Hub : Genes

NFATC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.3180	0.1120	4.6e-03	0.028	NA	0.010	NA	0.010	5.5e-02	NA	1.7e-01	NA	1.7e-01
2	GTEx	Brain Frontal Cortex BA9	0.4220	0.1003	2.1e-04	-0.008	NA	0.027	NA	0.086	6.2e-01	NA	6.5e-02	NA	2.7e-03
3	GTEx	Muscle Skeletal	0.1232	0.0519	7.3e-03	0.079	NA	0.052	NA	0.073	3.7e-08	NA	8.1e-06	NA	1.1e-07
4	METSIM	Adipose	0.1231	0.0321	1.3e-06	0.067	0.053	0.064	0.059	0.074	2.8e-10	2.1e-08	6.2e-10	3.3e-09	3.5e-11
5	YFS	Blood	0.1734	0.0308	0.0e+00	0.085	0.103	0.142	0.149	0.143	2.8e-26	6.8e-32	2.9e-44	3.1e-46	2.5e-44
6	TCGA	Lung Adenocarcinoma	0.0437	0.0219	9.7e-03	-0.002	0.013	0.004	NA	0.002	5.7e-01	1.0e-02	1.1e-01	NA	1.5e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	2.9	-0.1	1.7	0.0	0.0	0.1	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.7	3.8	0.1	1.9	0.0	0.0	0.0	-0.7
Depressed Affect (Nagel 2018)	0.2	0.3	1.1	0.7	-0.0	-0.2	-1.1	-0.3	0.5
Depression (Nagel 2018)	0.4	0.6	2.4	-0.6	-0.3	-0.2	-1.6	-0.8	-0.1
Intelligence (Savage-Jansen 2018)	1.0	3.1	13.2	0.8	-0.2	1.2	-1.6	-0.6	-3.6
Neuroticism (Nagel 2018)	0.2	0.4	1.0	0.5	0.3	-0.9	-0.6	-0.2	1.0
Schizophrenia (2018)	0.1	0.3	1.3	0.1	1.1	0.0	0.0	0.1	-0.6
Schizophrenia vs Biploar Disorder	0.5	0.7	4.2	-2.0	-0.0	0.0	0.0	-0.3	0.2
Worry (Nagel 2018)	0.5	1.0	3.5	-0.2	0.1	-1.9	-0.7	-0.9	1.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.7	0.8	0.1	0.8	0.3	0.3	-0.6
Alzheimer’s Disease (in father)	0.6	0.6	1.5	-0.6	-0.2	-0.6	-1.2	-0.2	1.2
Alzheimer’s Disease (including proxy)	0.1	0.1	0.4	0.0	-0.1	-0.3	0.1	0.1	0.7
Crohns Disease (2017)	1.8	3.9	7.9	0.4	2.3	-1.0	-1.9	-2.8	-2.4
Irritable Bowel Disease (IBD)	3.1	7.4	14.0	0.5	3.7	-1.4	-3.2	-3.6	-2.1
Ulcerative Colitis (UC)	2.6	5.0	10.8	0.2	2.8	-1.5	-3.3	-3.0	-0.5
Major Depression (MDD)	0.1	0.1	0.6	0.6	0.0	0.0	0.0	-0.7	0.0
Reaction Time	0.5	1.0	2.7	1.6	0.2	-0.5	0.7	1.2	1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	6.2	-0.3	-0.4	2.1	-0.5	0.5	-2.5
Breast Cancer	0.2	0.4	0.9	-0.7	0.2	-0.7	-1.0	-0.8	0.2
Ovarian Cancer	0.4	0.5	1.8	-1.3	0.4	0.5	-0.9	0.3	-0.1
Prostate Cancer	1.2	1.7	6.3	-2.5	-0.9	-1.0	0.2	-0.5	1.3
Age at First Birth	1.5	2.2	6.2	1.1	1.4	-2.5	-0.1	-1.9	-0.5
Bipolar Disorder (2011)	0.0	0.0	0.2	0.5	0.0	0.0	0.0	0.3	0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	-0.7	0.2	0.0	1.2	-0.0	0.8
Coronary Artery Disease (CAD)	1.5	1.8	6.6	-1.9	-2.6	0.0	0.0	0.1	0.4
Crohns Disease (2012)	1.0	1.5	3.6	0.6	1.3	0.0	0.0	-1.9	-1.9
Mean Putamen Volume	1.3	1.5	2.5	1.6	1.2	-0.8	-1.5	-0.6	-1.3
Fasting Glucose	0.8	1.0	3.3	-0.5	0.2	-1.8	-0.3	-1.3	-0.8
HbA1C	2.6	2.9	6.5	-0.7	2.5	-0.7	-2.1	-1.8	-1.5
HDL Cholesterol	0.3	0.4	1.4	-1.2	0.8	0.0	0.1	0.1	0.8
LDL Cholesterol	0.3	0.5	1.4	0.4	0.3	0.0	1.2	0.9	0.5
Lupus	2.3	3.4	9.2	-1.3	-3.0	-2.4	1.3	0.6	1.3
Neuroticism (2016)	0.2	0.3	1.0	0.5	-1.0	0.1	-0.5	0.2	0.7
Primary Biliary Cirrhosis	0.3	0.4	1.6	-0.2	-0.2	-1.3	0.7	-0.3	-0.4
Rheumatoid Arthritis	1.4	1.9	7.7	0.1	-1.8	0.0	0.0	0.7	2.8
Schizophrenia (2014)	0.1	0.3	1.2	-1.1	0.7	0.0	0.0	0.2	-0.4
Triglycerides	0.0	0.0	0.1	0.3	0.1	0.0	0.0	-0.3	0.0
