Hub : Genes

NELFA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Skin Not Sun Exposed Suprapubic 0.174 0.0610 2.7e-03 0.047 NA 0.016 NA 0.035 1.3e-03 NA 4.5e-02 NA 4.8e-03
2 GTEx Thyroid 0.145 0.0420 1.2e-04 0.094 NA 0.082 NA 0.086 1.2e-07 NA 7.4e-07 NA 4.0e-07
3 ROSMAP Brain Pre-frontal Cortex 0.249 0.0507 4.4e-10 0.166 0.099 0.156 0.16 0.165 8.3e-21 1.1e-12 1.4e-19 4.3e-20 1.0e-20

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.3 0.4 0.9 -0.9 0.7 0.0
Bipolar Disorder or Schizophrenia 0.3 0.7 1.7 -1.3 0.7 0.0
Depressed Affect (Nagel 2018) 1.9 3.9 7.2 1.2 -2.7 1.8
Depression (Nagel 2018) 0.9 1.4 2.8 1.2 -1.7 -0.1
Intelligence (Savage-Jansen 2018) 0.6 1.8 4.2 -1.0 2.1 -0.2
Neuroticism (Nagel 2018) 1.0 2.3 5.6 1.2 -2.4 -0.1
Schizophrenia (2018) 0.2 0.3 0.9 -0.9 0.3 0.0
Schizophrenia vs Biploar Disorder 0.1 0.1 0.4 0.6 0.1 0.0
Worry (Nagel 2018) 0.6 1.2 2.0 0.9 -1.4 -0.9
Alzheimer’s Disease (in mother) 5.1 5.9 9.0 -2.5 1.5 -3.0
Alzheimer’s Disease (in father) 0.6 0.7 1.5 -0.7 0.2 1.2
Alzheimer’s Disease (including proxy) 1.5 2.2 5.5 -2.3 0.7 -0.8
Crohns Disease (2017) 0.0 0.1 0.2 0.0 0.4 0.1
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 0.7 -0.4 -0.0
Ulcerative Colitis (UC) 0.1 0.3 0.4 0.7 -0.5 -0.2
Major Depression (MDD) 0.4 0.5 1.5 1.2 0.0 0.0
Reaction Time 0.7 1.4 2.3 -1.1 1.5 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.7 1.2 -0.8 1.1 -0.4
Breast Cancer 5.6 13.5 24.9 3.6 -1.7 5.0
Ovarian Cancer 1.1 1.4 2.1 1.4 -1.2 -0.9
Prostate Cancer 1.4 2.0 5.1 -0.6 0.6 -2.3
Age at First Birth 4.4 6.5 10.7 -3.3 2.8 -1.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.9 1.3 2.2 0.7 -1.1 1.5
Coronary Artery Disease (CAD) 1.7 2.1 3.4 1.8 -1.7 0.0
Crohns Disease (2012) 0.2 0.3 1.0 1.0 -0.0 0.0
Mean Putamen Volume 0.1 0.2 0.2 -0.5 0.1 -0.5
Fasting Glucose 0.7 0.9 1.4 -1.2 0.8 -0.8
HbA1C 0.5 0.5 1.2 0.4 1.1 0.5
HDL Cholesterol 1.4 2.3 2.7 -1.6 1.3 -1.7
LDL Cholesterol 0.6 0.9 2.0 -0.8 0.3 -1.4
Lupus 1.4 2.1 3.8 -2.0 1.5 0.0
Neuroticism (2016) 2.9 4.2 5.5 2.4 -2.3 -1.4
Primary Biliary Cirrhosis 1.4 1.9 2.7 -0.6 1.7 1.6
Rheumatoid Arthritis 0.8 1.1 1.8 1.3 -1.2 0.6
Schizophrenia (2014) 0.1 0.2 0.6 -0.4 0.7 0.0
Triglycerides 1.8 2.9 5.2 2.3 -1.6 0.9
Type 2 Diabetes (T2D) (2012) 0.9 1.0 1.9 1.4 -1.1 0.0
Ulcerative Colitis 0.1 0.1 0.3 0.6 -0.3 0.0
Blood Eosinophil Count 0.1 0.5 0.8 0.8 0.0 0.9
Blood Platelet Count 0.2 1.8 2.5 -1.5 -0.7 -1.6
Blood Red Count 0.3 3.1 8.9 0.5 0.0 3.0
Blood White Count 0.1 0.7 0.9 -1.0 0.6 -0.9
Heel T-Score 0.2 1.4 4.1 0.2 0.4 2.0
BMI 0.1 0.5 1.4 -0.2 -1.2 0.1
Height 0.9 18.2 45.2 -2.9 1.0 -6.7
Waist Hip Ratio (WHR) 1.4 6.1 12.4 -2.1 3.5 -1.3
Systolic Blood Pressure 0.6 2.8 3.7 -1.6 1.9 -1.4
Smoking Status 1.0 2.4 6.9 0.5 0.1 -2.6
