Hub : Genes

NCALD

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0850	0.0290	7.1e-04	0.014	0.028	0.009	0.028	0.010	7.4e-03	2.0e-04	2.4e-02	2.0e-04	1.7e-02
2	GTEx	Cells Transformed fibroblasts	0.1180	0.0410	2.7e-03	0.033	NA	0.031	NA	0.025	1.6e-03	NA	2.3e-03	NA	4.9e-03
3	GTEx	Testis	0.2430	0.0650	4.8e-05	0.199	NA	0.172	NA	0.188	3.3e-09	NA	4.6e-08	NA	9.2e-09
4	NTR	Blood	0.0221	0.0088	2.5e-03	0.000	0.009	-0.001	0.008	-0.001	3.1e-01	3.7e-04	7.1e-01	7.2e-04	6.4e-01
5	ROSMAP	Brain Pre-frontal Cortex	0.0702	0.0213	2.4e-05	0.007	0.034	0.010	0.030	0.007	4.2e-02	2.6e-05	1.6e-02	7.8e-05	4.2e-02
6	YFS	Blood	0.1223	0.0213	0.0e+00	0.083	0.079	0.086	0.091	0.090	8.2e-26	1.2e-24	8.9e-27	4.6e-28	5.7e-28

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.2	0.4	1.3	-0.2	0.7	1.1	0.4	-0.4	0.5
Bipolar Disorder or Schizophrenia	0.5	1.2	4.3	-0.4	1.0	2.1	-0.6	-1.0	-0.4
Depressed Affect (Nagel 2018)	0.4	0.9	3.0	1.7	0.2	1.2	-0.3	0.0	-0.9
Depression (Nagel 2018)	0.5	0.8	2.3	-0.2	-0.3	1.5	-0.8	-0.5	-1.2
Intelligence (Savage-Jansen 2018)	2.0	6.0	12.0	-3.5	0.7	3.4	-2.4	-2.5	-0.7
Neuroticism (Nagel 2018)	0.6	1.4	4.5	2.1	0.3	1.4	-1.1	0.8	-0.2
Schizophrenia (2018)	0.5	1.1	3.0	-0.4	0.7	1.7	-1.2	-1.0	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	0.9	-0.4	-0.1	0.9	-0.8	-0.6	1.0
Worry (Nagel 2018)	1.2	2.6	10.2	1.1	0.8	1.9	-3.2	-0.0	-0.4
Alzheimer’s Disease (in mother)	4.1	4.8	11.9	3.5	-1.3	-2.6	1.9	2.2	0.3
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.5	0.1	-0.4	0.0	-0.5	-0.8
Alzheimer’s Disease (including proxy)	2.7	3.9	13.0	3.6	-0.6	-1.9	1.3	2.2	-0.2
Crohns Disease (2017)	0.4	0.8	4.1	0.1	-2.0	0.1	0.0	0.1	0.8
Irritable Bowel Disease (IBD)	0.4	0.9	2.0	1.4	-0.3	1.0	-0.4	1.2	1.0
Ulcerative Colitis (UC)	0.9	1.7	3.6	1.9	1.0	1.4	-0.9	1.6	0.4
Major Depression (MDD)	0.7	0.8	3.1	0.0	0.2	1.8	-0.7	-0.4	-1.1
Reaction Time	0.6	1.0	3.1	1.1	-0.9	-1.8	1.0	-0.2	-0.3
Verbal and Numeric Reasoning (VNR)	1.8	4.3	9.6	-3.1	-0.2	2.6	-1.5	-2.7	0.1
Breast Cancer	0.9	2.2	7.0	1.2	-2.6	-0.6	-0.6	1.5	1.3
Ovarian Cancer	1.2	1.6	5.2	-1.0	-1.5	-0.8	2.3	-0.7	-0.3
Prostate Cancer	0.2	0.3	1.8	0.4	0.1	-0.1	0.2	-0.2	-1.4
Age at First Birth	1.8	2.7	4.8	-1.6	1.3	1.4	-2.2	-1.5	-1.7
Bipolar Disorder (2011)	0.4	0.4	1.3	-0.3	-0.0	-0.4	1.1	-0.5	-0.7
Body Mass Index (BMI) (2010)	1.1	1.4	5.7	2.4	0.2	-0.7	0.8	1.3	0.1
Coronary Artery Disease (CAD)	0.7	0.8	2.2	0.5	-1.5	1.3	0.2	-0.6	-0.7
Crohns Disease (2012)	0.9	1.5	3.2	-0.4	-1.7	0.9	-1.3	-1.8	-0.5
Mean Putamen Volume	0.2	0.2	0.3	0.5	0.5	0.6	-0.2	0.5	-0.4
Fasting Glucose	1.1	1.3	2.8	0.4	-1.6	-1.4	1.7	0.4	0.1
HbA1C	0.6	0.6	2.9	-0.1	-0.4	0.6	0.4	-1.7	-0.4
HDL Cholesterol	0.4	0.6	1.9	-1.0	-0.1	-0.8	-0.2	-0.5	1.4
LDL Cholesterol	1.0	1.6	4.5	-1.0	-2.1	0.9	-0.9	-0.8	-1.4
Lupus	0.6	0.9	2.0	-1.4	-1.0	1.4	-0.6	-0.7	-0.3
Neuroticism (2016)	0.2	0.3	1.3	0.3	-0.3	1.1	-0.4	-0.3	-0.3
Primary Biliary Cirrhosis	0.9	1.3	5.2	0.6	0.4	-1.3	0.3	-0.2	-2.3
Rheumatoid Arthritis	0.1	0.1	0.4	0.1	0.4	-0.1	0.6	0.0	0.5
Schizophrenia (2014)	0.8	1.8	4.4	-1.3	0.9	2.1	-0.9	-1.5	-0.8
