TWAS hub - NCF4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0263	0.0104	6.0e-03	-0.001	0.005	0.003	0.007	0.002	5.5e-01	5.8e-03	3.0e-02	0.0024	8.6e-02
2	TCGA	Breast Invasive Carcinoma	0.0609	0.0215	5.0e-06	0.051	0.027	0.041	NA	0.044	9.7e-11	2.5e-06	6.1e-09	NA	1.7e-09
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0823	0.0363	8.7e-04	0.064	0.032	0.053	NA	0.051	1.0e-07	1.4e-04	1.4e-06	NA	1.9e-06
4	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0840	0.0480	5.0e-03	0.022	0.041	0.021	NA	0.035	1.9e-02	2.2e-03	2.1e-02	NA	4.4e-03
5	TCGA	Prostate Adenocarcinoma	0.0546	0.0264	2.4e-04	0.023	0.037	0.043	NA	0.044	1.7e-03	8.5e-05	2.6e-05	NA	1.9e-05
6	TCGA	Skin Cutaneous Melanoma	0.3200	0.1260	3.9e-03	0.029	0.100	0.027	NA	0.003	5.6e-02	1.2e-03	6.4e-02	NA	2.6e-01
7	TCGA	Testicular Germ Cell Tumors	0.1780	0.0780	2.2e-03	0.025	0.022	0.012	NA	0.012	4.4e-02	5.4e-02	1.2e-01	NA	1.2e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood Eosinophil Count	10.8	83.3	141.6	-3.0	-11.2	-11.9	-10.3	-10.9	-5.3	-7.3
Crohns Disease (2017)	9.6	21.1	38.7	-0.7	-5.7	-5.7	-4.2	-6.2	-0.0	-5.0
Crohns Disease (2012)	6.1	9.9	18.9	-1.0	-4.0	-4.4	-2.5	-4.3	0.6	-2.8
Respiratory disease	6.1	13.6	23.4	-1.9	-3.8	-4.6	-3.3	-4.8	-0.8	-4.6
Allergy	6.0	13.8	22.7	2.0	3.7	4.4	3.9	4.6	0.3	4.8
Asthma (self-reported)	5.3	10.6	18.7	-1.7	-3.7	-4.3	-3.2	-4.1	-0.9	-3.3
Asthma	4.9	9.7	17.7	-1.4	-3.5	-4.2	-3.0	-4.0	-1.0	-3.1
Chronic bronchitis/emphysema (mother)	4.7	5.5	9.8	-1.8	-2.7	-3.1	-2.3	-2.4	-1.3	-2.3
Medication for hormone replacement therapy	3.9	4.4	9.4	3.1	1.7	1.1	2.7	2.1	1.4	2.0
Medication: Aspirin	3.5	4.6	9.9	1.0	3.0	3.2	1.9	2.4	0.3	1.5
Medication: Aspirin	3.3	4.4	9.7	1.3	3.0	3.1	1.9	2.3	0.0	1.2
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	6.8	-2.5	-0.7	-1.3	-2.4	-1.6	-2.2	-2.6
Hayfever, allergic rhinitis or eczema	3.0	6.4	13.6	-0.5	-2.3	-2.9	-2.6	-3.2	0.5	-3.7
Emphysema/chronic bronchitis	2.8	3.1	9.1	-1.4	-1.0	-1.4	-2.0	-1.7	-0.9	-3.0
Number of self-reported non-cancer illnesses	2.8	4.8	8.9	1.9	-1.9	-1.9	-2.4	-3.0	-0.1	-2.8
Allergy or Eczema	2.6	6.9	11.5	-0.7	-2.8	-3.3	-1.6	-3.3	2.1	-3.4
Illness, injury, bereavement, stress in last 2 years	2.6	3.2	9.1	-0.6	-0.9	-1.3	-2.2	-2.1	-0.9	-3.0
Medication: Atorvastatin	2.6	3.2	8.2	-0.0	2.9	2.6	0.6	2.5	0.8	0.4
Irritable Bowel Disease (IBD)	2.3	5.4	9.5	-0.4	-3.0	-3.1	-1.8	-2.9	0.2	-2.7
Hand grip strength (left)	2.3	6.0	11.6	0.9	2.4	2.3	3.4	2.8	1.3	3.0
Ever highly irritable/argumentative for 2 days	2.2	2.7	5.2	1.5	1.4	1.6	2.3	1.7	0.4	2.0
Neuroticism (2016)	2.1	3.1	6.0	-0.2	-2.3	-2.5	-1.8	-1.8	-1.5	-1.2
Lupus	2.0	3.1	5.4	0.2	-1.4	-1.7	-2.1	-2.0	-1.7	-2.3
Prospective memory result	2.0	2.4	4.2	-0.9	1.7	2.0	1.6	1.6	1.6	1.2
Ulcerative Colitis	1.9	2.7	7.2	1.4	0.9	1.3	2.7	2.1	1.4	1.2
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	2.8	1.5	1.5	1.7	1.4	1.5	0.9	1.6
Number of children fathered	1.9	2.1	3.7	1.9	0.7	1.1	1.1	1.2	1.8	1.9
Ever used hormone-replacement therapy (HRT)	1.7	2.1	4.1	0.8	1.5	1.7	1.8	2.0	0.9	0.8
Hand grip strength (right)	1.7	4.6	8.1	0.8	2.3	2.2	2.6	2.5	0.1	2.8
Alcohol intake versus 10 years previously	1.7	2.6	5.7	-2.3	-0.3	-0.8	-1.5	-1.4	-2.4	-1.5
Hearing difficulty/problems: Yes	1.6	2.4	3.9	1.7	1.6	2.0	1.9	1.5	1.0	0.8
