Hub : Genes

NDUFS8

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0560 0.0240 5.4e-03 0.047 0.019 0.029 0.025 0.035 2.0e-06 2.0e-03 1.6e-04 4.5e-04 3.4e-05
2 GTEx Adipose Visceral Omentum 0.1400 0.0540 1.9e-03 0.056 NA 0.026 NA 0.069 6.8e-04 NA 1.6e-02 NA 1.8e-04
3 GTEx Ovary 0.3140 0.1210 8.0e-03 -0.012 NA 0.006 NA -0.009 9.3e-01 NA 2.3e-01 NA 6.2e-01
4 GTEx Skin Sun Exposed Lower leg 0.1950 0.0550 3.3e-06 0.081 NA 0.090 NA 0.093 3.2e-07 NA 7.1e-08 NA 3.9e-08
5 METSIM Adipose 0.0525 0.0218 7.4e-04 0.015 0.025 0.010 0.024 0.016 2.4e-03 1.0e-04 1.1e-02 1.2e-04 1.5e-03
6 YFS Blood 0.1581 0.0276 0.0e+00 0.102 0.136 0.150 0.146 0.152 2.1e-31 4.8e-42 9.2e-47 1.5e-45 1.8e-47

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 1.2 -0.6 -0.6 -0.9 0.4 0.2 -1.1
Bipolar Disorder or Schizophrenia 0.6 1.4 3.8 0.8 -0.9 -2.0 1.2 0.9 -1.0
Depressed Affect (Nagel 2018) 0.2 0.5 1.0 1.0 -0.6 -0.9 0.4 -0.5 -0.3
Depression (Nagel 2018) 2.6 3.8 6.3 2.5 -1.9 -1.2 2.0 -1.9 -2.0
Intelligence (Savage-Jansen 2018) 0.7 2.1 3.2 1.0 -1.7 -0.7 1.5 -1.7 -1.8
Neuroticism (Nagel 2018) 0.1 0.3 1.6 1.3 -0.3 0.3 -0.3 -0.3 -0.3
Schizophrenia (2018) 0.7 1.5 3.1 1.6 -0.7 -1.8 1.2 1.2 -0.4
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 1.1 0.1 -0.9 -0.1 -0.3 0.5
Worry (Nagel 2018) 0.2 0.4 2.0 1.4 0.0 0.4 -0.1 0.0 -0.5
Alzheimer’s Disease (in mother) 0.3 0.4 1.6 -1.3 0.6 0.0 -0.5 0.1 0.3
Alzheimer’s Disease (in father) 0.1 0.1 0.4 0.1 0.7 -0.1 -0.3 -0.2 0.2
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 -0.3 0.4 -0.2 -0.2 -0.4 0.1
Crohns Disease (2017) 0.3 0.7 3.1 0.5 -0.6 1.7 0.7 -0.4 -0.2
Irritable Bowel Disease (IBD) 0.1 0.3 1.2 0.0 0.0 1.1 -0.1 0.6 0.5
Ulcerative Colitis (UC) 0.1 0.3 1.1 -0.1 0.2 -0.4 -0.4 1.1 0.2
Major Depression (MDD) 1.6 1.9 3.9 0.5 -1.3 -2.0 1.4 -0.8 -1.7
Reaction Time 0.5 0.9 3.9 0.9 0.0 0.6 -0.3 2.0 0.3
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.0 -1.0 -0.4 -0.6 0.2 -0.9 0.1
Breast Cancer 0.1 0.2 0.3 -0.5 0.5 0.6 -0.2 -0.0 -0.4
Ovarian Cancer 0.9 1.2 3.3 -0.7 1.4 1.8 -1.1 -0.1 -0.5
Prostate Cancer 0.6 0.9 1.4 0.4 -1.2 -1.1 1.1 0.8 1.0
Age at First Birth 0.4 0.6 1.5 -0.6 1.2 -0.3 -1.0 0.4 0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.5 0.6 1.7 0.4 -0.6 1.0 0.3 -0.7 -1.3
Coronary Artery Disease (CAD) 3.8 4.5 10.8 3.3 -2.8 0.5 2.5 -0.2 -1.2
Crohns Disease (2012) 0.1 0.2 0.4 0.0 0.6 0.3 -0.5 0.4 0.6
Mean Putamen Volume 0.5 0.5 2.4 -0.6 -0.3 -1.5 0.2 -0.5 -0.3
Fasting Glucose 0.7 0.9 4.2 0.6 -0.6 0.0 0.5 -2.1 -0.3
HbA1C 0.6 0.6 1.3 0.7 -0.7 0.2 0.9 -0.8 -1.1
HDL Cholesterol 0.7 1.2 2.1 1.4 -0.9 -1.0 1.2 -0.2 -1.5
LDL Cholesterol 0.1 0.1 0.4 0.3 -0.0 -0.6 0.1 -0.1 0.2
Lupus 0.4 0.6 1.4 0.8 -0.4 -0.7 0.2 1.0 1.2
Neuroticism (2016) 0.3 0.4 1.7 -0.2 0.5 0.1 -0.4 0.3 1.3
Primary Biliary Cirrhosis 0.5 0.7 1.9 -0.3 0.5 -1.4 -0.6 0.8 1.0
Rheumatoid Arthritis 0.7 1.0 2.0 1.4 -1.1 -0.7 1.2 -0.3 -0.7
Schizophrenia (2014) 1.1 2.5 6.8 2.1 -1.1 -2.6 1.3 0.7 -0.6
Triglycerides 0.3 0.5 1.6 -0.5 0.1 0.7 -0.3 -1.3 -0.5