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.4	-0.8	-1.8	0.0	0.0	1.1	1.6
Ulcerative Colitis	1.0	1.5	5.5	-0.5	1.3	0.0	0.0	-2.3	-1.1
Blood Eosinophil Count	0.7	5.4	12.5	1.1	-2.5	-0.7	3.5	2.4	2.5
Blood Platelet Count	0.2	2.6	8.9	0.4	0.5	-0.7	2.1	3.0	1.2
Blood Red Count	0.8	8.0	21.7	-0.4	-2.3	4.7	1.4	3.9	1.9
Blood White Count	0.7	4.9	8.4	-1.9	-2.5	1.2	2.4	2.9	1.9
Heel T-Score	5.7	45.7	102.0	-2.2	-6.6	6.7	7.2	10.1	5.2
BMI	0.9	5.1	10.4	-0.1	-1.6	1.9	3.2	3.2	2.0
Height	2.5	49.1	161.3	-0.2	3.6	-3.8	-12.7	-9.3	-4.3
Waist Hip Ratio (WHR)	1.9	8.5	25.5	1.3	2.5	-1.1	-5.0	-3.5	-2.0
Systolic Blood Pressure	0.3	1.3	4.3	-0.7	-0.2	0.8	1.5	2.1	-0.1
Smoking Status	0.6	1.4	3.2	-0.5	-1.7	0.3	1.8	1.4	-0.3
Allergy or Eczema	0.5	1.4	5.3	-2.3	-1.5	0.2	0.0	-0.2	-0.8
Cardiovascular Disease	0.3	0.9	1.9	-0.9	-1.4	0.3	1.0	1.4	-0.3
Hypothyroidism (self reported)	4.8	11.1	43.3	-0.9	-2.7	-2.0	2.4	2.3	6.6
Respiratory disease	1.1	2.4	9.2	-1.4	-3.0	0.8	-1.0	0.4	1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.8	-1.0	-0.9	1.2	0.8	0.9	1.3
Lung FEV1/FVC ratio	0.9	4.5	8.2	-2.0	-1.8	0.2	2.9	2.8	1.8
Lung FVC	0.9	4.5	15.7	-0.5	-0.8	-4.0	2.7	-1.7	0.1
Neuroticism	0.2	0.4	1.5	1.2	-0.3	-0.8	-0.3	-0.3	0.3
Chronotype (morning person)	0.8	2.0	5.3	0.6	2.3	-1.9	0.2	-1.5	0.3
Hair Pigment	0.1	2.5	6.2	-2.5	-2.2	-0.2	1.4	0.7	1.0
Tanning	0.4	5.3	14.1	1.2	1.2	-3.8	-1.7	-3.3	-0.9
Hand grip strength (left)	0.8	2.0	3.1	1.8	-0.7	1.5	1.6	1.5	-1.1
Number of treatments/medications taken	1.1	1.9	5.9	0.1	-1.2	-1.5	1.3	0.3	2.4
Average weekly spirits intake	0.7	0.9	3.3	0.9	1.8	0.9	-0.4	0.2	0.4
Sensitivity / hurt feelings	0.6	1.1	3.5	1.9	1.3	-0.7	0.7	-0.3	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.7	0.6	0.0	-0.5	-1.7	-0.9	0.0
Hearing difficulty/problems: Yes	0.8	1.2	3.5	0.2	-1.9	-0.9	-0.0	0.1	1.7
Relative age of first facial hair	1.1	2.2	6.2	1.1	-2.5	0.2	1.9	1.3	-0.4
Other serious medical condition/disability diagnosed by doctor	3.5	4.6	8.9	-1.3	-2.5	-3.0	1.6	-0.3	2.9
Ever used hormone-replacement therapy (HRT)	0.7	0.8	2.2	-1.2	-1.5	0.6	0.4	0.5	0.8
Ever had hysterectomy (womb removed)	0.7	0.8	2.0	-0.5	-0.6	-0.7	1.4	-0.2	1.3
Systolic blood pressure, automated reading	0.3	0.9	1.9	-0.8	-0.3	1.4	0.5	1.2	-0.9
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.7	1.1	0.1	1.3	1.2	0.9	-0.2
Angina	0.7	0.9	2.4	0.1	-1.1	-0.8	1.0	0.1	1.6
Medication for hormone replacement therapy	0.6	0.7	2.1	1.4	0.0	-1.1	0.9	-0.3	-0.1
Vitamin and mineral supplements	2.4	3.3	6.3	1.6	1.9	-0.0	-2.5	-2.1	-1.7
Supplements: Zinc	1.3	1.4	3.4	-1.3	-0.3	1.0	1.8	1.5	0.2
Medication: Co-codamol	0.3	0.3	0.7	-0.6	0.2	-0.8	-0.0	-0.7	-0.5
Medication: Metformin	0.6	0.8	1.7	0.4	-0.7	1.2	1.3	1.1	0.3
Diabetes (father)	1.1	1.4	2.5	1.6	0.8	-1.2	-0.9	-1.3	-1.1
Diabetes (mother)	1.5	1.9	5.0	0.3	-1.0	2.2	1.1	1.9	0.7
Severe depression (siblings)	1.4	1.6	3.7	1.8	0.7	-1.9	1.0	-0.7	0.5
Pack years adult smoking proportion	0.7	1.1	2.4	-1.3	0.1	0.9	1.0	0.7	1.5
Impedance of leg (right)	1.1	5.2	19.1	0.1	1.6	-2.1	-4.4	-2.2	-0.7