Medication: Ventolin 100micrograms inhaler	1.6	2.1	3.5	0.0	-1.8	-1.9	-1.1	-1.8	0.3	-1.9
Cholesterol lowering medication	1.6	2.3	5.4	-2.2	2.3	2.1	-0.1	1.2	-0.3	-0.3
Serious illness, injury or assault to yourself	1.5	1.8	3.4	1.1	1.6	1.8	1.2	1.2	-0.8	1.4
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.3	1.6	-0.7	0.1	1.9	0.4	0.3	2.3
Medication for cholesterol	1.5	2.3	6.2	-0.2	-2.5	-1.8	-1.5	-1.8	-0.7	-0.9
Average weekly spirits intake	1.4	1.8	3.3	0.9	1.8	1.8	1.3	1.3	0.9	1.1
Diabetes (father)	1.4	1.8	3.4	0.9	0.9	1.4	1.8	1.5	1.1	1.5
Lung cancer (father)	1.4	1.7	3.9	-0.7	-2.0	-1.8	-0.3	-1.3	-1.2	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	3.8	1.9	0.8	1.0	1.9	1.0	0.4	1.4
Age when periods started (menarche)	1.3	3.2	6.4	-1.0	-2.5	-2.3	-2.3	-1.9	0.1	-0.8
Friendships satisfaction	1.3	1.6	4.1	-0.1	1.5	2.0	1.2	1.0	0.7	1.3
Severe depression (siblings)	1.2	1.4	2.1	0.9	-1.2	-1.5	-1.4	-0.7	-0.8	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.8	4.1	2.0	1.2	1.3	1.4	1.2	-0.5	1.2
Father’s age at death	1.2	1.6	3.3	0.3	-0.4	-0.9	-1.8	-1.1	-1.6	-1.8
Exposure to tobacco smoke at home	1.2	1.3	2.5	1.5	0.5	0.6	1.6	0.6	1.5	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.1	1.6	1.3	2.0	1.6	1.1	-0.9	0.3
Wheeze or whistling in the chest in last year	1.2	2.1	4.1	-0.5	-1.4	-1.8	-1.5	-1.6	-0.6	-2.0
Pulse wave peak to peak time	1.2	1.4	6.9	2.6	0.4	0.5	0.4	0.2	1.6	0.1
Hearing aid user	1.2	1.3	4.3	-0.0	1.1	1.2	0.6	1.3	2.1	0.0
Ever smoked	1.2	2.1	7.0	-0.6	2.6	2.3	0.5	0.9	-0.7	-0.9
Risk taking	1.2	1.8	4.5	-0.4	-1.3	-1.0	-1.8	-2.1	0.4	-1.2
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.3	1.4	1.4	1.1	1.5	1.3	-1.5	0.9
Mouth/teeth dental problems: Dentures	1.1	1.8	7.3	0.2	0.3	1.1	0.9	0.8	2.7	1.6
Pulse wave Arterial Stiffness index	1.1	1.3	6.4	-2.5	-0.0	-0.1	-0.0	0.1	-1.7	0.1
Leg pain on walking	1.1	1.4	3.9	-2.0	0.8	0.9	1.2	0.8	-0.8	1.2
Average weekly red wine intake	1.1	1.6	5.1	0.2	2.3	2.1	0.4	1.2	0.2	-0.0
Alcohol drinker status: Never	1.1	1.4	6.2	1.6	-0.4	0.1	0.7	0.1	2.5	0.5
Age started oral contraceptive pill	1.1	1.4	2.9	-0.7	-1.0	-1.7	-1.2	-0.8	-0.7	-1.7
Myopia	1.1	1.6	3.4	-0.5	1.8	1.2	-0.6	0.4	-1.8	-1.4
Number of incorrect matches in round	1.0	1.6	2.8	-0.7	-1.3	-1.7	-1.7	-1.2	-0.4	-1.5
Length of working week for main job	1.0	1.1	6.6	-0.5	0.2	-0.3	-0.4	-0.5	-2.6	-0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.3	-0.8	-0.8	-1.0	-1.5	-1.1	-1.1	-2.1
Gout (self-reported)	1.0	1.4	2.6	1.0	-1.0	-0.9	-1.4	-1.6	0.8	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.7	1.9	0.8	1.5	0.6	0.4	-1.1	0.6
Age at first live birth	1.0	1.7	3.3	1.8	0.8	1.4	0.8	1.2	1.6	1.2
Schizophrenia vs Biploar Disorder	0.9	1.2	6.6	2.6	0.0	0.0	0.0	0.0	1.3	0.0
Age at First Birth	0.9	1.4	3.0	0.8	1.1	1.7	0.8	1.2	1.1	1.1
Body Mass Index (BMI) (2010)	0.9	1.3	2.7	-1.6	-1.1	-0.8	0.7	0.2	1.0	1.6
Rheumatoid Arthritis	0.9	1.2	3.4	0.6	1.1	1.0	-0.4	0.2	1.8	-1.5
Relative age voice broke	0.9	1.4	2.6	1.4	-1.0	-0.7	-1.6	-1.4	-1.0	-0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.3	-2.1	-1.0	-1.7	-0.7	-1.0	-1.0	-0.2
Neck or shoulder pain in last month	0.9	1.3	3.3	0.5	1.1	1.3	1.4	0.9	1.8	0.2
Medication: Blood pressure	0.9	1.5	4.3	2.1	1.0	1.6	0.6	1.1	1.1	0.5