Allergy or Eczema 0.1 0.2 0.5 -0.2 0.4 0.7
Cardiovascular Disease 0.3 0.9 2.2 -0.1 0.7 -1.5
Hypothyroidism (self reported) 0.2 0.4 1.1 0.5 -1.1 0.1
Respiratory disease 0.4 0.9 1.5 0.1 1.1 -1.2
Type 2 Diabetes (T2D) (2018) 1.7 3.2 6.4 1.8 0.3 2.5
Lung FEV1/FVC ratio 0.5 2.6 5.0 0.9 -1.4 2.2
Lung FVC 0.5 2.4 4.9 1.5 -0.0 2.2
Neuroticism 0.4 0.9 2.1 0.4 -1.4 -0.7
Chronotype (morning person) 0.7 1.6 2.8 1.3 -0.4 1.7
Hair Pigment 0.0 0.8 2.1 0.4 -0.2 -1.5
Tanning 0.0 0.2 0.3 0.4 0.1 -0.6
Hand grip strength (left) 0.1 0.3 0.7 -0.8 -0.0 -0.4
Number of treatments/medications taken 1.4 2.4 4.5 2.1 -1.2 1.2
Average weekly spirits intake 2.0 2.4 5.1 -1.4 2.3 0.3
Sensitivity / hurt feelings 0.6 1.0 2.8 0.4 -1.7 -0.5
Frequency of depressed mood in last 2 weeks 2.5 3.5 5.6 2.4 -2.0 0.9
Hearing difficulty/problems: Yes 0.6 0.9 2.5 -0.1 0.4 1.6
Relative age of first facial hair 0.4 0.8 2.1 0.5 -1.5 0.3
Other serious medical condition/disability diagnosed by doctor 0.9 1.1 1.7 -0.5 1.2 -1.3
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.2 0.5 0.5
Ever had hysterectomy (womb removed) 0.9 1.1 2.7 -0.3 0.7 -1.6
Systolic blood pressure, automated reading 0.0 0.0 0.0 -0.0 0.0 0.1
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 1.4 -0.5 0.2
Angina 0.0 0.0 0.0 0.2 -0.1 0.1
Medication for hormone replacement therapy 0.2 0.2 0.4 0.1 0.6 -0.3
Vitamin and mineral supplements 2.0 2.7 4.2 -1.8 0.7 -2.0
Supplements: Zinc 0.4 0.4 1.2 -0.3 0.2 -1.1
Medication: Co-codamol 0.6 0.8 1.0 1.0 -0.6 -0.9
Medication: Metformin 1.4 2.0 4.6 0.4 1.1 2.1
Diabetes (father) 0.1 0.1 0.3 0.0 0.5 0.4
Diabetes (mother) 0.5 0.6 1.8 1.3 0.3 0.3
Severe depression (siblings) 1.2 1.3 2.3 -0.3 -1.3 -1.5
Pack years adult smoking proportion 1.4 2.1 6.2 -0.4 -0.2 -2.5
Impedance of leg (right) 0.0 0.2 0.4 -0.3 0.3 -0.6
Leg fat-free mass (left) 0.3 1.7 3.6 -1.1 0.4 -1.9
Trunk fat percentage 0.1 0.2 0.3 0.1 0.6 -0.6
Hand grip strength (right) 0.2 0.5 0.7 -0.8 -0.5 -0.8
Townsend deprivation index at recruitment 0.7 0.9 1.7 -0.2 1.3 -1.0
Current tobacco smoking 1.1 1.8 5.4 0.3 -0.1 -2.3
Average weekly fortified wine intake 0.8 0.9 1.3 -1.0 0.6 -1.1
Maternal smoking around birth 1.2 1.7 3.4 1.9 -1.3 -0.1
Fed-up feelings 3.4 6.2 10.5 2.4 -3.2 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.8 2.7 1.6 -1.6 -0.4
Relative age voice broke 3.6 5.5 7.7 2.5 -2.8 1.5
Taking other prescription medications 0.7 1.1 1.8 1.4 -1.1 0.4
Age when periods started (menarche) 0.1 0.2 0.5 0.1 -0.2 0.7
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.1 -0.2 1.4 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.4 4.6 1.2 -2.0 2.1
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 2.4 -1.5 -0.1 -1.5
Qualifications: CSEs or equivalent 0.3 0.3 0.5 0.5 -0.5 0.7