Leg fat-free mass (left)	0.1	0.3	0.5	-0.4	-0.7	0.7	-0.7	-0.0	0.6
Trunk fat percentage	0.9	3.6	10.6	-0.3	-2.0	3.3	-0.1	2.6	0.7
Hand grip strength (right)	0.9	2.4	5.4	2.0	-1.4	0.7	2.3	1.4	-0.8
Townsend deprivation index at recruitment	0.2	0.2	0.5	-0.0	-0.5	0.7	-0.6	-0.4	0.5
Current tobacco smoking	0.1	0.2	0.4	-0.0	-0.4	0.6	-0.3	0.5	-0.6
Average weekly fortified wine intake	0.4	0.4	2.2	-0.2	1.5	-0.6	-0.1	0.0	0.0
Maternal smoking around birth	0.4	0.5	1.3	0.5	-0.7	-0.4	1.1	0.4	1.0
Fed-up feelings	0.4	0.7	2.2	0.1	-1.5	-0.2	-0.3	-0.0	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.1	-0.2	0.0	0.6	0.8	0.7
Relative age voice broke	1.2	1.9	3.9	-0.8	-1.9	-0.1	2.0	1.5	0.9
Taking other prescription medications	1.5	2.2	4.3	-1.2	-2.1	-1.9	-0.3	-1.0	1.8
Age when periods started (menarche)	0.3	0.7	2.0	-1.4	-0.3	0.6	-0.5	0.5	1.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.3	0.5	-1.5	-0.9	0.5	-0.7	0.7
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	9.4	0.2	-3.0	2.7	1.6	3.1	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	-0.9	-0.1	-0.8	-0.7	-0.0	0.8
Qualifications: CSEs or equivalent	1.0	1.3	3.3	1.3	-1.0	0.5	1.8	1.3	0.1
Serious illness, injury or assault to yourself	0.6	0.7	1.8	-0.5	-0.6	-1.3	1.3	-0.2	0.1
High blood pressure	1.6	4.6	11.5	-2.2	-3.4	-0.1	2.3	2.1	1.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.4	-1.5	-1.6	-0.3	-0.9	-0.6	-0.7
Multivitamins +/- minerals	2.0	2.5	6.3	-0.3	-2.0	-0.0	2.5	1.8	1.3
Stomach or abdominal pain in last month	0.4	0.5	2.0	0.8	-0.3	-0.3	-0.4	-0.0	-1.4
Supplements: Glucosamine	0.3	0.4	1.0	0.9	0.1	-0.1	-1.0	-0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.7	-0.7	0.4	-0.7	-0.1	-0.5	-1.9
Medication: Atenolol	0.1	0.2	0.5	-0.4	-0.4	-0.5	0.7	-0.1	0.2
Medication: Levothyroxine sodium	3.6	6.2	18.4	-1.7	-2.7	-2.5	1.2	0.9	4.3
Sitting height	0.0	0.2	0.9	-0.3	-0.4	0.1	-1.0	0.1	0.6
Chronic bronchitis/emphysema (father)	1.2	1.4	4.2	2.1	0.7	-0.9	-0.8	-0.5	-1.5
High blood pressure (mother)	0.5	0.7	1.7	0.7	-1.3	0.1	-1.0	-0.2	-0.8
Body mass index (BMI)	1.5	6.4	11.3	-0.5	-2.8	1.9	3.1	3.4	2.4
Impedance of leg (left)	0.9	4.3	15.0	0.7	2.0	-1.4	-3.9	-1.8	-1.1
Leg predicted mass (left)	0.1	0.4	0.6	-0.4	-0.7	0.8	-0.8	0.0	0.7
Trunk fat mass	0.6	2.4	6.0	-0.5	-1.9	2.4	-0.4	1.9	1.0
Waist circumference	0.1	0.5	0.9	0.5	-0.8	0.7	-1.0	0.4	0.8
Number of incorrect matches in round	0.5	0.8	2.6	-1.6	-0.7	-0.6	0.2	-0.4	1.1
Past tobacco smoking	0.9	1.7	3.4	0.6	1.8	-1.0	-1.5	-1.6	-0.6
Alcohol usually taken with meals	0.5	0.8	1.8	-0.5	0.3	-1.3	-1.2	-1.0	-0.7
Nervous feelings	0.3	0.5	1.8	0.2	-0.0	-1.4	0.4	-0.3	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	3.0	-0.9	-0.7	-0.9	0.5	0.9	1.7
Hearing difficulty/problems with background noise	1.9	3.1	8.3	2.3	0.2	-2.9	-1.4	-1.8	0.2
Hair/balding pattern: Pattern 2	0.6	0.8	3.0	1.7	0.5	0.5	0.1	0.8	-0.8
Had menopause	0.7	0.9	1.8	-1.2	1.3	-1.0	-0.8	-0.7	0.0
Had other major operations	2.1	2.5	6.4	-2.5	-1.8	-1.2	1.6	0.1	1.3
Forced vital capacity (FVC)	1.3	5.2	17.6	-0.6	0.0	-4.2	-1.7	-3.1	0.5
