Hub : Genes

NDUFS8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0560	0.0240	5.4e-03	0.047	0.019	0.029	0.025	0.035	2.0e-06	2.0e-03	1.6e-04	4.5e-04	3.4e-05
2	GTEx	Adipose Visceral Omentum	0.1400	0.0540	1.9e-03	0.056	NA	0.026	NA	0.069	6.8e-04	NA	1.6e-02	NA	1.8e-04
3	GTEx	Ovary	0.3140	0.1210	8.0e-03	-0.012	NA	0.006	NA	-0.009	9.3e-01	NA	2.3e-01	NA	6.2e-01
4	GTEx	Skin Sun Exposed Lower leg	0.1950	0.0550	3.3e-06	0.081	NA	0.090	NA	0.093	3.2e-07	NA	7.1e-08	NA	3.9e-08
5	METSIM	Adipose	0.0525	0.0218	7.4e-04	0.015	0.025	0.010	0.024	0.016	2.4e-03	1.0e-04	1.1e-02	1.2e-04	1.5e-03
6	YFS	Blood	0.1581	0.0276	0.0e+00	0.102	0.136	0.150	0.146	0.152	2.1e-31	4.8e-42	9.2e-47	1.5e-45	1.8e-47

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.2	-0.6	-0.6	-0.9	0.4	0.2	-1.1
Bipolar Disorder or Schizophrenia	0.6	1.4	3.8	0.8	-0.9	-2.0	1.2	0.9	-1.0
Depressed Affect (Nagel 2018)	0.2	0.5	1.0	1.0	-0.6	-0.9	0.4	-0.5	-0.3
Depression (Nagel 2018)	2.6	3.8	6.3	2.5	-1.9	-1.2	2.0	-1.9	-2.0
Intelligence (Savage-Jansen 2018)	0.7	2.1	3.2	1.0	-1.7	-0.7	1.5	-1.7	-1.8
Neuroticism (Nagel 2018)	0.1	0.3	1.6	1.3	-0.3	0.3	-0.3	-0.3	-0.3
Schizophrenia (2018)	0.7	1.5	3.1	1.6	-0.7	-1.8	1.2	1.2	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	1.1	0.1	-0.9	-0.1	-0.3	0.5
Worry (Nagel 2018)	0.2	0.4	2.0	1.4	0.0	0.4	-0.1	0.0	-0.5
Alzheimer’s Disease (in mother)	0.3	0.4	1.6	-1.3	0.6	0.0	-0.5	0.1	0.3
Alzheimer’s Disease (in father)	0.1	0.1	0.4	0.1	0.7	-0.1	-0.3	-0.2	0.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.2	-0.4	0.1
Crohns Disease (2017)	0.3	0.7	3.1	0.5	-0.6	1.7	0.7	-0.4	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	1.2	0.0	0.0	1.1	-0.1	0.6	0.5
Ulcerative Colitis (UC)	0.1	0.3	1.1	-0.1	0.2	-0.4	-0.4	1.1	0.2
Major Depression (MDD)	1.6	1.9	3.9	0.5	-1.3	-2.0	1.4	-0.8	-1.7
Reaction Time	0.5	0.9	3.9	0.9	0.0	0.6	-0.3	2.0	0.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.0	-1.0	-0.4	-0.6	0.2	-0.9	0.1
Breast Cancer	0.1	0.2	0.3	-0.5	0.5	0.6	-0.2	-0.0	-0.4
Ovarian Cancer	0.9	1.2	3.3	-0.7	1.4	1.8	-1.1	-0.1	-0.5
Prostate Cancer	0.6	0.9	1.4	0.4	-1.2	-1.1	1.1	0.8	1.0
Age at First Birth	0.4	0.6	1.5	-0.6	1.2	-0.3	-1.0	0.4	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.6	1.7	0.4	-0.6	1.0	0.3	-0.7	-1.3
Coronary Artery Disease (CAD)	3.8	4.5	10.8	3.3	-2.8	0.5	2.5	-0.2	-1.2
Crohns Disease (2012)	0.1	0.2	0.4	0.0	0.6	0.3	-0.5	0.4	0.6
Mean Putamen Volume	0.5	0.5	2.4	-0.6	-0.3	-1.5	0.2	-0.5	-0.3
Fasting Glucose	0.7	0.9	4.2	0.6	-0.6	0.0	0.5	-2.1	-0.3
HbA1C	0.6	0.6	1.3	0.7	-0.7	0.2	0.9	-0.8	-1.1
HDL Cholesterol	0.7	1.2	2.1	1.4	-0.9	-1.0	1.2	-0.2	-1.5
LDL Cholesterol	0.1	0.1	0.4	0.3	-0.0	-0.6	0.1	-0.1	0.2
Lupus	0.4	0.6	1.4	0.8	-0.4	-0.7	0.2	1.0	1.2
Neuroticism (2016)	0.3	0.4	1.7	-0.2	0.5	0.1	-0.4	0.3	1.3
Primary Biliary Cirrhosis	0.5	0.7	1.9	-0.3	0.5	-1.4	-0.6	0.8	1.0
Rheumatoid Arthritis	0.7	1.0	2.0	1.4	-1.1	-0.7	1.2	-0.3	-0.7
Schizophrenia (2014)	1.1	2.5	6.8	2.1	-1.1	-2.6	1.3	0.7	-0.6
Triglycerides	0.3	0.5	1.6	-0.5	0.1	0.7	-0.3	-1.3	-0.5