Serious illness, injury or assault to yourself 0.8 1.0 2.0 -0.6 1.4 -0.8
High blood pressure 0.1 0.4 0.6 0.7 -0.7 0.2
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.2 -0.6 1.1 -0.4
Multivitamins +/- minerals 1.9 2.4 3.3 1.7 -1.0 1.8
Stomach or abdominal pain in last month 0.4 0.5 0.7 0.9 0.3 -0.7
Supplements: Glucosamine 0.9 1.2 1.9 -0.5 1.2 -1.4
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 2.4 1.0 -1.5 1.6
Medication: Atenolol 0.8 1.0 1.9 1.4 0.1 1.0
Medication: Levothyroxine sodium 0.4 0.8 1.6 0.7 -0.4 1.3
Sitting height 0.4 2.6 6.9 -0.9 -0.4 -2.6
Chronic bronchitis/emphysema (father) 0.7 0.9 1.4 0.3 1.2 -1.1
High blood pressure (mother) 0.9 1.3 2.6 -1.6 0.5 -1.0
Body mass index (BMI) 0.3 1.1 1.8 1.3 -0.9 0.9
Impedance of leg (left) 0.0 0.1 0.3 -0.2 0.2 -0.5
Leg predicted mass (left) 0.3 1.7 3.9 -1.1 0.4 -2.0
Trunk fat mass 0.1 0.6 1.5 -0.0 0.4 -1.2
Waist circumference 0.3 1.2 1.7 -0.8 1.3 -1.2
Number of incorrect matches in round 1.0 1.7 2.4 -1.0 1.5 -1.3
Past tobacco smoking 0.5 1.0 2.7 -0.5 -0.0 1.6
Alcohol usually taken with meals 0.1 0.1 0.2 -0.2 -0.5 0.3
Nervous feelings 0.4 0.7 1.4 0.7 -1.2 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 3.8 1.9 -1.0 -0.2
Hearing difficulty/problems with background noise 0.3 0.5 1.2 0.3 0.6 1.1
Hair/balding pattern: Pattern 2 3.2 4.1 8.6 -1.9 2.9 0.1
Had menopause 1.5 1.9 4.9 -0.7 2.2 0.6
Had other major operations 0.7 0.8 2.0 -0.0 0.7 -1.4
Forced vital capacity (FVC) 0.3 1.3 2.1 -1.4 1.0 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.7 3.4 1.2 -1.8 1.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 1.8 0.4 -1.4 -0.5
Qualifications: None of the above 1.1 2.3 3.0 1.7 -1.7 -1.0
Financial difficulties in last 2 years 0.5 0.7 0.9 0.9 -0.8 -0.8
Mouth/teeth dental problems 1.3 2.0 2.5 -1.6 1.4 1.2
Heart attack 0.6 0.8 1.9 1.4 -0.5 0.6
Allergy 0.4 0.9 1.5 0.4 -1.2 0.9
Pain all over the body in last month 0.5 0.6 1.0 -0.7 1.0 -0.4
Diabetes (self-reported) 1.4 2.1 4.1 1.5 -0.0 2.0
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 1.8 0.5 0.3 1.3
Medication: Ramipril 0.1 0.1 0.1 -0.4 0.1 -0.4
Medication: Simvastatin 1.0 1.5 2.2 1.4 0.3 1.5
Fluid intelligence score 0.4 0.9 1.1 -1.1 1.0 -0.7
Illnesses of siblings 2.0 2.9 4.0 -2.0 1.8 -1.1
Neuroticism score 0.7 1.5 3.6 0.8 -1.9 -0.3
Weight 0.2 0.9 2.5 -0.5 0.1 -1.6
Impedance of arm (right) 0.5 2.1 3.4 -1.7 1.8 -0.3
Arm fat percentage (right) 0.1 0.2 0.5 0.7 -0.1 0.3
Trunk fat-free mass 0.5 3.0 7.6 -1.1 0.2 -2.8
Hip circumference 0.2 0.9 1.9 -0.7 0.3 -1.4
Time employed in main current job 0.6 0.6 1.3 0.8 -1.2 -0.1
Alcohol intake versus 10 years previously 0.1 0.1 0.3 0.5 0.1 0.2
Father’s age at death 2.0 2.7 5.5 -1.6 2.4 0.2
