TWAS hub - NDRG4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.2320	0.0760	2.5e-03	0.004	NA	0.040	NA	0.011	1.8e-01	NA	4.1e-03	NA	8.1e-02
2	GTEx	Cells Transformed fibroblasts	0.0980	0.0410	4.1e-03	0.049	NA	0.067	NA	0.063	1.3e-04	NA	9.0e-06	NA	1.7e-05
3	GTEx	Heart Left Ventricle	0.1820	0.0490	1.1e-05	0.133	NA	0.122	NA	0.178	1.5e-07	NA	4.9e-07	NA	9.2e-10
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0414	0.0205	1.5e-03	0.009	0.013	0.006	NA	0.008	3.3e-02	1.2e-02	5.9e-02	NA	4.1e-02
5	TCGA	Brain Lower Grade Glioma	0.0888	0.0327	3.2e-07	0.022	0.058	0.049	NA	0.038	1.4e-03	3.8e-07	2.6e-06	NA	3.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3	4	5
Frequency of tiredness / lethargy in last 2 weeks	5.5	9.0	17.8	0.6	4.1	3.2	4.2
Pulse wave Arterial Stiffness index	4.5	5.3	8.4	2.8	2.2	2.9	2.3
Hair/balding pattern: Pattern 2	4.2	5.4	13.8	3.7	1.1	3.2	1.3
Medication: Paracetamol	4.2	6.5	14.2	1.4	3.1	3.8	2.6
Bipolar Disorder (2011)	3.8	3.6	6.6	1.9	2.0	2.0	2.6
Pulse wave peak to peak time	3.8	4.4	7.3	-2.7	-2.0	-2.7	-1.9
Number of self-reported non-cancer illnesses	3.8	6.6	13.1	1.0	3.6	3.2	3.0
Bipolar Disorder or Schizophrenia	3.6	8.7	17.9	3.2	1.3	4.2	3.7
Mean Putamen Volume	3.6	4.1	7.2	2.0	2.7	2.6	1.7
Ulcerative Colitis	3.4	5.0	12.5	2.1	2.0	2.1	3.5
Bipolar Disorder (2018)	3.1	5.0	8.4	2.7	1.2	2.9	2.8
Ulcerative Colitis (UC)	3.1	5.8	12.1	2.4	2.5	2.2	3.5
Impedance of arm (right)	3.1	14.3	22.4	-4.1	-4.7	-4.7	-3.2
Arm fat-free mass (right)	3.1	15.9	29.4	2.6	5.4	5.2	4.0
Miserableness	3.1	5.3	11.8	0.3	2.8	3.4	2.6
Arm predicted mass (right)	3.0	15.2	29.5	2.5	5.4	4.9	4.0
Impedance of whole body	3.0	15.2	25.0	-4.2	-4.9	-5.0	-3.1
Whole body fat-free mass	2.9	16.4	31.2	2.5	5.6	5.3	4.1
Trunk fat-free mass	2.8	16.3	28.5	2.8	5.2	5.3	4.3
Trunk predicted mass	2.8	16.0	28.5	2.7	5.1	5.3	4.2
Whole body water mass	2.8	15.7	29.2	2.5	5.4	5.2	4.0
Headache pain in last month	2.7	4.6	10.4	1.0	3.2	2.8	2.0
Health satisfaction	2.7	3.6	10.1	1.1	2.4	3.2	0.8
Number of full sisters	2.7	3.3	8.0	0.8	2.7	0.7	2.8
Basal metabolic rate	2.7	15.2	30.7	2.1	5.5	5.1	3.9
Pulse rate, automated reading	2.6	8.4	17.7	-0.9	-3.4	-3.4	-4.2
Arm fat-free mass (left)	2.6	13.0	24.4	2.1	4.9	4.8	3.6
Schizophrenia (2014)	2.5	5.5	11.1	2.5	0.8	3.3	3.1
Impedance of arm (left)	2.5	11.4	19.5	-3.7	-4.2	-4.4	-2.5
Illness, injury, bereavement, stress in last 2 years	2.5	3.0	7.8	0.8	-2.8	-0.6	-2.5
Leg fat-free mass (right)	2.5	13.2	28.8	2.0	5.4	4.7	3.3
Leg predicted mass (right)	2.5	13.2	28.8	2.0	5.4	4.8	3.2
Arm predicted mass (left)	2.5	12.6	24.4	1.9	4.9	4.7	3.6
Taking other prescription medications	2.4	3.7	12.0	0.2	3.5	1.7	1.9