Type 2 Diabetes (T2D) (2012)	1.8	2.0	3.3	-1.8	1.6	0.5	-1.6	1.3	1.3
Ulcerative Colitis	0.8	1.2	4.4	0.2	0.4	-2.1	-0.6	1.4	0.7
Blood Eosinophil Count	0.1	0.7	2.0	1.4	0.0	-0.1	-0.5	-1.4	-0.1
Blood Platelet Count	0.1	1.4	4.1	2.0	-0.0	-1.9	-0.2	0.0	-0.6
Blood Red Count	0.3	3.1	6.7	1.9	-2.4	1.1	2.6	-0.1	1.0
Blood White Count	0.0	0.3	0.6	0.8	-0.4	0.5	0.4	0.8	0.2
Heel T-Score	1.8	14.2	62.7	3.5	-1.1	-1.2	0.8	-7.9	-2.7
BMI	0.8	4.6	12.3	2.7	-1.4	-1.6	1.3	-3.5	-1.3
Height	0.0	0.6	1.2	-0.9	0.5	-0.7	0.5	1.1	0.8
Waist Hip Ratio (WHR)	0.9	3.9	7.7	-2.3	1.8	-0.3	-2.0	2.8	1.7
Systolic Blood Pressure	0.7	3.7	6.2	-2.5	1.6	2.2	-1.8	2.2	0.7
Smoking Status	1.0	2.4	6.6	2.1	-1.2	-2.6	1.2	0.6	-0.6
Allergy or Eczema	0.5	1.2	1.9	1.0	-1.2	0.8	0.7	-1.4	-1.2
Cardiovascular Disease	0.6	1.9	3.3	-0.8	1.5	-1.8	-1.8	0.6	1.1
Hypothyroidism (self reported)	1.5	3.4	7.2	-1.9	1.6	0.8	-1.7	2.7	1.8
Respiratory disease	1.1	2.6	7.9	0.6	-1.7	-2.8	1.1	-1.0	-1.5
Type 2 Diabetes (T2D) (2018)	1.1	2.0	4.8	1.5	-1.2	-0.5	1.0	-1.5	-2.2
Lung FEV1/FVC ratio	0.1	0.4	1.2	-0.1	0.4	-0.6	-0.3	-1.1	0.6
Lung FVC	0.4	2.0	6.4	2.1	-0.2	2.5	0.5	-0.8	0.5
Neuroticism	0.4	0.9	3.0	1.1	-0.6	-1.7	0.4	-0.6	-0.5
Chronotype (morning person)	0.3	0.7	3.0	-1.7	0.1	0.5	-0.3	1.0	0.3
Hair Pigment	0.2	6.3	22.6	4.8	-1.2	-1.8	1.2	-3.0	-0.4
Tanning	0.1	1.7	4.8	-2.2	1.6	-0.0	-1.7	0.3	0.3
Hand grip strength (left)	0.5	1.2	3.5	-0.4	0.7	1.6	-0.9	-1.9	-0.3
Number of treatments/medications taken	1.3	2.4	4.8	-2.2	1.7	-0.6	-2.1	1.3	0.4
Average weekly spirits intake	1.2	1.4	3.5	1.0	-1.5	0.8	1.9	-0.2	-1.1
Sensitivity / hurt feelings	0.4	0.6	1.2	-0.4	0.8	1.1	-0.9	-0.5	0.8
Frequency of depressed mood in last 2 weeks	2.5	3.4	5.7	2.4	-1.9	-1.8	2.0	-1.3	-1.6
Hearing difficulty/problems: Yes	0.6	1.0	1.7	-1.2	1.1	-0.5	-1.0	0.5	1.3
Relative age of first facial hair	0.8	1.6	3.1	-1.5	1.7	-0.8	-1.8	-0.5	-0.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	3.3	-1.8	1.6	0.6	-1.7	1.4	1.8
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.6	-1.6	0.9	0.0	-0.9	0.8	1.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	0.3	-0.5	-0.6	0.5	1.2	1.3
Systolic blood pressure, automated reading	2.1	6.0	8.0	-2.8	2.4	2.6	-2.5	2.8	1.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.5	-0.9	0.4	-1.9	-0.6	0.6	-0.2
Angina	0.6	0.7	3.9	-0.6	-0.2	-2.0	0.0	-0.1	0.4
Medication for hormone replacement therapy	0.1	0.1	0.3	0.0	0.0	0.1	0.1	0.6	0.4
Vitamin and mineral supplements	0.4	0.6	1.4	0.7	-0.1	1.2	0.3	1.1	0.6
Supplements: Zinc	0.6	0.6	1.1	1.0	-0.6	0.6	0.6	-1.0	-0.8
Medication: Co-codamol	1.0	1.1	3.5	-0.1	0.9	-0.2	-0.7	1.3	1.9
Medication: Metformin	0.8	1.1	2.5	1.6	-0.9	-1.1	1.0	-0.8	-0.8
Diabetes (father)	1.3	1.6	2.8	0.6	1.3	1.7	-1.3	1.2	1.3
Diabetes (mother)	1.0	1.3	2.6	-0.9	-0.7	1.2	0.4	-1.6	-1.4
Severe depression (siblings)	3.1	3.5	6.4	-2.4	2.5	1.0	-2.5	0.8	0.9
Pack years adult smoking proportion	0.2	0.3	0.5	-0.4	-0.3	-0.7	0.2	0.7	0.7
Impedance of leg (right)	1.6	7.8	24.0	-3.7	1.7	0.3	-2.1	4.9	1.4
Leg fat-free mass (left)	1.5	7.7	22.1	3.1	-2.0	-0.7	2.5	-4.7	-1.8