Medication: Omeprazole	0.9	1.0	3.3	-1.8	0.1	0.5	-1.2	-0.5	-1.2	-0.8
Supplements: Vitamin C	0.9	1.1	2.8	1.7	0.6	0.6	1.3	1.0	1.2	0.4
Average weekly beer plus cider intake	0.9	1.3	3.5	0.5	-1.9	-1.7	-0.4	-1.2	-0.9	-0.2
Pain experienced in last month	0.9	1.5	3.9	0.7	-0.6	-0.8	-2.0	-1.4	-0.6	-1.6
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.0	-0.0	0.7	1.4	1.0	1.1	0.4	1.7
Primary Biliary Cirrhosis	0.8	1.2	2.3	0.4	1.2	1.5	1.1	0.9	1.4	0.6
Hypothyroidism (self reported)	0.8	1.8	3.9	1.5	1.3	2.0	1.2	0.8	1.1	1.3
Sensitivity / hurt feelings	0.8	1.4	5.0	2.0	0.2	-0.2	-0.0	-0.6	-2.2	-0.9
Townsend deprivation index at recruitment	0.8	1.1	2.3	1.5	-0.4	-0.6	0.1	-1.1	-1.1	-1.5
Past tobacco smoking	0.8	1.5	3.4	1.3	-1.8	-1.8	0.0	-0.4	0.7	1.1
Hearing difficulty/problems with background noise	0.8	1.2	2.7	1.7	1.2	1.1	1.3	1.2	0.0	0.3
Had menopause	0.8	1.0	6.2	-2.5	-0.2	-0.5	-0.5	-0.0	-0.3	-0.6
Heart attack	0.8	1.1	2.6	0.1	0.7	1.5	1.0	1.0	0.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	3.2	0.4	0.4	0.8	1.1	0.9	0.1	1.8
Depression (self-reported)	0.8	0.9	6.0	2.5	0.4	0.1	0.2	0.0	-0.0	-0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	4.8	2.2	0.7	1.4	1.0	0.5	1.2	0.9
Comparative body size at age 10	0.8	2.2	3.8	-0.9	2.0	1.8	1.2	1.9	-1.4	0.8
Worry too long after embarrassment	0.8	1.3	7.5	0.5	0.9	0.7	-0.5	0.4	-2.7	0.2
Medication for pain relief, constipation, heartburn	0.8	1.4	4.8	-0.1	-1.6	-2.2	-1.1	-1.2	0.1	-0.4
Angina (self-reported)	0.8	1.1	3.2	-1.5	0.3	0.2	-1.1	-0.1	-1.8	-0.9
Medication: Seretide 50 evohaler	0.8	0.9	4.0	-0.3	0.2	0.1	0.7	0.8	2.0	0.9
Had major operations	0.8	1.0	3.0	0.7	1.2	0.3	-0.3	0.3	-1.7	-1.3
Mood swings	0.8	1.5	2.8	0.4	-1.1	-1.4	-0.9	-1.4	-1.7	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.9	1.3	-0.3	-0.3	0.7	-0.5	1.7	-0.6
Fractured/broken bones in last 5 years	0.8	1.0	3.7	-1.4	-0.2	-0.1	-0.9	-0.7	0.1	-1.9
Bipolar Disorder (2018)	0.7	1.1	3.9	-1.4	0.3	0.0	-1.0	-0.3	-2.0	-1.0
LDL Cholesterol	0.7	1.0	2.5	-0.9	1.6	1.5	0.2	1.2	0.0	0.1
Ever had hysterectomy (womb removed)	0.7	0.8	2.2	0.6	1.2	1.5	-0.1	0.4	-0.1	-1.2
Angina	0.7	0.9	2.3	-1.2	0.2	0.1	-1.2	-0.2	-1.5	-0.9
Hair/balding pattern: Pattern 2	0.7	0.8	3.3	0.6	-0.1	-0.3	-1.1	-1.0	0.1	-1.8
Mouth/teeth dental problems	0.7	1.1	3.1	0.7	-0.0	-0.9	-0.5	-1.1	-1.8	-1.5
Medication: Lansoprazole	0.7	0.8	1.4	-0.1	1.2	1.1	-0.9	0.3	-1.0	-0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.8	-0.4	-1.2	-1.3	-1.4	-0.9	-0.6	-0.5
Age at last live birth	0.7	1.0	2.7	1.5	0.1	0.9	0.5	0.5	1.6	0.8
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.3	1.0	0.5	0.2	1.2	1.1	-0.1	1.5
Medication: Gliclazide	0.7	0.8	1.5	-0.8	-1.2	-1.0	-0.7	-1.0	-1.1	-0.4
Commuting to job workplace: Public transport	0.7	0.8	1.9	1.0	0.9	0.7	1.0	0.5	1.4	0.0
Ever depressed for a whole week	0.7	0.9	1.9	0.1	0.1	1.0	1.2	0.9	1.4	1.0
Commuting to job workplace: Cycle	0.7	0.9	2.6	1.6	0.0	0.9	1.3	0.5	0.3	1.0
Alzheimer’s Disease (in father)	0.6	0.7	1.4	0.5	1.2	0.8	0.4	1.0	1.1	-0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.1	1.8	-0.4	-0.0	1.1	-0.0	-0.5	0.9
Vitamin and mineral supplements	0.6	0.8	1.7	-0.6	0.5	0.6	0.5	1.2	1.2	1.3
Medication: Metformin	0.6	0.9	2.8	-0.9	0.0	0.6	0.6	0.7	-1.2	1.7