Leg fat-free mass (left)	2.3	12.4	27.8	1.6	5.3	4.6	3.2
Leg predicted mass (left)	2.3	12.0	27.7	1.6	5.3	4.5	3.1
Number of incorrect matches in round	2.3	3.8	9.2	-3.0	-0.5	-2.4	-1.9
Noisy workplace	2.3	2.9	4.1	2.0	1.8	2.0	1.7
Long-standing illness, disability or infirmity	2.3	3.6	11.3	0.7	3.4	1.8	1.7
Weight	2.2	11.0	26.9	0.8	5.2	3.9	3.5
Pulse rate	2.1	3.5	7.3	-0.8	-2.4	-2.0	-2.7
Medication: Paracetamol	2.1	3.5	8.6	0.9	2.4	2.9	1.5
Number of operations (self-reported)	2.1	3.1	9.3	-2.2	3.1	-0.7	0.7
Hand grip strength (left)	2.0	5.2	14.1	2.9	1.7	3.8	0.9
Severe depression (siblings)	2.0	2.3	5.3	2.0	0.5	2.3	1.3
Impedance of leg (right)	2.0	9.5	18.7	-3.1	-4.3	-3.9	-2.1
Schizophrenia (2018)	1.9	4.0	9.5	1.9	0.7	3.1	2.5
HbA1C	1.9	2.1	8.8	-0.6	3.0	0.2	1.2
Type 2 Diabetes (T2D) (2018)	1.9	3.6	8.4	0.6	2.9	2.6	1.5
Impedance of leg (left)	1.9	9.0	17.6	-3.1	-4.2	-3.7	-2.1
Had other major operations	1.9	2.3	10.1	-1.0	3.2	0.5	0.6
Leg fat mass (right)	1.9	7.5	21.2	0.0	4.6	3.0	2.7
Age at last live birth	1.9	2.8	8.1	1.8	-2.8	0.8	-1.4
Age started oral contraceptive pill	1.9	2.3	4.2	0.5	-1.9	-2.0	-1.9
Depression (Nagel 2018)	1.8	2.7	5.9	1.4	0.8	2.2	2.4
Diabetes (mother)	1.8	2.2	6.2	-2.5	2.0	-0.5	0.9
Hip circumference	1.8	7.9	16.6	1.3	4.1	3.4	3.1
Overall health rating	1.8	4.0	13.8	-0.2	3.7	1.8	1.6
Loneliness, isolation	1.8	2.4	5.9	-0.3	2.4	1.8	1.7
Irritable Bowel Disease (IBD)	1.7	4.1	8.2	2.3	1.4	2.2	2.9
Number of treatments/medications taken	1.7	3.0	7.6	-0.0	2.8	2.2	1.6
Body mass index (BMI)	1.7	7.3	21.5	0.9	4.6	3.0	2.3
Mouth/teeth dental problems	1.7	2.6	7.6	2.8	-1.2	2.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	1.7	2.0	4.6	-0.0	2.1	0.9	2.1
Emphysema/chronic bronchitis	1.7	1.9	5.9	0.8	2.4	0.4	1.7
Pain experienced in last month	1.7	2.8	12.4	0.2	-3.5	-1.2	-0.1
Leg fat mass (left)	1.7	6.8	19.7	0.0	4.4	2.9	2.4
Neuroticism (2016)	1.6	2.3	5.3	-1.0	2.3	0.8	2.1
Tinnitus: Yes, now most or all of the time	1.6	1.9	5.8	1.9	-0.2	2.4	0.3
Basal cell carcinoma (self-reported)	1.6	1.9	3.9	0.9	1.4	1.7	2.0
BMI	1.5	8.5	23.4	1.7	4.8	3.4	2.2
Age when periods started (menarche)	1.5	3.6	7.7	-2.6	-1.2	-2.8	-1.4
Supplements: Glucosamine	1.5	2.0	8.6	-2.9	-0.2	-1.0	-0.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.0	1.0	1.7	1.7	1.4
Medication: Simvastatin	1.5	2.2	5.6	0.2	2.0	1.1	2.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	2.0	4.9	-0.7	2.1	2.2	0.5
Arm fat mass (right)	1.5	6.4	19.0	-0.1	4.4	2.7	2.3
Whole body fat mass	1.5	6.2	19.4	-0.4	4.4	2.4	2.4
Had major operations	1.5	1.7	5.2	-1.6	2.3	-0.8	0.4
Arm fat mass (left)	1.5	6.1	18.1	0.1	4.2	2.7	2.3
