 1.4 -0.9 1.6 0.4
Major Depression (MDD) 0.7 0.8 3.1 0.0 0.2 1.8 -0.7 -0.4 -1.1
Reaction Time 0.6 1.0 3.1 1.1 -0.9 -1.8 1.0 -0.2 -0.3
Verbal and Numeric Reasoning (VNR) 1.8 4.3 9.6 -3.1 -0.2 2.6 -1.5 -2.7 0.1
Breast Cancer 0.9 2.2 7.0 1.2 -2.6 -0.6 -0.6 1.5 1.3
Ovarian Cancer 1.2 1.6 5.2 -1.0 -1.5 -0.8 2.3 -0.7 -0.3
Prostate Cancer 0.2 0.3 1.8 0.4 0.1 -0.1 0.2 -0.2 -1.4
Age at First Birth 1.8 2.7 4.8 -1.6 1.3 1.4 -2.2 -1.5 -1.7
Bipolar Disorder (2011) 0.4 0.4 1.3 -0.3 -0.0 -0.4 1.1 -0.5 -0.7
Body Mass Index (BMI) (2010) 1.1 1.4 5.7 2.4 0.2 -0.7 0.8 1.3 0.1
Coronary Artery Disease (CAD) 0.7 0.8 2.2 0.5 -1.5 1.3 0.2 -0.6 -0.7
Crohns Disease (2012) 0.9 1.5 3.2 -0.4 -1.7 0.9 -1.3 -1.8 -0.5
Mean Putamen Volume 0.2 0.2 0.3 0.5 0.5 0.6 -0.2 0.5 -0.4
Fasting Glucose 1.1 1.3 2.8 0.4 -1.6 -1.4 1.7 0.4 0.1
HbA1C 0.6 0.6 2.9 -0.1 -0.4 0.6 0.4 -1.7 -0.4
HDL Cholesterol 0.4 0.6 1.9 -1.0 -0.1 -0.8 -0.2 -0.5 1.4
LDL Cholesterol 1.0 1.6 4.5 -1.0 -2.1 0.9 -0.9 -0.8 -1.4
Lupus 0.6 0.9 2.0 -1.4 -1.0 1.4 -0.6 -0.7 -0.3
Neuroticism (2016) 0.2 0.3 1.3 0.3 -0.3 1.1 -0.4 -0.3 -0.3
Primary Biliary Cirrhosis 0.9 1.3 5.2 0.6 0.4 -1.3 0.3 -0.2 -2.3
Rheumatoid Arthritis 0.1 0.1 0.4 0.1 0.4 -0.1 0.6 0.0 0.5
Schizophrenia (2014) 0.8 1.8 4.4 -1.3 0.9 2.1 -0.9 -1.5 -0.8
Triglycerides 0.5 0.8 2.7 -0.1 -1.6 0.5 -0.2 -0.6 -1.3
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.6 0.2 -1.3 -0.6 -0.1 -0.7 -1.2
Ulcerative Colitis 1.4 2.1 3.9 2.0 1.1 1.4 -1.5 1.5 1.0
Blood Eosinophil Count 0.2 1.5 3.9 -0.1 -1.7 2.0 -0.8 -0.1 -1.1
Blood Platelet Count 0.1 1.3 3.6 -1.9 -0.4 0.4 -0.4 -1.3 1.4
Blood Red Count 0.5 5.0 18.4 4.3 -0.1 2.3 -1.1 1.8 -1.3
Blood White Count 0.7 5.3 12.7 -1.4 -3.6 2.9 -0.1 -2.7 -1.1
Heel T-Score 0.1 0.6 1.6 1.0 1.3 -0.6 -0.8 0.1 -0.0
BMI 1.2 6.8 21.0 -2.5 -1.4 4.6 -0.8 -3.2 1.0
Height 0.3 5.1 10.0 -2.6 1.1 3.2 -1.9 -2.8 1.0
Waist Hip Ratio (WHR) 0.6 2.9 9.4 0.4 -2.2 1.4 -0.5 -0.8 -3.1
Systolic Blood Pressure 1.0 5.0 11.1 -2.2 -0.7 3.3 -2.8 -2.3 0.6
Smoking Status 0.3 0.8 2.2 1.5 0.2 -0.1 0.9 1.2 0.6
Allergy or Eczema 0.2 0.5 1.6 1.3 -0.4 -0.7 -0.5 0.6 0.0
Cardiovascular Disease 3.5 11.6 33.4 -3.7 -1.0 5.8 -1.7 -4.1 -1.3
Hypothyroidism (self reported) 0.7 1.5 3.6 -0.8 -1.4 1.9 -0.8 -1.2 0.8
Respiratory disease 0.3 0.7 1.7 1.3 0.3 -0.3 0.0 0.8 -1.2
Type 2 Diabetes (T2D) (2018) 1.3 2.4 6.5 -1.0 0.7 2.1 -0.9 -1.2 -2.5
Lung FEV1/FVC ratio 2.1 10.6 38.0 -2.0 -4.2 6.2 0.1 -1.5 1.1
Lung FVC 0.6 2.9 8.0 0.7 -1.4 -2.8 2.0 1.4 0.9
Neuroticism 0.7 1.8 3.3 1.8 1.3 1.2 -1.8 0.3 -0.9
Chronotype (morning person) 0.3 0.6 1.6 0.5 -0.1 0.7 -0.5 -1.2 -1.1
Hair Pigment 0.0 0.5 1.3 -1.1 -0.8 -0.5 0.1 -0.3 -0.7
Tanning 0.2 1.9 6.0 2.5 -1.0 -1.0 0.7 1.5 0.8
Hand grip strength (left) 0.4 1.1 3.3 -1.8 1.0 -0.5 0.2 -1.4 -0.2
Number of treatments/medications taken 1.1 2.0 4.0 -1.6 -0.8 1.6 -0.5 -2.0 -1.3
