Hub : Genes

NDST1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Breast Mammary Tissue	0.2510	0.0810	3.9e-03	-0.002	NA	0.023	NA	0.016	4.5e-01	NA	2.4e-02	NA	5.1e-02
2	GTEx	Breast Mammary Tissue (Female)	0.2482	0.1212	6.0e-02	0.009	NA	0.028	NA	-0.008	1.7e-01	NA	5.1e-02	NA	6.7e-01
3	GTEx	Spleen	0.5230	0.1090	5.3e-04	0.146	NA	0.087	NA	0.100	1.4e-04	NA	3.1e-03	NA	1.5e-03
4	GTEx	Thyroid	0.1630	0.0470	7.7e-05	0.089	NA	0.023	NA	0.044	2.5e-07	NA	6.8e-03	NA	2.7e-04
5	GTEx	Whole Blood	0.1710	0.0450	1.1e-04	0.122	NA	0.127	NA	0.126	2.7e-11	NA	9.7e-12	NA	1.1e-11
6	METSIM	Adipose	0.0981	0.0321	4.6e-04	0.051	0.031	0.050	0.051	0.047	3.4e-08	1.5e-05	4.5e-08	3.3e-08	1.2e-07
7	NTR	Blood	0.0427	0.0140	2.5e-04	0.019	0.009	0.010	0.012	0.012	6.4e-07	4.2e-04	2.2e-04	5.7e-05	4.8e-05
8	ROSMAP	Brain Pre-frontal Cortex	0.0598	0.0228	3.9e-03	0.049	0.025	0.034	0.029	0.036	6.2e-07	3.2e-04	3.3e-05	1.0e-04	1.7e-05
9	YFS	Blood	0.3373	0.0312	0.0e+00	0.269	0.246	0.285	0.285	0.286	2.9e-88	1.2e-79	5.1e-94	2.6e-94	2.0e-94
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.0293	0.0171	5.1e-03	0.010	0.012	0.000	NA	-0.002	2.2e-02	1.6e-02	3.1e-01	NA	6.1e-01
11	TCGA	Brain Lower Grade Glioma	0.0723	0.0379	5.1e-05	0.033	0.050	0.037	NA	0.037	1.0e-04	2.3e-06	4.1e-05	NA	4.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.1	0.2	0.9	-0.1	0.9	-0.5	-0.7	0.2	0.2	0.6	-0.1	0.4	-0.2	-0.5
Bipolar Disorder or Schizophrenia	0.3	0.6	2.6	-0.8	0.1	0.5	0.1	0.5	0.5	1.1	1.6	0.9	0.7	0.6
Depressed Affect (Nagel 2018)	2.1	4.4	7.1	1.2	2.0	2.4	2.6	-2.7	-2.3	-2.3	0.4	-2.4	1.7	2.1
Depression (Nagel 2018)	0.3	0.5	1.4	-1.0	-0.8	0.1	0.6	-1.0	-0.5	-1.0	-0.0	-1.2	-0.4	-0.1
Intelligence (Savage-Jansen 2018)	0.6	1.7	4.9	-0.3	-1.2	0.6	1.4	1.9	1.4	0.7	-1.0	1.7	2.2	0.9
Neuroticism (Nagel 2018)	2.6	6.0	15.4	1.6	1.6	3.3	3.9	-2.3	-2.1	-2.9	1.1	-2.1	2.2	2.4
Schizophrenia (2018)	0.5	1.1	4.7	-1.0	-0.6	1.0	0.6	0.6	0.5	0.9	2.2	0.9	1.0	1.2
Schizophrenia vs Biploar Disorder	1.2	1.6	3.4	0.3	-1.3	1.1	1.8	1.4	1.3	0.6	1.2	1.7	1.4	0.7
Worry (Nagel 2018)	1.9	4.1	14.6	1.0	0.8	2.8	3.8	-1.3	-1.4	-2.4	1.5	-1.2	2.0	1.9
Alzheimer’s Disease (in mother)	0.4	0.5	1.9	-0.6	0.2	-0.9	-0.4	0.2	-0.5	-0.7	-1.0	-0.4	-1.4	-0.3
Alzheimer’s Disease (in father)	1.5	1.7	4.7	-0.5	-1.4	-2.2	-1.9	0.6	0.6	0.1	-1.7	0.1	-1.6	-1.2
Alzheimer’s Disease (including proxy)	0.7	1.0	3.3	-0.3	0.3	-1.7	-1.1	0.2	-0.2	-0.6	-1.5	-0.6	-1.8	-0.5
Crohns Disease (2017)	0.7	1.6	4.5	1.4	2.1	-0.3	-1.6	-0.9	-0.8	-1.1	-1.0	-1.1	-1.6	-1.0
Irritable Bowel Disease (IBD)	0.3	0.6	1.7	0.4	1.3	0.3	-0.5	0.7	-0.2	-1.2	-0.6	0.2	-1.2	-0.9
Ulcerative Colitis (UC)	0.4	0.7	2.6	-1.1	0.6	0.2	-0.1	1.6	0.2	-0.7	-0.0	1.1	-1.0	-0.8
Major Depression (MDD)	1.0	1.2	3.8	-0.3	0.6	-1.8	-1.1	-0.6	-1.0	-0.7	-2.0	-1.1	-1.1	-0.5
Reaction Time	1.5	2.9	10.4	-0.7	-0.2	-1.2	-3.2	-1.1	-0.8	-0.5	-1.5	-1.4	-2.9	-2.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.8	-0.5	-1.5	-0.1	1.0	0.8	0.2	-0.2	-0.9	0.5	1.7	1.1
Breast Cancer	0.5	1.1	2.7	-0.4	1.6	-0.6	0.4	1.5	1.5	1.3	1.0	1.4	0.4	0.1
Ovarian Cancer	1.0	1.4	3.0	0.6	1.7	0.1	0.7	1.7	1.4	1.7	0.7	1.7	0.6	-0.4
Prostate Cancer	3.0	4.2	11.1	0.7	0.4	3.0	2.7	-0.4	-1.3	-1.1	2.7	-0.2	3.3	2.8
Age at First Birth	2.2	3.2	7.7	1.0	-0.1	1.3	0.8	-2.7	-2.6	-2.8	-0.7	-2.7	0.7	1.4
Bipolar Disorder (2011)	0.3	0.3	1.3	-0.8	1.1	0.2	-0.5	-0.6	-0.6	-0.2	-0.1	-0.6	-0.0	-0.1
Body Mass Index (BMI) (2010)	0.5	0.7	2.8	0.1	-0.5	0.0	-0.3	-0.9	-1.7	-1.3	0.1	-1.2	-0.4	0.4
Coronary Artery Disease (CAD)	0.3	0.3	1.1	-0.7	0.2	0.2	0.2	0.1	0.2	-1.0	-1.1	0.3	-0.5	-0.5
Crohns Disease (2012)	0.4	0.7	2.1	0.5	0.8	0.4	-0.1	-1.4	-1.0	-1.3	-0.6	-1.0	0.2	0.7
Mean Putamen Volume	0.1	0.1	0.7	0.8	0.0	0.3	-0.0	-0.5	-0.2	0.2	-0.3	-0.6	-0.1	0.3
Fasting Glucose	0.2	0.3	1.4	-0.3	-0.9	-0.2	0.3	-0.3	0.3	-0.0	-0.5	-0.2	-0.6	-1.2
HbA1C	0.7	0.7	2.0	-0.3	-1.0	1.4	0.9	0.5	-0.3	-1.0	0.1	0.0	1.3	1.1
HDL Cholesterol	0.2	0.4	1.0	-0.6	0.2	0.4	0.4	0.9	1.0	0.7	0.3	1.0	0.5	-0.2
LDL Cholesterol	0.2	0.3	0.6	0.5	0.3	-0.5	-0.7	0.4	0.7	0.7	-0.8	0.3	0.1	0.2
Lupus	1.3	2.0	6.6	-0.2	2.6	-1.5	-1.6	-1.0	-1.1	-1.3	-1.1	-1.3	-1.4	-1.3