Blood Platelet Count	1.4	15.7	23.9	-4.4	-3.8	-4.9	-4.5
Frequency of depressed mood in last 2 weeks	1.4	1.9	5.2	0.3	1.5	1.5	2.3
Fed-up feelings	1.4	2.5	6.3	-1.3	2.5	1.2	1.8
High blood pressure (mother)	1.4	1.9	4.8	0.8	2.2	1.8	0.8
Happiness	1.4	1.8	4.5	0.3	1.7	2.1	1.1
Pulse wave reflection index	1.4	1.8	4.1	1.9	0.7	2.0	0.9
Comparative height size at age 10	1.4	7.4	13.6	1.6	2.9	3.7	3.5
Qualifications: nursing, teaching	1.4	2.2	7.7	1.5	-2.8	-1.1	-0.5
Back pain experienced in last month	1.4	2.1	8.2	0.6	2.9	0.9	1.0
Depressed Affect (Nagel 2018)	1.3	2.8	6.6	-0.7	2.6	1.7	2.0
Diabetes (father)	1.3	1.6	2.9	1.5	1.4	0.9	1.7
Trunk fat mass	1.3	5.5	17.1	-1.2	4.1	1.9	2.3
Heart attack	1.3	1.6	3.6	0.9	1.9	0.8	1.8
Alcohol intake versus 10 years previously	1.3	1.9	4.9	0.9	2.2	1.8	0.7
Falls in the last year	1.3	1.7	4.5	0.8	2.1	1.2	1.5
Qualifications: A levels/AS levels or equivalent	1.3	2.8	4.8	-1.2	-2.2	-2.1	-1.8
Age at first live birth	1.3	2.4	9.0	1.2	-3.0	0.8	-0.9
Medication for pain relief, constipation, heartburn	1.3	2.3	8.3	0.5	-2.9	-1.5	-0.6
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.2	1.1	1.1	1.8	1.5
Mood swings	1.3	2.4	5.6	-0.8	2.4	1.2	2.1
Schizophrenia vs Biploar Disorder	1.2	1.6	5.4	1.5	0.3	2.3	0.7
Body Mass Index (BMI) (2010)	1.2	1.6	5.9	2.4	0.9	0.9	0.7
Blood Red Count	1.2	11.9	22.1	4.7	2.5	4.4	3.5
Waist circumference	1.2	4.4	14.1	0.4	3.8	1.9	2.0
Medication: Ibuprofen	1.2	1.4	3.7	-0.1	1.6	1.9	1.0
Average weekly champagne plus white wine intake	1.2	1.7	2.7	-1.6	-1.6	-1.4	-1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.9	1.0	1.5	1.7	1.2
Alzheimer’s Disease (in mother)	1.1	1.3	3.6	-0.5	-0.7	-1.9	-1.5
Verbal and Numeric Reasoning (VNR)	1.1	2.6	4.0	-2.0	-1.7	-1.6	-1.8
Angina	1.1	1.5	6.2	-0.2	2.5	-0.9	0.6
Supplements: Zinc	1.1	1.2	2.9	1.5	0.0	0.9	1.7
Average weekly fortified wine intake	1.1	1.3	3.7	-1.0	-1.1	-1.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	3.3	0.9	0.5	1.8	1.8
Illnesses of siblings	1.1	1.6	2.4	1.5	1.2	1.5	1.3
Father’s age at death	1.1	1.4	3.5	-0.6	-1.5	-0.9	-1.9
Medication for cholesterol	1.1	1.6	3.8	1.7	0.0	1.2	2.0
Osteoarthritis (self-reported)	1.1	1.5	4.1	1.2	-0.0	1.3	2.0
Medication: Gliclazide	1.1	1.3	5.0	0.1	2.2	1.0	0.7
Smoking status: Current	1.1	1.7	4.6	2.1	0.4	1.7	1.0
Hearing aid user	1.1	1.2	2.7	-1.2	-1.0	-1.6	-1.0
Medication: Atorvastatin	1.1	1.3	2.8	-1.2	1.7	-0.5	-1.4
Unable to work because of sickness or disability	1.1	1.4	3.6	-1.9	0.1	-1.1	1.5
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	2.5	-0.9	1.1	-1.6	-1.5
Ever had hysterectomy (womb removed)	1.0	1.1	3.1	-1.8	1.5	-0.1	0.1