Triglycerides	0.5	0.8	2.7	-0.1	-1.6	0.5	-0.2	-0.6	-1.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.6	0.2	-1.3	-0.6	-0.1	-0.7	-1.2
Ulcerative Colitis	1.4	2.1	3.9	2.0	1.1	1.4	-1.5	1.5	1.0
Blood Eosinophil Count	0.2	1.5	3.9	-0.1	-1.7	2.0	-0.8	-0.1	-1.1
Blood Platelet Count	0.1	1.3	3.6	-1.9	-0.4	0.4	-0.4	-1.3	1.4
Blood Red Count	0.5	5.0	18.4	4.3	-0.1	2.3	-1.1	1.8	-1.3
Blood White Count	0.7	5.3	12.7	-1.4	-3.6	2.9	-0.1	-2.7	-1.1
Heel T-Score	0.1	0.6	1.6	1.0	1.3	-0.6	-0.8	0.1	-0.0
BMI	1.2	6.8	21.0	-2.5	-1.4	4.6	-0.8	-3.2	1.0
Height	0.3	5.1	10.0	-2.6	1.1	3.2	-1.9	-2.8	1.0
Waist Hip Ratio (WHR)	0.6	2.9	9.4	0.4	-2.2	1.4	-0.5	-0.8	-3.1
Systolic Blood Pressure	1.0	5.0	11.1	-2.2	-0.7	3.3	-2.8	-2.3	0.6
Smoking Status	0.3	0.8	2.2	1.5	0.2	-0.1	0.9	1.2	0.6
Allergy or Eczema	0.2	0.5	1.6	1.3	-0.4	-0.7	-0.5	0.6	0.0
Cardiovascular Disease	3.5	11.6	33.4	-3.7	-1.0	5.8	-1.7	-4.1	-1.3
Hypothyroidism (self reported)	0.7	1.5	3.6	-0.8	-1.4	1.9	-0.8	-1.2	0.8
Respiratory disease	0.3	0.7	1.7	1.3	0.3	-0.3	0.0	0.8	-1.2
Type 2 Diabetes (T2D) (2018)	1.3	2.4	6.5	-1.0	0.7	2.1	-0.9	-1.2	-2.5
Lung FEV1/FVC ratio	2.1	10.6	38.0	-2.0	-4.2	6.2	0.1	-1.5	1.1
Lung FVC	0.6	2.9	8.0	0.7	-1.4	-2.8	2.0	1.4	0.9
Neuroticism	0.7	1.8	3.3	1.8	1.3	1.2	-1.8	0.3	-0.9
Chronotype (morning person)	0.3	0.6	1.6	0.5	-0.1	0.7	-0.5	-1.2	-1.1
Hair Pigment	0.0	0.5	1.3	-1.1	-0.8	-0.5	0.1	-0.3	-0.7
Tanning	0.2	1.9	6.0	2.5	-1.0	-1.0	0.7	1.5	0.8
Hand grip strength (left)	0.4	1.1	3.3	-1.8	1.0	-0.5	0.2	-1.4	-0.2
Number of treatments/medications taken	1.1	2.0	4.0	-1.6	-0.8	1.6	-0.5	-2.0	-1.3
Average weekly spirits intake	0.9	1.1	3.1	-0.0	0.0	0.0	-1.7	-1.7	-1.0
Sensitivity / hurt feelings	1.7	3.0	7.6	2.2	0.4	-0.9	1.5	2.8	1.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.6	-0.2	-1.2	1.6	0.4	0.0	0.0
Hearing difficulty/problems: Yes	1.1	1.7	4.3	2.0	0.2	0.2	0.9	2.1	1.1
Relative age of first facial hair	1.6	3.3	8.6	-2.9	-0.6	1.2	-1.1	-2.5	-1.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	5.0	1.2	-2.2	0.2	-0.1	1.5	0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.1	-0.8	-0.3	1.0	-1.5	-0.9	-1.4
Ever had hysterectomy (womb removed)	0.9	1.0	1.9	-1.2	1.0	1.4	0.2	-1.1	0.6
Systolic blood pressure, automated reading	1.3	3.8	7.4	-1.9	-1.6	2.7	-2.2	-2.0	0.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.7	1.3	-0.4	-0.7	0.1	1.3	0.5
Angina	1.8	2.4	9.2	-1.8	-1.2	3.0	0.1	-0.6	-0.4
Medication for hormone replacement therapy	0.7	0.7	2.5	-0.5	-0.1	1.0	-1.6	-0.7	-0.4
Vitamin and mineral supplements	0.4	0.6	1.0	0.9	0.9	0.4	0.3	1.0	0.6
Supplements: Zinc	0.5	0.6	1.4	-1.2	0.6	1.0	-0.3	-0.6	0.5
Medication: Co-codamol	3.0	3.4	8.6	1.4	-0.7	-2.9	2.3	2.0	0.3
Medication: Metformin	0.8	1.1	4.7	0.6	0.2	0.1	1.1	0.5	-2.2
Diabetes (father)	0.2	0.2	0.7	-0.3	-0.9	0.5	-0.1	-0.4	0.2
Diabetes (mother)	0.5	0.6	1.8	-1.3	-0.7	-0.3	-0.0	-0.5	-1.0
Severe depression (siblings)	0.3	0.4	1.1	0.5	-0.0	1.0	-0.1	-0.8	-0.5
Pack years adult smoking proportion	2.0	3.1	6.1	-1.3	-0.5	2.5	-2.1	-1.5	-2.0
Impedance of leg (right)	0.2	0.8	1.4	0.2	-1.1	-1.2	0.8	-0.2	-1.2