Neuroticism (2016)	1.0	1.4	4.5	0.6	1.0	0.9	2.1	1.0	1.0	0.3	0.1	0.9	2.1	1.0
Primary Biliary Cirrhosis	1.0	1.4	5.9	2.4	2.3	0.2	-0.2	-0.0	0.5	0.7	-1.4	0.5	-0.3	-0.7
Rheumatoid Arthritis	1.0	1.4	2.9	1.4	1.7	0.0	-0.9	-1.1	-1.5	-1.7	-0.9	-1.5	-0.8	-0.2
Schizophrenia (2014)	0.4	0.9	2.0	-0.2	-0.0	1.1	0.8	1.0	0.7	1.1	1.4	1.2	1.0	0.4
Triglycerides	0.4	0.6	3.8	1.9	0.4	-0.5	-0.2	0.4	0.1	0.3	-1.1	0.2	-0.5	-0.9
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.5	-1.2	-1.2	-1.2	-0.8	0.5	-0.0	-0.3	-0.7	0.1	-1.0	-0.8
Ulcerative Colitis	0.8	1.2	4.2	-0.0	0.6	0.4	1.5	1.9	1.4	0.2	-0.3	2.0	0.5	0.1
Blood Eosinophil Count	0.1	1.1	2.6	1.0	-0.7	0.5	0.8	-1.4	-1.6	-1.1	0.6	-1.5	-0.7	0.5
Blood Platelet Count	0.2	2.8	6.7	0.4	0.5	1.8	1.2	-2.3	-2.5	-2.5	0.5	-2.6	0.4	1.1
Blood Red Count	0.1	0.8	2.5	1.2	0.3	-1.0	-1.0	-0.7	-0.9	-1.6	-0.4	-1.0	-0.7	-0.2
Blood White Count	1.3	9.9	31.9	1.9	0.4	1.0	0.8	-5.7	-5.1	-3.3	1.4	-5.6	-1.1	0.9
Heel T-Score	0.6	4.5	10.0	3.2	1.0	0.4	0.7	-2.8	-2.7	-3.0	-0.4	-3.1	-1.7	-0.9
BMI	0.6	3.4	15.6	-1.4	0.0	0.9	1.9	-0.2	-0.3	0.4	3.0	0.1	2.5	4.0
Height	0.5	10.0	19.7	1.3	1.7	3.2	2.9	-3.0	-3.7	-2.8	4.4	-2.5	3.3	4.4
Waist Hip Ratio (WHR)	3.3	14.6	36.0	4.0	0.8	2.7	2.3	-6.0	-5.4	-5.2	0.5	-5.9	0.8	2.0
Systolic Blood Pressure	0.3	1.5	5.0	0.4	1.0	0.8	2.2	-1.2	-0.8	-0.6	1.0	-0.8	1.7	1.7
Smoking Status	1.2	2.9	11.0	-1.9	-0.6	2.3	2.2	-0.3	0.1	0.5	3.3	0.0	1.3	2.2
Allergy or Eczema	0.7	1.8	4.5	1.7	1.0	-0.4	-0.7	1.7	1.7	2.1	-0.7	1.5	-0.3	-1.2
Cardiovascular Disease	0.4	1.2	2.7	0.8	1.0	0.6	0.9	-1.6	-1.6	-1.3	0.9	-1.6	-0.2	0.7
Hypothyroidism (self reported)	1.2	2.6	12.3	-0.7	-0.7	-3.5	-2.0	1.1	1.3	1.4	-1.5	0.9	-1.4	-1.3
Respiratory disease	0.3	0.6	1.5	-0.8	-1.2	0.6	0.0	0.6	0.7	1.2	1.0	0.7	0.3	-0.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.3	0.7	1.2	-0.0	0.3	-0.3	-0.5	-0.5	-1.0	-0.7	-0.6	0.0
Lung FEV1/FVC ratio	0.2	1.0	4.6	0.4	0.9	-1.6	-2.1	-0.4	-0.4	0.3	-0.8	-0.6	-1.0	-0.0
Lung FVC	2.0	10.3	27.9	-0.8	0.5	-4.4	-3.9	2.6	2.3	2.6	-5.3	2.1	-3.3	-4.0
Neuroticism	2.3	5.6	12.4	2.2	1.1	2.9	3.5	-2.2	-2.2	-2.9	1.3	-2.1	2.1	2.6
Chronotype (morning person)	1.0	2.3	4.4	-1.4	-1.6	-1.9	-1.4	1.9	2.1	1.7	0.1	1.6	-0.6	-1.2
Hair Pigment	0.0	1.2	2.8	1.1	0.6	0.1	0.4	-1.5	-1.7	-1.0	-1.4	-1.6	0.0	0.9
Tanning	0.1	1.0	3.4	0.1	-1.2	-1.1	-0.8	0.9	1.0	0.5	-0.6	1.0	-0.9	-1.9
Hand grip strength (left)	0.3	0.7	1.9	-0.4	-0.9	-0.1	-0.9	-1.1	-1.4	-1.3	-0.1	-1.1	0.1	0.6
Number of treatments/medications taken	1.1	1.9	5.9	-1.7	-0.3	1.5	2.2	-0.2	-0.7	-0.6	2.4	-0.5	1.3	1.5
Average weekly spirits intake	0.7	0.9	2.5	0.3	-0.2	-0.6	0.7	-1.1	-1.3	-1.6	-1.0	-1.5	0.2	0.5
Sensitivity / hurt feelings	1.6	2.8	7.1	2.5	2.7	2.0	2.4	-0.3	-0.4	-0.8	1.0	-0.1	1.8	1.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.5	-0.3	-0.6	0.5	1.1	-1.3	-0.8	-1.6	-0.6	-1.4	0.0	0.5
Hearing difficulty/problems: Yes	0.6	0.9	2.2	1.3	1.0	0.2	1.4	0.5	0.7	0.7	-0.6	0.8	1.5	0.7
Relative age of first facial hair	0.4	0.9	6.1	-1.4	-2.5	-0.1	-0.7	0.0	0.1	0.3	-0.6	-0.2	0.0	-0.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	4.2	0.3	1.3	-1.7	-1.3	0.0	0.1	-0.2	-2.0	-0.3	-1.2	-1.5
Ever used hormone-replacement therapy (HRT)	2.0	2.5	7.8	-2.8	-0.8	1.4	1.3	2.2	1.1	0.7	1.2	1.8	1.7	1.1
Ever had hysterectomy (womb removed)	0.3	0.4	1.0	0.4	0.8	-0.3	-0.1	-0.5	-0.5	-0.8	1.0	-0.5	-0.4	0.6
Systolic blood pressure, automated reading	0.3	0.9	3.8	0.2	-0.1	0.2	1.9	-0.6	-0.2	-0.1	0.2	-0.1	1.6	1.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.7	-0.2	0.1	0.1	0.5	0.4	0.4	0.2	-0.8	0.2	0.6	0.6
Angina	0.7	0.9	2.3	-1.3	0.5	-1.5	-1.2	0.4	0.4	0.6	-1.1	0.2	-1.1	-1.0
Medication for hormone replacement therapy	0.3	0.3	1.5	-0.1	-0.5	0.8	0.8	-0.2	-0.2	-1.2	0.2	-0.4	0.2	0.3
Vitamin and mineral supplements	1.4	2.0	6.3	-0.2	2.5	-1.5	-0.6	1.5	2.0	1.7	0.0	1.5	-0.4	-0.9
Supplements: Zinc	2.6	2.9	8.2	-1.2	-2.0	-2.5	-2.9	-0.2	-0.2	-0.4	-1.8	-0.7	-2.1	-1.9
Medication: Co-codamol	0.5	0.5	1.4	0.0	0.4	0.1	0.1	1.1	1.0	0.9	1.0	1.2	0.6	0.2
Medication: Metformin	0.2	0.3	1.2	-0.1	1.1	-0.3	0.2	0.1	-0.0	0.9	-0.6	-0.2	-0.5	-0.3
Diabetes (father)	1.5	1.9	4.3	0.1	0.1	0.4	1.3	-2.1	-2.0	-1.8	0.9	-1.8	1.0	1.5