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.8	14.4	-0.3	-3.8	2.1	1.8	3.3	1.5
Ever unenthusiastic/disinterested for a whole week	2.1	2.5	10.2	-0.2	-0.8	0.8	3.2	1.6	1.1
Qualifications: None of the above	0.4	0.9	1.9	-0.8	-1.4	-0.2	-1.1	0.3	1.1
Financial difficulties in last 2 years	0.8	1.1	2.4	0.6	-1.5	-0.2	1.5	0.6	1.1
Mouth/teeth dental problems	0.2	0.3	0.9	-1.0	0.8	0.5	0.1	-0.2	0.3
Heart attack	1.3	1.6	3.8	-0.3	-2.0	-0.6	1.9	0.9	1.2
Allergy	0.6	1.3	2.6	0.9	1.1	0.1	1.5	1.0	1.6
Pain all over the body in last month	1.3	1.4	3.9	0.1	-0.6	-2.0	1.9	-0.1	0.8
Diabetes (self-reported)	1.3	2.0	3.9	0.2	-1.4	1.1	2.0	1.9	1.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.6	0.3	-0.9	1.6	-1.0	0.7	-1.4
Medication: Ramipril	1.3	1.7	5.8	0.4	0.1	0.6	2.4	1.6	1.1
Medication: Simvastatin	0.5	0.7	2.0	0.0	0.4	-0.0	1.3	0.6	1.4
Fluid intelligence score	0.7	1.5	4.2	-0.1	-1.5	1.4	-0.7	0.5	-2.1
Illnesses of siblings	1.5	2.0	5.3	1.6	2.3	-0.2	-1.1	-0.9	-1.5
Neuroticism score	0.2	0.4	1.1	0.4	-0.5	-0.9	0.2	-0.4	1.1
Weight	0.2	1.1	2.9	-0.7	-1.7	0.5	-0.5	0.7	1.4
Impedance of arm (right)	1.3	6.1	13.0	0.9	1.3	3.2	-3.3	-0.3	-3.6
Arm fat percentage (right)	2.2	8.6	19.4	-0.2	-2.7	4.4	2.3	4.3	1.2
Trunk fat-free mass	0.4	2.5	5.2	-0.7	0.2	-2.1	-2.3	-2.2	0.7
Hip circumference	0.2	0.8	1.7	0.1	-0.9	1.0	-0.4	1.1	1.3
Time employed in main current job	1.3	1.5	7.8	0.2	0.6	-0.3	2.8	0.9	0.4
Alcohol intake versus 10 years previously	0.4	0.6	2.4	0.8	-0.0	-0.2	1.5	0.5	0.1
Father’s age at death	2.4	3.3	5.7	2.4	2.3	-0.6	-1.4	-2.0	-1.5
Worrier / anxious feelings	0.2	0.3	1.6	0.1	0.3	-0.3	-0.5	-0.2	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	6.2	-1.4	-2.5	-0.7	-0.6	0.3	1.4
Falls in the last year	0.6	0.8	2.0	1.4	0.8	-0.3	0.2	-0.3	-1.4
Hair/balding pattern: Pattern 3	1.9	2.9	9.5	-3.1	0.2	-1.8	-1.3	-1.7	0.2
Number of live births	0.2	0.3	0.8	0.0	-0.9	-0.5	0.2	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.0	12.0	-0.8	-1.3	-3.5	-0.1	-1.3	1.4
Pulse rate	2.2	3.8	12.6	0.2	1.4	3.6	1.5	2.0	-1.2
Happiness	0.7	0.9	3.3	0.2	1.8	0.8	0.3	1.1	0.3
Noisy workplace	0.3	0.4	1.3	-0.5	-1.1	-0.5	0.0	-0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.6	0.7	1.9	-0.1	-0.7	-0.5	-1.6
Serious illness, injury or assault of a close relative in last 2 years	1.8	2.1	4.6	-2.2	-1.8	0.4	0.9	0.0	1.9
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.4	-0.1	-0.4	0.3	0.2	-0.7
Asthma	0.5	1.0	2.3	-1.1	-1.5	1.0	-1.0	-0.1	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	4.6	2.2	0.5	-0.6	-0.3	-0.4	-0.6
Medication: Cholesterol lowering	0.4	0.6	0.9	-0.7	-0.8	-0.7	0.9	-0.7	0.6
Depression (self-reported)	0.9	1.0	2.2	1.5	1.4	-1.3	0.3	-0.4	-0.2
Medication: Lansoprazole	1.7	2.0	4.7	-2.2	-1.2	-1.3	-0.5	-0.1	1.9
Prospective memory result	0.6	0.7	1.7	-1.2	1.3	0.4	-0.1	-0.3	0.8
Lung cancer (father)	0.3	0.3	1.0	-1.0	1.0	-0.0	-0.1	-0.2	0.1
Illnesses of mother	0.1	0.2	0.6	0.3	0.8	0.3	-0.0	0.5	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	12.9	-0.3	-0.5	-3.6	-0.3	-1.8	1.3
Pulse wave Arterial Stiffness index	2.0	2.4	5.5	-0.9	-0.7	1.2	1.6	1.8	2.4