Type 2 Diabetes (T2D) (2012) 1.8 2.0 3.3 -1.8 1.6 0.5 -1.6 1.3 1.3
Ulcerative Colitis 0.8 1.2 4.4 0.2 0.4 -2.1 -0.6 1.4 0.7
Blood Eosinophil Count 0.1 0.7 2.0 1.4 0.0 -0.1 -0.5 -1.4 -0.1
Blood Platelet Count 0.1 1.4 4.1 2.0 -0.0 -1.9 -0.2 0.0 -0.6
Blood Red Count 0.3 3.1 6.7 1.9 -2.4 1.1 2.6 -0.1 1.0
Blood White Count 0.0 0.3 0.6 0.8 -0.4 0.5 0.4 0.8 0.2
Heel T-Score 1.8 14.2 62.7 3.5 -1.1 -1.2 0.8 -7.9 -2.7
BMI 0.8 4.6 12.3 2.7 -1.4 -1.6 1.3 -3.5 -1.3
Height 0.0 0.6 1.2 -0.9 0.5 -0.7 0.5 1.1 0.8
Waist Hip Ratio (WHR) 0.9 3.9 7.7 -2.3 1.8 -0.3 -2.0 2.8 1.7
Systolic Blood Pressure 0.7 3.7 6.2 -2.5 1.6 2.2 -1.8 2.2 0.7
Smoking Status 1.0 2.4 6.6 2.1 -1.2 -2.6 1.2 0.6 -0.6
Allergy or Eczema 0.5 1.2 1.9 1.0 -1.2 0.8 0.7 -1.4 -1.2
Cardiovascular Disease 0.6 1.9 3.3 -0.8 1.5 -1.8 -1.8 0.6 1.1
Hypothyroidism (self reported) 1.5 3.4 7.2 -1.9 1.6 0.8 -1.7 2.7 1.8
Respiratory disease 1.1 2.6 7.9 0.6 -1.7 -2.8 1.1 -1.0 -1.5
Type 2 Diabetes (T2D) (2018) 1.1 2.0 4.8 1.5 -1.2 -0.5 1.0 -1.5 -2.2
Lung FEV1/FVC ratio 0.1 0.4 1.2 -0.1 0.4 -0.6 -0.3 -1.1 0.6
Lung FVC 0.4 2.0 6.4 2.1 -0.2 2.5 0.5 -0.8 0.5
Neuroticism 0.4 0.9 3.0 1.1 -0.6 -1.7 0.4 -0.6 -0.5
Chronotype (morning person) 0.3 0.7 3.0 -1.7 0.1 0.5 -0.3 1.0 0.3
Hair Pigment 0.2 6.3 22.6 4.8 -1.2 -1.8 1.2 -3.0 -0.4
Tanning 0.1 1.7 4.8 -2.2 1.6 -0.0 -1.7 0.3 0.3
Hand grip strength (left) 0.5 1.2 3.5 -0.4 0.7 1.6 -0.9 -1.9 -0.3
Number of treatments/medications taken 1.3 2.4 4.8 -2.2 1.7 -0.6 -2.1 1.3 0.4
Average weekly spirits intake 1.2 1.4 3.5 1.0 -1.5 0.8 1.9 -0.2 -1.1
Sensitivity / hurt feelings 0.4 0.6 1.2 -0.4 0.8 1.1 -0.9 -0.5 0.8
Frequency of depressed mood in last 2 weeks 2.5 3.4 5.7 2.4 -1.9 -1.8 2.0 -1.3 -1.6
Hearing difficulty/problems: Yes 0.6 1.0 1.7 -1.2 1.1 -0.5 -1.0 0.5 1.3
Relative age of first facial hair 0.8 1.6 3.1 -1.5 1.7 -0.8 -1.8 -0.5 -0.5
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 3.3 -1.8 1.6 0.6 -1.7 1.4 1.8
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.6 -1.6 0.9 0.0 -0.9 0.8 1.3
Ever had hysterectomy (womb removed) 0.6 0.7 1.7 0.3 -0.5 -0.6 0.5 1.2 1.3
Systolic blood pressure, automated reading 2.1 6.0 8.0 -2.8 2.4 2.6 -2.5 2.8 1.2
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.5 -0.9 0.4 -1.9 -0.6 0.6 -0.2
Angina 0.6 0.7 3.9 -0.6 -0.2 -2.0 0.0 -0.1 0.4
Medication for hormone replacement therapy 0.1 0.1 0.3 0.0 0.0 0.1 0.1 0.6 0.4
Vitamin and mineral supplements 0.4 0.6 1.4 0.7 -0.1 1.2 0.3 1.1 0.6
Supplements: Zinc 0.6 0.6 1.1 1.0 -0.6 0.6 0.6 -1.0 -0.8
Medication: Co-codamol 1.0 1.1 3.5 -0.1 0.9 -0.2 -0.7 1.3 1.9
Medication: Metformin 0.8 1.1 2.5 1.6 -0.9 -1.1 1.0 -0.8 -0.8
Diabetes (father) 1.3 1.6 2.8 0.6 1.3 1.7 -1.3 1.2 1.3
Diabetes (mother) 1.0 1.3 2.6 -0.9 -0.7 1.2 0.4 -1.6 -1.4
Severe depression (siblings) 3.1 3.5 6.4 -2.4 2.5 1.0 -2.5 0.8 0.9
Pack years adult smoking proportion 0.2 0.3 0.5 -0.4 -0.3 -0.7 0.2 0.7 0.7
Impedance of leg (right) 1.6 7.8 24.0 -3.7 1.7 0.3 -2.1 4.9 1.4
Leg fat-free mass (left) 1.5 7.7 22.1 3.1 -2.0 -0.7 2.5 -4.7 -1.8