Diabetes (mother)	0.5	0.6	2.4	-1.6	-1.0	-0.8	-0.5	0.8	0.7	0.9	-0.0	0.4	-0.3	-0.1
Severe depression (siblings)	0.3	0.3	1.3	0.4	-1.1	0.0	-0.5	-0.6	-0.3	-0.0	-1.0	-0.5	-0.1	0.3
Pack years adult smoking proportion	3.0	4.6	10.7	-0.2	1.1	2.0	1.9	-2.7	-2.5	-3.3	2.2	-2.5	1.1	2.4
Impedance of leg (right)	1.4	6.5	19.2	1.3	-0.1	-1.9	-3.0	2.3	2.3	1.6	-3.9	1.9	-2.6	-4.4
Leg fat-free mass (left)	1.4	7.3	20.9	0.1	1.4	1.4	2.3	-3.3	-3.0	-1.9	3.8	-2.6	2.5	4.6
Trunk fat percentage	0.8	3.1	10.8	-0.5	-0.2	-1.4	0.2	2.0	2.8	3.3	1.0	2.6	0.9	0.6
Hand grip strength (right)	0.9	2.5	7.4	-0.5	-0.7	-0.3	-0.1	-2.4	-2.7	-2.7	0.5	-2.3	0.0	1.0
Townsend deprivation index at recruitment	1.3	1.9	4.2	-0.9	-1.6	-2.0	-0.6	1.6	1.4	1.4	-0.8	1.7	-1.0	-1.3
Current tobacco smoking	0.6	1.0	5.5	-0.9	-0.5	0.8	0.5	-1.1	-0.0	0.3	2.3	-0.5	0.2	1.2
Average weekly fortified wine intake	1.4	1.7	2.8	1.0	1.5	1.3	0.8	-1.4	-1.3	-1.7	-1.5	-1.4	0.8	1.2
Maternal smoking around birth	0.9	1.4	3.8	0.6	1.9	1.4	1.5	-0.5	-0.8	-0.8	1.6	-0.4	0.8	1.2
Fed-up feelings	3.0	5.4	11.1	1.6	1.7	2.4	3.1	-2.3	-2.0	-2.2	1.3	-1.8	2.8	3.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	1.0	0.3	-0.1	-0.0	0.1	-1.0	-0.3	-0.8	-0.1	-1.0	0.0	0.7
Relative age voice broke	0.6	0.9	2.1	-0.5	-1.4	-1.3	-0.4	1.1	0.8	1.3	-1.1	0.7	-0.4	-0.8
Taking other prescription medications	0.9	1.4	5.6	-2.4	-1.7	-1.1	0.0	1.2	0.8	0.9	0.6	1.1	1.0	0.4
Age when periods started (menarche)	0.3	0.8	2.4	0.7	1.6	0.3	-0.0	-1.1	-0.8	-1.5	0.1	-1.1	-0.7	0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.4	-0.1	0.8	0.2	0.6	-0.9	-1.0	-0.4	1.6	-0.9	-0.5	0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	3.4	1.9	0.3	1.2	1.4	-1.4	-0.5	-0.8	0.2	-1.3	0.5	0.6
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.7	0.4	-0.5	0.3	0.1	-1.0	-0.7	-0.6	-0.4	-1.0	0.8	1.3
Qualifications: CSEs or equivalent	1.0	1.3	3.2	-0.0	0.3	-0.1	-1.1	-1.6	-1.3	-1.8	-0.8	-1.8	-1.2	-0.7
Serious illness, injury or assault to yourself	0.5	0.6	5.2	-2.3	0.4	0.3	0.6	0.3	-0.3	-0.6	0.2	-0.1	0.1	0.4
High blood pressure	0.2	0.7	1.9	1.0	0.3	0.7	1.1	0.2	0.2	0.6	0.9	0.5	1.2	1.4
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	1.0	0.3	-0.5	-1.0	0.3	0.5	0.8	-0.5	0.1	-0.3	-0.5
Multivitamins +/- minerals	2.9	3.7	8.4	-0.2	-2.2	2.0	1.2	-2.2	-2.9	-2.6	0.4	-2.3	1.2	2.1
Stomach or abdominal pain in last month	0.3	0.4	1.2	1.1	0.2	0.2	0.9	-0.4	0.2	0.0	1.1	0.1	0.8	0.7
Supplements: Glucosamine	0.3	0.5	1.2	-0.0	0.7	0.9	0.9	1.1	0.4	0.2	-0.6	0.7	0.2	-0.7
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	9.5	-1.6	-3.1	-0.9	-0.8	-0.1	-0.2	0.3	-0.2	-0.1	-0.2	0.5
Medication: Atenolol	0.3	0.3	0.8	0.9	-0.9	-0.1	0.7	0.4	0.7	0.3	0.4	0.6	0.1	-0.3
Medication: Levothyroxine sodium	1.9	3.3	6.7	-2.6	-1.6	-2.2	-1.3	2.4	2.0	1.7	1.4	2.3	-0.3	-0.4
Sitting height	0.6	4.2	11.8	0.6	1.5	-1.3	-2.1	-3.4	-2.8	-2.0	-0.7	-3.1	-1.9	-0.0
Chronic bronchitis/emphysema (father)	1.2	1.4	5.6	1.3	0.3	0.8	1.2	0.1	-0.3	-0.6	2.4	0.4	1.8	1.3
High blood pressure (mother)	2.5	3.6	13.3	0.9	-0.3	1.9	2.9	-0.6	-0.8	-0.7	1.6	-0.3	3.6	3.0
Body mass index (BMI)	0.2	0.9	3.9	-0.4	-0.2	-0.8	0.8	-0.1	0.5	1.0	1.3	0.4	1.0	2.0
Impedance of leg (left)	1.6	7.6	21.9	1.1	-0.2	-1.9	-3.1	2.6	2.8	2.1	-3.9	2.4	-2.7	-4.7
Leg predicted mass (left)	1.4	7.3	20.2	0.1	1.5	1.4	2.3	-3.3	-3.0	-1.9	3.7	-2.7	2.4	4.5
Trunk fat mass	0.4	1.6	4.2	-0.4	0.4	-0.7	0.8	0.3	1.2	1.9	1.9	1.1	1.4	2.0
Waist circumference	0.6	2.1	5.4	1.2	0.5	0.2	1.4	-2.3	-1.5	-0.8	1.5	-1.6	1.1	2.3
Number of incorrect matches in round	0.6	1.0	2.6	-1.5	-1.6	-0.3	-1.2	0.4	0.7	0.5	-1.2	0.4	-1.0	-1.0
Past tobacco smoking	1.4	2.6	7.5	0.7	-0.6	-2.7	-2.4	1.0	1.3	1.1	-2.1	1.1	-1.3	-1.8
Alcohol usually taken with meals	0.4	0.7	2.0	0.2	0.5	0.1	-0.1	-1.1	-1.4	-1.1	0.1	-1.3	0.5	0.8
Nervous feelings	1.8	3.4	10.6	0.4	1.1	2.4	3.3	-0.8	-1.6	-2.6	1.8	-1.0	1.5	1.6
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	4.5	1.6	1.3	1.3	1.8	-2.1	-1.2	-1.7	0.0	-1.9	0.2	1.2
Hearing difficulty/problems with background noise	1.9	3.0	7.6	1.5	0.4	2.4	2.7	-0.8	-0.5	-0.8	1.1	-0.3	2.8	2.6