Leg fat-free mass (left)	0.9	4.9	10.7	-2.7	0.7	3.3	-1.1	-2.7	1.4
Trunk fat percentage	1.8	7.1	15.4	-3.4	-1.1	3.6	-1.3	-3.9	0.3
Hand grip strength (right)	0.5	1.4	4.1	-2.0	1.4	0.3	0.0	-1.5	-0.3
Townsend deprivation index at recruitment	0.9	1.3	3.8	0.1	-0.9	1.9	-0.7	-0.1	-1.7
Current tobacco smoking	0.8	1.3	2.9	1.3	-0.8	1.6	-0.1	0.1	-1.7
Average weekly fortified wine intake	0.5	0.6	1.0	0.8	0.7	-0.5	-0.7	1.0	-0.8
Maternal smoking around birth	0.3	0.4	1.7	-0.3	-0.2	0.5	0.7	-0.0	-1.3
Fed-up feelings	0.2	0.4	0.7	0.4	-0.8	0.8	-0.1	-0.5	-0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-1.0	-0.1	1.0	-0.3	-0.1	0.5
Relative age voice broke	0.8	1.2	2.4	-1.1	-1.6	-0.8	0.8	-1.2	-0.8
Taking other prescription medications	0.2	0.4	0.8	0.5	-0.9	0.5	-0.7	0.0	-0.7
Age when periods started (menarche)	0.5	1.2	3.7	0.4	-1.6	-0.5	1.9	-0.2	0.7
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-1.0	-0.4	-0.0	0.7	-1.3	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.6	6.2	-1.7	1.8	1.5	-0.9	-2.5	0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.9	0.6	0.6	-0.9	1.4	0.9	0.4
Qualifications: CSEs or equivalent	3.2	4.3	8.7	1.3	1.3	-2.1	3.0	1.7	2.5
Serious illness, injury or assault to yourself	1.4	1.7	3.3	-1.7	-1.7	1.8	-1.0	-0.3	-0.4
High blood pressure	4.1	11.4	28.6	-3.8	-0.6	5.3	-2.8	-4.1	-0.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	1.0	0.3	-0.4	-1.1	0.4	-0.1
Multivitamins +/- minerals	1.0	1.3	3.6	-1.4	-0.3	-0.8	0.3	-1.9	-1.1
Stomach or abdominal pain in last month	1.2	1.5	2.1	-1.0	0.6	1.3	-1.4	-1.4	-1.3
Supplements: Glucosamine	1.4	1.9	5.2	0.3	-2.3	-1.4	1.8	-0.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.9	-0.2	-0.3	-1.1	0.8	-0.6	-1.7
Medication: Atenolol	2.1	2.6	4.5	-1.8	0.9	2.1	-1.5	-1.4	-1.8
Medication: Levothyroxine sodium	0.5	0.9	1.8	-0.8	-0.8	1.4	-0.4	-1.2	0.6
Sitting height	0.1	0.8	1.8	-0.5	1.0	1.2	0.1	-1.4	0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	1.3	1.1	0.4	0.0	-0.1	-0.8
High blood pressure (mother)	1.6	2.3	5.3	-1.0	0.6	2.2	-2.3	-1.4	-0.6
Body mass index (BMI)	1.4	6.0	12.9	-3.2	-0.6	3.6	-1.1	-3.2	1.0
Impedance of leg (left)	0.1	0.7	2.6	0.3	-0.4	-1.1	0.3	-0.2	-1.6
Leg predicted mass (left)	0.9	4.6	10.3	-2.6	0.7	3.2	-1.1	-2.6	1.5
Trunk fat mass	1.9	8.1	16.5	-3.6	-0.7	4.1	-1.5	-4.0	0.7
Waist circumference	1.9	6.8	16.2	-2.8	-1.4	4.0	-1.1	-3.7	-0.3
Number of incorrect matches in round	0.3	0.5	1.3	0.8	-0.6	-1.1	0.7	0.6	-0.0
Past tobacco smoking	1.2	2.2	5.4	-0.8	0.8	1.4	-1.7	-1.2	-2.3
Alcohol usually taken with meals	1.2	1.9	2.7	1.0	-1.5	-1.5	1.0	1.5	1.6
Nervous feelings	2.0	3.7	9.4	3.1	1.4	-0.7	-1.1	2.8	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.9	-2.2	0.1	0.8	-0.3	-1.7	-0.0
Hearing difficulty/problems with background noise	0.8	1.3	2.7	1.6	-0.6	-1.1	1.0	1.3	0.9
Hair/balding pattern: Pattern 2	2.8	3.6	6.5	2.6	-0.1	-2.2	1.4	2.3	1.7
Had menopause	1.1	1.4	4.2	2.1	-0.8	-0.1	-0.2	1.3	-1.4
Had other major operations	1.5	1.8	4.2	-1.0	-2.0	1.5	0.4	-1.5	0.8
Forced vital capacity (FVC)	0.1	0.3	0.6	-0.5	0.5	0.1	0.6	-0.5	0.8