Average weekly spirits intake 0.9 1.1 3.1 -0.0 0.0 0.0 -1.7 -1.7 -1.0
Sensitivity / hurt feelings 1.7 3.0 7.6 2.2 0.4 -0.9 1.5 2.8 1.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.6 -0.2 -1.2 1.6 0.4 0.0 0.0
Hearing difficulty/problems: Yes 1.1 1.7 4.3 2.0 0.2 0.2 0.9 2.1 1.1
Relative age of first facial hair 1.6 3.3 8.6 -2.9 -0.6 1.2 -1.1 -2.5 -1.4
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 5.0 1.2 -2.2 0.2 -0.1 1.5 0.2
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.1 -0.8 -0.3 1.0 -1.5 -0.9 -1.4
Ever had hysterectomy (womb removed) 0.9 1.0 1.9 -1.2 1.0 1.4 0.2 -1.1 0.6
Systolic blood pressure, automated reading 1.3 3.8 7.4 -1.9 -1.6 2.7 -2.2 -2.0 0.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 1.7 1.3 -0.4 -0.7 0.1 1.3 0.5
Angina 1.8 2.4 9.2 -1.8 -1.2 3.0 0.1 -0.6 -0.4
Medication for hormone replacement therapy 0.7 0.7 2.5 -0.5 -0.1 1.0 -1.6 -0.7 -0.4
Vitamin and mineral supplements 0.4 0.6 1.0 0.9 0.9 0.4 0.3 1.0 0.6
Supplements: Zinc 0.5 0.6 1.4 -1.2 0.6 1.0 -0.3 -0.6 0.5
Medication: Co-codamol 3.0 3.4 8.6 1.4 -0.7 -2.9 2.3 2.0 0.3
Medication: Metformin 0.8 1.1 4.7 0.6 0.2 0.1 1.1 0.5 -2.2
Diabetes (father) 0.2 0.2 0.7 -0.3 -0.9 0.5 -0.1 -0.4 0.2
Diabetes (mother) 0.5 0.6 1.8 -1.3 -0.7 -0.3 -0.0 -0.5 -1.0
Severe depression (siblings) 0.3 0.4 1.1 0.5 -0.0 1.0 -0.1 -0.8 -0.5
Pack years adult smoking proportion 2.0 3.1 6.1 -1.3 -0.5 2.5 -2.1 -1.5 -2.0
Impedance of leg (right) 0.2 0.8 1.4 0.2 -1.1 -1.2 0.8 -0.2 -1.2
Leg fat-free mass (left) 0.9 4.9 10.7 -2.7 0.7 3.3 -1.1 -2.7 1.4
Trunk fat percentage 1.8 7.1 15.4 -3.4 -1.1 3.6 -1.3 -3.9 0.3
Hand grip strength (right) 0.5 1.4 4.1 -2.0 1.4 0.3 0.0 -1.5 -0.3
Townsend deprivation index at recruitment 0.9 1.3 3.8 0.1 -0.9 1.9 -0.7 -0.1 -1.7
Current tobacco smoking 0.8 1.3 2.9 1.3 -0.8 1.6 -0.1 0.1 -1.7
Average weekly fortified wine intake 0.5 0.6 1.0 0.8 0.7 -0.5 -0.7 1.0 -0.8
Maternal smoking around birth 0.3 0.4 1.7 -0.3 -0.2 0.5 0.7 -0.0 -1.3
Fed-up feelings 0.2 0.4 0.7 0.4 -0.8 0.8 -0.1 -0.5 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.1 -1.0 -0.1 1.0 -0.3 -0.1 0.5
Relative age voice broke 0.8 1.2 2.4 -1.1 -1.6 -0.8 0.8 -1.2 -0.8
Taking other prescription medications 0.2 0.4 0.8 0.5 -0.9 0.5 -0.7 0.0 -0.7
Age when periods started (menarche) 0.5 1.2 3.7 0.4 -1.6 -0.5 1.9 -0.2 0.7
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.7 -1.0 -0.4 -0.0 0.7 -1.3 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.6 6.2 -1.7 1.8 1.5 -0.9 -2.5 0.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.9 0.6 0.6 -0.9 1.4 0.9 0.4
Qualifications: CSEs or equivalent 3.2 4.3 8.7 1.3 1.3 -2.1 3.0 1.7 2.5
Serious illness, injury or assault to yourself 1.4 1.7 3.3 -1.7 -1.7 1.8 -1.0 -0.3 -0.4
High blood pressure 4.1 11.4 28.6 -3.8 -0.6 5.3 -2.8 -4.1 -0.8