Hair/balding pattern: Pattern 2	0.4	0.6	1.7	1.3	-0.9	-0.8	-0.7	-0.3	-0.2	-0.7	-1.0	-0.1	-0.5	-0.8
Had menopause	0.4	0.6	3.2	-1.8	-0.9	0.1	0.2	0.1	-0.5	-0.6	0.9	-0.3	0.2	0.7
Had other major operations	0.7	0.9	7.5	-2.7	-0.1	-0.3	-0.4	-0.5	-0.8	-0.0	0.5	-0.8	-0.0	0.7
Forced vital capacity (FVC)	0.4	1.4	5.0	-0.2	1.0	-1.1	-1.4	-0.4	-1.1	-1.1	-2.2	-0.7	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.7	4.7	1.7	1.4	1.8	2.2	-0.4	0.4	0.3	1.7	0.0	1.4	1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	3.4	-1.8	0.4	0.2	-0.4	0.1	-0.3	-0.9	0.9	0.0	0.1	-0.0
Qualifications: None of the above	0.5	1.1	2.6	0.3	0.8	-0.9	-0.4	0.9	1.6	1.6	0.2	1.2	-1.2	-1.3
Financial difficulties in last 2 years	0.6	0.8	5.2	1.7	2.3	-0.3	0.7	-0.3	-0.0	-0.6	-0.1	0.2	-0.2	-0.2
Mouth/teeth dental problems	4.4	6.8	14.9	-2.9	-3.9	-3.0	-3.5	1.9	2.2	2.6	-1.4	1.7	-2.1	-2.2
Heart attack	0.2	0.2	0.6	-0.3	0.6	0.0	-0.5	0.3	0.5	0.4	-0.4	0.2	-0.8	-0.6
Allergy	0.4	1.0	2.8	-0.9	-0.8	0.6	1.3	-0.9	-1.1	-1.7	0.5	-0.7	0.7	0.9
Pain all over the body in last month	1.8	1.9	4.3	-2.1	-0.8	0.4	-0.0	-1.9	-1.7	-1.3	1.8	-1.8	-0.3	1.2
Diabetes (self-reported)	0.4	0.7	2.8	1.2	1.7	0.8	1.1	-0.1	-0.2	-0.0	-1.0	-0.3	-0.3	0.0
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	4.0	2.0	1.7	0.3	0.5	0.4	0.1	0.7	0.1	0.2	1.2	1.1
Medication: Ramipril	0.2	0.3	0.8	-0.4	0.5	-0.1	0.3	-0.7	-0.6	-0.3	-0.4	-0.9	0.2	0.8
Medication: Simvastatin	0.4	0.6	2.1	-0.5	-0.4	0.3	0.8	-1.1	-1.0	-0.7	0.5	-1.5	-0.4	0.3
Fluid intelligence score	0.5	1.0	3.6	-1.2	-1.3	0.2	1.0	0.9	-0.3	-0.5	-0.2	0.1	1.9	1.3
Illnesses of siblings	1.1	1.6	3.6	1.4	-0.1	0.1	-1.1	-1.7	-1.9	-1.8	-1.0	-1.8	-0.3	-0.4
Neuroticism score	2.0	4.1	8.7	2.2	1.8	2.3	2.9	-1.8	-1.7	-2.4	0.7	-1.6	1.8	2.2
Weight	0.6	2.8	11.3	-0.4	0.9	-0.0	1.2	-1.9	-1.4	-0.3	2.7	-1.2	1.6	3.4
Impedance of arm (right)	0.8	3.9	12.1	0.2	-0.4	-0.8	-1.3	2.8	2.3	1.9	-2.2	2.3	-1.4	-3.5
Arm fat percentage (right)	0.4	1.5	5.7	-0.4	-0.0	-1.3	0.3	1.3	1.9	2.4	0.6	1.7	0.3	0.5
Trunk fat-free mass	2.0	11.4	23.8	0.7	2.1	1.8	2.0	-4.9	-4.6	-3.5	3.5	-4.2	2.0	4.8
Hip circumference	0.3	1.4	3.9	-1.1	0.3	-0.8	0.5	0.4	0.9	1.7	2.0	1.1	1.0	1.9
Time employed in main current job	0.2	0.3	0.9	-0.6	-0.9	-0.7	-0.9	0.1	0.5	0.5	-0.4	0.1	-0.1	0.0
Alcohol intake versus 10 years previously	1.1	1.7	4.5	-1.2	-0.7	-2.1	-1.8	0.1	0.5	1.2	-1.0	0.1	-1.6	-1.9
Father’s age at death	1.4	1.8	4.7	0.8	-1.9	0.1	0.4	-2.2	-1.7	-1.8	-0.4	-2.1	-0.9	-0.0
Worrier / anxious feelings	1.7	3.3	10.8	1.6	1.5	3.1	3.3	-0.6	-0.9	-1.7	0.7	-0.7	1.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	3.5	-0.5	1.1	0.7	1.9	0.2	0.4	0.3	0.6	0.3	1.1	1.2
Falls in the last year	0.7	1.0	2.3	0.1	0.2	-0.3	1.5	0.8	1.4	0.8	0.4	1.5	1.2	1.0
Hair/balding pattern: Pattern 3	0.3	0.5	2.1	-1.5	-1.2	0.1	-0.1	0.4	0.6	0.1	0.9	0.4	0.5	0.6
Number of live births	1.0	1.4	5.7	-0.4	0.8	-0.9	-0.4	-0.2	-1.1	-1.6	0.1	-0.7	-2.4	-1.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	6.1	1.0	1.7	-1.3	-1.8	-0.6	-1.1	-0.8	-2.5	-0.8	-1.4	-1.0
Pulse rate	0.1	0.2	0.7	0.4	-0.6	0.2	0.2	-0.6	0.3	0.2	0.1	-0.1	0.8	0.7
Happiness	4.7	5.7	9.8	-0.7	-0.1	2.5	2.6	-2.9	-2.7	-3.1	2.2	-2.6	2.2	2.7
Noisy workplace	0.6	0.7	1.5	-0.1	0.8	-0.6	1.0	0.4	0.8	1.2	0.8	0.8	0.9	1.2
Qualifications: A levels/AS levels or equivalent	3.6	7.9	20.4	4.5	1.3	3.1	2.1	-2.2	-2.8	-3.2	-0.1	-1.9	3.5	3.3
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	7.2	1.0	1.5	0.7	0.9	2.4	2.2	2.5	0.5	2.7	1.5	0.2
Mouth/teeth dental problems: Dentures	3.9	6.6	13.2	0.7	2.1	3.6	3.4	-2.5	-2.6	-2.5	2.1	-2.4	2.1	2.9
Asthma	1.0	2.0	4.2	-1.5	-0.8	-0.5	-1.4	2.1	2.0	2.0	0.2	1.8	-0.5	-0.9
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	6.0	-0.0	1.6	0.8	0.6	-2.5	-2.4	-2.1	1.6	-2.1	0.5	1.2
Medication: Cholesterol lowering	0.5	0.7	2.9	-0.8	-0.9	0.9	1.7	-0.3	-0.3	-0.8	1.0	-0.6	0.4	0.8
Depression (self-reported)	0.2	0.2	1.1	-0.1	1.0	-0.1	0.5	0.0	0.3	-0.0	-0.2	0.1	1.0	0.5
Medication: Lansoprazole	0.7	0.8	1.9	0.0	-0.5	1.3	1.4	0.1	-0.4	-0.5	1.0	0.2	1.3	1.3
Prospective memory result	3.3	4.1	8.5	0.6	0.7	-2.9	-2.6	1.2	1.8	1.4	-2.5	0.9	-2.7	-2.8
Lung cancer (father)	0.1	0.2	1.3	0.3	-0.2	0.2	-0.1	-0.0	-0.3	-0.4	-1.1	-0.2	-0.3	-0.1