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	8.0	-2.1	1.3	0.8	-0.2	-2.8	-0.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.4	-0.4	0.4	1.1	-1.2	-0.4	-0.4
Qualifications: None of the above	0.1	0.2	0.9	0.5	-1.0	0.3	0.4	0.3	0.1
Financial difficulties in last 2 years	0.6	0.9	3.8	-0.3	-0.6	1.9	0.4	-0.4	-0.8
Mouth/teeth dental problems	1.5	2.3	9.3	0.5	0.8	-3.0	1.5	0.4	1.1
Heart attack	2.8	3.6	7.1	-2.4	-0.1	2.7	-2.1	-1.8	-1.3
Allergy	0.1	0.3	1.3	-1.1	-0.3	0.3	0.4	-0.4	-0.1
Pain all over the body in last month	1.3	1.4	3.6	-1.7	-0.8	1.9	-0.3	-0.2	1.1
Diabetes (self-reported)	1.9	3.0	6.8	-1.3	-0.1	2.2	0.3	-2.1	-2.6
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.7	-0.1	-0.6	1.3	-0.3	-0.4	0.3
Medication: Ramipril	3.1	4.0	14.7	-0.9	0.8	3.8	-2.6	-0.9	-0.6
Medication: Simvastatin	0.2	0.3	0.9	-0.4	0.3	0.3	0.5	-0.5	-0.9
Fluid intelligence score	1.8	3.8	6.9	-2.6	-0.4	2.6	-1.8	-2.3	-0.8
Illnesses of siblings	0.9	1.3	2.5	0.6	-0.5	-1.6	1.4	0.3	1.5
Neuroticism score	0.5	1.0	3.7	1.9	0.7	0.4	-0.8	0.8	0.4
Weight	1.6	8.1	18.1	-3.5	0.0	4.3	-1.6	-3.7	1.3
Impedance of arm (right)	0.2	1.1	2.7	1.0	-0.4	-1.6	-0.1	1.1	-1.0
Arm fat percentage (right)	1.2	4.8	9.6	-3.0	-1.1	3.1	-1.0	-2.8	0.4
Trunk fat-free mass	0.4	2.5	6.9	-1.4	1.2	2.6	-1.1	-1.3	1.4
Hip circumference	1.6	6.8	13.5	-3.3	-0.2	3.7	-1.7	-3.4	1.3
Time employed in main current job	2.2	2.6	8.4	-1.3	-1.1	1.4	-0.5	-1.4	-2.9
Alcohol intake versus 10 years previously	0.4	0.6	1.5	0.8	1.2	-0.3	0.2	1.2	0.4
Father’s age at death	2.5	3.3	9.0	3.0	1.2	-1.3	-1.2	2.5	0.4
Worrier / anxious feelings	1.3	2.4	5.2	1.5	1.6	1.4	-2.3	1.2	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	4.4	-0.9	-1.5	2.1	0.1	-0.7	1.0
Falls in the last year	0.9	1.2	3.8	1.2	-1.1	0.6	0.0	1.9	-0.1
Hair/balding pattern: Pattern 3	2.8	4.2	6.9	-1.4	1.0	2.5	-2.6	-1.6	-2.6
Number of live births	0.9	1.3	3.3	1.0	1.1	-1.4	1.8	0.8	-0.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.9	-1.7	-0.4	1.5	0.4	-1.4	0.7
Pulse rate	0.6	1.0	2.5	1.6	-0.7	-0.9	1.2	0.7	0.5
Happiness	0.9	1.1	1.8	-1.3	-0.4	1.4	-1.1	-0.7	0.9
Noisy workplace	0.9	1.1	2.5	-0.0	0.3	-1.6	1.6	0.9	0.8
Qualifications: A levels/AS levels or equivalent	0.7	1.6	5.0	-0.5	2.2	0.5	-1.7	-0.0	-1.2
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.4	0.1	-1.8	0.3	-0.5	1.4	1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	3.0	-0.8	0.4	1.7	-0.6	-0.7	-1.2
Asthma	1.8	3.6	6.9	2.6	0.8	-2.4	1.5	2.4	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	0.1	0.9	-0.5	0.0	0.4	0.7
Medication: Cholesterol lowering	0.6	0.9	1.6	-0.8	1.1	0.7	-1.0	-0.8	-1.3
Depression (self-reported)	0.4	0.5	1.4	-0.1	0.1	-0.4	0.7	0.8	1.2
Medication: Lansoprazole	0.5	0.5	1.1	-0.7	-1.0	0.5	0.2	-0.9	-0.8
Prospective memory result	1.5	1.9	5.3	1.1	-1.1	-0.6	1.7	0.6	-2.3
Lung cancer (father)	0.1	0.1	0.4	0.1	0.2	0.3	0.7	-0.4	0.4
Illnesses of mother	1.9	2.4	8.6	-0.3	0.2	-1.5	1.7	0.5	2.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.0	-1.4	-0.8	1.3	-0.1	-0.7	0.9
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	1.1	1.3	0.2	-0.9	0.7	-0.4