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.1 1.0 0.3 -0.4 -1.1 0.4 -0.1
Multivitamins +/- minerals 1.0 1.3 3.6 -1.4 -0.3 -0.8 0.3 -1.9 -1.1
Stomach or abdominal pain in last month 1.2 1.5 2.1 -1.0 0.6 1.3 -1.4 -1.4 -1.3
Supplements: Glucosamine 1.4 1.9 5.2 0.3 -2.3 -1.4 1.8 -0.4 0.8
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 2.9 -0.2 -0.3 -1.1 0.8 -0.6 -1.7
Medication: Atenolol 2.1 2.6 4.5 -1.8 0.9 2.1 -1.5 -1.4 -1.8
Medication: Levothyroxine sodium 0.5 0.9 1.8 -0.8 -0.8 1.4 -0.4 -1.2 0.6
Sitting height 0.1 0.8 1.8 -0.5 1.0 1.2 0.1 -1.4 0.7
Chronic bronchitis/emphysema (father) 0.5 0.6 1.6 1.3 1.1 0.4 0.0 -0.1 -0.8
High blood pressure (mother) 1.6 2.3 5.3 -1.0 0.6 2.2 -2.3 -1.4 -0.6
Body mass index (BMI) 1.4 6.0 12.9 -3.2 -0.6 3.6 -1.1 -3.2 1.0
Impedance of leg (left) 0.1 0.7 2.6 0.3 -0.4 -1.1 0.3 -0.2 -1.6
Leg predicted mass (left) 0.9 4.6 10.3 -2.6 0.7 3.2 -1.1 -2.6 1.5
Trunk fat mass 1.9 8.1 16.5 -3.6 -0.7 4.1 -1.5 -4.0 0.7
Waist circumference 1.9 6.8 16.2 -2.8 -1.4 4.0 -1.1 -3.7 -0.3
Number of incorrect matches in round 0.3 0.5 1.3 0.8 -0.6 -1.1 0.7 0.6 -0.0
Past tobacco smoking 1.2 2.2 5.4 -0.8 0.8 1.4 -1.7 -1.2 -2.3
Alcohol usually taken with meals 1.2 1.9 2.7 1.0 -1.5 -1.5 1.0 1.5 1.6
Nervous feelings 2.0 3.7 9.4 3.1 1.4 -0.7 -1.1 2.8 1.0
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.9 -2.2 0.1 0.8 -0.3 -1.7 -0.0
Hearing difficulty/problems with background noise 0.8 1.3 2.7 1.6 -0.6 -1.1 1.0 1.3 0.9
Hair/balding pattern: Pattern 2 2.8 3.6 6.5 2.6 -0.1 -2.2 1.4 2.3 1.7
Had menopause 1.1 1.4 4.2 2.1 -0.8 -0.1 -0.2 1.3 -1.4
Had other major operations 1.5 1.8 4.2 -1.0 -2.0 1.5 0.4 -1.5 0.8
Forced vital capacity (FVC) 0.1 0.3 0.6 -0.5 0.5 0.1 0.6 -0.5 0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 8.0 -2.1 1.3 0.8 -0.2 -2.8 -0.3
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.4 -0.4 0.4 1.1 -1.2 -0.4 -0.4
Qualifications: None of the above 0.1 0.2 0.9 0.5 -1.0 0.3 0.4 0.3 0.1
Financial difficulties in last 2 years 0.6 0.9 3.8 -0.3 -0.6 1.9 0.4 -0.4 -0.8
Mouth/teeth dental problems 1.5 2.3 9.3 0.5 0.8 -3.0 1.5 0.4 1.1
Heart attack 2.8 3.6 7.1 -2.4 -0.1 2.7 -2.1 -1.8 -1.3
Allergy 0.1 0.3 1.3 -1.1 -0.3 0.3 0.4 -0.4 -0.1
Pain all over the body in last month 1.3 1.4 3.6 -1.7 -0.8 1.9 -0.3 -0.2 1.1
Diabetes (self-reported) 1.9 3.0 6.8 -1.3 -0.1 2.2 0.3 -2.1 -2.6
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.7 -0.1 -0.6 1.3 -0.3 -0.4 0.3
Medication: Ramipril 3.1 4.0 14.7 -0.9 0.8 3.8 -2.6 -0.9 -0.6
Medication: Simvastatin 0.2 0.3 0.9 -0.4 0.3 0.3 0.5 -0.5 -0.9
Fluid intelligence score 1.8 3.8 6.9 -2.6 -0.4 2.6 -1.8 -2.3 -0.8
Illnesses of siblings 0.9 1.3 2.5 0.6 -0.5 -1.6 1.4 0.3 1.5
Neuroticism score 0.5 1.0 3.7 1.9 0.7 0.4 -0.8 0.8 0.4
Weight 1.6 8.1 18.1 -3.5 0.0 4.3 -1.6 -3.7 1.3