Time employed in main current job	0.6	0.7	1.4	-0.4	1.2	1.2	0.8	0.7	0.6	0.5
Pulse rate	0.6	1.0	3.2	-1.8	-0.8	-0.8	-0.9	-0.8	-0.8	0.5
Medication: Cholesterol lowering	0.6	0.9	3.3	1.8	0.8	1.1	0.2	0.6	1.1	0.2
Loud music exposure frequency	0.6	0.7	2.0	-0.6	-0.1	0.3	1.2	0.4	-0.7	1.4
Health satisfaction	0.6	0.8	1.4	-0.1	-1.1	-0.9	-0.4	-1.2	-0.8	-1.2
Shortness of breath walking on level ground	0.6	0.7	2.1	-0.1	0.6	0.9	1.4	0.9	-0.5	0.5
Comparative height size at age 10	0.6	3.5	9.0	0.3	3.0	2.3	2.3	2.2	0.3	0.3
Chest pain or discomfort	0.6	0.9	2.4	1.2	0.8	1.5	0.5	0.8	1.1	0.3
Smoking status: Previous	0.6	0.8	3.0	-0.5	1.4	1.7	0.4	0.6	0.2	-0.2
Qualifications: nursing, teaching	0.6	0.9	1.4	0.9	1.0	0.2	1.1	1.1	-1.2	0.8
Osteoarthritis (self-reported)	0.6	0.7	4.1	0.2	-0.2	-0.2	0.7	-0.5	2.0	-0.3
Smoking status: Current	0.6	0.9	4.0	-0.1	1.1	0.8	0.4	0.5	-2.0	-0.3
Miserableness	0.6	1.0	6.0	-0.2	-0.2	-0.3	-0.4	-0.2	-2.4	-0.6
Mother’s age at death	0.6	0.7	2.2	0.2	-0.1	-0.1	-1.0	-1.1	0.6	-1.5
Financial situation satisfaction	0.6	0.7	2.0	0.6	0.1	1.4	0.6	0.0	1.3	0.6
Supplements: Calcium	0.6	0.6	1.7	1.3	0.0	0.3	-0.8	-0.6	-0.7	-1.1
Intelligence (Savage-Jansen 2018)	0.5	1.4	5.0	1.2	-0.8	-1.0	-0.8	-0.9	-2.2	-0.6
Alzheimer’s Disease (in mother)	0.5	0.5	1.6	-0.1	-1.3	-0.6	-0.1	-0.5	-0.7	1.0
Ulcerative Colitis (UC)	0.5	0.9	2.3	-0.1	0.7	0.7	1.5	1.5	0.7	0.7
Smoking Status	0.5	1.2	3.0	0.1	1.7	1.7	0.6	1.0	-1.1	-0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.3	1.1	0.4	0.9	0.5	0.4	1.1	1.0
Medication: Co-codamol	0.5	0.6	1.8	-0.0	1.0	0.6	-0.1	0.5	0.7	-1.3
Diabetes (mother)	0.5	0.6	1.0	-1.0	1.0	0.7	0.9	1.0	0.3	0.2
Current tobacco smoking	0.5	0.8	2.1	0.2	1.2	0.8	0.8	0.9	-1.4	0.2
Average weekly fortified wine intake	0.5	0.6	1.2	-1.1	0.9	0.8	0.1	0.4	-0.2	-1.0
Qualifications: CSEs or equivalent	0.5	0.6	1.2	0.5	-0.9	-0.7	-0.8	-0.7	-0.7	-1.1
Chronic bronchitis/emphysema (father)	0.5	0.5	1.2	-0.6	-0.7	-1.1	-0.8	-0.2	-0.7	-0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.5	0.7	0.2	0.3	1.6	0.4	-0.3	0.9
Medication: Ramipril	0.5	0.7	1.5	-0.7	-0.8	-0.5	-1.2	-0.8	-0.6	-1.0
Neuroticism score	0.5	0.9	5.4	0.9	0.1	-0.5	0.0	-0.2	-2.3	0.2
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	0.1	0.8	0.6	1.0	1.1	1.3	0.7
Breastfed as a baby	0.5	0.6	1.3	0.9	0.9	1.1	0.6	0.4	1.0	0.2
Glaucoma (self-reported)	0.5	0.6	1.4	0.3	0.8	1.2	0.7	0.9	-0.6	0.5
Arm fat-free mass (right)	0.5	2.6	6.6	0.1	2.6	2.5	1.4	1.7	0.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.3	1.5	0.5	0.6	0.3	0.5	0.8	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.4	-0.6	0.5	0.7	0.6	0.7	-0.1	1.5
Mean time to correctly identify matches	0.5	0.9	3.8	-1.9	0.2	0.0	-0.5	0.0	0.3	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	1.4	-1.1	-0.6	0.1	-0.5	0.1	-0.1
Arm predicted mass (right)	0.5	2.5	6.3	-0.0	2.5	2.5	1.4	1.7	0.3	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.6	-1.0	-0.4	-0.1	-1.3	-0.5	-0.9	0.3
Hypertension (Self-reported)	0.5	1.4	3.6	1.0	1.4	1.3	0.5	1.0	1.9	0.2
Illnesses of siblings: Diabetes	0.5	0.7	1.0	0.9	0.5	0.9	0.8	1.0	0.2	0.9
Loneliness, isolation	0.5	0.6	3.6	-0.1	-0.6	-0.5	0.4	-0.1	-1.9	0.3
Long-standing illness, disability or infirmity	0.5	0.8	3.5	1.3	-0.3	0.3	0.5	-0.3	1.9	-0.3