Systolic blood pressure, automated reading	1.0	2.8	5.3	1.9	1.2	2.3	2.0
Current tobacco smoking	1.0	1.6	3.4	1.8	0.3	1.6	1.4
Pain all over the body in last month	1.0	1.1	4.5	-2.1	1.0	0.0	-0.2
Diabetes (self-reported)	1.0	1.5	4.1	-2.0	1.4	-0.9	-0.7
Illnesses of mother	1.0	1.2	2.9	1.7	-1.1	1.4	0.1
Leg fat percentage (right)	1.0	3.5	10.8	-0.6	3.3	1.6	2.0
Angina (self-reported)	1.0	1.3	5.2	-0.3	2.3	-0.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.5	0.7	1.6	1.2	1.2
Diabetes diagnosed by doctor	1.0	1.7	4.6	-2.1	1.8	-0.5	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	2.5	0.2	1.3	1.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	5.4	-0.4	-2.3	-1.1	-1.9
Cholesterol lowering medication	1.0	1.5	4.2	-2.1	1.0	-0.9	-1.1
Breast Cancer	0.9	2.1	5.9	2.0	0.1	2.4	0.8
Age at First Birth	0.9	1.3	2.4	1.4	-1.4	1.6	0.2
Systolic Blood Pressure	0.9	4.3	13.2	2.3	0.8	3.6	1.5
Hypothyroidism (self reported)	0.9	2.0	3.7	1.4	1.6	1.9	1.2
Pack years adult smoking proportion	0.9	1.3	4.8	-0.3	2.2	1.1	0.6
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.5	-1.6	1.3	-1.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.5	-1.2	0.6	-0.4	1.9
Heart disease (mother)	0.9	1.1	4.2	-2.0	0.7	-0.9	0.1
Arm fat percentage (left)	0.9	3.6	12.4	-0.8	3.5	1.5	1.6
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	-0.4	-1.6	-1.0	-1.3
Leg fat percentage (left)	0.9	3.3	10.9	-0.7	3.3	1.5	1.7
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.7	0.6	1.6	0.4	1.6
Neuroticism (Nagel 2018)	0.8	1.9	3.5	-0.1	1.9	1.7	1.7
Allergy or Eczema	0.8	2.1	5.4	2.3	0.3	1.6	1.5
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	3.9	-0.3	2.0	0.5	0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	-0.8	1.5	-0.3	1.2
Medication: Metformin	0.8	1.1	3.4	0.1	1.5	1.8	0.4
Hand grip strength (right)	0.8	2.2	7.4	1.7	0.7	2.7	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	3.7	-0.4	1.9	0.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	1.6	1.0	0.8	1.3	1.2
Qualifications: None of the above	0.8	1.7	7.2	-0.9	2.7	0.3	0.5
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.2	1.3	-0.7	0.9	1.5
Arm fat percentage (right)	0.8	3.2	10.8	-1.1	3.3	1.4	1.5
Medication: Cholesterol lowering	0.8	1.3	4.1	-0.4	2.0	0.3	1.5
Blood clot in the leg (DVT)	0.8	1.0	2.0	0.7	1.2	1.4	1.1
Body fat percentage	0.8	3.3	10.6	-1.6	3.2	0.9	1.6
Migraine (self-reported)	0.8	1.0	2.8	1.3	0.5	1.7	0.7
Guilty feelings	0.8	1.1	4.4	0.2	1.0	2.1	0.5
Coronary Artery Disease (CAD)	0.7	0.9	2.5	-1.4	-0.3	-1.6	-0.1
Neuroticism	0.7	1.7	5.7	-0.9	2.4	1.0	1.1
Trunk fat percentage	0.7	3.0	8.6	-2.0	2.9	0.5	1.5
Maternal smoking around birth	0.7	1.0	2.7	0.1	1.6	1.1	1.1