Impedance of arm (right) 0.2 1.1 2.7 1.0 -0.4 -1.6 -0.1 1.1 -1.0
Arm fat percentage (right) 1.2 4.8 9.6 -3.0 -1.1 3.1 -1.0 -2.8 0.4
Trunk fat-free mass 0.4 2.5 6.9 -1.4 1.2 2.6 -1.1 -1.3 1.4
Hip circumference 1.6 6.8 13.5 -3.3 -0.2 3.7 -1.7 -3.4 1.3
Time employed in main current job 2.2 2.6 8.4 -1.3 -1.1 1.4 -0.5 -1.4 -2.9
Alcohol intake versus 10 years previously 0.4 0.6 1.5 0.8 1.2 -0.3 0.2 1.2 0.4
Father’s age at death 2.5 3.3 9.0 3.0 1.2 -1.3 -1.2 2.5 0.4
Worrier / anxious feelings 1.3 2.4 5.2 1.5 1.6 1.4 -2.3 1.2 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 4.4 -0.9 -1.5 2.1 0.1 -0.7 1.0
Falls in the last year 0.9 1.2 3.8 1.2 -1.1 0.6 0.0 1.9 -0.1
Hair/balding pattern: Pattern 3 2.8 4.2 6.9 -1.4 1.0 2.5 -2.6 -1.6 -2.6
Number of live births 0.9 1.3 3.3 1.0 1.1 -1.4 1.8 0.8 -0.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 2.9 -1.7 -0.4 1.5 0.4 -1.4 0.7
Pulse rate 0.6 1.0 2.5 1.6 -0.7 -0.9 1.2 0.7 0.5
Happiness 0.9 1.1 1.8 -1.3 -0.4 1.4 -1.1 -0.7 0.9
Noisy workplace 0.9 1.1 2.5 -0.0 0.3 -1.6 1.6 0.9 0.8
Qualifications: A levels/AS levels or equivalent 0.7 1.6 5.0 -0.5 2.2 0.5 -1.7 -0.0 -1.2
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 3.4 0.1 -1.8 0.3 -0.5 1.4 1.3
Mouth/teeth dental problems: Dentures 0.6 1.0 3.0 -0.8 0.4 1.7 -0.6 -0.7 -1.2
Asthma 1.8 3.6 6.9 2.6 0.8 -2.4 1.5 2.4 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.8 0.1 0.9 -0.5 0.0 0.4 0.7
Medication: Cholesterol lowering 0.6 0.9 1.6 -0.8 1.1 0.7 -1.0 -0.8 -1.3
Depression (self-reported) 0.4 0.5 1.4 -0.1 0.1 -0.4 0.7 0.8 1.2
Medication: Lansoprazole 0.5 0.5 1.1 -0.7 -1.0 0.5 0.2 -0.9 -0.8
Prospective memory result 1.5 1.9 5.3 1.1 -1.1 -0.6 1.7 0.6 -2.3
Lung cancer (father) 0.1 0.1 0.4 0.1 0.2 0.3 0.7 -0.4 0.4
Illnesses of mother 1.9 2.4 8.6 -0.3 0.2 -1.5 1.7 0.5 2.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 2.0 -1.4 -0.8 1.3 -0.1 -0.7 0.9
Pulse wave Arterial Stiffness index 0.6 0.7 1.6 1.1 1.3 0.2 -0.9 0.7 -0.4
Impedance of arm (left) 0.2 1.1 2.9 1.3 0.1 -1.7 0.1 0.9 -1.2
Arm fat mass (right) 1.8 7.4 14.3 -3.6 -0.6 3.8 -1.4 -3.8 0.5
Trunk predicted mass 0.4 2.5 6.9 -1.4 1.1 2.6 -1.0 -1.3 1.5
Standing height 0.2 1.7 3.0 -0.8 1.5 1.7 -1.3 -1.4 0.9
Length of working week for main job 0.5 0.6 1.0 -1.0 0.3 1.0 -0.7 -0.1 -0.8
Exposure to tobacco smoke at home 1.6 1.8 5.8 1.5 -0.4 -0.8 -1.1 0.8 -2.4
Breastfed as a baby 1.9 2.3 5.4 2.2 0.3 0.2 -2.3 1.7 -0.7
Tense / ‘highly strung’ 0.4 0.7 2.6 0.6 -0.6 0.8 -1.6 -0.0 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.6 3.5 -0.6 -0.3 1.9 -1.6 -0.6 1.6
Hair/balding pattern: Pattern 4 0.2 0.5 1.4 -0.1 -0.3 -0.4 1.1 -1.2 -0.5
Birth weight of first child 0.3 0.5 1.4 1.2 0.8 -0.7 -0.6 -0.1 0.6
Peak expiratory flow (PEF) 0.6 1.4 5.9 -1.3 0.5 2.4 -0.6 -0.2 0.6
Pulse wave reflection index 2.5 3.1 7.3 -0.8 1.3 1.9 -2.7 -1.5 -1.7