Eye problems/disorders: Cataract	0.5	0.6	1.3	1.0	0.7	0.6	0.8	1.1	-0.3	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.2	-0.1	0.8	0.9	-0.1	0.5	-1.5	-0.3
Average weekly champagne plus white wine intake	0.5	0.7	1.9	0.8	-0.6	-0.6	-1.1	-0.7	-0.3	-1.4
Unable to work because of sickness or disability	0.5	0.6	1.4	0.1	-1.2	-0.4	-1.0	-1.0	0.7	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.7	-0.2	-0.5	-0.4	-0.3	-0.5	1.6	-0.9
Major Depression (MDD)	0.4	0.4	0.7	-0.8	-0.9	0.0	-0.2	-0.7	-0.8	-0.7
Verbal and Numeric Reasoning (VNR)	0.4	1.0	4.6	-0.4	-0.6	-1.0	-0.6	-0.4	-2.1	-0.5
Schizophrenia (2014)	0.4	0.9	3.1	-1.8	1.1	0.5	0.6	0.7	0.2	-1.0
Triglycerides	0.4	0.7	1.6	-0.0	-0.9	-0.9	0.7	0.2	1.3	1.0
Waist Hip Ratio (WHR)	0.4	2.0	4.8	0.1	1.8	2.2	0.9	1.4	-1.2	1.2
Cardiovascular Disease	0.4	1.2	2.0	0.4	1.1	1.4	1.2	1.0	1.0	1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	3.0	-1.7	-0.3	0.5	-1.1	0.1	-0.5	-0.5
Number of treatments/medications taken	0.4	0.7	1.6	1.2	0.8	1.1	0.0	0.4	1.3	-0.4
Leg fat-free mass (left)	0.4	1.9	5.5	-0.5	2.3	2.1	0.9	1.5	-0.6	0.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	1.8	-1.0	-0.2	-0.4	-0.4	-0.0	-1.3	-0.3
Multivitamins +/- minerals	0.4	0.5	1.2	-0.7	0.0	-0.2	-0.5	-0.9	-0.9	-1.1
Medication: Atenolol	0.4	0.5	2.1	-0.1	0.6	0.6	-0.5	-0.2	-1.5	-0.5
Medication: Simvastatin	0.4	0.5	1.3	-0.8	0.4	0.4	-1.1	-0.5	0.6	-1.0
Falls in the last year	0.4	0.5	1.4	0.4	0.5	0.7	1.2	0.7	0.9	0.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.7	0.4	1.2	0.6	0.9	1.0	-1.6	0.3
Headache pain in last month	0.4	0.7	2.2	-0.8	0.7	0.4	1.1	0.7	-0.3	1.5
Number of full brothers	0.4	0.6	2.4	0.2	0.3	0.6	0.3	0.9	-1.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-1.1	-0.3	-0.2	-0.9	-0.4	-1.1	-0.4
Leg fat-free mass (right)	0.4	2.3	6.7	-0.0	2.6	2.3	1.1	1.7	-0.3	0.3
Commuting to job workplace: Walk	0.4	0.5	0.9	0.7	-0.6	-0.8	-0.9	-0.5	0.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.8	-0.4	1.1	1.3	-0.2	0.9	0.2	-0.1
Breast cancer (self-reported)	0.4	0.5	2.0	-0.1	0.8	0.7	-0.6	-0.2	0.5	-1.4
Osteoporosis (self-reported)	0.4	0.5	1.3	0.6	-0.8	-0.5	-0.5	-1.2	-0.2	-0.6
Leg predicted mass (right)	0.4	2.3	6.6	-0.0	2.6	2.3	1.1	1.7	-0.3	0.3
Guilty feelings	0.4	0.6	1.2	0.8	0.8	0.7	1.1	0.7	0.1	0.8
Ever taken oral contraceptive pill	0.4	0.4	0.7	-0.8	0.7	0.6	0.1	0.6	-0.8	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.6	-0.8	-1.0	-0.9	-0.8	-0.4	-0.3
High cholesterol (Self-reported)	0.4	0.6	1.8	1.0	1.2	1.4	-0.3	0.2	0.3	-0.4
Illnesses of father: High blood pressure	0.4	0.5	1.0	-0.5	1.0	0.8	0.7	0.9	0.2	0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	0.8	1.1	1.1	0.4	0.3	-0.2	-0.1
Heart disease (siblings)	0.4	0.5	1.0	0.1	0.5	0.7	1.0	1.0	-0.6	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	3.2	-1.8	0.4	-0.2	-0.4	-0.0	-0.6	-1.3
Depressed Affect (Nagel 2018)	0.3	0.6	3.0	-0.8	-0.4	-0.2	-0.0	-0.2	-1.7	0.5
Depression (Nagel 2018)	0.3	0.4	1.2	0.3	0.1	0.6	1.1	0.3	-0.6	0.9
Coronary Artery Disease (CAD)	0.3	0.4	2.5	0.1	0.0	0.0	0.0	0.0	1.6	0.0
Mean Putamen Volume	0.3	0.3	0.9	-0.2	-0.4	-0.7	0.6	0.5	0.4	0.9
Fasting Glucose	0.3	0.3	1.2	0.2	-0.6	-1.1	-0.1	0.1	0.6	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	-0.4	-0.4	-0.5	0.9	0.4	0.7	-0.1
Blood Red Count	0.3	3.1	6.9	1.8	0.9	0.8	2.0	2.1	-1.4	2.6