Worrier / anxious feelings 0.3 0.6 0.8 0.8 -0.9 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 3.1 1.8 -1.2 -0.2
Falls in the last year 2.1 2.8 4.3 1.9 -2.1 0.6
Hair/balding pattern: Pattern 3 1.2 1.8 3.4 1.9 -1.4 0.4
Number of live births 1.2 1.7 3.0 1.7 -1.4 -0.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 1.7 -1.3 0.8 0.3
Pulse rate 0.2 0.3 0.8 -0.1 0.1 -0.9
Happiness 0.7 0.9 2.6 -0.0 -1.6 -0.0
Noisy workplace 1.2 1.5 2.9 1.7 -1.3 0.1
Qualifications: A levels/AS levels or equivalent 1.3 2.9 5.6 -2.4 1.8 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.7 0.9 -0.1 0.4
Mouth/teeth dental problems: Dentures 1.0 1.6 2.3 0.8 -1.4 -1.5
Asthma 0.7 1.4 3.7 0.3 0.7 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.2 1.1 -0.8 -0.9
Medication: Cholesterol lowering 0.8 1.2 2.3 1.5 -0.1 1.1
Depression (self-reported) 3.3 4.0 7.4 2.7 -1.9 1.0
Medication: Lansoprazole 0.5 0.5 0.6 -0.7 0.8 0.7
Prospective memory result 0.2 0.2 0.4 0.7 -0.3 0.4
Lung cancer (father) 0.1 0.1 0.3 0.0 -0.6 -0.1
Illnesses of mother 0.6 0.7 1.5 0.5 -1.2 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.6 0.8 -0.7 0.9 0.8
Pulse wave Arterial Stiffness index 0.5 0.6 0.8 0.9 -0.9 -0.3
Impedance of arm (left) 0.5 2.3 3.3 -1.8 1.8 -0.7
Arm fat mass (right) 0.0 0.1 0.2 0.4 -0.1 -0.5
Trunk predicted mass 0.6 3.2 8.1 -1.2 0.1 -2.8
Standing height 1.5 14.5 24.4 -3.9 2.1 -4.9
Length of working week for main job 0.3 0.3 0.8 0.4 -0.9 -0.3
Exposure to tobacco smoke at home 0.5 0.5 0.9 1.0 0.0 0.8
Breastfed as a baby 1.4 1.7 3.1 -1.4 1.8 -0.1
Tense / ‘highly strung’ 0.9 1.5 2.4 1.6 -0.8 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 1.9 3.1 1.7 -1.5 -0.7
Hair/balding pattern: Pattern 4 0.3 0.6 1.8 0.2 -1.3 0.1
Birth weight of first child 0.0 0.1 0.1 0.3 0.2 0.2
Peak expiratory flow (PEF) 0.5 1.1 3.1 0.3 0.1 1.8
Pulse wave reflection index 1.8 2.2 2.9 1.7 -1.6 1.1
Ever highly irritable/argumentative for 2 days 1.1 1.4 1.8 1.3 -1.3 -0.7
Loud music exposure frequency 0.2 0.2 0.3 -0.3 0.4 -0.5
Qualifications: O levels/GCSEs or equivalent 1.9 3.1 5.4 -2.3 1.8 0.9
Mouth/teeth dental problems: Bleeding gums 0.8 1.0 2.4 1.6 -0.6 0.4
Blood clot in the leg (DVT) 0.1 0.1 0.1 0.3 -0.3 0.3
Medication: Paracetamol 2.6 4.4 7.0 2.6 -2.0 1.4
Headache pain in last month 0.7 1.2 2.0 1.4 -1.2 0.3
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.4 -1.2 -0.2 -0.4
Glaucoma (self-reported) 0.6 0.7 2.1 0.2 -0.0 -1.5
Gout (self-reported) 0.1 0.1 0.3 0.0 -0.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.5 0.5 -0.7 0.5
Medication: Amlodipine 1.4 2.0 2.8 -1.3 1.2 -1.7
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.8 -0.1 -0.1 0.9
Birth weight 0.0 0.1 0.2 0.2 -0.4 0.2
Chronic bronchitis/emphysema (mother) 2.4 2.8 3.9 2.0 -2.0 0.7