Illnesses of mother	2.8	3.5	10.0	-0.5	0.0	-2.8	-3.2	0.4	0.6	0.6	-1.4	0.0	-3.2	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	4.5	1.1	1.0	-1.1	-1.3	-0.3	-0.8	-0.3	-2.1	-0.5	-0.5	-0.5
Pulse wave Arterial Stiffness index	0.6	0.6	1.3	0.3	1.1	0.6	0.5	-1.1	-0.9	-0.9	-0.8	-1.1	-0.5	-0.2
Impedance of arm (left)	0.7	3.1	8.9	-0.3	-0.6	-0.6	-0.8	3.0	2.3	1.8	-0.8	2.5	-0.8	-2.8
Arm fat mass (right)	0.3	1.2	5.2	-0.2	0.4	-0.4	1.1	-0.4	0.3	1.0	1.7	0.3	1.4	2.3
Trunk predicted mass	2.0	11.5	23.7	0.6	2.2	1.8	2.0	-4.9	-4.6	-3.5	3.5	-4.2	1.9	4.8
Standing height	0.9	9.3	17.3	0.1	2.6	2.0	1.5	-4.0	-4.2	-3.0	3.9	-3.6	1.8	3.9
Length of working week for main job	0.2	0.2	1.1	0.4	1.0	-0.1	0.2	-0.2	0.2	0.2	-0.0	0.2	0.4	0.6
Exposure to tobacco smoke at home	1.2	1.4	4.2	0.0	-0.2	1.1	0.2	1.6	1.5	2.0	0.6	2.1	0.2	-0.7
Breastfed as a baby	1.0	1.2	3.6	-0.4	-0.8	0.5	1.8	-0.3	-0.8	-0.9	1.4	-0.4	1.9	1.4
Tense / ‘highly strung’	0.9	1.4	5.0	1.4	0.0	1.0	1.3	-1.3	-1.3	-2.2	-0.4	-1.6	-0.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	-0.6	0.5	0.4	1.0	0.1	-0.7	-1.1	-0.6	-0.3	0.6	0.3
Hair/balding pattern: Pattern 4	0.8	1.9	4.6	0.7	0.8	1.4	1.3	-2.1	-2.2	-1.3	0.2	-2.1	0.4	1.2
Birth weight of first child	0.4	0.7	2.2	-0.0	1.1	0.4	-1.5	-1.0	-0.8	0.5	-0.5	-1.0	-1.0	-0.5
Peak expiratory flow (PEF)	0.4	0.9	4.0	2.0	1.8	0.7	0.3	-0.4	-0.9	-0.5	-0.1	-0.2	0.3	0.6
Pulse wave reflection index	0.8	1.0	4.6	0.4	2.1	-0.2	-0.0	-0.5	-0.7	-1.1	-0.5	-0.9	-1.3	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.9	0.1	-0.9	0.5	0.5	-0.6	-0.4	-0.5	0.8	-0.4	0.3	0.8
Loud music exposure frequency	3.1	3.4	7.4	-0.0	-0.0	2.5	2.7	-2.0	-1.8	-1.4	2.0	-1.8	1.7	2.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.7	0.8	0.4	2.0	0.9	-0.1	-0.7	-0.9	-0.3	-0.2	2.4	2.1
Mouth/teeth dental problems: Bleeding gums	3.9	5.0	10.0	2.4	1.4	1.7	1.2	-3.2	-3.1	-3.1	-0.4	-3.1	0.7	1.7
Blood clot in the leg (DVT)	0.7	0.9	3.0	0.6	1.1	-0.9	-0.3	0.3	0.9	1.1	0.2	0.5	-1.7	-1.4
Medication: Paracetamol	0.6	1.1	2.8	0.0	-0.0	0.2	0.9	-1.6	-1.5	-1.6	0.2	-1.7	-0.1	0.8
Headache pain in last month	0.2	0.3	0.7	0.1	0.5	0.1	0.6	-0.9	-0.8	-0.8	0.3	-0.6	-0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.6	-0.2	-0.3	-1.4	-1.9	0.3	0.4	0.9	-1.8	0.6	-0.8	-1.4
Glaucoma (self-reported)	0.2	0.2	0.7	0.2	-0.9	-0.7	-0.3	0.5	0.2	0.8	-0.1	0.5	0.0	0.2
Gout (self-reported)	0.6	0.8	2.1	1.0	0.1	1.4	1.0	0.0	-0.1	-0.8	1.1	0.4	1.2	0.9
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	6.5	-0.8	-0.9	-2.6	-1.2	1.5	1.7	1.5	-0.4	1.5	-0.1	-0.2
Medication: Amlodipine	1.5	2.1	7.5	0.0	0.2	2.4	2.7	0.3	-0.2	0.0	2.0	0.2	2.0	1.5
Medication: Ventolin 100micrograms inhaler	0.9	1.1	3.8	-1.4	-0.9	-0.1	-1.6	0.2	0.5	0.6	-0.1	0.3	-1.5	-1.9
Birth weight	1.4	3.1	7.9	-1.8	-1.5	-1.1	-2.4	1.3	1.0	1.2	-2.8	0.8	-1.8	-2.5
Chronic bronchitis/emphysema (mother)	1.5	1.7	6.4	0.3	0.3	1.5	2.5	-0.9	-1.1	-0.9	1.4	-0.8	1.1	1.8
High blood pressure (siblings)	0.4	0.6	3.4	-1.8	0.4	-0.1	0.0	0.9	0.3	0.4	1.0	0.7	-0.8	-0.2
Forced vital capacity (FVC), Best measure	0.2	0.8	3.1	0.5	0.7	-0.9	-0.8	-0.5	-1.2	-0.9	-1.8	-0.7	-0.5	-0.5
Body fat percentage	0.6	2.5	9.3	-0.7	-0.4	-1.8	-0.2	1.7	2.5	3.0	0.3	2.3	0.2	0.1
Leg fat percentage (right)	0.7	2.5	6.7	-0.5	-0.9	-2.6	-1.3	1.2	2.1	2.3	-1.2	1.6	-1.1	-1.0
Arm fat-free mass (right)	1.4	7.4	18.5	0.9	1.8	1.2	1.8	-3.8	-3.2	-2.5	3.2	-3.0	1.9	4.3
Exposure to tobacco smoke outside home	1.6	2.1	5.3	0.4	-0.3	-0.6	-0.8	1.7	2.3	1.7	-0.7	1.9	-1.4	-2.1
Comparative body size at age 10	0.5	1.3	4.7	0.1	-0.8	-2.2	-1.5	1.0	1.2	1.7	-0.2	1.0	0.2	0.4
Number of full brothers	0.4	0.5	4.6	-0.2	2.1	-0.0	0.6	0.0	0.4	-0.2	0.3	0.1	0.0	-0.1
Worry too long after embarrassment	3.0	5.0	11.7	2.4	1.5	3.1	3.4	-1.0	-1.2	-1.7	1.7	-0.9	2.9	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	-1.0	0.2	0.1	-0.1	-0.8	-0.6	-0.8	-0.9	-1.0	0.2	0.5
Wheeze or whistling in the chest in last year	0.4	0.8	5.4	2.3	1.1	0.2	-0.2	-0.1	0.5	0.9	0.3	0.2	-0.7	-0.6
Number of children fathered	0.9	1.0	1.7	0.9	0.8	-1.3	-1.0	0.8	1.3	1.2	-1.3	0.9	-0.4	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.7	2.0	6.5	1.7	2.5	1.5	1.9	-0.0	-0.2	-0.3	-0.5	0.0	2.1	1.6