Impedance of arm (left)	1.1	5.2	13.8	0.5	0.8	2.2	-3.7	-0.9	-3.3
Arm fat mass (right)	1.0	4.3	8.9	-0.4	-2.2	3.0	1.4	2.9	1.2
Trunk predicted mass	0.5	2.6	5.2	-0.6	0.2	-2.1	-2.3	-2.2	0.7
Standing height	2.0	20.0	63.8	-0.3	2.4	-3.1	-8.0	-5.9	-2.4
Length of working week for main job	1.8	2.0	3.7	0.9	-1.3	1.9	1.4	1.9	0.7
Exposure to tobacco smoke at home	1.2	1.3	2.3	0.0	1.0	1.2	1.4	1.5	-1.1
Breastfed as a baby	0.6	0.8	1.7	-1.3	-0.7	0.7	0.9	0.4	1.1
Tense / ‘highly strung’	0.4	0.7	1.3	-1.1	-0.0	-0.6	-1.2	-1.0	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.7	0.4	-0.7	-0.0	0.2	-0.1	0.8
Hair/balding pattern: Pattern 4	0.4	0.9	1.8	-0.8	1.3	-0.3	-1.2	-0.8	-1.1
Birth weight of first child	0.3	0.6	1.7	-1.3	0.1	-0.4	-0.4	-1.0	0.7
Peak expiratory flow (PEF)	1.6	3.7	17.2	-0.1	-4.1	-1.0	1.2	0.9	1.3
Pulse wave reflection index	1.5	1.8	6.9	0.5	-2.6	-1.0	0.3	0.0	1.6
Ever highly irritable/argumentative for 2 days	3.3	3.9	8.2	-0.0	-2.3	-0.0	2.9	2.2	2.3
Loud music exposure frequency	0.4	0.5	0.8	0.7	-0.2	0.8	0.4	0.9	0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.2	-0.8	0.8	2.3	0.5	1.5	-0.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	3.5	0.3	-1.9	0.7	0.5	0.9	1.0
Blood clot in the leg (DVT)	1.8	2.3	6.0	-0.2	0.1	-1.5	-2.3	-2.5	-0.7
Medication: Paracetamol	0.4	0.6	1.6	-0.0	-0.5	-0.5	-1.3	-0.6	1.1
Headache pain in last month	0.1	0.1	0.2	0.2	0.1	-0.5	0.5	-0.0	0.3
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.5	1.2	1.0	-0.3	-2.1	-1.0	-1.3
Glaucoma (self-reported)	0.3	0.4	1.3	1.1	0.0	-0.4	0.5	0.4	-0.6
Gout (self-reported)	0.1	0.2	0.7	0.0	0.8	0.1	0.5	-0.3	0.0
Hypothyroidism/myxoedema (self-reported)	2.6	5.0	19.0	-0.8	-1.7	-2.1	1.1	1.4	4.4
Medication: Amlodipine	0.6	0.9	3.4	-1.8	-0.9	0.2	0.9	0.4	0.2
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.3	0.2	-1.5	-0.0	-1.4	-0.8	-1.4
Birth weight	0.3	0.7	1.6	-1.3	0.5	0.9	0.7	0.9	0.0
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.6	0.2	0.8	0.2	0.8	0.1	0.0
High blood pressure (siblings)	1.5	2.2	5.7	-0.5	-2.4	1.0	1.4	1.6	1.3
Forced vital capacity (FVC), Best measure	1.6	5.7	19.0	0.1	0.8	-4.4	-1.5	-3.5	0.3
Body fat percentage	1.2	4.6	9.4	-0.6	-2.3	3.0	0.8	3.1	1.6
Leg fat percentage (right)	1.4	5.2	10.0	-1.6	-2.7	1.3	1.4	2.8	3.2
Arm fat-free mass (right)	0.4	1.9	4.6	-0.7	-0.3	-2.1	-1.5	-1.5	1.3
Exposure to tobacco smoke outside home	2.0	2.7	7.4	-1.8	-2.7	-0.9	0.8	0.9	1.9
Comparative body size at age 10	4.1	11.2	27.7	1.2	0.8	5.3	3.6	4.9	0.9
Number of full brothers	1.1	1.4	5.0	-0.6	-1.5	-0.5	0.9	0.1	2.2
Worry too long after embarrassment	0.5	0.9	2.4	1.6	-0.8	-1.4	0.3	-0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.6	-0.8	-1.2	0.1	1.1	1.3	1.3
Wheeze or whistling in the chest in last year	0.4	0.7	2.1	-0.0	-1.5	0.7	-1.1	-0.4	0.4
Number of children fathered	0.7	0.7	1.5	0.0	-1.2	1.1	-0.3	0.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.4	0.8	-0.5	-0.1	-0.3	0.3
Age at first live birth	0.3	0.5	1.8	0.8	1.3	-0.3	-0.6	-0.1	0.2
Pulse wave peak to peak time	2.7	3.2	6.0	0.8	0.5	-1.4	-2.2	-2.3	-2.5