Impedance of arm (left)	0.2	1.1	2.9	1.3	0.1	-1.7	0.1	0.9	-1.2
Arm fat mass (right)	1.8	7.4	14.3	-3.6	-0.6	3.8	-1.4	-3.8	0.5
Trunk predicted mass	0.4	2.5	6.9	-1.4	1.1	2.6	-1.0	-1.3	1.5
Standing height	0.2	1.7	3.0	-0.8	1.5	1.7	-1.3	-1.4	0.9
Length of working week for main job	0.5	0.6	1.0	-1.0	0.3	1.0	-0.7	-0.1	-0.8
Exposure to tobacco smoke at home	1.6	1.8	5.8	1.5	-0.4	-0.8	-1.1	0.8	-2.4
Breastfed as a baby	1.9	2.3	5.4	2.2	0.3	0.2	-2.3	1.7	-0.7
Tense / ‘highly strung’	0.4	0.7	2.6	0.6	-0.6	0.8	-1.6	-0.0	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.5	-0.6	-0.3	1.9	-1.6	-0.6	1.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.4	-0.1	-0.3	-0.4	1.1	-1.2	-0.5
Birth weight of first child	0.3	0.5	1.4	1.2	0.8	-0.7	-0.6	-0.1	0.6
Peak expiratory flow (PEF)	0.6	1.4	5.9	-1.3	0.5	2.4	-0.6	-0.2	0.6
Pulse wave reflection index	2.5	3.1	7.3	-0.8	1.3	1.9	-2.7	-1.5	-1.7
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.2	-0.1	-0.9	0.3	-0.0	-1.1	-0.4
Loud music exposure frequency	1.1	1.2	4.4	-0.9	-0.8	-0.1	1.1	0.1	2.1
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	3.9	-1.7	1.6	0.7	-1.2	-2.0	-0.3
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.8	-1.0	-0.5	2.2	-0.6	-1.4	-0.3
Blood clot in the leg (DVT)	0.3	0.4	1.1	-0.6	-0.3	0.9	-0.5	-1.0	-0.1
Medication: Paracetamol	0.5	0.9	3.0	-1.3	-0.0	-0.4	1.7	-0.6	0.5
Headache pain in last month	0.3	0.5	1.3	-1.0	0.5	0.5	0.3	-1.1	0.3
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	4.1	2.0	-0.7	-1.6	1.6	1.6	2.0
Glaucoma (self-reported)	1.7	2.0	7.0	2.6	0.1	-0.8	-1.3	0.9	-1.5
Gout (self-reported)	0.2	0.3	0.5	0.3	-0.7	0.6	0.7	0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.5	0.3	-1.2	1.1	-0.8	-0.7	0.3
Medication: Amlodipine	0.4	0.5	1.1	-1.0	1.0	1.1	-0.3	0.1	0.1
Medication: Ventolin 100micrograms inhaler	3.7	4.8	11.2	2.8	1.6	-2.5	0.9	3.3	-0.7
Birth weight	0.3	0.6	2.7	0.3	1.7	0.3	-0.7	-0.1	-0.1
Chronic bronchitis/emphysema (mother)	2.1	2.4	5.3	0.8	1.4	1.0	-2.2	-1.0	-2.3
High blood pressure (siblings)	1.1	1.5	3.5	-0.5	1.1	1.7	-0.9	0.7	-1.9
Forced vital capacity (FVC), Best measure	0.0	0.1	0.6	-0.4	-0.0	-0.0	0.1	0.1	0.8
Body fat percentage	1.8	6.9	13.9	-3.5	-1.2	3.5	-1.1	-3.7	0.5
Leg fat percentage (right)	1.5	5.3	10.4	-3.0	-1.5	3.1	-0.3	-3.2	1.0
Arm fat-free mass (right)	1.0	5.0	11.7	-2.5	1.0	3.4	-1.2	-2.8	1.2
Exposure to tobacco smoke outside home	0.3	0.5	1.9	-1.4	-0.2	-0.3	0.2	-0.4	0.6
Comparative body size at age 10	0.5	1.4	3.7	-0.2	0.8	1.2	-1.4	-0.6	1.9
Number of full brothers	1.5	1.9	3.7	0.9	0.3	-1.7	1.9	1.0	1.6
Worry too long after embarrassment	2.2	3.8	7.7	2.2	-0.9	-2.0	1.6	2.8	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	7.1	-0.1	-0.8	2.7	-2.3	-0.2	0.2
Wheeze or whistling in the chest in last year	1.0	1.9	4.2	-1.0	1.1	2.0	-0.8	-2.0	-0.1
Number of children fathered	0.5	0.6	1.9	-0.5	1.4	0.1	0.3	-0.6	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.9	-0.3	1.0	-0.2	-0.5	0.8	0.8
Age at first live birth	0.9	1.6	5.9	-1.0	-0.3	-0.3	-1.1	-2.4	-1.2
Pulse wave peak to peak time	0.7	0.8	1.7	-1.1	-1.3	-0.3	0.9	-0.8	0.6