Age at first live birth	0.3	0.5	1.4	1.1	0.7	0.4	-0.6	-0.6	-0.8	-0.5	-1.2	-0.7	0.4	0.3
Pulse wave peak to peak time	0.5	0.5	1.5	-0.3	-1.0	-0.2	-0.2	0.8	0.5	0.8	1.2	0.9	0.7	0.7
Health satisfaction	0.3	0.4	1.3	-1.2	-0.3	0.1	0.5	0.7	0.2	0.3	1.0	0.6	0.7	0.8
Shortness of breath walking on level ground	0.3	0.4	1.0	-0.1	0.1	-1.0	-0.7	0.6	1.0	0.8	-0.3	0.8	0.1	-0.1
Qualifications: College or University degree	0.6	1.8	6.9	2.1	0.1	1.2	0.4	0.1	-0.7	-1.2	-0.5	-0.0	2.6	2.2
Eye problems/disorders: None of the above	1.3	1.5	4.5	-1.5	0.0	0.3	-0.5	1.3	2.0	2.1	0.1	1.5	-0.5	-1.1
Mouth/teeth dental problems: Loose teeth	1.8	2.1	5.4	1.8	0.4	1.2	1.2	-1.8	-1.7	-2.3	1.7	-1.3	0.5	0.6
Emphysema/chronic bronchitis	1.5	1.7	4.5	1.1	0.5	0.3	1.0	-2.0	-2.1	-1.9	0.5	-1.8	-0.3	0.2
Medication for pain relief, constipation, heartburn	2.2	3.8	7.7	-0.1	-1.5	-1.2	-1.6	2.5	2.8	2.7	-1.7	2.6	-0.8	-1.8
Neck or shoulder pain in last month	0.7	0.9	2.6	1.6	0.9	1.1	1.6	-0.7	-0.7	-0.8	0.8	-0.9	-0.1	-0.1
Medication: Blood pressure	0.6	1.0	2.7	1.3	0.8	1.3	1.7	0.2	-0.1	-0.1	1.4	0.1	0.9	1.2
Angina (self-reported)	0.6	0.8	2.9	-1.7	0.5	-1.2	-1.0	0.5	0.3	0.5	-0.8	0.3	-0.8	-0.8
Migraine (self-reported)	1.9	2.3	6.1	-2.3	-1.6	-1.0	-1.9	0.5	0.6	0.9	-1.8	0.1	-2.5	-1.6
Medication: Ibuprofen	2.1	2.5	6.3	-0.8	0.9	1.4	1.2	-1.5	-1.8	-2.0	2.5	-1.3	1.3	1.9
Medication: Allopurinol	0.8	1.1	2.4	1.3	0.7	1.5	1.5	0.1	-0.2	-0.6	1.5	0.4	1.2	1.1
Medication: Omeprazole	0.8	0.9	2.0	-1.4	1.2	0.7	0.5	-1.0	-1.4	-0.5	0.9	-1.3	0.1	0.4
Medication: Seretide 50 evohaler	1.1	1.3	3.1	-1.6	-1.2	-0.2	-1.7	-0.4	-1.3	-1.1	-0.5	-0.9	-1.4	-1.0
Mean time to correctly identify matches	1.0	1.9	8.1	-1.1	-0.4	-0.9	-2.9	-0.6	-0.3	0.2	-1.2	-0.9	-2.3	-1.7
Heart disease (mother)	0.4	0.5	1.6	-0.8	-0.2	0.5	0.4	0.8	1.1	0.9	0.1	1.3	0.7	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.7	0.4	-0.1	-1.0	-0.5	1.8	1.9	1.1	-1.8	1.7	-0.7	-1.4
Whole body fat mass	0.3	1.1	3.8	-0.5	0.3	-0.7	0.7	-0.1	0.7	1.5	1.5	0.6	1.2	1.9
Leg fat mass (right)	0.1	0.5	1.9	-0.3	-0.1	-1.1	0.2	-0.4	0.4	1.0	1.0	0.2	0.4	1.4
Arm predicted mass (right)	1.4	7.2	19.5	0.7	1.8	1.2	1.8	-3.6	-3.1	-2.2	3.3	-2.9	2.0	4.4
Pulse rate, automated reading	0.2	0.6	1.9	-0.6	-0.8	0.5	0.1	-1.4	-0.8	-1.0	0.3	-1.3	-0.2	0.2
Alcohol intake frequency.	2.6	6.2	16.2	-3.3	-0.5	-3.7	-3.5	0.9	0.4	0.6	-1.1	0.0	-4.0	-3.5
Comparative height size at age 10	1.2	6.5	13.8	-0.3	1.2	1.6	1.7	-3.2	-3.7	-2.9	3.5	-2.9	1.4	3.1
Number of full sisters	2.3	2.8	8.0	-0.7	0.8	-2.1	-2.5	0.4	-0.2	-0.6	-2.4	-0.5	-2.8	-2.0
Suffer from ‘nerves’	1.3	2.1	6.0	2.0	0.9	1.8	2.4	-1.7	-0.8	-1.6	0.3	-1.3	0.9	0.5
Overall health rating	0.1	0.3	1.3	-0.3	0.4	0.1	1.1	0.4	0.6	0.4	0.8	0.3	-0.5	-0.3
Chest pain or discomfort	0.2	0.2	1.0	0.5	0.8	-0.1	0.3	0.1	-0.2	-0.5	-1.0	-0.3	0.3	0.1
Had major operations	0.7	0.8	2.2	0.4	1.5	0.8	1.0	-0.0	0.3	0.2	0.4	-0.1	1.4	1.4
Age at last live birth	0.4	0.6	2.8	1.7	1.2	0.7	-0.3	-0.3	-0.7	-0.3	-0.6	-0.4	0.7	0.8
Family relationship satisfaction	0.5	0.6	2.4	-0.9	0.1	0.9	0.1	-0.8	-0.9	-1.5	-0.4	-1.1	-0.6	-0.4
Leg pain on walking	1.3	1.6	6.0	-1.1	-0.3	-0.9	-0.6	1.5	1.9	2.5	0.8	1.5	-0.6	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	4.6	0.7	2.1	0.4	1.5	-0.3	-0.1	-0.0	-0.1	-0.1	0.8	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.0	-0.1	-0.7	-1.6	-1.2	-0.2	-0.1	-0.9	-1.7	-0.2	-0.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.7	2.4	0.6	-1.6	0.5	-0.4	-1.2	-0.8	-0.4	-0.5	-1.2	0.2	0.4
Medication: Aspirin	0.2	0.3	0.9	-0.2	-0.1	0.0	0.1	-0.7	-0.7	-0.9	0.6	-1.0	0.2	0.6
Supplements: Vitamin C	1.3	1.5	6.8	-2.6	-1.7	0.3	0.4	-0.5	-1.1	-1.2	0.1	-0.9	0.9	1.4
Knee pain experienced in last month	1.7	2.7	9.4	-1.1	-1.0	1.4	3.1	-0.9	-1.2	-1.5	1.6	-1.0	2.0	2.0
Hypertension (Self-reported)	0.2	0.5	2.1	1.4	0.5	0.8	1.0	0.0	0.2	0.6	0.2	0.2	0.7	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.7	0.2	1.3	0.2	0.1	0.1	0.0	-0.1	0.9	0.3	0.4	0.2
Illnesses of father: Heart disease	0.3	0.4	1.3	0.5	-0.1	0.9	0.9	0.3	0.1	0.2	0.7	0.4	1.1	0.9