Health satisfaction	0.3	0.4	1.6	-1.3	0.1	-0.6	-0.3	-0.2	0.7
Shortness of breath walking on level ground	0.9	1.0	3.7	1.1	1.9	-0.8	-0.2	-0.5	-0.8
Qualifications: College or University degree	0.6	2.0	5.6	0.4	0.7	-1.1	-1.9	-2.4	-1.1
Eye problems/disorders: None of the above	1.0	1.1	2.6	-1.6	-1.6	0.4	0.3	0.8	1.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.7	-1.3	-1.0	-0.5	0.5	0.1	0.5
Emphysema/chronic bronchitis	1.3	1.5	3.5	0.4	-0.9	1.8	-0.1	1.9	1.2
Medication for pain relief, constipation, heartburn	0.8	1.3	3.8	-1.2	0.2	1.9	0.4	1.5	-0.2
Neck or shoulder pain in last month	1.8	2.5	7.4	2.7	-2.2	-0.9	1.0	0.3	0.9
Medication: Blood pressure	1.8	3.2	10.4	-0.8	-1.2	0.5	3.2	2.2	1.2
Angina (self-reported)	0.8	1.1	3.0	-0.0	-1.3	-0.9	1.0	0.1	1.7
Migraine (self-reported)	1.5	1.9	6.2	1.3	1.1	1.4	-0.3	0.0	-2.5
Medication: Ibuprofen	1.2	1.4	7.8	2.8	0.2	-0.4	0.6	0.2	-0.2
Medication: Allopurinol	0.2	0.3	1.0	-0.4	0.3	-0.6	-0.0	-1.0	0.1
Medication: Omeprazole	1.5	1.8	3.1	-0.9	-1.3	-1.6	-1.8	-1.6	0.0
Medication: Seretide 50 evohaler	1.8	2.1	7.9	-0.5	-1.1	2.8	-0.1	1.7	0.4
Mean time to correctly identify matches	0.4	0.7	1.3	0.8	-0.1	-0.4	1.0	1.1	1.1
Heart disease (mother)	1.8	2.2	5.3	-2.3	-1.4	-1.3	-0.3	-0.9	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.7	3.2	-0.5	-1.8	0.7	1.8	1.4	1.0
Whole body fat mass	0.7	2.8	5.2	-0.8	-1.9	2.3	0.2	2.2	1.6
Leg fat mass (right)	0.8	3.2	5.9	-1.2	-2.4	1.1	0.8	2.1	2.3
Arm predicted mass (right)	0.4	2.2	5.3	-0.8	-0.3	-2.3	-1.5	-1.6	1.6
Pulse rate, automated reading	1.5	4.7	19.0	1.2	0.6	4.4	0.1	1.6	-2.2
Alcohol intake frequency.	0.6	1.4	4.1	0.2	0.5	1.0	2.0	1.7	-0.2
Comparative height size at age 10	1.0	5.4	14.7	-0.0	0.1	-3.1	-3.8	-2.9	0.3
Number of full sisters	0.2	0.3	0.5	-0.5	-0.5	-0.4	0.7	0.1	0.7
Suffer from ‘nerves’	0.6	1.0	3.2	-0.1	-0.4	-1.8	1.4	-0.3	0.5
Overall health rating	0.8	1.7	4.4	-1.1	-1.5	-1.4	0.0	-0.4	2.1
Chest pain or discomfort	1.5	2.1	7.1	0.2	-2.7	-0.7	2.1	0.5	0.7
Had major operations	0.4	0.5	2.1	-1.4	-0.2	0.5	-0.8	-0.1	-0.0
Age at last live birth	1.2	1.7	4.7	1.9	2.2	0.2	-0.4	-0.6	-1.1
Family relationship satisfaction	2.8	3.5	9.1	-0.0	0.5	2.0	2.7	3.0	0.4
Leg pain on walking	0.6	0.7	1.7	-0.8	-0.7	-1.3	-0.6	-0.1	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.1	-0.7	-0.4	1.1	-0.0	0.6	-0.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.7	-1.1	-1.2	0.1	0.5	1.3	0.8
Illness, injury, bereavement, stress in last 2 years	3.0	3.7	10.3	1.2	2.8	0.7	-1.3	-0.7	-3.2
Medication: Aspirin	1.0	1.3	3.5	0.8	0.4	-1.6	1.9	-0.8	0.6
Supplements: Vitamin C	2.0	2.4	4.7	-1.6	-1.0	-0.2	2.0	2.2	1.4
Knee pain experienced in last month	0.5	0.8	2.8	-0.5	-1.1	-1.7	-0.5	-0.4	0.6
Hypertension (Self-reported)	1.3	3.6	10.2	-1.9	-3.2	-0.3	1.8	1.9	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	1.9	6.8	-2.6	-1.0	-1.5	-0.1	-0.8	0.9
Illnesses of father: Heart disease	0.2	0.3	0.6	0.1	-0.2	-0.3	-0.7	-0.8	-0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.8	-0.3	0.4	0.5	0.1	0.0	0.9