BMI	0.3	1.7	5.9	-2.4	1.1	1.6	0.6	0.9	0.2	1.0
Neuroticism	0.3	0.7	3.4	0.8	-0.3	-0.3	-0.4	-0.3	-1.8	0.4
Chronotype (morning person)	0.3	0.6	1.1	-0.5	-1.0	-1.0	-0.4	-0.9	0.8	0.6
Systolic blood pressure, automated reading	0.3	0.8	1.8	-0.0	-1.3	-1.1	-0.4	-0.7	1.4	-0.1
High blood pressure	0.3	0.8	1.8	0.8	1.2	1.1	0.2	0.8	1.3	0.2
Stomach or abdominal pain in last month	0.3	0.4	0.9	0.8	0.2	0.0	1.0	0.5	-0.6	0.7
Medication: Levothyroxine sodium	0.3	0.6	3.2	1.8	0.0	0.5	0.0	-0.4	0.5	0.1
Leg predicted mass (left)	0.3	1.8	5.2	-0.6	2.3	2.0	0.9	1.4	-0.7	0.2
Qualifications: None of the above	0.3	0.6	2.9	0.4	-0.6	0.2	0.7	-0.2	1.7	0.8
Pain all over the body in last month	0.3	0.3	1.2	0.1	-0.1	0.3	0.0	0.4	-1.1	1.0
Diabetes (self-reported)	0.3	0.5	1.2	-0.3	0.1	0.9	0.1	0.6	1.1	1.0
Trunk fat-free mass	0.3	1.5	4.9	-0.2	2.2	1.9	0.8	1.1	-0.1	0.1
Worrier / anxious feelings	0.3	0.5	1.4	1.2	-0.5	-0.5	-0.0	-0.3	-0.6	1.0
Happiness	0.3	0.4	1.7	1.3	-0.3	-0.0	0.6	-0.3	-0.5	0.3
Illnesses of mother	0.3	0.4	1.3	1.1	0.4	0.5	0.7	0.2	0.3	0.4
Trunk predicted mass	0.3	1.4	4.7	-0.1	2.2	1.8	0.9	1.1	0.1	0.2
Standing height	0.3	2.7	6.7	1.4	2.6	2.1	1.7	1.5	0.6	0.2
Pulse wave reflection index	0.3	0.4	0.9	0.6	0.6	0.4	1.0	0.9	-0.3	-0.2
Qualifications: College or University degree	0.3	0.9	2.5	0.6	1.2	0.5	0.9	1.0	-1.6	0.4
Eye problems/disorders: None of the above	0.3	0.3	0.8	-0.9	0.8	0.6	-0.1	0.0	0.3	-0.6
Medication: Allopurinol	0.3	0.4	0.9	-0.4	-0.7	-0.8	-0.9	-0.8	0.3	-0.4
Pulse rate, automated reading	0.3	0.9	5.0	-2.2	-0.4	-0.3	-0.9	-0.5	0.0	0.3
Suffer from ‘nerves’	0.3	0.4	2.0	1.4	-0.3	-0.3	-0.1	-0.2	-0.9	0.3
Family relationship satisfaction	0.3	0.4	0.9	0.7	-0.4	0.2	0.8	-0.5	-0.6	1.0
Whole body fat-free mass	0.3	1.7	5.2	-0.2	2.3	2.0	0.9	1.3	-0.2	0.3
Ever had bowel cancer screening	0.3	0.4	1.4	-1.2	-0.2	-0.3	0.3	-0.3	0.9	-0.3
Diabetes diagnosed by doctor	0.3	0.5	1.8	-1.4	0.2	0.9	-0.3	0.6	0.2	0.5
Mineral and other dietary supplements	0.3	0.5	0.8	0.4	0.6	0.7	0.9	0.9	0.6	0.5
Whole body water mass	0.3	1.7	5.3	-0.2	2.3	2.1	0.9	1.3	-0.2	0.3
Wears glasses or contact lenses	0.3	0.3	0.8	-0.9	0.5	0.5	0.0	0.4	0.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.1	-0.2	-0.2	-0.4	0.4	0.4	-1.0	0.8
Medication: Bendroflumethiazide	0.3	0.4	1.1	-0.6	0.8	1.1	0.1	0.7	0.2	-0.0
Basal metabolic rate	0.3	1.7	5.0	-0.3	2.2	2.1	0.9	1.3	-0.4	0.2
Number of operations (self-reported)	0.3	0.4	1.1	-0.1	1.1	0.5	0.6	0.1	-1.0	-0.5
Irritability	0.3	0.5	2.2	0.5	-0.4	-0.5	-0.8	-0.2	-1.5	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.2	-1.1	0.1	0.3	-0.7	-0.1	-1.0	-0.3
Neuroticism (Nagel 2018)	0.2	0.5	2.5	0.7	-0.2	-0.2	-0.0	0.1	-1.6	0.9
Schizophrenia (2018)	0.2	0.4	1.3	-1.1	0.3	-0.3	0.3	0.2	0.8	-0.9
Worry (Nagel 2018)	0.2	0.4	1.3	0.9	0.0	0.1	0.2	0.3	-0.8	1.2
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.5	-0.9	-0.3	-0.6	-0.6	0.1	-0.3
Reaction Time	0.2	0.4	1.3	-1.1	-0.7	-0.6	-0.2	-0.5	0.2	-0.7
Ovarian Cancer	0.2	0.2	0.7	-0.2	0.5	0.3	0.1	0.5	-0.9	0.2
HbA1C	0.2	0.3	0.9	0.8	0.0	0.4	0.5	-0.3	0.9	0.0
Blood White Count	0.2	1.6	5.2	0.1	-2.3	-1.2	-0.5	-1.7	0.8	-0.7
Systolic Blood Pressure	0.2	1.0	2.5	1.1	-1.6	-1.3	-0.3	-1.1	0.8	0.2
Lung FEV1/FVC ratio	0.2	0.8	3.3	0.5	1.2	1.8	0.0	0.8	-0.4	-0.0