Qualifications: CSEs or equivalent	0.7	1.0	2.7	1.5	0.2	1.6	0.1
Medication: Atenolol	0.7	0.9	1.8	-1.3	1.3	-1.0	-0.3
Financial difficulties in last 2 years	0.7	1.0	3.3	-0.4	1.8	0.6	1.0
Allergy	0.7	1.5	3.0	-0.8	-1.4	-1.4	-1.7
Medication: Ramipril	0.7	0.9	2.9	-1.7	0.8	-0.7	-0.7
Neuroticism score	0.7	1.4	3.5	-1.4	1.9	1.0	0.8
Hair/balding pattern: Pattern 3	0.7	1.0	2.8	-1.3	-0.7	-1.7	-0.4
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.8	1.9	-0.1	0.3	1.2
Gout (self-reported)	0.7	1.0	2.3	1.5	0.3	1.3	0.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.2	1.2	1.5	1.3	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.9	0.6	-1.7	0.9	-0.5
Wheeze or whistling in the chest in last year	0.7	1.3	4.6	0.4	2.1	0.8	1.1
Medication: Omeprazole	0.7	0.8	2.4	-0.4	0.8	-1.0	-1.5
Alcohol intake frequency.	0.7	1.7	6.1	-0.5	2.5	1.3	0.4
Chest pain or discomfort	0.7	1.0	3.2	0.2	1.8	0.1	1.4
Mother’s age at death	0.7	0.8	2.2	0.1	-1.5	-1.0	-0.9
Myopia	0.7	1.0	3.8	0.5	-2.0	0.4	-0.9
Serious illness, injury or assault to yourself	0.6	0.7	1.7	-0.5	1.3	-0.4	1.1
Hair/balding pattern: Pattern 4	0.6	1.5	4.3	-1.2	1.3	-0.1	2.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.3	-0.7	0.9	0.1	-1.5
Comparative body size at age 10	0.6	1.6	5.8	-0.4	2.4	1.1	1.0
Number of full brothers	0.6	0.8	1.9	-1.3	-0.3	-1.4	0.2
Qualifications: College or University degree	0.6	1.9	3.5	-0.7	-1.9	-1.7	-1.6
Family relationship satisfaction	0.6	0.7	2.9	-0.3	-0.5	0.5	-1.7
Illnesses of siblings: Diabetes	0.6	0.8	1.7	-1.3	0.8	0.4	-1.2
Smoking status: Previous	0.6	0.9	3.0	-1.7	0.9	-0.4	0.8
Ever taken oral contraceptive pill	0.6	0.6	2.7	-0.3	0.6	0.0	1.6
High cholesterol (Self-reported)	0.6	1.1	4.5	-0.7	2.1	0.8	-0.1
Risk taking	0.6	0.9	2.1	0.9	1.5	1.1	0.6
Pack years of smoking	0.6	0.8	3.3	-0.1	1.8	0.8	0.5
Fasting Glucose	0.5	0.5	2.0	0.7	1.4	-0.1	-0.5
HDL Cholesterol	0.5	0.9	2.0	1.4	0.7	1.1	0.9
Rheumatoid Arthritis	0.5	0.7	1.6	-1.3	0.4	-0.7	-1.1
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.5	-0.8	1.6	-0.1	-0.0
Relative age voice broke	0.5	0.8	2.7	-0.0	-1.6	-0.4	-1.0
Stomach or abdominal pain in last month	0.5	0.6	2.0	0.0	1.4	0.8	0.7
Sitting height	0.5	3.5	11.5	-0.1	1.5	1.9	3.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.7	-0.5	1.3	0.6	1.2
Length of working week for main job	0.5	0.5	1.3	-1.1	-0.5	-1.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.4	1.8	-0.6	0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-1.0	1.2	0.5	-0.2
Neck or shoulder pain in last month	0.5	0.8	2.0	-1.4	1.3	0.0	-0.5
Medication: Aspirin	0.5	0.7	1.7	1.2	-0.2	0.5	1.3