Illnesses of siblings: Diabetes	1.1	1.4	3.1	-0.4	1.0	-1.4	0.2	1.7	1.5	1.5	1.2	1.8	-0.4	-0.3
Smoking status: Previous	1.2	1.7	6.0	-0.1	0.4	2.3	2.5	-0.5	-1.1	-1.2	1.2	-0.7	1.0	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	6.5	2.5	1.9	0.1	0.6	-1.3	-0.7	-0.3	0.6	-0.8	0.7	1.1
Whole body fat-free mass	1.7	9.9	23.7	0.4	1.9	1.6	2.2	-4.3	-3.9	-2.8	3.8	-3.6	2.3	4.9
Leg fat-free mass (right)	1.5	7.9	22.2	0.0	1.6	1.6	2.5	-3.4	-3.0	-1.9	4.0	-2.6	2.6	4.7
Arm fat percentage (left)	0.4	1.7	5.2	-0.7	-0.3	-1.3	0.5	1.3	1.9	2.3	1.1	1.7	0.5	0.7
Average weekly red wine intake	1.0	1.5	4.1	1.0	1.8	0.8	1.1	-0.8	-0.4	0.4	0.8	-0.6	2.0	2.0
Handedness (chirality/laterality): Left-handed	2.1	2.5	7.2	-0.3	-0.1	-1.4	-0.6	2.2	2.7	2.5	-1.7	2.0	0.6	-0.1
Mood swings	2.1	3.9	8.9	1.6	2.9	1.2	1.6	-3.0	-2.0	-2.3	-0.2	-2.6	0.6	1.5
Loneliness, isolation	0.3	0.5	2.0	0.6	-0.2	-0.1	0.5	-1.0	-0.5	-0.6	-1.4	-0.9	-0.2	0.0
Long-standing illness, disability or infirmity	0.4	0.6	2.4	-1.0	0.1	-1.6	-0.8	0.2	0.7	0.8	-0.5	-0.0	-0.8	-0.6
Ever had bowel cancer screening	0.7	0.8	1.8	0.1	-0.7	-0.5	-0.9	1.3	0.9	0.5	-1.3	1.0	-0.8	-1.0
Diabetes diagnosed by doctor	0.4	0.6	2.8	0.5	1.0	-0.6	0.1	0.6	0.5	0.4	-1.7	0.1	-1.0	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	2.3	0.0	0.3	-1.2	-0.5	0.9	1.0	1.0	-1.5	1.1	-0.3	-0.3
Friendships satisfaction	0.9	1.1	2.7	0.9	1.4	0.7	0.2	-1.5	-1.4	-1.6	0.6	-1.3	-0.3	0.1
Qualifications: nursing, teaching	0.5	0.7	5.7	2.4	-0.0	0.5	-0.1	0.0	-0.3	-0.9	-0.8	0.1	0.7	0.0
Commuting to job workplace: Walk	0.4	0.5	2.0	0.8	0.9	0.1	1.4	-0.4	-0.8	-0.3	0.7	-0.3	0.3	0.5
Eye problems/disorders: Cataract	0.4	0.5	1.4	0.6	-0.2	-1.2	-0.5	-0.5	-1.1	-0.9	0.7	-0.6	-0.1	0.0
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	5.4	0.6	2.3	-0.1	1.2	2.3	1.6	0.9	0.4	2.1	0.9	-0.2
Medication for cholesterol	0.4	0.7	1.3	0.6	0.7	0.5	0.7	-1.2	-0.9	-0.7	0.9	-0.8	0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	6.0	0.9	2.4	-1.0	-1.1	-0.5	-0.8	-0.6	0.0	-1.0	-2.1	-0.9
Back pain experienced in last month	0.3	0.5	2.8	1.1	1.7	-0.4	0.4	0.1	-0.0	-0.5	-0.3	0.2	-0.1	0.5
Mineral and other dietary supplements	0.4	0.6	1.4	0.3	1.0	-1.1	-0.5	-0.8	-0.8	-1.2	0.5	-0.6	0.3	0.8
Breast cancer (self-reported)	0.5	0.6	1.8	0.4	-0.2	0.4	0.3	-1.0	-1.3	-1.0	-0.3	-1.2	-0.4	0.0
Asthma (self-reported)	0.8	1.5	3.3	-1.4	-0.5	-0.2	-1.3	1.8	1.7	1.8	0.6	1.6	-0.4	-0.8
Osteoporosis (self-reported)	1.4	1.7	3.9	-0.7	-0.5	1.4	1.1	-0.8	-1.3	-1.4	1.9	-0.8	1.7	2.0
Osteoarthritis (self-reported)	0.4	0.5	2.4	0.4	1.6	0.8	1.1	-0.2	-0.5	-0.1	0.9	-0.2	0.4	0.1
Medication: Aspirin	0.3	0.3	0.9	-0.0	0.5	0.1	0.3	-0.4	-0.6	-0.9	0.7	-0.8	0.5	0.8
Medication: Gliclazide	0.8	0.9	3.6	0.3	-0.5	0.4	1.9	0.9	0.3	0.1	-0.3	0.5	1.6	1.4
Illnesses of father: None of the above (group 1)	1.5	1.8	5.1	-2.3	-1.5	-1.3	-1.8	-0.4	-0.6	-0.6	-0.5	-0.8	-2.0	-1.4
Smoking status: Current	0.7	1.1	5.7	-0.9	-0.2	1.1	0.7	-0.8	0.1	0.5	2.4	-0.2	0.7	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	7.2	0.4	-1.0	-2.7	-2.0	0.9	0.6	1.1	-2.6	0.9	-1.0	-1.1
Whole body water mass	1.7	9.6	23.5	0.6	1.9	1.6	2.2	-4.2	-3.8	-2.7	3.8	-3.5	2.3	4.8
Leg predicted mass (right)	1.4	7.6	21.1	0.0	1.6	1.5	2.4	-3.3	-3.0	-1.9	3.9	-2.6	2.5	4.6
Arm fat mass (left)	0.3	1.3	5.2	-0.4	0.4	-0.3	1.2	-0.4	0.2	0.8	2.1	0.2	1.3	2.3
Number of self-reported non-cancer illnesses	0.6	1.0	3.1	0.7	0.1	0.3	1.0	-0.7	-0.9	-0.2	1.5	-0.8	1.4	1.8
Average weekly champagne plus white wine intake	0.4	0.6	1.5	0.4	-0.4	1.2	0.7	-0.3	-0.7	-1.2	-0.3	-0.4	0.8	1.0
Miserableness	1.6	2.8	10.1	1.2	3.2	1.9	1.7	-1.5	-1.4	-2.0	-0.1	-1.4	0.9	1.2
Guilty feelings	1.0	1.4	3.9	1.2	0.6	1.4	2.0	-0.9	-1.1	-1.5	0.8	-0.7	1.1	1.1
Wears glasses or contact lenses	0.8	0.9	1.9	-1.0	-1.4	0.9	1.1	-0.7	-0.8	-0.7	0.8	-0.9	0.9	1.0
Ever taken oral contraceptive pill	0.4	0.4	2.7	-0.8	-1.7	0.1	0.5	0.2	0.3	-0.3	-0.5	0.2	0.1	-0.5
Hearing aid user	0.3	0.4	2.0	0.5	1.4	-0.3	0.8	0.3	-0.3	0.1	0.0	-0.1	0.8	0.7
Mother’s age at death	0.7	0.8	2.1	0.3	-0.8	-1.1	-1.1	0.7	0.9	1.4	-1.5	0.5	-0.4	-0.3
Financial situation satisfaction	2.8	3.5	6.5	-0.0	-0.2	2.5	2.1	-2.3	-1.9	-2.4	2.0	-1.8	1.6	1.8