Trunk fat percentage	0.1	0.4	1.1	-0.6	0.2	-0.8	-0.2	-0.0	-1.1
Hand grip strength (right)	0.4	1.0	4.0	-0.2	-0.4	1.0	0.1	-2.0	-0.9
Townsend deprivation index at recruitment	4.6	6.5	10.8	2.8	-3.0	-3.3	3.0	-0.7	-1.3
Current tobacco smoking	0.8	1.3	4.0	2.0	-0.4	-1.5	0.2	1.2	0.2
Average weekly fortified wine intake	0.7	0.9	4.3	0.1	-0.4	-0.2	0.7	2.1	0.4
Maternal smoking around birth	1.0	1.4	3.4	-1.4	0.9	-0.9	-1.1	0.2	1.8
Fed-up feelings	0.2	0.4	2.1	0.1	0.1	-1.4	-0.1	-0.5	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	6.0	1.2	-1.2	-2.4	1.1	-1.7	-1.3
Relative age voice broke	0.6	1.0	3.1	-0.6	0.0	-1.1	0.1	-1.8	-1.0
Taking other prescription medications	0.5	0.7	2.7	-0.0	0.3	-1.6	-0.5	0.9	0.7
Age when periods started (menarche)	0.4	1.0	1.7	1.1	-1.3	-0.3	1.2	-0.8	-1.1
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	3.2	-0.3	-0.3	-0.2	0.4	1.1	1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	14.1	2.9	-1.1	-1.6	1.1	-3.8	-1.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.1	-1.8	0.9	-0.2	-0.9	0.0	0.7
Qualifications: CSEs or equivalent	1.0	1.3	3.6	1.9	-1.0	0.6	1.3	-1.2	0.0
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.5	-0.5	0.1	0.2	-0.4	-0.0
High blood pressure	1.4	3.9	8.5	-2.4	2.5	0.2	-2.9	1.0	1.4
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.4	1.0	-1.1	0.6	0.7	-1.2	-0.3
Multivitamins +/- minerals	0.4	0.5	2.0	-0.3	0.0	-0.5	-0.1	-1.4	-0.6
Stomach or abdominal pain in last month	0.2	0.2	0.5	-0.7	-0.4	0.4	0.3	-0.6	0.3
Supplements: Glucosamine	0.4	0.5	1.9	0.8	-0.1	-0.6	0.0	-0.1	-1.4
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.9	0.6	-0.9	-0.5	0.1	0.8
Medication: Atenolol	0.7	0.8	1.7	-0.9	1.3	0.1	-1.2	0.7	0.7
Medication: Levothyroxine sodium	1.7	2.9	4.5	-2.1	1.7	-0.9	-1.9	2.0	1.4
Sitting height	0.2	1.3	5.5	0.6	-0.4	-0.6	0.9	-2.4	0.9
Chronic bronchitis/emphysema (father)	0.3	0.4	1.5	0.4	0.0	-0.6	-0.2	-1.2	-0.6
High blood pressure (mother)	0.7	1.0	2.6	1.0	-0.4	-1.0	0.5	-1.0	-1.6
Body mass index (BMI)	0.6	2.6	9.7	1.6	-0.7	-0.4	0.7	-3.1	-1.5
Impedance of leg (left)	1.7	8.2	28.4	-3.8	1.4	-0.2	-1.8	5.3	1.1
Leg predicted mass (left)	1.4	7.7	21.9	3.1	-2.0	-0.7	2.5	-4.7	-1.8
Trunk fat mass	0.2	0.9	1.9	0.4	-0.5	-1.0	0.7	-1.2	-1.4
Waist circumference	0.1	0.5	1.1	0.4	-0.3	-0.8	0.4	-1.1	-0.8
Number of incorrect matches in round	0.6	1.1	2.2	1.2	-0.9	-0.7	1.0	1.5	-0.5
Past tobacco smoking	1.8	3.3	9.9	-1.9	1.5	3.1	-1.4	1.3	0.4
Alcohol usually taken with meals	1.2	2.0	4.0	-0.8	1.8	0.1	-1.5	1.3	2.0
Nervous feelings	0.1	0.3	0.7	0.3	0.1	0.4	-0.1	0.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.5	1.1	-1.3	-1.6	1.2	-0.4	-1.1
Hearing difficulty/problems with background noise	0.1	0.2	0.6	-0.2	-0.4	0.3	0.6	-0.8	0.3
Hair/balding pattern: Pattern 2	0.9	1.2	4.8	0.6	-0.8	0.9	0.7	-2.2	0.3
Had menopause	0.6	0.7	1.6	-0.8	0.5	1.3	-0.1	1.2	0.4
Had other major operations	0.3	0.4	1.2	0.5	-0.6	-1.1	0.5	0.2	0.7
Forced vital capacity (FVC)	0.2	0.9	2.7	1.0	-0.6	1.6	0.9	-0.4	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	7.9	2.5	-0.1	-0.7	0.3	-2.8	-1.0