Trunk fat percentage 0.1 0.4 1.1 -0.6 0.2 -0.8 -0.2 -0.0 -1.1
Hand grip strength (right) 0.4 1.0 4.0 -0.2 -0.4 1.0 0.1 -2.0 -0.9
Townsend deprivation index at recruitment 4.6 6.5 10.8 2.8 -3.0 -3.3 3.0 -0.7 -1.3
Current tobacco smoking 0.8 1.3 4.0 2.0 -0.4 -1.5 0.2 1.2 0.2
Average weekly fortified wine intake 0.7 0.9 4.3 0.1 -0.4 -0.2 0.7 2.1 0.4
Maternal smoking around birth 1.0 1.4 3.4 -1.4 0.9 -0.9 -1.1 0.2 1.8
Fed-up feelings 0.2 0.4 2.1 0.1 0.1 -1.4 -0.1 -0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 6.0 1.2 -1.2 -2.4 1.1 -1.7 -1.3
Relative age voice broke 0.6 1.0 3.1 -0.6 0.0 -1.1 0.1 -1.8 -1.0
Taking other prescription medications 0.5 0.7 2.7 -0.0 0.3 -1.6 -0.5 0.9 0.7
Age when periods started (menarche) 0.4 1.0 1.7 1.1 -1.3 -0.3 1.2 -0.8 -1.1
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 3.2 -0.3 -0.3 -0.2 0.4 1.1 1.8
Heel bone mineral density (BMD) T-score, automated (left) 2.2 5.0 14.1 2.9 -1.1 -1.6 1.1 -3.8 -1.5
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 3.1 -1.8 0.9 -0.2 -0.9 0.0 0.7
Qualifications: CSEs or equivalent 1.0 1.3 3.6 1.9 -1.0 0.6 1.3 -1.2 0.0
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.5 -0.5 0.1 0.2 -0.4 -0.0
High blood pressure 1.4 3.9 8.5 -2.4 2.5 0.2 -2.9 1.0 1.4
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.4 1.0 -1.1 0.6 0.7 -1.2 -0.3
Multivitamins +/- minerals 0.4 0.5 2.0 -0.3 0.0 -0.5 -0.1 -1.4 -0.6
Stomach or abdominal pain in last month 0.2 0.2 0.5 -0.7 -0.4 0.4 0.3 -0.6 0.3
Supplements: Glucosamine 0.4 0.5 1.9 0.8 -0.1 -0.6 0.0 -0.1 -1.4
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.8 -0.9 0.6 -0.9 -0.5 0.1 0.8
Medication: Atenolol 0.7 0.8 1.7 -0.9 1.3 0.1 -1.2 0.7 0.7
Medication: Levothyroxine sodium 1.7 2.9 4.5 -2.1 1.7 -0.9 -1.9 2.0 1.4
Sitting height 0.2 1.3 5.5 0.6 -0.4 -0.6 0.9 -2.4 0.9
Chronic bronchitis/emphysema (father) 0.3 0.4 1.5 0.4 0.0 -0.6 -0.2 -1.2 -0.6
High blood pressure (mother) 0.7 1.0 2.6 1.0 -0.4 -1.0 0.5 -1.0 -1.6
Body mass index (BMI) 0.6 2.6 9.7 1.6 -0.7 -0.4 0.7 -3.1 -1.5
Impedance of leg (left) 1.7 8.2 28.4 -3.8 1.4 -0.2 -1.8 5.3 1.1
Leg predicted mass (left) 1.4 7.7 21.9 3.1 -2.0 -0.7 2.5 -4.7 -1.8
Trunk fat mass 0.2 0.9 1.9 0.4 -0.5 -1.0 0.7 -1.2 -1.4
Waist circumference 0.1 0.5 1.1 0.4 -0.3 -0.8 0.4 -1.1 -0.8
Number of incorrect matches in round 0.6 1.1 2.2 1.2 -0.9 -0.7 1.0 1.5 -0.5
Past tobacco smoking 1.8 3.3 9.9 -1.9 1.5 3.1 -1.4 1.3 0.4
Alcohol usually taken with meals 1.2 2.0 4.0 -0.8 1.8 0.1 -1.5 1.3 2.0
Nervous feelings 0.1 0.3 0.7 0.3 0.1 0.4 -0.1 0.8 0.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.5 1.1 -1.3 -1.6 1.2 -0.4 -1.1
Hearing difficulty/problems with background noise 0.1 0.2 0.6 -0.2 -0.4 0.3 0.6 -0.8 0.3
Hair/balding pattern: Pattern 2 0.9 1.2 4.8 0.6 -0.8 0.9 0.7 -2.2 0.3
Had menopause 0.6 0.7 1.6 -0.8 0.5 1.3 -0.1 1.2 0.4
Had other major operations 0.3 0.4 1.2 0.5 -0.6 -1.1 0.5 0.2 0.7
Forced vital capacity (FVC) 0.2 0.9 2.7 1.0 -0.6 1.6 0.9 -0.4 0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.6 7.9 2.5 -0.1 -0.7 0.3 -2.8 -1.0