High blood pressure (siblings) 1.0 1.4 1.4 1.2 -1.2 1.2
Forced vital capacity (FVC), Best measure 0.4 1.4 2.6 -1.2 1.6 -0.4
Body fat percentage 0.0 0.2 0.4 0.6 0.1 -0.3
Leg fat percentage (right) 0.2 0.8 1.7 1.3 -0.8 -0.2
Arm fat-free mass (right) 0.3 1.8 4.9 -0.6 -0.3 -2.2
Exposure to tobacco smoke outside home 1.6 2.1 2.7 1.7 -1.2 -1.5
Comparative body size at age 10 0.0 0.1 0.4 0.0 0.2 0.6
Number of full brothers 4.4 5.5 10.3 2.5 -3.2 0.2
Worry too long after embarrassment 1.1 1.8 2.8 -1.7 0.9 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.2 3.6 0.1 -0.4 -1.9
Wheeze or whistling in the chest in last year 0.3 0.6 1.6 0.1 0.2 -1.3
Number of children fathered 3.4 3.9 7.3 2.7 -2.0 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 -0.7 -0.3 0.2
Age at first live birth 0.3 0.6 1.5 -1.2 0.5 0.0
Pulse wave peak to peak time 0.8 0.9 1.5 -1.2 1.0 -0.2
Health satisfaction 0.8 1.1 3.1 -0.3 0.3 -1.8
Shortness of breath walking on level ground 0.8 0.9 2.0 0.9 -1.4 0.2
Qualifications: College or University degree 0.6 1.8 3.1 -1.5 1.8 0.0
Eye problems/disorders: None of the above 0.3 0.4 0.7 0.4 -0.5 0.8
Mouth/teeth dental problems: Loose teeth 2.3 2.7 5.7 -1.3 0.9 -2.4
Emphysema/chronic bronchitis 0.2 0.2 0.7 0.0 0.0 -0.8
Medication for pain relief, constipation, heartburn 3.5 5.9 10.2 -3.2 2.7 -0.5
Neck or shoulder pain in last month 2.1 2.9 3.6 1.9 -1.9 -1.3
Medication: Blood pressure 0.2 0.3 0.6 -0.0 0.8 -0.6
Angina (self-reported) 0.2 0.2 0.3 0.5 -0.5 0.4
Migraine (self-reported) 0.2 0.3 0.7 0.2 -0.2 0.8
Medication: Ibuprofen 0.9 1.1 1.4 1.2 -0.8 -1.1
Medication: Allopurinol 0.3 0.4 0.5 0.6 -0.4 0.7
Medication: Omeprazole 0.2 0.3 0.8 0.2 0.1 0.9
Medication: Seretide 50 evohaler 0.0 0.0 0.1 0.2 0.2 0.2
Mean time to correctly identify matches 0.6 1.2 3.0 -0.7 1.7 -0.2
Heart disease (mother) 0.3 0.3 0.5 0.7 0.3 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.7 4.4 7.8 1.7 -1.6 2.8
Whole body fat mass 0.1 0.3 0.8 0.2 0.2 -0.9
Leg fat mass (right) 0.1 0.4 0.6 0.8 -0.5 -0.6
Arm predicted mass (right) 0.2 1.2 3.3 -0.3 -0.5 -1.8
Pulse rate, automated reading 0.1 0.4 0.6 -0.3 0.7 0.8
Alcohol intake frequency. 0.9 2.1 6.0 2.4 -0.5 -0.3
Comparative height size at age 10 2.4 13.2 15.4 -3.9 3.2 -3.7
Number of full sisters 2.2 2.7 4.3 2.1 -1.7 0.8
Suffer from ‘nerves’ 1.8 2.9 6.2 1.6 -2.5 -0.1
Overall health rating 2.4 5.1 9.0 3.0 -2.3 1.1
Chest pain or discomfort 0.3 0.4 1.2 -0.0 1.1 0.3
Had major operations 1.5 1.7 3.0 -0.6 1.4 -1.7
Age at last live birth 0.1 0.2 0.5 -0.7 0.0 -0.1
Family relationship satisfaction 1.1 1.4 3.8 0.3 -1.9 -0.4
Leg pain on walking 1.2 1.5 3.1 1.1 -1.8 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.6 -1.3 0.6 -0.7