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.2 -0.1 -0.9 0.3 -0.0 -1.1 -0.4
Loud music exposure frequency 1.1 1.2 4.4 -0.9 -0.8 -0.1 1.1 0.1 2.1
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 3.9 -1.7 1.6 0.7 -1.2 -2.0 -0.3
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 4.8 -1.0 -0.5 2.2 -0.6 -1.4 -0.3
Blood clot in the leg (DVT) 0.3 0.4 1.1 -0.6 -0.3 0.9 -0.5 -1.0 -0.1
Medication: Paracetamol 0.5 0.9 3.0 -1.3 -0.0 -0.4 1.7 -0.6 0.5
Headache pain in last month 0.3 0.5 1.3 -1.0 0.5 0.5 0.3 -1.1 0.3
Medication for cholesterol, blood pressure or diabetes 1.6 2.7 4.1 2.0 -0.7 -1.6 1.6 1.6 2.0
Glaucoma (self-reported) 1.7 2.0 7.0 2.6 0.1 -0.8 -1.3 0.9 -1.5
Gout (self-reported) 0.2 0.3 0.5 0.3 -0.7 0.6 0.7 0.2 0.3
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 1.5 0.3 -1.2 1.1 -0.8 -0.7 0.3
Medication: Amlodipine 0.4 0.5 1.1 -1.0 1.0 1.1 -0.3 0.1 0.1
Medication: Ventolin 100micrograms inhaler 3.7 4.8 11.2 2.8 1.6 -2.5 0.9 3.3 -0.7
Birth weight 0.3 0.6 2.7 0.3 1.7 0.3 -0.7 -0.1 -0.1
Chronic bronchitis/emphysema (mother) 2.1 2.4 5.3 0.8 1.4 1.0 -2.2 -1.0 -2.3
High blood pressure (siblings) 1.1 1.5 3.5 -0.5 1.1 1.7 -0.9 0.7 -1.9
Forced vital capacity (FVC), Best measure 0.0 0.1 0.6 -0.4 -0.0 -0.0 0.1 0.1 0.8
Body fat percentage 1.8 6.9 13.9 -3.5 -1.2 3.5 -1.1 -3.7 0.5
Leg fat percentage (right) 1.5 5.3 10.4 -3.0 -1.5 3.1 -0.3 -3.2 1.0
Arm fat-free mass (right) 1.0 5.0 11.7 -2.5 1.0 3.4 -1.2 -2.8 1.2
Exposure to tobacco smoke outside home 0.3 0.5 1.9 -1.4 -0.2 -0.3 0.2 -0.4 0.6
Comparative body size at age 10 0.5 1.4 3.7 -0.2 0.8 1.2 -1.4 -0.6 1.9
Number of full brothers 1.5 1.9 3.7 0.9 0.3 -1.7 1.9 1.0 1.6
Worry too long after embarrassment 2.2 3.8 7.7 2.2 -0.9 -2.0 1.6 2.8 1.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 7.1 -0.1 -0.8 2.7 -2.3 -0.2 0.2
Wheeze or whistling in the chest in last year 1.0 1.9 4.2 -1.0 1.1 2.0 -0.8 -2.0 -0.1
Number of children fathered 0.5 0.6 1.9 -0.5 1.4 0.1 0.3 -0.6 1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 0.9 -0.3 1.0 -0.2 -0.5 0.8 0.8
Age at first live birth 0.9 1.6 5.9 -1.0 -0.3 -0.3 -1.1 -2.4 -1.2
Pulse wave peak to peak time 0.7 0.8 1.7 -1.1 -1.3 -0.3 0.9 -0.8 0.6
Health satisfaction 1.4 1.8 5.0 1.6 -1.4 -0.2 2.2 1.2 -0.2
Shortness of breath walking on level ground 0.4 0.4 1.2 -1.1 0.2 0.9 -0.7 0.1 -0.1
Qualifications: College or University degree 0.1 0.5 1.0 -0.5 0.6 0.0 -1.0 -0.3 1.0
Eye problems/disorders: None of the above 0.4 0.4 1.0 -0.6 0.8 -0.4 -1.0 -0.3 -0.5
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.6 1.3 -0.2 0.2 0.9 0.9 -0.8
Emphysema/chronic bronchitis 0.3 0.4 1.5 -0.0 0.5 1.2 -0.6 -0.2 -0.0
Medication for pain relief, constipation, heartburn 1.3 2.3 7.9 2.8 -0.7 -0.8 -0.8 1.9 0.5
Neck or shoulder pain in last month 0.4 0.6 1.4 0.7 0.4 -0.6 1.2 0.6 1.0