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.7	-1.6	1.1	0.1	-1.2	-0.3	-0.4
Qualifications: None of the above	0.2	0.4	0.9	-0.9	0.4	0.0	-0.7	0.9	-0.1
Financial difficulties in last 2 years	2.8	3.8	9.5	0.4	-1.1	-3.1	0.7	-2.6	-2.1
Mouth/teeth dental problems	4.5	6.9	13.2	1.9	-2.7	0.0	2.5	-3.6	-3.3
Heart attack	0.4	0.5	1.0	-0.6	1.0	-0.2	-1.0	0.9	0.1
Allergy	2.1	4.9	7.8	-2.3	2.5	1.7	-2.0	2.8	1.8
Pain all over the body in last month	0.5	0.5	0.8	0.8	-0.9	-0.3	0.9	-0.1	-0.8
Diabetes (self-reported)	0.2	0.3	1.0	0.2	-0.2	-0.7	0.0	-0.5	-1.0
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.9	-1.2	0.4	1.7	-0.8	0.3	0.5
Medication: Ramipril	0.4	0.6	1.2	-0.6	0.5	0.0	-0.6	1.1	1.1
Medication: Simvastatin	0.2	0.3	1.3	-0.3	-0.1	-1.2	0.1	0.3	-0.1
Fluid intelligence score	0.2	0.4	1.3	0.2	-0.8	0.5	0.6	-1.1	-0.3
Illnesses of siblings	0.1	0.2	0.4	0.4	0.4	0.7	-0.4	-0.2	0.4
Neuroticism score	0.4	0.8	3.3	1.0	-0.4	-1.8	0.1	-0.4	0.2
Weight	0.7	3.6	9.1	2.0	-1.4	-1.0	1.7	-3.0	-1.5
Impedance of arm (right)	1.1	5.1	21.6	-2.3	1.2	0.3	-1.4	4.7	0.6
Arm fat percentage (right)	0.1	0.5	1.6	0.2	-0.0	-0.1	0.1	-1.1	-1.3
Trunk fat-free mass	1.2	6.6	17.8	2.8	-2.2	-0.5	2.8	-4.2	-1.2
Hip circumference	0.5	2.0	4.1	1.2	-1.1	-0.5	1.3	-2.0	-1.8
Time employed in main current job	0.2	0.2	0.8	-0.5	0.1	-0.3	0.2	0.9	0.6
Alcohol intake versus 10 years previously	0.1	0.1	0.3	0.3	-0.2	0.5	-0.0	0.1	-0.5
Father’s age at death	1.3	1.7	3.5	0.6	-1.6	-0.1	1.7	-0.7	-1.9
Worrier / anxious feelings	0.2	0.3	0.6	0.6	-0.5	0.4	0.3	0.8	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.4	1.5	-1.5	-1.0	1.3	-0.9	-0.9
Falls in the last year	1.3	1.7	5.4	-0.1	1.1	-2.3	-1.1	1.6	0.5
Hair/balding pattern: Pattern 3	0.5	0.8	1.6	0.2	-1.1	-1.0	1.3	0.5	-0.7
Number of live births	0.6	0.8	1.7	1.3	-0.6	1.3	0.6	0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.9	1.2	-0.2	2.2	0.6	-1.0	0.1
Pulse rate	0.2	0.3	0.6	-0.1	-0.5	-0.4	0.6	-0.8	-0.6
Happiness	0.9	1.1	4.0	-0.8	-0.7	0.6	0.8	-2.0	-0.6
Noisy workplace	1.0	1.2	2.4	-0.6	1.1	-1.3	-0.9	1.6	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	3.2	0.4	-0.2	1.8	-0.0	-0.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.2	-0.5	0.4	-1.8	-0.6	-0.2	0.8
Mouth/teeth dental problems: Dentures	0.9	1.6	3.1	-0.6	1.4	0.1	-1.4	1.8	1.5
Asthma	1.5	2.9	11.4	1.1	-1.5	-3.4	0.9	-0.8	-0.9
Medication: Ibuprofen (e.g. Nurofen)	3.1	4.0	8.8	-2.0	2.6	0.7	-3.0	1.2	1.4
Medication: Cholesterol lowering	0.1	0.2	0.8	-0.0	0.4	-0.1	-0.5	0.9	0.3
Depression (self-reported)	0.4	0.5	2.0	0.7	-0.3	-1.4	0.1	-0.5	-0.1
Medication: Lansoprazole	0.4	0.4	2.4	1.5	-0.0	-0.3	0.2	-0.3	0.0
Prospective memory result	1.6	2.0	2.7	-1.5	1.6	1.2	-1.6	1.4	0.9
Lung cancer (father)	0.3	0.4	0.8	-0.9	0.6	0.3	-0.6	-0.1	0.9
Illnesses of mother	0.6	0.7	2.5	0.6	0.3	-0.4	-0.2	1.1	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.1	1.4	-0.0	1.1	0.4	-1.8	-0.0
Pulse wave Arterial Stiffness index	0.3	0.4	1.5	-0.7	-0.3	0.3	0.1	0.5	1.2
Impedance of arm (left)	1.3	5.9	22.6	-2.7	1.4	-0.3	-1.6	4.8	0.8