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 2.7 -1.6 1.1 0.1 -1.2 -0.3 -0.4
Qualifications: None of the above 0.2 0.4 0.9 -0.9 0.4 0.0 -0.7 0.9 -0.1
Financial difficulties in last 2 years 2.8 3.8 9.5 0.4 -1.1 -3.1 0.7 -2.6 -2.1
Mouth/teeth dental problems 4.5 6.9 13.2 1.9 -2.7 0.0 2.5 -3.6 -3.3
Heart attack 0.4 0.5 1.0 -0.6 1.0 -0.2 -1.0 0.9 0.1
Allergy 2.1 4.9 7.8 -2.3 2.5 1.7 -2.0 2.8 1.8
Pain all over the body in last month 0.5 0.5 0.8 0.8 -0.9 -0.3 0.9 -0.1 -0.8
Diabetes (self-reported) 0.2 0.3 1.0 0.2 -0.2 -0.7 0.0 -0.5 -1.0
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 2.9 -1.2 0.4 1.7 -0.8 0.3 0.5
Medication: Ramipril 0.4 0.6 1.2 -0.6 0.5 0.0 -0.6 1.1 1.1
Medication: Simvastatin 0.2 0.3 1.3 -0.3 -0.1 -1.2 0.1 0.3 -0.1
Fluid intelligence score 0.2 0.4 1.3 0.2 -0.8 0.5 0.6 -1.1 -0.3
Illnesses of siblings 0.1 0.2 0.4 0.4 0.4 0.7 -0.4 -0.2 0.4
Neuroticism score 0.4 0.8 3.3 1.0 -0.4 -1.8 0.1 -0.4 0.2
Weight 0.7 3.6 9.1 2.0 -1.4 -1.0 1.7 -3.0 -1.5
Impedance of arm (right) 1.1 5.1 21.6 -2.3 1.2 0.3 -1.4 4.7 0.6
Arm fat percentage (right) 0.1 0.5 1.6 0.2 -0.0 -0.1 0.1 -1.1 -1.3
Trunk fat-free mass 1.2 6.6 17.8 2.8 -2.2 -0.5 2.8 -4.2 -1.2
Hip circumference 0.5 2.0 4.1 1.2 -1.1 -0.5 1.3 -2.0 -1.8
Time employed in main current job 0.2 0.2 0.8 -0.5 0.1 -0.3 0.2 0.9 0.6
Alcohol intake versus 10 years previously 0.1 0.1 0.3 0.3 -0.2 0.5 -0.0 0.1 -0.5
Father’s age at death 1.3 1.7 3.5 0.6 -1.6 -0.1 1.7 -0.7 -1.9
Worrier / anxious feelings 0.2 0.3 0.6 0.6 -0.5 0.4 0.3 0.8 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 2.4 1.5 -1.5 -1.0 1.3 -0.9 -0.9
Falls in the last year 1.3 1.7 5.4 -0.1 1.1 -2.3 -1.1 1.6 0.5
Hair/balding pattern: Pattern 3 0.5 0.8 1.6 0.2 -1.1 -1.0 1.3 0.5 -0.7
Number of live births 0.6 0.8 1.7 1.3 -0.6 1.3 0.6 0.7 0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 4.9 1.2 -0.2 2.2 0.6 -1.0 0.1
Pulse rate 0.2 0.3 0.6 -0.1 -0.5 -0.4 0.6 -0.8 -0.6
Happiness 0.9 1.1 4.0 -0.8 -0.7 0.6 0.8 -2.0 -0.6
Noisy workplace 1.0 1.2 2.4 -0.6 1.1 -1.3 -0.9 1.6 0.8
Qualifications: A levels/AS levels or equivalent 0.3 0.6 3.2 0.4 -0.2 1.8 -0.0 -0.2 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 3.2 -0.5 0.4 -1.8 -0.6 -0.2 0.8
Mouth/teeth dental problems: Dentures 0.9 1.6 3.1 -0.6 1.4 0.1 -1.4 1.8 1.5
Asthma 1.5 2.9 11.4 1.1 -1.5 -3.4 0.9 -0.8 -0.9
Medication: Ibuprofen (e.g. Nurofen) 3.1 4.0 8.8 -2.0 2.6 0.7 -3.0 1.2 1.4
Medication: Cholesterol lowering 0.1 0.2 0.8 -0.0 0.4 -0.1 -0.5 0.9 0.3
Depression (self-reported) 0.4 0.5 2.0 0.7 -0.3 -1.4 0.1 -0.5 -0.1
Medication: Lansoprazole 0.4 0.4 2.4 1.5 -0.0 -0.3 0.2 -0.3 0.0
Prospective memory result 1.6 2.0 2.7 -1.5 1.6 1.2 -1.6 1.4 0.9
Lung cancer (father) 0.3 0.4 0.8 -0.9 0.6 0.3 -0.6 -0.1 0.9
Illnesses of mother 0.6 0.7 2.5 0.6 0.3 -0.4 -0.2 1.1 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 3.1 1.4 -0.0 1.1 0.4 -1.8 -0.0
Pulse wave Arterial Stiffness index 0.3 0.4 1.5 -0.7 -0.3 0.3 0.1 0.5 1.2
Impedance of arm (left) 1.3 5.9 22.6 -2.7 1.4 -0.3 -1.6 4.8 0.8