Medication: Blood pressure 1.8 3.2 4.9 -2.2 0.3 1.9 -1.6 -1.9 -2.1
Angina (self-reported) 1.5 2.0 7.4 -1.5 -1.2 2.7 0.1 -0.5 -0.6
Migraine (self-reported) 2.2 2.7 7.4 -0.7 2.0 0.9 0.2 -1.9 -2.7
Medication: Ibuprofen 0.3 0.3 1.6 0.3 1.2 -0.3 -0.5 0.1 -0.0
Medication: Allopurinol 0.2 0.3 0.9 0.1 0.2 -0.9 0.6 0.7 0.4
Medication: Omeprazole 0.7 0.8 1.2 -1.1 -0.7 1.1 -0.9 0.6 1.1
Medication: Seretide 50 evohaler 1.8 2.0 8.7 1.2 2.9 -0.4 -0.9 0.7 0.9
Mean time to correctly identify matches 0.6 1.2 2.1 1.4 -1.1 -1.4 -0.2 0.3 -1.4
Heart disease (mother) 0.3 0.3 1.0 -0.0 -0.4 1.0 -0.3 0.6 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.3 0.4 -0.5 -0.1 0.2 -0.3 0.4
Whole body fat mass 2.0 8.3 16.6 -3.9 -0.8 4.1 -1.2 -3.9 0.8
Leg fat mass (right) 2.0 7.9 15.9 -3.8 -0.8 3.8 -1.0 -4.0 1.0
Arm predicted mass (right) 1.0 5.2 12.5 -2.6 0.8 3.5 -1.0 -2.9 1.4
Pulse rate, automated reading 0.2 0.6 1.0 0.3 -0.2 0.9 -0.9 -1.0 -0.9
Alcohol intake frequency. 0.5 1.2 4.6 -0.7 -0.5 2.1 0.8 -0.8 -1.0
Comparative height size at age 10 0.1 0.5 1.7 0.3 -0.5 1.3 0.0 0.3 1.0
Number of full sisters 0.5 0.6 1.5 -0.0 1.0 1.2 -0.5 -0.7 0.4
Suffer from ‘nerves’ 0.3 0.5 1.2 0.3 0.3 1.1 -1.0 -0.9 -0.2
Overall health rating 1.6 3.5 6.4 -0.3 -2.5 2.1 2.2 -1.8 -1.5
Chest pain or discomfort 4.4 6.3 17.8 -2.3 0.3 4.2 -1.2 -3.5 -1.2
Had major operations 0.3 0.3 0.9 -0.5 0.3 -0.7 0.5 0.0 1.0
Age at last live birth 0.4 0.6 1.7 0.3 1.3 -1.0 -0.6 -0.5 -0.3
Family relationship satisfaction 0.6 0.7 2.0 0.4 -0.7 1.2 -1.4 -0.5 -0.1
Leg pain on walking 0.7 0.9 3.2 -0.0 -1.1 -0.5 1.8 0.5 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.9 1.1 4.5 0.1 0.1 -1.4 2.1 -0.2 -0.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.1 -0.8 -1.0 -0.1 1.4 -0.0 0.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.2 0.5 1.4 -1.8 1.1 -0.2 0.0
Medication: Aspirin 2.9 3.8 12.1 -3.5 -0.9 1.2 1.6 -2.4 -0.4
Supplements: Vitamin C 1.1 1.3 3.9 2.0 0.8 -0.2 -1.0 1.5 -0.4
Knee pain experienced in last month 1.0 1.5 4.0 1.0 -1.0 0.5 1.6 0.7 2.0
Hypertension (Self-reported) 3.8 10.5 27.9 -3.3 -1.1 5.3 -2.6 -3.9 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 5.2 -2.3 -0.2 0.1 1.4 -0.3 0.8
Illnesses of father: Heart disease 0.5 0.6 1.4 -1.2 -0.2 0.3 0.1 -1.2 1.0
Illnesses of siblings: Diabetes 0.4 0.5 1.6 1.3 0.5 0.9 -0.3 0.4 0.5
Smoking status: Previous 1.5 2.3 6.6 -0.3 -0.9 -1.3 2.1 0.2 2.6
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 5.2 -1.8 2.3 1.2 -1.1 -1.4 0.1
Whole body fat-free mass 0.6 3.7 9.5 -2.0 1.0 3.1 -1.2 -2.0 1.4
Leg fat-free mass (right) 0.8 4.4 9.8 -2.3 1.4 3.1 -1.5 -2.3 1.2
Arm fat percentage (left) 1.4 5.6 11.6 -3.1 -0.7 3.4 -1.1 -3.2 0.4
Average weekly red wine intake 1.4 2.1 4.7 1.2 -0.6 -2.2 1.2 1.4 1.6
Handedness (chirality/laterality): Left-handed 1.0 1.2 5.3 0.3 0.2 0.2 1.3 -0.4 -2.3