Health satisfaction	1.4	1.8	5.0	1.6	-1.4	-0.2	2.2	1.2	-0.2
Shortness of breath walking on level ground	0.4	0.4	1.2	-1.1	0.2	0.9	-0.7	0.1	-0.1
Qualifications: College or University degree	0.1	0.5	1.0	-0.5	0.6	0.0	-1.0	-0.3	1.0
Eye problems/disorders: None of the above	0.4	0.4	1.0	-0.6	0.8	-0.4	-1.0	-0.3	-0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	1.3	-0.2	0.2	0.9	0.9	-0.8
Emphysema/chronic bronchitis	0.3	0.4	1.5	-0.0	0.5	1.2	-0.6	-0.2	-0.0
Medication for pain relief, constipation, heartburn	1.3	2.3	7.9	2.8	-0.7	-0.8	-0.8	1.9	0.5
Neck or shoulder pain in last month	0.4	0.6	1.4	0.7	0.4	-0.6	1.2	0.6	1.0
Medication: Blood pressure	1.8	3.2	4.9	-2.2	0.3	1.9	-1.6	-1.9	-2.1
Angina (self-reported)	1.5	2.0	7.4	-1.5	-1.2	2.7	0.1	-0.5	-0.6
Migraine (self-reported)	2.2	2.7	7.4	-0.7	2.0	0.9	0.2	-1.9	-2.7
Medication: Ibuprofen	0.3	0.3	1.6	0.3	1.2	-0.3	-0.5	0.1	-0.0
Medication: Allopurinol	0.2	0.3	0.9	0.1	0.2	-0.9	0.6	0.7	0.4
Medication: Omeprazole	0.7	0.8	1.2	-1.1	-0.7	1.1	-0.9	0.6	1.1
Medication: Seretide 50 evohaler	1.8	2.0	8.7	1.2	2.9	-0.4	-0.9	0.7	0.9
Mean time to correctly identify matches	0.6	1.2	2.1	1.4	-1.1	-1.4	-0.2	0.3	-1.4
Heart disease (mother)	0.3	0.3	1.0	-0.0	-0.4	1.0	-0.3	0.6	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	0.4	-0.5	-0.1	0.2	-0.3	0.4
Whole body fat mass	2.0	8.3	16.6	-3.9	-0.8	4.1	-1.2	-3.9	0.8
Leg fat mass (right)	2.0	7.9	15.9	-3.8	-0.8	3.8	-1.0	-4.0	1.0
Arm predicted mass (right)	1.0	5.2	12.5	-2.6	0.8	3.5	-1.0	-2.9	1.4
Pulse rate, automated reading	0.2	0.6	1.0	0.3	-0.2	0.9	-0.9	-1.0	-0.9
Alcohol intake frequency.	0.5	1.2	4.6	-0.7	-0.5	2.1	0.8	-0.8	-1.0
Comparative height size at age 10	0.1	0.5	1.7	0.3	-0.5	1.3	0.0	0.3	1.0
Number of full sisters	0.5	0.6	1.5	-0.0	1.0	1.2	-0.5	-0.7	0.4
Suffer from ‘nerves’	0.3	0.5	1.2	0.3	0.3	1.1	-1.0	-0.9	-0.2
Overall health rating	1.6	3.5	6.4	-0.3	-2.5	2.1	2.2	-1.8	-1.5
Chest pain or discomfort	4.4	6.3	17.8	-2.3	0.3	4.2	-1.2	-3.5	-1.2
Had major operations	0.3	0.3	0.9	-0.5	0.3	-0.7	0.5	0.0	1.0
Age at last live birth	0.4	0.6	1.7	0.3	1.3	-1.0	-0.6	-0.5	-0.3
Family relationship satisfaction	0.6	0.7	2.0	0.4	-0.7	1.2	-1.4	-0.5	-0.1
Leg pain on walking	0.7	0.9	3.2	-0.0	-1.1	-0.5	1.8	0.5	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.5	0.1	0.1	-1.4	2.1	-0.2	-0.2
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.1	-0.8	-1.0	-0.1	1.4	-0.0	0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.2	0.5	1.4	-1.8	1.1	-0.2	0.0
Medication: Aspirin	2.9	3.8	12.1	-3.5	-0.9	1.2	1.6	-2.4	-0.4
Supplements: Vitamin C	1.1	1.3	3.9	2.0	0.8	-0.2	-1.0	1.5	-0.4
Knee pain experienced in last month	1.0	1.5	4.0	1.0	-1.0	0.5	1.6	0.7	2.0
Hypertension (Self-reported)	3.8	10.5	27.9	-3.3	-1.1	5.3	-2.6	-3.9	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	5.2	-2.3	-0.2	0.1	1.4	-0.3	0.8
Illnesses of father: Heart disease	0.5	0.6	1.4	-1.2	-0.2	0.3	0.1	-1.2	1.0
Illnesses of siblings: Diabetes	0.4	0.5	1.6	1.3	0.5	0.9	-0.3	0.4	0.5