Tinnitus: Yes, now most or all of the time	2.2	2.6	10.0	-0.1	0.3	-0.4	-0.8	2.0	2.5	3.2	-0.3	2.5	1.0	-0.3
Commuting to job workplace: Public transport	0.8	1.0	3.7	0.2	1.0	1.7	1.9	-0.1	-0.6	-0.3	1.1	-0.0	0.6	1.0
Eye problems/disorders: Glaucoma	0.3	0.3	0.8	0.9	-0.5	-0.8	-0.1	-0.2	-0.8	-0.1	0.2	-0.2	0.3	0.8
Medication: Blood pressure	0.2	0.4	1.0	0.1	-0.6	0.7	0.7	0.3	0.4	1.0	-0.5	0.5	0.7	0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.1	3.1	-0.1	0.4	-0.1	1.6	0.0	0.2	0.2	1.7	0.3	1.8	1.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	2.1	-0.6	-1.5	1.3	0.6	-0.2	-0.5	0.4	0.5	-0.4	-0.2	-0.3
High cholesterol (Self-reported)	0.3	0.6	1.4	-0.7	-0.4	-0.1	0.7	-0.8	-1.1	-1.2	0.5	-1.2	-0.5	0.3
Medication: Bendroflumethiazide	1.0	1.5	4.1	0.2	-1.0	1.3	1.7	1.0	0.6	0.6	2.0	0.8	1.3	1.7
Medication: Paracetamol	0.5	0.7	1.4	0.1	-0.2	0.2	1.2	-1.1	-1.0	-1.0	0.8	-1.1	0.2	1.1
Medication: Lisinopril	0.8	1.0	3.1	1.0	0.9	0.0	-0.4	-1.7	-1.1	-0.6	-0.1	-1.6	-1.1	-0.3
Medication: Atorvastatin	0.2	0.2	1.1	-0.2	0.0	0.1	0.6	0.6	0.3	-0.2	-0.2	0.3	-1.1	-0.6
Illnesses of father: High blood pressure	0.9	1.1	4.9	2.2	1.5	0.6	1.2	0.5	0.9	0.8	-0.5	0.8	1.0	0.2
Alcohol drinker status: Never	0.2	0.2	0.8	-0.4	0.2	0.1	-0.3	0.5	0.3	0.9	-0.1	0.4	0.4	0.5
Ever smoked	0.8	1.5	3.4	-1.0	0.8	1.9	1.6	-0.7	-0.6	-0.3	1.8	-0.8	0.9	1.7
Basal metabolic rate	1.4	7.9	20.8	0.4	1.9	1.2	1.9	-3.9	-3.4	-2.2	3.5	-3.1	2.1	4.6
Leg fat percentage (left)	0.6	2.3	5.7	-0.8	-1.0	-2.3	-1.1	1.2	2.2	2.4	-0.9	1.7	-1.0	-0.8
Arm fat-free mass (left)	1.1	5.8	15.9	0.4	1.4	0.8	1.4	-3.5	-3.0	-2.1	2.7	-2.8	1.6	4.0
Number of operations (self-reported)	0.5	0.7	2.8	-1.1	1.7	-1.2	-0.7	-0.1	0.1	1.0	0.8	-0.5	-0.5	0.4
Average weekly beer plus cider intake	0.8	1.1	5.6	1.6	-0.0	-0.3	-0.1	-0.1	-0.0	-0.1	-2.4	-0.1	-1.4	-1.4
Irritability	0.1	0.2	0.5	0.4	-0.1	0.6	0.6	-0.6	-0.4	-0.6	-0.3	-0.7	0.2	0.6
Risk taking	0.7	1.0	8.0	1.3	2.8	-0.3	0.7	-0.6	-0.4	-0.3	-0.4	-0.6	0.1	0.2
Ever had prostate specific antigen (PSA) test	0.8	1.0	5.1	0.4	-2.3	-0.3	-0.5	-0.8	-1.0	-1.2	-0.5	-0.7	-0.7	-0.8
Fractured/broken bones in last 5 years	1.1	1.4	5.1	-1.7	0.3	0.9	0.9	0.2	-0.6	-0.5	2.3	-0.1	1.3	1.8
Age started oral contraceptive pill	1.0	1.3	4.2	-1.6	-1.5	2.1	1.6	0.5	-0.2	-0.5	-0.1	0.0	1.3	0.6
Diastolic blood pressure, automated reading	0.5	1.5	5.4	2.3	0.6	0.1	1.2	-1.7	-1.0	-1.2	-0.5	-1.0	0.8	1.3
Ever depressed for a whole week	0.2	0.3	1.0	-0.6	-0.4	-0.4	-0.3	-0.1	-0.7	-1.0	-0.4	-0.6	0.3	0.3
Unable to work because of sickness or disability	1.1	1.4	6.4	-0.8	-1.3	0.7	1.5	-0.2	0.4	-0.1	2.5	0.7	1.5	1.3
Commuting to job workplace: Cycle	1.0	1.3	5.9	-0.3	-1.5	-1.6	-2.4	-0.2	-0.4	0.1	-0.6	-0.4	-1.4	-0.8
Myopia	0.9	1.3	3.1	1.7	0.6	1.0	1.2	1.2	1.4	0.9	-1.1	1.4	0.9	-0.0
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.7	-0.9	-0.1	-0.1	-0.5	-0.1	-0.2	-0.8	-0.3	-0.3	-0.5	-0.8
Cholesterol lowering medication	0.7	1.1	4.3	-0.3	0.8	-1.5	-0.8	0.5	0.3	0.3	-0.8	0.1	-2.1	-1.6
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.1	-1.4	1.1	0.2	-0.0	-0.4	-0.9	-0.0	0.9	-0.7	-0.1	0.2
Pain experienced in last month	2.4	4.1	8.8	-0.6	-0.5	-0.8	-3.0	2.1	2.1	2.8	-2.8	1.9	-1.4	-2.3
Supplements: Calcium	0.8	0.9	1.8	-1.0	-1.0	1.4	0.4	1.1	0.6	0.9	1.0	1.0	0.8	0.7
Basal cell carcinoma (self-reported)	0.8	1.0	3.1	0.3	-0.2	-0.3	-1.3	-1.6	-1.4	-0.6	0.6	-1.8	-0.5	0.5
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.3	0.6	0.2	-0.2	0.7	0.7	0.8	0.0	0.6	-0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.6	0.5	1.2	-1.1	-0.5	0.4	0.9	1.1	-0.0	0.5	-1.9	-1.6
Heart disease (siblings)	1.0	1.2	3.6	0.4	1.3	0.1	0.5	1.4	1.9	1.4	-1.0	1.6	0.5	-0.2
Alcohol drinker status: Previous	2.4	2.7	10.3	-2.5	0.3	-1.7	-1.5	-0.1	-0.3	-0.1	-0.8	-0.6	-3.2	-2.6
Pack years of smoking	2.4	3.6	8.8	-1.1	0.6	1.8	1.7	-2.2	-2.1	-3.0	2.1	-2.0	0.9	2.0
Impedance of whole body	1.0	5.2	15.1	0.5	-0.5	-1.3	-2.1	2.9	2.7	2.0	-2.6	2.5	-1.8	-3.9
Leg fat mass (left)	0.1	0.6	2.0	-0.4	-0.2	-1.1	0.2	-0.5	0.4	1.0	1.1	0.1	0.4	1.4
Arm predicted mass (left)	1.3	6.5	17.5	0.4	1.7	1.1	1.6	-3.6	-3.0	-2.1	3.0	-2.9	1.8	4.2