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.9 0.5 -0.9 0.6
Illness, injury, bereavement, stress in last 2 years 1.4 1.7 2.1 -1.4 1.5 0.9
Medication: Aspirin 1.6 2.0 3.1 1.8 -1.7 0.1
Supplements: Vitamin C 0.1 0.1 0.2 0.5 -0.0 0.2
Knee pain experienced in last month 0.7 1.1 3.2 -0.2 -0.1 -1.8
Hypertension (Self-reported) 0.0 0.1 0.2 0.4 -0.2 0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.8 -0.3 0.9 -0.2
Illnesses of father: Heart disease 0.4 0.5 1.5 -0.3 0.0 1.2
Illnesses of siblings: Diabetes 0.4 0.5 0.9 0.9 0.3 0.7
Smoking status: Previous 0.2 0.4 0.9 0.0 0.4 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 1.2 2.6 4.0 -1.7 0.9 -2.0
Whole body fat-free mass 0.4 2.3 5.8 -1.1 0.1 -2.4
Leg fat-free mass (right) 0.3 1.5 3.3 -1.0 0.2 -1.8
Arm fat percentage (left) 0.0 0.2 0.6 0.7 -0.1 0.0
Average weekly red wine intake 0.1 0.2 0.2 0.4 0.4 0.3
Handedness (chirality/laterality): Left-handed 7.9 9.5 12.2 -3.5 2.6 -3.1
Mood swings 2.0 3.7 7.3 1.5 -2.7 1.3
Loneliness, isolation 1.9 2.6 5.1 1.5 -0.6 2.3
Long-standing illness, disability or infirmity 2.3 3.5 7.7 2.8 -1.6 0.3
Ever had bowel cancer screening 0.6 0.7 2.1 -0.0 0.3 -1.5
Diabetes diagnosed by doctor 1.5 2.5 3.8 1.9 -0.1 1.9
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.9 2.3 -1.4 1.1 -1.5
Friendships satisfaction 1.6 2.0 4.8 1.0 -2.2 -0.2
Qualifications: nursing, teaching 0.2 0.3 0.5 -0.4 0.4 -0.7
Commuting to job workplace: Walk 3.0 3.2 5.7 -1.7 2.4 -1.0
Eye problems/disorders: Cataract 2.1 2.4 3.6 -1.5 1.2 -1.9
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 0.2 0.0 -0.2
Medication for cholesterol 0.3 0.4 1.2 -1.1 -0.2 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.1 2.3 0.8 -0.7 1.5
Back pain experienced in last month 0.8 1.2 3.2 0.0 -0.5 -1.8
Mineral and other dietary supplements 0.5 0.7 1.4 0.4 -0.6 1.2
Breast cancer (self-reported) 2.1 2.5 4.9 -1.5 0.7 -2.2
Asthma (self-reported) 0.7 1.3 3.4 0.4 0.6 -1.8
Osteoporosis (self-reported) 0.2 0.3 0.8 0.0 -0.4 0.9
Osteoarthritis (self-reported) 0.8 1.1 1.7 0.0 -1.3 -1.3
Medication: Aspirin 1.3 1.7 3.0 1.5 -1.7 0.2
Medication: Gliclazide 1.9 2.2 3.2 1.8 -0.2 1.8
Illnesses of father: None of the above (group 1) 0.6 0.8 1.6 0.9 -1.3 0.2
Smoking status: Current 1.0 1.6 4.3 0.6 -0.5 -2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.6 2.5 -0.5 1.6 1.4
Whole body water mass 0.4 2.4 6.0 -1.1 0.2 -2.4
Leg predicted mass (right) 0.3 1.6 3.6 -1.1 0.3 -1.9
Arm fat mass (left) 0.0 0.2 0.4 0.4 -0.2 -0.6
Number of self-reported non-cancer illnesses 0.5 0.9 2.2 1.5 -0.7 -0.1
Average weekly champagne plus white wine intake 0.1 0.1 0.1 -0.4 0.3 -0.1
Miserableness 0.5 0.8 1.3 -0.1 -1.1 1.1
Guilty feelings 1.0 1.5 2.8 1.1 -1.7 -0.8