Arm fat mass (right)	0.4	1.6	5.2	1.1	-0.7	-0.5	0.8	-2.3	-1.4
Trunk predicted mass	1.2	6.6	17.6	2.8	-2.1	-0.6	2.8	-4.2	-1.2
Standing height	0.2	1.6	4.7	0.8	-1.5	-1.2	2.2	-0.2	-0.3
Length of working week for main job	0.8	0.9	1.7	-1.3	0.9	-1.0	-1.2	-0.1	0.6
Exposure to tobacco smoke at home	2.3	2.5	3.5	1.8	-1.9	-0.9	1.8	-1.3	-1.7
Breastfed as a baby	0.4	0.4	1.6	0.2	0.3	-0.1	-0.2	0.9	1.3
Tense / ‘highly strung’	0.5	0.8	2.8	0.7	0.4	-1.7	-0.5	-0.9	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.1	3.2	6.8	1.9	-1.5	-2.6	1.1	-2.3	-0.7
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	0.5	-1.1	0.1	1.2	-1.3	-0.9
Birth weight of first child	0.8	1.4	4.2	-2.1	0.9	1.0	-0.6	0.7	1.3
Peak expiratory flow (PEF)	0.9	2.0	4.2	2.0	-0.7	1.6	0.9	-1.9	-0.6
Pulse wave reflection index	0.7	0.9	2.7	-0.8	0.5	0.7	-0.6	0.9	1.6
Ever highly irritable/argumentative for 2 days	0.5	0.5	1.0	-0.9	0.9	-1.0	-0.7	0.4	0.0
Loud music exposure frequency	0.8	0.9	3.4	0.6	-0.8	-1.9	0.8	-0.5	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.7	0.1	0.8	-0.3	-0.6	-0.3
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	4.8	-1.4	1.8	-0.8	-2.2	1.6	2.1
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.2	-0.4	-0.7	0.4	-0.5	-0.1
Medication: Paracetamol	0.1	0.2	0.5	-0.7	0.2	0.1	-0.4	0.3	-0.3
Headache pain in last month	1.2	2.1	6.0	-1.3	1.0	1.1	-0.9	1.4	2.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	2.1	1.5	-0.8	-0.5	1.1	-0.9	-0.7
Glaucoma (self-reported)	0.9	1.1	2.6	-0.8	1.1	-0.3	-0.8	1.1	1.6
Gout (self-reported)	1.3	1.8	4.6	-2.1	1.2	1.1	-1.2	1.2	0.6
Hypothyroidism/myxoedema (self-reported)	2.5	4.9	10.1	-2.6	1.8	1.0	-2.0	3.2	2.2
Medication: Amlodipine	2.8	3.9	6.1	-2.2	2.5	-0.3	-2.5	1.4	2.0
Medication: Ventolin 100micrograms inhaler	1.3	1.7	6.0	0.6	-1.0	-2.4	0.7	-1.3	-0.8
Birth weight	0.1	0.2	0.5	-0.1	-0.4	0.3	0.7	-0.5	0.1
Chronic bronchitis/emphysema (mother)	0.6	0.6	1.5	1.0	-1.2	-0.4	1.1	-0.3	-0.0
High blood pressure (siblings)	0.1	0.2	0.4	0.5	-0.6	-0.0	0.4	-0.6	-0.2
Forced vital capacity (FVC), Best measure	0.3	1.3	3.3	1.8	-0.9	0.5	1.2	-1.3	-0.3
Body fat percentage	0.1	0.5	1.8	-0.2	-0.1	-0.8	0.0	-0.5	-1.3
Leg fat percentage (right)	0.1	0.5	1.8	0.2	-0.3	-0.6	0.2	-0.7	-1.3
Arm fat-free mass (right)	1.1	5.7	17.6	2.1	-2.0	-1.2	2.4	-4.2	-1.2
Exposure to tobacco smoke outside home	0.3	0.4	1.8	0.4	-0.4	-0.1	0.3	-1.3	-0.7
Comparative body size at age 10	0.6	1.5	3.3	-1.2	1.8	0.8	-1.4	-1.1	0.7
Number of full brothers	0.6	0.8	1.6	1.3	-1.0	1.1	0.7	-0.0	-0.7
Worry too long after embarrassment	0.2	0.3	0.6	0.3	-0.5	-0.3	0.1	-0.8	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.6	0.1	0.1	-0.2	-0.4	-0.7	-0.0
Wheeze or whistling in the chest in last year	0.7	1.2	4.5	0.6	-1.3	-2.1	0.6	-0.3	-0.5
Number of children fathered	1.4	1.6	4.2	0.5	-0.9	2.0	0.9	-1.3	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	3.7	4.4	6.1	-2.4	2.4	-0.2	-2.5	1.7	2.4
Age at first live birth	0.1	0.2	0.4	0.7	-0.5	-0.3	0.5	0.4	0.4
Pulse wave peak to peak time	0.3	0.4	1.3	0.7	0.1	-0.3	0.1	-0.6	-1.1