Medication: Blood pressure	0.5	1.0	1.9	-1.4	0.9	-1.0	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.6	1.3	-0.0	0.6	1.1
Medication: Lisinopril	0.5	0.6	1.6	-0.2	1.1	0.5	1.3
Illnesses of father: High blood pressure	0.5	0.6	2.3	-0.1	0.9	1.5	-0.0
Irritability	0.5	0.9	2.8	-1.7	0.1	-1.2	0.0
Heart disease (siblings)	0.5	0.6	2.0	-0.8	-0.3	-1.4	-0.4
Alcohol drinker status: Previous	0.5	0.6	2.4	-1.5	0.3	-0.5	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	3.3	-0.7	-1.8	-0.8	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	2.0	-0.7	0.4	-1.4	-0.8
Crohns Disease (2017)	0.4	0.8	1.5	1.1	-0.1	1.2	1.1
LDL Cholesterol	0.4	0.6	1.8	-0.1	1.4	-0.9	0.6
Height	0.4	6.8	17.1	1.3	1.9	3.4	4.1
Waist Hip Ratio (WHR)	0.4	1.8	3.9	-1.5	-0.6	-2.0	-1.6
Average weekly spirits intake	0.4	0.5	1.0	-0.7	1.0	-1.0	-0.1
Sensitivity / hurt feelings	0.4	0.6	1.8	-1.1	1.3	0.1	0.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	1.1	0.6	1.2	1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.3	-0.2	1.1	0.6	0.9
Had menopause	0.4	0.5	1.9	0.3	-0.5	-1.4	-0.5
Fluid intelligence score	0.4	0.8	1.8	-1.4	-0.8	-1.2	-0.2
Prospective memory result	0.4	0.5	1.5	0.1	0.5	0.7	1.2
Standing height	0.4	3.7	8.9	-0.4	1.9	2.4	3.0
Birth weight of first child	0.4	0.8	2.5	-0.5	1.6	0.7	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	0.3	-0.7	-0.1	-1.3
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.3	0.5	-0.1	0.9	1.2
Exposure to tobacco smoke outside home	0.4	0.5	1.0	-1.0	0.9	-0.6	-0.6
Worry too long after embarrassment	0.4	0.7	1.7	-0.5	1.3	0.8	1.0
Shortness of breath walking on level ground	0.4	0.4	1.0	-0.3	0.9	1.0	0.5
Leg pain on walking	0.4	0.5	1.9	-0.1	0.8	1.4	-0.2
Supplements: Vitamin C	0.4	0.5	1.3	0.5	-1.1	0.5	0.9
Ever had bowel cancer screening	0.4	0.4	1.3	-1.1	0.2	-0.8	-0.5
Commuting to job workplace: Walk	0.4	0.4	0.7	0.8	0.5	0.6	0.8
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	-1.2	0.5	-0.7	-1.1
Mineral and other dietary supplements	0.4	0.5	1.0	0.6	-1.0	-0.5	-1.0
Osteoporosis (self-reported)	0.4	0.6	1.8	0.4	0.2	0.9	-1.3
Financial situation satisfaction	0.4	0.4	1.1	0.6	1.0	0.6	-0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.9	0.8	0.5	0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.6	0.9	-1.1	-0.2
Ever depressed for a whole week	0.4	0.5	1.4	0.8	0.5	1.2	0.3
Commuting to job workplace: Cycle	0.4	0.5	1.7	-0.1	-0.0	-1.3	-0.8
Alzheimer’s Disease (in father)	0.3	0.4	1.0	-0.5	0.6	-1.0	0.4
Major Depression (MDD)	0.3	0.3	1.1	-0.6	1.1	0.1	0.4
Reaction Time	0.3	0.5	2.1	0.2	0.5	1.4	0.3
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.6	-0.6	0.5	-0.6	-0.8
Lung FVC	0.3	1.8	5.1	-0.4	-2.3	-1.3	-1.4