Arm fat mass (right) 0.4 1.6 5.2 1.1 -0.7 -0.5 0.8 -2.3 -1.4
Trunk predicted mass 1.2 6.6 17.6 2.8 -2.1 -0.6 2.8 -4.2 -1.2
Standing height 0.2 1.6 4.7 0.8 -1.5 -1.2 2.2 -0.2 -0.3
Length of working week for main job 0.8 0.9 1.7 -1.3 0.9 -1.0 -1.2 -0.1 0.6
Exposure to tobacco smoke at home 2.3 2.5 3.5 1.8 -1.9 -0.9 1.8 -1.3 -1.7
Breastfed as a baby 0.4 0.4 1.6 0.2 0.3 -0.1 -0.2 0.9 1.3
Tense / ‘highly strung’ 0.5 0.8 2.8 0.7 0.4 -1.7 -0.5 -0.9 -0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.1 3.2 6.8 1.9 -1.5 -2.6 1.1 -2.3 -0.7
Hair/balding pattern: Pattern 4 0.4 0.9 1.8 0.5 -1.1 0.1 1.2 -1.3 -0.9
Birth weight of first child 0.8 1.4 4.2 -2.1 0.9 1.0 -0.6 0.7 1.3
Peak expiratory flow (PEF) 0.9 2.0 4.2 2.0 -0.7 1.6 0.9 -1.9 -0.6
Pulse wave reflection index 0.7 0.9 2.7 -0.8 0.5 0.7 -0.6 0.9 1.6
Ever highly irritable/argumentative for 2 days 0.5 0.5 1.0 -0.9 0.9 -1.0 -0.7 0.4 0.0
Loud music exposure frequency 0.8 0.9 3.4 0.6 -0.8 -1.9 0.8 -0.5 -0.3
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.6 -0.7 0.1 0.8 -0.3 -0.6 -0.3
Mouth/teeth dental problems: Bleeding gums 2.2 2.8 4.8 -1.4 1.8 -0.8 -2.2 1.6 2.1
Blood clot in the leg (DVT) 0.2 0.2 0.5 -0.2 -0.4 -0.7 0.4 -0.5 -0.1
Medication: Paracetamol 0.1 0.2 0.5 -0.7 0.2 0.1 -0.4 0.3 -0.3
Headache pain in last month 1.2 2.1 6.0 -1.3 1.0 1.1 -0.9 1.4 2.4
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 2.1 1.5 -0.8 -0.5 1.1 -0.9 -0.7
Glaucoma (self-reported) 0.9 1.1 2.6 -0.8 1.1 -0.3 -0.8 1.1 1.6
Gout (self-reported) 1.3 1.8 4.6 -2.1 1.2 1.1 -1.2 1.2 0.6
Hypothyroidism/myxoedema (self-reported) 2.5 4.9 10.1 -2.6 1.8 1.0 -2.0 3.2 2.2
Medication: Amlodipine 2.8 3.9 6.1 -2.2 2.5 -0.3 -2.5 1.4 2.0
Medication: Ventolin 100micrograms inhaler 1.3 1.7 6.0 0.6 -1.0 -2.4 0.7 -1.3 -0.8
Birth weight 0.1 0.2 0.5 -0.1 -0.4 0.3 0.7 -0.5 0.1
Chronic bronchitis/emphysema (mother) 0.6 0.6 1.5 1.0 -1.2 -0.4 1.1 -0.3 -0.0
High blood pressure (siblings) 0.1 0.2 0.4 0.5 -0.6 -0.0 0.4 -0.6 -0.2
Forced vital capacity (FVC), Best measure 0.3 1.3 3.3 1.8 -0.9 0.5 1.2 -1.3 -0.3
Body fat percentage 0.1 0.5 1.8 -0.2 -0.1 -0.8 0.0 -0.5 -1.3
Leg fat percentage (right) 0.1 0.5 1.8 0.2 -0.3 -0.6 0.2 -0.7 -1.3
Arm fat-free mass (right) 1.1 5.7 17.6 2.1 -2.0 -1.2 2.4 -4.2 -1.2
Exposure to tobacco smoke outside home 0.3 0.4 1.8 0.4 -0.4 -0.1 0.3 -1.3 -0.7
Comparative body size at age 10 0.6 1.5 3.3 -1.2 1.8 0.8 -1.4 -1.1 0.7
Number of full brothers 0.6 0.8 1.6 1.3 -1.0 1.1 0.7 -0.0 -0.7
Worry too long after embarrassment 0.2 0.3 0.6 0.3 -0.5 -0.3 0.1 -0.8 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.6 0.1 0.1 -0.2 -0.4 -0.7 -0.0
Wheeze or whistling in the chest in last year 0.7 1.2 4.5 0.6 -1.3 -2.1 0.6 -0.3 -0.5
Number of children fathered 1.4 1.6 4.2 0.5 -0.9 2.0 0.9 -1.3 -1.4
Reason for reducing amount of alcohol drunk: Health precaution 3.7 4.4 6.1 -2.4 2.4 -0.2 -2.5 1.7 2.4
Age at first live birth 0.1 0.2 0.4 0.7 -0.5 -0.3 0.5 0.4 0.4
Pulse wave peak to peak time 0.3 0.4 1.3 0.7 0.1 -0.3 0.1 -0.6 -1.1