Smoking status: Previous	1.5	2.3	6.6	-0.3	-0.9	-1.3	2.1	0.2	2.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	5.2	-1.8	2.3	1.2	-1.1	-1.4	0.1
Whole body fat-free mass	0.6	3.7	9.5	-2.0	1.0	3.1	-1.2	-2.0	1.4
Leg fat-free mass (right)	0.8	4.4	9.8	-2.3	1.4	3.1	-1.5	-2.3	1.2
Arm fat percentage (left)	1.4	5.6	11.6	-3.1	-0.7	3.4	-1.1	-3.2	0.4
Average weekly red wine intake	1.4	2.1	4.7	1.2	-0.6	-2.2	1.2	1.4	1.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	5.3	0.3	0.2	0.2	1.3	-0.4	-2.3
Mood swings	0.4	0.8	1.9	1.4	0.4	1.4	-0.8	0.3	-0.4
Loneliness, isolation	0.4	0.6	2.4	0.1	-0.5	1.5	0.6	-0.4	0.4
Long-standing illness, disability or infirmity	0.7	1.1	4.9	0.6	-2.2	0.9	0.4	-0.1	0.2
Ever had bowel cancer screening	3.9	4.6	11.6	1.0	-2.4	-0.6	2.2	1.9	3.4
Diabetes diagnosed by doctor	1.6	2.6	9.4	-0.5	0.1	2.1	-0.2	-1.2	-3.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.1	-0.9	-0.1	1.0	-0.1	-0.5	0.4
Friendships satisfaction	1.0	1.3	2.9	-0.2	-0.6	1.4	-1.7	-0.6	-1.3
Qualifications: nursing, teaching	0.3	0.4	1.2	1.1	0.4	-0.1	-0.8	0.6	-0.2
Commuting to job workplace: Walk	0.7	0.8	2.5	-0.6	1.6	-0.7	-0.3	-0.1	1.1
Eye problems/disorders: Cataract	0.7	0.9	1.8	1.2	0.0	-0.2	0.4	1.3	1.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.9	-0.5	-1.4	0.3	0.9	-0.1	1.7
Medication for cholesterol	3.3	5.0	13.2	2.1	1.2	-3.6	0.5	3.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.8	0.4	-1.7	-0.4	1.2	-0.1	-0.9
Back pain experienced in last month	1.3	2.0	6.1	2.5	-1.1	-1.0	0.9	1.5	-0.3
Mineral and other dietary supplements	1.1	1.5	4.0	-1.3	0.5	2.0	-1.4	-0.7	-0.7
Breast cancer (self-reported)	1.0	1.2	3.4	-0.5	0.7	-1.1	1.1	0.9	1.8
Asthma (self-reported)	1.2	2.3	4.2	2.0	0.7	-2.0	1.4	1.8	-0.3
Osteoporosis (self-reported)	2.5	3.2	10.7	2.8	-0.2	-0.2	0.4	3.3	-0.1
Osteoarthritis (self-reported)	1.1	1.4	4.1	-0.2	-1.5	-1.4	2.0	-0.4	0.1
Medication: Aspirin	3.0	3.9	12.1	-3.5	-0.7	1.2	1.4	-2.8	-0.1
Medication: Gliclazide	1.1	1.3	4.6	1.1	-0.2	0.5	-0.8	1.0	-2.2
Illnesses of father: None of the above (group 1)	0.6	0.7	2.1	-0.8	-0.1	-1.4	1.2	-0.0	0.1
Smoking status: Current	0.9	1.4	3.3	1.7	-0.8	1.1	-0.3	0.7	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.3	-0.9	-1.3	2.1	-1.4	-1.0	-0.3
Whole body water mass	0.7	3.9	9.7	-2.1	1.0	3.1	-1.3	-2.2	1.3
Leg predicted mass (right)	0.8	4.3	9.6	-2.3	1.3	3.1	-1.5	-2.4	1.2
Arm fat mass (left)	1.8	7.2	14.7	-3.4	-0.4	3.8	-1.5	-3.7	0.5
Number of self-reported non-cancer illnesses	0.9	1.5	4.0	-0.8	-1.5	2.0	0.6	-1.2	0.0
Average weekly champagne plus white wine intake	0.0	0.0	0.1	0.0	-0.0	0.0	0.3	0.3	-0.2
Miserableness	0.4	0.6	2.1	1.4	0.2	0.3	1.1	0.3	0.4
Guilty feelings	0.4	0.6	1.3	0.7	0.4	1.2	-0.9	0.5	0.6
Wears glasses or contact lenses	0.3	0.4	1.4	0.3	-1.2	-0.3	0.4	0.5	0.3
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.6	-0.9	0.1	0.4	-0.7	0.1
Hearing aid user	0.8	0.9	2.1	-1.2	-0.5	0.2	1.4	-0.3	1.4
Mother’s age at death	0.5	0.7	2.5	-0.9	0.9	-1.6	-0.2	0.0	0.0
Financial situation satisfaction	0.9	1.1	3.8	-1.2	1.9	0.1	0.3	0.1	1.1
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.1	1.8	-0.7	-0.8	-0.4	1.6	0.6