Smoking status: Previous	1.1	1.7	3.6	-0.4	-1.6	0.9	1.9	1.5	1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	13.0	-0.3	0.3	-1.8	-3.6	-2.6	0.6
Whole body fat-free mass	0.2	1.0	2.5	-0.6	-0.1	-1.1	-1.6	-1.3	0.7
Leg fat-free mass (right)	0.0	0.2	0.7	-0.0	-0.3	0.8	-0.6	-0.1	0.2
Arm fat percentage (left)	1.9	7.5	15.8	-0.6	-2.8	4.0	2.0	3.9	1.4
Average weekly red wine intake	0.7	1.1	3.2	-0.1	0.3	0.5	-1.3	-1.1	-1.8
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.9	0.1	0.9	1.7	0.5	0.8	-0.1
Mood swings	0.1	0.3	1.3	0.0	0.3	0.2	-0.3	0.2	1.1
Loneliness, isolation	1.0	1.4	5.9	-0.5	-0.2	-1.0	1.2	0.2	2.4
Long-standing illness, disability or infirmity	1.2	1.9	3.8	-1.0	-1.9	-1.6	0.1	-0.6	2.0
Ever had bowel cancer screening	1.9	2.2	5.0	-1.4	-1.1	-2.2	0.8	-0.4	2.1
Diabetes diagnosed by doctor	1.4	2.2	5.8	0.2	-1.3	0.9	2.4	1.7	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	4.3	2.1	-0.6	1.0	0.4	1.1	-0.7
Friendships satisfaction	0.8	1.0	2.7	-0.5	1.1	0.8	1.0	1.6	0.8
Qualifications: nursing, teaching	0.5	0.8	2.4	-0.6	0.9	-1.6	-0.4	-1.1	0.2
Commuting to job workplace: Walk	0.9	1.0	2.8	-0.2	0.6	1.2	1.7	0.8	-0.6
Eye problems/disorders: Cataract	0.7	0.8	3.7	-0.1	1.9	0.2	-0.4	-0.6	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.9	1.7	0.8	-1.0	-1.1	-1.4	-0.5
Medication for cholesterol	1.2	1.8	5.6	0.7	1.2	2.4	-0.7	-0.3	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.8	4.5	8.0	-2.7	-2.8	-1.8	-0.6	-0.9	2.7
Back pain experienced in last month	1.0	1.5	3.2	-0.1	-1.8	-1.6	-0.7	-1.5	0.6
Mineral and other dietary supplements	1.4	1.9	3.9	1.9	0.8	0.1	-2.0	-1.4	-1.1
Breast cancer (self-reported)	0.8	1.0	3.3	-1.8	-0.8	0.5	0.6	0.5	1.1
Asthma (self-reported)	0.6	1.3	2.7	-1.1	-1.7	0.9	-1.4	-0.2	-0.9
Osteoporosis (self-reported)	1.9	2.3	5.5	-0.3	1.8	-0.3	-2.3	-2.0	-1.1
Osteoarthritis (self-reported)	2.1	2.7	6.4	-1.2	-0.3	-2.5	-1.8	-2.0	1.1
Medication: Aspirin	1.0	1.2	4.1	0.7	0.3	-1.4	2.0	-0.6	0.5
Medication: Gliclazide	0.3	0.4	0.7	0.6	0.3	-0.5	0.8	0.4	-0.8
Illnesses of father: None of the above (group 1)	0.5	0.7	2.1	-1.1	-1.4	-0.1	0.8	0.1	0.0
Smoking status: Current	0.2	0.2	0.5	0.1	-0.5	0.6	0.0	0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	14.7	-0.3	-1.4	-3.8	1.4	-1.1	0.7
Whole body water mass	0.2	0.9	2.2	-0.6	-0.3	-1.0	-1.5	-1.2	0.8
Leg predicted mass (right)	0.0	0.2	0.8	0.1	-0.3	0.9	-0.6	-0.0	0.2
Arm fat mass (left)	0.9	3.6	6.8	-0.5	-2.1	2.6	1.2	2.6	1.4
Number of self-reported non-cancer illnesses	1.3	2.3	7.5	-0.8	-1.1	-2.7	-0.9	-1.9	-0.1
Average weekly champagne plus white wine intake	1.7	2.3	6.6	0.3	1.3	-2.6	-1.1	-1.8	0.9
Miserableness	0.1	0.1	0.3	0.4	-0.4	-0.0	-0.6	0.0	0.4
Guilty feelings	0.1	0.2	1.0	1.0	0.0	-0.1	-0.3	0.1	0.1
Wears glasses or contact lenses	0.9	1.1	2.2	-1.2	-0.8	-0.2	-1.5	-1.3	-0.7
Ever taken oral contraceptive pill	1.0	1.1	2.4	0.6	1.2	0.6	1.4	1.5	-0.1
Hearing aid user	0.4	0.5	1.4	0.7	0.4	0.7	-0.4	0.5	-1.2
Mother’s age at death	0.6	0.7	1.8	-0.2	-0.2	-1.1	-0.2	-1.3	-1.0
Financial situation satisfaction	0.4	0.5	1.2	-0.1	1.0	1.1	0.6	0.7	0.0
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.3	-0.1	-0.0	0.2	0.6	0.2	-0.5