Chronotype (morning person)	0.3	0.8	1.8	0.1	1.3	1.2	-0.8
Relative age of first facial hair	0.3	0.6	1.2	1.0	-1.1	0.6	-0.8
Townsend deprivation index at recruitment	0.3	0.5	1.3	-0.1	1.1	0.5	0.9
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.5	-0.3	0.7	-0.7
Past tobacco smoking	0.3	0.6	1.2	0.9	-1.1	-0.1	-1.1
Hearing difficulty/problems with background noise	0.3	0.5	2.0	-0.3	1.4	0.5	0.4
Time employed in main current job	0.3	0.3	0.8	0.9	-0.4	0.9	0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	-1.1	-0.5	-1.0	0.4
Depression (self-reported)	0.3	0.4	1.3	0.3	0.7	1.2	0.3
Lung cancer (father)	0.3	0.3	0.9	-0.7	-0.4	-1.0	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.3	-1.5	-0.6	-0.4	-1.2
Exposure to tobacco smoke at home	0.3	0.4	1.1	-1.0	0.8	-0.3	0.4
Breastfed as a baby	0.3	0.4	1.1	1.0	-0.9	0.1	-0.3
Birth weight	0.3	0.6	1.6	-0.5	1.2	0.8	0.7
Number of children fathered	0.3	0.4	0.7	-0.8	0.3	0.9	-0.6
Medication: Blood pressure	0.3	0.5	1.8	-1.4	0.7	-0.5	0.3
Knee pain experienced in last month	0.3	0.4	1.6	-0.5	1.2	-0.2	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.5	0.1	1.2	-0.1	-0.7
Average weekly red wine intake	0.3	0.4	1.2	0.7	0.6	1.1	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.6	-0.8	0.7	-0.3	0.6
Wears glasses or contact lenses	0.3	0.4	0.9	-0.6	0.5	0.5	1.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.7	-0.3	0.8	-0.8	0.4
Alcohol drinker status: Never	0.3	0.4	1.0	-0.8	1.0	-0.4	0.5
Average weekly beer plus cider intake	0.3	0.4	1.1	1.1	-0.3	0.5	0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.9	0.8	-0.2	0.9	0.0
Diastolic blood pressure, automated reading	0.3	1.0	2.4	0.7	-1.6	0.8	-1.2
Crohns Disease (2012)	0.2	0.4	1.8	0.0	-1.3	0.2	0.3
Lupus	0.2	0.3	0.7	-0.3	0.9	0.3	0.8
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.1	0.8	0.6	0.4
Triglycerides	0.2	0.4	0.9	-0.5	1.0	-0.6	-0.5
Smoking Status	0.2	0.6	1.0	0.9	0.6	0.9	1.0
Respiratory disease	0.2	0.4	1.1	0.8	-0.0	1.0	0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.8	0.8	0.4	-0.5
Vitamin and mineral supplements	0.2	0.2	0.5	-0.4	0.6	-0.3	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	1.0	-0.5	0.6	0.6
Multivitamins +/- minerals	0.2	0.3	0.8	0.9	-0.5	0.7	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.0	-0.2	-1.4	-0.8	-0.2
Worrier / anxious feelings	0.2	0.3	1.0	-0.4	1.0	0.3	0.5
Forced expiratory volume in 1-second (FEV1)	0.2	0.5	1.5	-0.7	-1.2	0.5	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.1	0.7	1.0	0.5
Peak expiratory flow (PEF)	0.2	0.5	1.5	-1.2	-0.8	-0.4	-0.5
High blood pressure (siblings)	0.2	0.2	1.0	-0.2	-0.2	0.1	-1.0