Mood swings 0.4 0.8 1.9 1.4 0.4 1.4 -0.8 0.3 -0.4
Loneliness, isolation 0.4 0.6 2.4 0.1 -0.5 1.5 0.6 -0.4 0.4
Long-standing illness, disability or infirmity 0.7 1.1 4.9 0.6 -2.2 0.9 0.4 -0.1 0.2
Ever had bowel cancer screening 3.9 4.6 11.6 1.0 -2.4 -0.6 2.2 1.9 3.4
Diabetes diagnosed by doctor 1.6 2.6 9.4 -0.5 0.1 2.1 -0.2 -1.2 -3.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.1 -0.9 -0.1 1.0 -0.1 -0.5 0.4
Friendships satisfaction 1.0 1.3 2.9 -0.2 -0.6 1.4 -1.7 -0.6 -1.3
Qualifications: nursing, teaching 0.3 0.4 1.2 1.1 0.4 -0.1 -0.8 0.6 -0.2
Commuting to job workplace: Walk 0.7 0.8 2.5 -0.6 1.6 -0.7 -0.3 -0.1 1.1
Eye problems/disorders: Cataract 0.7 0.9 1.8 1.2 0.0 -0.2 0.4 1.3 1.3
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.9 -0.5 -1.4 0.3 0.9 -0.1 1.7
Medication for cholesterol 3.3 5.0 13.2 2.1 1.2 -3.6 0.5 3.2 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 2.8 0.4 -1.7 -0.4 1.2 -0.1 -0.9
Back pain experienced in last month 1.3 2.0 6.1 2.5 -1.1 -1.0 0.9 1.5 -0.3
Mineral and other dietary supplements 1.1 1.5 4.0 -1.3 0.5 2.0 -1.4 -0.7 -0.7
Breast cancer (self-reported) 1.0 1.2 3.4 -0.5 0.7 -1.1 1.1 0.9 1.8
Asthma (self-reported) 1.2 2.3 4.2 2.0 0.7 -2.0 1.4 1.8 -0.3
Osteoporosis (self-reported) 2.5 3.2 10.7 2.8 -0.2 -0.2 0.4 3.3 -0.1
Osteoarthritis (self-reported) 1.1 1.4 4.1 -0.2 -1.5 -1.4 2.0 -0.4 0.1
Medication: Aspirin 3.0 3.9 12.1 -3.5 -0.7 1.2 1.4 -2.8 -0.1
Medication: Gliclazide 1.1 1.3 4.6 1.1 -0.2 0.5 -0.8 1.0 -2.2
Illnesses of father: None of the above (group 1) 0.6 0.7 2.1 -0.8 -0.1 -1.4 1.2 -0.0 0.1
Smoking status: Current 0.9 1.4 3.3 1.7 -0.8 1.1 -0.3 0.7 -1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 4.3 -0.9 -1.3 2.1 -1.4 -1.0 -0.3
Whole body water mass 0.7 3.9 9.7 -2.1 1.0 3.1 -1.3 -2.2 1.3
Leg predicted mass (right) 0.8 4.3 9.6 -2.3 1.3 3.1 -1.5 -2.4 1.2
Arm fat mass (left) 1.8 7.2 14.7 -3.4 -0.4 3.8 -1.5 -3.7 0.5
Number of self-reported non-cancer illnesses 0.9 1.5 4.0 -0.8 -1.5 2.0 0.6 -1.2 0.0
Average weekly champagne plus white wine intake 0.0 0.0 0.1 0.0 -0.0 0.0 0.3 0.3 -0.2
Miserableness 0.4 0.6 2.1 1.4 0.2 0.3 1.1 0.3 0.4
Guilty feelings 0.4 0.6 1.3 0.7 0.4 1.2 -0.9 0.5 0.6
Wears glasses or contact lenses 0.3 0.4 1.4 0.3 -1.2 -0.3 0.4 0.5 0.3
Ever taken oral contraceptive pill 0.3 0.3 0.8 -0.6 -0.9 0.1 0.4 -0.7 0.1
Hearing aid user 0.8 0.9 2.1 -1.2 -0.5 0.2 1.4 -0.3 1.4
Mother’s age at death 0.5 0.7 2.5 -0.9 0.9 -1.6 -0.2 0.0 0.0
Financial situation satisfaction 0.9 1.1 3.8 -1.2 1.9 0.1 0.3 0.1 1.1
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.1 1.8 -0.7 -0.8 -0.4 1.6 0.6
Commuting to job workplace: Public transport 2.0 2.3 8.2 2.9 -1.9 -0.4 -0.1 1.2 -0.8
Eye problems/disorders: Glaucoma 0.9 1.0 3.2 0.2 -0.2 0.3 -1.8 -1.4 -1.0
Medication: Blood pressure 4.2 7.9 21.3 -3.2 -1.6 4.6 -0.6 -3.6 0.6