Health satisfaction	0.4	0.6	1.7	0.1	-0.8	0.9	1.3	-0.2	-0.4
Shortness of breath walking on level ground	0.5	0.6	2.7	-0.5	-0.5	-1.6	0.6	0.5	-0.0
Qualifications: College or University degree	1.5	4.8	9.2	1.4	-2.5	-0.4	2.3	-3.0	-2.4
Eye problems/disorders: None of the above	0.8	0.9	2.0	1.4	-1.1	-0.2	1.2	-0.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.1	1.1	-0.3	-0.9	0.7	0.2	1.4
Emphysema/chronic bronchitis	5.9	6.7	9.9	3.1	-2.7	-1.2	2.3	-2.6	-3.2
Medication for pain relief, constipation, heartburn	1.4	2.4	4.4	2.1	-2.1	-0.8	2.1	-0.7	-0.8
Neck or shoulder pain in last month	0.5	0.7	3.6	0.4	-0.1	-1.9	0.1	0.0	0.8
Medication: Blood pressure	0.4	0.6	1.7	-1.3	0.7	0.7	-0.9	-0.6	-0.2
Angina (self-reported)	0.5	0.7	3.7	-0.5	-0.2	-1.9	0.1	0.1	0.4
Migraine (self-reported)	2.6	3.3	7.3	-1.2	2.6	0.3	-2.7	1.0	1.8
Medication: Ibuprofen	4.1	4.9	10.0	-2.4	3.0	0.4	-3.2	1.5	1.5
Medication: Allopurinol	2.5	3.3	5.8	-2.4	1.9	0.6	-1.8	2.2	1.4
Medication: Omeprazole	0.1	0.2	0.3	-0.5	0.0	0.4	0.0	0.6	0.5
Medication: Seretide 50 evohaler	1.4	1.6	3.1	-0.6	1.0	-1.8	-1.3	0.4	1.8
Mean time to correctly identify matches	1.2	2.3	10.8	-0.2	0.9	0.7	-0.9	3.3	0.9
Heart disease (mother)	0.2	0.3	1.4	-0.4	0.1	1.2	-0.0	0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	1.2	0.2	0.3	-0.3	-0.4	-1.1	-0.2
Whole body fat mass	0.3	1.4	2.9	0.8	-0.8	-1.0	0.9	-1.7	-1.6
Leg fat mass (right)	0.5	1.8	4.5	1.0	-0.9	-0.7	1.0	-2.1	-1.7
Arm predicted mass (right)	1.1	5.7	16.5	2.3	-1.9	-1.3	2.3	-4.1	-1.2
Pulse rate, automated reading	0.9	3.0	6.8	1.9	-1.4	-0.6	1.5	-2.6	-1.7
Alcohol intake frequency.	0.2	0.4	1.2	-0.4	0.5	1.1	-0.5	0.7	-0.3
Comparative height size at age 10	0.4	2.0	7.4	0.6	0.2	-1.2	0.2	2.7	1.6
Number of full sisters	0.2	0.3	0.8	0.8	-0.2	0.9	-0.1	0.2	-0.1
Suffer from ‘nerves’	0.3	0.5	2.7	1.6	-0.1	0.1	0.1	0.2	0.2
Overall health rating	0.3	0.5	0.9	1.0	-1.0	-0.2	0.8	-0.6	-0.6
Chest pain or discomfort	0.7	1.0	4.1	0.3	-1.1	-2.0	0.8	0.1	0.4
Had major operations	1.1	1.3	4.8	2.2	-0.7	-0.4	0.8	1.2	0.1
Age at last live birth	0.7	1.0	2.1	1.4	-0.9	1.2	0.9	0.6	0.6
Family relationship satisfaction	0.6	0.7	2.3	-1.5	0.6	0.3	-0.5	0.2	1.1
Leg pain on walking	0.6	0.8	2.0	0.7	-1.0	0.3	1.4	0.4	-1.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.6	0.1	0.7	-1.9	-0.5	1.6	0.5
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.3	-0.5	1.5	-1.5	-1.4	0.0	0.5
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	5.1	-0.4	0.5	2.3	-0.2	1.6	0.2
Medication: Aspirin	0.8	1.1	2.5	-1.6	1.4	0.6	-1.1	-0.2	0.6
Supplements: Vitamin C	0.6	0.7	2.1	0.4	-0.6	0.5	0.7	-0.9	-1.4
Knee pain experienced in last month	2.0	3.2	11.7	0.4	-0.9	-3.4	0.5	-2.1	-1.3
Hypertension (Self-reported)	1.2	3.3	6.8	-2.3	2.2	-0.3	-2.6	1.0	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	0.9	-0.1	-0.1	0.4	0.3	0.5
Illnesses of father: Heart disease	0.5	0.7	1.3	-0.9	0.7	-0.0	-0.8	1.1	0.8
Illnesses of siblings: Diabetes	0.9	1.2	2.8	0.7	-1.5	-0.8	1.7	-0.7	-0.6