Health satisfaction 0.4 0.6 1.7 0.1 -0.8 0.9 1.3 -0.2 -0.4
Shortness of breath walking on level ground 0.5 0.6 2.7 -0.5 -0.5 -1.6 0.6 0.5 -0.0
Qualifications: College or University degree 1.5 4.8 9.2 1.4 -2.5 -0.4 2.3 -3.0 -2.4
Eye problems/disorders: None of the above 0.8 0.9 2.0 1.4 -1.1 -0.2 1.2 -0.2 -0.7
Mouth/teeth dental problems: Loose teeth 0.7 0.8 2.1 1.1 -0.3 -0.9 0.7 0.2 1.4
Emphysema/chronic bronchitis 5.9 6.7 9.9 3.1 -2.7 -1.2 2.3 -2.6 -3.2
Medication for pain relief, constipation, heartburn 1.4 2.4 4.4 2.1 -2.1 -0.8 2.1 -0.7 -0.8
Neck or shoulder pain in last month 0.5 0.7 3.6 0.4 -0.1 -1.9 0.1 0.0 0.8
Medication: Blood pressure 0.4 0.6 1.7 -1.3 0.7 0.7 -0.9 -0.6 -0.2
Angina (self-reported) 0.5 0.7 3.7 -0.5 -0.2 -1.9 0.1 0.1 0.4
Migraine (self-reported) 2.6 3.3 7.3 -1.2 2.6 0.3 -2.7 1.0 1.8
Medication: Ibuprofen 4.1 4.9 10.0 -2.4 3.0 0.4 -3.2 1.5 1.5
Medication: Allopurinol 2.5 3.3 5.8 -2.4 1.9 0.6 -1.8 2.2 1.4
Medication: Omeprazole 0.1 0.2 0.3 -0.5 0.0 0.4 0.0 0.6 0.5
Medication: Seretide 50 evohaler 1.4 1.6 3.1 -0.6 1.0 -1.8 -1.3 0.4 1.8
Mean time to correctly identify matches 1.2 2.3 10.8 -0.2 0.9 0.7 -0.9 3.3 0.9
Heart disease (mother) 0.2 0.3 1.4 -0.4 0.1 1.2 -0.0 0.4 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.2 0.2 0.3 -0.3 -0.4 -1.1 -0.2
Whole body fat mass 0.3 1.4 2.9 0.8 -0.8 -1.0 0.9 -1.7 -1.6
Leg fat mass (right) 0.5 1.8 4.5 1.0 -0.9 -0.7 1.0 -2.1 -1.7
Arm predicted mass (right) 1.1 5.7 16.5 2.3 -1.9 -1.3 2.3 -4.1 -1.2
Pulse rate, automated reading 0.9 3.0 6.8 1.9 -1.4 -0.6 1.5 -2.6 -1.7
Alcohol intake frequency. 0.2 0.4 1.2 -0.4 0.5 1.1 -0.5 0.7 -0.3
Comparative height size at age 10 0.4 2.0 7.4 0.6 0.2 -1.2 0.2 2.7 1.6
Number of full sisters 0.2 0.3 0.8 0.8 -0.2 0.9 -0.1 0.2 -0.1
Suffer from ‘nerves’ 0.3 0.5 2.7 1.6 -0.1 0.1 0.1 0.2 0.2
Overall health rating 0.3 0.5 0.9 1.0 -1.0 -0.2 0.8 -0.6 -0.6
Chest pain or discomfort 0.7 1.0 4.1 0.3 -1.1 -2.0 0.8 0.1 0.4
Had major operations 1.1 1.3 4.8 2.2 -0.7 -0.4 0.8 1.2 0.1
Age at last live birth 0.7 1.0 2.1 1.4 -0.9 1.2 0.9 0.6 0.6
Family relationship satisfaction 0.6 0.7 2.3 -1.5 0.6 0.3 -0.5 0.2 1.1
Leg pain on walking 0.6 0.8 2.0 0.7 -1.0 0.3 1.4 0.4 -1.0
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.6 0.1 0.7 -1.9 -0.5 1.6 0.5
Commuting to job workplace: Car/motor vehicle 1.0 1.1 2.3 -0.5 1.5 -1.5 -1.4 0.0 0.5
Illness, injury, bereavement, stress in last 2 years 1.1 1.4 5.1 -0.4 0.5 2.3 -0.2 1.6 0.2
Medication: Aspirin 0.8 1.1 2.5 -1.6 1.4 0.6 -1.1 -0.2 0.6
Supplements: Vitamin C 0.6 0.7 2.1 0.4 -0.6 0.5 0.7 -0.9 -1.4
Knee pain experienced in last month 2.0 3.2 11.7 0.4 -0.9 -3.4 0.5 -2.1 -1.3
Hypertension (Self-reported) 1.2 3.3 6.8 -2.3 2.2 -0.3 -2.6 1.0 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.9 0.9 -0.1 -0.1 0.4 0.3 0.5
Illnesses of father: Heart disease 0.5 0.7 1.3 -0.9 0.7 -0.0 -0.8 1.1 0.8
Illnesses of siblings: Diabetes 0.9 1.2 2.8 0.7 -1.5 -0.8 1.7 -0.7 -0.6