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.0 -0.1 -1.3 1.4 0.4 -0.5 -1.0
Supplements: Fish oil (including cod liver oil) 0.8 1.1 4.2 2.0 -0.8 -1.0 0.1 0.5 0.6
High cholesterol (Self-reported) 0.5 0.9 2.1 -1.4 -0.5 0.7 0.9 -0.8 -1.0
Medication: Bendroflumethiazide 1.4 2.2 5.7 -1.4 -0.5 2.4 -0.4 -2.2 -0.4
Medication: Paracetamol 0.7 1.1 3.0 -1.7 0.1 0.2 0.9 -1.7 -0.0
Medication: Lisinopril 1.1 1.4 2.5 -1.6 -0.9 1.6 -0.5 -1.5 -0.2
Medication: Atorvastatin 1.2 1.4 2.3 -1.5 -0.7 1.3 -0.0 -1.4 -1.5
Illnesses of father: High blood pressure 1.0 1.2 2.8 1.7 0.1 1.3 -1.2 1.1 0.5
Alcohol drinker status: Never 0.7 0.9 4.7 0.4 -0.1 0.5 0.2 -0.0 -2.2
Ever smoked 0.6 1.0 2.2 1.3 -0.7 -0.4 0.3 1.1 1.5
Basal metabolic rate 0.9 5.2 12.5 -2.6 0.9 3.5 -1.4 -2.6 1.4
Leg fat percentage (left) 1.4 5.1 10.4 -3.0 -1.1 3.0 -0.4 -3.2 1.0
Arm fat-free mass (left) 0.9 4.7 11.7 -2.4 0.2 3.4 -1.2 -2.7 1.3
Number of operations (self-reported) 0.3 0.5 1.2 -0.5 -1.1 0.8 -0.4 -0.8 -0.0
Average weekly beer plus cider intake 0.7 1.1 2.3 -1.4 0.4 1.5 -0.5 -1.2 -0.5
Irritability 0.4 0.8 3.1 0.1 -0.1 0.5 -1.8 -1.0 -0.3
Risk taking 2.1 3.0 10.3 -0.4 0.0 2.6 -3.2 -0.6 -0.7
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.6 0.3 1.1 -1.1 1.0 0.6 1.3
Fractured/broken bones in last 5 years 0.7 0.9 3.0 0.2 -1.7 0.9 -0.9 0.8 0.2
Age started oral contraceptive pill 1.1 1.4 4.4 -1.0 -2.1 0.1 -0.4 -1.6 -0.1
Diastolic blood pressure, automated reading 1.6 4.8 12.1 -2.3 -0.2 3.5 -2.3 -2.5 0.1
Ever depressed for a whole week 0.6 0.8 2.2 -0.4 -0.5 1.5 -0.8 -1.1 0.2
Unable to work because of sickness or disability 1.7 2.2 10.3 -1.1 -3.2 1.2 0.1 -0.6 0.5
Commuting to job workplace: Cycle 0.8 0.9 4.0 -0.8 2.0 -0.1 -0.5 -0.8 -0.1
Myopia 0.2 0.3 0.7 0.8 0.8 -0.4 -0.1 0.6 -0.4
Vascular/heart problems diagnosed by doctor 4.2 11.4 31.1 3.6 0.2 -5.6 2.7 4.0 1.0
Cholesterol lowering medication 1.8 2.7 4.4 -1.9 -1.2 1.3 2.1 -1.9 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.8 -0.7 -0.2 0.7 -0.5 0.9 0.3
Pain experienced in last month 0.7 1.1 3.3 -0.4 0.9 -0.2 -1.4 -0.6 -1.8
Supplements: Calcium 0.8 0.9 1.9 0.6 -1.4 -0.4 -1.3 -0.6 -1.0
Basal cell carcinoma (self-reported) 1.0 1.1 5.0 -1.0 -0.9 -0.2 -0.4 -2.2 -0.1
Heart attack/myocardial infarction (self-reported) 2.8 3.7 7.1 -2.4 -0.4 2.7 -1.9 -1.9 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 2.2 -0.9 -0.7 1.0 -0.4 -1.5 -0.2
Heart disease (siblings) 0.5 0.6 1.5 -0.9 -0.5 1.2 -0.5 -0.2 -0.9
Alcohol drinker status: Previous 0.6 0.7 2.4 -0.1 -0.3 1.6 0.8 -1.0 -0.5
Pack years of smoking 2.5 3.7 6.2 -1.4 -0.6 2.5 -2.4 -1.7 -2.2
Impedance of whole body 0.2 0.9 2.1 0.8 -0.8 -1.4 0.6 0.1 -1.3
Leg fat mass (left) 2.0 7.9 15.9 -3.8 -0.7 3.8 -1.1 -4.0 0.9
Arm predicted mass (left) 0.9 4.5 10.3 -2.6 0.0 3.2 -1.0 -2.7 1.3