Commuting to job workplace: Public transport	0.5	0.6	1.7	-0.4	0.3	-1.3	-0.4	-1.1	0.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	0.6	0.5	-0.1	0.7	0.7	-0.8
Medication: Blood pressure	1.6	3.0	6.4	-1.7	-2.5	-1.7	0.7	0.6	2.2
Pain type(s) experienced in last month: Hip pain	1.8	2.3	5.0	-1.5	-0.9	-2.2	-0.5	-1.9	1.3
Supplements: Fish oil (including cod liver oil)	3.1	4.1	6.7	-2.2	-2.6	0.7	2.0	2.3	1.9
High cholesterol (Self-reported)	0.1	0.3	0.7	0.2	-0.4	-0.9	0.1	-0.1	0.8
Medication: Bendroflumethiazide	2.7	4.1	10.0	-3.2	-1.9	-0.5	1.0	1.9	2.4
Medication: Paracetamol	0.3	0.4	1.1	0.7	-0.0	-0.4	-1.0	-0.1	0.9
Medication: Lisinopril	1.2	1.5	5.3	-0.7	-0.6	1.2	1.0	2.3	0.7
Medication: Atorvastatin	1.4	1.7	5.2	-2.3	-1.4	-1.1	-0.1	-0.9	1.1
Illnesses of father: High blood pressure	0.2	0.2	0.9	-0.1	-0.1	0.7	-0.1	0.4	1.0
Alcohol drinker status: Never	1.6	1.9	4.5	1.5	0.2	-2.1	0.2	-1.1	-1.8
Ever smoked	0.7	1.3	3.3	-0.9	-1.2	1.3	0.6	1.8	0.6
Basal metabolic rate	0.1	0.6	1.5	-0.5	-0.6	-0.5	-1.2	-0.6	0.9
Leg fat percentage (left)	1.4	5.2	9.8	-1.0	-2.4	1.7	1.8	3.1	2.9
Arm fat-free mass (left)	0.3	1.4	3.1	-0.5	-0.5	-1.8	-1.2	-1.1	1.5
Number of operations (self-reported)	0.4	0.6	1.5	-1.2	-1.1	0.2	0.4	-0.2	0.7
Average weekly beer plus cider intake	0.8	1.1	2.9	-0.0	-1.7	-0.4	1.6	1.0	0.6
Irritability	0.4	0.7	1.1	-0.9	-1.1	0.5	0.2	1.0	0.9
Risk taking	0.9	1.3	4.1	0.1	-0.2	-2.0	0.3	-1.1	1.5
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.0	-0.6	0.4	-1.7	0.4	-0.7	1.7
Fractured/broken bones in last 5 years	2.4	3.1	5.2	0.9	2.2	-0.5	-2.3	-2.0	-1.8
Age started oral contraceptive pill	1.0	1.3	3.2	-1.6	1.8	0.4	-0.5	-0.8	-0.9
Diastolic blood pressure, automated reading	0.8	2.6	9.8	-0.4	-0.7	3.1	0.4	1.9	-1.0
Ever depressed for a whole week	2.9	3.6	8.8	-1.7	-1.2	1.1	2.1	1.6	3.0
Unable to work because of sickness or disability	0.2	0.2	0.4	-0.3	-0.5	0.5	0.6	0.5	-0.1
Commuting to job workplace: Cycle	1.8	2.1	3.5	1.3	1.7	-0.9	-1.1	-1.9	-1.6
Myopia	0.1	0.2	0.7	-0.1	0.3	0.3	0.2	-0.4	-0.9
Vascular/heart problems diagnosed by doctor	1.2	3.4	9.8	1.9	3.1	-0.1	-1.6	-1.6	-1.3
Cholesterol lowering medication	1.0	1.5	3.5	-0.5	-1.2	-1.8	0.7	-0.0	1.9
Medication: Omeprazole (e.g. Zanprol)	3.0	3.6	6.8	-2.1	-1.7	-1.8	-2.6	-2.1	0.2
Pain experienced in last month	1.0	1.6	5.8	-0.5	0.7	2.4	-0.2	1.7	-0.0
Supplements: Calcium	0.7	0.8	3.6	0.6	1.0	0.0	1.9	0.1	-0.3
Basal cell carcinoma (self-reported)	0.3	0.4	1.2	-0.3	0.5	-1.1	-0.5	-0.6	-0.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	4.3	-0.5	-2.1	-0.7	1.7	0.7	1.3
Deep venous thrombosis (DVT) (self-reported)	1.9	2.5	6.4	-0.5	0.0	-1.5	-2.4	-2.5	-0.7
Heart disease (siblings)	3.2	3.9	12.6	-3.0	-3.6	0.1	0.4	-0.2	1.3
Alcohol drinker status: Previous	0.3	0.3	0.7	-0.4	0.8	-0.1	0.8	0.6	0.3
Pack years of smoking	0.7	1.0	2.0	-1.3	0.3	1.0	0.9	0.5	1.4
Impedance of whole body	0.9	4.5	16.6	0.9	1.6	0.3	-4.1	-1.6	-2.1
Leg fat mass (left)	0.8	3.0	5.1	-0.9	-2.1	1.4	0.9	2.2	2.3
Arm predicted mass (left)	0.3	1.3	2.3	-0.7	-0.3	-1.5	-1.3	-1.1	1.4