Smoking status: Previous	0.5	0.7	2.6	0.2	-0.6	-1.6	0.6	-0.8	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	4.3	1.0	-1.0	-0.8	1.1	-2.1	-0.5
Whole body fat-free mass	1.3	7.2	20.9	2.9	-2.1	-0.6	2.7	-4.6	-1.5
Leg fat-free mass (right)	1.5	8.1	21.7	3.2	-2.2	-1.0	2.7	-4.7	-2.0
Arm fat percentage (left)	0.2	0.7	1.9	0.2	-0.1	-0.5	0.1	-1.3	-1.4
Average weekly red wine intake	0.4	0.6	1.1	-0.4	1.1	-0.0	-0.9	-0.9	0.8
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.1	0.9	0.3	0.9	-0.2	0.5	1.5
Mood swings	1.1	1.9	4.7	0.4	-1.1	-2.2	1.0	-1.6	-1.4
Loneliness, isolation	1.6	2.3	3.4	1.9	-1.5	-0.7	1.5	-1.3	-1.8
Long-standing illness, disability or infirmity	0.4	0.6	1.5	0.5	-1.2	-0.9	0.8	-0.1	-0.8
Ever had bowel cancer screening	0.7	0.8	3.9	-0.4	0.4	0.4	-0.1	2.0	0.7
Diabetes diagnosed by doctor	0.4	0.6	1.6	0.6	-0.5	-0.5	0.4	-1.0	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.0	0.2	0.4	-0.1	-0.4	1.0	0.9
Friendships satisfaction	0.6	0.7	1.4	-0.4	-0.9	-0.8	1.2	-1.2	0.4
Qualifications: nursing, teaching	0.5	0.8	2.2	0.3	-1.4	-0.2	1.5	0.6	0.3
Commuting to job workplace: Walk	0.7	0.8	3.7	0.0	-0.6	0.2	0.6	1.9	0.4
Eye problems/disorders: Cataract	1.8	2.1	3.7	-1.9	1.4	1.9	-1.4	0.2	1.2
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	6.6	-2.6	1.3	1.2	-0.8	2.2	2.3
Medication for cholesterol	1.5	2.3	3.5	1.3	-1.6	1.0	1.7	-1.9	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.9	-0.2	0.1	0.8	0.0	1.0	0.8
Back pain experienced in last month	0.1	0.2	0.6	-0.1	-0.4	-0.8	0.3	-0.3	-0.2
Mineral and other dietary supplements	0.9	1.2	3.0	-1.4	0.9	0.5	-0.9	0.7	1.7
Breast cancer (self-reported)	0.2	0.3	1.1	1.0	0.3	-0.4	-0.5	-0.1	0.2
Asthma (self-reported)	1.5	3.0	11.8	0.9	-1.7	-3.4	1.1	-0.7	-0.9
Osteoporosis (self-reported)	1.3	1.6	4.7	-1.6	0.9	0.8	-0.7	2.2	0.7
Osteoarthritis (self-reported)	0.4	0.5	1.1	-0.2	0.9	-0.3	-1.1	1.1	0.2
Medication: Aspirin	0.6	0.8	1.6	-1.2	1.3	0.4	-1.0	-0.4	0.5
Medication: Gliclazide	0.1	0.1	0.4	0.3	0.1	-0.6	-0.1	0.3	-0.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.7	1.3	-1.0	-1.0	1.0	-0.5	-0.5
Smoking status: Current	1.0	1.6	5.2	2.3	-0.7	-1.6	0.4	1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.6	6.1	-1.4	2.5	0.5	-2.1	-1.4	1.0
Whole body water mass	1.4	7.7	21.4	3.0	-2.2	-0.8	2.8	-4.6	-1.5
Leg predicted mass (right)	1.6	8.8	22.8	3.3	-2.3	-1.0	2.9	-4.8	-2.1
Arm fat mass (left)	0.4	1.7	5.6	1.1	-0.6	-0.6	0.8	-2.4	-1.4
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	-1.4	0.8	-0.4	-1.0	1.1	0.6
Average weekly champagne plus white wine intake	0.4	0.5	1.1	0.5	-0.9	-0.9	1.0	0.3	-0.3
Miserableness	0.2	0.4	0.9	0.8	-0.9	-0.1	0.8	-0.4	-0.3
Guilty feelings	0.4	0.6	2.4	0.1	0.0	-1.5	-0.1	-0.3	0.9
Wears glasses or contact lenses	0.2	0.3	0.9	-0.9	0.4	-0.5	-0.1	0.4	0.4
Ever taken oral contraceptive pill	2.0	2.2	4.8	1.4	-1.7	-0.5	1.5	-1.0	-2.2
Hearing aid user	0.5	0.6	3.0	-0.4	0.1	1.7	-0.1	0.4	-0.0
Mother’s age at death	0.4	0.5	0.8	0.9	-0.8	0.1	0.8	-0.3	-0.9
Financial situation satisfaction	0.8	0.9	2.3	-1.2	0.1	-1.5	-0.1	-1.0	-0.9