Wears glasses or contact lenses 0.3 0.3 0.6 -0.3 0.8 0.5
Ever taken oral contraceptive pill 0.5 0.5 1.4 -0.3 0.3 -1.2
Hearing aid user 0.2 0.2 0.6 -0.0 0.8 0.1
Mother’s age at death 0.8 1.0 1.8 -0.9 1.4 0.5
Financial situation satisfaction 0.4 0.5 1.0 -1.0 -0.4 0.5
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.0 -0.9 1.0 -0.8
Commuting to job workplace: Public transport 0.1 0.1 0.3 0.2 -0.1 0.5
Eye problems/disorders: Glaucoma 0.8 1.0 2.8 0.4 0.0 -1.7
Medication: Blood pressure 0.1 0.1 0.2 -0.1 0.5 -0.4
Pain type(s) experienced in last month: Hip pain 1.6 2.0 3.3 1.8 -1.5 0.7
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.4 -0.2 -0.5 -1.6
High cholesterol (Self-reported) 0.7 1.2 2.9 1.7 -0.3 0.9
Medication: Bendroflumethiazide 0.1 0.1 0.3 0.2 0.5 -0.2
Medication: Paracetamol 2.2 3.4 5.5 2.3 -2.0 0.8
Medication: Lisinopril 0.5 0.7 1.3 -0.0 0.9 -1.1
Medication: Atorvastatin 0.0 0.0 0.0 0.0 0.1 -0.1
Illnesses of father: High blood pressure 0.6 0.7 1.1 -0.9 1.0 -0.5
Alcohol drinker status: Never 0.4 0.5 1.0 0.4 1.0 -0.6
Ever smoked 0.4 0.8 2.0 -0.3 0.4 -1.4
Basal metabolic rate 0.4 2.1 5.5 -0.9 0.1 -2.3
Leg fat percentage (left) 0.2 0.6 1.3 1.1 -0.7 -0.3
Arm fat-free mass (left) 0.3 1.5 4.2 -0.5 -0.3 -2.1
Number of operations (self-reported) 4.3 6.3 13.8 -1.5 1.7 -3.7
Average weekly beer plus cider intake 0.8 1.2 2.5 1.0 -1.6 -0.4
Irritability 0.7 1.2 3.0 -0.1 -0.8 -1.7
Risk taking 2.4 3.6 7.1 1.9 -2.7 0.0
Ever had prostate specific antigen (PSA) test 2.1 2.4 4.6 -2.1 1.5 -0.6
Fractured/broken bones in last 5 years 0.3 0.4 0.6 0.0 -0.7 -0.8
Age started oral contraceptive pill 1.2 1.5 1.9 -1.4 1.3 0.9
Diastolic blood pressure, automated reading 0.0 0.1 0.3 -0.5 0.1 -0.2
Ever depressed for a whole week 1.3 1.6 3.9 0.2 -2.0 -0.9
Unable to work because of sickness or disability 5.1 6.6 12.1 3.5 -2.8 -0.0
Commuting to job workplace: Cycle 0.5 0.6 1.5 -0.5 0.3 -1.2
Myopia 0.1 0.1 0.3 -0.5 0.2 0.1
Vascular/heart problems diagnosed by doctor 0.3 0.9 1.5 -1.1 1.2 0.1
Cholesterol lowering medication 0.4 0.6 1.2 0.8 0.3 1.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.0 0.3 0.2 1.0
Pain experienced in last month 1.7 2.8 5.6 -1.6 2.4 0.4
Supplements: Calcium 1.2 1.3 2.0 1.1 -1.4 0.8
Basal cell carcinoma (self-reported) 0.3 0.3 0.4 -0.6 0.5 -0.6
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.5 1.2 -0.3 0.5
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.5 0.4 -0.7 0.6
Heart disease (siblings) 3.3 4.1 7.3 2.2 -2.7 -0.4
Alcohol drinker status: Previous 1.1 1.3 3.1 1.8 -0.8 -0.4
Pack years of smoking 1.8 2.6 7.3 -0.7 -0.1 -2.7
Impedance of whole body 0.1 0.5 0.7 -0.8 0.8 -0.4
Leg fat mass (left) 0.1 0.4 0.5 0.6 -0.4 -0.7
Arm predicted mass (left) 0.3 1.5 4.1 -0.6 -0.3 -2.0