Commuting to job workplace: Public transport	2.0	2.3	8.2	2.9	-1.9	-0.4	-0.1	1.2	-0.8
Eye problems/disorders: Glaucoma	0.9	1.0	3.2	0.2	-0.2	0.3	-1.8	-1.4	-1.0
Medication: Blood pressure	4.2	7.9	21.3	-3.2	-1.6	4.6	-0.6	-3.6	0.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.0	-0.1	-1.3	1.4	0.4	-0.5	-1.0
Supplements: Fish oil (including cod liver oil)	0.8	1.1	4.2	2.0	-0.8	-1.0	0.1	0.5	0.6
High cholesterol (Self-reported)	0.5	0.9	2.1	-1.4	-0.5	0.7	0.9	-0.8	-1.0
Medication: Bendroflumethiazide	1.4	2.2	5.7	-1.4	-0.5	2.4	-0.4	-2.2	-0.4
Medication: Paracetamol	0.7	1.1	3.0	-1.7	0.1	0.2	0.9	-1.7	-0.0
Medication: Lisinopril	1.1	1.4	2.5	-1.6	-0.9	1.6	-0.5	-1.5	-0.2
Medication: Atorvastatin	1.2	1.4	2.3	-1.5	-0.7	1.3	-0.0	-1.4	-1.5
Illnesses of father: High blood pressure	1.0	1.2	2.8	1.7	0.1	1.3	-1.2	1.1	0.5
Alcohol drinker status: Never	0.7	0.9	4.7	0.4	-0.1	0.5	0.2	-0.0	-2.2
Ever smoked	0.6	1.0	2.2	1.3	-0.7	-0.4	0.3	1.1	1.5
Basal metabolic rate	0.9	5.2	12.5	-2.6	0.9	3.5	-1.4	-2.6	1.4
Leg fat percentage (left)	1.4	5.1	10.4	-3.0	-1.1	3.0	-0.4	-3.2	1.0
Arm fat-free mass (left)	0.9	4.7	11.7	-2.4	0.2	3.4	-1.2	-2.7	1.3
Number of operations (self-reported)	0.3	0.5	1.2	-0.5	-1.1	0.8	-0.4	-0.8	-0.0
Average weekly beer plus cider intake	0.7	1.1	2.3	-1.4	0.4	1.5	-0.5	-1.2	-0.5
Irritability	0.4	0.8	3.1	0.1	-0.1	0.5	-1.8	-1.0	-0.3
Risk taking	2.1	3.0	10.3	-0.4	0.0	2.6	-3.2	-0.6	-0.7
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.6	0.3	1.1	-1.1	1.0	0.6	1.3
Fractured/broken bones in last 5 years	0.7	0.9	3.0	0.2	-1.7	0.9	-0.9	0.8	0.2
Age started oral contraceptive pill	1.1	1.4	4.4	-1.0	-2.1	0.1	-0.4	-1.6	-0.1
Diastolic blood pressure, automated reading	1.6	4.8	12.1	-2.3	-0.2	3.5	-2.3	-2.5	0.1
Ever depressed for a whole week	0.6	0.8	2.2	-0.4	-0.5	1.5	-0.8	-1.1	0.2
Unable to work because of sickness or disability	1.7	2.2	10.3	-1.1	-3.2	1.2	0.1	-0.6	0.5
Commuting to job workplace: Cycle	0.8	0.9	4.0	-0.8	2.0	-0.1	-0.5	-0.8	-0.1
Myopia	0.2	0.3	0.7	0.8	0.8	-0.4	-0.1	0.6	-0.4
Vascular/heart problems diagnosed by doctor	4.2	11.4	31.1	3.6	0.2	-5.6	2.7	4.0	1.0
Cholesterol lowering medication	1.8	2.7	4.4	-1.9	-1.2	1.3	2.1	-1.9	-1.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.8	-0.7	-0.2	0.7	-0.5	0.9	0.3
Pain experienced in last month	0.7	1.1	3.3	-0.4	0.9	-0.2	-1.4	-0.6	-1.8
Supplements: Calcium	0.8	0.9	1.9	0.6	-1.4	-0.4	-1.3	-0.6	-1.0
Basal cell carcinoma (self-reported)	1.0	1.1	5.0	-1.0	-0.9	-0.2	-0.4	-2.2	-0.1
Heart attack/myocardial infarction (self-reported)	2.8	3.7	7.1	-2.4	-0.4	2.7	-1.9	-1.9	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.2	-0.9	-0.7	1.0	-0.4	-1.5	-0.2
Heart disease (siblings)	0.5	0.6	1.5	-0.9	-0.5	1.2	-0.5	-0.2	-0.9
Alcohol drinker status: Previous	0.6	0.7	2.4	-0.1	-0.3	1.6	0.8	-1.0	-0.5
Pack years of smoking	2.5	3.7	6.2	-1.4	-0.6	2.5	-2.4	-1.7	-2.2
Impedance of whole body	0.2	0.9	2.1	0.8	-0.8	-1.4	0.6	0.1	-1.3
Leg fat mass (left)	2.0	7.9	15.9	-3.8	-0.7	3.8	-1.1	-4.0	0.9
Arm predicted mass (left)	0.9	4.5	10.3	-2.6	0.0	3.2	-1.0	-2.7	1.3