Eye problems/disorders: None of the above	0.2	0.3	0.7	0.9	0.2	0.1	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	0.2	0.7	0.9	-0.2
Medication: Aspirin	0.2	0.3	1.2	0.4	0.2	0.1	1.1
Hypertension (Self-reported)	0.2	0.5	1.3	-1.0	1.2	-0.1	0.1
Illnesses of father: Heart disease	0.2	0.2	0.9	-0.1	0.9	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.7	0.0	0.8	0.8	0.8
Eye problems/disorders: Cataract	0.2	0.3	0.7	-0.6	-0.5	0.2	0.8
Asthma (self-reported)	0.2	0.4	0.8	-0.8	-0.0	-0.6	-0.9
Ever smoked	0.2	0.3	0.9	-0.6	0.4	0.0	1.0
Supplements: Calcium	0.2	0.2	0.9	0.2	-0.9	0.2	-0.2
Ovarian Cancer	0.1	0.2	0.7	-0.3	0.3	-0.8	0.2
Prostate Cancer	0.1	0.2	0.4	-0.4	-0.0	0.6	-0.7
Blood Eosinophil Count	0.1	1.0	2.5	-1.6	1.4	-0.7	-0.4
Blood White Count	0.1	1.1	4.0	0.1	-0.3	-1.1	-2.0
Cardiovascular Disease	0.1	0.2	0.5	-0.7	0.7	0.3	-0.2
Lung FEV1/FVC ratio	0.1	0.5	1.3	-1.0	-1.2	-0.4	-0.1
Medication for hormone replacement therapy	0.1	0.2	0.5	0.6	0.1	0.7	0.1
Medication: Co-codamol	0.1	0.1	0.4	-0.2	0.6	-0.4	-0.1
High blood pressure	0.1	0.3	1.1	-1.0	0.4	-0.4	-0.4
Alcohol usually taken with meals	0.1	0.2	0.8	-0.4	0.9	0.4	-0.2
Forced vital capacity (FVC)	0.1	0.2	0.6	-0.8	-0.0	0.6	0.1
Asthma	0.1	0.2	0.7	-0.9	0.3	-0.4	-0.5
Medication: Lansoprazole	0.1	0.1	0.3	-0.5	0.3	-0.3	0.0
Tense / ‘highly strung’	0.1	0.1	0.2	0.5	-0.4	0.2	0.1
Loud music exposure frequency	0.1	0.1	0.4	-0.1	0.7	-0.1	-0.4
Glaucoma (self-reported)	0.1	0.1	0.2	0.3	0.2	-0.5	0.3
Medication: Amlodipine	0.1	0.2	0.5	-0.3	-0.7	-0.5	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	1.7	-1.3	0.1	-0.1	-0.9
Medication: Allopurinol	0.1	0.1	0.4	0.1	0.2	0.6	0.4
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.5	0.5	-0.0	0.0
Mean time to correctly identify matches	0.1	0.1	0.4	0.1	0.3	0.7	-0.1
Suffer from ‘nerves’	0.1	0.2	0.8	-0.5	0.0	0.9	0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	-0.5	-0.2	0.4
Friendships satisfaction	0.1	0.1	0.2	0.2	-0.4	0.2	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.3	-0.5	-0.3	-0.3	-0.4
Medication: Bendroflumethiazide	0.1	0.1	0.3	0.1	0.5	0.3	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.8	0.5	-0.9	0.3	0.0
Worry (Nagel 2018)	0.0	0.1	0.3	-0.1	0.4	0.5	0.2
Heel T-Score	0.0	0.2	0.6	-0.1	-0.4	-0.8	-0.5
Hair Pigment	0.0	1.4	3.9	2.0	0.2	1.5	0.7
Tanning	0.0	0.3	0.7	-0.6	-0.3	-0.9	-0.4
Medication: Levothyroxine sodium	0.0	0.1	0.1	0.4	0.2	0.3	0.0
Nervous feelings	0.0	0.1	0.2	0.2	0.3	0.5	-0.2
Number of live births	0.0	0.1	0.1	-0.3	-0.4	-0.2	-0.1
Breast cancer (self-reported)	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1

Hub : Genes

NDRG4

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Trait associations