Tinnitus: Yes, now most or all of the time	2.6	3.1	6.8	2.2	-2.6	0.2	2.6	-0.1	-0.2
Commuting to job workplace: Public transport	0.3	0.3	0.6	0.2	-0.6	-0.7	0.7	0.2	-0.8
Eye problems/disorders: Glaucoma	0.4	0.5	1.4	-0.4	0.8	-0.3	-0.6	0.2	1.2
Medication: Blood pressure	1.3	2.5	4.6	-1.1	1.4	-1.0	-1.8	2.1	1.8
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.0	-0.7	0.4	0.3	-0.4	1.4	1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	2.6	0.6	-1.0	-0.2	1.2	-1.2	-1.6
High cholesterol (Self-reported)	0.9	1.5	5.9	0.1	1.1	-2.4	-0.7	0.2	1.2
Medication: Bendroflumethiazide	0.4	0.6	1.1	-0.6	0.9	0.5	-1.1	0.6	0.7
Medication: Paracetamol	0.3	0.5	1.7	-1.3	0.5	0.5	-0.6	0.5	-0.2
Medication: Lisinopril	0.2	0.3	0.9	-0.5	-0.5	1.0	0.4	0.0	-0.6
Medication: Atorvastatin	0.3	0.4	0.8	0.1	0.4	-0.9	-0.4	0.9	0.7
Illnesses of father: High blood pressure	0.4	0.5	1.4	-1.2	0.7	0.1	-0.8	0.5	0.4
Alcohol drinker status: Never	0.3	0.4	1.1	0.7	-0.2	0.6	0.4	-0.2	-1.1
Ever smoked	1.9	3.3	9.2	1.7	-1.4	-3.0	1.2	-1.9	-0.8
Basal metabolic rate	1.3	7.1	19.4	2.9	-2.1	-0.7	2.6	-4.4	-1.7
Leg fat percentage (left)	0.2	0.7	2.5	0.4	-0.6	-0.8	0.6	-0.6	-1.6
Arm fat-free mass (left)	1.1	5.5	16.1	2.5	-1.9	-0.9	2.4	-4.0	-1.1
Number of operations (self-reported)	1.3	1.9	5.0	1.0	0.5	-0.3	-0.7	2.1	2.2
Average weekly beer plus cider intake	1.4	2.0	3.2	1.3	-1.5	-1.8	1.3	-1.3	-1.1
Irritability	0.7	1.2	5.4	0.2	-0.8	-2.3	0.8	0.1	-0.4
Risk taking	1.1	1.6	3.5	1.9	-1.1	0.3	1.3	-1.4	-1.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	-0.4	0.4	0.1	-0.3	-0.5	-1.0
Fractured/broken bones in last 5 years	1.1	1.5	3.6	-1.3	-0.3	1.7	0.4	1.9	0.4
Age started oral contraceptive pill	1.0	1.3	2.7	-1.0	1.3	0.1	-1.2	1.6	1.0
Diastolic blood pressure, automated reading	0.9	2.7	6.2	-2.5	2.1	0.5	-2.3	0.2	0.3
Ever depressed for a whole week	0.6	0.7	1.2	0.7	-0.6	-1.1	0.6	-0.9	-1.0
Unable to work because of sickness or disability	0.8	1.0	3.0	-0.3	0.5	-1.7	-0.6	0.8	1.2
Commuting to job workplace: Cycle	1.1	1.3	3.1	1.6	-0.9	-0.1	0.8	-1.8	-0.9
Myopia	0.2	0.3	0.8	0.7	0.2	0.9	0.2	0.4	0.6
Vascular/heart problems diagnosed by doctor	1.7	4.7	9.8	2.4	-2.8	-0.2	3.1	-1.7	-1.4
Cholesterol lowering medication	0.5	0.7	3.3	-0.4	0.7	-1.8	-0.5	-0.1	0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.5	0.3	0.3	-0.2	0.4	0.1
Pain experienced in last month	1.0	1.7	9.4	-0.1	0.3	3.1	-0.0	0.7	-0.4
Supplements: Calcium	0.3	0.4	0.8	0.4	0.9	0.5	-0.8	0.6	0.2
Basal cell carcinoma (self-reported)	0.2	0.2	0.8	0.5	0.0	-0.5	0.0	-0.9	0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.7	-0.5	0.8	0.0	-0.8	0.7	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.1	-0.2	-0.3	0.2	-0.1	0.1
Heart disease (siblings)	3.4	4.2	6.7	-2.3	2.6	-1.1	-2.5	1.7	1.7
Alcohol drinker status: Previous	0.5	0.6	1.3	0.1	-1.0	-0.5	0.6	-0.7	-1.1
Pack years of smoking	0.3	0.4	1.0	-1.0	-0.1	-0.1	0.1	0.7	0.9
Impedance of whole body	1.6	8.2	28.9	-3.6	1.6	-0.3	-1.9	5.4	1.1
Leg fat mass (left)	0.5	2.1	4.3	1.1	-1.1	-0.9	1.3	-2.1	-1.8
Arm predicted mass (left)	1.1	5.8	16.5	2.7	-1.9	-0.8	2.4	-4.1	-1.2