Smoking status: Previous 0.5 0.7 2.6 0.2 -0.6 -1.6 0.6 -0.8 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 4.3 1.0 -1.0 -0.8 1.1 -2.1 -0.5
Whole body fat-free mass 1.3 7.2 20.9 2.9 -2.1 -0.6 2.7 -4.6 -1.5
Leg fat-free mass (right) 1.5 8.1 21.7 3.2 -2.2 -1.0 2.7 -4.7 -2.0
Arm fat percentage (left) 0.2 0.7 1.9 0.2 -0.1 -0.5 0.1 -1.3 -1.4
Average weekly red wine intake 0.4 0.6 1.1 -0.4 1.1 -0.0 -0.9 -0.9 0.8
Handedness (chirality/laterality): Left-handed 0.6 0.7 2.1 0.9 0.3 0.9 -0.2 0.5 1.5
Mood swings 1.1 1.9 4.7 0.4 -1.1 -2.2 1.0 -1.6 -1.4
Loneliness, isolation 1.6 2.3 3.4 1.9 -1.5 -0.7 1.5 -1.3 -1.8
Long-standing illness, disability or infirmity 0.4 0.6 1.5 0.5 -1.2 -0.9 0.8 -0.1 -0.8
Ever had bowel cancer screening 0.7 0.8 3.9 -0.4 0.4 0.4 -0.1 2.0 0.7
Diabetes diagnosed by doctor 0.4 0.6 1.6 0.6 -0.5 -0.5 0.4 -1.0 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.0 0.2 0.4 -0.1 -0.4 1.0 0.9
Friendships satisfaction 0.6 0.7 1.4 -0.4 -0.9 -0.8 1.2 -1.2 0.4
Qualifications: nursing, teaching 0.5 0.8 2.2 0.3 -1.4 -0.2 1.5 0.6 0.3
Commuting to job workplace: Walk 0.7 0.8 3.7 0.0 -0.6 0.2 0.6 1.9 0.4
Eye problems/disorders: Cataract 1.8 2.1 3.7 -1.9 1.4 1.9 -1.4 0.2 1.2
Mouth/teeth dental problems: Mouth ulcers 2.1 3.4 6.6 -2.6 1.3 1.2 -0.8 2.2 2.3
Medication for cholesterol 1.5 2.3 3.5 1.3 -1.6 1.0 1.7 -1.9 -1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.9 -0.2 0.1 0.8 0.0 1.0 0.8
Back pain experienced in last month 0.1 0.2 0.6 -0.1 -0.4 -0.8 0.3 -0.3 -0.2
Mineral and other dietary supplements 0.9 1.2 3.0 -1.4 0.9 0.5 -0.9 0.7 1.7
Breast cancer (self-reported) 0.2 0.3 1.1 1.0 0.3 -0.4 -0.5 -0.1 0.2
Asthma (self-reported) 1.5 3.0 11.8 0.9 -1.7 -3.4 1.1 -0.7 -0.9
Osteoporosis (self-reported) 1.3 1.6 4.7 -1.6 0.9 0.8 -0.7 2.2 0.7
Osteoarthritis (self-reported) 0.4 0.5 1.1 -0.2 0.9 -0.3 -1.1 1.1 0.2
Medication: Aspirin 0.6 0.8 1.6 -1.2 1.3 0.4 -1.0 -0.4 0.5
Medication: Gliclazide 0.1 0.1 0.4 0.3 0.1 -0.6 -0.1 0.3 -0.1
Illnesses of father: None of the above (group 1) 0.7 0.9 1.7 1.3 -1.0 -1.0 1.0 -0.5 -0.5
Smoking status: Current 1.0 1.6 5.2 2.3 -0.7 -1.6 0.4 1.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.2 2.6 6.1 -1.4 2.5 0.5 -2.1 -1.4 1.0
Whole body water mass 1.4 7.7 21.4 3.0 -2.2 -0.8 2.8 -4.6 -1.5
Leg predicted mass (right) 1.6 8.8 22.8 3.3 -2.3 -1.0 2.9 -4.8 -2.1
Arm fat mass (left) 0.4 1.7 5.6 1.1 -0.6 -0.6 0.8 -2.4 -1.4
Number of self-reported non-cancer illnesses 0.5 0.9 1.8 -1.4 0.8 -0.4 -1.0 1.1 0.6
Average weekly champagne plus white wine intake 0.4 0.5 1.1 0.5 -0.9 -0.9 1.0 0.3 -0.3
Miserableness 0.2 0.4 0.9 0.8 -0.9 -0.1 0.8 -0.4 -0.3
Guilty feelings 0.4 0.6 2.4 0.1 0.0 -1.5 -0.1 -0.3 0.9
Wears glasses or contact lenses 0.2 0.3 0.9 -0.9 0.4 -0.5 -0.1 0.4 0.4
Ever taken oral contraceptive pill 2.0 2.2 4.8 1.4 -1.7 -0.5 1.5 -1.0 -2.2
Hearing aid user 0.5 0.6 3.0 -0.4 0.1 1.7 -0.1 0.4 -0.0
Mother’s age at death 0.4 0.5 0.8 0.9 -0.8 0.1 0.8 -0.3 -0.9
Financial situation satisfaction 0.8 0.9 2.3 -1.2 0.1 -1.5 -0.1 -1.0 -0.9