Lung FVC	0.2	1.0	5.6	-2.4	0.9	0.2	-0.3	0.4	0.2	-0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.8	0.3	-0.6	0.2	0.3	0.1	0.5	0.9
Supplements: Zinc	0.2	0.2	0.9	-0.9	-0.4	-0.6	0.2	-0.0	-0.1	-0.4
Pack years adult smoking proportion	0.2	0.3	1.1	-0.0	-0.1	0.4	1.0	0.3	0.8	0.5
Impedance of leg (right)	0.2	0.8	2.7	0.4	-1.7	-1.3	-0.3	-1.0	0.3	-0.1
Maternal smoking around birth	0.2	0.3	0.6	-0.7	-0.5	-0.5	0.3	0.4	0.8	0.3
Taking other prescription medications	0.2	0.3	0.8	0.8	0.1	-0.0	-0.6	-0.4	0.3	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	0.6	-1.0	-0.7	-0.0	-0.4	0.9	0.4
Impedance of leg (left)	0.2	0.9	1.8	1.3	-1.3	-0.9	-0.0	-0.7	1.1	0.1
Trunk fat mass	0.2	0.8	2.8	-0.5	1.1	1.7	0.1	0.6	-0.7	-0.4
Waist circumference	0.2	0.8	2.5	-0.9	1.0	1.6	0.1	0.5	-0.9	0.0
Had other major operations	0.2	0.2	0.9	-1.0	0.1	-0.2	0.5	-0.3	0.1	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.4	-0.1	-0.3	-0.1	-0.6	-0.6	1.2	-0.6
Financial difficulties in last 2 years	0.2	0.3	0.9	0.9	-0.3	0.5	0.5	-0.0	0.2	0.5
Fluid intelligence score	0.2	0.5	2.4	0.4	-0.4	-0.8	-0.2	-0.1	-1.6	-0.1
Weight	0.2	1.2	3.5	-0.7	1.7	1.9	0.6	1.0	-0.4	0.1
Impedance of arm (right)	0.2	0.8	1.5	0.9	-1.0	-1.2	-0.7	-1.0	-0.1	-1.0
Arm fat percentage (right)	0.2	0.7	2.4	-1.2	0.2	0.6	-0.7	-0.2	-1.5	-0.7
Number of live births	0.2	0.3	0.8	-0.0	-0.6	-0.3	0.9	0.0	0.8	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	0.2	-0.2	-0.1	0.2	-0.3	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	2.2	-0.3	1.5	1.1	0.5	0.5	-0.2	0.1
Arm fat mass (right)	0.2	0.8	1.8	-1.0	1.0	1.3	-0.0	0.4	-1.3	-0.2
Tense / ‘highly strung’	0.2	0.4	1.5	-0.6	-0.4	-0.8	-0.4	-0.1	-1.2	0.1
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	0.3	-1.0	-1.0	-0.3	-0.5	-0.9	0.3
Peak expiratory flow (PEF)	0.2	0.5	2.1	1.4	0.8	0.6	0.5	0.5	0.3	0.0
Blood clot in the leg (DVT)	0.2	0.2	1.0	-1.0	0.2	0.3	0.2	0.5	-0.2	0.3
Medication: Paracetamol	0.2	0.3	0.8	-0.9	0.3	0.8	0.3	0.4	0.8	0.2
Medication: Amlodipine	0.2	0.3	0.7	0.5	-0.4	-0.4	-0.5	-0.6	0.8	-0.5
Birth weight	0.2	0.4	1.2	-0.1	1.1	0.4	0.3	0.9	-0.7	0.0
High blood pressure (siblings)	0.2	0.3	0.5	-0.2	-0.7	-0.3	-0.7	-0.7	-0.5	-0.5
Leg fat percentage (right)	0.2	0.6	3.2	-1.8	-0.3	0.5	-0.3	-0.1	-0.6	0.0
Migraine (self-reported)	0.2	0.3	0.6	-0.0	0.3	0.8	0.5	0.4	-0.7	0.5
Heart disease (mother)	0.2	0.2	0.9	-0.6	0.2	-0.0	0.2	0.4	-0.9	0.1
Whole body fat mass	0.2	0.9	3.0	-0.8	1.2	1.7	0.4	0.8	-0.6	0.1
Leg fat mass (right)	0.2	0.8	1.9	-1.1	0.9	1.4	0.6	0.8	-0.3	0.6
Overall health rating	0.2	0.4	1.4	-0.1	1.2	0.8	0.0	0.7	-0.5	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.7	-0.3	0.3	0.6	-0.3	0.0	-0.9	0.3
Illnesses of father: Heart disease	0.2	0.3	1.2	0.1	0.1	0.6	0.6	-0.0	-0.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	0.9	-0.5	-0.5	0.2	-0.3	-1.1	-0.4
Arm fat percentage (left)	0.2	0.8	2.4	-1.3	0.2	0.6	-0.7	-0.2	-1.5	-0.7
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	0.4	-0.8	-0.3	-0.2	-0.9	-0.2	-0.3
Arm fat mass (left)	0.2	0.8	2.2	-1.2	0.8	1.2	-0.1	0.3	-1.5	-0.3
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.0	0.6	0.1	0.2	0.2	0.2	0.7	-1.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.7	0.7	-0.3	0.1	0.6	0.4	-0.0	0.8
Medication: Paracetamol	0.2	0.2	0.8	-0.4	0.1	0.7	-0.4	0.1	0.9	-0.3
Medication: Lisinopril	0.2	0.3	1.2	-0.4	1.1	0.8	-0.1	0.5	-0.1	-0.1
Arm fat-free mass (left)	0.2	1.1	3.0	-0.2	1.7	1.7	0.8	0.9	-0.1	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.2	-0.5	-1.1	-0.9	0.1	-0.7	-0.9	0.1
Alcohol drinker status: Previous	0.2	0.3	0.5	-0.6	-0.7	-0.5	-0.4	-0.3	0.5	0.4
Arm predicted mass (left)	0.2	1.2	3.2	-0.3	1.8	1.8	0.8	1.0	-0.3	0.5
Breast Cancer	0.1	0.2	0.9	0.9	-0.7	0.2	-0.1	-0.2	0.2	-0.0
Prostate Cancer	0.1	0.1	0.3	-0.1	0.2	-0.4	0.6	0.4	0.3	-0.4
HDL Cholesterol	0.1	0.2	0.6	-0.2	0.2	0.5	0.2	0.6	-0.8	0.4
Blood Platelet Count	0.1	0.6	1.2	1.0	-0.7	-0.1	-0.7	-1.1	1.0	-0.3
Hair Pigment	0.1	2.2	3.2	-0.8	1.6	1.8	1.7	1.8	1.4	1.0
Tanning	0.1	0.8	4.0	0.4	-0.5	-0.4	0.8	0.2	2.0	0.2
Relative age of first facial hair	0.1	0.3	1.3	0.1	0.6	0.3	-0.4	0.3	-1.2	-0.2
Trunk fat percentage	0.1	0.5	1.7	-0.6	0.6	1.3	-0.2	0.2	-0.8	-0.6
Fed-up feelings	0.1	0.3	1.0	-0.5	-0.2	-0.6	0.4	-0.3	-1.0	-0.1
Supplements: Glucosamine	0.1	0.1	0.2	0.1	-0.5	-0.4	0.4	-0.3	0.3	-0.0
Sitting height	0.1	0.6	1.1	0.9	1.0	0.7	1.0	0.5	0.8	0.3
High blood pressure (mother)	0.1	0.1	0.3	-0.1	0.5	0.1	0.5	0.1	-0.3	0.3
Body mass index (BMI)	0.1	0.6	2.2	-1.5	0.6	1.0	-0.2	0.4	-0.8	-0.1
Alcohol usually taken with meals	0.1	0.2	0.6	-0.1	-0.0	-0.2	-0.8	-0.8	0.3	-0.5
Nervous feelings	0.1	0.2	0.5	0.7	0.4	-0.1	0.7	0.1	-0.5	-0.0
Illnesses of siblings	0.1	0.1	0.6	0.1	-0.0	-0.8	-0.2	-0.5	0.2	-0.1
Hip circumference	0.1	0.3	0.8	-0.4	0.7	0.9	-0.2	-0.1	-0.7	-0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.5	0.7	1.2	1.0	0.4	0.5	-0.1	0.1
Noisy workplace	0.1	0.1	0.6	-0.3	-0.0	-0.4	0.8	-0.3	0.3	0.2
Impedance of arm (left)	0.1	0.6	1.5	0.6	-0.7	-0.8	-0.6	-0.8	-0.3	-1.2
Birth weight of first child	0.1	0.2	0.5	0.7	-0.1	-0.1	0.6	0.3	0.6	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.3	0.9	-0.7	1.0	0.5	0.4	0.2	-0.1	-0.0
Body fat percentage	0.1	0.5	1.1	-1.1	0.3	1.0	-0.3	0.0	-0.8	-0.5
Medication: Ibuprofen	0.1	0.2	0.5	0.6	-0.4	-0.2	0.1	-0.2	-0.1	-0.7
Alcohol intake frequency.	0.1	0.2	0.5	-0.4	-0.7	-0.5	-0.0	-0.3	-0.5	-0.3
Number of full sisters	0.1	0.1	0.4	0.6	-0.0	-0.3	0.0	-0.1	-0.3	-0.2
Knee pain experienced in last month	0.1	0.2	0.5	-0.7	-0.0	-0.3	0.6	0.6	0.2	0.0
Back pain experienced in last month	0.1	0.1	0.3	-0.0	0.2	-0.0	0.5	-0.2	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.9	-1.4	-0.2	-0.4	0.2	-0.1	-0.0	-0.2
Leg fat percentage (left)	0.1	0.3	1.6	-1.3	-0.2	0.6	-0.3	-0.2	-0.1	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.4	-1.2	-0.6	-0.6	0.5	0.0	0.7	0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.8	-0.9	0.1	0.2	0.1	0.4	-0.2	0.1
Pack years of smoking	0.1	0.2	0.8	-0.1	-0.2	0.2	0.9	0.2	0.6	0.4
Impedance of whole body	0.1	0.7	1.3	1.1	-1.2	-1.0	-0.4	-0.9	0.3	-0.7
Leg fat mass (left)	0.1	0.6	1.8	-0.8	0.8	1.3	0.5	0.7	-0.0	0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Heel T-Score	0.0	0.2	0.5	0.2	0.3	0.6	-0.0	0.7	0.5	0.6
Height	0.0	0.3	0.8	0.9	0.5	0.2	0.6	0.4	0.4	0.2
Forced vital capacity (FVC)	0.0	0.2	0.8	0.2	0.9	0.6	0.1	0.1	0.1	-0.2
Exposure to tobacco smoke outside home	0.0	0.1	0.1	-0.4	-0.1	0.1	-0.4	-0.2	-0.3	0.0
Medication: Blood pressure	0.0	0.1	0.3	0.2	0.1	-0.3	0.0	-0.2	0.2	-0.5

Hub : Genes

NCF4

Models

Trait associations