Tinnitus: Yes, now most or all of the time 2.6 3.1 6.8 2.2 -2.6 0.2 2.6 -0.1 -0.2
Commuting to job workplace: Public transport 0.3 0.3 0.6 0.2 -0.6 -0.7 0.7 0.2 -0.8
Eye problems/disorders: Glaucoma 0.4 0.5 1.4 -0.4 0.8 -0.3 -0.6 0.2 1.2
Medication: Blood pressure 1.3 2.5 4.6 -1.1 1.4 -1.0 -1.8 2.1 1.8
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.0 -0.7 0.4 0.3 -0.4 1.4 1.2
Supplements: Fish oil (including cod liver oil) 0.9 1.2 2.6 0.6 -1.0 -0.2 1.2 -1.2 -1.6
High cholesterol (Self-reported) 0.9 1.5 5.9 0.1 1.1 -2.4 -0.7 0.2 1.2
Medication: Bendroflumethiazide 0.4 0.6 1.1 -0.6 0.9 0.5 -1.1 0.6 0.7
Medication: Paracetamol 0.3 0.5 1.7 -1.3 0.5 0.5 -0.6 0.5 -0.2
Medication: Lisinopril 0.2 0.3 0.9 -0.5 -0.5 1.0 0.4 0.0 -0.6
Medication: Atorvastatin 0.3 0.4 0.8 0.1 0.4 -0.9 -0.4 0.9 0.7
Illnesses of father: High blood pressure 0.4 0.5 1.4 -1.2 0.7 0.1 -0.8 0.5 0.4
Alcohol drinker status: Never 0.3 0.4 1.1 0.7 -0.2 0.6 0.4 -0.2 -1.1
Ever smoked 1.9 3.3 9.2 1.7 -1.4 -3.0 1.2 -1.9 -0.8
Basal metabolic rate 1.3 7.1 19.4 2.9 -2.1 -0.7 2.6 -4.4 -1.7
Leg fat percentage (left) 0.2 0.7 2.5 0.4 -0.6 -0.8 0.6 -0.6 -1.6
Arm fat-free mass (left) 1.1 5.5 16.1 2.5 -1.9 -0.9 2.4 -4.0 -1.1
Number of operations (self-reported) 1.3 1.9 5.0 1.0 0.5 -0.3 -0.7 2.1 2.2
Average weekly beer plus cider intake 1.4 2.0 3.2 1.3 -1.5 -1.8 1.3 -1.3 -1.1
Irritability 0.7 1.2 5.4 0.2 -0.8 -2.3 0.8 0.1 -0.4
Risk taking 1.1 1.6 3.5 1.9 -1.1 0.3 1.3 -1.4 -1.2
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.9 -0.4 0.4 0.1 -0.3 -0.5 -1.0
Fractured/broken bones in last 5 years 1.1 1.5 3.6 -1.3 -0.3 1.7 0.4 1.9 0.4
Age started oral contraceptive pill 1.0 1.3 2.7 -1.0 1.3 0.1 -1.2 1.6 1.0
Diastolic blood pressure, automated reading 0.9 2.7 6.2 -2.5 2.1 0.5 -2.3 0.2 0.3
Ever depressed for a whole week 0.6 0.7 1.2 0.7 -0.6 -1.1 0.6 -0.9 -1.0
Unable to work because of sickness or disability 0.8 1.0 3.0 -0.3 0.5 -1.7 -0.6 0.8 1.2
Commuting to job workplace: Cycle 1.1 1.3 3.1 1.6 -0.9 -0.1 0.8 -1.8 -0.9
Myopia 0.2 0.3 0.8 0.7 0.2 0.9 0.2 0.4 0.6
Vascular/heart problems diagnosed by doctor 1.7 4.7 9.8 2.4 -2.8 -0.2 3.1 -1.7 -1.4
Cholesterol lowering medication 0.5 0.7 3.3 -0.4 0.7 -1.8 -0.5 -0.1 0.4
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 -0.5 0.3 0.3 -0.2 0.4 0.1
Pain experienced in last month 1.0 1.7 9.4 -0.1 0.3 3.1 -0.0 0.7 -0.4
Supplements: Calcium 0.3 0.4 0.8 0.4 0.9 0.5 -0.8 0.6 0.2
Basal cell carcinoma (self-reported) 0.2 0.2 0.8 0.5 0.0 -0.5 0.0 -0.9 0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.7 -0.5 0.8 0.0 -0.8 0.7 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 -0.1 -0.2 -0.3 0.2 -0.1 0.1
Heart disease (siblings) 3.4 4.2 6.7 -2.3 2.6 -1.1 -2.5 1.7 1.7
Alcohol drinker status: Previous 0.5 0.6 1.3 0.1 -1.0 -0.5 0.6 -0.7 -1.1
Pack years of smoking 0.3 0.4 1.0 -1.0 -0.1 -0.1 0.1 0.7 0.9
Impedance of whole body 1.6 8.2 28.9 -3.6 1.6 -0.3 -1.9 5.4 1.1
Leg fat mass (left) 0.5 2.1 4.3 1.1 -1.1 -0.9 1.3 -2.1 -1.8
Arm predicted mass (left) 1.1 5.8 16.5 2.7 -1.9 -0.8 2.4 -4.1 -1.2